{ "uniprot_canonical_ac": "Q9VD23-1", "uniprot_ac": "Q9VD23", "uniprot_id": "Q9VD23_DROME", "mass": { "chemical_mass": 83997.0, "monoisotopic_mass": 83997.0 }, "refseq": { "ac": "NP_651030", "name": "uncharacterized protein", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651030" }, "gene_names": [ { "name": "Dmel\\CG7069", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q9VD23", "id": "Q9VD23" }, { "name": "CG7069", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651030", "id": "NP_651030" }, { "name": "CG7069", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9VD23", "id": "Q9VD23" }, { "name": "Dmel\\CG7069", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651030", "id": "NP_651030" }, { "name": "Dmel_CG7069", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9VD23", "id": "Q9VD23" } ], "protein_names": [ { "name": "Pyruvate kinase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q9VD23" }, { "name": "2.7.1.40", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9VD23" }, { "name": "CG7069-PA", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651030", "id": "NP_651030" }, { "name": "uncharacterized protein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651030", "id": "NP_651030" } ], "function": [], "disease": [ { "disease_id": "DOID:0111077", "recommended_name": { "id": "DOID:0111077", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111077", "name": "pyruvate kinase deficiency of red cells", "description": "A congenital nonspherocytic hemolytic anemia that has_material_basis_in homozygous or compound heterozygous mutation in the PKLR gene on chromosome 1q22." }, "synonyms": [ { "id": "DOID:0111077", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111077", "name": "hemolytic anemia due to red cell pyruvate kinase deficiency", "description": "" }, { "id": "DOID:0111077", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111077", "name": "PK deficiency", "description": "" }, { "id": "DOID:0111077", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111077", "name": "pyruvate kinase deficiency of erythrocyte", "description": "" }, { "id": "MONDO:0009950", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009950", "name": "pyruvate kinase deficiency of red cells", "description": "Hemolytic anemia due to red cell pyruvate kinase (PK) deficiency is a metabolic disorder characterized by a variable degree of chronic nonspherocytic hemolytic anemia." }, { "id": "MONDO:0009950", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009950", "name": "PK deficiency", "description": "" }, { "id": "MONDO:0009950", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009950", "name": "hemolytic Anaemia due to pyruvate Kinase deficiency", "description": "" }, { "id": "MONDO:0009950", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009950", "name": "hemolytic Anemia due to pyruvate Kinase deficiency", "description": "" }, { "id": "MONDO:0009950", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009950", "name": "hemolytic anaemia due to red cell pyruvate kinase deficiency", "description": "" }, { "id": "MONDO:0009950", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009950", "name": "hemolytic anemia due to red cell pyruvate kinase deficiency", "description": "" }, { "id": "MONDO:0009950", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009950", "name": "pyruvate kinase deficiency of erythrocyte", "description": "" }, { "id": "MONDO:0009950", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009950", "name": "pyruvate kinase deficiency of erythrocytes", "description": "" }, { "id": "MONDO:0009950", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009950", "name": "pyruvate kinase deficiency of red cells", "description": "" }, { "id": "MONDO:0009950", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009950", "name": "Pk deficiency", "description": "" }, { "id": "MONDO:0009950", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009950", "name": "pyruvate kinase deficiency", "description": "" }, { "id": "MIM:266200", "resource": "MIM", "url": "https://www.omim.org/entry/266200", "name": "Pyruvate kinase deficiency of red cells", "description": "Pyruvate kinase deficiency of red cells" } ], "evidence": [ { "id": "0111077", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0111077" } ] }, { "disease_id": "DOID:12365", "recommended_name": { "id": "DOID:12365", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:12365", "name": "malaria", "description": "A parasitic protozoa infectious disease characterized as a vector-borne infectious disease caused by the presence of protozoan parasites of the genus Plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle." }, "synonyms": [ { "id": "DOID:12365", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:12365", "name": "induced malaria", "description": "" } ], "evidence": [ { "id": "12365", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:12365" } ] }, { "disease_id": "DOID:1926", "recommended_name": { "id": "DOID:1926", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1926", "name": "Gaucher's disease", "description": "A sphingolipidosis characterized by deficiency of the enzyme glucocerebrosidase which results in the accumulation of harmful quantities of the glycolipid glucocerebroside throughout the body, especially within the bone marrow, spleen and liver." }, "synonyms": [ { "id": "DOID:1926", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1926", "name": "Gaucher disease", "description": "" }, { "id": "DOID:1926", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1926", "name": "acid beta-glucosidase deficiency", "description": "" }, { "id": "DOID:1926", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1926", "name": "glocucerebrosidase deficiency", "description": "" }, { "id": "DOID:1926", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1926", "name": "glucosylceramide beta-glucosidase deficiency", "description": "" }, { "id": "DOID:1926", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1926", "name": "kerasin thesaurismosis", "description": "" } ], "evidence": [ { "id": "1926", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1926" } ] }, { "disease_id": "DOID:2861", "recommended_name": { "id": "DOID:2861", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2861", "name": "congenital nonspherocytic hemolytic anemia", "description": "" }, "synonyms": [ { "id": "DOID:2861", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2861", "name": "HNSHA", "description": "" }, { "id": "DOID:2861", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2861", "name": "congenital nonspherocytic hemolytic anaemia", "description": "" }, { "id": "DOID:2861", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2861", "name": "hereditary nonspherocytic hemolytic anaemia", "description": "" }, { "id": "DOID:2861", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2861", "name": "hereditary nonspherocytic hemolytic anemia", "description": "" }, { "id": "MONDO:0010480", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010480", "name": "anemia, nonspherocytic hemolytic, due to G6PD deficiency", "description": "An X-linked genetic condition caused by alterations in the gene G6PD that result in severely decreased activity levels of the enzyme glucose-6-phosphate dehydrogenase. Individuals with hemizygous G6PD variants associated with CNSHA have CNSHA. Individuals with G6PD variants that cause CNSHA are at risk for acute hemolytic anemia in response to certain medication exposures, chemical exposures, infections, or consumption of fava beans." }, { "id": "MONDO:0010480", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010480", "name": "Class I G6PD deficiency", "description": "" }, { "id": "MONDO:0010480", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010480", "name": "anemia, nonspherocytic hemolytic, due to G6PD deficiency", "description": "" }, { "id": "MONDO:0010480", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010480", "name": "class I glucose-6-phosphate dehydrogenase deficiency", "description": "" }, { "id": "MONDO:0010480", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010480", "name": "hemolytic anaemia due to G6PD deficiency", "description": "" }, { "id": "MONDO:0010480", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010480", "name": "hemolytic anemia due to G6PD deficiency", "description": "" }, { "id": "MONDO:0010480", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010480", "name": "hemolytic anemia, G6PD deficient (favism), X-linked dominant", "description": "" }, { "id": "MONDO:0010480", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010480", "name": "severe hemolytic anaemia due to G6PD deficiency", "description": "" }, { "id": "MONDO:0010480", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010480", "name": "severe hemolytic anemia due to G6PD deficiency", "description": "" }, { "id": "MONDO:0008790", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008790", "name": "anemia, nonspherocytic hemolytic, possibly due to defect in porphyrin metabolism", "description": "" }, { "id": "MONDO:0008790", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008790", "name": "anemia, nonspherocytic hemolytic, possibly due to defect in porphyrin metabolism", "description": "" }, { "id": "MONDO:0008789", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008789", "name": "anemia, nonspherocytic hemolytic, associated with abnormality of red cell membrane", "description": "" }, { "id": "MONDO:0008789", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008789", "name": "anemia, nonspherocytic hemolytic, associated with abnormality of red cell membrane", "description": "" }, { "id": "MONDO:0013275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013275", "name": "hemolytic anemia due to glucophosphate isomerase deficiency", "description": "Glucosephosphate isomerase (GPI) deficiency is an erythroenzymopathy characterized by chronic nonspherocytic hemolytic anemia." }, { "id": "MONDO:0013275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013275", "name": "glucosephosphate isomerase deficiency", "description": "" }, { "id": "MONDO:0013275", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013275", "name": "hemolytic anemia, nonspherocytic, due to glucose phosphate isomerase deficiency", "description": "" }, { "id": "MIM:300908", "resource": "MIM", "url": "https://www.omim.org/entry/300908", "name": "Anemia, non-spherocytic hemolytic, due to G6PD deficiency", "description": "Anemia, non-spherocytic hemolytic, due to G6PD deficiency" }, { "id": "MIM:613470", "resource": "MIM", "url": "https://www.omim.org/entry/613470", "name": "Hemolytic anemia, non-spherocytic, due to glucose phosphate isomerase deficiency", "description": "Hemolytic anemia, non-spherocytic, due to glucose phosphate isomerase deficiency" } ], "evidence": [ { "id": "2861", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:2861" } ] }, { "disease_id": "DOID:9352", "recommended_name": { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "type 2 diabetes mellitus", "description": "A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin." }, "synonyms": [ { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "NIDDM", "description": "" }, { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "non-insulin-dependent diabetes mellitus", "description": "" }, { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "type 2 diabetes", "description": "" }, { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "type II diabetes mellitus", "description": "" }, { "id": "DOID:9352", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9352", "name": "insulin resistance", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "diabetes mellitus, noninsulin-dependent, 4", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "diabetes mellitus, noninsulin-dependent, 4", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "diabetes mellitus, noninsulin-dependent, type 4", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "Niddm4", "description": "" }, { "id": "MONDO:0011955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011955", "name": "noninsulin-dependent diabetes mellitus 4", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type 2 diabetes mellitus", "description": "A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity." }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "NIDDM", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "T2DM - type 2 diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "adult onset diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "adult-onset diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitis type 2", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitis type II", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent, association with", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent, late onset", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type 2", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type II", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes, type 2", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "insulin resistance, severe, digenic", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "non-insulin dependent diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "non-insulin dependent diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "non-insulin-dependent diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "noninsulin dependent diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "noninsulin-dependent diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type 2 diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type 2 diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type 2 diabetes mellitus non-insulin dependent", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type II diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type II diabetes mellitus", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent, 2", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, non-insulin-dependent, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, noninsulin-dependent, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type 2, protection against", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type 2, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "diabetes mellitus, type II, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "hypertension, insulin resistance-related, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "insulin resistance, susceptibility to", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "maturity-onset diabetes", "description": "" }, { "id": "MONDO:0005148", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005148", "name": "type 2 diabetes mellitus, susceptibility to", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "diabetes mellitus, noninsulin-dependent, 1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "diabetes mellitus, noninsulin-dependent 1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "diabetes mellitus, noninsulin-dependent, 1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "diabetes mellitus, noninsulin-dependent, type 1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "NIDDM1", "description": "" }, { "id": "MONDO:0011027", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011027", "name": "noninsulin-dependent diabetes mellitus 1", "description": "" }, { "id": "MONDO:0011072", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011072", "name": "diabetes mellitus, noninsulin-dependent, 2", "description": "" }, { "id": "MONDO:0011072", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011072", "name": "NIDDM2", "description": "" }, { "id": "MONDO:0011072", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011072", "name": "diabetes mellitus, noninsulin-dependent, 2", "description": "" }, { "id": "MONDO:0011072", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011072", "name": "noninsulin-dependent diabetes mellitus 2", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "diabetes mellitus, noninsulin-dependent, 3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "diabetes mellitus, noninsulin-dependent, 3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "diabetes mellitus, noninsulin-dependent, type 3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "type 2 diabetes mellitus 3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "NIDDM3", "description": "" }, { "id": "MONDO:0011363", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011363", "name": "noninsulin-dependent diabetes mellitus 3", "description": "" }, { "id": "MIM:125853", "resource": "MIM", "url": "https://www.omim.org/entry/125853", "name": "Type 2 diabetes mellitus", "description": "Type 2 diabetes mellitus" }, { "id": "MIM:601283", "resource": "MIM", "url": "https://www.omim.org/entry/601283", "name": "Type 2 diabetes mellitus 1", "description": "Type 2 diabetes mellitus 1" } ], "evidence": [ { "id": "9352", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9352" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9VD23", "url": "https://www.uniprot.org/uniprot/Q9VD23" } ], "common_name": "Fruit fly" } ], "gene": [ { "name": "Dmel\\CG7069", "url": "https://www.uniprot.org/uniprot/Q9VD23", "locus": { "chromosome": "3R", "start_pos": 22375579, "end_pos": 22372835, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "FBgn0038952", "url": "https://www.ensembl.org/id/FBgn0038952" } ] } } ], "crossref": [ { "id": "FBgn0038952", "url": "https://bgee.org/?page=gene&gene_id=FBgn0038952", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "FBgn0038952", "url": "https://flybase.org/reports/FBgn0038952", "database": "FlyBase", "categories": [ "Organism-specific" ] }, { "id": "42621", "url": "https://www.ncbi.nlm.nih.gov/gene/42621", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q9VD23", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q9VD23*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001697", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001697", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011037", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011037", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015793", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015793", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015795", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015795", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015806", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015806", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015813", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015813", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018209", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018209", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036918", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036918", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040442", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040442", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dme:Dmel_CG7069", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG7069", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FRLFTIR", "url": "https://omabrowser.org/oma/group/FRLFTIR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "312683at2759", "url": "http://www.orthodb.org/?query=312683at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11817", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11817", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11817:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11817:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00224", "url": "http://pfam.xfam.org/family/PF00224", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF02887", "url": "http://pfam.xfam.org/family/PF02887", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "R-DME-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-6798695", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DME-70171", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-70171", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_651030", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651030", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "18157", "url": "https://www.rhea-db.org/rhea/18157", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q9VD23", "url": "https://www.uniprot.org/uniprot/Q9VD23", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9VD23-1", "url": "https://www.uniprot.org/uniprot/Q9VD23-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRVVRMNFSHGSHEYHCQTIQAARKAIAMYVEQTGLPRTLAIALDTKGPEIRTGKLAGGNDRAEIELKTGDKVTLSTKKEMADKSNKDNIYVDYQRLPQLVKPGNRVFVDDGLIALIVKESKGDEVICQVENGGKLGSHKGINLPGVPVDLPSVTEKDKQDLKFGAEQKVDMIFASFIRDANALKEIRQVLGPAGACIKIISKIENHQGLVNIDDIIRESDGIMVARGDMGIEIPTEDVPLAQKSIVAKCNKVGKPVICATQMMESMTNKPRPTRAEASDVANAIFDGCDAVMLSGETAKGKYPVECVQCMARICAKVEAVLWYESLQNSLKREIRTSAADHISAVTTAIAEAATVGQARAIVVASPCSMVAQMVSHMRPPCPIVMLTGNESEAAQSLLFRGIYPLLVEEMVIGSFNFRRIMQSGLKLMGKMDILEPGQKGSVVLVNAMSAEKITFRLFTIRQQTKEERDQDERCRKLALEQSCKERAEKEECRKLQQAEECQKQKLAKKCKQFEEKQKVCPKKNDTPKNDCPKKDCPKKECPKQDDEISKCRQMQEAEAEERKCKEEFEQMCKLAEEKRKEAEKCRKADEERRKEEAEKCRKLEEDRKCKLAEEKKRNEEELKIIEAEVAKLEAAEKAKRLKEEEKKKEELMKCKQRNEAKKKREEAERCKRKERERELAEMENKWKQVAEKRKRKKAAEMCRKIEDAKEKAAAESADKILKAVCEKLKQSLSDPDKSKKGKK", "length": 744, "header": "tr|Q9VD23-1|Q9VD23_DROME Isoform 1 of Pyruvate kinase OS=Drosophila melanogaster OX=7227 GN=Dmel\\CG7069 PE=3 SV=2 CANONICAL=Q9VD23-1" }, "isoforms": [ { "isoform_ac": "Q9VD23-1", "url": "", "sequence": { "sequence": "MRVVRMNFSHGSHEYHCQTIQAARKAIAMYVEQTGLPRTLAIALDTKGPEIRTGKLAGGNDRAEIELKTGDKVTLSTKKEMADKSNKDNIYVDYQRLPQLVKPGNRVFVDDGLIALIVKESKGDEVICQVENGGKLGSHKGINLPGVPVDLPSVTEKDKQDLKFGAEQKVDMIFASFIRDANALKEIRQVLGPAGACIKIISKIENHQGLVNIDDIIRESDGIMVARGDMGIEIPTEDVPLAQKSIVAKCNKVGKPVICATQMMESMTNKPRPTRAEASDVANAIFDGCDAVMLSGETAKGKYPVECVQCMARICAKVEAVLWYESLQNSLKREIRTSAADHISAVTTAIAEAATVGQARAIVVASPCSMVAQMVSHMRPPCPIVMLTGNESEAAQSLLFRGIYPLLVEEMVIGSFNFRRIMQSGLKLMGKMDILEPGQKGSVVLVNAMSAEKITFRLFTIRQQTKEERDQDERCRKLALEQSCKERAEKEECRKLQQAEECQKQKLAKKCKQFEEKQKVCPKKNDTPKNDCPKKDCPKKECPKQDDEISKCRQMQEAEAEERKCKEEFEQMCKLAEEKRKEAEKCRKADEERRKEEAEKCRKLEEDRKCKLAEEKKRNEEELKIIEAEVAKLEAAEKAKRLKEEEKKKEELMKCKQRNEAKKKREEAERCKRKERERELAEMENKWKQVAEKRKRKKAAEMCRKIEDAKEKAAAESADKILKAVCEKLKQSLSDPDKSKKGKK", "length": 744, "header": "tr|Q9VD23-1|Q9VD23_DROME Isoform 1 of Pyruvate kinase OS=Drosophila melanogaster OX=7227 GN=Dmel\\CG7069 PE=3 SV=2 CANONICAL=Q9VD23-1" }, "locus": { "chromosome": "3R", "start_pos": 22375468, "end_pos": 22373237, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0084215", "url": "https://www.ensembl.org/id/FBtr0084215" }, { "database": "Ensembl Peptide", "id": "FBpp0083612", "url": "https://www.ensembl.org/id/FBpp0083612" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "The genome sequence of Drosophila melanogaster.", "journal": "Science", "date": "2000", "authors": "Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA, Galle RF, George RA, Lewis SE, Richards S, Ashburner M, Henderson SN, Sutton GG, Wortman JR, Yandell MD, Zhang Q, Chen LX, Brandon RC, Rogers YH, Blazej RG, Champe M, Pfeiffer BD, Wan KH, Doyle C, Baxter EG, Helt G, Nelson CR, Gabor GL, Abril JF, Agbayani A, An HJ, Andrews-Pfannkoch C, Baldwin D, Ballew RM, Basu A, Baxendale J, Bayraktaroglu L, Beasley EM, Beeson KY, Benos PV, Berman BP, Bhandari D, Bolshakov S, Borkova D, Botchan MR, Bouck J, Brokstein P, Brottier P, Burtis KC, Busam DA, Butler H, Cadieu E, Center A, Chandra I, Cherry JM, Cawley S, Dahlke C, Davenport LB, Davies P, de Pablos B, Delcher A, Deng Z, Mays AD, Dew I, Dietz SM, Dodson K, Doup LE, Downes M, Dugan-Rocha S, Dunkov BC, Dunn P, Durbin KJ, Evangelista CC, Ferraz C, Ferriera S, Fleischmann W, Fosler C, Gabrielian AE, Garg NS, Gelbart WM, Glasser K, Glodek A, Gong F, Gorrell JH, Gu Z, Guan P, Harris M, Harris NL, Harvey D, Heiman TJ, Hernandez JR, Houck J, Hostin D, Houston KA, Howland TJ, Wei MH, Ibegwam C, Jalali M, Kalush F, Karpen GH, Ke Z, Kennison JA, Ketchum KA, Kimmel BE, Kodira CD, Kraft C, Kravitz S, Kulp D, Lai Z, Lasko P, Lei Y, Levitsky AA, Li J, Li Z, Liang Y, Lin X, Liu X, Mattei B, McIntosh TC, McLeod MP, McPherson D, Merkulov G, Milshina NV, Mobarry C, Morris J, Moshrefi A, Mount SM, Moy M, Murphy B, Murphy L, Muzny DM, Nelson DL, Nelson DR, Nelson KA, Nixon K, Nusskern DR, Pacleb JM, Palazzolo M, Pittman GS, Pan S, Pollard J, Puri V, Reese MG, Reinert K, Remington K, Saunders RD, Scheeler F, Shen H, Shue BC, Siden-Kiamos I, Simpson M, Skupski MP, Smith T, Spier E, Spradling AC, Stapleton M, Strong R, Sun E, Svirskas R, Tector C, Turner R, Venter E, Wang AH, Wang X, Wang ZY, Wassarman DA, Weinstock GM, Weissenbach J, Williams SM, WoodageT, Worley KC, Wu D, Yang S, Yao QA, Ye J, Yeh RF, Zaveri JS, Zhan M, Zhang G, Zhao Q, Zheng L, Zheng XH, Zhong FN, Zhong W, Zhou X, Zhu S, Zhu X, Smith HO, Gibbs RA, Myers EW, Rubin GM, Venter JC", "evidence": [ { "database": "UniProtKB", "id": "Q9VD23", "url": "https://www.uniprot.org/uniprot/Q9VD23" } ], "reference": [ { "type": "PubMed", "id": "10731132", "url": "https://glygen.org/publication/PubMed/10731132" } ] }, { "title": "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence.", "journal": "Genome Biol.", "date": "2002", "authors": "Celniker SE, Wheeler DA, Kronmiller B, Carlson JW, Halpern A, Patel S, Adams M, Champe M, Dugan SP, Frise E, Hodgson A, George RA, Hoskins RA, Laverty T, Muzny DM, Nelson CR, Pacleb JM, Park S, Pfeiffer BD, Richards S, Sodergren EJ, Svirskas R, Tabor PE, Wan K, Stapleton M, Sutton GG, Venter C, Weinstock G, Scherer SE, Myers EW, Gibbs RA, Rubin GM", "evidence": [ { "database": "UniProtKB", "id": "Q9VD23", "url": "https://www.uniprot.org/uniprot/Q9VD23" } ], "reference": [ { "type": "PubMed", "id": "12537568", "url": "https://glygen.org/publication/PubMed/12537568" } ] }, { "title": "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.", "journal": "Genome Biol.", "date": "2002", "authors": "Misra S, Crosby MA, Mungall CJ, Matthews BB, Campbell KS, Hradecky P, Huang Y, Kaminker JS, Millburn GH, Prochnik SE, Smith CD, Tupy JL, Whitfied EJ, Bayraktaroglu L, Berman BP, Bettencourt BR, Celniker SE, de Grey AD, Drysdale RA, Harris NL, Richter J, Russo S, Schroeder AJ, Shu SQ, Stapleton M, Yamada C, Ashburner M, Gelbart WM, Rubin GM, Lewis SE", "evidence": [ { "database": "UniProtKB", "id": "Q9VD23", "url": "https://www.uniprot.org/uniprot/Q9VD23" } ], "reference": [ { "type": "PubMed", "id": "12537572", "url": "https://glygen.org/publication/PubMed/12537572" } ] }, { "title": "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective.", "journal": "Genome Biol.", "date": "2002", "authors": "Kaminker JS, Bergman CM, Kronmiller B, Carlson J, Svirskas R, Patel S, Frise E, Wheeler DA, Lewis SE, Rubin GM, Ashburner M, Celniker SE", "evidence": [ { "database": "UniProtKB", "id": "Q9VD23", "url": "https://www.uniprot.org/uniprot/Q9VD23" } ], "reference": [ { "type": "PubMed", "id": "12537573", "url": "https://glygen.org/publication/PubMed/12537573" } ] }, { "title": "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.", "journal": "Genome Biol.", "date": "2002", "authors": "Hoskins RA, Smith CD, Carlson JW, Carvalho AB, Halpern A, Kaminker JS, Kennedy C, Mungall CJ, Sullivan BA, Sutton GG, Yasuhara JC, Wakimoto BT, Myers EW, Celniker SE, Rubin GM, Karpen GH", "evidence": [ { "database": "UniProtKB", "id": "Q9VD23", "url": "https://www.uniprot.org/uniprot/Q9VD23" } ], "reference": [ { "type": "PubMed", "id": "12537574", "url": "https://glygen.org/publication/PubMed/12537574" } ] }, { "title": "Combined evidence annotation of transposable elements in genome sequences.", "journal": "PLoS Comput. Biol.", "date": "2005", "authors": "Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D", "evidence": [ { "database": "UniProtKB", "id": "Q9VD23", "url": "https://www.uniprot.org/uniprot/Q9VD23" } ], "reference": [ { "type": "PubMed", "id": "16110336", "url": "https://glygen.org/publication/PubMed/16110336" } ] }, { "title": "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.", "journal": "Science", "date": "2007", "authors": "Smith CD, Shu S, Mungall CJ, Karpen GH", "evidence": [ { "database": "UniProtKB", "id": "Q9VD23", "url": "https://www.uniprot.org/uniprot/Q9VD23" } ], "reference": [ { "type": "PubMed", "id": "17569856", "url": "https://glygen.org/publication/PubMed/17569856" } ] }, { "title": "Sequence finishing and mapping of Drosophila melanogaster heterochromatin.", "journal": "Science", "date": "2007", "authors": "Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE", "evidence": [ { "database": "UniProtKB", "id": "Q9VD23", "url": "https://www.uniprot.org/uniprot/Q9VD23" } ], "reference": [ { "type": "PubMed", "id": "17569867", "url": "https://glygen.org/publication/PubMed/17569867" } ] } ], "pathway": [ { "id": "dme:Dmel_CG7069", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG7069", "resource": "KEGG Pathway" }, { "id": "R-DME-6798695", "name": "Neutrophil degranulation", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" }, { "id": "R-DME-70171", "name": "Glycolysis", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-70171", "resource": "Reactome", "description": "Glycolysis" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "Q9VD23", "url": "https://www.uniprot.org/uniprot/Q9VD23" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q9VD23", "url": "https://www.uniprot.org/uniprot/Q9VD23" } ], "pmid": "" }, { "name": "kinase activity", "id": "GO:0016301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016301", "evidence": [ { "database": "UniProtKB", "id": "Q9VD23", "url": "https://www.uniprot.org/uniprot/Q9VD23" } ], "pmid": "" }, { "name": "potassium ion binding", "id": "GO:0030955", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030955", "evidence": [ { "database": "UniProtKB", "id": "Q9VD23", "url": "https://www.uniprot.org/uniprot/Q9VD23" } ], "pmid": "" }, { "name": "pyruvate kinase activity", "id": "GO:0004743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004743", "evidence": [ { "database": "UniProtKB", "id": "Q9VD23", "url": "https://www.uniprot.org/uniprot/Q9VD23" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q9VD23", "url": "https://www.uniprot.org/uniprot/Q9VD23" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q9VD23", "url": "https://www.uniprot.org/uniprot/Q9VD23" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "pyruvate metabolic process", "id": "GO:0006090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006090", "evidence": [ { "database": "UniProtKB", "id": "Q9VD23", "url": "https://www.uniprot.org/uniprot/Q9VD23" } ], "pmid": "" }, { "name": "phosphorylation", "id": "GO:0016310", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016310", "evidence": [ { "database": "UniProtKB", "id": "Q9VD23", "url": "https://www.uniprot.org/uniprot/Q9VD23" } ], "pmid": "" }, { "name": "glycolytic process", "id": "GO:0006096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006096", "evidence": [ { "database": "UniProtKB", "id": "Q9VD23", "url": "https://www.uniprot.org/uniprot/Q9VD23" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 390, "end_pos": 392, "annotation": "n_glycosylation_sequon" }, { "start_pos": 525, "end_pos": 527, "annotation": "n_glycosylation_sequon" }, { "start_pos": 7, "end_pos": 9, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "18157", "name": "", "equation": "ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P11980-1", "P12928-1", "M0RD14-1", "A0A8I6AKN1-1", "A0A8I6A0Y9-1", "A0A8I6A7K2-1", "P14618-1", "P30613-1", "P53657-1", "P52480-1", "P00549-1", "P52489-1", "Q54RF5-1", "O62619-1", "Q9VD23-1", "Q9VQH0-1" ], "evidence": [ { "id": "18157", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/18157" } ] }, { "id": "R-DME-6798748", "name": "Exocytosis of secretory granule lumen proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, secretory granule lumen", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q7K209-1", "Q7KMQ0-1", "Q7KUC2-1", "Q9V3V6-1", "Q9W1K6-1", "P13060-1", "Q9NFT9-1", "Q9V3H2-1", "Q9VZZ4-1", "A0A0B4LFW5-1", "X2JF73-1", "P00528-1", "P08879-1", "P52034-1", "Q7KN62-1", "Q9V3G3-1", "M9PE19-1", "Q9VFG4-1", "Q8IMS5-1", "Q9VBF5-1", "Q9VLR2-1", "Q9VXE3-1", "Q9VQH0-1", "P07764-1", "P12426-1", "P17336-1", "P52029-1", "Q23976-1", "Q95029-1", "Q9NFT7-1", "Q9VHP0-1", "A1Z7P1-1", "B7Z0E0-1", "Q9I7M8-1", "Q9W2H8-1", "X2JEY5-1", "Q9VAN7-1", "Q9VD23-1", "Q9VNK6-1", "Q9VTV9-1", "O61443-1", "O62619-1", "Q07152-1", "Q7JYW9-1", "Q9W330-1" ], "evidence": [ { "id": "R-DME-6798748", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-6798748" } ] }, { "id": "R-DME-6800434", "name": "Exocytosis of ficolin-rich granule lumen proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, ficolin-1-rich granule lumen", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P40417-3", "Q7K209-1", "Q7KMQ0-1", "Q9V3V6-1", "Q9VQ13-1", "Q9W1K6-1", "Q9W5G3-1", "P13060-1", "Q9NFT9-1", "Q9V3H2-1", "A0A0B4LFW5-1", "X2JF73-1", "P08879-1", "P52034-1", "Q7KN62-1", "Q9V3G3-1", "M9PE19-1", "Q9VFG4-1", "A1ZBG9-1", "Q8IMS5-1", "Q9VBF5-1", "Q9VLK3-1", "Q9VLR2-1", "Q9VQ11-1", "Q9VY87-1", "Q9W122-1", "Q9VQH0-1", "P07764-1", "P17336-1", "P52029-1", "Q23976-1", "Q8MPP3-1", "Q95029-1", "Q9NFT7-1", "Q9VHP0-1", "Q9VP22-1", "A1Z7P1-1", "B7Z0E0-1", "Q9W2H8-1", "X2JEY5-1", "Q9VAN7-1", "Q9VD23-1", "Q9VNK6-1", "Q7K485-1", "Q86PD7-1", "Q9VTV9-1", "Q9VJ39-1", "O61443-1", "O62619-1", "Q07152-1", "Q95RX5-1", "Q9VUY9-1", "Q7JYW9-1", "Q7KN85-1", "Q9VGE7-1", "Q9VGN8-1", "Q9VYH1-1", "Q9W330-1" ], "evidence": [ { "id": "R-DME-6800434", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-6800434" } ] }, { "id": "R-DME-71670", "name": "phosphoenolpyruvate + ADP => pyruvate + ATP", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [ "R-ALL-29492" ], "output_participant_list": [], "enzyme_list": [ "Q9VFG4-1", "Q9VQH0-1", "Q9VD23-1", "O62619-1" ], "evidence": [ { "id": "R-DME-71670", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-71670" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-29492", "participant_name": "PEP [cytosol]", "crossref": [ { "id": "58702", "database": "ChEBI", "url": "" }, { "id": "3674425", "database": "PubChem Compound", "url": "" }, { "id": "PHOSPHO-ENOL-PYRUVATE", "database": "AraCyc", "url": "" }, { "id": "C00074", "database": "KEGG Gene", "url": "" }, { "id": "73-89-2", "database": "CAS", "url": "" }, { "id": "000003870145", "database": "ZINC", "url": "" }, { "id": "138-08-9", "database": "CAS", "url": "" }, { "id": "c00074", "database": "KEGG Gene", "url": "" }, { "id": "58702", "database": "ChEBI", "url": "" }, { "id": "3674425", "database": "PubChem Compound", "url": "" }, { "id": "PHOSPHO-ENOL-PYRUVATE", "database": "AraCyc", "url": "" }, { "id": "C00074", "database": "KEGG Gene", "url": "" }, { "id": "73-89-2", "database": "CAS", "url": "" }, { "id": "000003870145", "database": "ZINC", "url": "" }, { "id": "138-08-9", "database": "CAS", "url": "" }, { "id": "c00074", "database": "KEGG Gene", "url": "" }, { "id": "58702", "database": "ChEBI", "url": "" }, { "id": "3674425", "database": "PubChem Compound", "url": "" }, { "id": "PHOSPHO-ENOL-PYRUVATE", "database": "AraCyc", "url": "" }, { "id": "C00074", "database": "KEGG Gene", "url": "" }, { "id": "73-89-2", "database": "CAS", "url": "" }, { "id": "000003870145", "database": "ZINC", "url": "" }, { "id": "138-08-9", "database": "CAS", "url": "" }, { "id": "c00074", "database": "KEGG Gene", "url": "" }, { "id": "58702", "database": "ChEBI", "url": "" }, { "id": "3674425", "database": "PubChem Compound", "url": "" }, { "id": "PHOSPHO-ENOL-PYRUVATE", "database": "AraCyc", "url": "" }, { "id": "C00074", "database": "KEGG Gene", "url": "" }, { "id": "73-89-2", "database": "CAS", "url": "" }, { "id": "000003870145", "database": "ZINC", "url": "" }, { "id": "138-08-9", "database": "CAS", "url": "" }, { "id": "c00074", "database": "KEGG Gene", "url": "" }, { "id": "58702", "database": "ChEBI", "url": "" }, { "id": "3674425", "database": "PubChem Compound", "url": "" }, { "id": "PHOSPHO-ENOL-PYRUVATE", "database": "AraCyc", "url": "" }, { "id": "C00074", "database": "KEGG Gene", "url": "" }, { "id": "73-89-2", "database": "CAS", "url": "" }, { "id": "000003870145", "database": "ZINC", "url": "" }, { "id": "138-08-9", "database": "CAS", "url": "" }, { "id": "c00074", "database": "KEGG Gene", "url": "" }, { "id": "c00074", "database": "KEGG Gene", "url": "" }, { "id": "C00074", "database": "KEGG Gene", "url": "" }, { "id": "3674425", "database": "PubChem Compound", "url": "" }, { "id": "000003870145", "database": "ZINC", "url": "" }, { "id": "58702", "database": "ChEBI", "url": "" }, { "id": "PHOSPHO-ENOL-PYRUVATE", "database": "AraCyc", "url": "" }, { "id": "138-08-9", "database": "CAS", "url": "" }, { "id": "73-89-2", "database": "CAS", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A0B4LFW5", "gene_name": "Gyg", "activity": [ { "ec_number": "2.4.1.186", "activity": "[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + H(+) + UDP.", "evidence": [ { "id": "A0A0B4LFW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0B4LFW5" } ] } ] }, { "uniprot_ac": "A0A8I6A0Y9", "gene_name": "ENSRNOG00000064082", "activity": [ { "ec_number": "2.7.1.40", "activity": "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate.", "evidence": [ { "id": "A0A8I6A0Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A0Y9" } ] }, { "ec_number": "2.7.1.40", "activity": "", "evidence": [ { "id": "A0A8I6A0Y9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A0Y9" } ] } ] }, { "uniprot_ac": "A0A8I6A7K2", "gene_name": "ENSRNOG00000068788", "activity": [ { "ec_number": "2.7.1.40", "activity": "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate.", "evidence": [ { "id": "A0A8I6A7K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A7K2" } ] }, { "ec_number": "2.7.1.40", "activity": "", "evidence": [ { "id": "A0A8I6A7K2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A7K2" } ] } ] }, { "uniprot_ac": "A0A8I6AKN1", "gene_name": "ENSRNOG00000065303", "activity": [ { "ec_number": "2.7.1.40", "activity": "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate.", "evidence": [ { "id": "A0A8I6AKN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AKN1" } ] }, { "ec_number": "2.7.1.40", "activity": "", "evidence": [ { "id": "A0A8I6AKN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AKN1" } ] } ] }, { "uniprot_ac": "A1Z7P1", "gene_name": "Pgm2a", "activity": [ { "ec_number": "5.4.2.2", "activity": "alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.", "evidence": [ { "id": "A1Z7P1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1Z7P1" } ] }, { "ec_number": "5.4.2.2", "activity": "", "evidence": [ { "id": "A1Z7P1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1Z7P1" } ] } ] }, { "uniprot_ac": "A1ZBG9", "gene_name": "Dmel\\CG15117", "activity": [ { "ec_number": "3.2.1.31", "activity": "a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate.", "evidence": [ { "id": "A1ZBG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1ZBG9" } ] }, { "ec_number": "3.2.1.31", "activity": "", "evidence": [ { "id": "A1ZBG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1ZBG9" } ] } ] }, { "uniprot_ac": "B7Z0E0", "gene_name": "Idh", "activity": [ { "ec_number": "1.1.1.42", "activity": "D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH.", "evidence": [ { "id": "B7Z0E0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B7Z0E0" } ] }, { "ec_number": "1.1.1.42", "activity": "", "evidence": [ { "id": "B7Z0E0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B7Z0E0" } ] } ] }, { "uniprot_ac": "M0RD14", "gene_name": "LOC100362738", "activity": [ { "ec_number": "2.7.1.40", "activity": "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate.", "evidence": [ { "id": "M0RD14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RD14" } ] }, { "ec_number": "2.7.1.40", "activity": "", "evidence": [ { "id": "M0RD14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RD14" } ] } ] }, { "uniprot_ac": "M9PE19", "gene_name": "CG16760", "activity": [ { "ec_number": "2.4.2.1", "activity": "a purine 2'-deoxy-D-ribonucleoside + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + a purine nucleobase.", "evidence": [ { "id": "M9PE19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M9PE19" } ] }, { "ec_number": "2.4.2.1", "activity": "", "evidence": [ { "id": "M9PE19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M9PE19" } ] } ] }, { "uniprot_ac": "O61443", "gene_name": "p38b", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O61443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O61443" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "O61443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O61443" } ] } ] }, { "uniprot_ac": "O62619", "gene_name": "PyK", "activity": [ { "ec_number": "2.7.1.40", "activity": "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate.", "evidence": [ { "id": "O62619", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O62619" } ] }, { "ec_number": "2.7.1.40", "activity": "", "evidence": [ { "id": "O62619", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O62619" } ] } ] }, { "uniprot_ac": "P00528", "gene_name": "Src64B", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P00528", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00528" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P00528", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00528" } ] } ] }, { "uniprot_ac": "P00549", "gene_name": "CDC19", "activity": [ { "ec_number": "2.7.1.40", "activity": "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate.", "evidence": [ { "id": "P00549", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00549" } ] }, { "ec_number": "2.7.1.40", "activity": "", "evidence": [ { "id": "P00549", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00549" } ] } ] }, { "uniprot_ac": "P07764", "gene_name": "Ald1", "activity": [ { "ec_number": "4.1.2.13", "activity": "beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate.", "evidence": [ { "id": "P07764", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07764" } ] }, { "ec_number": "4.1.2.13", "activity": "", "evidence": [ { "id": "P07764", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07764" } ] } ] }, { "uniprot_ac": "P08879", "gene_name": "awd", "activity": [ { "ec_number": "2.7.4.6", "activity": "a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP.", "evidence": [ { "id": "P08879", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08879" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P08879", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08879" } ] } ] }, { "uniprot_ac": "P11980", "gene_name": "Pkm", "activity": [ { "ec_number": "2.7.1.40", "activity": "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate.", "evidence": [ { "id": "P11980", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11980" } ] }, { "ec_number": "2.7.1.40", "activity": "", "evidence": [ { "id": "P11980", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11980" } ] }, { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P11980", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11980" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P11980", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11980" } ] } ] }, { "uniprot_ac": "P12426", "gene_name": "Aprt", "activity": [ { "ec_number": "2.4.2.7", "activity": "AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine.", "evidence": [ { "id": "P12426", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12426" } ] }, { "ec_number": "2.4.2.7", "activity": "", "evidence": [ { "id": "P12426", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12426" } ] } ] }, { "uniprot_ac": "P12928", "gene_name": "Pklr", "activity": [ { "ec_number": "2.7.1.40", "activity": "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate.", "evidence": [ { "id": "P12928", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12928" } ] }, { "ec_number": "2.7.1.40", "activity": "", "evidence": [ { "id": "P12928", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12928" } ] } ] }, { "uniprot_ac": "P13060", "gene_name": "eEF2", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P13060", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13060" } ] } ] }, { "uniprot_ac": "P14618", "gene_name": "PKM", "activity": [ { "ec_number": "2.7.1.40", "activity": "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate.", "evidence": [ { "id": "P14618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14618" } ] }, { "ec_number": "2.7.1.40", "activity": "", "evidence": [ { "id": "P14618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14618" } ] }, { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P14618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14618" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P14618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14618" } ] } ] }, { "uniprot_ac": "P17336", "gene_name": "Cat", "activity": [ { "ec_number": "1.11.1.6", "activity": "2 H2O2 = 2 H2O + O2.", "evidence": [ { "id": "P17336", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17336" } ] }, { "ec_number": "1.11.1.6", "activity": "", "evidence": [ { "id": "P17336", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17336" } ] } ] }, { "uniprot_ac": "P30613", "gene_name": "PKLR", "activity": [ { "ec_number": "2.7.1.40", "activity": "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate.", "evidence": [ { "id": "P30613", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30613" } ] }, { "ec_number": "2.7.1.40", "activity": "", "evidence": [ { "id": "P30613", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30613" } ] } ] }, { "uniprot_ac": "P40417", "gene_name": "rl", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P40417", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40417" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P40417", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40417" } ] } ] }, { "uniprot_ac": "P52029", "gene_name": "Pgi", "activity": [ { "ec_number": "5.3.1.9", "activity": "alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate.", "evidence": [ { "id": "P52029", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52029" } ] }, { "ec_number": "5.3.1.9", "activity": "", "evidence": [ { "id": "P52029", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52029" } ] } ] }, { "uniprot_ac": "P52034", "gene_name": "Pfk", "activity": [ { "ec_number": "2.7.1.11", "activity": "ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+).", "evidence": [ { "id": "P52034", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52034" } ] }, { "ec_number": "2.7.1.11", "activity": "", "evidence": [ { "id": "P52034", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52034" } ] } ] }, { "uniprot_ac": "P52480", "gene_name": "Pkm", "activity": [ { "ec_number": "2.7.1.40", "activity": "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate.", "evidence": [ { "id": "P52480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52480" } ] }, { "ec_number": "2.7.1.40", "activity": "", "evidence": [ { "id": "P52480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52480" } ] }, { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P52480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52480" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P52480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52480" } ] } ] }, { "uniprot_ac": "P52489", "gene_name": "PYK2", "activity": [ { "ec_number": "2.7.1.40", "activity": "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate.", "evidence": [ { "id": "P52489", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52489" } ] }, { "ec_number": "2.7.1.40", "activity": "", "evidence": [ { "id": "P52489", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52489" } ] } ] }, { "uniprot_ac": "P53657", "gene_name": "Pklr", "activity": [ { "ec_number": "2.7.1.40", "activity": "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate.", "evidence": [ { "id": "P53657", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53657" } ] }, { "ec_number": "2.7.1.40", "activity": "", "evidence": [ { "id": "P53657", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53657" } ] } ] }, { "uniprot_ac": "Q07152", "gene_name": "ras", "activity": [ { "ec_number": "1.1.1.205", "activity": "H2O + IMP + NAD(+) = H(+) + NADH + XMP.", "evidence": [ { "id": "Q07152", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07152" } ] }, { "ec_number": "1.1.1.205", "activity": "", "evidence": [ { "id": "Q07152", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07152" } ] } ] }, { "uniprot_ac": "Q23976", "gene_name": "Irbp", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q23976", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q23976" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q23976", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q23976" } ] } ] }, { "uniprot_ac": "Q54RF5", "gene_name": "pyk", "activity": [ { "ec_number": "2.7.1.40", "activity": "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate.", "evidence": [ { "id": "Q54RF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54RF5" } ] }, { "ec_number": "2.7.1.40", "activity": "", "evidence": [ { "id": "Q54RF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54RF5" } ] } ] }, { "uniprot_ac": "Q7JYW9", "gene_name": "Hex-C", "activity": [ { "ec_number": "2.7.1.-", "activity": "", "evidence": [ { "id": "Q7JYW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7JYW9" } ] } ] }, { "uniprot_ac": "Q7K209", "gene_name": "Dera", "activity": [ { "ec_number": "4.1.2.4", "activity": "2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate.", "evidence": [ { "id": "Q7K209", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7K209" } ] }, { "ec_number": "4.1.2.4", "activity": "", "evidence": [ { "id": "Q7K209", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7K209" } ] } ] }, { "uniprot_ac": "Q7K485", "gene_name": "cathD", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q7K485", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7K485" } ] } ] }, { "uniprot_ac": "Q7KMQ0", "gene_name": "Rpt1", "activity": [ { "ec_number": "3.6.1.3", "activity": "", "evidence": [ { "id": "Q7KMQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7KMQ0" } ] } ] }, { "uniprot_ac": "Q7KN62", "gene_name": "TER94", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q7KN62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7KN62" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "Q7KN62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7KN62" } ] } ] }, { "uniprot_ac": "Q7KN85", "gene_name": "ATPCL", "activity": [ { "ec_number": "2.3.3.8", "activity": "acetyl-CoA + ADP + oxaloacetate + phosphate = ATP + citrate + CoA.", "evidence": [ { "id": "Q7KN85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7KN85" } ] }, { "ec_number": "2.3.3.8", "activity": "", "evidence": [ { "id": "Q7KN85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7KN85" } ] } ] }, { "uniprot_ac": "Q7KUC2", "gene_name": "Pdxk", "activity": [ { "ec_number": "2.7.1.35", "activity": "ATP + pyridoxal = ADP + H(+) + pyridoxal 5'-phosphate.", "evidence": [ { "id": "Q7KUC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7KUC2" } ] }, { "ec_number": "2.7.1.35", "activity": "", "evidence": [ { "id": "Q7KUC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7KUC2" } ] } ] }, { "uniprot_ac": "Q86PD7", "gene_name": "isoQC", "activity": [ { "ec_number": "2.3.2.5", "activity": "N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+).", "evidence": [ { "id": "Q86PD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86PD7" } ] }, { "ec_number": "2.3.2.5", "activity": "", "evidence": [ { "id": "Q86PD7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86PD7" } ] } ] }, { "uniprot_ac": "Q8IMS5", "gene_name": "BcDNA:AT31683", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q8IMS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IMS5" } ] } ] }, { "uniprot_ac": "Q8MPP3", "gene_name": "Mmp2", "activity": [ { "ec_number": "3.4.24.-", "activity": "", "evidence": [ { "id": "Q8MPP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8MPP3" } ] } ] }, { "uniprot_ac": "Q95029", "gene_name": "Cp1", "activity": [ { "ec_number": "3.4.22.15", "activity": "Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.", "evidence": [ { "id": "Q95029", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q95029" } ] }, { "ec_number": "3.4.22.15", "activity": "", "evidence": [ { "id": "Q95029", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q95029" } ] }, { "ec_number": "3.4.-.-", "activity": "", "evidence": [ { "id": "Q95029", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q95029" } ] }, { "ec_number": "3.4.22.-", "activity": "", "evidence": [ { "id": "Q95029", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q95029" } ] } ] }, { "uniprot_ac": "Q95RX5", "gene_name": "Kcmf1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q95RX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q95RX5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q95RX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q95RX5" } ] } ] }, { "uniprot_ac": "Q9I7M8", "gene_name": "Ku80", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q9I7M8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9I7M8" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q9I7M8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9I7M8" } ] } ] }, { "uniprot_ac": "Q9NFT7", "gene_name": "Hex-t2", "activity": [ { "ec_number": "2.7.1.1", "activity": "ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+).", "evidence": [ { "id": "Q9NFT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NFT7" } ] }, { "ec_number": "2.7.1.1", "activity": "", "evidence": [ { "id": "Q9NFT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NFT7" } ] } ] }, { "uniprot_ac": "Q9NFT9", "gene_name": "Hex-t1", "activity": [ { "ec_number": "2.7.1.1", "activity": "ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+).", "evidence": [ { "id": "Q9NFT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NFT9" } ] }, { "ec_number": "2.7.1.1", "activity": "", "evidence": [ { "id": "Q9NFT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NFT9" } ] } ] }, { "uniprot_ac": "Q9V3G3", "gene_name": "cyp33", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q9V3G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9V3G3" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q9V3G3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9V3G3" } ] } ] }, { "uniprot_ac": "Q9V3H2", "gene_name": "Rpn11", "activity": [ { "ec_number": "3.4.19.-", "activity": "", "evidence": [ { "id": "Q9V3H2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9V3H2" } ] } ] }, { "uniprot_ac": "Q9V3V6", "gene_name": "Rpt5", "activity": [ { "ec_number": "3.-.-.-", "activity": "", "evidence": [ { "id": "Q9V3V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9V3V6" } ] }, { "ec_number": "3.6.1.3", "activity": "", "evidence": [ { "id": "Q9V3V6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9V3V6" } ] } ] }, { "uniprot_ac": "Q9VAN7", "gene_name": "Pglym78", "activity": [ { "ec_number": "5.4.2.11", "activity": "(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate.", "evidence": [ { "id": "Q9VAN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VAN7" } ] }, { "ec_number": "5.4.2.4", "activity": "(2R)-3-phospho-glyceroyl phosphate = (2R)-2,3-bisphosphoglycerate + H(+).", "evidence": [ { "id": "Q9VAN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VAN7" } ] }, { "ec_number": "5.4.2.11", "activity": "", "evidence": [ { "id": "Q9VAN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VAN7" } ] }, { "ec_number": "5.4.2.4", "activity": "", "evidence": [ { "id": "Q9VAN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VAN7" } ] } ] }, { "uniprot_ac": "Q9VBF5", "gene_name": "Ald2", "activity": [ { "ec_number": "4.1.2.13", "activity": "beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate.", "evidence": [ { "id": "Q9VBF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VBF5" } ] }, { "ec_number": "4.1.2.13", "activity": "", "evidence": [ { "id": "Q9VBF5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VBF5" } ] } ] }, { "uniprot_ac": "Q9VD23", "gene_name": "Dmel\\CG7069", "activity": [ { "ec_number": "2.7.1.40", "activity": "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate.", "evidence": [ { "id": "Q9VD23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VD23" } ] }, { "ec_number": "2.7.1.40", "activity": "", "evidence": [ { "id": "Q9VD23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VD23" } ] } ] }, { "uniprot_ac": "Q9VFG4", "gene_name": "Dmel\\CG7362", "activity": [ { "ec_number": "2.7.1.40", "activity": "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate.", "evidence": [ { "id": "Q9VFG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VFG4" } ] }, { "ec_number": "2.7.1.40", "activity": "", "evidence": [ { "id": "Q9VFG4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VFG4" } ] } ] }, { "uniprot_ac": "Q9VGE7", "gene_name": "Ect3", "activity": [ { "ec_number": "3.2.1.23", "activity": "Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.", "evidence": [ { "id": "Q9VGE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VGE7" } ] }, { "ec_number": "3.2.1.23", "activity": "", "evidence": [ { "id": "Q9VGE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VGE7" } ] } ] }, { "uniprot_ac": "Q9VGN8", "gene_name": "Dmel\\CG5276", "activity": [ { "ec_number": "3.6.1.15", "activity": "a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + H(+) + phosphate.", "evidence": [ { "id": "Q9VGN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VGN8" } ] }, { "ec_number": "3.6.1.6", "activity": "ADP + H2O = AMP + H(+) + phosphate.", "evidence": [ { "id": "Q9VGN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VGN8" } ] }, { "ec_number": "3.6.1.42", "activity": "GDP + H2O = GMP + H(+) + phosphate.", "evidence": [ { "id": "Q9VGN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VGN8" } ] } ] }, { "uniprot_ac": "Q9VHP0", "gene_name": "bel", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q9VHP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VHP0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q9VHP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VHP0" } ] } ] }, { "uniprot_ac": "Q9VJ39", "gene_name": "pepCG10602", "activity": [ { "ec_number": "3.3.2.6", "activity": "H2O + leukotriene A4 = leukotriene B4.", "evidence": [ { "id": "Q9VJ39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VJ39" } ] }, { "ec_number": "3.3.2.6", "activity": "", "evidence": [ { "id": "Q9VJ39", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VJ39" } ] } ] }, { "uniprot_ac": "Q9VLK3", "gene_name": "Bace", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q9VLK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VLK3" } ] } ] }, { "uniprot_ac": "Q9VLR2", "gene_name": "Dmel\\CG8353", "activity": [ { "ec_number": "3.5.4.5", "activity": "2'-deoxycytidine + H(+) + H2O = 2'-deoxyuridine + NH4(+).", "evidence": [ { "id": "Q9VLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VLR2" } ] }, { "ec_number": "3.5.4.5", "activity": "", "evidence": [ { "id": "Q9VLR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VLR2" } ] } ] }, { "uniprot_ac": "Q9VNK6", "gene_name": "Dmel\\CG11459", "activity": [ { "ec_number": "3.4.22.-", "activity": "", "evidence": [ { "id": "Q9VNK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VNK6" } ] } ] }, { "uniprot_ac": "Q9VP22", "gene_name": "Cdk12", "activity": [ { "ec_number": "2.7.11.22", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9VP22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VP22" } ] }, { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].", "evidence": [ { "id": "Q9VP22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VP22" } ] }, { "ec_number": "2.7.11.22", "activity": "", "evidence": [ { "id": "Q9VP22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VP22" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q9VP22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VP22" } ] } ] }, { "uniprot_ac": "Q9VQ11", "gene_name": "Dmel\\CG31928", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q9VQ11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VQ11" } ] } ] }, { "uniprot_ac": "Q9VQ13", "gene_name": "Dmel\\CG31926", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q9VQ13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VQ13" } ] } ] }, { "uniprot_ac": "Q9VQH0", "gene_name": "Dmel\\CG2964", "activity": [ { "ec_number": "2.7.1.40", "activity": "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate.", "evidence": [ { "id": "Q9VQH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VQH0" } ] }, { "ec_number": "2.7.1.40", "activity": "", "evidence": [ { "id": "Q9VQH0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VQH0" } ] } ] }, { "uniprot_ac": "Q9VTV9", "gene_name": "Pbgs", "activity": [ { "ec_number": "4.2.1.24", "activity": "2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen.", "evidence": [ { "id": "Q9VTV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VTV9" } ] }, { "ec_number": "4.2.1.24", "activity": "", "evidence": [ { "id": "Q9VTV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VTV9" } ] } ] }, { "uniprot_ac": "Q9VUY9", "gene_name": "Pgm1", "activity": [ { "ec_number": "5.4.2.2", "activity": "alpha-D-glucose 1-phosphate = alpha-D-glucose 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