{ "uniprot_canonical_ac": "Q9QWJ9-1", "uniprot_ac": "Q9QWJ9", "uniprot_id": "NRP1_RAT", "mass": { "chemical_mass": 103082.0, "monoisotopic_mass": 103082.0 }, "refseq": { "ac": "NP_659566", "name": "neuropilin-1 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659566" }, "gene_names": [ { "name": "Nrp1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q9QWJ9", "id": "Q9QWJ9" }, { "name": "Nrp1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006255889", "id": "XP_006255889" }, { "name": "Nrp", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006255889", "id": "XP_006255889" } ], "protein_names": [ { "name": "Neuropilin-1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q9QWJ9" }, { "name": "Vascular endothelial cell growth factor 165 receptor", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9QWJ9" }, { "name": "neuropilin-1 isoform X3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006255889", "id": "XP_006255889" }, { "name": "neuropilin-1 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659566", "id": "NP_659566" }, { "name": "vascular endothelial cell growth factor 165 receptor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659566", "id": "NP_659566" } ], "function": [ { "annotation": "Cell-surface receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins. Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage. It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB (By similarity). Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9#function" }, { "database": "UniProtKB", "id": "P97333", "url": "https://www.uniprot.org/uniprot/P97333#function" }, { "database": "UniProtKB", "id": "O14786", "url": "https://www.uniprot.org/uniprot/O14786#function" } ] }, { "annotation": "Decreased expression of Sema3A/Nrp1 was observed in periapical lesions and is potentially involved in the bone resorption of the periapical area, suggesting that Sema3A/Nrp1 may contribute to the pathological development of apical periodontitis", "evidence": [ { "database": "RefSeq", "id": "NP_659566", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659566" }, { "database": "PubMed", "id": "29457037", "url": "https://glygen.org/publication/PubMed/29457037" } ] }, { "annotation": "Long non-coding RNA THRIL inhibits miRNA-24-3p to upregulate neuropilin-1 to aggravate cerebral ischemia-reperfusion injury through regulating the nuclear factor kappaB p65 signaling.", "evidence": [ { "database": "RefSeq", "id": "NP_659566", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659566" }, { "database": "PubMed", "id": "33675584", "url": "https://glygen.org/publication/PubMed/33675584" } ] }, { "annotation": "Neuropilin-1 receptor in the rapid and selective estrogen-induced neurovascular remodeling of rat uterus. Erratum:[Cell Tissue Res. 2020 Jun 15;:. PMID: 32542406]", "evidence": [ { "database": "RefSeq", "id": "NP_659566", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659566" }, { "database": "PubMed", "id": "32242249", "url": "https://glygen.org/publication/PubMed/32242249" } ] } ], "disease": [ { "disease_id": "DOID:1727", "recommended_name": { "id": "DOID:1727", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1727", "name": "retinal vein occlusion", "description": "" }, "synonyms": [ { "id": "DOID:1727", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1727", "name": "Occlusion, of retinal vein", "description": "" } ], "evidence": [ { "id": "1727", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1727" } ] }, { "disease_id": "DOID:3908", "recommended_name": { "id": "DOID:3908", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3908", "name": "lung non-small cell carcinoma", "description": "A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma." }, "synonyms": [ { "id": "DOID:3908", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3908", "name": "NSCLC", "description": "" }, { "id": "DOID:3908", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3908", "name": "Non-small cell lung cancer", "description": "" }, { "id": "DOID:3908", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3908", "name": "non-small cell lung carcinoma", "description": "" } ], "evidence": [ { "id": "3908", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3908" } ] }, { "disease_id": "DOID:684", "recommended_name": { "id": "DOID:684", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:684", "name": "hepatocellular carcinoma", "description": "A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver." }, "synonyms": [ { "id": "DOID:684", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:684", "name": "Hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation." }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "HCC", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "cancer, hepatocellular", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma, hepatocellular, malignant", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular adenocarcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, childhood type, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell cancer (hepatocellular carcinoma)", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult primary hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma caused by somatic mutation", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver and intrahepatic bile duct carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cancer", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation." }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "HCC", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "cancer, hepatocellular", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "carcinoma, hepatocellular, malignant", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular adenocarcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular cancer, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, childhood type, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatocellular carcinoma, somatic", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell cancer (hepatocellular carcinoma)", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cell carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "primary carcinoma of the liver cells", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult hepatoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "adult primary hepatocellular carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "hepatoblastoma caused by somatic mutation", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver and intrahepatic bile duct carcinoma", "description": "" }, { "id": "MONDO:0007256", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007256", "name": "liver cancer", "description": "" }, { "id": "MIM:114550", "resource": "MIM", "url": "https://www.omim.org/entry/114550", "name": "Hepatocellular carcinoma", "description": "Hepatocellular carcinoma" } ], "evidence": [ { "id": "684", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:684" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "common_name": "Rat" } ], "gene": [ { "name": "Nrp1", "url": "https://www.uniprot.org/uniprot/Q9QWJ9", "locus": { "chromosome": "19", "start_pos": 56513633, "end_pos": 56359455, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000010744", "url": "https://www.ensembl.org/id/ENSRNOG00000010744" } ] } } ], "crossref": [ { "id": "ENSRNOG00000010744", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000010744", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00041", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00041", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00057", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00057", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd06263", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06263", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "CHEMBL3309098", "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL3309098", "database": "ChEMBL", "categories": [ "Other" ] }, { "id": "246331", "url": "https://www.ncbi.nlm.nih.gov/gene/246331", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q9QWJ9", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q9QWJ9*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000421", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000421", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000859", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000859", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000998", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000998", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014648", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014648", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR022579", "url": "https://www.ebi.ac.uk/interpro/entry/IPR022579", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035914", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035914", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "rno:246331", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:246331", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "QEDCTKP", "url": "https://omabrowser.org/oma/group/QEDCTKP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5293253at2759", "url": "http://www.orthodb.org/?query=5293253at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46806", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46806", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46806:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46806:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "2ORX", "url": "https://www.rcsb.org/structure/2ORX", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "2ORZ", "url": "https://www.rcsb.org/structure/2ORZ", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00431", "url": "http://pfam.xfam.org/family/PF00431", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00629", "url": "http://pfam.xfam.org/family/PF00629", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00754", "url": "http://pfam.xfam.org/family/PF00754", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF11980", "url": "http://pfam.xfam.org/family/PF11980", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q9QWJ9", "url": "http://purl.obolibrary.org/obo/PR_Q9QWJ9", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-194306", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-194306", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-399954", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-399954", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-399955", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-399955", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-399956", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-399956", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-RNO-445144", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-445144", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_659566", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659566", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "621588", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=621588", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A8I5ZTD9", "url": "https://www.uniprot.org/uniprot/A0A8I5ZTD9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZTD9-1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZTD9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6A3Y3", "url": "https://www.uniprot.org/uniprot/A0A8I6A3Y3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I6A3Y3-1", "url": "https://www.uniprot.org/uniprot/A0A8I6A3Y3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8L2R9S2", "url": "https://www.uniprot.org/uniprot/A0A8L2R9S2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8L2R9S2-1", "url": "https://www.uniprot.org/uniprot/A0A8L2R9S2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9QWJ9-1", "url": "https://www.uniprot.org/uniprot/Q9QWJ9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MERGLPLLCATLALALALAGAFRSDKCGGTIKIENPGYLTSPGYPHSYHPSEKCEWLIQAPEPYQRIMINFNPHFDLEDRDCKYDYVEVIDGENEGGRLWGKFCGKIAPSPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTAPTGVIKSPGFPEKYPNSLECTYIIFAPKMSEIILEFESFDLEQDSNPPGGVFCRYDRLEIWDGFPEVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSISEDFKCMEALGMESGEIHSDQITASSQYGTNWSVERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYRVDISSNGEDWITLKEGNKAIIFQGNTNPTDVVFGVFPKPLITRFVRIKPASWETGISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITASNQGDRNWMPENIRLVTSRTGWALPPSPHPYINEWLQVDLGDEKIVRGVIIQGGKHRENKVFMRKFKIAYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRAFTPLSTRFIRIYPERATHSGLGLRMELLGCEVEVPTAGPTTPNGNPVDECDDDQANCHSGTGDDFQLTGGTTVLATEKPTIIDSTIQSEFPTYGFNCEFGWGSHKTFCHWEHDSHAQLRWRVLTSKTGPIQDHTGDGNFIYSQADENQKGKVARLVSPVVYSQSSAHCMTFWYHMSGSHVGTLRVKLHYQKPEEYDQLVWMVVGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDISINNHIPQEDCAKPTDLDKKNTEIKIDETGSTPGYEEGKGDKNISRKPGNVLKTLDPILITIIAMSALGVLLGAVCGVVLYCACWHNGMSERNLSALENYNFELVDGVKLKKDKLNPQSNYSEA", "length": 922, "header": "sp|Q9QWJ9-1|NRP1_RAT Isoform 1 of Neuropilin-1 OS=Rattus norvegicus OX=10116 GN=Nrp1 PE=1 SV=1 CANONICAL=Q9QWJ9-1" }, "isoforms": [ { "isoform_ac": "A0A8I5ZTD9-1", "url": "", "sequence": { "sequence": "MERGLPLLCATLALALALAGAFRSDKCGGTIKIENPGYLTSPGYPHSYHPSEKCEWLIQAPEPYQRIMINFNPHFDLEDRDCKYDYVEVIDGENEGGRLWGKFCGKIAPSPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTAPTGVIKSPGFPEKYPNSLECTYIIFAPKMSEIILEFESFDLEQDSNPPGGVFCRYDRLEIWDGFPEVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSISEDFKCMEALGMESGEIHSDQITASSQYGTNWSVERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYRVDISSNGEDWITLKEGNKAIIFQGNTNPTDVVFGVFPKPLITRFVRIKPASWETGISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITASNQGDRNWMPENIRLVTSRTGWALPPSPHPYINEWLQVDLGDEKIVRGVIIQGGKHRENKVFMRKFKIAYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRAFTPLSTRFIRIYPERATHSGLGLRMELLGCEVEVPTAGPTTPNGNPVDECDDDQANCHSGTGDDFQLTGAEPTLIPSLCLFPTYGFNCEFGWGSHKTFCHWEHDSHAQLRWRVLTSKTGPIQDHTGDGNFIYSQADENQKGKVARLVSPVVYSQSSAHCMTFWYHMSGSHVGTLRVKLHYQKPEEYDQLVWMVVGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDISINNHIPQEDCAKPTDLDKKNTEIKIDETGSTPGYEEGKGDKNISRKPGNVLKTLDPILITIIAMSALGVLLGAVCGVVLYCACWHNGMSERNLSALENYNFELVDGVKLKKDKLNPQSNYSEA", "length": 913, "header": "tr|A0A8I5ZTD9-1|NRP1_RAT Computationally mapped isoform of Neuropilin-1 OS=Rattus norvegicus OX=10116 GN=Nrp1 PE=1 SV=1 CANONICAL=Q9QWJ9-1" }, "locus": { "chromosome": "19", "start_pos": 56512040, "end_pos": 56361732, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000108605.1", "url": "https://www.ensembl.org/id/ENSRNOT00000108605.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000082340.1", "url": "https://www.ensembl.org/id/ENSRNOP00000082340.1" } ] } }, { "isoform_ac": "A0A8I6A3Y3-1", "url": "", "sequence": { "sequence": "QWPGLPLTFSNKCGGTIKIENPGYLTSPGYPHSYHPSEKCEWLIQAPEPYQRIMINFNPHFDLEDRDCKYDYVEVIDGENEGGRLWGKFCGKIAPSPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTAPTGVIKSPGFPEKYPNSLECTYIIFAPKMSEIILEFESFDLEQDSNPPGGVFCRYDRLEIWDGFPEVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSISEDFKCMEALGMESGEIHSDQITASSQYGTNWSVERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYRVDISSNGEDWITLKEGNKAIIFQGNTNPTDVVFGVFPKPLITRFVRIKPASWETGISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITASNQGDRNWMPENIRLVTSRTGWALPPSPHPYINEWLQVDLGDEKIVRGVIIQGGKHRENKVFMRKFKIAYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRAFTPLSTRFIRIYPERATHSGLGLRMELLGCEVEVPTAGPTTPNGNPVDECDDDQANCHSGTGDDFQLTGAEPTLIPSLCLFPTYGFNCEFGWGSHKTFCHWEHDSHAQLRWRVLTSKTGPIQDHTGDGNFIYSQADENQKGKVARLVSPVVYSQSSAHCMTFWYHMSGSHVGTLRVKLHYQKPEEYDQLVWMVVGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDISINNHIPQEDCAKPTDLDKKNTEIKIDETGSTPGYEEGKGDKNISRKPGNVLKTLDPILITIIAMSALGVLLGAVCGVVLYCACWHNGMSERNLSALENYNFELVDGVKLKKDKLNPQSNYSEA", "length": 899, "header": "tr|A0A8I6A3Y3-1|A0A8I6A3Y3_RAT Computationally mapped isoform of Neuropilin OS=Rattus norvegicus OX=10116 GN=Nrp1 PE=1 SV=1 CANONICAL=Q9QWJ9-1" }, "locus": { "chromosome": "19", "start_pos": 56512040, "end_pos": 56364664, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000114861.1", "url": "https://www.ensembl.org/id/ENSRNOT00000114861.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000085705.1", "url": "https://www.ensembl.org/id/ENSRNOP00000085705.1" } ] } }, { "isoform_ac": "A0A8L2R9S2-1", "url": "", "sequence": { "sequence": "MERGLPLLCATLALALALAGAFRSDKCGGTIKIENPGYLTSPGYPHSYHPSEKCEWLIQAPEPYQRIMINFNPHFDLEDRDCKYDYVEVIDGENEGGRLWGKFCGKIAPSPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTAPTGVIKSPGFPEKYPNSLECTYIIFAPKMSEIILEFESFDLEQDSNPPGGVFCRYDRLEIWDGFPEVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSISEDFKCMEALGMESGEIHSDQITASSQYGTNWSVERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYRVDISSNGEDWITLKEGNKAIIFQGNTNPTDVVFGVFPKPLITRFVRIKPASWETGISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITASNQGDRNWMPENIRLVTSRTGWALPPSPHPYINEWLQVDLGDEKIVRGVIIQGGKHRENKVFMRKFKIAYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRAFTPLSTRFIRIYPERATHSGLGLRMELLGCEVEVPTAGPTTPNGNPVDECDDDQANCHSGTGDDFQLTGGTTVLATEKPTIIDSTIQSEFPTYGFNCEFGWGSHKTFCHWEHDSHAQLRWRVLTSKTGPIQDHTGDGNFIYSQADENQKGKVARLVSPVVYSQSSAHCMTFWYHMSGSHVGTLRVKLHYQKPEEYDQLVWMVVGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDISINNHIPQEDCARSTPGYEEGKGDKNISRKPGNVLKTLDPILITIIAMSALGVLLGAVCGVVLYCACWHNGMSERNLSALENYNFELVDGVKLKKDKLNPQSNYSEA", "length": 905, "header": "tr|A0A8L2R9S2-1|NRP1_RAT Computationally mapped isoform of Neuropilin-1 OS=Rattus norvegicus OX=10116 GN=Nrp1 PE=1 SV=1 CANONICAL=Q9QWJ9-1" }, "locus": { "chromosome": "19", "start_pos": 56512040, "end_pos": 56361732, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000080465.2", "url": "https://www.ensembl.org/id/ENSRNOT00000080465.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000075034.2", "url": "https://www.ensembl.org/id/ENSRNOP00000075034.2" } ] } }, { "isoform_ac": "Q9QWJ9-1", "url": "", "sequence": { "sequence": "MERGLPLLCATLALALALAGAFRSDKCGGTIKIENPGYLTSPGYPHSYHPSEKCEWLIQAPEPYQRIMINFNPHFDLEDRDCKYDYVEVIDGENEGGRLWGKFCGKIAPSPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTAPTGVIKSPGFPEKYPNSLECTYIIFAPKMSEIILEFESFDLEQDSNPPGGVFCRYDRLEIWDGFPEVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSISEDFKCMEALGMESGEIHSDQITASSQYGTNWSVERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYRVDISSNGEDWITLKEGNKAIIFQGNTNPTDVVFGVFPKPLITRFVRIKPASWETGISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITASNQGDRNWMPENIRLVTSRTGWALPPSPHPYINEWLQVDLGDEKIVRGVIIQGGKHRENKVFMRKFKIAYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRAFTPLSTRFIRIYPERATHSGLGLRMELLGCEVEVPTAGPTTPNGNPVDECDDDQANCHSGTGDDFQLTGGTTVLATEKPTIIDSTIQSEFPTYGFNCEFGWGSHKTFCHWEHDSHAQLRWRVLTSKTGPIQDHTGDGNFIYSQADENQKGKVARLVSPVVYSQSSAHCMTFWYHMSGSHVGTLRVKLHYQKPEEYDQLVWMVVGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDISINNHIPQEDCAKPTDLDKKNTEIKIDETGSTPGYEEGKGDKNISRKPGNVLKTLDPILITIIAMSALGVLLGAVCGVVLYCACWHNGMSERNLSALENYNFELVDGVKLKKDKLNPQSNYSEA", "length": 922, "header": "sp|Q9QWJ9-1|NRP1_RAT Isoform 1 of Neuropilin-1 OS=Rattus norvegicus OX=10116 GN=Nrp1 PE=1 SV=1 CANONICAL=Q9QWJ9-1" }, "locus": { "chromosome": "19", "start_pos": 56512040, "end_pos": 56361732, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000014492", "url": "https://www.ensembl.org/id/ENSRNOT00000014492" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000014492", "url": "https://www.ensembl.org/id/ENSRNOP00000014492" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 150, "start_aa": "Asn", "end_pos": 150, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn150", "evidence": [ { "id": "Q9QWJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QWJ9#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 261, "start_aa": "Asn", "end_pos": 261, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn261", "evidence": [ { "id": "Q9QWJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QWJ9#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 300, "start_aa": "Asn", "end_pos": 300, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn300", "evidence": [ { "id": "Q9QWJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QWJ9#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 522, "start_aa": "Asn", "end_pos": 522, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn522", "evidence": [ { "id": "Q9QWJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QWJ9#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "site_category": "predicted", "site_seq": "S", "relation": "attached", "comment": "O-linked (Xyl...) (heparan sulfate) serine; alternate", "start_pos": 612, "start_aa": "Ser", "end_pos": 612, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser612", "evidence": [ { "id": "Q9QWJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QWJ9#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "O-linked", "subtype": "", "site_category": "predicted", "site_seq": "S", "relation": "attached", "comment": "O-linked (Xyl...) (chondroitin sulfate) serine", "start_pos": 829, "start_aa": "Ser", "end_pos": 829, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser829", "evidence": [ { "id": "Q9QWJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QWJ9#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 841, "start_aa": "Asn", "end_pos": 841, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn841", "evidence": [ { "id": "Q9QWJ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QWJ9#ptm_processing" } ] } ], "phosphorylation": [ { "start_pos": 893, "end_pos": 893, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "site_lbl": "Ser893" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Structural basis for ligand and heparin binding to neuropilin B domains.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2007", "authors": "Bellamy H.D., Leahy D.J., Vander Kooi C.W., Neau D.B., Perman B., Jusino M.A.", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "reference": [ { "type": "PubMed", "id": "17405859", "url": "https://glygen.org/publication/PubMed/17405859" } ] }, { "title": "Expression of Semaphorins, Neuropilins, VEGF, and Tenascins in Rat and Human Primary Sensory Neurons after a Dorsal Root Injury.", "journal": "Front. Neurol.", "date": "2017", "authors": "Carlstedt T., Cullheim S., Hammarberg H., Lindholm T., Risling M., Skoeld M.K., Wallquist W.", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "reference": [ { "type": "PubMed", "id": "28270793", "url": "https://glygen.org/publication/PubMed/28270793" } ] }, { "title": "Decreased Expression of Semaphorin3A/Neuropilin-1 Signaling Axis in Apical Periodontitis.", "journal": "BioMed research international", "date": "2017", "authors": "Lin Y, Xing Q, Qin W, de Melo MAS, Zou R, Xu M, Zhang X, Xu HHK, Lin Z", "evidence": [ { "database": "RefSeq", "id": "NP_659566", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659566" } ], "reference": [ { "type": "PubMed", "id": "29457037", "url": "https://glygen.org/publication/PubMed/29457037" } ] }, { "title": "Neuropilin-1 receptor in the rapid and selective estrogen-induced neurovascular remodeling of rat uterus.", "journal": "Cell and tissue research", "date": "2020", "authors": "Richeri A, Vierci G, Martinez GF, Latorre MP, Chalar C, Brauer MM", "evidence": [ { "database": "RefSeq", "id": "NP_659566", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659566" } ], "reference": [ { "type": "PubMed", "id": "32242249", "url": "https://glygen.org/publication/PubMed/32242249" } ] }, { "title": "Long non-coding RNA THRIL inhibits miRNA-24-3p to upregulate neuropilin-1 to aggravate cerebral ischemia-reperfusion injury through regulating the nuclear factor kappaB p65 signaling.", "journal": "Aging", "date": "2021", "authors": "Kuai F, Zhou L, Zhou J, Sun X, Dong W", "evidence": [ { "database": "RefSeq", "id": "NP_659566", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659566" } ], "reference": [ { "type": "PubMed", "id": "33675584", "url": "https://glygen.org/publication/PubMed/33675584" } ] }, { "title": "Neuropilin is a semaphorin III receptor.", "journal": "Cell", "date": "1997", "authors": "Giger R.J., Kolodkin A.L., Tai Y.-T., Ginty D.D., Levengood D.V., Rowe E.G.", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "reference": [ { "type": "PubMed", "id": "9288754", "url": "https://glygen.org/publication/PubMed/9288754" } ] } ], "pathway": [ { "id": "rno:246331", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:246331", "resource": "KEGG Pathway" }, { "id": "R-RNO-194306", "name": "Neurophilin interactions with VEGF and VEGFR", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-194306", "resource": "Reactome", "description": "Neurophilin interactions with VEGF and VEGFR" }, { "id": "R-RNO-399954", "name": "Sema3A PAK dependent Axon repulsion", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-399954", "resource": "Reactome", "description": "Sema3A PAK dependent Axon repulsion" }, { "id": "R-RNO-399955", "name": "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-399955", "resource": "Reactome", "description": "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion" }, { "id": "R-RNO-399956", "name": "CRMPs in Sema3A signaling", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-399956", "resource": "Reactome", "description": "CRMPs in Sema3A signaling" }, { "id": "R-RNO-445144", "name": "Signal transduction by L1", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-445144", "resource": "Reactome", "description": "Signal transduction by L1" } ], "orthologs": [ { "uniprot_canonical_ac": "O14786-1", "protein_name": "Neuropilin-1", "gene_name": "NRP1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MERGLPLLCAVLALVLAPAGAFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFVPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYSTNWSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSYINEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTFPALSTRFIRIYPERATHGGLGLRMELLGCEVEAPTAGPTTPNGNLVDECDDDQANCHSGTGDDFQLTGGTTVLATEKPTVIDSTIQSEFPTYGFNCEFGWGSHKTFCHWEHDNHVQLKWSVLTSKTGPIQDHTGDGNFIYSQADENQKGKVARLVSPVVYSQNSAHCMTFWYHMSGSHVGTLRVKLRYQKPEEYDQLVWMAIGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDISINNHISQEDCAKPADLDKKNPEIKIDETGSTPGYEGEGEGDKNISRKPGNVLKTLDPILITIIAMSALGVLLGAVCGVVLYCACWHNGMSERNLSALENYNFELVDGVKLKKDKLNTQSTYSEA", "length": 923 }, "evidence": [ { "id": "45225216", "url": "http://www.informatics.jax.org/homology/45225216", "database": "MGI" }, { "id": "Q9QWJ9", "url": "https://omabrowser.org/oma/group/Q9QWJ9/", "database": "OMA" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "P97333-1", "protein_name": "Neuropilin-1", "gene_name": "Nrp1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": 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"name": "sympathetic neuron projection guidance", "id": "GO:0097491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097491", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "semaphorin-plexin signaling pathway involved in neuron projection guidance", "id": "GO:1902285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902285", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "motor neuron migration", "id": "GO:0097475", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097475", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "vasculogenesis", "id": "GO:0001570", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001570", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "integrin-mediated signaling pathway", "id": "GO:0007229", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007229", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "heart development", "id": "GO:0007507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007507", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "dendrite development", "id": "GO:0016358", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016358", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "positive regulation of ERK1 and ERK2 cascade", "id": "GO:0070374", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070374", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "semaphorin-plexin signaling pathway", "id": "GO:0071526", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071526", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "neuron migration", "id": "GO:0001764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001764", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "positive regulation of endothelial cell migration", "id": "GO:0010595", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010595", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "positive regulation of angiogenesis", "id": "GO:0045766", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045766", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "negative regulation of neuron apoptotic process", "id": "GO:0043524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043524", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "response to wounding", "id": "GO:0009611", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009611", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "positive regulation of stress fiber assembly", "id": "GO:0051496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051496", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "neural crest cell migration", "id": "GO:0001755", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001755", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "regulation of Cdc42 protein signal transduction", "id": "GO:0032489", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032489", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "substrate adhesion-dependent cell spreading", "id": "GO:0034446", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034446", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "neuropilin signaling pathway", "id": "GO:0038189", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038189", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "endothelial cell migration", "id": "GO:0043542", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043542", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "positive regulation of peptidyl-tyrosine phosphorylation", "id": "GO:0050731", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050731", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "positive regulation of focal adhesion assembly", "id": "GO:0051894", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051894", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "positive regulation of cell migration involved in sprouting angiogenesis", "id": "GO:0090050", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090050", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "positive regulation of substrate adhesion-dependent cell spreading", "id": "GO:1900026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900026", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "vascular endothelial growth factor receptor signaling pathway", "id": "GO:0048010", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048010", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "retina vasculature development in camera-type eye", "id": "GO:0061298", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061298", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "positive regulation of phosphorylation", "id": "GO:0042327", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042327", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "blood vessel endothelial cell migration", "id": "GO:0043534", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043534", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "branching involved in blood vessel morphogenesis", "id": "GO:0001569", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001569", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "sprouting angiogenesis", "id": "GO:0002040", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002040", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "negative regulation of extrinsic apoptotic signaling pathway", "id": "GO:2001237", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001237", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "axonal fasciculation", "id": "GO:0007413", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007413", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "nerve development", "id": "GO:0021675", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021675", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "cellular response to vascular endothelial growth factor stimulus", "id": "GO:0035924", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035924", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "neuron development", "id": "GO:0048666", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048666", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "positive regulation of filopodium assembly", "id": "GO:0051491", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051491", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "sympathetic nervous system development", "id": "GO:0048485", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048485", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "artery morphogenesis", "id": "GO:0048844", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048844", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "positive chemotaxis", "id": "GO:0050918", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050918", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "platelet-derived growth factor receptor signaling pathway", "id": "GO:0048008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048008", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "coronary artery morphogenesis", "id": "GO:0060982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060982", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "retina vasculature morphogenesis in camera-type eye", "id": "GO:0061299", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061299", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "sympathetic ganglion development", "id": "GO:0061549", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061549", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "axon extension", "id": "GO:0048675", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048675", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "substrate-dependent cell migration, cell extension", "id": "GO:0006930", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006930", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "endothelial cell chemotaxis", "id": "GO:0035767", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035767", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "axonogenesis involved in innervation", "id": "GO:0060385", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060385", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "regulation of vascular endothelial growth factor receptor signaling pathway", "id": "GO:0030947", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030947", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "sensory neuron axon guidance", "id": "GO:0097374", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097374", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "regulation of axon extension involved in axon guidance", "id": "GO:0048841", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048841", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "cellular response to hepatocyte growth factor stimulus", "id": "GO:0035729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035729", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "hepatocyte growth factor receptor signaling pathway", "id": "GO:0048012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048012", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "motor neuron axon guidance", "id": "GO:0008045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008045", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": "https://www.uniprot.org/uniprot/Q9QWJ9" } ], "pmid": "" }, { "name": "cell migration involved in sprouting angiogenesis", "id": "GO:0002042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002042", "evidence": [ { "database": "UniProtKB", "id": "Q9QWJ9", "url": 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