{ "uniprot_canonical_ac": "Q9JJH7-1", "uniprot_ac": "Q9JJH7", "uniprot_id": "TRPM5_MOUSE", "mass": { "chemical_mass": 130844.0, "monoisotopic_mass": 130844.0 }, "refseq": { "ac": "NP_064673", "name": "transient receptor potential cation channel subfamily M member 5", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064673" }, "gene_names": [ { "name": "Trpm5", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q9JJH7", "id": "Q9JJH7" }, { "name": "9430099A16Rik; LTrpC-5; Ltrpc5; Mtr1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064673", "id": "NP_064673" }, { "name": "Ltrpc5", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9JJH7", "id": "Q9JJH7" }, { "name": "Mtr1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9JJH7", "id": "Q9JJH7" }, { "name": "Trpm5", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064673", "id": "NP_064673" } ], "protein_names": [ { "name": "Transient receptor potential cation channel subfamily M member 5", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q9JJH7" }, { "name": "LTrpC-5", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9JJH7" }, { "name": "LTrpC5", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9JJH7" }, { "name": "Long transient receptor potential channel 5", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9JJH7" }, { "name": "MLSN1- and TRP-related gene 1 protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9JJH7" }, { "name": "long transient receptor potential-related channel 5; MLSN1- and TRP-related gene 1 protein; long transient receptor potential channel 5", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064673", "id": "NP_064673" }, { "name": "transient receptor potential cation channel subfamily M member 5", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064673", "id": "NP_064673" } ], "function": [ { "annotation": "Fat preference deficits and experience-induced recovery in global taste-deficient Trpm5 and Calhm1 knockout mice.", "evidence": [ { "database": "RefSeq", "id": "NP_064673", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064673" }, { "database": "PubMed", "id": "34998826", "url": "https://glygen.org/publication/PubMed/34998826" } ] }, { "annotation": "Trpm5 channels encode bistability of spinal motoneurons and ensure motor control of hindlimbs in mice. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_064673", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064673" }, { "database": "PubMed", "id": "34819493", "url": "https://glygen.org/publication/PubMed/34819493" } ] }, { "annotation": "Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent-specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). Also activated by a fast intracellular Ca(2+) increase in response to inositol 1,4,5-triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. Heat activation is due to a shift of the voltage-dependent activation curve to negative potentials. Activated by arachidonic acid in vitro. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals.", "evidence": [ { "database": "UniProtKB", "id": "Q9JJH7", "url": "https://www.uniprot.org/uniprot/Q9JJH7#function" }, { "database": "PubMed", "id": "14657398", "url": "https://glygen.org/publication/PubMed/14657398" }, { "database": "PubMed", "id": "17267604", "url": "https://glygen.org/publication/PubMed/17267604" }, { "database": "PubMed", "id": "16355226", "url": "https://glygen.org/publication/PubMed/16355226" }, { "database": "PubMed", "id": "16935556", "url": "https://glygen.org/publication/PubMed/16935556" }, { "database": "PubMed", "id": "16436689", "url": "https://glygen.org/publication/PubMed/16436689" }, { "database": "PubMed", "id": "15731110", "url": "https://glygen.org/publication/PubMed/15731110" }, { "database": "PubMed", "id": "12842017", "url": "https://glygen.org/publication/PubMed/12842017" }, { "database": "PubMed", "id": "17522321", "url": "https://glygen.org/publication/PubMed/17522321" } ] } ], "disease": [], "snv": [], "mutagenesis": [ { "start_pos": 831, "end_pos": 831, "sequence_org": "E", "sequence_mut": "Q", "comment": "Reduces sensitivity to block by extracellular acidification. Sensitivity to block by low extracellular pH is nearly abolished; when associated with N-935.", "evidence": [ { "database": "UniProtKB", "id": "Q9JJH7", "url": "https://www.uniprot.org/uniprot/Q9JJH7" }, { "database": "PubMed", "id": "15731110", "url": "https://glygen.org/publication/PubMed/15731110" } ] }, { "start_pos": 897, "end_pos": 897, "sequence_org": "H", "sequence_mut": "N", "comment": "Shows normal sensitivity to acid block and significant recovery from acid-enhanced inactivation.", "evidence": [ { "database": "UniProtKB", "id": "Q9JJH7", "url": "https://www.uniprot.org/uniprot/Q9JJH7" }, { "database": "PubMed", "id": "15731110", "url": "https://glygen.org/publication/PubMed/15731110" } ] }, { "start_pos": 935, "end_pos": 935, "sequence_org": "H", "sequence_mut": "N", "comment": "Reduces sensitivity to block by extracellular acidification. Sensitivity to block by low extracellular pH is nearly abolished; when associated with Q-831.", "evidence": [ { "database": "UniProtKB", "id": "Q9JJH7", "url": "https://www.uniprot.org/uniprot/Q9JJH7" }, { "database": "PubMed", "id": "15731110", "url": "https://glygen.org/publication/PubMed/15731110" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q9JJH7", "url": "https://www.uniprot.org/uniprot/Q9JJH7" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Trpm5", "url": "https://www.uniprot.org/uniprot/Q9JJH7", "locus": { "chromosome": "7", "start_pos": 142622890, "end_pos": 142648379, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000009246", "url": "https://www.ensembl.org/id/ENSMUSG00000009246" } ] } } ], "crossref": [ { "id": "ENSMUSG00000009246", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000009246", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "CHEMBL3886124", "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL3886124", "database": "ChEMBL", "categories": [ "Other" ] }, { "id": "56843", "url": "https://www.ncbi.nlm.nih.gov/gene/56843", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005821", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005821", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041491", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041491", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:56843", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:56843", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1861718", "url": "http://www.informatics.jax.org/marker/MGI:1861718", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "ICYCTAV", "url": "https://omabrowser.org/oma/group/ICYCTAV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "201873at2759", "url": "http://www.orthodb.org/?query=201873at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13800", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13800", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13800:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13800:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00520", "url": "http://pfam.xfam.org/family/PF00520", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF18139", "url": "http://pfam.xfam.org/family/PF18139", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q9JJH7", "url": "http://purl.obolibrary.org/obo/PR_Q9JJH7", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-3295583", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-3295583", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_064673", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064673", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "F6RUN7", "url": "https://www.uniprot.org/uniprot/F6RUN7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6RUN7-1", "url": "https://www.uniprot.org/uniprot/F6RUN7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F7CCW2", "url": "https://www.uniprot.org/uniprot/F7CCW2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F7CCW2-1", "url": "https://www.uniprot.org/uniprot/F7CCW2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9JJH7", "url": "https://www.uniprot.org/uniprot/Q9JJH7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9JJH7-1", "url": "https://www.uniprot.org/uniprot/Q9JJH7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9JJH7-2", "url": "https://www.uniprot.org/uniprot/Q9JJH7-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9JJH7-3", "url": "https://www.uniprot.org/uniprot/Q9JJH7-3", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQTTQSSCPGSPPDTEDGWEPILCRGEINFGGSGKKRGKFVKVPSSVAPSVLFELLLTEWHLPAPNLVVSLVGEERPLAMKSWLRDVLRKGLVKAAQSTGAWILTSALHVGLARHVGQAVRDHSLASTSTKIRVVAIGMASLDRILHRQLLDGVHQKEDTPIHYPADEGNIQGPLCPLDSNLSHFILVESGALGSGNDGLTELQLSLEKHISQQRTGYGGTSCIQIPVLCLLVNGDPNTLERISRAVEQAAPWLILAGSGGIADVLAALVSQPHLLVPQVAEKQFREKFPSECFSWEAIVHWTELLQNIAAHPHLLTVYDFEQEGSEDLDTVILKALVKACKSHSQEAQDYLDELKLAVAWDRVDIAKSEIFNGDVEWKSCDLEEVMTDALVSNKPDFVRLFVDSGADMAEFLTYGRLQQLYHSVSPKSLLFELLQRKHEEGRLTLAGLGAQQARELPIGLPAFSLHEVSRVLKDFLHDACRGFYQDGRRMEERGPPKRPAGQKWLPDLSRKSEDPWRDLFLWAVLQNRYEMATYFWAMGREGVAAALAACKIIKEMSHLEKEAEVARTMREAKYEQLALDLFSECYGNSEDRAFALLVRRNHSWSRTTCLHLATEADAKAFFAHDGVQAFLTKIWWGDMATGTPILRLLGAFTCPALIYTNLISFSEDAPQRMDLEDLQEPDSLDMEKSFLCSRGGQLEKLTEAPRAPGDLGPQAAFLLTRWRKFWGAPVTVFLGNVVMYFAFLFLFTYVLLVDFRPPPQGPSGSEVTLYFWVFTLVLEEIRQGFFTDEDTHLVKKFTLYVEDNWNKCDMVAIFLFIVGVTCRMVPSVFEAGRTVLAIDFMVFTLRLIHIFAIHKQLGPKIIIVERMMKDVFFFLFFLSVWLVAYGVTTQALLHPHDGRLEWIFRRVLYRPYLQIFGQIPLDEIDEARVNCSLHPLLLESSASCPNLYANWLVILLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYHLIVEYHGRPALAPPFILLSHLSLVLKQVFRKEAQHKRQHLERDLPDPLDQKIITWETVQKENFLSTMEKRRRDSEGEVLRKTAHRVDLIAKYIGGLREQEKRIKCLESQANYCMLLLSSMTDTLAPGGTYSSSQNCGCRSQPASARDREYLESGLPPSDT", "length": 1158, "header": "sp|Q9JJH7-1|TRPM5_MOUSE Isoform 1 of Transient receptor potential cation channel subfamily M member 5 OS=Mus musculus OX=10090 GN=Trpm5 PE=1 SV=1 CANONICAL=Q9JJH7-1" }, "isoforms": [ { "isoform_ac": "F6RUN7-1", "url": "", "sequence": { "sequence": "XKFQRYHLIVEYHGRPALAPPFILLSHLSLVLKQVFRKEAQHKRQHLERDLPDPLDQKIITWETVQKENFLSTMEKRRRDSEGEVLRKTAHRVDLIAKYIGGLREQEKRIKCLESQANYCMLLLSSMTDTLAPGGTYSTSRQFPGIRSCPVSLGFLGNRVSGDQIFVASAPEKLQLPEGNGFPPNVSRDL", "length": 190, "header": "tr|F6RUN7-1|TRPM5_MOUSE Computationally mapped isoform of Transient receptor potential cation channel subfamily M member 5 OS=Mus musculus OX=10090 GN=Trpm5 PE=1 SV=1 CANONICAL=Q9JJH7-1" }, "locus": { "chromosome": "7", "start_pos": 142628298, "end_pos": 142623046, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000148715.8", "url": "https://www.ensembl.org/id/ENSMUST00000148715.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000121802.2", "url": "https://www.ensembl.org/id/ENSMUSP00000121802.2" } ] } }, { "isoform_ac": "F7CCW2-1", "url": "", "sequence": { "sequence": "XFLSTMEKRRRDSEGEVLRKTAHRVDLIAKYIGGLREQEKRIKCLESQANYCMLLLSSMTDTLAPGGTYSTSVE", "length": 74, "header": "tr|F7CCW2-1|F7CCW2_MOUSE Computationally mapped isoform of Transient receptor potential cation channel, subfamily M, member 5 OS=Mus musculus OX=10090 GN=Trpm5 PE=4 SV=1 CANONICAL=Q9JJH7-1" }, "locus": { "chromosome": "7", "start_pos": 142627774, "end_pos": 142625228, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000136602.8", "url": "https://www.ensembl.org/id/ENSMUST00000136602.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000122685.2", "url": "https://www.ensembl.org/id/ENSMUSP00000122685.2" } ] } }, { "isoform_ac": "Q9JJH7-1", "url": "", "sequence": { "sequence": "MQTTQSSCPGSPPDTEDGWEPILCRGEINFGGSGKKRGKFVKVPSSVAPSVLFELLLTEWHLPAPNLVVSLVGEERPLAMKSWLRDVLRKGLVKAAQSTGAWILTSALHVGLARHVGQAVRDHSLASTSTKIRVVAIGMASLDRILHRQLLDGVHQKEDTPIHYPADEGNIQGPLCPLDSNLSHFILVESGALGSGNDGLTELQLSLEKHISQQRTGYGGTSCIQIPVLCLLVNGDPNTLERISRAVEQAAPWLILAGSGGIADVLAALVSQPHLLVPQVAEKQFREKFPSECFSWEAIVHWTELLQNIAAHPHLLTVYDFEQEGSEDLDTVILKALVKACKSHSQEAQDYLDELKLAVAWDRVDIAKSEIFNGDVEWKSCDLEEVMTDALVSNKPDFVRLFVDSGADMAEFLTYGRLQQLYHSVSPKSLLFELLQRKHEEGRLTLAGLGAQQARELPIGLPAFSLHEVSRVLKDFLHDACRGFYQDGRRMEERGPPKRPAGQKWLPDLSRKSEDPWRDLFLWAVLQNRYEMATYFWAMGREGVAAALAACKIIKEMSHLEKEAEVARTMREAKYEQLALDLFSECYGNSEDRAFALLVRRNHSWSRTTCLHLATEADAKAFFAHDGVQAFLTKIWWGDMATGTPILRLLGAFTCPALIYTNLISFSEDAPQRMDLEDLQEPDSLDMEKSFLCSRGGQLEKLTEAPRAPGDLGPQAAFLLTRWRKFWGAPVTVFLGNVVMYFAFLFLFTYVLLVDFRPPPQGPSGSEVTLYFWVFTLVLEEIRQGFFTDEDTHLVKKFTLYVEDNWNKCDMVAIFLFIVGVTCRMVPSVFEAGRTVLAIDFMVFTLRLIHIFAIHKQLGPKIIIVERMMKDVFFFLFFLSVWLVAYGVTTQALLHPHDGRLEWIFRRVLYRPYLQIFGQIPLDEIDEARVNCSLHPLLLESSASCPNLYANWLVILLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYHLIVEYHGRPALAPPFILLSHLSLVLKQVFRKEAQHKRQHLERDLPDPLDQKIITWETVQKENFLSTMEKRRRDSEGEVLRKTAHRVDLIAKYIGGLREQEKRIKCLESQANYCMLLLSSMTDTLAPGGTYSSSQNCGCRSQPASARDREYLESGLPPSDT", "length": 1158, "header": "sp|Q9JJH7-1|TRPM5_MOUSE Isoform 1 of Transient receptor potential cation channel subfamily M member 5 OS=Mus musculus OX=10090 GN=Trpm5 PE=1 SV=1 CANONICAL=Q9JJH7-1" }, "locus": { "chromosome": "7", "start_pos": 142643345, "end_pos": 142626088, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000009390", "url": "https://www.ensembl.org/id/ENSMUST00000009390" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000009390", "url": "https://www.ensembl.org/id/ENSMUSP00000009390" } ] } }, { "isoform_ac": "Q9JJH7-2", "url": "", "sequence": { "sequence": "MQTTQSSCPGSPPDTEDGWEPILCRGEINFGGSGKKRGKFVKVPSSVAPSVLFELLLTEWHLPAPNLVVSLVGEERPLAMKSWLRDVLRKGLVKAAQSTGAWILTSALHVGLARHVGQAVRDHSLASTSTKIRVVAIGMASLDRILHRQLLDGVHQKEDTPIHYPADEGNIQGPLCPLDSNLSHFILVESGALGSGNDGLTELQLSLEKHISQQRTGYGGTSCIQIPVLCLLVNGDPNTLERISRAVEQAAPWLILAGSGGIADVLAALVSQPHLLVPQVAEKQFREKFPSECFSWEAIVHWTELLQNIAAHPHLLTVYDFEQEGSEDLDTVILKALVKACKSHSQEAQDYLDELKLAVAWDRVDIAKSEIFNGDVEWKSCDLEEVMTDALVSNKPDFVRLFVDSGADMAEFLTYGRLQQLYHSVSPKSLLFELLQRKHEEGRLTLAGLGAQQARELPIGLPAFSLHEVSRVLKDFLHDACRGFYQDGRRMEERGPPKRPAGQKWLPDLSRKSEDPWRDLFLWAVLQNRYEMATYFWAMGREGVAAALAACKIIKEMSHLEKEAEVARTMREAKYEQLALDLFSECYGNSEDRAFALLVRRNHSWSRTTCLHLATEADAKAFFAHDGVQAFLTKIWWGDMATGTPILRLLGAFTCPALIYTNLISFSEDAPQRMDLEDLQEPDSLDMEKSFLCSRGGQLEKLTEAPRAPGDLGPQAAFLLTRWRKFWGAPVTVFLGNVVMYFAFLFLFTYVLLVDFRPPPQGPSGSEVTLYFWVFTLVLEEIRQGFFTDEDTHLVKKFTLYVEDNWNKCDMVAIFLFIVGVTCRMVPSVFEAGRTVLAIDFMVFTLRLIHIFAIHKQLGPKIIIVERMMKDVFFFLFFLSVWLVAYGVTTQALLHPHDGRLEWIFRRVLYRPYLQIFGQIPLDEIDEARVNCSLHPLLLESSASCPNLYANWLVILLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYHLIVEYHGRPALAPPFILLSHLSLVLKQVFRKEAQHKRQHLERDLPDPLDQKIITWETVQKENFLSTMEKRRRDSEGEVLRKTAHRVDLIAKYIGGLREQEKRIKCLESQSKYGFRPWE", "length": 1116, "header": "sp|Q9JJH7-2|TRPM5_MOUSE Isoform 2 of Transient receptor potential cation channel subfamily M member 5 OS=Mus musculus OX=10090 GN=Trpm5 PE=1 SV=1 CANONICAL=Q9JJH7-1" }, "locus": {} }, { "isoform_ac": "Q9JJH7-3", "url": "", "sequence": { "sequence": "MQTTQSSCPGSPPDTEDGWEPILCRGEINFGGSGKKRGKFVKVPSSVAPSVLFELLLTEWHLPAPNLVVSLVGEERPLAMKSWLRDVLRKGLVKAAQSTGAWILTSALHVGLARHVGQAVRDHSLASTSTKIRVVAIGMASLDRILHRQLLDGVHQKEDTPIHYPADEGNIQGPLCPLDSNLSHFILVESGALGSGNDGLTELQLSLEKHISQQRTGYGGTSCIQIPVLCLLVNGDPNTLERISRAVEQAAPWLILAGSGGIADVLAALVSQPHLLVPQVAEKQFREKFPSECFSWEAIVHWTELLQNIAAHPHLLTVYDFEQEGSEDLDTVILKALVKACKSHSQEAQDYLDELKLAVAWDRVDIAKSEIFNGDVEWKSCDLEEVMTDALVSNKPDFVRLFVDSGADMAEFLTYGRLQQLYHSVSPKSLLFELLQRKHEEGRLTLAGLGAQQARELPIGLPAFSLHEVSRVLKDFLHDACRGFYQDGRRMEERGPPKRPAGQKWLPDLSRKSEDPWRDLFLWAVLQNRYEMATYFWAMGREGVAAALAACKIIKEMSHLEKEAEVARTMREAKYEQLALDLFSECYGNSEDRAFALLVRRNHSWSRTTCLHLATEADAKAFFAHDGVQAFLTKIWWGDMATGTPILRLLGAFTCPALIYTNLISFSEDAPQRMDLEDLQEPDSLDMEKSFLCSRGGQLEKLTEAPRAPGDLGPQAAFLLTRWRKFWGAPVTVFLGNVVMYFAFLFLFTYVLLVDFRPPPQGPSGSEVTLYFWVFTLVLEEIRQGFFTDEDTHLVKKFTLYVEDNWNKCDMVAIFLFIVGVTCRMVPSVFEAGRTVLAIDFMVFTLRLIHIFAIHKQLGPKIIIVERMMKDVFFFLFFLSVWLVAYGVTTQALLHPHDGRLEWIFRRVLYRPYLQIFGQIPLDEIDEARVNCSLHPLLLESSASCPNLYANWLVILLLVTFLLVTNVLLMNLLIAMFRVLTETGPMSWYFAAVSSGLDLQ", "length": 1000, "header": "sp|Q9JJH7-3|TRPM5_MOUSE Isoform 3 of Transient receptor potential cation channel subfamily M member 5 OS=Mus musculus OX=10090 GN=Trpm5 PE=1 SV=1 CANONICAL=Q9JJH7-1" }, "locus": { "chromosome": "7", "start_pos": 142643345, "end_pos": 142629090, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000150867", "url": "https://www.ensembl.org/id/ENSMUST00000150867" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000114302", "url": "https://www.ensembl.org/id/ENSMUSP00000114302" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Mtr1, a novel biallelically expressed gene in the center of the mouse distal chromosome 7 imprinting cluster, is a member of the Trp gene family.", "journal": "Genomics", "date": "2000", "authors": "Enklaar T, Esswein M, Oswald M, Hilbert K, Winterpacht A, Higgins M, Zabel B, Prawitt D", "evidence": [ { "database": "UniProtKB", "id": "Q9JJH7", "url": "https://www.uniprot.org/uniprot/Q9JJH7" } ], "reference": [ { "type": "PubMed", "id": "10903843", "url": "https://glygen.org/publication/PubMed/10903843" } ] }, { "title": "Sequence-based structural features between Kvlqt1 and Tapa1 on mouse chromosome 7F4/F5 corresponding to the Beckwith-Wiedemann syndrome region on human 11p15.5: long-stretches of unusually well conserved intronic sequences of kvlqt1 between mouse and human.", "journal": "DNA Res.", "date": "2000", "authors": "Hattori M., Nishimura M., Sakaki Y., Sasaki H., Watanabe H., Zhu X., Joh K., Mukai T., Yatsuki H., Higashimoto K., Soejima H., Xin Z., Komoda H., Kuratomi S.", "evidence": [ { "database": "UniProtKB", "id": "Q9JJH7", "url": "https://www.uniprot.org/uniprot/Q9JJH7" } ], "reference": [ { "type": "PubMed", "id": "10907850", "url": "https://glygen.org/publication/PubMed/10907850" } ] }, { "title": "Sequence conservation and variability of imprinting in the Beckwith-Wiedemann syndrome gene cluster in human and mouse.", "journal": "Hum. Mol. Genet.", "date": "2000", "authors": "Paulsen M, El-Maarri O, Engemann S, Strodicke M, Franck O, Davies K, Reinhardt R, Reik W, Walter J", "evidence": [ { "database": "UniProtKB", "id": "Q9JJH7", "url": "https://www.uniprot.org/uniprot/Q9JJH7" } ], "reference": [ { "type": "PubMed", "id": "10915772", "url": "https://glygen.org/publication/PubMed/10915772" } ] }, { "title": "A transient receptor potential channel expressed in taste receptor cells.", "journal": "Nat. Neurosci.", "date": "2002", "authors": "Zhang H., Rong M., Huang L., Margolskee R.F., Max M., Kozak J.A., Perez C.A., Preuss A.K.", "evidence": [ { "database": "UniProtKB", "id": "Q9JJH7", "url": "https://www.uniprot.org/uniprot/Q9JJH7" } ], "reference": [ { "type": "PubMed", "id": "12368808", "url": "https://glygen.org/publication/PubMed/12368808" } ] }, { "title": "TRPM5 is a voltage-modulated and Ca(2+)-activated monovalent selective cation channel.", "journal": "Curr. Biol.", "date": "2003", "authors": "Hofmann T, Chubanov V, Gudermann T, Montell C", "evidence": [ { "database": "UniProtKB", "id": "Q9JJH7", "url": "https://www.uniprot.org/uniprot/Q9JJH7" } ], "reference": [ { "type": "PubMed", "id": "12842017", "url": "https://glygen.org/publication/PubMed/12842017" } ] }, { "title": "Intracellular Ca2+ and the phospholipid PIP2 regulate the taste transduction ion channel TRPM5.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2003", "authors": "Liu D, Liman ER", "evidence": [ { "database": "UniProtKB", "id": "Q9JJH7", "url": "https://www.uniprot.org/uniprot/Q9JJH7" } ], "reference": [ { "type": "PubMed", "id": "14657398", "url": "https://glygen.org/publication/PubMed/14657398" } ] }, { "title": "Comparison of functional properties of the Ca2+-activated cation channels TRPM4 and TRPM5 from mice.", "journal": "Cell Calcium", "date": "2005", "authors": "Ullrich ND, Voets T, Prenen J, Vennekens R, Talavera K, Droogmans G, Nilius B", "evidence": [ { "database": "UniProtKB", "id": "Q9JJH7", "url": "https://www.uniprot.org/uniprot/Q9JJH7" } ], "reference": [ { "type": "PubMed", "id": "15670874", "url": "https://glygen.org/publication/PubMed/15670874" } ] }, { "title": "Extracellular acid block and acid-enhanced inactivation of the Ca2+-activated cation channel TRPM5 involve residues in the S3-S4 and S5-S6 extracellular domains.", "journal": "J. Biol. Chem.", "date": "2005", "authors": "Liu D, Zhang Z, Liman ER", "evidence": [ { "database": "UniProtKB", "id": "Q9JJH7", "url": "https://www.uniprot.org/uniprot/Q9JJH7" } ], "reference": [ { "type": "PubMed", "id": "15731110", "url": "https://glygen.org/publication/PubMed/15731110" } ] }, { "title": "Heat activation of TRPM5 underlies thermal sensitivity of sweet taste.", "journal": "Nature", "date": "2005", "authors": "Talavera K, Yasumatsu K, Voets T, Droogmans G, Shigemura N, Ninomiya Y, Margolskee RF, Nilius B", "evidence": [ { "database": "UniProtKB", "id": "Q9JJH7", "url": "https://www.uniprot.org/uniprot/Q9JJH7" } ], "reference": [ { "type": "PubMed", "id": "16355226", "url": "https://glygen.org/publication/PubMed/16355226" } ] }, { "title": "Trpm5 null mice respond to bitter, sweet, and umami compounds.", "journal": "Chem. Senses", "date": "2006", "authors": "Rong M., Ninomiya Y., Yoshida R., Margolskee R.F., Kokrashvili Z., Mosinger B. Jr., Damak S., Shigemura N., Yasumatsu K., Glendinning J.I., Perez C.A.", "evidence": [ { "database": "UniProtKB", "id": "Q9JJH7", "url": "https://www.uniprot.org/uniprot/Q9JJH7" } ], "reference": [ { "type": "PubMed", "id": "16436689", "url": "https://glygen.org/publication/PubMed/16436689" } ] }, { "title": "Arachidonic acid can function as a signaling modulator by activating the TRPM5 cation channel in taste receptor cells.", "journal": "Biochim. Biophys. Acta", "date": "2006", "authors": "Abe K., Mori Y., Nakanishi H., Matsumoto I., Misaka T., Wakamori M., Taguchi R., Oike H.", "evidence": [ { "database": "UniProtKB", "id": "Q9JJH7", "url": "https://www.uniprot.org/uniprot/Q9JJH7" } ], "reference": [ { "type": "PubMed", "id": "16935556", "url": "https://glygen.org/publication/PubMed/16935556" } ] }, { "title": "Olfactory neurons expressing transient receptor potential channel M5 (TRPM5) are involved in sensing semiochemicals.", "journal": "Proc. Natl. Acad. Sci. 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