{ "uniprot_canonical_ac": "Q9JKZ2-1", "uniprot_ac": "Q9JKZ2", "uniprot_id": "SC5A3_MOUSE", "mass": { "chemical_mass": 79583.0, "monoisotopic_mass": 79583.0 }, "refseq": { "ac": "NP_059087", "name": "sodium/myo-inositol cotransporter", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059087" }, "gene_names": [ { "name": "Slc5a3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q9JKZ2", "id": "Q9JKZ2" }, { "name": "Slc5a3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059087", "id": "NP_059087" }, { "name": "Smit1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059087", "id": "NP_059087" } ], "protein_names": [ { "name": "Sodium/myo-inositol cotransporter", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q9JKZ2" }, { "name": "Na(+)/myo-inositol cotransporter", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9JKZ2" }, { "name": "SMIT1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9JKZ2" }, { "name": "Sodium/myo-inositol transporter 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9JKZ2" }, { "name": "Solute carrier family 5 member 3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9JKZ2" }, { "name": "sodium/myo-inositol cotransporter", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059087", "id": "NP_059087" }, { "name": "solute carrier family 5, member 3; solute carrier family 5, member alpha 3; sodium myo-inositol transporter 1; Na(+)/myo-inositol cotransporter", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059087", "id": "NP_059087" } ], "function": [ { "annotation": "(Microbial infection) Functions as a retroviral receptor for M813 murine leukemia virus (MuLV) entry.", "evidence": [ { "database": "UniProtKB", "id": "Q9JKZ2", "url": "https://www.uniprot.org/uniprot/Q9JKZ2#function" }, { "database": "PubMed", "id": "12719585", "url": "https://glygen.org/publication/PubMed/12719585" } ] }, { "annotation": "Electrogenic Na(+)-coupled sugar symporter that actively transports myo-inositol and its stereoisomer scyllo-inositol across the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1 (By similarity). Maintains myo-inositol concentration gradient that defines cell volume and fluid balance during osmotic stress, in particular in the fetoplacental unit and central nervous system (PubMed:12582158, PubMed:24595108). Forms coregulatory complexes with voltage-gated K(+) ion channels, allosterically altering ion selectivity, voltage dependence and gating kinetics of the channel. In turn, K(+) efflux through the channel forms a local electrical gradient that modulates electrogenic Na(+)-coupled myo-inositol influx through the transporter (PubMed:24595108) (By similarity). Associates with KCNQ1-KCNE2 channel in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability (PubMed:24595108). Associates with KCNQ2-KCNQ3 channel altering ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) permeation (By similarity). Provides myo-inositol precursor for biosynthesis of phosphoinositides such as PI(4,5)P2, thus indirectly affecting the activity of phosphoinositide-dependent ion channels and Ca(2+) signaling upon osmotic stress (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q9JKZ2", "url": "https://www.uniprot.org/uniprot/Q9JKZ2#function" }, { "database": "UniProtKB", "id": "P53794", "url": "https://www.uniprot.org/uniprot/P53794#function" }, { "database": "PubMed", "id": "12582158", "url": "https://glygen.org/publication/PubMed/12582158" }, { "database": "UniProtKB", "id": "P31637", "url": "https://www.uniprot.org/uniprot/P31637#function" }, { "database": "PubMed", "id": "24595108", "url": "https://glygen.org/publication/PubMed/24595108" } ] }, { "annotation": "KCNQ1, KCNE2, and SMIT1 form reciprocally regulating complexes that affect neuronal excitability. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_059087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059087" }, { "database": "PubMed", "id": "24595108", "url": "https://glygen.org/publication/PubMed/24595108" } ] }, { "annotation": "Lithium affects the phosphatidylinositol signaling system in two ways: depleting inositol, consequently decreasing phosphoinositides; elevating inositol monophosphate levels followed by phosphoinositols accumulation. Each or both may mediate lithium-induced behavior Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_059087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059087" }, { "database": "PubMed", "id": "27922641", "url": "https://glygen.org/publication/PubMed/27922641" } ] }, { "annotation": "SMIT1 overexpression contributes to abnormal cholinergic and glutamatergic Ca(2+) signals in the trisomic condition", "evidence": [ { "database": "RefSeq", "id": "NP_059087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059087" }, { "database": "PubMed", "id": "28695546", "url": "https://glygen.org/publication/PubMed/28695546" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs3407201763", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs3407201763" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 447, "end_pos": 447, "sequence_org": "Y", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (YLT->NLT).", "chr_id": "16", "chr_pos": "91875283", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "Y447", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs3389375523", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs3389375523" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 549, "end_pos": 549, "sequence_org": "K", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (KKT->NKT).", "chr_id": "16", "chr_pos": "91875591", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "K549", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q9JKZ2", "url": "https://www.uniprot.org/uniprot/Q9JKZ2" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Slc5a3", "url": "https://www.uniprot.org/uniprot/Q9JKZ2", "locus": { "chromosome": "16", "start_pos": 91884361, "end_pos": 91855210, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000089774", "url": "https://www.ensembl.org/id/ENSMUSG00000089774" } ] } } ], "crossref": [ { "id": "ENSMUSG00000089774", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000089774", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd11491", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11491", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "53881", "url": "https://www.ncbi.nlm.nih.gov/gene/53881", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "GPDB0007594", "url": "https://acgg.asia/db/gpdb/symbol/GPDB0007594", "database": "GlycoProtDB", "categories": [ "Glycoproteomics" ] }, { "id": "IPR001734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018212", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018212", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038377", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038377", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042731", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042731", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:53881", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:53881", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1858226", "url": "http://www.informatics.jax.org/marker/MGI:1858226", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "IHFMYVA", "url": "https://omabrowser.org/oma/group/IHFMYVA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "74094at2759", "url": "http://www.orthodb.org/?query=74094at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11819", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11819", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11819:SF150", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11819:SF150", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00474", "url": "http://pfam.xfam.org/family/PF00474", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q9JKZ2", "url": "http://purl.obolibrary.org/obo/PR_Q9JKZ2", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-429593", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-429593", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_059087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059087", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "72987", "url": "https://www.rhea-db.org/rhea/72987", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "72991", "url": "https://www.rhea-db.org/rhea/72991", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q9JKZ2", "url": "https://www.uniprot.org/uniprot/Q9JKZ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9JKZ2-1", "url": "https://www.uniprot.org/uniprot/Q9JKZ2-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRAVLEAADIAVVALYFILVMCIGFFAMWKSNRSTVSGYFLAGRSMTWVAIGASLFVSNIGSEHFIGLAGSGAASGFAVGAWEFNALLLLQLLGWVFIPIYIRSGVYTMPEYLSKRFGGHRIQVYFAALSLLLYIFTKLSVDLYSGALFIQESLGWNLYVSVILLIGMTALLTVTGGLVAVIYTDTLQALLMIIGALTLMVISMVKIGGFEEVKRRYMLASPDVASILLKYNLSNTNACMVHPKANALKMLRDPTDEDVPWPGFILGQTPASVWYWCADQVIVQRVLAAKNIAHAKGSTLMAGFLKLLPMFIIVVPGMISRIVFADEIACINPEHCMQVCGSRAGCSNIAYPRLVMTLVPVGLRGLMMAVMIAALMSDLDSIFNSASTIFTLDVYKLIRKSASSRELMIVGRIFVAFMVVISIAWVPIIVEMQGGQMYLYIQEVADYLTPPVAALFLLAIFWKRCNEQGAFYGGMAGFVLGAVRLILAFTYRAPECDQPDNRPGFIKDIHYMYVATALFWITGLITVIVSLLTPPPTKDQIRTTTFWSKKTLVTKESCSQKDEPYKMQEKSILQCSENSEVISHTIPNGKSEDSIKGLQPEDVNLLVTCREEGNPVASMGHSEAETPVDAYSNGQAALMGEREREKETENRSRYWKFIDWFCGFKSKSLSKRSLRDLMDEEAVCLQMLEETPQVKVILNIGLFAVCSLGIFMFVYFSL", "length": 718, "header": "sp|Q9JKZ2-1|SC5A3_MOUSE Isoform 1 of Sodium/myo-inositol cotransporter OS=Mus musculus OX=10090 GN=Slc5a3 PE=1 SV=2 CANONICAL=Q9JKZ2-1" }, "isoforms": [ { "isoform_ac": "Q9JKZ2-1", "url": "", "sequence": { "sequence": "MRAVLEAADIAVVALYFILVMCIGFFAMWKSNRSTVSGYFLAGRSMTWVAIGASLFVSNIGSEHFIGLAGSGAASGFAVGAWEFNALLLLQLLGWVFIPIYIRSGVYTMPEYLSKRFGGHRIQVYFAALSLLLYIFTKLSVDLYSGALFIQESLGWNLYVSVILLIGMTALLTVTGGLVAVIYTDTLQALLMIIGALTLMVISMVKIGGFEEVKRRYMLASPDVASILLKYNLSNTNACMVHPKANALKMLRDPTDEDVPWPGFILGQTPASVWYWCADQVIVQRVLAAKNIAHAKGSTLMAGFLKLLPMFIIVVPGMISRIVFADEIACINPEHCMQVCGSRAGCSNIAYPRLVMTLVPVGLRGLMMAVMIAALMSDLDSIFNSASTIFTLDVYKLIRKSASSRELMIVGRIFVAFMVVISIAWVPIIVEMQGGQMYLYIQEVADYLTPPVAALFLLAIFWKRCNEQGAFYGGMAGFVLGAVRLILAFTYRAPECDQPDNRPGFIKDIHYMYVATALFWITGLITVIVSLLTPPPTKDQIRTTTFWSKKTLVTKESCSQKDEPYKMQEKSILQCSENSEVISHTIPNGKSEDSIKGLQPEDVNLLVTCREEGNPVASMGHSEAETPVDAYSNGQAALMGEREREKETENRSRYWKFIDWFCGFKSKSLSKRSLRDLMDEEAVCLQMLEETPQVKVILNIGLFAVCSLGIFMFVYFSL", "length": 718, "header": "sp|Q9JKZ2-1|SC5A3_MOUSE Isoform 1 of Sodium/myo-inositol cotransporter OS=Mus musculus OX=10090 GN=Slc5a3 PE=1 SV=2 CANONICAL=Q9JKZ2-1" }, "locus": { "chromosome": "16", "start_pos": 91876098, "end_pos": 91873945, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000113975", "url": "https://www.ensembl.org/id/ENSMUST00000113975" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000109608", "url": "https://www.ensembl.org/id/ENSMUSP00000109608" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 232, "start_aa": "Asn", "end_pos": 232, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn232", "evidence": [ { "id": "Q9JKZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JKZ2#ptm_processing" } ] } ], "phosphorylation": [ { "start_pos": 594, "end_pos": 594, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9JKZ2", "url": "https://www.uniprot.org/uniprot/Q9JKZ2" } ], "site_lbl": "Ser594" }, { "start_pos": 618, "end_pos": 618, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "Q9JKZ2", "url": "http://phospho.elm.eu.org/byAccession/Q9JKZ2.html" }, { "database": "iPTMnet", "id": "Q9JKZ2", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9JKZ2" }, { "database": "PubMed", "id": "19144319", "url": "https://glygen.org/publication/PubMed/19144319" } ], "site_lbl": "Ser618" }, { "start_pos": 632, "end_pos": 632, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9JKZ2", "url": "https://www.uniprot.org/uniprot/Q9JKZ2" }, { "database": "phospho.ELM", "id": "Q9JKZ2", "url": "http://phospho.elm.eu.org/byAccession/Q9JKZ2.html" }, { "database": "iPTMnet", "id": "Q9JKZ2", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9JKZ2" }, { "database": "PubMed", "id": "19144319", "url": "https://glygen.org/publication/PubMed/19144319" } ], "site_lbl": "Ser632" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Murine chromosome 16 telomeric region, homologous with human chromosome 21q22, contains the osmoregulatory Na(+)/myo-inositol cotransporter (SLC5A3) gene.", "journal": "Cytogenet. Cell Genet.", "date": "2000", "authors": "Wu S., Berry G.T., Barnoski B.L., Mallee J.J., Lucente A., McVeigh K.E.", "evidence": [ { "database": "UniProtKB", "id": "Q9JKZ2", "url": "https://www.uniprot.org/uniprot/Q9JKZ2" } ], "reference": [ { "type": "PubMed", "id": "10773690", "url": "https://glygen.org/publication/PubMed/10773690" } ] }, { "title": "Loss of murine Na+/myo-inositol cotransporter leads to brain myo-inositol depletion and central apnea.", "journal": "J. Biol. Chem.", "date": "2003", "authors": "Wu S., Ren J., Berry G.T., Golden J.A., Greer J.J., Ballard P.L., Gonzales L.W., Buccafusca R., Stevens M.J.", "evidence": [ { "database": "UniProtKB", "id": "Q9JKZ2", "url": "https://www.uniprot.org/uniprot/Q9JKZ2" } ], "reference": [ { "type": "PubMed", "id": "12582158", "url": "https://glygen.org/publication/PubMed/12582158" } ] }, { "title": "Sodium-dependent myo-inositol transporter 1 is a cellular receptor for Mus cervicolor M813 murine leukemia virus.", "journal": "J. Virol.", "date": "2003", "authors": "Zhang Y., Ivanov D., Prassolov V., Ross S.R., Stocking C., Hein S., Lohler J.", "evidence": [ { "database": "UniProtKB", "id": "Q9JKZ2", "url": "https://www.uniprot.org/uniprot/Q9JKZ2" } ], "reference": [ { "type": "PubMed", "id": "12719585", "url": "https://glygen.org/publication/PubMed/12719585" } ] }, { "title": "The phagosomal proteome in interferon-gamma-activated macrophages.", "journal": "Immunity", "date": "2009", "authors": "Trost M, English L, Lemieux S, Courcelles M, Desjardins M, Thibault P", "evidence": [ { "database": "UniProtKB", "id": "Q9JKZ2", "url": "https://www.uniprot.org/uniprot/Q9JKZ2" }, { "database": "iPTMnet", "id": "Q9JKZ2", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9JKZ2" } ], "reference": [ { "type": "PubMed", "id": "19144319", "url": "https://glygen.org/publication/PubMed/19144319" } ] }, { "title": "KCNQ1, KCNE2, and Na+-coupled solute transporters form reciprocally regulating complexes that affect neuronal excitability.", "journal": "Sci. Signal.", "date": "2014", "authors": "Abbott GW, Tai KK, Neverisky DL, Hansler A, Hu Z, Roepke TK, Lerner DJ, Chen Q, Liu L, Zupan B, Toth M, Haynes R, Huang X, Demirbas D, Buccafusca R, Gross SS, Kanda VA, Berry GT", "evidence": [ { "database": "UniProtKB", "id": "Q9JKZ2", "url": "https://www.uniprot.org/uniprot/Q9JKZ2" }, { "database": "RefSeq", "id": "NP_059087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059087" } ], "reference": [ { "type": "PubMed", "id": "24595108", "url": "https://glygen.org/publication/PubMed/24595108" } ] }, { "title": "IP3 accumulation and/or inositol depletion: two downstream lithium's effects that may mediate its behavioral and cellular changes.", "journal": "Translational psychiatry", "date": "2016", "authors": "Sade Y, Toker L, Kara NZ, Einat H, Rapoport S, Moechars D, Berry GT, Bersudsky Y, Agam G", "evidence": [ { "database": "RefSeq", "id": "NP_059087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059087" } ], "reference": [ { "type": "PubMed", "id": "27922641", "url": "https://glygen.org/publication/PubMed/27922641" } ] }, { "title": "Knockdown of Myo-Inositol Transporter SMIT1 Normalizes Cholinergic and Glutamatergic Function in an Immortalized Cell Line Established from the Cerebral Cortex of a Trisomy 16 Fetal Mouse, an Animal Model of Human Trisomy 21 (Down Syndrome).", "journal": "Neurotoxicity research", "date": "2017", "authors": "Cardenas AM, Fernandez-Olivares P, Diaz-Franulic I, Gonzalez-Jamett AM, Shimahara T, Segura-Aguilar J, Caviedes R, Caviedes P", "evidence": [ { "database": "RefSeq", "id": "NP_059087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059087" } ], "reference": [ { "type": "PubMed", "id": "28695546", "url": "https://glygen.org/publication/PubMed/28695546" } ] } ], "pathway": [ { "id": "mmu:53881", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:53881", "resource": "KEGG Pathway" }, { "id": "R-MMU-429593", "name": "Inositol transporters", "url": 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regulation of reactive oxygen species biosynthetic process", "id": "GO:1903428", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903428", "evidence": [ { "database": "UniProtKB", "id": "Q9JKZ2", "url": "https://www.uniprot.org/uniprot/Q9JKZ2" } ], "pmid": "" }, { "name": "regulation of respiratory gaseous exchange", "id": "GO:0043576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043576", "evidence": [ { "database": "UniProtKB", "id": "Q9JKZ2", "url": "https://www.uniprot.org/uniprot/Q9JKZ2" } ], "pmid": "" }, { "name": "myo-inositol transport", "id": "GO:0015798", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015798", "evidence": [ { "database": "UniProtKB", "id": "Q9JKZ2", "url": "https://www.uniprot.org/uniprot/Q9JKZ2" } ], "pmid": "" }, { "name": "positive regulation of protein localization to membrane", "id": "GO:1905477", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905477", "evidence": [ { "database": "UniProtKB", "id": "Q9JKZ2", "url": 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