{ "uniprot_canonical_ac": "Q9QZP2-1", "uniprot_ac": "Q9QZP2", "uniprot_id": "PRDM4_RAT", "mass": { "chemical_mass": 87392.0, "monoisotopic_mass": 87392.0 }, "refseq": { "ac": "NP_579846", "name": "PR domain zinc finger protein 4", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579846" }, "gene_names": [ { "name": "Prdm4", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q9QZP2", "id": "Q9QZP2" }, { "name": "Prdm4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006241222", "id": "XP_006241222" }, { "name": "SC-1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006241222", "id": "XP_006241222" } ], "protein_names": [ { "name": "PR domain zinc finger protein 4", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q9QZP2" }, { "name": "2.1.1.-", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9QZP2" }, { "name": "PR domain zinc finger protein 4 isoform X1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006241222", "id": "XP_006241222" }, { "name": "PR domain zinc finger protein 4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579846", "id": "NP_579846" }, { "name": "PR domain-containing protein 4; PR domain containing 4; PR domain 4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579846", "id": "NP_579846" }, { "name": "PR domain-containing protein 4", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9QZP2" } ], "function": [ { "annotation": "May function as a transcription factor involved in cell differentiation.", "evidence": [ { "database": "UniProtKB", "id": "Q9QZP2", "url": "https://www.uniprot.org/uniprot/Q9QZP2#function" } ] }, { "annotation": "SC1 and PRMT5 are components of an epigenetic regulatory complex that maintains the 'stem-like' cellular state of the neural stem cells.", "evidence": [ { "database": "RefSeq", "id": "NP_579846", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579846" }, { "database": "PubMed", "id": "23048031", "url": "https://glygen.org/publication/PubMed/23048031" } ] }, { "annotation": "We investigated the potential mechanism of nuclear shuttling of PRDM4 via the importin alpha/beta-mediated pathway and find that PRDM4 nuclear targeting is independent of alpha/beta-mediated nuclear import.", "evidence": [ { "database": "RefSeq", "id": "NP_579846", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579846" }, { "database": "PubMed", "id": "27125459", "url": "https://glygen.org/publication/PubMed/27125459" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "Q9QZP2", "url": "https://www.uniprot.org/uniprot/Q9QZP2" } ], "common_name": "Rat" } ], "gene": [ { "name": "Prdm4", "url": "https://www.uniprot.org/uniprot/Q9QZP2", "locus": { "chromosome": "7", "start_pos": 17980489, "end_pos": 17954019, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000004962", "url": "https://www.ensembl.org/id/ENSRNOG00000004962" } ] } } ], "crossref": [ { "id": "ENSRNOG00000004962", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000004962", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd19189", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19189", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "170820", "url": "https://www.ncbi.nlm.nih.gov/gene/170820", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001214", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001214", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013087", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017124", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017124", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036236", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041493", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041493", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044404", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044404", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046341", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046341", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:170820", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:170820", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QTGPHEL", "url": "https://omabrowser.org/oma/group/QTGPHEL/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5404083at2759", "url": "http://www.orthodb.org/?query=5404083at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16515", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16515", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16515:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16515:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00096", "url": "http://pfam.xfam.org/family/PF00096", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF18445", "url": "http://pfam.xfam.org/family/PF18445", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q9QZP2", "url": "http://purl.obolibrary.org/obo/PR_Q9QZP2", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_579846", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579846", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "619929", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=619929", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A8I6AA47", "url": "https://www.uniprot.org/uniprot/A0A8I6AA47", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6AA47-1", "url": "https://www.uniprot.org/uniprot/A0A8I6AA47-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1LPR7", "url": "https://www.uniprot.org/uniprot/F1LPR7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F1LPR7-1", "url": "https://www.uniprot.org/uniprot/F1LPR7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9QZP2", "url": "https://www.uniprot.org/uniprot/Q9QZP2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9QZP2-1", "url": "https://www.uniprot.org/uniprot/Q9QZP2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNDMNLSPVGMEQLSSSSVSNALPVSGSHLGLAASPSHSAIPAPGLPVAIPNLGPSLSSLPSALSLMLPMGIGDRGVMCGLPERNYTLPPPPYPHLESSYFRTILPGILSYLADRPPPQYIHPNSINVDGNTALSITNNPSALDPYQANGNVGLELGIVSIDSRSVNTHGAQSLHPNDGHEVALDTTITMENVSRVTSPISTDGMAEELTMDGVTGEHSQIPNGSRSHEPLSVDSVSNNLTADTVGHGGVIPIHGNGLELPVVMETDHIANRVNGISDSVLSDSIHTVAMSTNSVSVALSTSHNFASLESVSLQEVGLSLEPVAVSSITQEVAMGTGHVDVSSDSLSFVPSSLQMEDSNSNKENMATLFTIWCTLCDRAYPSDCPDHGPVTFVPDTPIESRARLSLPKQLVLRQSIVGTDVGVWTAETIPVRTCFGPLIGQQSHSMEVAEWTDKAVSHVWKIYHNGVLEFCIITTDENECNWMMFVRKARNREEQNLVAYPHDGKIYFCTSQDIPPENELLFYYSRDYAQQIGVPEHPDVHLCNCGKECSSYSEFKAHLTSHIHNHLPSQGHSSSHGPSHSKERKWKCSMCPQAFISPSKLHVHFMGHMGMKPHKCDFCSKAFSDPSNLRTHLKIHTGQKNYRCTLCDKSFTQKAHLESHMVIHTGEKNLKCDYCDKLFMRRQDLKQHVLIHTQERQIKCPKCDKLFLRTNHLKKHLNSHEGRRDYVCEKCTKAYLTKYHLTRHLKACKEPASSSSAQDDEDEDGDSGEDGLPGSMTTEGCRMSSAVYSADESLSAHK", "length": 798, "header": "sp|Q9QZP2-1|PRDM4_RAT Isoform 1 of PR domain zinc finger protein 4 OS=Rattus norvegicus OX=10116 GN=Prdm4 PE=2 SV=1 CANONICAL=Q9QZP2-1" }, "isoforms": [ { "isoform_ac": "A0A8I6AA47-1", "url": "", "sequence": { "sequence": "MNDMNLSPVGMEQLSSSSVSNALPVSGSHLGLAASPSHSAIPAPGLPVAIPNLGPSLSSLPSALSLMLPMGIGDRGVMCGLPERNYTLPPPPYPHLESSYFRTILPGILSYLADRPPPQYIHPNSINVDGNTALSITNNPSALDPYQANGNVGLELGIVSIDSRSVNTHGAQSLHPNDGHEVALDTTITMENVSRVTSPISTDGMAEELTMDGVTGEHSQIPNGSRSHEPLSVDSVSNNLTADTVGHGGVIPIHGNGLELPVVMETDHIANRVNGISDSVLSDSIHTVAMSTNSVSVALSTSHNLASLESVSLQEVGLSLEPVAVSSITQEVAMGTGHVDVSSDSLSFVPSSLQMEDSNSNKENMATLFTICKCASLFSSGNTFCVF", "length": 387, "header": "tr|A0A8I6AA47-1|PRDM4_RAT Computationally mapped isoform of PR domain zinc finger protein 4 OS=Rattus norvegicus OX=10116 GN=Prdm4 PE=2 SV=1 CANONICAL=Q9QZP2-1" }, "locus": { "chromosome": "7", "start_pos": 17964331, "end_pos": 17958666, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000100599.1", "url": "https://www.ensembl.org/id/ENSRNOT00000100599.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000090471.1", "url": "https://www.ensembl.org/id/ENSRNOP00000090471.1" } ] } }, { "isoform_ac": "F1LPR7-1", "url": "", "sequence": { "sequence": "MNDMNLSPVGMEQLSSSSVSNALPVSGSHLGLAASPSHSAIPAPGLPVAIPNLGPSLSSLPSALSLMLPMGIGDRGVMCGLPERNYTLPPPPYPHLESSYFRTILPGILSYLADRPPPQYIHPNSINVDGNTALSITNNPSALDPYQANGNVGLELGIVSIDSRSVNTHGAQSLHPNDGHEVALDTTITMENVSRVTSPISTDGMAEELTMDGVTGEHSQIPNGSRSHEPLSVDSVSNNLTADTVGHGGVIPIHGNGLELPVVMETDHIANRVNGISDSVLSDSIHTVAMSTNSVSVALSTSHNLASLESVSLQEVGLSLEPVAVSSITQEVAMGTGHVDVSSDSLSFVPSSLQMEDSNSNKENMATLFTIWCTLCDRAYPSDCPDHGPVTFVPDTPIESRARLSLPKQLVLRQSIVGTDVVGVLPLIGVWTAETIPVRTCFGPLIGQQSHSMEVAEWTDKAVSHVWKIYHNGVLEFCIITTDENECNWMMFVRKARNREEQNLVAYPHDGKIYFCTSQDIPPENELLFYYSRDYAQQIGVPEHPDVHLCNCGKECSSYSEFKAHLTSHIHNHLPSQGHSSSHGPSHSKERKWKCSMCPQAFISPSKLHVHFMGHMGMKPHKCDFCSKAFSDPSNLRTHLKIHTGQKNYRCTLCDKSFTQKAHLESHMVIHTGEKNLKCDYCDKLFMRRQDLKQHVLIHTQERQIKCPKCDKLFLRTNHLKKHLNSHEGRRDYVCEKCTKAYLTKYHLTRHLKACKEPASSSSAQDDEDEDGDSGEDGLPGSMTTEGCRMSSAVYSADESLSAHK", "length": 805, "header": "tr|F1LPR7-1|PRDM4_RAT Computationally mapped isoform of PR domain zinc finger protein 4 OS=Rattus norvegicus OX=10116 GN=Prdm4 PE=2 SV=3 CANONICAL=Q9QZP2-1" }, "locus": { "chromosome": "7", "start_pos": 17979279, "end_pos": 17958666, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000006886.7", "url": "https://www.ensembl.org/id/ENSRNOT00000006886.7" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000006886.6", "url": "https://www.ensembl.org/id/ENSRNOP00000006886.6" } ] } }, { "isoform_ac": "Q9QZP2-1", "url": "", "sequence": { "sequence": "MNDMNLSPVGMEQLSSSSVSNALPVSGSHLGLAASPSHSAIPAPGLPVAIPNLGPSLSSLPSALSLMLPMGIGDRGVMCGLPERNYTLPPPPYPHLESSYFRTILPGILSYLADRPPPQYIHPNSINVDGNTALSITNNPSALDPYQANGNVGLELGIVSIDSRSVNTHGAQSLHPNDGHEVALDTTITMENVSRVTSPISTDGMAEELTMDGVTGEHSQIPNGSRSHEPLSVDSVSNNLTADTVGHGGVIPIHGNGLELPVVMETDHIANRVNGISDSVLSDSIHTVAMSTNSVSVALSTSHNFASLESVSLQEVGLSLEPVAVSSITQEVAMGTGHVDVSSDSLSFVPSSLQMEDSNSNKENMATLFTIWCTLCDRAYPSDCPDHGPVTFVPDTPIESRARLSLPKQLVLRQSIVGTDVGVWTAETIPVRTCFGPLIGQQSHSMEVAEWTDKAVSHVWKIYHNGVLEFCIITTDENECNWMMFVRKARNREEQNLVAYPHDGKIYFCTSQDIPPENELLFYYSRDYAQQIGVPEHPDVHLCNCGKECSSYSEFKAHLTSHIHNHLPSQGHSSSHGPSHSKERKWKCSMCPQAFISPSKLHVHFMGHMGMKPHKCDFCSKAFSDPSNLRTHLKIHTGQKNYRCTLCDKSFTQKAHLESHMVIHTGEKNLKCDYCDKLFMRRQDLKQHVLIHTQERQIKCPKCDKLFLRTNHLKKHLNSHEGRRDYVCEKCTKAYLTKYHLTRHLKACKEPASSSSAQDDEDEDGDSGEDGLPGSMTTEGCRMSSAVYSADESLSAHK", "length": 798, "header": "sp|Q9QZP2-1|PRDM4_RAT Isoform 1 of PR domain zinc finger protein 4 OS=Rattus norvegicus OX=10116 GN=Prdm4 PE=2 SV=1 CANONICAL=Q9QZP2-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Identification of a zinc finger protein whose subcellular distribution is regulated by serum and nerve growth factor.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1999", "authors": "Chittka A, Chao MV", "evidence": [ { "database": "UniProtKB", "id": "Q9QZP2", "url": "https://www.uniprot.org/uniprot/Q9QZP2" } ], "reference": [ { "type": "PubMed", "id": "10485890", "url": "https://glygen.org/publication/PubMed/10485890" } ] }, { "title": "Transcription factor positive regulatory domain 4 (PRDM4) recruits protein arginine methyltransferase 5 (PRMT5) to mediate histone arginine methylation and control neural stem cell proliferation and differentiation.", "journal": "The Journal of biological chemistry", "date": "2012", "authors": "Chittka A, Nitarska J, Grazini U, Richardson WD", "evidence": [ { "database": "RefSeq", "id": "NP_579846", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579846" } ], "reference": [ { "type": "PubMed", "id": "23048031", "url": "https://glygen.org/publication/PubMed/23048031" } ] }, { "title": "Zinc fingers 1, 2, 5 and 6 of transcriptional regulator, PRDM4, are required for its nuclear localisation.", "journal": "Biochemical and biophysical research communications", "date": "2016", "authors": "Tunbak H, Georgiou C, Guan C, Richardson WD, Chittka A", "evidence": [ { "database": "RefSeq", "id": "NP_579846", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_579846" } ], "reference": [ { "type": "PubMed", "id": "27125459", "url": "https://glygen.org/publication/PubMed/27125459" } ] } ], "pathway": [ { "id": "rno:170820", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:170820", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q80V63-1", "protein_name": "PR domain zinc finger protein 4", "gene_name": "Prdm4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MNDMNLSPVGMEQLSSSSVSNALPVSGSHLGLAASPSHSAIPAPGLPVAIPNLGPSLSSLPSALSLMLPVGIGDRGVMCGLPERNYTLPPPPYPHLESSYFRTILPGILSYLADRPPPQYIHPNSINVDGNTALSITNNPSALDPYQANGNVGLELGIVSIDSRSVNTHGAQSLHPNDGHEVALDTTITMENVSRVTSPISTDGMAEELTMDGVTGEHPQIPNGSRSHEPLSVDSVSNSLTAEAVGHGGVIPIHGNGLELPVVMETDHIANRVNGMSDSTLSDSIHTVAMSTNSVSVALSTSHNLASLESVSLHEVGLSLEPVAVSSITQEVAMGTGHVDVSSDSLSFVPSSLQMEDSNSNKENMATLFTIWCTLCDRAYPSDCPDHGPVTFVPDTPIESRARLSLPKQLVLRQSIVGTDVVGVLPLIGVWTAETIPVRTCFGPLIGQQSHSLEVAEWTDKAVNHVWKIYHTGVLEFCIITTDENECNWMMFVRKARNREEQNLVAYPHDGKIYFCTSQDIPPESELLFYYSRNYAQQIGVPEHPDVHLCNCGKECSSYSEFKAHLTSHIHNHLPSQGHSSSHGPSHSKERKWKCSMCPQAFISPSKLHVHFMGHMGMKPHKCDFCSKAFSDPSNLRTHLKIHTGQKNYRCTLCDKSFTQKAHLESHMVIHTGEKNLKCDYCDKLFMRRQDLKQHVLIHTQERQIKCPKCDKLFLRTNHLKKHLNSHEGKRDYVCEKCTKAYLTKYHLTRHLKTCKEPSSSSSAQEEEDDESEEEDLADSMRTEDCRMGSAVYSTDESLSAHK", "length": 803 }, "evidence": [ { "id": "45227194", "url": "http://www.informatics.jax.org/homology/45227194", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9UKN5-1", "protein_name": "PR domain zinc finger protein 4", "gene_name": "PRDM4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MHHRMNEMNLSPVGMEQLTSSSVSNALPVSGSHLGLAASPTHSAIPAPGLPVAIPNLGPSLSSLPSALSLMLPMGIGDRGVMCGLPERNYTLPPPPYPHLESSYFRTILPGILSYLADRPPPQYIHPNSINVDGNTALSITNNPSALDPYQSNGNVGLEPGIVSIDSRSVNTHGAQSLHPSDGHEVALDTAITMENVSRVTSPISTDGMAEELTMDGVAGEHSQIPNGSRSHEPLSVDSVSNNLAADAVGHGGVIPMHGNGLELPVVMETDHIASRVNGMSDSALSDSIHTVAMSTNSVSVALSTSHNLASLESVSLHEVGLSLEPVAVSSITQEVAMGTGHVDVSSDSLSFVSPSLQMEDSNSNKENMATLFTIWCTLCDRAYPSDCPEHGPVTFVPDTPIESRARLSLPKQLVLRQSIVGAEVGVWTGETIPVRTCFGPLIGQQSHSMEVAEWTDKAVNHIWKIYHNGVLEFCIITTDENECNWMMFVRKARNREEQNLVAYPHDGKIFFCTSQDIPPENELLFYYSRDYAQQIGVPEHPDVHLCNCGKECNSYTEFKAHLTSHIHNHLPTQGHSGSHGPSHSKERKWKCSMCPQAFISPSKLHVHFMGHMGMKPHKCDFCSKAFSDPSNLRTHLKIHTGQKNYRCTLCDKSFTQKAHLESHMVIHTGEKNLKCDYCDKLFMRRQDLKQHVLIHTQERQIKCPKCDKLFLRTNHLKKHLNSHEGKRDYVCEKCTKAYLTKYHLTRHLKTCKGPTSSSSAPEEEEEDDSEEEDLADSVGTEDCRINSAVYSADESLSAHK", "length": 801 }, "evidence": [ { "id": "45227194", "url": "http://www.informatics.jax.org/homology/45227194", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q9QZP2", "url": "https://www.uniprot.org/uniprot/Q9QZP2" } ], "pmid": "" }, { "name": "histone methyltransferase complex", "id": "GO:0035097", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035097", "evidence": [ { "database": "UniProtKB", "id": "Q9QZP2", "url": "https://www.uniprot.org/uniprot/Q9QZP2" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q9QZP2", "url": "https://www.uniprot.org/uniprot/Q9QZP2" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q9QZP2", "url": "https://www.uniprot.org/uniprot/Q9QZP2" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q9QZP2", "url": "https://www.uniprot.org/uniprot/Q9QZP2" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 11, "go_terms": [ { "name": "transcription by RNA polymerase II", "id": "GO:0006366", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006366", "evidence": [ { "database": "UniProtKB", "id": "Q9QZP2", "url": "https://www.uniprot.org/uniprot/Q9QZP2" } ], "pmid": "" }, { "name": "methylation", "id": "GO:0032259", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032259", "evidence": [ { "database": "UniProtKB", "id": "Q9QZP2", "url": "https://www.uniprot.org/uniprot/Q9QZP2" } ], "pmid": "" }, { "name": "cellular response to nutrient", "id": "GO:0031670", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031670", "evidence": [ { "database": "UniProtKB", "id": "Q9QZP2", "url": "https://www.uniprot.org/uniprot/Q9QZP2" } ], "pmid": "" }, { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "Q9QZP2", "url": "https://www.uniprot.org/uniprot/Q9QZP2" } ], "pmid": "" }, { "name": "negative regulation of gene expression", "id": "GO:0010629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010629", "evidence": [ { "database": "UniProtKB", "id": "Q9QZP2", "url": "https://www.uniprot.org/uniprot/Q9QZP2" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "Q9QZP2", "url": "https://www.uniprot.org/uniprot/Q9QZP2" } ], "pmid": "" }, { "name": "cellular response to growth factor stimulus", "id": "GO:0071363", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071363", "evidence": [ { "database": "UniProtKB", "id": "Q9QZP2", "url": "https://www.uniprot.org/uniprot/Q9QZP2" } ], "pmid": "" }, { "name": "negative regulation of cell growth", "id": "GO:0030308", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030308", "evidence": [ { "database": "UniProtKB", "id": "Q9QZP2", "url": "https://www.uniprot.org/uniprot/Q9QZP2" } ], "pmid": "" }, { "name": "cell fate commitment", "id": "GO:0045165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045165", "evidence": [ { "database": "UniProtKB", "id": "Q9QZP2", "url": "https://www.uniprot.org/uniprot/Q9QZP2" } ], "pmid": "" }, { "name": "regulation of neural precursor cell proliferation", "id": "GO:2000177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000177", "evidence": [ { "database": "UniProtKB", "id": "Q9QZP2", "url": "https://www.uniprot.org/uniprot/Q9QZP2" } ], "pmid": "" }, { "name": "regulation of stem cell differentiation", "id": "GO:2000736", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000736", "evidence": [ { "database": "UniProtKB", "id": "Q9QZP2", "url": "https://www.uniprot.org/uniprot/Q9QZP2" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 8, "go_terms": [ { "name": "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "id": "GO:0000978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000978", "evidence": [ { "database": "UniProtKB", "id": "Q9QZP2", "url": "https://www.uniprot.org/uniprot/Q9QZP2" } ], "pmid": "" }, { "name": "methyltransferase activity", "id": "GO:0008168", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008168", "evidence": [ { "database": "UniProtKB", "id": "Q9QZP2", "url": "https://www.uniprot.org/uniprot/Q9QZP2" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "Q9QZP2", "url": "https://www.uniprot.org/uniprot/Q9QZP2" } ], "pmid": "" }, { "name": "histone methyltransferase binding", "id": "GO:1990226", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990226", "evidence": [ { "database": "UniProtKB", "id": "Q9QZP2", "url": "https://www.uniprot.org/uniprot/Q9QZP2" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q9QZP2", "url": "https://www.uniprot.org/uniprot/Q9QZP2" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "Q9QZP2", "url": "https://www.uniprot.org/uniprot/Q9QZP2" } ], "pmid": "" }, { "name": "death receptor binding", "id": "GO:0005123", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005123", "evidence": [ { "database": "UniProtKB", "id": "Q9QZP2", "url": "https://www.uniprot.org/uniprot/Q9QZP2" } ], "pmid": "" }, { "name": "sequence-specific double-stranded DNA binding", "id": "GO:1990837", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990837", "evidence": [ { "database": "UniProtKB", "id": "Q9QZP2", "url": "https://www.uniprot.org/uniprot/Q9QZP2" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 192, "end_pos": 194, "annotation": "n_glycosylation_sequon" }, { "start_pos": 223, "end_pos": 225, "annotation": "n_glycosylation_sequon" }, { "start_pos": 239, "end_pos": 241, "annotation": "n_glycosylation_sequon" }, { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" }, { "start_pos": 85, "end_pos": 87, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-RNO-194493", "name": "Prdm4 (Sc1) binds to p75NTR", "equation": "", "summary": "PRDM4, usually named SC1, for Schwann Cell factor 1, is a zinc finger protein that functions as a repressor of transcription. It is present in many tissues, and abundant in brain. It interacts with the NGF:p75NTR complex to signal cell cycle arrest. It is unclear whether it already forms a complex with p75NTR before NGF binding to p75.", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9QZP2-1" ], "evidence": [ { "id": "R-RNO-194493", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-194493" } ] }, { "id": "R-RNO-194578", "name": "Prdm4 translocates to the nucleus", "equation": "", "summary": "PRDM4 is found in the cytoplasm. Following binding of NGF to p75NTR, after 1 hour of NGF treatment, PRDM4 is redistributed from the cytoplasm to the nucleus. The relocalisation of PRDM4 appears to be specific for NGF, as it is not affected by BDNF or NT3.", "cellular_location": "nuclear envelope", "input_participant_list": [ "R-RNO-194573" ], "output_participant_list": [ "R-RNO-194536" ], "enzyme_list": [ "Q9QZP2-1" ], "evidence": [ { "id": "R-RNO-194578", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-194578" } ] }, { "id": "R-RNO-205010", "name": "Prdm4 inhibits cyclin E transcription", "equation": "", "summary": "Within the nucleus, PRDM4 is found in a complex with HDACs (histone deacetylases) 1, 2, and 3. It interacts with the regulatory regions of the cyclin E gene, strongly inhibiting transcription. It was also shown to weakly affect cyclib B transcription. PRDM4 is believed to interact with regulatory regions of other genes, which are unknown.", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6P6W3-1", "Q9QZP2-1", "Q4QQW4-1" ], "evidence": [ { "id": "R-RNO-205010", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-205010" } ] } ], "reaction_participants": [ { "participant_id": "R-RNO-194536", "participant_name": "Prdm4 [nucleoplasm]", "crossref": [ { "id": "Q9QZP2", "database": "UniProt", "url": "" }, { "id": "Q9QZP2", "database": "PRO", "url": "" }, { "id": "619929", "database": "RGD", "url": "" }, { "id": "NP_579846.1", "database": "RefSeq", "url": "" } ] }, { "participant_id": "R-RNO-194573", "participant_name": "Prdm4 [cytosol]", "crossref": [ { "id": "619929", "database": "RGD", "url": "" }, { "id": "Q9QZP2", "database": "UniProt", "url": "" }, { "id": "Q9QZP2", "database": "PRO", "url": "" }, { "id": "NP_579846.1", "database": "RefSeq", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "Q4QQW4", "gene_name": "Hdac1", "activity": [ { "ec_number": "3.5.1.-", "activity": "", "evidence": [ { "id": "Q4QQW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4QQW4" } ] }, { "ec_number": "3.5.1.98", "activity": "H2O + N(6)-acetyl-L-lysyl-[histone] = acetate + L-lysyl-[histone].", "evidence": [ { "id": "Q4QQW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4QQW4" } ] }, { "ec_number": "3.5.1.98", "activity": "", "evidence": [ { "id": "Q4QQW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4QQW4" } ] } ] }, { "uniprot_ac": "Q6P6W3", "gene_name": "Hdac3", "activity": [ { "ec_number": "3.5.1.98", "activity": "H2O + N(6)-acetyl-L-lysyl-[histone] = acetate + L-lysyl-[histone].", "evidence": [ { "id": "Q6P6W3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P6W3" } ] }, { "ec_number": "3.5.1.98", "activity": "", "evidence": [ { "id": "Q6P6W3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P6W3" } ] }, { "ec_number": "3.5.1.-", "activity": "", "evidence": [ { "id": "Q6P6W3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P6W3" } ] } ] }, { "uniprot_ac": "Q9QZP2", "gene_name": "Prdm4", "activity": [ { "ec_number": "2.1.1.-", "activity": "", "evidence": [ { "id": "Q9QZP2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QZP2" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }