{ "uniprot_canonical_ac": "Q9V3Z1-1", "uniprot_ac": "Q9V3Z1", "uniprot_id": "TRIB_DROME", "mass": { "chemical_mass": 54077.0, "monoisotopic_mass": 54077.0 }, "refseq": { "ac": "NP_524672", "name": "tribbles", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524672" }, "gene_names": [ { "name": "trbl", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q9V3Z1", "id": "Q9V3Z1" }, { "name": "CG5408; Dmel\\CG5408; trb; Trbl", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524672", "id": "NP_524672" }, { "name": "CG5408", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9V3Z1", "id": "Q9V3Z1" }, { "name": "trbl", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524672", "id": "NP_524672" } ], "protein_names": [ { "name": "Tribbles", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q9V3Z1" }, { "name": "CG5408-PA; trbl-PA; tribbless", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524672", "id": "NP_524672" }, { "name": "tribbles", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524672", "id": "NP_524672" } ], "function": [ { "annotation": "Adapter protein that negatively regulates different signaling pathways to coordinate cell differentiation, proliferation, migration and growth (PubMed:10837248, PubMed:10850493, PubMed:10850494, PubMed:10949024, PubMed:23305818, PubMed:25329475). Functions by binding to key regulatory proteins and either blocks their activity or regulates their turnover by the proteasome (PubMed:10837248, PubMed:10850493, PubMed:10850494, PubMed:10949024, PubMed:23305818, PubMed:25329475). In various developing tissues functions as a cell cycle regulator that mediates cell proliferation according to the requirements of the developmental program (PubMed:10850493, PubMed:10850494, PubMed:10837248, PubMed:15581871). Acts by inducing the proteasomal degradation of the CD25 mitotic activators stg and twe at critical stages of development to delay entry into mitosis and thus mediate cell proliferation (PubMed:10850493, PubMed:10850494, PubMed:10837248, PubMed:15581871, PubMed:23290551, PubMed:29025897). During gastrulation, negatively regulates stg to delay mitosis in the ventral region of the embryonic mesoderm thus allowing invagination to be completed before cell division takes place (PubMed:10837248, PubMed:10850493, PubMed:10850494). Delaying stg-dependent mitosis during bristle development and in migrating germline pole cells also arrests their cell divisions, whereas in cystocytes it promotes their cell divisions (PubMed:10837248, PubMed:10850493, PubMed:15581871). Involved in the regulation of the mid-blastula transition; promotes the destruction of twe resulting in the cell cycle arrest in G2 of cycle 14 which delays mitosis and thus reduces cell proliferation allowing cell fate specification and morphogenesis to take place (PubMed:23290551). In germline cells, blocks border cell migration during oogenesis by binding to slbo/C/EBP and promoting its ubiquitination and degradation by the proteasome (PubMed:23305818, PubMed:10949024, PubMed:29025897). May function in a negative feedback loop with slbo to coordinate proper border cell migration (PubMed:23305818). During tissue growth negatively regulates insulin signaling by binding to Akt1 and blocking its phosphorylation-dependent activation (PubMed:25329475, PubMed:29025897). However it may also function downstream in the insulin signaling pathway, acting with Akt1 to direct foxo degradation (PubMed:25329475). Essential for the proper formation of operant place and aversive olfactory memories (PubMed:18430923, PubMed:28669782).", "evidence": [ { "database": "UniProtKB", "id": "Q9V3Z1", "url": "https://www.uniprot.org/uniprot/Q9V3Z1#function" }, { "database": "PubMed", "id": "23290551", "url": "https://glygen.org/publication/PubMed/23290551" }, { "database": "PubMed", "id": "10837248", "url": "https://glygen.org/publication/PubMed/10837248" }, { "database": "PubMed", "id": "10850493", "url": "https://glygen.org/publication/PubMed/10850493" }, { "database": "PubMed", "id": "28669782", "url": "https://glygen.org/publication/PubMed/28669782" }, { "database": "PubMed", "id": "15581871", "url": "https://glygen.org/publication/PubMed/15581871" }, { "database": "PubMed", "id": "18430923", "url": "https://glygen.org/publication/PubMed/18430923" }, { "database": "PubMed", "id": "10850494", "url": "https://glygen.org/publication/PubMed/10850494" }, { "database": "PubMed", "id": "10949024", "url": "https://glygen.org/publication/PubMed/10949024" }, { "database": "PubMed", "id": "23305818", "url": "https://glygen.org/publication/PubMed/23305818" }, { "database": "PubMed", "id": "29025897", "url": "https://glygen.org/publication/PubMed/29025897" }, { "database": "PubMed", "id": "25329475", "url": "https://glygen.org/publication/PubMed/25329475" } ] } ], "disease": [ { "disease_id": "DOID:4194", "recommended_name": { "id": "DOID:4194", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4194", "name": "glucose metabolism disease", "description": "" }, "synonyms": [ { "id": "DOID:4194", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4194", "name": "disorder of glucose metabolism", "description": "" } ], "evidence": [ { "id": "4194", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:4194" } ] } ], "snv": [], "mutagenesis": [ { "start_pos": 141, "end_pos": 141, "sequence_org": "R", "sequence_mut": "E", "comment": "Increased interaction with Akt1 and some negative regulation of Atk1. Increased interaction with slbo but no effect on negative regulation of slbo-dependent border cell migration. No effect on interaction and negative regulation of stg-dependent cell divisions in the wing.", "evidence": [ { "database": "UniProtKB", "id": "Q9V3Z1", "url": "https://www.uniprot.org/uniprot/Q9V3Z1" }, { "database": "PubMed", "id": "29025897", "url": "https://glygen.org/publication/PubMed/29025897" } ] }, { "start_pos": 141, "end_pos": 141, "sequence_org": "R", "sequence_mut": "Q", "comment": "Reduced interaction and inhibition of Akt1 resulting in increased Akt1-mediated growth and loss of carbohydrate clearance from the hemolymph. No effect on interaction with slbo and stg, and no effect on the negative regulation of slbo-dependent border cell migration and stg-dependent cell divisions in the wing.", "evidence": [ { "database": "UniProtKB", "id": "Q9V3Z1", "url": "https://www.uniprot.org/uniprot/Q9V3Z1" }, { "database": "PubMed", "id": "29025897", "url": "https://glygen.org/publication/PubMed/29025897" } ] }, { "start_pos": 154, "end_pos": 154, "sequence_org": "R", "sequence_mut": "A", "comment": "Partial loss of border cell migration when expressed in border cells.", "evidence": [ { "database": "UniProtKB", "id": "Q9V3Z1", "url": "https://www.uniprot.org/uniprot/Q9V3Z1" }, { "database": "PubMed", "id": "23305818", "url": "https://glygen.org/publication/PubMed/23305818" } ] }, { "start_pos": 264, "end_pos": 264, "sequence_org": "D", "sequence_mut": "K", "comment": "Reduced interaction with Akt1 and reduced inhibition of Akt1-mediated growth. Reduced interaction with slbo and fails to block border cell migration. No effect on cell division in the posterior compartment of the wing.", "evidence": [ { "database": "UniProtKB", "id": "Q9V3Z1", "url": "https://www.uniprot.org/uniprot/Q9V3Z1" }, { "database": "PubMed", "id": "23305818", "url": "https://glygen.org/publication/PubMed/23305818" }, { "database": "PubMed", "id": "29025897", "url": "https://glygen.org/publication/PubMed/29025897" }, { "database": "PubMed", "id": "25329475", "url": "https://glygen.org/publication/PubMed/25329475" } ] }, { "start_pos": 266, "end_pos": 266, "sequence_org": "K", "sequence_mut": "R", "comment": "No effect on mitosis. Embryos display an early pause in the cell cycle similar to wild-type.", "evidence": [ { "database": "UniProtKB", "id": "Q9V3Z1", "url": "https://www.uniprot.org/uniprot/Q9V3Z1" }, { "database": "PubMed", "id": "10850494", "url": "https://glygen.org/publication/PubMed/10850494" } ] }, { "start_pos": 286, "end_pos": 286, "sequence_org": "E", "sequence_mut": "G", "comment": "Partial loss of border cell migration when expressed in border cells.", "evidence": [ { "database": "UniProtKB", "id": "Q9V3Z1", "url": "https://www.uniprot.org/uniprot/Q9V3Z1" }, { "database": "PubMed", "id": "23305818", "url": "https://glygen.org/publication/PubMed/23305818" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9V3Z1", "url": "https://www.uniprot.org/uniprot/Q9V3Z1" } ], "common_name": "Fruit fly" } ], "gene": [ { "name": "trbl", "url": "https://www.uniprot.org/uniprot/Q9V3Z1", "locus": { "chromosome": "3L", "start_pos": 20396288, "end_pos": 20401609, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "FBgn0028978", "url": "https://www.ensembl.org/id/FBgn0028978" } ] } } ], "crossref": [ { "id": "FBgn0028978", "url": "https://bgee.org/?page=gene&gene_id=FBgn0028978", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "FBgn0028978", "url": "https://flybase.org/reports/FBgn0028978", "database": "FlyBase", "categories": [ "Organism-specific" ] }, { "id": "43999", "url": "https://www.ncbi.nlm.nih.gov/gene/43999", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q9V3Z1", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q9V3Z1*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024104", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024104", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dme:Dmel_CG5408", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG5408", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FYFIDEA", "url": "https://omabrowser.org/oma/group/FYFIDEA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2937186at2759", "url": "http://www.orthodb.org/?query=2937186at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22961", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22961", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22961:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22961:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00069", "url": "http://pfam.xfam.org/family/PF00069", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q9V3Z1", "url": "http://purl.obolibrary.org/obo/PR_Q9V3Z1", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-DME-1257604", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-1257604", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DME-165158", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-165158", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DME-199418", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-199418", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DME-389357", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-389357", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DME-5218920", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-5218920", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_524672", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524672", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q9V3Z1", "url": "https://www.uniprot.org/uniprot/Q9V3Z1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9V3Z1-1", "url": "https://www.uniprot.org/uniprot/Q9V3Z1-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDNSSGQNSRTASSASTSKIVNYSSPVSPGVAAATSSSSSSSSSGMSSSQEDTVLGLFTPKKEFPNAKMLQTIREKLMTPGGACDLLALGIAAEPTDQQPVKLIQQRYLISAQPSHISAAVAAKTPASYRHLVDLTASNLRCVDIFTGEQFLCRIVNEPLHKVQRAYFQLQQHDEELRRSTIYGHPLIRPVHDIIPLTKDRTYILIAPVPQERDSTGGVTGVYENLHTYIRHAKRLCETEARAIFHQICQTVQVCHRNGIILRDLKLKRFYFIDEARTKLQYESLEGSMILDGEDDTLSDKIGCPLYTAPELLCPQQTYKGKPADMWSLGVILYTMLVGQYPFYEKANCNLITVIRHGNVQIPLTLSKSVRWLLLSLLRKDYTERMTASHIFLTPWLREQRPFHMYLPVDVEVAEDWSDAEEDEGTAADAMDDDEEGLCPLGDKHEYEDIGVEPLDYTRSTLQMAQNANGLSTEPEPDTDVDMG", "length": 484, "header": "sp|Q9V3Z1-1|TRIB_DROME Isoform 1 of Tribbles OS=Drosophila melanogaster OX=7227 GN=trbl PE=1 SV=1 CANONICAL=Q9V3Z1-1" }, "isoforms": [ { "isoform_ac": "Q9V3Z1-1", "url": "", "sequence": { "sequence": "MDNSSGQNSRTASSASTSKIVNYSSPVSPGVAAATSSSSSSSSSGMSSSQEDTVLGLFTPKKEFPNAKMLQTIREKLMTPGGACDLLALGIAAEPTDQQPVKLIQQRYLISAQPSHISAAVAAKTPASYRHLVDLTASNLRCVDIFTGEQFLCRIVNEPLHKVQRAYFQLQQHDEELRRSTIYGHPLIRPVHDIIPLTKDRTYILIAPVPQERDSTGGVTGVYENLHTYIRHAKRLCETEARAIFHQICQTVQVCHRNGIILRDLKLKRFYFIDEARTKLQYESLEGSMILDGEDDTLSDKIGCPLYTAPELLCPQQTYKGKPADMWSLGVILYTMLVGQYPFYEKANCNLITVIRHGNVQIPLTLSKSVRWLLLSLLRKDYTERMTASHIFLTPWLREQRPFHMYLPVDVEVAEDWSDAEEDEGTAADAMDDDEEGLCPLGDKHEYEDIGVEPLDYTRSTLQMAQNANGLSTEPEPDTDVDMG", "length": 484, "header": "sp|Q9V3Z1-1|TRIB_DROME Isoform 1 of Tribbles OS=Drosophila melanogaster OX=7227 GN=trbl PE=1 SV=1 CANONICAL=Q9V3Z1-1" }, "locus": { "chromosome": "3L", "start_pos": 20401255, "end_pos": 20396854, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0078235", "url": "https://www.ensembl.org/id/FBtr0078235" }, { "database": "Ensembl Peptide", "id": "FBpp0077893", "url": "https://www.ensembl.org/id/FBpp0077893" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "The genome sequence of Drosophila melanogaster.", "journal": "Science", "date": "2000", "authors": "Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA, Galle RF, George RA, Lewis SE, Richards S, Ashburner M, Henderson SN, Sutton GG, Wortman JR, Yandell MD, Zhang Q, Chen LX, Brandon RC, Rogers YH, Blazej RG, Champe M, Pfeiffer BD, Wan KH, Doyle C, Baxter EG, Helt G, Nelson CR, Gabor GL, Abril JF, Agbayani A, An HJ, Andrews-Pfannkoch C, Baldwin D, Ballew RM, Basu A, Baxendale J, Bayraktaroglu L, Beasley EM, Beeson KY, Benos PV, Berman BP, Bhandari D, Bolshakov S, Borkova D, Botchan MR, Bouck J, Brokstein P, Brottier P, Burtis KC, Busam DA, Butler H, Cadieu E, Center A, Chandra I, Cherry JM, Cawley S, Dahlke C, Davenport LB, Davies P, de Pablos B, Delcher A, Deng Z, Mays AD, Dew I, Dietz SM, Dodson K, Doup LE, Downes M, Dugan-Rocha S, Dunkov BC, Dunn P, Durbin KJ, Evangelista CC, Ferraz C, Ferriera S, Fleischmann W, Fosler C, Gabrielian AE, Garg NS, Gelbart WM, Glasser K, Glodek A, Gong F, Gorrell JH, Gu Z, Guan P, Harris M, Harris NL, Harvey D, Heiman TJ, Hernandez JR, Houck J, Hostin D, Houston KA, Howland TJ, Wei MH, Ibegwam C, Jalali M, Kalush F, Karpen GH, Ke Z, Kennison JA, Ketchum KA, Kimmel BE, Kodira CD, Kraft C, Kravitz S, Kulp D, Lai Z, Lasko P, Lei Y, Levitsky AA, Li J, Li Z, Liang Y, Lin X, Liu X, Mattei B, McIntosh TC, McLeod MP, McPherson D, Merkulov G, Milshina NV, Mobarry C, Morris J, Moshrefi A, Mount SM, Moy M, Murphy B, Murphy L, Muzny DM, Nelson DL, Nelson DR, Nelson KA, Nixon K, Nusskern DR, Pacleb JM, Palazzolo M, Pittman GS, Pan S, Pollard J, Puri V, Reese MG, Reinert K, Remington K, Saunders RD, Scheeler F, Shen H, Shue BC, Siden-Kiamos I, Simpson M, Skupski MP, Smith T, Spier E, Spradling AC, Stapleton M, Strong R, Sun E, Svirskas R, Tector C, Turner R, Venter E, Wang AH, Wang X, Wang ZY, Wassarman DA, Weinstock GM, Weissenbach J, Williams SM, WoodageT, Worley KC, Wu D, Yang S, Yao QA, Ye J, Yeh RF, Zaveri JS, Zhan M, Zhang G, Zhao Q, Zheng L, Zheng XH, Zhong FN, Zhong W, Zhou X, Zhu S, Zhu X, Smith HO, Gibbs RA, Myers EW, Rubin GM, Venter JC", "evidence": [ { "database": "UniProtKB", "id": "Q9V3Z1", "url": "https://www.uniprot.org/uniprot/Q9V3Z1" } ], "reference": [ { "type": "PubMed", "id": "10731132", "url": "https://glygen.org/publication/PubMed/10731132" } ] }, { "title": "Tribbles, a cell cycle brake that coordinates proliferation and morphogenesis during Drosophila gastrulation.", "journal": "Curr. Biol.", "date": "2000", "authors": "Leptin M., Seher T.C.", "evidence": [ { "database": "UniProtKB", "id": "Q9V3Z1", "url": "https://www.uniprot.org/uniprot/Q9V3Z1" } ], "reference": [ { "type": "PubMed", "id": "10837248", "url": "https://glygen.org/publication/PubMed/10837248" } ] }, { "title": "Tribbles coordinates mitosis and morphogenesis in Drosophila by regulating string/CDC25 proteolysis.", "journal": "Cell", "date": "2000", "authors": "Curado S., Ephrussi A., Roerth P., Mata J.", "evidence": [ { "database": "UniProtKB", "id": "Q9V3Z1", "url": "https://www.uniprot.org/uniprot/Q9V3Z1" } ], "reference": [ { "type": "PubMed", "id": "10850493", "url": "https://glygen.org/publication/PubMed/10850493" } ] }, { "title": "A genetic link between morphogenesis and cell division during formation of the ventral furrow in Drosophila.", "journal": "Cell", "date": "2000", "authors": "Grosshans J, Wieschaus E", "evidence": [ { "database": "UniProtKB", "id": "Q9V3Z1", "url": "https://www.uniprot.org/uniprot/Q9V3Z1" } ], "reference": [ { "type": "PubMed", "id": "10850494", "url": "https://glygen.org/publication/PubMed/10850494" } ] }, { "title": "The level of C/EBP protein is critical for cell migration during Drosophila oogenesis and is tightly controlled by regulated degradation.", "journal": "Mol. Cell", "date": "2000", "authors": "Rorth P, Szabo K, Texido G", "evidence": [ { "database": "UniProtKB", "id": "Q9V3Z1", "url": "https://www.uniprot.org/uniprot/Q9V3Z1" } ], "reference": [ { "type": "PubMed", "id": "10949024", "url": "https://glygen.org/publication/PubMed/10949024" } ] }, { "title": "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.", "journal": "Genome Biol.", "date": "2002", "authors": "Misra S, Crosby MA, Mungall CJ, Matthews BB, Campbell KS, Hradecky P, Huang Y, Kaminker JS, Millburn GH, Prochnik SE, Smith CD, Tupy JL, Whitfied EJ, Bayraktaroglu L, Berman BP, Bettencourt BR, Celniker SE, de Grey AD, Drysdale RA, Harris NL, Richter J, Russo S, Schroeder AJ, Shu SQ, Stapleton M, Yamada C, Ashburner M, Gelbart WM, Rubin GM, Lewis SE", "evidence": [ { "database": "UniProtKB", "id": "Q9V3Z1", "url": "https://www.uniprot.org/uniprot/Q9V3Z1" } ], "reference": [ { "type": "PubMed", "id": "12537572", "url": "https://glygen.org/publication/PubMed/12537572" } ] }, { "title": "Mother-daughter precursor cell fate transformation after Cdc2 down-regulation in the Drosophila bristle lineage.", "journal": "Dev. Biol.", "date": "2004", "authors": "Gho M., Fichelson P.", "evidence": [ { "database": "UniProtKB", "id": "Q9V3Z1", "url": "https://www.uniprot.org/uniprot/Q9V3Z1" } ], "reference": [ { "type": "PubMed", "id": "15581871", "url": "https://glygen.org/publication/PubMed/15581871" } ] }, { "title": "Genetic dissociation of ethanol sensitivity and memory formation in Drosophila melanogaster.", "journal": "Genetics", "date": "2008", "authors": "Heberlein U., Diegelmann S., Guarnieri D.J., LaFerriere H., Zars T., Sitaraman D.", "evidence": [ { "database": "UniProtKB", "id": "Q9V3Z1", "url": "https://www.uniprot.org/uniprot/Q9V3Z1" } ], "reference": [ { "type": "PubMed", "id": "18430923", "url": "https://glygen.org/publication/PubMed/18430923" } ] }, { "title": "Mechanism and regulation of Cdc25/Twine protein destruction in embryonic cell-cycle remodeling.", "journal": "Curr. Biol.", "date": "2013", "authors": "O'Farrell P.H., Farrell J.A.", "evidence": [ { "database": "UniProtKB", "id": "Q9V3Z1", "url": "https://www.uniprot.org/uniprot/Q9V3Z1" } ], "reference": [ { "type": "PubMed", "id": "23290551", "url": "https://glygen.org/publication/PubMed/23290551" } ] }, { "title": "The kinase domain of Drosophila Tribbles is required for turnover of fly C/EBP during cell migration.", "journal": "Dev. Biol.", "date": "2013", "authors": "Masoner V, Das R, Pence L, Anand G, LaFerriere H, Zars T, Bouyain S, Dobens LL", "evidence": [ { "database": "UniProtKB", "id": "Q9V3Z1", "url": "https://www.uniprot.org/uniprot/Q9V3Z1" } ], "reference": [ { "type": "PubMed", "id": "23305818", "url": "https://glygen.org/publication/PubMed/23305818" } ] }, { "title": "Drosophila tribbles antagonizes insulin signaling-mediated growth and metabolism via interactions with Akt kinase.", "journal": "PLoS ONE", "date": "2014", "authors": "Das R, Sebo Z, Pence L, Dobens LL", "evidence": [ { "database": "UniProtKB", "id": "Q9V3Z1", "url": "https://www.uniprot.org/uniprot/Q9V3Z1" } ], "reference": [ { "type": "PubMed", "id": "25329475", "url": "https://glygen.org/publication/PubMed/25329475" } ] }, { "title": "The Drosophila melanogaster tribbles pseudokinase is necessary for proper memory formation.", "journal": "Neurobiol. Learn. Mem.", "date": "2017", "authors": "LaFerriere H., Zars T.", "evidence": [ { "database": "UniProtKB", "id": "Q9V3Z1", "url": "https://www.uniprot.org/uniprot/Q9V3Z1" } ], "reference": [ { "type": "PubMed", "id": "28669782", "url": "https://glygen.org/publication/PubMed/28669782" } ] }, { "title": "A Drosophila model of insulin resistance associated with the human Trib3 Q/R polymorphism.", "journal": "Dis. Model. 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