{
    "uniprot_canonical_ac": "Q9R1A3-1",
    "uniprot_ac": "Q9R1A3",
    "uniprot_id": "NET3_MOUSE",
    "mass": {
        "chemical_mass": 62023.0,
        "monoisotopic_mass": 62023.0
    },
    "refseq": {
        "ac": "NP_035077",
        "name": "netrin-3 precursor",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035077"
    },
    "gene_names": [
        {
            "name": "Ntn3",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q9R1A3",
            "id": "Q9R1A3"
        },
        {
            "name": "Ntn2l",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035077",
            "id": "NP_035077"
        },
        {
            "name": "Ntn2l",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q9R1A3",
            "id": "Q9R1A3"
        },
        {
            "name": "Ntn3",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035077",
            "id": "NP_035077"
        }
    ],
    "protein_names": [
        {
            "name": "Netrin-3",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q9R1A3"
        },
        {
            "name": "Netrin-2-like protein",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q9R1A3"
        },
        {
            "name": "netrin-2-like protein",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035077",
            "id": "NP_035077"
        },
        {
            "name": "netrin-3 precursor",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035077",
            "id": "NP_035077"
        }
    ],
    "function": [
        {
            "annotation": "Netrin-3 Suppresses Diabetic Neuropathic Pain by Gating the Intra-epidermal Sprouting of Sensory Axons.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_035077",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035077"
                },
                {
                    "database": "PubMed",
                    "id": "36587114",
                    "url": "https://glygen.org/publication/PubMed/36587114"
                }
            ]
        },
        {
            "annotation": "Netrin-3 is expressed by the fetal mucosal epithelium and pancreas.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_035077",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035077"
                },
                {
                    "database": "PubMed",
                    "id": "12798294",
                    "url": "https://glygen.org/publication/PubMed/12798294"
                }
            ]
        },
        {
            "annotation": "Netrins control guidance of CNS commissural axons and peripheral motor axons.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9R1A3",
                    "url": "https://www.uniprot.org/uniprot/Q9R1A3#function"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [
        {
            "evidence": [
                {
                    "id": "rs3407547274",
                    "database": "dbSNP",
                    "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs3407547274"
                }
            ],
            "glycoeffect": [
                "n-glyco-sequon-gain",
                "o-glyco-site-loss"
            ],
            "start_pos": 414,
            "end_pos": 414,
            "sequence_org": "S",
            "sequence_mut": "N",
            "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (SRS->NRS).",
            "chr_id": "17",
            "chr_pos": "24426566",
            "ref_nt": "T",
            "alt_nt": "null",
            "minor_allelic_frequency": "",
            "site_lbl": "S414",
            "keywords": [
                "ebi",
                "germline"
            ]
        }
    ],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9R1A3",
                    "url": "https://www.uniprot.org/uniprot/Q9R1A3"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Ntn3",
            "url": "https://www.uniprot.org/uniprot/Q9R1A3",
            "locus": {
                "chromosome": "17",
                "start_pos": 24422822,
                "end_pos": 24428505,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000117406",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000117406"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000117406",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000117406",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd00055",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00055",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "cd03579",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03579",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "18209",
            "url": "https://www.ncbi.nlm.nih.gov/gene/18209",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "GPDB0007720",
            "url": "https://acgg.asia/db/gpdb/symbol/GPDB0007720",
            "database": "GlycoProtDB",
            "categories": [
                "Glycoproteomics"
            ]
        },
        {
            "id": "IPR001134",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001134",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR002049",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR002049",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR008211",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR008211",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR008993",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR008993",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR018933",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR018933",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:18209",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:18209",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "1341188",
            "url": "http://www.informatics.jax.org/marker/MGI:1341188",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "SHCRPAR",
            "url": "https://omabrowser.org/oma/group/SHCRPAR/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "2916807at2759",
            "url": "http://www.orthodb.org/?query=2916807at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR10574",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10574",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR10574:SF292",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10574:SF292",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00053",
            "url": "http://pfam.xfam.org/family/PF00053",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00055",
            "url": "http://pfam.xfam.org/family/PF00055",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF01759",
            "url": "http://pfam.xfam.org/family/PF01759",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q9R1A3",
            "url": "http://purl.obolibrary.org/obo/PR_Q9R1A3",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_035077",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035077",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A3Q4EI17",
            "url": "https://www.uniprot.org/uniprot/A0A3Q4EI17",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A3Q4EI17-1",
            "url": "https://www.uniprot.org/uniprot/A0A3Q4EI17-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q9R1A3",
            "url": "https://www.uniprot.org/uniprot/Q9R1A3",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q9R1A3-1",
            "url": "https://www.uniprot.org/uniprot/Q9R1A3-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MPTWLWGLLLTAGTLSAALSPGLPASADPCYDEAREPRSCIPGLVNAALGREVLASSTCGRSANRVCDSSDPQRAHSADLLTSAPGTASPLCWRSDLLQQAPFNVTLTVPLGKAFELVFVSLRFCSAPPTSVALLKSQDHGRSWVPLGFFSSSCTLDYGRLPAPADGPSGPGPEALCFPAPQAQPDGGGLLAFSVQDGSPQGLDLDNSPVLQDWVTATDIRIVLTRPAIQGDTRDGGVTVPYSYSATELQVGGRCKCNGHASRCLLDTHGHLVCDCQHGTEGPDCSRCKPFYCDRPWQRATGQEAHACLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRVLSDRRACRACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPGFQQSRSPVAPCVKTPVPGPTEESSPVEPQDCESHCRPARGSYRISLKKFCRKDYAVQVAVGARGEARGSWTRFPVAVLAVFRSGEERARRGSSALWVPTLDAACGCPRLLPGRRYLLLGGGPGAAAGSTAGRGQGLSAARGSLVLPWRDAWTRRLRRLQRRERRGRCGTA",
        "length": 580,
        "header": "sp|Q9R1A3-1|NET3_MOUSE Isoform 1 of Netrin-3  OS=Mus musculus OX=10090 GN=Ntn3 PE=2 SV=1 CANONICAL=Q9R1A3-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A3Q4EI17-1",
            "url": "",
            "sequence": {
                "sequence": "MPTWLWGLLLTAGTLSAALSPGLPASADPCYDEAREPRSCIPGLVNAALGREVLASSTCGRSANRVCDSSDPQRAHSADLLTSAPGTASPLCWRSDLLQQAPFNVTLTVPLGKAFELVFVSLRFCSAPPTSVALLKSQDHGRSWVPLGFFSSSCTLDYGRLPAPADGPSGPGPEALCFPAPQAQPDGGGLLAFSVQDGSPQGLDLDNSPVLQDWLAPATAMREDAASTWSSTDCPAAAVGACASTAGTIQLVVTATTAGRASIVIQAVS",
                "length": 269,
                "header": "tr|A0A3Q4EI17-1|A0A3Q4EI17_MOUSE Computationally mapped isoform of Netrin 3  OS=Mus musculus OX=10090 GN=Ntn3 PE=4 SV=1 CANONICAL=Q9R1A3-1"
            },
            "locus": {
                "chromosome": "17",
                "start_pos": 24427960,
                "end_pos": 24426797,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000234420.2",
                        "url": "https://www.ensembl.org/id/ENSMUST00000234420.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000157203.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000157203.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q9R1A3-1",
            "url": "",
            "sequence": {
                "sequence": "MPTWLWGLLLTAGTLSAALSPGLPASADPCYDEAREPRSCIPGLVNAALGREVLASSTCGRSANRVCDSSDPQRAHSADLLTSAPGTASPLCWRSDLLQQAPFNVTLTVPLGKAFELVFVSLRFCSAPPTSVALLKSQDHGRSWVPLGFFSSSCTLDYGRLPAPADGPSGPGPEALCFPAPQAQPDGGGLLAFSVQDGSPQGLDLDNSPVLQDWVTATDIRIVLTRPAIQGDTRDGGVTVPYSYSATELQVGGRCKCNGHASRCLLDTHGHLVCDCQHGTEGPDCSRCKPFYCDRPWQRATGQEAHACLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRVLSDRRACRACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPGFQQSRSPVAPCVKTPVPGPTEESSPVEPQDCESHCRPARGSYRISLKKFCRKDYAVQVAVGARGEARGSWTRFPVAVLAVFRSGEERARRGSSALWVPTLDAACGCPRLLPGRRYLLLGGGPGAAAGSTAGRGQGLSAARGSLVLPWRDAWTRRLRRLQRRERRGRCGTA",
                "length": 580,
                "header": "sp|Q9R1A3-1|NET3_MOUSE Isoform 1 of Netrin-3  OS=Mus musculus OX=10090 GN=Ntn3 PE=2 SV=1 CANONICAL=Q9R1A3-1"
            },
            "locus": {
                "chromosome": "17",
                "start_pos": 24427960,
                "end_pos": 24425575,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000024931",
                        "url": "https://www.ensembl.org/id/ENSMUST00000024931"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000024931",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000024931"
                    }
                ]
            }
        }
    ],
    "glycosylation": [
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 104,
            "start_aa": "Asn",
            "end_pos": 104,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn104",
            "evidence": [
                {
                    "id": "Q9R1A3",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/Q9R1A3#ptm_processing"
                }
            ]
        },
        {
            "glytoucan_ac": "",
            "type": "N-linked",
            "subtype": "",
            "site_category": "predicted",
            "site_seq": "N",
            "relation": "attached",
            "comment": "N-linked (GlcNAc...) asparagine",
            "start_pos": 387,
            "start_aa": "Asn",
            "end_pos": 387,
            "end_aa": "Asn",
            "residue": "Asn",
            "site_lbl": "Asn387",
            "evidence": [
                {
                    "id": "Q9R1A3",
                    "database": "UniProtKB",
                    "url": "https://www.uniprot.org/uniprot/Q9R1A3#ptm_processing"
                }
            ]
        }
    ],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [
        "glycoprotein",
        "glycoprotein_predicted"
    ],
    "publication": [
        {
            "title": "Netrin-3, a mouse homolog of human NTN2L, is highly expressed in sensory ganglia and shows differential binding to netrin receptors.",
            "journal": "J. Neurosci.",
            "date": "1999",
            "authors": "Tessier-Lavigne M., Wang H., Copeland N.G., Gilbert D.J., Jenkins N.A.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9R1A3",
                    "url": "https://www.uniprot.org/uniprot/Q9R1A3"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "10366627",
                    "url": "https://glygen.org/publication/PubMed/10366627"
                }
            ]
        },
        {
            "title": "Divergent properties of mouse netrins.",
            "journal": "Mech. Dev.",
            "date": "1999",
            "authors": "PuschelPuschel AW",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9R1A3",
                    "url": "https://www.uniprot.org/uniprot/Q9R1A3"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "10381568",
                    "url": "https://glygen.org/publication/PubMed/10381568"
                }
            ]
        },
        {
            "title": "Netrin-3 protein is localized to the axons of motor, sensory, and sympathetic neurons.",
            "journal": "Mech. Dev.",
            "date": "2001",
            "authors": "Seaman C., Cooper H.M.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9R1A3",
                    "url": "https://www.uniprot.org/uniprot/Q9R1A3"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "11231084",
                    "url": "https://glygen.org/publication/PubMed/11231084"
                }
            ]
        },
        {
            "title": "Netrins and DCC in the guidance of migrating neural crest-derived cells in the developing bowel and pancreas.",
            "journal": "Developmental biology",
            "date": "2003",
            "authors": "Jiang Y, Liu MT, Gershon MD",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_035077",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035077"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "12798294",
                    "url": "https://glygen.org/publication/PubMed/12798294"
                }
            ]
        },
        {
            "title": "Netrin-3 Suppresses Diabetic Neuropathic Pain by Gating the Intra-epidermal Sprouting of Sensory Axons.",
            "journal": "Neuroscience bulletin",
            "date": "2023-05",
            "authors": "Pan Weiping, Huang Xueyin, Yu Zikai, Ding Qiongqiong, Xia Liping, Hua Jianfeng, Gu Bokai, Xiong Qisong, Yu Hualin, Wang Junbo, Xu Zhenzhong, Zeng Linghui, Bai Ge, Liu Huaqing",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_035077",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035077"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "36587114",
                    "url": "https://glygen.org/publication/PubMed/36587114"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:18209",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:18209",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "G3V6X3-1",
            "protein_name": "Netrin 3",
            "gene_name": "Ntn3",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MPTWPWGLLLTAGTLSAALSPGLPASADPCYDEAREPRCCTPGLVNAALGREVLASSTCGRPANHVCDPSDPQRAHSADLLTSAPGTASPLCWRSDVLQRAPFNVTLTVPLGKAFELVFVSLRFCSAPPTSVALLKSQDHGRSWVPLGFFSSSCSLDYGRLPAPADGPAGPGPEALCFPAPQAQPDGGGLLAFSVQDGSPQGLDLDNSPVLQDWVTATDIRIVLTRPAIQGDTRDGGVTVPYSYSATELQVGGRCKCNGHSSRCLMDTHGHLVCDCQHGTEGPDCSRCKPFYCDRPWQRATGQEAHACLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRVLSDRRACRACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPGFQQSRSPVAPCVKTPVPGPTEESSPVEPQDCESHCRPARGSYRISLKKFCRKDYAVQVAVGARGEARGAWTRFPVAVLAVFRSGEERARRGSSALWVPTLDAACGCPRLQPGRRYLLLGDGPGAAAGSPAGRGPGLSAARGSLVLPWRDAWTRRLRRLQRRERRGRCGTA",
                "length": 580
            },
            "evidence": [
                {
                    "id": "45227427",
                    "url": "http://www.informatics.jax.org/homology/45227427",
                    "database": "MGI"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "O00634-1",
            "protein_name": "Netrin-3",
            "gene_name": "NTN3",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MPGWPWGLLLTAGTLFAALSPGPPAPADPCHDEGGAPRGCVPGLVNAALGREVLASSTCGRPATRACDASDPRRAHSPALLTSPGGTASPLCWRSESLPRAPLNVTLTVPLGKAFELVFVSLRFCSAPPASVALLKSQDHGRSWAPLGFFSSHCDLDYGRLPAPANGPAGPGPEALCFPAPLAQPDGSGLLAFSMQDSSPPGLDLDSSPVLQDWVTATDVRVVLTRPSTAGDPRDMEAVVPYSYAATDLQVGGRCKCNGHASRCLLDTQGHLICDCRHGTEGPDCGRCKPFYCDRPWQRATARESHACLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPGFQQSRSPVAPCVKTPIPGPTEDSSPVQPQDCDSHCKPARGSYRISLKKFCKKDYAVQVAVGARGEARGAWTRFPVAVLAVFRSGEERARRGSSALWVPAGDAACGCPRLLPGRRYLLLGGGPGAAAGGAGGRGPGLIAARGSLVLPWRDAWTRRLRRLQRRERRGRCSAA",
                "length": 580
            },
            "evidence": [
                {
                    "id": "45227427",
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