{ "uniprot_canonical_ac": "Q9UPN9-1", "uniprot_ac": "Q9UPN9", "uniprot_id": "TRI33_HUMAN", "mass": { "chemical_mass": 122533.0, "monoisotopic_mass": 122533.0 }, "refseq": { "ac": "NP_056990", "name": "E3 ubiquitin-protein ligase TRIM33 isoform alpha", "summary": "The protein encoded by this gene is thought to be a transcriptional corepressor. However, molecules that interact with this protein have not yet been identified. The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056990" }, "gene_names": [ { "name": "TRIM33", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q9UPN9", "id": "Q9UPN9" }, { "name": "ECTO; PTC7; RFG7; TF1G; TIF1G; TIF1GAMMA; TIFGAMMA", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056990", "id": "NP_056990" }, { "name": "KIAA1113", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9UPN9", "id": "Q9UPN9" }, { "name": "RFG7", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9UPN9", "id": "Q9UPN9" }, { "name": "TIF1G", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9UPN9", "id": "Q9UPN9" }, { "name": "TRIM33", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056990", "id": "NP_056990" } ], "protein_names": [ { "name": "E3 ubiquitin-protein ligase TRIM33", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q9UPN9" }, { "name": "2.3.2.27", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9UPN9" }, { "name": "E3 ubiquitin-protein ligase TRIM33 isoform alpha", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056990", "id": "NP_056990" }, { "name": "Ectodermin homolog", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9UPN9" }, { "name": "Protein Rfg7", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9UPN9" }, { "name": "RET-fused gene 7 protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9UPN9" }, { "name": "RING-type E3 ubiquitin transferase TRIM33", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9UPN9" }, { "name": "TIF1-gamma", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9UPN9" }, { "name": "Transcription intermediary factor 1-gamma", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9UPN9" }, { "name": "Tripartite motif-containing protein 33", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9UPN9" }, { "name": "transcriptional intermediary factor 1 gamma; E3 ubiquitin-protein ligase TRIM33; TIF1-gamma; protein Rfg7; ectodermin homolog; RET-fused gene 7 protein; RING-type E3 ubiquitin transferase TRIM33", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056990", "id": "NP_056990" } ], "function": [ { "annotation": "Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).", "evidence": [ { "database": "UniProtKB", "id": "Q9UPN9", "url": "https://www.uniprot.org/uniprot/Q9UPN9#function" }, { "database": "PubMed", "id": "19135894", "url": "https://glygen.org/publication/PubMed/19135894" }, { "database": "PubMed", "id": "15820681", "url": "https://glygen.org/publication/PubMed/15820681" }, { "database": "PubMed", "id": "10022127", "url": "https://glygen.org/publication/PubMed/10022127" }, { "database": "PubMed", "id": "16751102", "url": "https://glygen.org/publication/PubMed/16751102" } ] }, { "annotation": "Downregulation of TRIM33 Promotes Survival and Epithelial-Mesenchymal Transition in Gastric Cancer.", "evidence": [ { "database": "RefSeq", "id": "NP_056990", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056990" }, { "database": "PubMed", "id": "35929141", "url": "https://glygen.org/publication/PubMed/35929141" } ] }, { "annotation": "E3 ubiquitin ligase Trim33 ubiquitylates Annexin A2 to promote NF-kappaB induced skin inflammation in psoriasis.", "evidence": [ { "database": "RefSeq", "id": "NP_056990", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056990" }, { "database": "PubMed", "id": "36096861", "url": "https://glygen.org/publication/PubMed/36096861" } ] }, { "annotation": "KAT6A Acetylation of SMAD3 Regulates Myeloid-Derived Suppressor Cell Recruitment, Metastasis, and Immunotherapy in Triple-Negative Breast Cancer. Erratum:[Adv Sci (Weinh). 2022 Jan;9(3):e2105793. PMID: 35075800]", "evidence": [ { "database": "RefSeq", "id": "NP_056990", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056990" }, { "database": "PubMed", "id": "34392614", "url": "https://glygen.org/publication/PubMed/34392614" } ] }, { "annotation": "TIF1alpha interacts with TIF1gamma and the coiled-coil region of TIF1gamma is necessary for this interaction.", "evidence": [ { "database": "RefSeq", "id": "NP_056990", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056990" }, { "database": "PubMed", "id": "12096914", "url": "https://glygen.org/publication/PubMed/12096914" } ] }, { "annotation": "TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.", "evidence": [ { "database": "RefSeq", "id": "NP_056990", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056990" }, { "database": "PubMed", "id": "35785414", "url": "https://glygen.org/publication/PubMed/35785414" } ] }, { "annotation": "The protein encoded by this gene is thought to be a transcriptional corepressor. However, molecules that interact with this protein have not yet been identified. The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_056990", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056990" } ] }, { "annotation": "Thus, Smad2/3-TIF1gamma and Smad2/3-Smad4 function as complementary effector arms in the control of hematopoietic cell fate by the TGFbeta/Smad pathway.", "evidence": [ { "database": "RefSeq", "id": "NP_056990", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056990" }, { "database": "PubMed", "id": "16751102", "url": "https://glygen.org/publication/PubMed/16751102" } ] }, { "annotation": "Tubular cell transcriptional intermediary factor 1gamma deficiency exacerbates kidney injury-induced tubular cell polyploidy and fibrosis.", "evidence": [ { "database": "RefSeq", "id": "NP_056990", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056990" }, { "database": "PubMed", "id": "37482091", "url": "https://glygen.org/publication/PubMed/37482091" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs1572003243", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1572003243" }, { "id": "rs1572003243", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1572003243" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 1013, "end_pos": 1013, "sequence_org": "K", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (KHS->NHS).", "chr_id": "1", "chr_pos": "114399538", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "K1013", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "Q9UPN9", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9UPN9" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 249, "end_pos": 249, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "K", "sequence_mut": "N", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (KFT->NFT).", "chr_id": "1", "chr_pos": "114463455", "ref_nt": "T", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "K249", "disease": [ { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "rs773729333", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs773729333" }, { "id": "rs773729333", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs773729333" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 456, "end_pos": 456, "sequence_org": "A", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NGA->NGS).", "chr_id": "1", "chr_pos": "114427231", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "A456", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "Q9UPN9", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9UPN9" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 456, "end_pos": 456, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "A", "sequence_mut": "T", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (NGA->NGT).", "chr_id": "1", "chr_pos": "114427231", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "A456", "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "rs1046497161", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1046497161" }, { "id": "rs1046497161", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1046497161#frequency_tab" }, { "id": "rs1046497161", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1046497161" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 638, "end_pos": 638, "sequence_org": "T", "sequence_mut": "P", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->P).", "chr_id": "1", "chr_pos": "114421585", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T638", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs760467255", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs760467255" }, { "id": "rs760467255", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs760467255" }, { "id": "rs760467255", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs760467255" } ], "glycoeffect": [ "n-glyco-sequon-loss", 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"name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, 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"http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", 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"MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Head and neck cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "Q9UPN9", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q9UPN9" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ] } ] }, { "significant": "No", "trend": "up", "name": "Lung cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1324", "evidence": [ { "database": "BioXpress", "id": "Q9UPN9", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q9UPN9" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": 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{ "id": "PF00643", "url": "http://pfam.xfam.org/family/PF00643", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13445", "url": "http://pfam.xfam.org/family/PF13445", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "Q9UPN9", "url": "https://pharos.nih.gov/targets/Q9UPN9", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_Q9UPN9", "url": "http://purl.obolibrary.org/obo/PR_Q9UPN9", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-2173795", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2173795", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-9754189", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9754189", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_056990", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056990", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "H0Y612", "url": "https://www.uniprot.org/uniprot/H0Y612", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0Y612-1", "url": "https://www.uniprot.org/uniprot/H0Y612-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9UPN9", "url": "https://www.uniprot.org/uniprot/Q9UPN9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9UPN9-1", "url": "https://www.uniprot.org/uniprot/Q9UPN9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9UPN9-2", "url": "https://www.uniprot.org/uniprot/Q9UPN9-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGPDDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIPGGSNGDIQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCIEAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIASGSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGIPRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQLEDAGSSSLDNLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPGTEDEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKIEPADMNESCKQSGLSSLVNGKSPIRSLMHRSARIGGDGNNKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSPVDQRKCERLLLYLYCHELSIEFQEPVPASIPNYYKIIKKPMDLSTVKKKLQKKHSQHYQIPDDFVADVRLIFKNCERFNEMMKVVQVYADTQEINLKADSEVAQAGKAVALYFEDKLTEIYSDRTFAPLPEFEQEEDDGEVTEDSDEDFIQPRRKRLKSDERPVHIK", "length": 1127, "header": "sp|Q9UPN9-1|TRI33_HUMAN Isoform 1 of E3 ubiquitin-protein ligase TRIM33 OS=Homo sapiens OX=9606 GN=TRIM33 PE=1 SV=3 CANONICAL=Q9UPN9-1" }, "isoforms": [ { "isoform_ac": "H0Y612-1", "url": "", "sequence": { "sequence": "XSVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIASGSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGIPRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQANVVPMMHSWYEFGAREKTQDQNVLEDAGSSSLDNLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPGTEDEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKIEPADMNESCKQSGLSSLVNGKSPIRSLMHRSARIGGDGNNKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSPVDQRKCERLLLYLYCHELSIEFQEPVPASIPNYYKIIKKPMDLSTVKKKLQKKHSQHYQIPDDFVADVRLIFKNCERFNEMMKVVQVYADTQEINLKADSEVAQAGKAVALYFEDKLTEIYSDRTFAPLPEFEQEEDDGEVTEDSDEDFIQPRRKRLKSDERPVHIK", "length": 888, "header": "tr|H0Y612-1|TRI33_HUMAN Computationally mapped isoform of E3 ubiquitin-protein ligase TRIM33 OS=Homo sapiens OX=9606 GN=TRIM33 PE=1 SV=1 CANONICAL=Q9UPN9-1" }, "locus": { "chromosome": "1", "start_pos": 114463236, "end_pos": 114397650, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000448034.5", "url": "https://www.ensembl.org/id/ENST00000448034.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000402333.1", "url": "https://www.ensembl.org/id/ENSP00000402333.1" } ] } }, { "isoform_ac": "Q9UPN9-1", "url": "", "sequence": { "sequence": "MAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGPDDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIPGGSNGDIQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCIEAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIASGSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGIPRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQLEDAGSSSLDNLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPGTEDEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKIEPADMNESCKQSGLSSLVNGKSPIRSLMHRSARIGGDGNNKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSPVDQRKCERLLLYLYCHELSIEFQEPVPASIPNYYKIIKKPMDLSTVKKKLQKKHSQHYQIPDDFVADVRLIFKNCERFNEMMKVVQVYADTQEINLKADSEVAQAGKAVALYFEDKLTEIYSDRTFAPLPEFEQEEDDGEVTEDSDEDFIQPRRKRLKSDERPVHIK", "length": 1127, "header": "sp|Q9UPN9-1|TRI33_HUMAN Isoform 1 of E3 ubiquitin-protein ligase TRIM33 OS=Homo sapiens OX=9606 GN=TRIM33 PE=1 SV=3 CANONICAL=Q9UPN9-1" }, "locus": { "chromosome": "1", "start_pos": 114511076, "end_pos": 114397651, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000358465.7", "url": "https://www.ensembl.org/id/ENST00000358465.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000351250.2", "url": "https://www.ensembl.org/id/ENSP00000351250.2" } ] } }, { "isoform_ac": "Q9UPN9-2", "url": "", "sequence": { "sequence": "MAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAAGPDDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIPGGSNGDIQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCIEAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIASGSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRMQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGIPRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQLEDAGSSSLDNLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPGTEDEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKIEPADMNESCKQSGLSSLVNGKSPIRSLMHRSARIGGDGNNKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSPVDQRKCERLLLYLYCHELSIEFQEPVPASIPNYYKIIKKPMDLSTVKKKLQKKHSQHYQIPDDFVADVRLIFKNCERFNEADSEVAQAGKAVALYFEDKLTEIYSDRTFAPLPEFEQEEDDGEVTEDSDEDFIQPRRKRLKSDERPVHIK", "length": 1110, "header": "sp|Q9UPN9-2|TRI33_HUMAN Isoform 2 of E3 ubiquitin-protein ligase TRIM33 OS=Homo sapiens OX=9606 GN=TRIM33 PE=1 SV=3 CANONICAL=Q9UPN9-1" }, "locus": { "chromosome": "1", "start_pos": 114511076, "end_pos": 114397651, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000369543.6", "url": "https://www.ensembl.org/id/ENST00000369543.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000358556.2", "url": "https://www.ensembl.org/id/ENSP00000358556.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 634, "start_aa": "Ser", "end_pos": 634, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser634", "evidence": [ { "id": "Q9UPN9", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9UPN9" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "35138101", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35138101" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "32574038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32574038" }, { "id": "34725712", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34725712" }, { "id": "35132862", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35132862" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "35083852", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35083852" }, { "id": "32119511", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32119511" }, { "id": "28510447", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28510447" }, { "id": "29237092", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29237092" }, { "id": "Q9UPN9", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q9UPN9" }, { "id": "32938750", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32938750" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 638, "start_aa": "Thr", "end_pos": 638, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr638", "evidence": [ { "id": "Q9UPN9", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9UPN9" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "35138101", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35138101" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "32574038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32574038" }, { "id": "34725712", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34725712" }, { "id": "35132862", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35132862" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "35083852", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35083852" }, { "id": "32119511", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32119511" }, { "id": "28510447", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28510447" }, { "id": "29237092", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29237092" }, { "id": "Q9UPN9", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q9UPN9" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 639, "start_aa": "Thr", "end_pos": 639, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr639", "evidence": [ { "id": "Q9UPN9", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q9UPN9" }, { "id": "32574038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32574038" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 643, "start_aa": "Thr", "end_pos": 643, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr643", "evidence": [ { "id": "Q9UPN9", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9UPN9" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "35138101", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35138101" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "32574038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32574038" }, { "id": "34725712", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34725712" }, { "id": "35132862", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35132862" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "35083852", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35083852" }, { "id": "32119511", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32119511" }, { "id": "28510447", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28510447" }, { "id": "29237092", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29237092" } ] } ], "phosphorylation": [ { "start_pos": 1048, "end_pos": 1048, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q9UPN9", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9UPN9" }, { "database": "PubMed", "id": "30177833", "url": "https://glygen.org/publication/PubMed/30177833" } ], "site_lbl": "Tyr1048" }, { "start_pos": 1051, "end_pos": 1051, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q9UPN9", "url": 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Biol.", "date": "2002", "authors": "Peng H, Feldman I, Rauscher FJ 3rd", "evidence": [ { "database": "UniProtKB", "id": "Q9UPN9", "url": "https://www.uniprot.org/uniprot/Q9UPN9" }, { "database": "RefSeq", "id": "NP_056990", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056990" } ], "reference": [ { "type": "PubMed", "id": "12096914", "url": "https://glygen.org/publication/PubMed/12096914" } ] }, { "title": "Differences between human and mouse embryonic stem cells.", "journal": "Developmental biology", "date": "2004", "authors": "Ginis I, Luo Y, Miura T, Thies S, Brandenberger R, Gerecht-Nir S, Amit M, Hoke A, Carpenter MK, Itskovitz-Eldor J, Rao MS", "evidence": [ { "database": "Reactome", "id": "R-HSA-9754189", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9754189" } ], "reference": [ { "type": "PubMed", "id": "15110706", "url": "https://glygen.org/publication/PubMed/15110706" } ] }, { "title": "Germ-layer specification and control of cell growth by Ectodermin, a Smad4 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Aoyama K, Honda T, Kubota S, Morii M, Manabe I, Kuga T, Tomonaga T, Yamaguchi N", "evidence": [ { "database": "iPTMnet", "id": "Q9UPN9", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9UPN9" } ], "reference": [ { "type": "PubMed", "id": "30177833", "url": "https://glygen.org/publication/PubMed/30177833" } ] }, { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9UPN9", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9UPN9" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "Engineering a Proximity-Directed O-GlcNAc Transferase for Selective Protein O-GlcNAcylation in Cells.", "journal": "ACS chemical biology", "date": "2020", "authors": "Ramirez DH, Aonbangkhen C, Wu HY, Naftaly JA, Tang S, O'Meara TR, Woo CM", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9UPN9", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9UPN9" } ], "reference": [ { "type": "PubMed", "id": "32119511", "url": "https://glygen.org/publication/PubMed/32119511" } ] }, { "title": "TATA box-binding protein-related factor 3 drives the mesendoderm specification of human embryonic stem cells by globally interacting with the TATA box of key mesendodermal genes.", "journal": "Stem cell research & therapy", "date": "2020", "authors": "Liang H, Zhang P, Bai HJ, Huang J, Yang HT", "evidence": [ { "database": "Reactome", "id": "R-HSA-9754189", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9754189" } ], "reference": [ { "type": "PubMed", "id": "32448362", "url": "https://glygen.org/publication/PubMed/32448362" } ] }, { "title": "A Chemoenzymatic Method Based on Easily Accessible Enzymes for Profiling Protein O-GlcNAcylation.", "journal": "Analytical chemistry", "date": "2020", "authors": "Xu S, Sun F, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9UPN9", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9UPN9" }, { "database": "O-GlcNAc Atlas", "id": "Q9UPN9", "url": "https://oglcnac.org/atlas/detail/Q9UPN9" } ], "reference": [ { "type": "PubMed", "id": "32574038", "url": "https://glygen.org/publication/PubMed/32574038" } ] }, { "title": "Methods for Enrichment and Assignment of N-Acetylglucosamine Modification Sites.", "journal": "Molecular & cellular proteomics : MCP", "date": "2021", "authors": "Maynard JC, Chalkley RJ", "evidence": [ { "database": "O-GlcNAc Atlas", "id": "Q9UPN9", "url": "https://oglcnac.org/atlas/detail/Q9UPN9" } ], "reference": [ { "type": "PubMed", "id": "32938750", "url": "https://glygen.org/publication/PubMed/32938750" } ] }, { "title": "Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response.", "journal": "Nature communications", "date": "2020", "authors": "Liu Y, Chen Q, Zhang N, Zhang K, Dou T, Cao Y, Liu Y, Li K, Hao X, Xie X, Li W, Ren Y, Zhang J", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9UPN9", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9UPN9" } ], "reference": [ { "type": "PubMed", "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.", "journal": "Biochimica et biophysica acta. General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9UPN9", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9UPN9" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "KAT6A Acetylation of SMAD3 Regulates Myeloid-Derived Suppressor Cell Recruitment, Metastasis, and Immunotherapy in Triple-Negative Breast Cancer.", "journal": "Advanced science (Weinheim, Baden-Wurttemberg, Germany)", "date": "2021", "authors": "Yu B, Luo F, Sun B, Liu W, Shi Q, Cheng SY, Chen C, Chen G, Li Y, Feng H", "evidence": [ { "database": "RefSeq", "id": "NP_056990", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056990" } ], "reference": [ { "type": "PubMed", "id": "34392614", "url": "https://glygen.org/publication/PubMed/34392614" } ] }, { "title": "Truncation of the TPR domain of OGT alters substrate and glycosite selection.", "journal": "Analytical and bioanalytical chemistry", "date": "2021", "authors": "Ramirez DH, Yang B, D'Souza AK, Shen D, Woo CM", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9UPN9", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9UPN9" } ], "reference": [ { "type": "PubMed", "id": "34725712", "url": "https://glygen.org/publication/PubMed/34725712" } ] }, { "title": "O-GlcNAcylation promotes fatty acid synthase activity under nutritional stress as a pro-survival mechanism in cancer cells.", "journal": "Proteomics", "date": "2022", "authors": "Wong YK, Wang J, Lim TK, Lin Q, Yap CT, Shen HM", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9UPN9", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9UPN9" } ], "reference": [ { "type": "PubMed", "id": "35083852", "url": "https://glygen.org/publication/PubMed/35083852" } ] }, { "title": "Simultaneously Identifying and Distinguishing Glycoproteins with O-GlcNAc and O-GalNAc (the Tn Antigen) in Human Cancer Cells.", "journal": "Analytical chemistry", "date": "2022", "authors": "Xu S, Zheng J, Xiao H, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9UPN9", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9UPN9" } ], "reference": [ { "type": "PubMed", "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862" } ] }, { "title": "Spatiotemporal Activation of Protein O-GlcNAcylation in Living Cells.", "journal": "Journal of the American Chemical Society", "date": "2022", "authors": "He J, Fan Z, Tian Y, Yang W, Zhou Y, Zhu Q, Zhang W, Qin W, Yi W", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9UPN9", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9UPN9" } ], "reference": [ { "type": "PubMed", "id": "35138101", "url": "https://glygen.org/publication/PubMed/35138101" } ] }, { "title": "An Optimized Isotopic Photocleavable Tagging Strategy for Site-Specific and Quantitative Profiling of Protein O-GlcNAcylation in Colorectal Cancer Metastasis.", "journal": "ACS chemical biology", "date": "2022", "authors": "Liu J, Hao Y, Wang C, Jin Y, Yang Y, Gu J, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9UPN9", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9UPN9" } ], "reference": [ { "type": "PubMed", "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053" } ] }, { "title": "TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.", "journal": "EMBO reports", "date": "2022", "authors": "Chen M, Lingadahalli S, Narwade N, Lei KMK, Liu S, Zhao Z, Zheng Y, Lu Q, Tang AHN, Poon TCW, Cheung E", "evidence": [ { "database": "RefSeq", "id": "NP_056990", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056990" } ], "reference": [ { "type": "PubMed", "id": "35785414", "url": "https://glygen.org/publication/PubMed/35785414" } ] }, { "title": "Downregulation of TRIM33 Promotes Survival and Epithelial-Mesenchymal Transition in Gastric Cancer.", "journal": "Technology in cancer research & treatment", "date": "2022", "authors": "Wang F, Wang W, Wu X, Tang C, Du F, Lu Z, Zhang Z, Xu H, Cao X, Li PA", "evidence": [ { "database": "RefSeq", "id": "NP_056990", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056990" } ], "reference": [ { "type": "PubMed", "id": "35929141", "url": "https://glygen.org/publication/PubMed/35929141" } ] }, { "title": "E3 ubiquitin ligase Trim33 ubiquitylates Annexin A2 to promote NF-\u03baB induced skin inflammation in psoriasis.", "journal": "Journal of dermatological science", "date": "2022-09", "authors": "Zhang Jie, Zhu Jiuling, Chen Xiaowen, Xia Haibin, Yang Luting", "evidence": [ { "database": "RefSeq", "id": "NP_056990", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056990" } ], "reference": [ { "type": "PubMed", "id": "36096861", "url": "https://glygen.org/publication/PubMed/36096861" } ] }, { "title": "Tubular cell transcriptional intermediary factor 1\u03b3 deficiency exacerbates kidney injury-induced tubular cell polyploidy and fibrosis.", "journal": "Kidney international", "date": "2023-10", "authors": "Yuan Chaoyi, Jin Guannan, Li Pengcheng, Wang Wei, Ge Chang, Pan Yonglong, Zhang Qiaofeng, Mo Jie, Kuang Dong, Liu Liu, Zhang Xuewu, Liang Huifang, Zhang Wanguang, Tang Xi, Li Zifu, Liu Jihong, Xu Gang, Chen Xiaoping, Ding Ze-Yang, Zhang Bixiang", "evidence": [ { "database": "RefSeq", "id": "NP_056990", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056990" } ], "reference": [ { "type": "PubMed", "id": "37482091", "url": "https://glygen.org/publication/PubMed/37482091" } ] }, { "title": "Negative autoregulation of the organizer-specific homeobox gene goosecoid.", "journal": "The Journal of biological chemistry", "date": "1998", "authors": "Danilov V, Blum M, Schweickert A, Campione M, Steinbeisser H", "evidence": [ { "database": "Reactome", "id": "R-HSA-9754189", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9754189" } ], "reference": [ { "type": "PubMed", "id": "9417125", "url": "https://glygen.org/publication/PubMed/9417125" } ] } ], "pathway": [ { "id": "hsa:51592", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:51592", "resource": "KEGG Pathway" }, { "id": "R-HSA-2173795", "name": "Downregulation of SMAD2/3:SMAD4 transcriptional activity", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2173795", "resource": "Reactome", "description": "Downregulation of SMAD2/3:SMAD4 transcriptional activity" }, { "id": "R-HSA-9754189", "name": "Germ layer formation at gastrulation", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9754189", "resource": "Reactome", "description": "Germ layer formation at gastrulation" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZUK4-1", "protein_name": "RING-type E3 ubiquitin transferase", "gene_name": "Trim33", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAENKGGGEAESGGGGSGSAPVTAGAAGPTAQEAEPPLAAVLVEEEEEEGGRAGAEGGAAGPDDGGVAAASSSSAPAASVPAASVGSAVPGGAASTPAPAPVPVPVPVPVPAPAPAPAPAPAPAPGPSSGPPPGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIPGGSNGDVQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCIEAHQRVKFTKDHLIRKKEDVSESVGTSGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIASGSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRLQQPPAPVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGIPRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSAHNPINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQLEDAGSSSLDNLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKSAHSFKSDQVKVKQEPGTEEEICSFSGAVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDTLTSLENHVKTEPADISESCKQSGLSSLVNGKSPIRNLMHRSARIGGDGNSKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNMQHSKKGKTAQGLSPVDQRKCERLLLYLYCHELSIEFQEPVPVSIPNYYKIIKKPMDLSTVKKKLQKKHSQHYQIPDDFVADVRLIFKNCERFNEMMKVVQVYADTQEINLKADSEVAQAGKAVALYFEDKLSEIYSDRTFAPLPEFEQEEDDGEVTEDSDEDFIQPRRKRLKSDERPVHIK", "length": 1144 }, "evidence": [ { "id": "45226341", "url": "http://www.informatics.jax.org/homology/45226341", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q99PP7-1", "protein_name": "E3 ubiquitin-protein ligase TRIM33", "gene_name": "Trim33", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAENKGGGEAESGGGGSGSAPVTAGAAGPTAQEAEPPLAAVLVEEEEEEGGRAGAEGGAAGPDDGGVAAASSSSAPAASVPAASVGSAVPGGAASTPAPAAAPAPAPAPAPAPAPAPAPAPAPGSSSGPPLGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIPGGSNGDVQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCIEAHQRVKFTKDHLIRKKEDVSESVGTSGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIASGSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRLQQPPAPIPTTTATTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGIPRHSAPQYSMMQPHLQRQHSNPGHAGPFPVVSAHNPINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQLEDAGSSSLDNLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKSAHSFKSDQVKVKQEPGTEEEICSFSGAVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDTLTGLENHVKTEPTDISESCKQSGLSNLVNGKSPIRNLMHRSARIGGDGNSKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNMQHSKKGKTAQGLSPVDQRKCERLLLYLYCHELSIEFQEPVPVSIPNYYKIIKKPMDLSTVKKKLQKKHSQHYQIPDDFVADVRLIFKNCERFNEMMKVVQVYADTQEINLKGDSEVAKAGKAVALYFEDKLSEIYSDRTFTPLPEFEQDEDDGEVTEDSDEDFIQPRRKRLKSDERPVHIK", "length": 1142 }, "evidence": [ { "id": "45226341", "url": "http://www.informatics.jax.org/homology/45226341", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q9UPN9", "url": "https://www.uniprot.org/uniprot/Q9UPN9" } ], "pmid": "" }, { "name": "co-SMAD binding", "id": "GO:0070410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070410", "evidence": [ { "database": "UniProtKB", "id": "Q9UPN9", "url": "https://www.uniprot.org/uniprot/Q9UPN9" } ], "pmid": "" }, { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q9UPN9", "url": "https://www.uniprot.org/uniprot/Q9UPN9" } ], "pmid": "" }, { "name": "ubiquitin-protein transferase activity", "id": "GO:0004842", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004842", "evidence": [ { "database": "UniProtKB", "id": "Q9UPN9", "url": "https://www.uniprot.org/uniprot/Q9UPN9" } ], "pmid": "" }, { "name": "R-SMAD binding", "id": "GO:0070412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070412", "evidence": [ { "database": "UniProtKB", "id": "Q9UPN9", "url": "https://www.uniprot.org/uniprot/Q9UPN9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "regulation of transforming growth factor beta receptor signaling pathway", "id": "GO:0017015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017015", "evidence": [ { "database": "UniProtKB", "id": "Q9UPN9", "url": "https://www.uniprot.org/uniprot/Q9UPN9" } ], "pmid": "" }, { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "Q9UPN9", "url": "https://www.uniprot.org/uniprot/Q9UPN9" } ], "pmid": "" }, { "name": "negative regulation of DNA-templated transcription", "id": "GO:0045892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "evidence": [ { "database": "UniProtKB", "id": "Q9UPN9", "url": "https://www.uniprot.org/uniprot/Q9UPN9" } ], "pmid": "" }, { "name": "negative regulation of BMP signaling pathway", "id": "GO:0030514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030514", "evidence": [ { "database": "UniProtKB", "id": "Q9UPN9", "url": "https://www.uniprot.org/uniprot/Q9UPN9" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "Q9UPN9", "url": "https://www.uniprot.org/uniprot/Q9UPN9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q9UPN9", "url": "https://www.uniprot.org/uniprot/Q9UPN9" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q9UPN9", "url": "https://www.uniprot.org/uniprot/Q9UPN9" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 223, "end_pos": 225, "annotation": "n_glycosylation_sequon" }, { "start_pos": 352, "end_pos": 354, "annotation": "n_glycosylation_sequon" }, { "start_pos": 386, "end_pos": 388, "annotation": "n_glycosylation_sequon" }, { "start_pos": 414, "end_pos": 416, "annotation": "n_glycosylation_sequon" }, { "start_pos": 637, "end_pos": 639, "annotation": "n_glycosylation_sequon" }, { "start_pos": 846, "end_pos": 848, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Sumoylated with SUMO1.", "evidence": [ { "database": "UniProtKB", "id": "Q9UPN9", "url": "https://www.uniprot.org/uniprot/Q9UPN9" }, { "database": "PubMed", "id": "Q99PP7", "url": "https://glygen.org/publication/PubMed/Q99PP7" } ] } ], "interactions": [], "reactions": [ { "id": "R-HSA-480378", "name": "Expression of Goosecoid (GSC) in the primitive streak", "equation": "", "summary": "The Goosecoid (GSC) gene is transcribed to yield mRNA and the mRNA is translated to yield GSC protein. Expression of GSC is first observed in the region of the epiblast where the primitive streak forms (inferred from the mouse homolog). Expression then becomes restricted to the anterior primitive streak and the anterior midline mesoderm. Phosphorylated SMAD2 and SMAD3 in complexes with SMAD4 and TRIM33 activate transcription of GSC (inferred from mouse homologs). Beta-catenin (CTNNB1) also binds the GSC promoter and interacts with SMAD2 and SMAD3 to enhance transcription of GSC (Funa et al. 2015). GSC can bind its own promoter and downregulate expression (Danilov et al. 1998). POU5F1 (OCT4), SOX2, and NANOG bind the promoter of the GSC gene (Boyer et al. 2005), OCT4 and SOX2 repress transcription of GSC, and NANOG activates transcription of GSC in human embryonic stem cells (Babaie et al. 2007, Teo et al. 2011).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [ "R-HSA-452569" ], "enzyme_list": [ "Q9UPN9-1" ], "evidence": [ { "id": "R-HSA-480378", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-480378" } ] }, { "id": "R-HSA-870449", "name": "TRIM33 monoubiquitinates SMAD4", "equation": "", "summary": "TRIM33 (also known as Ecto, Ectodermin or Tif1-gamma) monoubiquitinates nuclear SMAD4 on lysine residue K519. This leads to disruption of heterotrimeric complexes composed of SMAD4 and two phosphorylated R-SMADs (SMAD2 and/or SMAD3). TRIM33 inhibits SMAD activity without affecting steady state levels of SMAD4 (Dupont et al. 2009, Dupont et al. 2005).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9UPN9-1" ], "evidence": [ { "id": "R-HSA-870449", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-870449" } ] }, { "id": "R-HSA-870538", "name": "TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus", "equation": "", "summary": "E3 ubiquitin protein ligase TRIM33 (also known as Ecto, Ectodermin or Tif1-gamma) binds to the SMAD heterotrimer, composed of SMAD4 and two phosphorylated R-SMADs (SMAD2 and/or SMAD3), in the nucleus (Dupont et al. 2009, Dupont et al. 2005, He et al. 2006).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9UPN9-1" ], "evidence": [ { "id": "R-HSA-870538", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-870538" } ] }, { "id": "R-HSA-9756724", "name": "p-2S-SMAD2,3:TRIM33, p-2S-SMAD2,3:SMAD4, CTNNB1, EOMES, and TBPL2 bind FOXH1:MIXL1 gene", "equation": "", "summary": "In differentiating human embryonic stem cells (ESCs), beta-catenin (CTNNB1):LEF1, SMAD2,3, and OCT4 bind to an upstream enhancer region (Estar\u00e1s 2015, Funa 2015) and both SMAD2 and FOXH1 bind to the immediate promoter region of MIXL1 to mediate MIXL1 expression driven by WNT and NODAL signaling. CTNNB1 from WNT signaling binds the promoter and interacts directly with SMAD proteins (Funa et al. 2015). Knockdown of CTNNB1, SMAD2, or OCT4 results in reduced MIXL1 expression (Funa et al. 2015). EOMES binds the enhancer and promoter regions of the MIXL1 gene and is important for transcriptional activation (Teo et al. 2011, and inferred from mouse embryos). The basal transcription factor TBPL2 (TRF3) also binds the promoter of the MIXL1 gene (Liang et al. 2020). NODAL causes phosphorylation of SMAD2 and SMAD3 which then complex with SMAD4 and transit to the nucleus. Phosphorylated SMAD2 and SMAD3 are also present in complexes with TRIM33 in the nucleus (inferred from mouse homologs). SMAD2,3:TRIM33 complexes bind methylated histone H3 lysine-9 and acetylated histone H3 lysine-18 to open chromatin at the MIXL1 promoter (inferred from mouse homologs). SMAD2,3:SMAD4 also binds the MIXL1 promoter (inferred from mouse homologs).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9UPN9-1" ], "evidence": [ { "id": "R-HSA-9756724", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9756724" } ] }, { "id": "R-HSA-9756948", "name": "p-2S-SMAD2,3:SMAD4, p-2S-SMAD2,3:TRIM33, CTNNB1, EOMES, and TBPL2 bind FOXH1:SMAD3:GSC gene", "equation": "", "summary": "In mesendoderm progenitors differentiated from embryonic stem cells in vitro, FOXH1 and SMAD3 are pre-bound to the GSC gene (inferred from mouse homologs). The same situation is inferred to occur in cells of the primitive streak. NODAL signaling causes phosphorylation of SMAD2 and SMAD3, which transit to the nucleus with SMAD4. SMAD2 interacts with SMAD3 at the promoter of the GSC gene (Martin-Malpartida et al. 2017, Funa et al. 2015, and inferred from mouse homologs). After activation by NODAL, phosphorylated SMAD2 and SMAD3 are also complexed with TRIM33 in the nucleus and the p-2S-SMAD2,3:TRIM33 complex binds methylated histone H3 lysine-9 and acetylated histone H3 lysine-18 at the promoter of GSC, which may open chromatin at the promoter (inferred from mouse homologs). Beta-catenin (CTNNB1) activated by Wnt signaling also binds the GSC gene and interacts directly with SMADs to yield full activation of GSC (Funa et al. 2015). EOMES also binds regulatory regions of the GSC gene and is crucial for its activation (Teo et al. 2011, and inferred from mouse homologs). The basal transcription factor TBPL2 (TRF3) also binds the promoter of the GSC gene (Liang et al. 2020).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9UPN9-1" ], "evidence": [ { "id": "R-HSA-9756948", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9756948" } ] }, { "id": "R-HSA-9758501", "name": "Expression of MIXL1 in the primitive streak", "equation": "", "summary": "During gastrulation, MIXL1 is expressed throughout the primitive streak and the nascent mesoderm, but then becomes localized to the anterior and posterior ends of the streak (inferred from the mouse homolog in mouse embryos, inferred from the non-human primate Macaca fascicularis in Nakamura et al. 2016, Sasaki et al. 2016). Transcription of MIXL1 is activated by NODAL via SMAD2,3, EOMES, and by WNT via beta-catenin (CTNNB1) (Teo et al. 2011, Funa et al. 2015, and inferred from mouse homologs).", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-HSA-9756734" ], "output_participant_list": [ "R-HSA-9758510" ], "enzyme_list": [ "Q9UPN9-1" ], "evidence": [ { "id": "R-HSA-9758501", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9758501" } ] } ], "reaction_participants": [ { "participant_id": "R-HSA-452569", "participant_name": "GSC [nucleoplasm]", "crossref": [ { "id": "ENST00000238558", "database": "Ensembl", "url": "" }, { "id": "ENSG00000133937-GSC", "database": "HPA", "url": "" }, { "id": "P56915", "database": "PRO", "url": "" }, { "id": "ENSG00000133937", "database": "OpenTargets", "url": "" }, { "id": "ENSG00000133937", "database": "Ensembl", "url": "" }, { "id": "NP_776248.1", "database": "RefSeq", "url": "" }, { "id": "P56915", "database": "UniProt", "url": "" }, { "id": "P56915", "database": "GeneCards", "url": "" }, { "id": "2DMU", "database": "PDB", "url": "" }, { "id": "P56915", "database": "Pharos - Targets", "url": "" }, { "id": "ENSP00000238558", "database": "Ensembl", "url": "" } ] }, { "participant_id": "R-HSA-9756734", "participant_name": "MIXL1 gene [nucleoplasm]", "crossref": [ { "id": "ENSG00000185155", "database": "ENSEMBL", "url": "" } ] }, { "participant_id": "R-HSA-9758510", "participant_name": "MIXL1 [nucleoplasm]", "crossref": [ { "id": "Q9H2W2", "database": "UniProt", "url": "" }, { "id": "ENSG00000185155", "database": "Ensembl", "url": "" }, { "id": "ENST00000542034", "database": "Ensembl", "url": "" }, { "id": "ENSG00000185155-MIXL1", "database": "HPA", "url": "" }, { "id": "ENSP00000355775", "database": "Ensembl", "url": "" }, { "id": "Q9H2W2", "database": "Pharos - Targets", "url": "" }, { "id": "ENSG00000185155", "database": "OpenTargets", "url": "" }, { "id": "NP_114150.1", "database": "RefSeq", "url": "" }, { "id": "Q9H2W2", "database": "PRO", "url": "" }, { "id": "NP_001269331.1", "database": "RefSeq", "url": "" }, { "id": "ENST00000366810", "database": "Ensembl", "url": "" }, { "id": "ENSP00000442439", "database": "Ensembl", "url": "" }, { "id": "Q9H2W2", "database": "GeneCards", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "Q9UPN9", "gene_name": "TRIM33", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9UPN9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UPN9" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9UPN9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UPN9" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 4 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { 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