{ "uniprot_canonical_ac": "Q9NRS4-1", "uniprot_ac": "Q9NRS4", "uniprot_id": "TMPS4_HUMAN", "mass": { "chemical_mass": 48246.0, "monoisotopic_mass": 48246.0 }, "refseq": { "ac": "NP_001077416", "name": "transmembrane protease serine 4 isoform 3", "summary": "This gene encodes a member of the serine protease family. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified as a gene overexpressed in pancreatic carcinoma. The encoded protein is membrane bound with a N-terminal anchor sequence and a glycosylated extracellular region containing the serine protease domain. The protein has been found to promote SARS-CoV-2 entry into host cells. [provided by RefSeq, Aug 2021].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077416" }, "gene_names": [ { "name": "TMPRSS4", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q9NRS4", "id": "Q9NRS4" }, { "name": "CAP2; CAPH2; MT-SP2; TMPRSS3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077416", "id": "NP_001077416" }, { "name": "PRO1570", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9NRS4", "id": "Q9NRS4" }, { "name": "TMPRSS3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9NRS4", "id": "Q9NRS4" }, { "name": "TMPRSS4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077416", "id": "NP_001077416" }, { "name": "hCG_41152", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9NRS4", "id": "Q9NRS4" } ], "protein_names": [ { "name": "Transmembrane protease serine 4", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q9NRS4" }, { "name": "3.4.21.-", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9NRS4" }, { "name": "CAPH2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9NRS4" }, { "name": "Channel-activating protease 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9NRS4" }, { "name": "MT-SP2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9NRS4" }, { "name": "Membrane-type serine protease 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9NRS4" }, { "name": "transmembrane protease serine 4 isoform 3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077416", "id": "NP_001077416" }, { "name": "transmembrane serine protease 3; membrane-type serine protease 2; type II membrane serine protease; channel-activating protease 2; transmembrane protease, serine 4; channel-activating serine protease 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077416", "id": "NP_001077416" } ], "function": [ { "annotation": "(Microbial infection) In gut epithelial cells, facilitates human coronavirus SARS-CoV-2 infection through, at least, the cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry.", "evidence": [ { "database": "UniProtKB", "id": "Q9NRS4", "url": "https://www.uniprot.org/uniprot/Q9NRS4#function" }, { "database": "PubMed", "id": "32404436", "url": "https://glygen.org/publication/PubMed/32404436" } ] }, { "annotation": "Increased TRIM31 gene expression is positively correlated with SARS-CoV-2 associated genes TMPRSS2 and TMPRSS4 in gastrointestinal cancers. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001077416", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077416" }, { "database": "PubMed", "id": "35970857", "url": "https://glygen.org/publication/PubMed/35970857" } ] }, { "annotation": "Plasma membrane-anchored serine protease that directly induces processing of pro-uPA/PLAU into the active form through proteolytic activity (PubMed:24434139). Seems to be capable of activating ENaC (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q9NRS4", "url": "https://www.uniprot.org/uniprot/Q9NRS4#function" }, { "database": "UniProtKB", "id": "Q8VCA5", "url": "https://www.uniprot.org/uniprot/Q8VCA5#function" }, { "database": "PubMed", "id": "24434139", "url": "https://glygen.org/publication/PubMed/24434139" } ] }, { "annotation": "RNAi-mediated knockdown of TMPRSS2 and TMPRSS4 in Caco-2 cells, which released fully infectious virus without trypsin treatment, markedly reduced the spread of influenza virus, demonstrating that these proteases were responsible for activation of HA.", "evidence": [ { "database": "RefSeq", "id": "NP_001077416", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077416" }, { "database": "PubMed", "id": "20631123", "url": "https://glygen.org/publication/PubMed/20631123" } ] }, { "annotation": "TMPRSS4 expression was significantly higher in human colorectal cancer tissues from advanced stages than in that of early stage.", "evidence": [ { "database": "RefSeq", "id": "NP_001077416", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077416" }, { "database": "PubMed", "id": "20118200", "url": "https://glygen.org/publication/PubMed/20118200" } ] }, { "annotation": "TMPRSS4 is a novel biomarker and correlated with immune infiltration in thyroid carcinoma. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001077416", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077416" }, { "database": "PubMed", "id": "36380313", "url": "https://glygen.org/publication/PubMed/36380313" } ] }, { "annotation": "TMPRSS4 overexpression promotes the metastasis of colorectal cancer and predicts poor prognosis of stage III-IV colorectal cancer.", "evidence": [ { "database": "RefSeq", "id": "NP_001077416", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077416" }, { "database": "PubMed", "id": "34595980", "url": "https://glygen.org/publication/PubMed/34595980" } ] }, { "annotation": "TMPRSS4 plays a role in invasion, metastasis, migration and adhesion in cancer cells. TMPRSS4 may contribute to tumor cell invasion and metastasis by promoting an epithelial-mesenchymal transition(EMT) through the strong SIP1/ZEB2 induction.", "evidence": [ { "database": "RefSeq", "id": "NP_001077416", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077416" }, { "database": "PubMed", "id": "17968309", "url": "https://glygen.org/publication/PubMed/17968309" } ] }, { "annotation": "The authors provide evidence that TMPRSS2 and TMPRSS4 activate the 1918 HA by cleavage and therefore may promote viral spread in lung tissue.", "evidence": [ { "database": "RefSeq", "id": "NP_001077416", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077416" }, { "database": "PubMed", "id": "19158246", "url": "https://glygen.org/publication/PubMed/19158246" } ] }, { "annotation": "This gene encodes a member of the serine protease family. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified as a gene overexpressed in pancreatic carcinoma. The encoded protein is membrane bound with a N-terminal anchor sequence and a glycosylated extracellular region containing the serine protease domain. The protein has been found to promote SARS-CoV-2 entry into host cells. [provided by RefSeq, Aug 2021].", "evidence": [ { "database": "RefSeq", "id": "NP_001077416", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077416" } ] }, { "annotation": "Transmembrane Protease TMPRSS4 Promotes the Formation and Development of Mismatch Repair Deficient Colon Cancer Liver Metastasis. Erratum:[Bull Exp Biol Med. 2021 Nov;172(1):112. PMID: 34796428]", "evidence": [ { "database": "RefSeq", "id": "NP_001077416", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077416" }, { "database": "PubMed", "id": "34173918", "url": "https://glygen.org/publication/PubMed/34173918" } ] }, { "annotation": "Utility of TMPRSS4 as a Prognostic Biomarker and Potential Therapeutic Target in Patients with Gastric Cancer.", "evidence": [ { "database": "RefSeq", "id": "NP_001077416", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077416" }, { "database": "PubMed", "id": "34379296", "url": "https://glygen.org/publication/PubMed/34379296" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs756332113", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs756332113" }, { "id": "rs756332113", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs756332113" }, { "id": "rs756332113", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs756332113" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 180, "end_pos": 180, "sequence_org": "S", "sequence_mut": "G", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NSS->NSG).", "chr_id": "11", "chr_pos": "118107871", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S180", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs764260181", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs764260181" }, { "id": "rs764260181", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs764260181" }, { "id": "rs764260181", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs764260181" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 180, "end_pos": 180, "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NSS->NSN).", "chr_id": "11", "chr_pos": "118107872", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S180", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1314451795", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1314451795" }, { "id": "rs1314451795", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1314451795" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 249, "end_pos": 249, "sequence_org": "K", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (KHT->NHT).", "chr_id": "11", "chr_pos": "118113386", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "K249", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "Q9NRS4", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9NRS4" } ], "glycoeffect": [], "start_pos": 98, "end_pos": 98, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "E", "sequence_mut": "K", "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (3).", "chr_id": "11", "chr_pos": "118103235", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "E98", "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": 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"http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { 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"url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] }, { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "mutagenesis": [ { "start_pos": 290, "end_pos": 290, "sequence_org": "D", "sequence_mut": "A", "comment": "Abolishes protease activity.", "evidence": [ { "database": "UniProtKB", "id": "Q9NRS4", "url": "https://www.uniprot.org/uniprot/Q9NRS4" }, { "database": "PubMed", "id": "24434139", "url": "https://glygen.org/publication/PubMed/24434139" } ] }, { "start_pos": 387, "end_pos": 387, "sequence_org": "S", "sequence_mut": "A", "comment": "Abolishes protease activity.", "evidence": [ { "database": "UniProtKB", "id": "Q9NRS4", "url": "https://www.uniprot.org/uniprot/Q9NRS4" }, { "database": "PubMed", "id": "24434139", "url": "https://glygen.org/publication/PubMed/24434139" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": 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"database": "Bgee", "id": "ENSG00000137648", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000137648" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "49.2", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000137648", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000137648" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "97.7", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000137648", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000137648" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "89.26", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000137648", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000137648" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "87.23", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000137648", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000137648" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "51.77", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000137648", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000137648" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "70.05", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000137648", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000137648" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "54.65", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000137648", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000137648" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "69.24", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000137648", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000137648" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "51.24", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000137648", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000137648" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "Q9NRS4", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q9NRS4" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": 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"MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Breast cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1612", "evidence": [ { "database": "BioXpress", "id": "Q9NRS4", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q9NRS4" } ], "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed 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Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "Q9NRS4", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q9NRS4" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q9NRS4" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "No", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { 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"https://www.uniprot.org/uniprot/H0YBM5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0YBM5-1", "url": "https://www.uniprot.org/uniprot/H0YBM5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9NRS4", "url": "https://www.uniprot.org/uniprot/Q9NRS4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9NRS4-1", "url": "https://www.uniprot.org/uniprot/Q9NRS4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9NRS4-2", "url": "https://www.uniprot.org/uniprot/Q9NRS4-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9NRS4-3", "url": "https://www.uniprot.org/uniprot/Q9NRS4-3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9NRS4-4", "url": "https://www.uniprot.org/uniprot/Q9NRS4-4", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLQDPDSDQPLNSLDVKPLRKPRIPMETFRKVGIPIIIALLSLASIIIVVVLIKVILDKYYFLCGQPLHFIPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALAETACRQMGYSSKPTFRAVEIGPDQDLDVVEITENSQELRMRNSSGPCLSGSLVSLHCLACGKSLKTPRVVGVEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWIYNVWKAEL", "length": 437, "header": "sp|Q9NRS4-1|TMPS4_HUMAN Isoform 1 of Transmembrane protease serine 4 OS=Homo sapiens OX=9606 GN=TMPRSS4 PE=1 SV=2 CANONICAL=Q9NRS4-1" }, "isoforms": [ { "isoform_ac": "A0A087WTU6-1", "url": "", "sequence": { "sequence": "MLQDPDSDQPLNSLVKVILDKYYFLCGQPLHFIPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALAETACRQMGYSSKPTFRAVEIGPDQDLDVVEITENSQELRMRNSSGPCLSGSLVSLHCLACGKSLKTPRVVGVEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWIYNVWKAEL", "length": 399, "header": "tr|A0A087WTU6-1|A0A087WTU6_HUMAN Computationally mapped isoform of Transmembrane serine protease 4 OS=Homo sapiens OX=9606 GN=TMPRSS4 PE=1 SV=1 CANONICAL=Q9NRS4-1" }, "locus": { "chromosome": "11", "start_pos": 118117910, "end_pos": 118077303, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000616579.4", "url": "https://www.ensembl.org/id/ENST00000616579.4" }, { "database": "Ensembl Peptide", "id": "ENSP00000478147.1", "url": "https://www.ensembl.org/id/ENSP00000478147.1" } ] } }, { "isoform_ac": "E5RIH1-1", "url": "", "sequence": { "sequence": "MDPDSDQPLNSLDVKPLRKPRIPMETFRKVGIPIIIALLSLASIIIVVVLIRLSKDRSTLQVLDSATGNWFSACFDNFTEALAETACRQMGYSSKPTFRAVEIGPDQDLDVVEITENSQELRMRNSSGPCLSGSLVSLHCLACGKSLKTPRVVGVEEASVDSWPWQVSIQYDK", "length": 173, "header": "tr|E5RIH1-1|TMPS4_HUMAN Computationally mapped isoform of Transmembrane protease serine 4 OS=Homo sapiens OX=9606 GN=TMPRSS4 PE=1 SV=1 CANONICAL=Q9NRS4-1" }, "locus": { "chromosome": "11", "start_pos": 118111835, "end_pos": 118077303, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000522151.5", "url": "https://www.ensembl.org/id/ENST00000522151.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000428407.1", "url": "https://www.ensembl.org/id/ENSP00000428407.1" } ] } }, { "isoform_ac": "E5RJR8-1", "url": "", "sequence": { "sequence": "MDPDSDQPLNSLGKFRCQTPAQTPYPHGDLQKGGDPHHHSTTEPGEYHHCGCPHQGDSG", "length": 59, "header": "tr|E5RJR8-1|E5RJR8_HUMAN Computationally mapped isoform of Transmembrane serine protease 4 OS=Homo sapiens OX=9606 GN=TMPRSS4 PE=4 SV=1 CANONICAL=Q9NRS4-1" }, "locus": { "chromosome": "11", "start_pos": 118103116, "end_pos": 118077303, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000517483.5", "url": "https://www.ensembl.org/id/ENST00000517483.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000431062.1", "url": "https://www.ensembl.org/id/ENSP00000431062.1" } ] } }, { "isoform_ac": "E7ESG9-1", "url": "", "sequence": { "sequence": "MGYSRAVEIGPDQDLDVVEITENSQELRMRNSSGPCLSGSLVSLHCLACGKSLKTPRVVGVEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWIYNVWKAEL", "length": 290, "header": "tr|E7ESG9-1|E7ESG9_HUMAN Computationally mapped isoform of Transmembrane serine protease 4 OS=Homo sapiens OX=9606 GN=TMPRSS4 PE=1 SV=1 CANONICAL=Q9NRS4-1" }, "locus": { "chromosome": "11", "start_pos": 118117910, "end_pos": 118104807, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000522307.5", "url": "https://www.ensembl.org/id/ENST00000522307.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000428814.1", "url": "https://www.ensembl.org/id/ENSP00000428814.1" } ] } }, { "isoform_ac": "G3V124-1", "url": "", "sequence": { "sequence": "MDPDSDQPLNSLDVKPLRKPRIPMETFRKVGIPIIIALLSLASIIIVVVLIKVILDKYYFLCGQPLHFIPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALAETACRQMGYSSKPTFRAVEIGPDQDLDVVEITENSQELRMRNSSGPCLSGSLVSLHCLACGKSLKTPRVVGVEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGG", "length": 335, "header": "tr|G3V124-1|G3V124_HUMAN Computationally mapped isoform of Transmembrane protease, serine 4, isoform CRA_c OS=Homo sapiens OX=9606 GN=TMPRSS4 PE=1 SV=1 CANONICAL=Q9NRS4-1" }, "locus": { "chromosome": "11", "start_pos": 118117306, "end_pos": 118077303, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000519236.5", "url": "https://www.ensembl.org/id/ENST00000519236.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000429889.1", "url": "https://www.ensembl.org/id/ENSP00000429889.1" } ] } }, { "isoform_ac": "H0YAX8-1", "url": "", "sequence": { "sequence": "XKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSAYLNWIYNVWKAEL", "length": 62, "header": "tr|H0YAX8-1|H0YAX8_HUMAN Computationally mapped isoform of Transmembrane serine protease 4 OS=Homo sapiens OX=9606 GN=TMPRSS4 PE=1 SV=1 CANONICAL=Q9NRS4-1" }, "locus": { "chromosome": "11", "start_pos": 118117911, "end_pos": 118113292, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000524218.1", "url": "https://www.ensembl.org/id/ENST00000524218.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000428246.1", "url": "https://www.ensembl.org/id/ENSP00000428246.1" } ] } }, { "isoform_ac": "H0YBM5-1", "url": "", "sequence": { "sequence": "XPIIIALLSLASIIIVVVLIKVILDKYYFLCGQPLHFIPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALAETACRQMGYSSKPTFRAVEIGPDQDLDVVEITENSQELRMRNSSG", "length": 148, "header": "tr|H0YBM5-1|H0YBM5_HUMAN Computationally mapped isoform of Transmembrane serine protease 4 OS=Homo sapiens OX=9606 GN=TMPRSS4 PE=1 SV=1 CANONICAL=Q9NRS4-1" }, "locus": { "chromosome": "11", "start_pos": 118107878, "end_pos": 118099043, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000517544.1", "url": "https://www.ensembl.org/id/ENST00000517544.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000429833.1", "url": "https://www.ensembl.org/id/ENSP00000429833.1" } ] } }, { "isoform_ac": "Q9NRS4-1", "url": "", "sequence": { "sequence": "MLQDPDSDQPLNSLDVKPLRKPRIPMETFRKVGIPIIIALLSLASIIIVVVLIKVILDKYYFLCGQPLHFIPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALAETACRQMGYSSKPTFRAVEIGPDQDLDVVEITENSQELRMRNSSGPCLSGSLVSLHCLACGKSLKTPRVVGVEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWIYNVWKAEL", "length": 437, "header": "sp|Q9NRS4-1|TMPS4_HUMAN Isoform 1 of Transmembrane protease serine 4 OS=Homo sapiens OX=9606 GN=TMPRSS4 PE=1 SV=2 CANONICAL=Q9NRS4-1" }, "locus": { "chromosome": "11", "start_pos": 118117910, "end_pos": 118077303, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000437212.8", "url": "https://www.ensembl.org/id/ENST00000437212.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000416037.3", "url": "https://www.ensembl.org/id/ENSP00000416037.3" } ] } }, { "isoform_ac": "Q9NRS4-2", "url": "", "sequence": { "sequence": "MLQDPDSDQPLNSLDVKPLRKPRIPMETFRKVGIPIIIALLSLASIIIVVVLIKVILDKYYFLCGQPLHFIPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALAETACRQMGYSRAVEIGPDQDLDVVEITENSQELRMRNSSGPCLSGSLVSLHCLACGKSLKTPRVVGVEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWIYNVWKAEL", "length": 432, "header": "sp|Q9NRS4-2|TMPS4_HUMAN Isoform 2 of Transmembrane protease serine 4 OS=Homo sapiens OX=9606 GN=TMPRSS4 PE=1 SV=2 CANONICAL=Q9NRS4-1" }, "locus": { "chromosome": "11", "start_pos": 118117910, "end_pos": 118077303, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000522824.5", "url": "https://www.ensembl.org/id/ENST00000522824.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000430547.1", "url": "https://www.ensembl.org/id/ENSP00000430547.1" } ] } }, { "isoform_ac": "Q9NRS4-3", "url": "", "sequence": { "sequence": "MDPDSDQPLNSLDVKPLRKPRIPMETFRKVGIPIIIALLSLASIIIVVVLIKVILDKYYFLCGQPLHFIPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALAETACRQMGYSSKPTFRAVEIGPDQDLDVVEITENSQELRMRNSSGPCLSGSLVSLHCLACGKSLKTPRVVGVEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWIYNVWKAEL", "length": 435, "header": "sp|Q9NRS4-3|TMPS4_HUMAN Isoform 3 of Transmembrane protease serine 4 OS=Homo sapiens OX=9606 GN=TMPRSS4 PE=1 SV=2 CANONICAL=Q9NRS4-1" }, "locus": { "chromosome": "11", "start_pos": 118117910, "end_pos": 118077303, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000534111.5", "url": "https://www.ensembl.org/id/ENST00000534111.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000435184.1", "url": "https://www.ensembl.org/id/ENSP00000435184.1" } ] } }, { "isoform_ac": "Q9NRS4-4", "url": "", "sequence": { "sequence": "MDPDSDQPLNSLVKVILDKYYFLCGQPLHFIPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALAETACRQMGYSSKPTFRAVEIGPDQDLDVVEITENSQELRMRNSSGPCLSGSLVSLHCLACGKSLKTPRVVGVEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWIYNVWKAEL", "length": 397, "header": "sp|Q9NRS4-4|TMPS4_HUMAN Isoform 4 of Transmembrane protease serine 4 OS=Homo sapiens OX=9606 GN=TMPRSS4 PE=1 SV=2 CANONICAL=Q9NRS4-1" }, "locus": { "chromosome": "11", "start_pos": 118117910, "end_pos": 118077303, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000523251.5", "url": "https://www.ensembl.org/id/ENST00000523251.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000429209.1", "url": "https://www.ensembl.org/id/ENSP00000429209.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 130, "start_aa": "Asn", "end_pos": 130, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn130", "evidence": [ { "id": "Q9NRS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NRS4#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 178, "start_aa": "Asn", "end_pos": 178, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn178", "evidence": [ { "id": "Q9NRS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NRS4#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "A novel transmembrane serine protease (TMPRSS3) overexpressed in pancreatic cancer.", "journal": "Cancer Res.", "date": "2000", "authors": "Gress T.M., Wallrapp C., Adler G., Mueller-Pillasch F., Iwamura T., Lerch M.M., Burghardt B., Haehnel S., Ruthenbuerger M.", "evidence": [ { "database": "UniProtKB", "id": "Q9NRS4", "url": "https://www.uniprot.org/uniprot/Q9NRS4" } ], "reference": [ { "type": "PubMed", "id": "10825129", "url": "https://glygen.org/publication/PubMed/10825129" } ] }, { "title": "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.", "journal": "Genome Res.", "date": "2003", "authors": "Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A", "evidence": [ { "database": "UniProtKB", "id": "Q9NRS4", "url": "https://www.uniprot.org/uniprot/Q9NRS4" } ], "reference": [ { "type": "PubMed", "id": "12975309", "url": "https://glygen.org/publication/PubMed/12975309" } ] }, { "title": "ECM1 and TMPRSS4 are diagnostic markers of malignant thyroid neoplasms and improve the accuracy of fine needle aspiration biopsy.", "journal": "Annals of surgery", "date": "2005", "authors": "Kebebew E, Peng M, Reiff E, Duh QY, Clark OH, McMillan A", "evidence": [ { "database": "GlyGen", "id": "A0469", "url": "https://data.glygen.org/GLY_000625" } ], "reference": [ { "type": "PubMed", "id": "16135921", "url": "https://glygen.org/publication/PubMed/16135921" } ] }, { "title": "TMPRSS4 promotes invasion, migration and metastasis of human tumor cells by facilitating an epithelial-mesenchymal transition.", "journal": "Oncogene", "date": "2008", "authors": "Jung H, Lee KP, Park SJ, Park JH, Jang YS, Choi SY, Jung JG, Jo K, Park DY, Yoon JH, Park JH, Lim DS, Hong GR, Choi C, Park YK, Lee JW, Hong HJ, Kim S, Park YW", "evidence": [ { "database": "RefSeq", "id": "NP_001077416", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077416" } ], "reference": [ { "type": "PubMed", "id": "17968309", "url": "https://glygen.org/publication/PubMed/17968309" } ] }, { "title": "Proteolytic activation of the 1918 influenza virus hemagglutinin.", "journal": "Journal of virology", "date": "2009", "authors": "Chaipan C, Kobasa D, Bertram S, Glowacka I, Steffen I, Tsegaye TS, Takeda M, Bugge TH, Kim S, Park Y, Marzi A, Pohlmann S", "evidence": [ { "database": "RefSeq", "id": "NP_001077416", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077416" } ], "reference": [ { "type": "PubMed", "id": "19158246", "url": "https://glygen.org/publication/PubMed/19158246" } ] }, { "title": "TMPRSS4 induces invasion and epithelial-mesenchymal transition through upregulation of integrin alpha5 and its signaling pathways.", "journal": "Carcinogenesis", "date": "2010", "authors": "Kim S, Kang HY, Nam EH, Choi MS, Zhao XF, Hong CS, Lee JW, Lee JH, Park YK", "evidence": [ { "database": "RefSeq", "id": "NP_001077416", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077416" } ], "reference": [ { "type": "PubMed", "id": "20118200", "url": "https://glygen.org/publication/PubMed/20118200" } ] }, { "title": "TMPRSS2 and TMPRSS4 facilitate trypsin-independent spread of influenza virus in Caco-2 cells.", "journal": "Journal of virology", "date": "2010", "authors": "Bertram S, Glowacka I, Blazejewska P, Soilleux E, Allen P, Danisch S, Steffen I, Choi SY, Park Y, Schneider H, Schughart K, Pohlmann S", "evidence": [ { "database": "RefSeq", "id": "NP_001077416", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077416" } ], "reference": [ { "type": "PubMed", "id": "20631123", "url": "https://glygen.org/publication/PubMed/20631123" } ] }, { "title": "TMPRSS4 induces cancer cell invasion through pro-uPA processing.", "journal": "Biochem. Biophys. Res. Commun.", "date": "2014", "authors": "Min HJ, Lee MK, Lee JW, Kim S", "evidence": [ { "database": "UniProtKB", "id": "Q9NRS4", "url": "https://www.uniprot.org/uniprot/Q9NRS4" } ], "reference": [ { "type": "PubMed", "id": "24434139", "url": "https://glygen.org/publication/PubMed/24434139" } ] }, { "title": "TMPRSS4: an emerging potential therapeutic target in cancer.", "journal": "Br. J. Cancer", "date": "2015", "authors": "de Aberasturi AL, Calvo A", "evidence": [ { "database": "UniProtKB", "id": "Q9NRS4", "url": "https://www.uniprot.org/uniprot/Q9NRS4" } ], "reference": [ { "type": "PubMed", "id": "25203520", "url": "https://glygen.org/publication/PubMed/25203520" } ] }, { "title": "Transmembrane Protease TMPRSS4 Promotes the Formation and Development of Mismatch Repair Deficient Colon Cancer Liver Metastasis.", "journal": "Bulletin of experimental biology and medicine", "date": "2021", "authors": "Yang YS, Wen D, Zhao XF", "evidence": [ { "database": "RefSeq", "id": "NP_001077416", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077416" } ], "reference": [ { "type": "PubMed", "id": "34173918", "url": "https://glygen.org/publication/PubMed/34173918" } ] }, { "title": "Utility of TMPRSS4 as a Prognostic Biomarker and Potential Therapeutic Target in Patients with Gastric Cancer.", "journal": "Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract", "date": "2022", "authors": "Tazawa H, Suzuki T, Saito A, Ishikawa A, Komo T, Sada H, Shimada N, Hadano N, Onoe T, Sudo T, Shimizu Y, Kuraoka K, Tashiro H", "evidence": [ { "database": "RefSeq", "id": "NP_001077416", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077416" } ], "reference": [ { "type": "PubMed", "id": "34379296", "url": "https://glygen.org/publication/PubMed/34379296" } ] }, { "title": "TMPRSS4 overexpression promotes the metastasis of colorectal cancer and predicts poor prognosis of stage III-IV colorectal cancer.", "journal": "The International journal of biological markers", "date": "2021", "authors": "Zhao XF, Yang YS, Gao DZ, Park YK", "evidence": [ { "database": "RefSeq", "id": "NP_001077416", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077416" } ], "reference": [ { "type": "PubMed", "id": "34595980", "url": "https://glygen.org/publication/PubMed/34595980" } ] }, { "title": "Increased TRIM31 gene expression is positively 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