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skeletal destruction with osteolytic lesions, pathological fractures, bone pain, hypercalcemia, and anemia. 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[], "publication": [ { "title": "Molecular cloning and functional analysis of the mouse homologue of the KILLER/DR5 tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor.", "journal": "Cancer Res.", "date": "1999", "authors": "Wu GS, Burns TF, Zhan Y, Alnemri ES, El-Deiry WS", "evidence": [ { "database": "UniProtKB", "id": "Q9QZM4", "url": "https://www.uniprot.org/uniprot/Q9QZM4" } ], "reference": [ { "type": "PubMed", "id": "10383128", "url": "https://glygen.org/publication/PubMed/10383128" } ] }, { "title": "Induction of tumor-specific T cell immunity by anti-DR5 antibody therapy.", "journal": "The Journal of experimental medicine", "date": "2004", "authors": "Takeda K, Yamaguchi N, Akiba H, Kojima Y, Hayakawa Y, Tanner JE, Sayers TJ, Seki N, Okumura K, Yagita H, Smyth MJ", "evidence": [ { "database": "RefSeq", "id": "NP_064671", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064671" } ], "reference": [ { "type": "PubMed", "id": "14769851", "url": 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Cell. Proteomics", "date": "2019", "authors": "Newson JPM, Scott NE, Yeuk Wah Chung I, Wong Fok Lung T, Giogha C, Gan J, Wang N, Strugnell RA, Brown NF, Cygler M, Pearson JS, Hartland EL", "evidence": [ { "database": "UniProtKB", "id": "Q9QZM4", "url": "https://www.uniprot.org/uniprot/Q9QZM4" } ], "reference": [ { "type": "PubMed", "id": "30902834", "url": "https://glygen.org/publication/PubMed/30902834" } ] }, { "title": "Soluble Fas ligand drives autoantibody-induced arthritis by binding to DR5/TRAIL-R2.", "journal": "eLife", "date": "2021", "authors": "Jeong D, Kim HS, Kim HY, Kang MJ, Jung H, Oh Y, Kim D, Koh J, Cho SY, Jeon YK, Lee EB, Lee SH, Shin EC, Kim HM, Yi EC, Chung DH", "evidence": [ { "database": "RefSeq", "id": "NP_064671", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064671" } ], "reference": [ { "type": "PubMed", "id": "34223817", "url": "https://glygen.org/publication/PubMed/34223817" } ] }, { "title": "TRAIL-R Deficient Mice Are Protected from Neurotoxic Effects of Amyloid-\u03b2.", "journal": "International journal of molecular sciences", "date": "2022-10-01", "authors": "Di Benedetto Giulia, Burgaletto Chiara, Serapide Maria Francesca, Caltabiano Rosario, Munaf\u00f2 Antonio, Bellanca Carlo Maria, Di Mauro Rosaria, Bernardini Renato, Cantarella Giuseppina", "evidence": [ { "database": "RefSeq", "id": "NP_064671", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064671" } ], "reference": [ { "type": "PubMed", "id": "36232931", "url": "https://glygen.org/publication/PubMed/36232931" } ] }, { "title": "TNFRSF10B is involved in motor dysfunction in Parkinson's disease by regulating exosomal \u03b1-synuclein secretion from microglia.", "journal": "Journal of chemical neuroanatomy", "date": "2023-02-13", "authors": "Dai Mingming, Yan Limin, Yu Hang, Chen Changneng, Xie Yuxiang", "evidence": [ { "database": "RefSeq", "id": "NP_064671", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064671" } ], "reference": [ { "type": "PubMed", "id": "36791922", 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