{ "uniprot_canonical_ac": "Q9V4C8-1", "uniprot_ac": "Q9V4C8", "uniprot_id": "HCF_DROME", "mass": { "chemical_mass": 160185.0, "monoisotopic_mass": 160185.0 }, "refseq": { "ac": "NP_001245420", "name": "host cell factor, isoform E", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245420" }, "gene_names": [ { "name": "Hcf", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q9V4C8", "id": "Q9V4C8" }, { "name": "CG1710", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9V4C8", "id": "Q9V4C8" }, { "name": "Hcf", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245420", "id": "NP_001245420" }, { "name": "anon-WO0172774.48; CG1710; dHcf; dHCF; dHcf1; Dmel\\CG1710; HCF; Hcf1; HCF1; HCF_DROME", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245420", "id": "NP_001245420" } ], "protein_names": [ { "name": "Host cell factor", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q9V4C8" }, { "name": "CG1710-PE; Hcf-PE; host cell factor; heat cell factor; FBgn0039904; host cell factor 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245420", "id": "NP_001245420" }, { "name": "dHcf", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9V4C8" }, { "name": "host cell factor, isoform E", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245420", "id": "NP_001245420" } ], "function": [ { "annotation": "May be involved in control of the cell cycle.", "evidence": [ { "database": "UniProtKB", "id": "Q9V4C8", "url": "https://www.uniprot.org/uniprot/Q9V4C8#function" }, { "database": "PubMed", "id": "12494450", "url": "https://glygen.org/publication/PubMed/12494450" } ] } ], "disease": [ { "disease_id": "DOID:0111814", "recommended_name": { "id": "DOID:0111814", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111814", "name": "methylmalonic acidemia and homocysteinemia cblX type", "description": "A methylmalonic acidemia characterized by onset in infancy of severely delayed psychomotor development, failure to thrive, intellectual disability, and intractable epilepsy that has_material_basis_in hemizygous or homozygous mutation in the HCFC1 gene on chromosome Xq28." }, "synonyms": [ { "id": "DOID:0111814", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111814", "name": "mental retardation, X-linked 3", "description": "" }, { "id": "DOID:0111814", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111814", "name": "combined defect in adenosylcobalamin and methylcobalamin synthesis, type cblX", "description": "" }, { "id": "DOID:0111814", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111814", "name": "methylmalonic aciduria with homocystinuria, type cblX", "description": "" }, { "id": "MONDO:0010657", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010657", "name": "methylmalonic acidemia with homocystinuria, type cblX", "description": "" }, { "id": "MONDO:0010657", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010657", "name": "combined defect in adenosylcobalamin and methylcobalamin synthesis, type cblX", "description": "" }, { "id": "MONDO:0010657", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010657", "name": "methylmalonic aciduria and homocysteinemia, cblx type, X-linked recessive", "description": "" }, { "id": "MONDO:0010657", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010657", "name": "methylmalonic aciduria with homocystinuria, type cblX", "description": "" }, { "id": "MONDO:0010657", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010657", "name": "intellectual disability, X-linked 3", "description": "" }, { "id": "MONDO:0010657", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010657", "name": "mental retardation, X-linked 3", "description": "" }, { "id": "MONDO:0010657", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010657", "name": "methylmalonic acidemia and HOMOCYSTEINEMIA, cblX type", "description": "" }, { "id": "MONDO:0010657", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010657", "name": "methylmalonic acidemia and homocysteinemia type cblX", "description": "" }, { "id": "MIM:309541", "resource": "MIM", "url": "https://www.omim.org/entry/309541", "name": "Methylmalonic aciduria and homocystinuria, cblX type", "description": "Methylmalonic aciduria and homocystinuria, cblX type" } ], "evidence": [ { "id": "0111814", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0111814" } ] }, { "disease_id": "DOID:1682", "recommended_name": { "id": "DOID:1682", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1682", "name": "congenital heart disease", "description": "" }, "synonyms": [ { "id": "DOID:1682", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1682", "name": "Congenital Heart Defects", "description": "" }, { "id": "DOID:1682", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1682", "name": "Congenital anomaly of heart", "description": "" }, { "id": "DOID:1682", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1682", "name": "Heart Malformation", "description": "" }, { "id": "DOID:1682", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1682", "name": "congenital heart defect", "description": "" }, { "id": "DOID:1682", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1682", "name": "heart defect", "description": "" } ], "evidence": [ { "id": "1682", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1682" } ] } ], "snv": [], "mutagenesis": [ { "start_pos": 1470, "end_pos": 1471, "sequence_org": "KR", "sequence_mut": "", "comment": "Causes accumulation exclusively in the cytoplasm.", "evidence": [ { "database": "UniProtKB", "id": "Q9V4C8", "url": "https://www.uniprot.org/uniprot/Q9V4C8" }, { "database": "PubMed", "id": "12609738", "url": "https://glygen.org/publication/PubMed/12609738" } ] }, { "start_pos": 1492, "end_pos": 1495, "sequence_org": "KRGR", "sequence_mut": "", "comment": "Causes accumulation exclusively in the cytoplasm.", "evidence": [ { "database": "UniProtKB", "id": "Q9V4C8", "url": "https://www.uniprot.org/uniprot/Q9V4C8" }, { "database": "PubMed", "id": "12609738", "url": "https://glygen.org/publication/PubMed/12609738" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9V4C8", "url": "https://www.uniprot.org/uniprot/Q9V4C8" } ], "common_name": "Fruit fly" } ], "gene": [ { "name": "Hcf", "url": "https://www.uniprot.org/uniprot/Q9V4C8", "locus": { "chromosome": "4", "start_pos": 375554, "end_pos": 359938, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "FBgn0039904", "url": "https://www.ensembl.org/id/FBgn0039904" } ] } } ], "crossref": [ { "id": "FBgn0039904", "url": "https://bgee.org/?page=gene&gene_id=FBgn0039904", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00063", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00063", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "FBgn0039904", "url": "https://flybase.org/reports/FBgn0039904", "database": "FlyBase", "categories": [ "Organism-specific" ] }, { "id": "43788", "url": "https://www.ncbi.nlm.nih.gov/gene/43788", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q9V4C8", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q9V4C8*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015915", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015915", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043536", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043536", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dme:Dmel_CG1710", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG1710", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q9V4C8", "url": "https://oglcnac.org/atlas/detail/Q9V4C8", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "Q9V4C8", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9V4C8", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "GPCGTIH", "url": "https://omabrowser.org/oma/group/GPCGTIH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5477547at2759", "url": "http://www.orthodb.org/?query=5477547at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46003", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46003", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46003:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46003:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF13415", "url": "http://pfam.xfam.org/family/PF13415", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13854", "url": "http://pfam.xfam.org/family/PF13854", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q9V4C8", "url": "http://purl.obolibrary.org/obo/PR_Q9V4C8", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-DME-5689603", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-5689603", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DME-9772755", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-9772755", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001245420", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245420", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q9V4C8", "url": "https://www.uniprot.org/uniprot/Q9V4C8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9V4C8-1", "url": "https://www.uniprot.org/uniprot/Q9V4C8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9V4C8-5", "url": "https://www.uniprot.org/uniprot/Q9V4C8-5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9V4C8-6", "url": "https://www.uniprot.org/uniprot/Q9V4C8-6", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEGSDFVDPAFSSGERISASDLNSEHIIQAENHSFANRISMDMDVPDGHQLDSNLTGFRWKRVLNPTGPQPRPRHGHRAINIKELMVVFGGGNEGIVDELHVYNTVTNQWYVPVLKGDVPNGCAAYGFVVEGTRMFVFGGMIEYGKYSNELYELQATKWEWRKMYPESPDSGLSPCPRLGHSFTMVGEKIFLFGGLANESDDPKNNIPKYLNDLYILDTRGVHSHNGKWIVPKTYGDSPPPRESHTGISFATKSNGNLNLLIYGGMSGCRLGDLWLLETDSMTWSKPKTSGEAPLPRSLHSSTMIGNKMYVFGGWVPLVINDSKSTTEREWKCTNTLAVLDLETMTWENVTLDTVEENVPRARAGHCAVGIQSRLYVWSGRDGYRKAWNNQVCCKDLWYLEVSKPLYAVKVALVRASTHALELSWTATTFAAAYVLQIQKIEQPLNTSSKLLSNNIVQQGTPTSAETSGINISANRSGSALGLGVEATSTVLKLEKESLQLSGCQPETNVQPSVNDLLQSMSQPSSPASRADKDPLSSGGGTTFNLSTSVASVHPQISVISSTAAVTGNDTASPSGAINSILQKFRPVVTAVRTSTTTAVSIATSTSDPLSVRVPSTMSANVVLSSSSSTLRIVPSVTASHSLRIASSQASGNNCRSSSAINILKTALPNVAVQSQPTSSTTTSIGGKQYFIQKPLTLAPNVQLQFVKTSGGMTVQTLPKVNFTASKGTPPHGISIANPHLASGITQIQGSTVPGSQIQKPIVSGNVLKLVSPHTMAGGKLIMKNSNILQMGKVTPNVMGGKPAFVITNKQGTPLGNQQIIIVTTGGNVRSVPTSTVMTSAGGSASGTNIVSIVNSTSTTPSPLQALSGQKTLISNQSGVKMLRNISSVQASSSMAFGQKQSGTPIHQKTALYIGGKAVTVMSTNTSMAASGNKVMVLPGTSSNNSPATTTALSARKSFVFNAGGSPRTVTLATKSINAKSIPQSQPVTETNNHSVATIKDTDPMDDIIEQLDGAGDLLKLSESEGQHGSEENENNGENATSSSASALFTGGDTAGPSRAQNPIVMEHPVDIIEDVSGVSSTTDVNETAIVSGDTIESLKMSEKENDDVKSMGEKSILSDDCHQPTTSETEAATILTTIKSAEALVLETAEIRKDHTGCTIGSLKENQDENKKFKQRQESSPSQNIHQFQNVDGSQLEALASAALLQAATSDTTALALKELIERPESETNTRSSNIAEIQQNNVQSTLAVVVPNTSQNENQKWHTVGVFKDLSHTVTSYIDSNCISDSFFDGIDVDNLPDFSKFPRTNLEPGTAYRFRLSAINSCGRGEWGEISSFKTCLPGFPGAPSAIKISKDVKEGAHLTWEPPPAQKTKEIIEYSVYLAVKPTAKDKALSTPQLAFVRVYVGAANQCTVPNASLSNAHVDCSNKPAIIFRIAARNQKGYGPATQVRWLQDPAAAKQHTPTVTPNLKRGPEKSTIGSSNIANTFCSPHKRGRNGLHD", "length": 1500, "header": "sp|Q9V4C8-1|HCF_DROME Isoform 1 of Host cell factor OS=Drosophila melanogaster OX=7227 GN=Hcf PE=1 SV=2 CANONICAL=Q9V4C8-1" }, "isoforms": [ { "isoform_ac": "Q9V4C8-1", "url": "", "sequence": { "sequence": "MEGSDFVDPAFSSGERISASDLNSEHIIQAENHSFANRISMDMDVPDGHQLDSNLTGFRWKRVLNPTGPQPRPRHGHRAINIKELMVVFGGGNEGIVDELHVYNTVTNQWYVPVLKGDVPNGCAAYGFVVEGTRMFVFGGMIEYGKYSNELYELQATKWEWRKMYPESPDSGLSPCPRLGHSFTMVGEKIFLFGGLANESDDPKNNIPKYLNDLYILDTRGVHSHNGKWIVPKTYGDSPPPRESHTGISFATKSNGNLNLLIYGGMSGCRLGDLWLLETDSMTWSKPKTSGEAPLPRSLHSSTMIGNKMYVFGGWVPLVINDSKSTTEREWKCTNTLAVLDLETMTWENVTLDTVEENVPRARAGHCAVGIQSRLYVWSGRDGYRKAWNNQVCCKDLWYLEVSKPLYAVKVALVRASTHALELSWTATTFAAAYVLQIQKIEQPLNTSSKLLSNNIVQQGTPTSAETSGINISANRSGSALGLGVEATSTVLKLEKESLQLSGCQPETNVQPSVNDLLQSMSQPSSPASRADKDPLSSGGGTTFNLSTSVASVHPQISVISSTAAVTGNDTASPSGAINSILQKFRPVVTAVRTSTTTAVSIATSTSDPLSVRVPSTMSANVVLSSSSSTLRIVPSVTASHSLRIASSQASGNNCRSSSAINILKTALPNVAVQSQPTSSTTTSIGGKQYFIQKPLTLAPNVQLQFVKTSGGMTVQTLPKVNFTASKGTPPHGISIANPHLASGITQIQGSTVPGSQIQKPIVSGNVLKLVSPHTMAGGKLIMKNSNILQMGKVTPNVMGGKPAFVITNKQGTPLGNQQIIIVTTGGNVRSVPTSTVMTSAGGSASGTNIVSIVNSTSTTPSPLQALSGQKTLISNQSGVKMLRNISSVQASSSMAFGQKQSGTPIHQKTALYIGGKAVTVMSTNTSMAASGNKVMVLPGTSSNNSPATTTALSARKSFVFNAGGSPRTVTLATKSINAKSIPQSQPVTETNNHSVATIKDTDPMDDIIEQLDGAGDLLKLSESEGQHGSEENENNGENATSSSASALFTGGDTAGPSRAQNPIVMEHPVDIIEDVSGVSSTTDVNETAIVSGDTIESLKMSEKENDDVKSMGEKSILSDDCHQPTTSETEAATILTTIKSAEALVLETAEIRKDHTGCTIGSLKENQDENKKFKQRQESSPSQNIHQFQNVDGSQLEALASAALLQAATSDTTALALKELIERPESETNTRSSNIAEIQQNNVQSTLAVVVPNTSQNENQKWHTVGVFKDLSHTVTSYIDSNCISDSFFDGIDVDNLPDFSKFPRTNLEPGTAYRFRLSAINSCGRGEWGEISSFKTCLPGFPGAPSAIKISKDVKEGAHLTWEPPPAQKTKEIIEYSVYLAVKPTAKDKALSTPQLAFVRVYVGAANQCTVPNASLSNAHVDCSNKPAIIFRIAARNQKGYGPATQVRWLQDPAAAKQHTPTVTPNLKRGPEKSTIGSSNIANTFCSPHKRGRNGLHD", "length": 1500, "header": "sp|Q9V4C8-1|HCF_DROME Isoform 1 of Host cell factor OS=Drosophila melanogaster OX=7227 GN=Hcf PE=1 SV=2 CANONICAL=Q9V4C8-1" }, "locus": { "chromosome": "4", "start_pos": 372389, "end_pos": 360691, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0345284", "url": "https://www.ensembl.org/id/FBtr0345284" }, { "database": "Ensembl Peptide", "id": "FBpp0311451", "url": "https://www.ensembl.org/id/FBpp0311451" } ] } }, { "isoform_ac": "Q9V4C8-5", "url": "", "sequence": { "sequence": "MEGSDFVDPAFSSGERISASDLNSEHIIQAENHSFANRISMDMDVPDGHQLDSNLTGFRWKRVLNPTGPQPRPRHGHRAINIKELMVVFGGGNEGIVDELHVYNTVTNQWYVPVLKGDVPNGCAAYGFVVEGTRMFVFGGMIEYGKYSNELYELQATKWEWRKMYPESPDSGLSPCPRLGHSFTMVGEKIFLFGGLANESDDPKNNIPKYLNDLYILDTRGVHSHNGKWIVPKTYGDSPPPRESHTGISFATKSNGNLNLLIYGGMSGCRLGDLWLLETDSMTWSKPKTSGEAPLPRSLHSSTMIGNKMYVFGGWVPLVINDSKSTTEREWKCTNTLAVLDLETMTWENVTLDTVEENVPRARAGHCAVGIQSRLYVWSGRDGYRKAWNNQPLNTSSKLLSNNIVQQGTPTSAETSGINISANRSGSALGLGVEATSTVLKLEKESLQLSGCQPETNVQPSVNDLLQSMSQPSSPASRADKDPLSSGGGTTFNLSTSVASVHPQISVISSTAAVTGNDTASPSGAINSILQKFRPVVTAVRTSTTTAVSIATSTSDPLSVRVPSTMSANVVLSSSSSTLRIVPSVTASHSLRIASSQASGNNCRSSSAINILKTALPNVAVQSQPTSSTTTSIGGKQYFIQKPLTLAPNVQLQFVKTSGGMTVQTLPKVNFTASKGTPPHGISIANPHLASGITQIQGSTVPGSQIQKPIVSGNVLKLVSPHTMAGGKLIMKNSNILQMGKVTPNVMGGKPAFVITNKQGTPLGNQQIIIVTTGGNVRSVPTSTVMTSAGGSASGTNIVSIVNSTSTTPSPLQALSGQKTLISNQSGVKMLRNISSVQASSSMAFGQKQSGTPIHQKTALYIGGKAVTVMSTNTSMAASGNKVMVLPGTSSNNSPATTTALSARKSFVFNAGGSPRTVTLATKSINAKSIPQSQPVTETNNHSVATIKDTDPMDDIIEQLDGAGDLLKLSESEGQHGSEENENNGENATSSSASALFTGGDTAGPSRAQNPIVMEHPVDIIEDVSGVSSTTDVNETAIVSGDTIESLKMSEKENDDVKSMGEKSILSDDCHQPTTSETEAATILTTIKSAEALVLETAEIRKDHTGCTIGSLKENQDENKKFKQRQESSPSQNIHQFQNVDGSQLEALASAALLQAATSDTTALALKELIERPESETNTRSSNIAEIQQNNVQSTLAVVVPNTSQNENQKWHTVGVFKDLSHTVTSYIDSNCISDSFFDGIDVDNLPDFSKFPRTNLEPGTAYRFRLSAINSCGRGEWGEISSFKTCLPGFPGAPSAIKISKDVKEGAHLTWEPPPAQKTKEIIEYSVYLAVKPTAKDKALSTPQLAFVRVYVGAANQCTVPNASLSNAHVDCSNKPAIIFRIAARNQKGYGPATQVRWLQDPAAAKQHTPTVTPNLKRGPEKSTIGSSNIANTFCSPHKRGRNGLHD", "length": 1448, "header": "sp|Q9V4C8-5|HCF_DROME Isoform 5 of Host cell factor OS=Drosophila melanogaster OX=7227 GN=Hcf PE=1 SV=2 CANONICAL=Q9V4C8-1" }, "locus": { "chromosome": "4", "start_pos": 372389, "end_pos": 360691, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0334479", "url": "https://www.ensembl.org/id/FBtr0334479" }, { "database": "Ensembl Peptide", "id": "FBpp0306551", "url": "https://www.ensembl.org/id/FBpp0306551" } ] } }, { "isoform_ac": "Q9V4C8-6", "url": "", "sequence": { "sequence": "MEGSDFVDPAFSSGERISASDLNSEHIIQAENHSFANRISMDMDVPDGHQLDSNLTGFRWKRVLNPTGPQPRPRHGHRAINIKELMVVFGGGNEGIVDELHVYNTVTNQWYVPVLKGDVPNGCAAYGFVVEGTRMFVFGGMIEYGKYSNELYELQATKWEWRKMYPESPDSGLSPCPRLGHSFTMVGEKIFLFGGLANESDDPKNNIPKYLNDLYILDTRGVHSHNGKWIVPKTYGDSPPPRESHTGISFATKSNGNLNLLIYGGMSGCRLGDLWLLETDSMTWSKPKTSGEAPLPRSLHSSTMIGNKMYVFGGWVPLVINDSKSTTEREWKCTNTLAVLDLETMTWENVTLDTVEENVPRARAGHCAVGIQSRLYVWSGRDGYRKAWNNQVRVCCKDLWYLEVSKPLYAVKVALVRASTHALELSWTATTFAAAYVLQIQKIEQPLNTSSKLLSNNIVQQGTPTSAETSGINISANRSGSALGLGVEATSTVLKLEKESLQLSGCQPETNVQPSVNDLLQSMSQPSSPASRADKDPLSSGGGTTFNLSTSVASVHPQISVISSTAAVTGNDTASPSGAINSILQKFRPVVTAVRTSTTTAVSIATSTSDPLSVRVPSTMSANVVLSSSSSTLRIVPSVTASHSLRIASSQASGNNCRSSSAINILKTALPNVAVQSQPTSSTTTSIGGKQYFIQKPLTLAPNVQLQFVKTSGGMTVQTLPKVNFTASKGTPPHGISIANPHLASGITQIQGSTVPGSQIQKPIVSGNVLKLVSPHTMAGGKLIMKNSNILQMGKGTPLGNQQIIIVTTGGNVRSVPTSTVMTSAGGSASGTNIVSIVNSTSTTPSPLQALSGQKTLISNQSGVKMLRNISSVQASSSMAFGQKQSGTPIHQKTALYIGGKAVTVMSTNTSMAASGNKVMVLPGTSSNNSPATTTALSARKSFVFNAGGSPRTVTLATKSINAKSIPQSQPVTETNNHSVATIKDTDPMDDIIEQLDGAGDLLKLSESEGQHGSEENENNGENATSSSASALFTGGDTAGPSRAQNPIVMEHPVDIIEDVSGVSSTTDVNETAIVSGDTIESLKMSEKENDDVKSMGEKSILSDDCHQPTTSETEAATILTTIKSAEALVLETAEIRKDHTGCTIGSLKENQDENKKFKQRQESSPSQNIHQFQNVDGSQLEALASAALLQAATSDTTALALKELIERPESETNTRSSNIAEIQQNNVQSTLAVVVPNTSQNENQKWHTVGVFKDLSHTVTSYIDSNCISDSFFDGIDVDNLPDFSKFPRTNLEPGTAYRFRLSAINSCGRGEWGEISSFKTCLPGFPGAPSAIKISKDVKEGAHLTWEPPPAQKTKEIIEYSVYLAVKPTAKDKALSTPQLAFVRVYVGAANQCTVPNASLSNAHVDCSNKPAIIFRIAARNQKGYGPATQVRWLQDPAAAKQHTPTVTPNLKRGPEKSTIGSSNIANTFCSPHKRGRNGLHD", "length": 1484, "header": "sp|Q9V4C8-6|HCF_DROME Isoform 6 of Host cell factor OS=Drosophila melanogaster OX=7227 GN=Hcf PE=1 SV=2 CANONICAL=Q9V4C8-1" }, "locus": { "chromosome": "4", "start_pos": 372389, "end_pos": 360691, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0307379", "url": "https://www.ensembl.org/id/FBtr0307379" }, { "database": "Ensembl Peptide", "id": "FBpp0298368", "url": "https://www.ensembl.org/id/FBpp0298368" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 617, "start_aa": "Thr", "end_pos": 617, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr617", "evidence": [ { "id": "Q9V4C8", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q9V4C8" }, { "id": "26348912", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/26348912" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 839, "start_aa": "Thr", "end_pos": 839, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr839", "evidence": [ { "id": "Q9V4C8", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q9V4C8" }, { "id": "28604694", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28604694" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 840, "start_aa": "Ser", "end_pos": 840, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser840", "evidence": [ { "id": "Q9V4C8", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q9V4C8" }, { "id": "28604694", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28604694" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 844, "start_aa": "Ser", "end_pos": 844, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser844", "evidence": [ { "id": "Q9V4C8", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q9V4C8" }, { "id": "28604694", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28604694" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 846, "start_aa": "Ser", "end_pos": 846, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser846", "evidence": [ { "id": "Q9V4C8", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q9V4C8" }, { "id": "28604694", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28604694" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 848, "start_aa": "Thr", "end_pos": 848, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr848", "evidence": [ { "id": "Q9V4C8", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q9V4C8" }, { "id": "28604694", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28604694" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 852, "start_aa": "Ser", "end_pos": 852, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser852", "evidence": [ { "id": "Q9V4C8", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q9V4C8" }, { "id": "28604694", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28604694" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "Q9V4C8", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9V4C8" }, { "id": "27918560", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/27918560" }, { "id": "33925313", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33925313" }, { "id": "28604694", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28604694" } ] } ], "phosphorylation": [ { "start_pos": 1126, "end_pos": 1126, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q9V4C8", "url": "https://www.uniprot.org/uniprot/Q9V4C8" }, { "database": "PubMed", "id": "18327897", "url": "https://glygen.org/publication/PubMed/18327897" }, { "database": "phospho.ELM", "id": "Q9V4C8", "url": "http://phospho.elm.eu.org/byAccession/Q9V4C8.html" }, { "database": "iPTMnet", "id": "Q9V4C8", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9V4C8" } ], "site_lbl": "Thr1126" }, { "start_pos": 1489, "end_pos": 1489, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9V4C8", "url": "https://www.uniprot.org/uniprot/Q9V4C8" }, { "database": "PubMed", "id": "18327897", "url": "https://glygen.org/publication/PubMed/18327897" }, { "database": "phospho.ELM", "id": "Q9V4C8", "url": "http://phospho.elm.eu.org/byAccession/Q9V4C8.html" }, { "database": "iPTMnet", "id": "Q9V4C8", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9V4C8" } ], "site_lbl": "Ser1489" }, { "start_pos": 477, "end_pos": 477, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9V4C8", "url": "https://www.uniprot.org/uniprot/Q9V4C8" }, { "database": "PubMed", "id": "18327897", "url": "https://glygen.org/publication/PubMed/18327897" }, { "database": "phospho.ELM", "id": "Q9V4C8", "url": "http://phospho.elm.eu.org/byAccession/Q9V4C8.html" }, { "database": "iPTMnet", "id": "Q9V4C8", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9V4C8" } ], "site_lbl": "Ser477" }, { "start_pos": 958, "end_pos": 958, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9V4C8", "url": "https://www.uniprot.org/uniprot/Q9V4C8" }, { "database": "PubMed", "id": "18327897", "url": "https://glygen.org/publication/PubMed/18327897" }, { "database": "phospho.ELM", "id": "Q9V4C8", "url": "http://phospho.elm.eu.org/byAccession/Q9V4C8.html" }, { "database": "iPTMnet", "id": "Q9V4C8", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9V4C8" } ], "site_lbl": "Ser958" }, { "start_pos": 966, "end_pos": 966, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9V4C8", "url": "https://www.uniprot.org/uniprot/Q9V4C8" }, { "database": "PubMed", "id": "18327897", "url": "https://glygen.org/publication/PubMed/18327897" }, { "database": "phospho.ELM", "id": "Q9V4C8", "url": "http://phospho.elm.eu.org/byAccession/Q9V4C8.html" }, { "database": "iPTMnet", "id": "Q9V4C8", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9V4C8" } ], "site_lbl": "Ser966" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "The genome sequence of Drosophila melanogaster.", "journal": "Science", "date": "2000", "authors": "Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA, Galle RF, George RA, Lewis SE, Richards S, Ashburner M, Henderson SN, Sutton GG, Wortman JR, Yandell MD, Zhang Q, Chen LX, Brandon RC, Rogers YH, Blazej RG, Champe M, Pfeiffer BD, Wan KH, Doyle C, Baxter EG, Helt G, Nelson CR, Gabor GL, Abril JF, Agbayani A, An HJ, Andrews-Pfannkoch C, Baldwin D, Ballew RM, Basu A, Baxendale J, Bayraktaroglu L, Beasley EM, Beeson KY, Benos PV, Berman BP, Bhandari D, Bolshakov S, Borkova D, Botchan MR, Bouck J, Brokstein P, Brottier P, Burtis KC, Busam DA, Butler H, Cadieu E, Center A, Chandra I, Cherry JM, Cawley S, Dahlke C, Davenport LB, Davies P, de Pablos B, Delcher A, Deng Z, Mays AD, Dew I, Dietz SM, Dodson K, Doup LE, Downes M, Dugan-Rocha S, Dunkov BC, Dunn P, Durbin KJ, Evangelista CC, Ferraz C, Ferriera S, Fleischmann W, Fosler C, Gabrielian AE, Garg NS, Gelbart WM, Glasser K, Glodek A, Gong F, Gorrell JH, Gu Z, Guan P, Harris M, Harris NL, Harvey D, Heiman TJ, Hernandez JR, Houck J, Hostin D, Houston KA, Howland TJ, Wei MH, Ibegwam C, Jalali M, Kalush F, Karpen GH, Ke Z, Kennison JA, Ketchum KA, Kimmel BE, Kodira CD, Kraft C, Kravitz S, Kulp D, Lai Z, Lasko P, Lei Y, Levitsky AA, Li J, Li Z, Liang Y, Lin X, Liu X, Mattei B, McIntosh TC, McLeod MP, McPherson D, Merkulov G, Milshina NV, Mobarry C, Morris J, Moshrefi A, Mount SM, Moy M, Murphy B, Murphy L, Muzny DM, Nelson DL, Nelson DR, Nelson KA, Nixon K, Nusskern DR, Pacleb JM, Palazzolo M, Pittman GS, Pan S, Pollard J, Puri V, Reese MG, Reinert K, Remington K, Saunders RD, Scheeler F, Shen H, Shue BC, Siden-Kiamos I, Simpson M, Skupski MP, Smith T, Spier E, Spradling AC, Stapleton M, Strong R, Sun E, Svirskas R, Tector C, Turner R, Venter E, Wang AH, Wang X, Wang ZY, Wassarman DA, Weinstock GM, Weissenbach J, Williams SM, WoodageT, Worley KC, Wu D, Yang S, Yao QA, Ye J, Yeh RF, Zaveri JS, Zhan M, Zhang G, Zhao Q, Zheng L, Zheng XH, Zhong FN, Zhong W, Zhou X, Zhu S, Zhu X, Smith HO, Gibbs RA, Myers EW, Rubin GM, Venter JC", "evidence": [ { "database": "UniProtKB", "id": "Q9V4C8", "url": "https://www.uniprot.org/uniprot/Q9V4C8" } ], "reference": [ { "type": "PubMed", "id": "10731132", "url": "https://glygen.org/publication/PubMed/10731132" } ] }, { "title": "Molecular cloning of Drosophila HCF reveals proteolytic processing and self-association of the encoded protein.", "journal": "J. Cell. Physiol.", "date": "2003", "authors": "Mahajan SS, Johnson KM, Wilson AC", "evidence": [ { "database": "UniProtKB", "id": "Q9V4C8", "url": "https://www.uniprot.org/uniprot/Q9V4C8" } ], "reference": [ { "type": "PubMed", "id": "12494450", "url": "https://glygen.org/publication/PubMed/12494450" } ] }, { "title": "A Drosophila full-length cDNA resource.", "journal": "Genome Biol.", "date": "2002", "authors": "Stapleton M, Carlson J, Brokstein P, Yu C, Champe M, George R, Guarin H, Kronmiller B, Pacleb J, Park S, Wan K, Rubin GM, Celniker SE", "evidence": [ { "database": "UniProtKB", "id": "Q9V4C8", "url": "https://www.uniprot.org/uniprot/Q9V4C8" } ], "reference": [ { "type": "PubMed", "id": "12537569", "url": "https://glygen.org/publication/PubMed/12537569" } ] }, { "title": "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.", "journal": "Genome Biol.", "date": "2002", "authors": "Misra S, Crosby MA, Mungall CJ, Matthews BB, Campbell KS, Hradecky P, Huang Y, Kaminker JS, Millburn GH, Prochnik SE, Smith CD, Tupy JL, Whitfied EJ, Bayraktaroglu L, Berman BP, Bettencourt BR, Celniker SE, de Grey AD, Drysdale RA, Harris NL, Richter J, Russo S, Schroeder AJ, Shu SQ, Stapleton M, Yamada C, Ashburner M, Gelbart WM, Rubin GM, Lewis SE", "evidence": [ { "database": "UniProtKB", "id": "Q9V4C8", "url": "https://www.uniprot.org/uniprot/Q9V4C8" } ], "reference": [ { "type": "PubMed", "id": "12537572", "url": "https://glygen.org/publication/PubMed/12537572" } ] }, { "title": "Primary structure and compartmentalization of Drosophila melanogaster host cell factor.", "journal": "Gene", "date": "2003", "authors": "Izeta A, Malcomber S, O'Hare P", "evidence": [ { "database": "UniProtKB", "id": "Q9V4C8", "url": "https://www.uniprot.org/uniprot/Q9V4C8" } ], "reference": [ { "type": "PubMed", "id": "12609738", "url": "https://glygen.org/publication/PubMed/12609738" } ] }, { "title": "ATAC is a double histone acetyltransferase complex that stimulates nucleosome sliding.", "journal": "Nat. Struct. Mol. Biol.", "date": "2008", "authors": "Florens L., Gutierrez J.L., Swanson S.K., Washburn M.P., Workman J.L., Li B., Suganuma T., Abmayr S.M.", "evidence": [ { "database": "UniProtKB", "id": "Q9V4C8", "url": "https://www.uniprot.org/uniprot/Q9V4C8" } ], "reference": [ { "type": "PubMed", "id": "18327268", "url": "https://glygen.org/publication/PubMed/18327268" } ] }, { "title": "Phosphoproteome analysis of Drosophila melanogaster embryos.", "journal": "Journal of proteome research", "date": "2008", "authors": "Zhai B, Villen J, Beausoleil SA, Mintseris J, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "Q9V4C8", "url": "https://www.uniprot.org/uniprot/Q9V4C8" }, { "database": "iPTMnet", "id": "Q9V4C8", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9V4C8" } ], "reference": [ { "type": "PubMed", "id": "18327897", "url": "https://glygen.org/publication/PubMed/18327897" } ] }, { "title": "Drosophila Set1 is the major histone H3 lysine 4 trimethyltransferase with role in transcription.", "journal": "EMBO J.", "date": "2011", "authors": "Caron M., Mei A., Lis J.T., Kusch T., Ardehali M.B., Zobeck K.L.", "evidence": [ { "database": "UniProtKB", "id": "Q9V4C8", "url": "https://www.uniprot.org/uniprot/Q9V4C8" } ], "reference": [ { "type": "PubMed", "id": "21694722", "url": "https://glygen.org/publication/PubMed/21694722" } ] }, { "title": "The COMPASS family of H3K4 methylases in Drosophila.", "journal": "Mol. Cell. Biol.", "date": "2011", "authors": "Eissenberg J.C., Florens L., Jackson J., Shilatifard A., Smith E.R., Washburn M.P., Zhang Y., Herz H.M., Mohan M.", "evidence": [ { "database": "UniProtKB", "id": "Q9V4C8", "url": "https://www.uniprot.org/uniprot/Q9V4C8" } ], "reference": [ { "type": "PubMed", "id": "21875999", "url": "https://glygen.org/publication/PubMed/21875999" } ] }, { "title": "A mutant O-GlcNAcase as a probe to reveal global dynamics of protein O-GlcNAcylation during Drosophila embryonic development.", "journal": "The Biochemical journal", "date": "2015", "authors": "Mariappa D, Selvan N, Borodkin V, Alonso J, Ferenbach AT, Shepherd C, Navratilova IH, vanAalten DMF", "evidence": [ { "database": "O-GlcNAc Atlas", "id": "Q9V4C8", "url": "https://oglcnac.org/atlas/detail/Q9V4C8" } ], "reference": [ { "type": "PubMed", "id": "26348912", "url": "https://glygen.org/publication/PubMed/26348912" } ] }, { "title": "Genome-wide chemical mapping of O-GlcNAcylated proteins in Drosophila melanogaster.", "journal": "Nature chemical biology", "date": "2017", "authors": "Liu TW, Myschyshyn M, Sinclair DA, Cecioni S, Beja K, Honda BM, Morin RD, Vocadlo DJ", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9V4C8", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9V4C8" } ], "reference": [ { "type": "PubMed", "id": "27918560", "url": "https://glygen.org/publication/PubMed/27918560" } ] }, { "title": "A mutant O-GlcNAcase enriches Drosophila developmental regulators.", "journal": "Nature chemical biology", "date": "2017", "authors": "Selvan N, Williamson R, Mariappa D, Campbell DG, Gourlay R, Ferenbach AT, Aristotelous T, Hopkins-Navratilova I, Trost M, van Aalten DMF", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9V4C8", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9V4C8" }, { "database": "O-GlcNAc Atlas", "id": "Q9V4C8", "url": "https://oglcnac.org/atlas/detail/Q9V4C8" } ], "reference": [ { "type": "PubMed", "id": "28604694", "url": "https://glygen.org/publication/PubMed/28604694" } ] }, { "title": "Drosophila O-GlcNAcase Mutants Reveal an Expanded Glycoproteome and Novel Growth and Longevity Phenotypes.", "journal": "Cells", "date": "2021", "authors": "Akan I, Halim A, Vakhrushev SY, Clausen H, Hanover JA", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9V4C8", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9V4C8" } ], "reference": [ { "type": "PubMed", "id": "33925313", "url": "https://glygen.org/publication/PubMed/33925313" } ] } ], "pathway": [ { "id": "dme:Dmel_CG1710", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG1710", "resource": "KEGG Pathway" }, { "id": "R-DME-5689603", "name": "UCH proteinases", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-5689603", "resource": "Reactome", "description": "UCH proteinases" }, { "id": "R-DME-9772755", "name": "Formation of WDR5-containing histone-modifying complexes", "url": 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