{ "uniprot_canonical_ac": "Q9JI90-1", "uniprot_ac": "Q9JI90", "uniprot_id": "RNF14_MOUSE", "mass": { "chemical_mass": 54926.0, "monoisotopic_mass": 54926.0 }, "refseq": { "ac": "NP_001158093", "name": "E3 ubiquitin-protein ligase RNF14 isoform a", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158093" }, "gene_names": [ { "name": "Rnf14", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q9JI90", "id": "Q9JI90" }, { "name": "2310075C09Rik; 2610005D23Rik; D18Ertd188e; D7Bwg0165e; Triad2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158094", "id": "NP_001158094" }, { "name": "Rnf14", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158094", "id": "NP_001158094" }, { "name": "Triad2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9JI90", "id": "Q9JI90" } ], "protein_names": [ { "name": "E3 ubiquitin-protein ligase RNF14", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q9JI90" }, { "name": "2.3.2.31", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9JI90" }, { "name": "E3 ubiquitin-protein ligase RNF14 isoform a", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158093", "id": "NP_001158093" }, { "name": "E3 ubiquitin-protein ligase RNF14 isoform b", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158094", "id": "NP_001158094" }, { "name": "RING finger protein 14", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9JI90" }, { "name": "TRIAD2 type I; E3 ubiquitin-protein ligase RNF14; protein Triad2; androgen receptor-associated protein 54", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158093", "id": "NP_001158093" } ], "function": [ { "annotation": "E3 ubiquitin-protein ligase that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes (By similarity). Recruited to stalled ribosomes by the ribosome collision sensor GCN1 and mediates ubiquitination of EEF1A1/eEF1A, leading to its degradation (By similarity). In addition to EEF1A1/eEF1A, RNF14 catalyzes ubiquitination of other translation factors on stalled ribosomes: mediates ubiquitination and degradation of ETF1/eRF1 and ubiquitination of ribosomal proteins RPL0, RPL1, RPL12, RPS13 and RPS17 (By similarity). Independently of its function in the response to stalled ribosomes, acts as a regulator of transcription in Wnt signaling via its interation with TCF transcription factors (TCF7/TCF1, TCF7L1/TCF3 and TCF7L2/TCF4) (By similarity). May also play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription (By similarity). May regulate the expression of both mitochondrial and immune related genes in skeletal muscle (PubMed:24472305).", "evidence": [ { "database": "UniProtKB", "id": "Q9JI90", "url": "https://www.uniprot.org/uniprot/Q9JI90#function" }, { "database": "UniProtKB", "id": "Q9UBS8", "url": "https://www.uniprot.org/uniprot/Q9UBS8#function" }, { "database": "PubMed", "id": "24472305", "url": "https://glygen.org/publication/PubMed/24472305" } ] }, { "annotation": "RNF14 influences the expression of both mitochondrial and immune related genes Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001158094", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158094" }, { "database": "PubMed", "id": "24472305", "url": "https://glygen.org/publication/PubMed/24472305" }, { "database": "RefSeq", "id": "NP_001158093", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158093" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q9JI90", "url": "https://www.uniprot.org/uniprot/Q9JI90" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Rnf14", "url": "https://www.uniprot.org/uniprot/Q9JI90", "locus": { "chromosome": "18", "start_pos": 38450902, "end_pos": 38417590, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000060450", "url": "https://www.ensembl.org/id/ENSMUSG00000060450" } ] } } ], "crossref": [ { "id": "ENSMUSG00000060450", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000060450", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd16628", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16628", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd20341", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20341", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd20354", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20354", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "56736", "url": "https://www.ncbi.nlm.nih.gov/gene/56736", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q9JI90", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q9JI90*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001841", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001841", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002867", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002867", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003903", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003903", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006575", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006575", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016135", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016135", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017907", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017907", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031127", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031127", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031128", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031128", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040213", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040213", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044066", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044066", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047548", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047548", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:56736", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:56736", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1929668", "url": "http://www.informatics.jax.org/marker/MGI:1929668", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "PRSWCQG", "url": "https://omabrowser.org/oma/group/PRSWCQG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "4338126at2759", "url": "http://www.orthodb.org/?query=4338126at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11685", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11685", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11685:SF371", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11685:SF371", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12292", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12292", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12292:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12292:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF01485", "url": "http://pfam.xfam.org/family/PF01485", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF05773", "url": "http://pfam.xfam.org/family/PF05773", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q9JI90", "url": "http://purl.obolibrary.org/obo/PR_Q9JI90", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983168", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001158093", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158093", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A494B8X2", "url": "https://www.uniprot.org/uniprot/A0A494B8X2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A494B8X2-1", "url": "https://www.uniprot.org/uniprot/A0A494B8X2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A494B9F3", "url": "https://www.uniprot.org/uniprot/A0A494B9F3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A494B9F3-1", "url": "https://www.uniprot.org/uniprot/A0A494B9F3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A494B9N7", "url": "https://www.uniprot.org/uniprot/A0A494B9N7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A494B9N7-1", "url": "https://www.uniprot.org/uniprot/A0A494B9N7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A494B9U7", "url": "https://www.uniprot.org/uniprot/A0A494B9U7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A494B9U7-1", "url": "https://www.uniprot.org/uniprot/A0A494B9U7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A494BA93", "url": "https://www.uniprot.org/uniprot/A0A494BA93", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A494BA93-1", "url": "https://www.uniprot.org/uniprot/A0A494BA93-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A494BAP8", "url": "https://www.uniprot.org/uniprot/A0A494BAP8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A494BAP8-1", "url": "https://www.uniprot.org/uniprot/A0A494BAP8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A494BAR9", "url": "https://www.uniprot.org/uniprot/A0A494BAR9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A494BAR9-1", "url": "https://www.uniprot.org/uniprot/A0A494BAR9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A494BBA9", "url": "https://www.uniprot.org/uniprot/A0A494BBA9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A494BBA9-1", "url": "https://www.uniprot.org/uniprot/A0A494BBA9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A494BBJ7", "url": "https://www.uniprot.org/uniprot/A0A494BBJ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A494BBJ7-1", "url": "https://www.uniprot.org/uniprot/A0A494BBJ7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A494BBK5", "url": "https://www.uniprot.org/uniprot/A0A494BBK5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A494BBK5-1", "url": "https://www.uniprot.org/uniprot/A0A494BBK5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A494BBM2", "url": "https://www.uniprot.org/uniprot/A0A494BBM2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A494BBM2-1", "url": "https://www.uniprot.org/uniprot/A0A494BBM2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3XA54", "url": "https://www.uniprot.org/uniprot/G3XA54", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3XA54-1", "url": "https://www.uniprot.org/uniprot/G3XA54-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9JI90", "url": "https://www.uniprot.org/uniprot/Q9JI90", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9JI90-1", "url": "https://www.uniprot.org/uniprot/Q9JI90-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9JI90-2", "url": "https://www.uniprot.org/uniprot/Q9JI90-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSAEDLEAQEDELLALASIYDADEFRKAESVQGGETRIYLDLPQNFKIFVSGNSNESLQNSGFEYTICFLPPLVLNFELPPDYPSSSPPSFTLSGKWLSPTQLSALCKHLDNLWEEHRGRVVLFAWMQFLKEETLTYLNIVSPFELKMGSQKKVQRRATAQASSSTELGVGGAAAADVDQEETVDERAVQDVESLSSLIQEILDFNQARQTKCFNSKLFLCSICFCEKLGSDCMYFLECKHVYCKACLKDYFEIQIKDGQVKCLNCPEPQCPSVATPGQVKELVEADLFARYDRLLLQSTLDLMADVVYCPRPCCQLPVMQEPGGTMAICSSCNFAFCTLCRLTYHGLSPCKVTAEKLIDLRNEYLQADEATKRFLEQRYGKRVIQKALEEMESKDWLEKNSKSCPCCGTPIQKLDGCNKMTCTGCMQYFCWICMGSLSRANPYRHFTDSESPCFNRLFHAVDINGDMWEDEIEEDDDDEDDDDD", "length": 485, "header": "sp|Q9JI90-1|RNF14_MOUSE Isoform 1 of E3 ubiquitin-protein ligase RNF14 OS=Mus musculus OX=10090 GN=Rnf14 PE=1 SV=2 CANONICAL=Q9JI90-1" }, "isoforms": [ { "isoform_ac": "A0A494B8X2-1", "url": "", "sequence": { "sequence": "MSAEDLEAQEDELLALASIYDADEFRKAESVQGGETRIYLDLPQNFKIFVSGNSNESLQNSGFEYTICFLPPLVLNFELPPDYPSSSPPSFTLSGKWLSPTQLSALCKHLDNLWEEHRGRVVLFAWMQFLKEETLTYLNIVSPFELKMGSQKKVQRRATAQASSSTELGVGGAAAADVDQEET", "length": 183, "header": "tr|A0A494B8X2-1|RNF14_MOUSE Computationally mapped isoform of E3 ubiquitin-protein ligase RNF14 OS=Mus musculus OX=10090 GN=Rnf14 PE=1 SV=1 CANONICAL=Q9JI90-1" }, "locus": { "chromosome": "18", "start_pos": 38441160, "end_pos": 38433490, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000237211.2", "url": "https://www.ensembl.org/id/ENSMUST00000237211.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000157387.2", "url": "https://www.ensembl.org/id/ENSMUSP00000157387.2" } ] } }, { "isoform_ac": "A0A494B9F3-1", "url": "", "sequence": { "sequence": "MSAEDLEAQEDELLALASIYDADEFRKAESVQGGETRIYLDLPQNFKIFVSGNSNESLQNSGFEYTICFLPPLVLNFELPPDYPSSSPPSFTLS", "length": 94, "header": "tr|A0A494B9F3-1|RNF14_MOUSE Computationally mapped isoform of E3 ubiquitin-protein ligase RNF14 OS=Mus musculus OX=10090 GN=Rnf14 PE=1 SV=1 CANONICAL=Q9JI90-1" }, "locus": { "chromosome": "18", "start_pos": 38434836, "end_pos": 38433490, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000236982.2", "url": "https://www.ensembl.org/id/ENSMUST00000236982.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000157587.2", "url": "https://www.ensembl.org/id/ENSMUSP00000157587.2" } ] } }, { "isoform_ac": "A0A494B9N7-1", "url": "", "sequence": { "sequence": "MSAEDLEAQEDELLALASIYDADEFRKAESVQGGETRIYLDLPQNFKIFVSGNSNESLQNSGFEYTICFLPPLVLNFELPPDYPSSS", "length": 87, "header": "tr|A0A494B9N7-1|RNF14_MOUSE Computationally mapped isoform of E3 ubiquitin-protein ligase RNF14 OS=Mus musculus OX=10090 GN=Rnf14 PE=1 SV=1 CANONICAL=Q9JI90-1" }, "locus": { "chromosome": "18", "start_pos": 38434815, "end_pos": 38433490, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000237089.2", "url": "https://www.ensembl.org/id/ENSMUST00000237089.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000157732.2", "url": "https://www.ensembl.org/id/ENSMUSP00000157732.2" } ] } }, { "isoform_ac": "A0A494B9U7-1", "url": "", "sequence": { "sequence": "MSAEDLEAQEDELLALASIYDADEFRKAESVQGGETRIYL", "length": 40, "header": "tr|A0A494B9U7-1|RNF14_MOUSE Computationally mapped isoform of E3 ubiquitin-protein ligase RNF14 OS=Mus musculus OX=10090 GN=Rnf14 PE=1 SV=1 CANONICAL=Q9JI90-1" }, "locus": { "chromosome": "18", "start_pos": 38433609, "end_pos": 38433490, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000236319.2", "url": "https://www.ensembl.org/id/ENSMUST00000236319.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000157812.2", "url": "https://www.ensembl.org/id/ENSMUSP00000157812.2" } ] } }, { "isoform_ac": "A0A494BA93-1", "url": "", "sequence": { "sequence": "MSAEDLEAQEDELLALVVPCRGY", "length": 23, "header": "tr|A0A494BA93-1|RNF14_MOUSE Computationally mapped isoform of E3 ubiquitin-protein ligase RNF14 OS=Mus musculus OX=10090 GN=Rnf14 PE=1 SV=1 CANONICAL=Q9JI90-1" }, "locus": { "chromosome": "18", "start_pos": 38449598, "end_pos": 38433490, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000237416.2", "url": "https://www.ensembl.org/id/ENSMUST00000237416.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000157933.2", "url": "https://www.ensembl.org/id/ENSMUSP00000157933.2" } ] } }, { "isoform_ac": "A0A494BAP8-1", "url": "", "sequence": { "sequence": "MSAEDLEAQEDELLALASIYDADEFRKAESVQGGETRIYLDLPQNFKIF", "length": 49, "header": "tr|A0A494BAP8-1|RNF14_MOUSE Computationally mapped isoform of E3 ubiquitin-protein ligase RNF14 OS=Mus musculus OX=10090 GN=Rnf14 PE=1 SV=1 CANONICAL=Q9JI90-1" }, "locus": { "chromosome": "18", "start_pos": 38433636, "end_pos": 38433490, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000237824.2", "url": "https://www.ensembl.org/id/ENSMUST00000237824.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000158137.2", "url": "https://www.ensembl.org/id/ENSMUSP00000158137.2" } ] } }, { "isoform_ac": "A0A494BAR9-1", "url": "", "sequence": { "sequence": "MSAEDLEAQEDELLALASIYDADEFRKA", "length": 28, "header": "tr|A0A494BAR9-1|RNF14_MOUSE Computationally mapped isoform of E3 ubiquitin-protein ligase RNF14 OS=Mus musculus OX=10090 GN=Rnf14 PE=1 SV=1 CANONICAL=Q9JI90-1" }, "locus": { "chromosome": "18", "start_pos": 38433573, "end_pos": 38433490, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000235811.2", "url": "https://www.ensembl.org/id/ENSMUST00000235811.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000158209.2", "url": "https://www.ensembl.org/id/ENSMUSP00000158209.2" } ] } }, { "isoform_ac": "A0A494BBA9-1", "url": "", "sequence": { "sequence": "MSAEDLEAQEDELLALASIYDADEFRKAESVQGGETRIYLDLPQNFKIFVSGNSNESLQNSGFEYTICFLPPLVLNFELPPDYPSSSPPSFTLSGKWLSPTQ", "length": 102, "header": "tr|A0A494BBA9-1|RNF14_MOUSE Computationally mapped isoform of E3 ubiquitin-protein ligase RNF14 OS=Mus musculus OX=10090 GN=Rnf14 PE=1 SV=1 CANONICAL=Q9JI90-1" }, "locus": { "chromosome": "18", "start_pos": 38434860, "end_pos": 38433490, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000235491.2", "url": "https://www.ensembl.org/id/ENSMUST00000235491.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000158444.2", "url": "https://www.ensembl.org/id/ENSMUSP00000158444.2" } ] } }, { "isoform_ac": "A0A494BBJ7-1", "url": "", "sequence": { "sequence": "MSAEDLEAQEDELLALLSALCKHLDNLWEEHRGRVVLFAWMQFLKEETLTYLNIVSPFELKMGSQKKVQRRATAQASSSTELGVGGAAAADVDQEETVDERAVQDVESLSSLIQEILDFNQARQTKCFNSKLFLCSICFCEK", "length": 142, "header": "tr|A0A494BBJ7-1|A0A494BBJ7_MOUSE Computationally mapped isoform of Ring finger protein 14 OS=Mus musculus OX=10090 GN=Rnf14 PE=1 SV=1 CANONICAL=Q9JI90-1" }, "locus": { "chromosome": "18", "start_pos": 38441295, "end_pos": 38433490, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000235549.2", "url": "https://www.ensembl.org/id/ENSMUST00000235549.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000158487.2", "url": "https://www.ensembl.org/id/ENSMUSP00000158487.2" } ] } }, { "isoform_ac": "A0A494BBK5-1", "url": "", "sequence": { "sequence": "MSAEDLEAQEDELLALASIYDADEFRKAESVQGGETRIYLDLPQNFKIFVSGNSNESLQNSGFEY", "length": 65, "header": "tr|A0A494BBK5-1|RNF14_MOUSE Computationally mapped isoform of E3 ubiquitin-protein ligase RNF14 OS=Mus musculus OX=10090 GN=Rnf14 PE=1 SV=1 CANONICAL=Q9JI90-1" }, "locus": { "chromosome": "18", "start_pos": 38434749, "end_pos": 38433490, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000237903.2", "url": "https://www.ensembl.org/id/ENSMUST00000237903.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000158563.2", "url": "https://www.ensembl.org/id/ENSMUSP00000158563.2" } ] } }, { "isoform_ac": "A0A494BBM2-1", "url": "", "sequence": { "sequence": "MSAEDLEAQEDELLALAIQMSLSRIVALNTPFAFCHHLC", "length": 39, "header": "tr|A0A494BBM2-1|RNF14_MOUSE Computationally mapped isoform of E3 ubiquitin-protein ligase RNF14 OS=Mus musculus OX=10090 GN=Rnf14 PE=1 SV=1 CANONICAL=Q9JI90-1" }, "locus": { "chromosome": "18", "start_pos": 38434777, "end_pos": 38433490, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000237667.2", "url": "https://www.ensembl.org/id/ENSMUST00000237667.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000158572.2", "url": "https://www.ensembl.org/id/ENSMUSP00000158572.2" } ] } }, { "isoform_ac": "G3XA54-1", "url": "", "sequence": { "sequence": "MQFLKEETLTYLNIVSPFELKMGSQKKVQRRATAQASSSTELGVGGAAAADVDQEETVDERAVQDVESLSSLIQEILDFNQARQTKCFNSKLFLCSICFCEKLGSDCMYFLECKHVYCKACLKDYFEIQIKDGQVKCLNCPEPQCPSVATPGQVKELVEADLFARYDRLLLQSTLDLMADVVYCPRPCCQLPVMQEPGGTMAICSSCNFAFCTLCRLTYHGLSPCKVTAEKLIDLRNEYLQADEATKRFLEQRYGKRVIQKALEEMESKDWLEKNSKSCPCCGTPIQKLDGCNKMTCTGCMQYFCWICMGSLSRANPYRHFTDSESPCFNRLFHAVDINGDMWEDEIEEDDDDEDDDDD", "length": 359, "header": "tr|G3XA54-1|RNF14_MOUSE Computationally mapped isoform of E3 ubiquitin-protein ligase RNF14 OS=Mus musculus OX=10090 GN=Rnf14 PE=1 SV=1 CANONICAL=Q9JI90-1" }, "locus": { "chromosome": "18", "start_pos": 38449662, "end_pos": 38440990, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000170811.8", "url": "https://www.ensembl.org/id/ENSMUST00000170811.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000133070.2", "url": "https://www.ensembl.org/id/ENSMUSP00000133070.2" } ] } }, { "isoform_ac": "Q9JI90-1", "url": "", "sequence": { "sequence": "MSAEDLEAQEDELLALASIYDADEFRKAESVQGGETRIYLDLPQNFKIFVSGNSNESLQNSGFEYTICFLPPLVLNFELPPDYPSSSPPSFTLSGKWLSPTQLSALCKHLDNLWEEHRGRVVLFAWMQFLKEETLTYLNIVSPFELKMGSQKKVQRRATAQASSSTELGVGGAAAADVDQEETVDERAVQDVESLSSLIQEILDFNQARQTKCFNSKLFLCSICFCEKLGSDCMYFLECKHVYCKACLKDYFEIQIKDGQVKCLNCPEPQCPSVATPGQVKELVEADLFARYDRLLLQSTLDLMADVVYCPRPCCQLPVMQEPGGTMAICSSCNFAFCTLCRLTYHGLSPCKVTAEKLIDLRNEYLQADEATKRFLEQRYGKRVIQKALEEMESKDWLEKNSKSCPCCGTPIQKLDGCNKMTCTGCMQYFCWICMGSLSRANPYRHFTDSESPCFNRLFHAVDINGDMWEDEIEEDDDDEDDDDD", "length": 485, "header": "sp|Q9JI90-1|RNF14_MOUSE Isoform 1 of E3 ubiquitin-protein ligase RNF14 OS=Mus musculus OX=10090 GN=Rnf14 PE=1 SV=2 CANONICAL=Q9JI90-1" }, "locus": { "chromosome": "18", "start_pos": 38449662, "end_pos": 38433490, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000236116", "url": "https://www.ensembl.org/id/ENSMUST00000236116" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000157833", "url": "https://www.ensembl.org/id/ENSMUSP00000157833" } ] } }, { "isoform_ac": "Q9JI90-2", "url": "", "sequence": { "sequence": "MSAEDLEAQEDELLALASIYDADEFRKAESVQGGETRIYLDLPQNFKIFVSALCSLQAPRQPVGRTPRQSGAVCLDAVS", "length": 79, "header": "sp|Q9JI90-2|RNF14_MOUSE Isoform 2 of E3 ubiquitin-protein ligase RNF14 OS=Mus musculus OX=10090 GN=Rnf14 PE=1 SV=2 CANONICAL=Q9JI90-1" }, "locus": { "chromosome": "18", "start_pos": 38441000, "end_pos": 38433490, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000236649", "url": "https://www.ensembl.org/id/ENSMUST00000236649" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000157501", "url": "https://www.ensembl.org/id/ENSMUSP00000157501" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 349, "end_pos": 349, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9JI90", "url": "https://www.uniprot.org/uniprot/Q9JI90" } ], "site_lbl": "Ser349" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "RNF14 is a regulator of mitochondrial and immune function in muscle.", "journal": "BMC Syst. Biol.", "date": "2014", "authors": "Ingham AB, Osborne SA, Menzies M, Briscoe S, Chen W, Kongsuwan K, Reverter A, Jeanes A, Dalrymple BP, Wijffels G, Seymour R, Hudson NJ", "evidence": [ { "database": "UniProtKB", "id": "Q9JI90", "url": "https://www.uniprot.org/uniprot/Q9JI90" }, { "database": "RefSeq", "id": "NP_001158093", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158093" }, { "database": "RefSeq", "id": "NP_001158094", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158094" } ], "reference": [ { "type": "PubMed", "id": "24472305", "url": "https://glygen.org/publication/PubMed/24472305" } ] } ], "pathway": [ { "id": "mmu:56736", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:56736", "resource": "KEGG Pathway" }, { "id": "R-MMU-983168", "name": "Antigen processing: Ubiquitination & Proteasome degradation", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "A6J3F9-1", "protein_name": "RBR-type E3 ubiquitin transferase", "gene_name": "Rnf14", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSAEDLEAQEDELLALASIYDGDEFRKAESVQGGETRIYLDLPQNFKIFVSGNSNECLQNSGFEYTICFLPPLVLNFELPPDYPSSSPPSFTLSGKWLSPTQLSALCKHLDNLWEEHRGRVVLFAWMQFLKEETLTYLNIVSPFELKMGSQKKVQRRTTAQASSNTELALGGAAAAAAASDVDQEDSVDERAVQDVESLSSLIQEILDFNQDRQMKCFNSKLFLCSICFCEKLGSDCMYFLECRHVYCKACLKDYFEIQIKDGQVKCLNCPEPQCSSVATPGQVKELVEADLFARYDRLLLQSTLDLMADVVYCPRPCCQLPVMQEPGGTMAICSSCNFAFCTLCRLTYHGVSPCKVTAEKLIDLRNEYLQADEATKRFLEQRYGKRVIQKALEEMESKDWLEKNSKSCPCCGTPIQKLDGCNKMTCTGCMQYFCWVCMGSLSRANPYKHFTDPDSPCFNRLFHAVDVNGDIWEDEIED", "length": 479 }, "evidence": [ { "id": "45232765", "url": "http://www.informatics.jax.org/homology/45232765", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9UBS8-1", "protein_name": "E3 ubiquitin-protein ligase RNF14", "gene_name": "RNF14", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSSEDREAQEDELLALASIYDGDEFRKAESVQGGETRIYLDLPQNFKIFVSGNSNECLQNSGFEYTICFLPPLVLNFELPPDYPSSSPPSFTLSGKWLSPTQLSALCKHLDNLWEEHRGSVVLFAWMQFLKEETLAYLNIVSPFELKIGSQKKVQRRTAQASPNTELDFGGAAGSDVDQEEIVDERAVQDVESLSNLIQEILDFDQAQQIKCFNSKLFLCSICFCEKLGSECMYFLECRHVYCKACLKDYFEIQIRDGQVQCLNCPEPKCPSVATPGQVKELVEAELFARYDRLLLQSSLDLMADVVYCPRPCCQLPVMQEPGCTMGICSSCNFAFCTLCRLTYHGVSPCKVTAEKLMDLRNEYLQADEANKRLLDQRYGKRVIQKALEEMESKEWLEKNSKSCPCCGTPIEKLDGCNKMTCTGCMQYFCWICMGSLSRANPYKHFNDPGSPCFNRLFYAVDVDDDIWEDEVED", "length": 474 }, "evidence": [ { "id": "45232765", "url": "http://www.informatics.jax.org/homology/45232765", "database": "MGI" }, { "id": "Q9JI90", "url": "https://omabrowser.org/oma/group/Q9JI90/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q9JI90", "url": "https://www.uniprot.org/uniprot/Q9JI90" } ], "pmid": "" }, { "name": "ubiquitin-protein transferase activity", "id": "GO:0004842", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004842", "evidence": [ { "database": "UniProtKB", "id": "Q9JI90", "url": "https://www.uniprot.org/uniprot/Q9JI90" } ], "pmid": "" }, { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "Q9JI90", "url": "https://www.uniprot.org/uniprot/Q9JI90" } ], "pmid": "" }, { "name": "ubiquitin-like protein transferase activity", "id": "GO:0019787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019787", "evidence": [ { "database": "UniProtKB", "id": "Q9JI90", "url": "https://www.uniprot.org/uniprot/Q9JI90" } ], "pmid": "" }, { "name": "ubiquitin conjugating enzyme binding", "id": "GO:0031624", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031624", "evidence": [ { "database": "UniProtKB", "id": "Q9JI90", "url": "https://www.uniprot.org/uniprot/Q9JI90" } ], "pmid": "" }, { "name": "nuclear androgen receptor binding", "id": "GO:0050681", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050681", "evidence": [ { "database": "UniProtKB", "id": "Q9JI90", "url": "https://www.uniprot.org/uniprot/Q9JI90" } ], "pmid": "" }, { "name": "molecular function inhibitor activity", "id": "GO:0140678", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140678", "evidence": [ { "database": "UniProtKB", "id": "Q9JI90", "url": "https://www.uniprot.org/uniprot/Q9JI90" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 10, "go_terms": [ { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "Q9JI90", "url": "https://www.uniprot.org/uniprot/Q9JI90" } ], "pmid": "" }, { "name": "rescue of stalled ribosome", "id": "GO:0072344", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072344", "evidence": [ { "database": "UniProtKB", "id": "Q9JI90", "url": "https://www.uniprot.org/uniprot/Q9JI90" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "Q9JI90", "url": "https://www.uniprot.org/uniprot/Q9JI90" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "Q9JI90", "url": "https://www.uniprot.org/uniprot/Q9JI90" } ], "pmid": "" }, { "name": "regulation of canonical Wnt signaling pathway", "id": "GO:0060828", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060828", "evidence": [ { "database": "UniProtKB", "id": "Q9JI90", "url": "https://www.uniprot.org/uniprot/Q9JI90" } ], "pmid": "" }, { "name": "protein polyubiquitination", "id": "GO:0000209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000209", "evidence": [ { "database": "UniProtKB", "id": "Q9JI90", "url": "https://www.uniprot.org/uniprot/Q9JI90" } ], "pmid": "" }, { "name": "positive regulation of proteasomal ubiquitin-dependent protein catabolic process", "id": "GO:0032436", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032436", "evidence": [ { "database": "UniProtKB", "id": "Q9JI90", "url": "https://www.uniprot.org/uniprot/Q9JI90" } ], "pmid": "" }, { "name": "ubiquitin-dependent protein catabolic process", "id": "GO:0006511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", "evidence": [ { "database": "UniProtKB", "id": "Q9JI90", "url": "https://www.uniprot.org/uniprot/Q9JI90" } ], "pmid": "" }, { "name": "regulation of androgen receptor signaling pathway", "id": "GO:0060765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060765", "evidence": [ { "database": "UniProtKB", "id": "Q9JI90", "url": "https://www.uniprot.org/uniprot/Q9JI90" } ], "pmid": "" }, { "name": "protein K6-linked ubiquitination", "id": "GO:0085020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0085020", "evidence": [ { "database": "UniProtKB", "id": "Q9JI90", "url": "https://www.uniprot.org/uniprot/Q9JI90" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q9JI90", "url": "https://www.uniprot.org/uniprot/Q9JI90" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q9JI90", "url": "https://www.uniprot.org/uniprot/Q9JI90" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q9JI90", "url": "https://www.uniprot.org/uniprot/Q9JI90" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q9JI90", "url": "https://www.uniprot.org/uniprot/Q9JI90" } ], "pmid": "" }, { "name": "cytosolic ribosome", "id": "GO:0022626", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022626", "evidence": [ { "database": "UniProtKB", "id": "Q9JI90", "url": "https://www.uniprot.org/uniprot/Q9JI90" } ], "pmid": "" }, { "name": "ubiquitin ligase complex", "id": "GO:0000151", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000151", "evidence": [ { "database": "UniProtKB", "id": "Q9JI90", "url": "https://www.uniprot.org/uniprot/Q9JI90" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 55, "end_pos": 57, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "RING-type zinc finger-dependent and UBE2E2-dependent autoubiquitination.", "evidence": [ { "database": "UniProtKB", "id": "Q9JI90", "url": "https://www.uniprot.org/uniprot/Q9JI90" }, { "database": "PubMed", "id": "Q9UBS8", "url": "https://glygen.org/publication/PubMed/Q9UBS8" } ] } ], "interactions": [], "reactions": [ { "id": "R-MMU-983140", "name": "Transfer of Ub from E2 to substrate and release of E2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8CFI0-1", "Q6P073-1", "Q8CFI2-1", "Q91W82-1", "Q921J4-1", "Q922B6-1", "Q99PQ2-1", "Q9WUD1-1", "Q9WUB0-1", "Q8BM54-1", "Q8C432-1", "Q9DBU5-1", "Q9ET26-1", "Q9JI90-1", "Q7TMY8-1", "Q1PSW8-1", "Q8R516-1", "Q9D074-1", "O55176-3", "Q8BH75-1", "Q99KR6-1", "Q9D0C1-1", "Q9WTV7-1", "G5E870-1", "Q80WG7-1", "Q80X56-1", "Q8CH72-1", "Q3UE37-1", "Q8CCJ3-3", "Q8VDW4-1", "Q06986-1", "P60605-1", "Q3U487-1", "P97868-1", "Q5XPI3-1", "Q6PDX6-1", "Q91YL2-1", "A2A5Z6-1", "Q925F4-1", "Q99ML9-1", "Q9JIY2-1", "Q69ZI1-1", "O08759-1", "P62257-1", "Q6WKZ8-1", "Q6ZPJ3-1", "A2AN08-1", "Q71FD5-1", "Q8CHG5-1", "P61092-1", "Q3UIR3-1", "Q6I6G8-1", "Q05A36-1", "Q9QXP6-1", "A2A7Q9-1", "E9Q555-1", "P50636-1", "Q9QZR0-1", "Q9QZS2-1", "P61089-1", "Q38HM4-1", "Q9ESN2-1", "Q5FWH2-3", "Q8BX13-1", "O70481-1", "P52482-1", "P61080-1", "P61087-1", "P62254-1", "P62838-1", "P63147-1", "P68037-1", "Q6ZWZ2-1", "Q80U95-1", "Q8K2Z8-1", "Q9CY34-1", "Q9D1C1-1", "Q9ES34-1", "Q9JJZ4-1", "Q9QZU9-1", "Q9Z255-1", "Q91V17-1", "Q9CR50-1", "Q3TTA7-1", "Q80TR8-1", "O70263-1", "Q80U04-1", "Q80ZI6-1", "D3YYI7-1", "Q9CQE0-1", "Q8C863-1", "Q9WVS6-1", "Q62191-1", "Q7TPV2-1", "Q3U0D9-1", "Q4U2R1-1", "P46935-1", "F2Z461-1", "P62878-1", "Q8BKD6-1", "Q9CUN6-1", "Q8BZZ3-1", "Q69ZR2-1", "Q6PAV2-1", "Q8CDU6-1", "Q8C7M3-1", "Q8VIG6-1", "E9Q735-1", "P52483-1", "P61079-1", "P61082-1", "Q7TSS2-1", "Q9Z1K6-1", "Q8VEM1-1", "Q6A009-1", "Q5NCC3-1", "Q6PCX9-1", "Q810I2-1", "Q9DBK7-1" ], "evidence": [ { "id": "R-MMU-983140", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983140" } ] }, { "id": "R-MMU-983147", "name": "Release of E3 from polyubiquitinated substrate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8CFI0-1", "Q922B6-1", "Q99PQ2-1", "Q9WUD1-1", "Q9WUB0-1", "Q8BM54-1", "Q8C432-1", "Q9DBU5-1", "Q9ET26-1", "Q9JI90-1", "Q7TMY8-1", "Q1PSW8-1", "Q8R516-1", "Q9D074-1", "O55176-3", "Q8BH75-1", "Q99KR6-1", "Q9D0C1-1", "Q9WTV7-1", "G5E870-1", "Q80WG7-1", "Q80X56-1", "Q8CH72-1", "Q8CCJ3-3", "Q06986-1", "Q3U487-1", "P97868-1", "Q5XPI3-1", "Q6PDX6-1", "Q91YL2-1", "A2A5Z6-1", "Q925F4-1", "Q99ML9-1", "Q9JIY2-1", "Q69ZI1-1", "O08759-1", "Q6WKZ8-1", "A2AN08-1", "Q71FD5-1", "Q8CHG5-1", "P61092-1", "Q3UIR3-1", "Q6I6G8-1", "Q05A36-1", "Q9QXP6-1", "A2A7Q9-1", "E9Q555-1", "P50636-1", "Q9QZR0-1", "Q9QZS2-1", "Q38HM4-1", "Q9ESN2-1", "Q5FWH2-3", "Q8BX13-1", "O70481-1", "Q80U95-1", "Q9ES34-1", "Q91V17-1", "Q9CR50-1", "Q3TTA7-1", "Q80TR8-1", "O70263-1", "Q80U04-1", "Q80ZI6-1", "D3YYI7-1", "Q9CQE0-1", "Q8C863-1", "Q9WVS6-1", "Q62191-1", "Q7TPV2-1", "Q3U0D9-1", "Q4U2R1-1", "P46935-1", "F2Z461-1", "P62878-1", "Q8BKD6-1", "Q9CUN6-1", "Q8BZZ3-1", "Q69ZR2-1", "Q6PAV2-1", "Q8CDU6-1", "Q8C7M3-1", "Q8VIG6-1", "E9Q735-1", "Q9Z1K6-1", "Q8VEM1-1", "Q6A009-1", "Q5NCC3-1", "Q6PCX9-1", "Q810I2-1" ], "evidence": [ { "id": "R-MMU-983147", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983147" } ] }, { "id": "R-MMU-983156", "name": "Polyubiquitination of substrate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8CFI0-1", "Q6P073-1", "Q8CFI2-1", "Q91W82-1", "Q921J4-1", "Q922B6-1", "Q99PQ2-1", "Q9WUD1-1", "Q9WUB0-1", "Q8BM54-1", "Q8C432-1", "Q9DBU5-1", "Q9ET26-1", "Q9JI90-1", "Q7TMY8-1", "Q1PSW8-1", "Q8R516-1", "Q9D074-1", "O55176-3", "Q8BH75-1", "Q99KR6-1", "Q9D0C1-1", "Q9WTV7-1", "G5E870-1", "Q80WG7-1", "Q80X56-1", "Q8CH72-1", "Q3UE37-1", "Q8CCJ3-3", "Q8VDW4-1", "Q06986-1", "P60605-1", "Q3U487-1", "P97868-1", "Q5XPI3-1", "Q6PDX6-1", "Q91YL2-1", "A2A5Z6-1", "Q925F4-1", "Q99ML9-1", "Q9JIY2-1", "Q69ZI1-1", "O08759-1", "P62257-1", "Q6WKZ8-1", "Q6ZPJ3-1", "A2AN08-1", "Q71FD5-1", "Q8CHG5-1", "P61092-1", "Q3UIR3-1", "Q6I6G8-1", "Q05A36-1", "Q9QXP6-1", "A2A7Q9-1", "E9Q555-1", "P50636-1", "Q9QZR0-1", "Q9QZS2-1", "P61089-1", "Q38HM4-1", "Q9ESN2-1", "Q5FWH2-3", "Q8BX13-1", "O70481-1", "P52482-1", "P61080-1", "P61087-1", "P62254-1", "P62838-1", "P63147-1", "P68037-1", "Q6ZWZ2-1", "Q80U95-1", "Q8K2Z8-1", "Q9CY34-1", "Q9D1C1-1", "Q9ES34-1", "Q9JJZ4-1", "Q9QZU9-1", "Q9Z255-1", "Q91V17-1", "Q9CR50-1", "Q3TTA7-1", "Q80TR8-1", "O70263-1", "Q80U04-1", "Q80ZI6-1", "D3YYI7-1", "Q9CQE0-1", "Q8C863-1", "Q9WVS6-1", "Q62191-1", "Q7TPV2-1", "Q3U0D9-1", "Q4U2R1-1", "P46935-1", "F2Z461-1", "P62878-1", "Q8BKD6-1", "Q9CUN6-1", "Q8BZZ3-1", "Q69ZR2-1", "Q6PAV2-1", "Q8CDU6-1", "Q8C7M3-1", "Q8VIG6-1", "E9Q735-1", "P52483-1", "P61079-1", "P61082-1", "Q7TSS2-1", "Q9Z1K6-1", "Q8VEM1-1", "Q6A009-1", "Q5NCC3-1", "Q6PCX9-1", "Q810I2-1", "Q9DBK7-1" ], "evidence": [ { "id": "R-MMU-983156", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983156" } ] }, { "id": "R-MMU-983157", "name": "Interaction of E3 with substrate and E2-Ub complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8CFI0-1", "Q6P073-1", "Q8CFI2-1", "Q91W82-1", "Q921J4-1", "Q922B6-1", "Q99PQ2-1", "Q9WUD1-1", "Q9WUB0-1", "Q8BM54-1", "Q8C432-1", "Q9DBU5-1", "Q9ET26-1", "Q9JI90-1", "Q7TMY8-1", "Q1PSW8-1", "Q8R516-1", "Q9D074-1", "O55176-3", "Q8BH75-1", "Q99KR6-1", "Q9D0C1-1", "Q9WTV7-1", "G5E870-1", "Q80WG7-1", "Q80X56-1", "Q8CH72-1", "Q3UE37-1", "Q8CCJ3-3", "Q8VDW4-1", "Q06986-1", "P60605-1", "Q3U487-1", "P97868-1", "Q5XPI3-1", "Q6PDX6-1", "Q91YL2-1", "A2A5Z6-1", "Q925F4-1", "Q99ML9-1", "Q9JIY2-1", "Q69ZI1-1", "O08759-1", "P62257-1", "Q6WKZ8-1", "Q6ZPJ3-1", "A2AN08-1", "Q71FD5-1", "Q8CHG5-1", "P61092-1", "Q3UIR3-1", "Q6I6G8-1", "Q05A36-1", "Q9QXP6-1", "A2A7Q9-1", "E9Q555-1", "P50636-1", "Q9QZR0-1", "Q9QZS2-1", "P61089-1", "Q38HM4-1", "Q9ESN2-1", "Q5FWH2-3", "Q8BX13-1", "O70481-1", "P52482-1", "P61080-1", "P61087-1", "P62254-1", "P62838-1", "P63147-1", "P68037-1", "Q6ZWZ2-1", "Q80U95-1", "Q8K2Z8-1", "Q9CY34-1", "Q9D1C1-1", "Q9ES34-1", "Q9JJZ4-1", "Q9QZU9-1", "Q9Z255-1", "Q91V17-1", "Q9CR50-1", "Q3TTA7-1", "Q80TR8-1", "O70263-1", "Q80U04-1", "Q80ZI6-1", "D3YYI7-1", "Q9CQE0-1", "Q8C863-1", "Q9WVS6-1", "Q62191-1", "Q7TPV2-1", "Q3U0D9-1", "Q4U2R1-1", "P46935-1", "F2Z461-1", "P62878-1", "Q8BKD6-1", "Q9CUN6-1", "Q8BZZ3-1", "Q69ZR2-1", "Q6PAV2-1", "Q8CDU6-1", "Q8C7M3-1", "Q8VIG6-1", "E9Q735-1", "P52483-1", "P61079-1", "P61082-1", "Q7TSS2-1", "Q9Z1K6-1", "Q8VEM1-1", "Q6A009-1", "Q5NCC3-1", "Q6PCX9-1", "Q810I2-1", "Q9DBK7-1" ], "evidence": [ { "id": "R-MMU-983157", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983157" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A2A5Z6", "gene_name": "Smurf2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A2A5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2A5Z6" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "A2A5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2A5Z6" } ] } ] }, { "uniprot_ac": "A2A7Q9", "gene_name": "Rnf19b", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "A2A7Q9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2A7Q9" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "A2A7Q9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2A7Q9" } ] } ] }, { "uniprot_ac": "A2AN08", "gene_name": "Ubr4", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A2AN08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AN08" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A2AN08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AN08" } ] } ] }, { "uniprot_ac": "D3YYI7", "gene_name": "Rnf217", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "D3YYI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3YYI7" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "D3YYI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3YYI7" } ] } ] }, { "uniprot_ac": "E9Q555", "gene_name": "Rnf213", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "E9Q555", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q555" } ] }, { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E9Q555", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q555" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E9Q555", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q555" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E9Q555", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q555" } ] } ] }, { "uniprot_ac": "E9Q735", "gene_name": "Ube4a", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E9Q735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q735" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E9Q735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q735" } ] } ] }, { "uniprot_ac": "F2Z461", "gene_name": "Herc6", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "F2Z461", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F2Z461" } ] } ] }, { "uniprot_ac": "G5E870", "gene_name": "Trip12", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "G5E870", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G5E870" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "G5E870", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G5E870" } ] } ] }, { "uniprot_ac": "O08759", "gene_name": "Ube3a", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O08759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08759" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "O08759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08759" } ] } ] }, { "uniprot_ac": "O55176", "gene_name": "Pja1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O55176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55176" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "O55176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55176" } ] } ] }, { "uniprot_ac": "O70263", "gene_name": "Lnx1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O70263", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70263" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "O70263", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70263" } ] } ] }, { "uniprot_ac": "O70481", "gene_name": "Ubr1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O70481", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70481" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "O70481", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70481" } ] } ] }, { "uniprot_ac": "P46935", "gene_name": "Nedd4", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P46935", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46935" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "P46935", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46935" } ] } ] }, { "uniprot_ac": "P50636", "gene_name": "Rnf19a", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "P50636", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50636" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "P50636", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50636" } ] } ] }, { "uniprot_ac": "P52482", "gene_name": "Ube2e1", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P52482", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52482" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P52482", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52482" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P52482", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52482" } ] } ] }, { "uniprot_ac": "P52483", "gene_name": "Ube2e3", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P52483", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52483" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P52483", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52483" } ] } ] }, { "uniprot_ac": "P60605", "gene_name": "Ube2g2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P60605", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60605" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P60605", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60605" } ] } ] }, { "uniprot_ac": "P61079", "gene_name": "Ube2d3", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P61079", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61079" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P61079", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61079" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P61079", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61079" } ] } ] }, { "uniprot_ac": "P61080", "gene_name": "Ube2d1", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P61080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61080" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P61080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61080" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P61080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61080" } ] } ] }, { "uniprot_ac": "P61082", "gene_name": "Ube2m", "activity": [ { "ec_number": "2.3.2.34", "activity": "[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.", "evidence": [ { "id": "P61082", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61082" } ] }, { "ec_number": "2.3.2.34", "activity": "", "evidence": [ { "id": "P61082", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61082" } ] } ] }, { "uniprot_ac": "P61087", "gene_name": "Ube2k", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P61087", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61087" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P61087", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61087" } ] } ] }, { "uniprot_ac": "P61089", "gene_name": "Ube2n", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P61089", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61089" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P61089", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61089" } ] } ] }, { "uniprot_ac": "P61092", "gene_name": "Siah1a", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P61092", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61092" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "P61092", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61092" } ] } ] }, { "uniprot_ac": "P62254", "gene_name": "Ube2g1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P62254", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62254" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P62254", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62254" } ] } ] }, { "uniprot_ac": "P62257", "gene_name": "Ube2h", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P62257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62257" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P62257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62257" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P62257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62257" } ] } ] }, { "uniprot_ac": "P62838", "gene_name": "Ube2d2", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P62838", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62838" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P62838", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62838" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P62838", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62838" } ] } ] }, { "uniprot_ac": "P62878", "gene_name": "Rbx1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P62878", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62878" } ] }, { "ec_number": "2.3.2.32", "activity": "S-[NEDD8-protein]-yl-[E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin]-L-lysine = [E2 NEDD8-conjugating enzyme]-L-cysteine + N(6)-[NEDD8-protein]-yl-[cullin]-L-lysine.", "evidence": [ { "id": "P62878", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62878" } ] }, { "ec_number": "2.3.2.32", "activity": "", "evidence": [ { "id": "P62878", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62878" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "P62878", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62878" } ] } ] }, { "uniprot_ac": "P63147", "gene_name": "Ube2b", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P63147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63147" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P63147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63147" } ] } ] }, { "uniprot_ac": "P68037", "gene_name": "Ube2l3", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P68037", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68037" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P68037", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68037" } ] } ] }, { "uniprot_ac": "P97868", "gene_name": "Rbbp6", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P97868", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97868" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "P97868", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97868" } ] } ] }, { "uniprot_ac": "Q05A36", "gene_name": "Mex3c", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q05A36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05A36" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q05A36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05A36" } ] } ] }, { "uniprot_ac": "Q06986", "gene_name": "Siah2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q06986", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06986" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q06986", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06986" } ] } ] }, { "uniprot_ac": "Q1PSW8", "gene_name": "Trim71", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q1PSW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q1PSW8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q1PSW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q1PSW8" } ] } ] }, { "uniprot_ac": "Q38HM4", "gene_name": "Trim63", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q38HM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q38HM4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q38HM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q38HM4" } ] } ] }, { "uniprot_ac": "Q3TTA7", "gene_name": "Cblb", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q3TTA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TTA7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q3TTA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TTA7" } ] } ] }, { "uniprot_ac": "Q3U0D9", "gene_name": "Hace1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q3U0D9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3U0D9" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q3U0D9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3U0D9" } ] } ] }, { "uniprot_ac": "Q3U487", "gene_name": "Hectd3", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q3U487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3U487" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q3U487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3U487" } ] } ] }, { "uniprot_ac": "Q3UE37", "gene_name": "Ube2z", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q3UE37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UE37" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q3UE37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UE37" } ] } ] }, { "uniprot_ac": "Q3UIR3", "gene_name": "Dtx3l", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q3UIR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UIR3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q3UIR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UIR3" } ] } ] }, { "uniprot_ac": "Q4U2R1", "gene_name": "Herc2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q4U2R1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4U2R1" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q4U2R1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4U2R1" } ] } ] }, { "uniprot_ac": "Q5FWH2", "gene_name": "Unkl", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "Q5FWH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5FWH2" } ] } ] }, { "uniprot_ac": "Q5NCC3", "gene_name": "Trim41", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5NCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5NCC3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q5NCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5NCC3" } ] } ] }, { "uniprot_ac": "Q5XPI3", "gene_name": "Rnf123", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5XPI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XPI3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q5XPI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XPI3" } ] } ] }, { "uniprot_ac": "Q62191", "gene_name": "Trim21", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q62191", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62191" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q62191", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62191" } ] } ] }, { "uniprot_ac": "Q69ZI1", "gene_name": "Sh3rf1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q69ZI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q69ZI1" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q69ZI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q69ZI1" } ] } ] }, { "uniprot_ac": "Q69ZR2", "gene_name": "Hectd1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q69ZR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q69ZR2" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q69ZR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q69ZR2" } ] } ] }, { "uniprot_ac": "Q6A009", "gene_name": "Ltn1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6A009", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6A009" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q6A009", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6A009" } ] } ] }, { "uniprot_ac": "Q6I6G8", "gene_name": "Hecw2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6I6G8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6I6G8" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q6I6G8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6I6G8" } ] } ] }, { "uniprot_ac": "Q6P073", "gene_name": "Ube2j2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q6P073", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P073" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q6P073", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P073" } ] } ] }, { "uniprot_ac": "Q6PAV2", "gene_name": "Herc4", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6PAV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PAV2" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q6PAV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PAV2" } ] } ] }, { "uniprot_ac": "Q6PCX9", "gene_name": "Trim37", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6PCX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PCX9" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q6PCX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PCX9" } ] } ] }, { "uniprot_ac": "Q6PDX6", "gene_name": "Rnf220", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6PDX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PDX6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q6PDX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PDX6" } ] } ] }, { "uniprot_ac": "Q6WKZ8", "gene_name": "Ubr2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6WKZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6WKZ8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q6WKZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6WKZ8" } ] } ] }, { "uniprot_ac": "Q6ZPJ3", "gene_name": "Ube2o", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6ZPJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZPJ3" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "Q6ZPJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZPJ3" } ] } ] }, { "uniprot_ac": "Q6ZWZ2", "gene_name": "Ube2r2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q6ZWZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZWZ2" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q6ZWZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZWZ2" } ] } ] }, { "uniprot_ac": "Q71FD5", "gene_name": "Znrf2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q71FD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q71FD5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q71FD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q71FD5" } ] } ] }, { "uniprot_ac": "Q7TMY8", "gene_name": "Huwe1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q7TMY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TMY8" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q7TMY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TMY8" } ] } ] }, { "uniprot_ac": "Q7TPV2", "gene_name": "Dzip3", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q7TPV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TPV2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q7TPV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TPV2" } ] } ] }, { "uniprot_ac": "Q7TSS2", "gene_name": "Ube2q1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q7TSS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TSS2" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q7TSS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TSS2" } ] } ] }, { "uniprot_ac": "Q80TR8", "gene_name": "Dcaf1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q80TR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80TR8" } ] } ] }, { "uniprot_ac": "Q80U04", "gene_name": "Pja2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q80U04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80U04" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q80U04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80U04" } ] } ] }, { "uniprot_ac": "Q80U95", "gene_name": "Ube3c", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q80U95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80U95" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q80U95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80U95" } ] } ] }, { "uniprot_ac": "Q80WG7", "gene_name": "Trim36", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q80WG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80WG7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q80WG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80WG7" } ] } ] }, { "uniprot_ac": "Q80X56", "gene_name": "Trim69", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q80X56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80X56" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q80X56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80X56" } ] } ] }, { "uniprot_ac": "Q80ZI6", "gene_name": "Lrsam1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q80ZI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80ZI6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q80ZI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80ZI6" } ] } ] }, { "uniprot_ac": "Q810I2", "gene_name": "Trim50", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q810I2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q810I2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q810I2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q810I2" } ] } ] }, { "uniprot_ac": "Q8BH75", "gene_name": "Rnf41", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8BH75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BH75" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8BH75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BH75" } ] } ] }, { "uniprot_ac": "Q8BKD6", "gene_name": "Rnf144b", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "Q8BKD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BKD6" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "Q8BKD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BKD6" } ] } ] }, { "uniprot_ac": "Q8BM54", "gene_name": "Mylip", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8BM54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BM54" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8BM54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BM54" } ] } ] }, { "uniprot_ac": "Q8BX13", "gene_name": "Ube3d", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8BX13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BX13" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q8BX13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BX13" } ] } ] }, { "uniprot_ac": "Q8BZZ3", "gene_name": "Wwp1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8BZZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BZZ3" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q8BZZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BZZ3" } ] } ] }, { "uniprot_ac": "Q8C432", "gene_name": "Rnf182", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8C432", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8C432" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8C432", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8C432" } ] } ] }, { "uniprot_ac": "Q8C7M3", "gene_name": "Trim9", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8C7M3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8C7M3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8C7M3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8C7M3" } ] } ] }, { "uniprot_ac": "Q8C863", "gene_name": "Itch", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8C863", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8C863" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q8C863", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8C863" } ] } ] }, { "uniprot_ac": "Q8CCJ3", "gene_name": "Ufl1", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "Q8CCJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CCJ3" } ] } ] }, { "uniprot_ac": "Q8CDU6", "gene_name": "Hectd2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8CDU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CDU6" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q8CDU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CDU6" } ] } ] }, { "uniprot_ac": "Q8CFI0", "gene_name": "Nedd4l", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8CFI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CFI0" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q8CFI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CFI0" } ] }, { "ec_number": "2.3.2.36", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine.", "evidence": [ { "id": "Q8CFI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CFI0" } ] }, { "ec_number": "2.3.2.36", "activity": "", "evidence": [ { "id": "Q8CFI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CFI0" } ] } ] }, { "uniprot_ac": "Q8CFI2", "gene_name": "Cdc34", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8CFI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CFI2" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q8CFI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CFI2" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q8CFI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CFI2" } ] } ] }, { "uniprot_ac": "Q8CH72", "gene_name": "Trim32", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8CH72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CH72" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8CH72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CH72" } ] } ] }, { "uniprot_ac": "Q8CHG5", "gene_name": "Arel1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8CHG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CHG5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q8CHG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CHG5" } ] } ] }, { "uniprot_ac": "Q8K2Z8", "gene_name": "Ube2q2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q8K2Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K2Z8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q8K2Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K2Z8" } ] } ] }, { "uniprot_ac": "Q8R516", "gene_name": "Mib2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8R516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R516" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8R516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R516" } ] } ] }, { "uniprot_ac": "Q8VDW4", "gene_name": "Ube2w", "activity": [ { "ec_number": "2.3.2.25", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-N-terminal-amino acid = [E1 ubiquitin-activating enzyme]-L-cysteine + N-terminal-ubiquitinyl-[acceptor protein].", "evidence": [ { "id": "Q8VDW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VDW4" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q8VDW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VDW4" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q8VDW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VDW4" } ] } ] }, { "uniprot_ac": "Q8VEM1", "gene_name": "Rnf130", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8VEM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VEM1" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8VEM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VEM1" } ] } ] }, { "uniprot_ac": "Q8VIG6", "gene_name": "Traip", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8VIG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VIG6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8VIG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VIG6" } ] } ] }, { "uniprot_ac": "Q91V17", "gene_name": "Znrf1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q91V17", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91V17" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q91V17", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91V17" } ] } ] }, { "uniprot_ac": "Q91W82", "gene_name": "Ube2e2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q91W82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91W82" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q91W82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91W82" } ] } ] }, { "uniprot_ac": "Q91YL2", "gene_name": "Rnf126", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q91YL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91YL2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q91YL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91YL2" } ] } ] }, { "uniprot_ac": "Q921J4", "gene_name": "Ube2s", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q921J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q921J4" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q921J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q921J4" } ] } ] }, { "uniprot_ac": "Q922B6", "gene_name": "Traf7", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q922B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q922B6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q922B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q922B6" } ] } ] }, { "uniprot_ac": "Q925F4", "gene_name": "Ubox5", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q925F4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q925F4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q925F4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q925F4" } ] } ] }, { "uniprot_ac": "Q99KR6", "gene_name": "Rnf34", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q99KR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99KR6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q99KR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99KR6" } ] } ] }, { "uniprot_ac": "Q99ML9", "gene_name": "Rnf111", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q99ML9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99ML9" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q99ML9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99ML9" } ] } ] }, { "uniprot_ac": "Q99PQ2", "gene_name": "Trim11", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q99PQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99PQ2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q99PQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99PQ2" } ] } ] }, { "uniprot_ac": "Q9CQE0", "gene_name": "Rnf138", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9CQE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CQE0" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9CQE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CQE0" } ] } ] }, { "uniprot_ac": "Q9CR50", "gene_name": "Rchy1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9CR50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CR50" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9CR50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CR50" } ] } ] }, { "uniprot_ac": "Q9CUN6", "gene_name": "Smurf1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9CUN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CUN6" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q9CUN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CUN6" } ] } ] }, { "uniprot_ac": "Q9CY34", "gene_name": "Ube2f", "activity": [ { "ec_number": "2.3.2.34", "activity": "[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.", "evidence": [ { "id": "Q9CY34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CY34" } ] }, { "ec_number": "2.3.2.34", "activity": "", "evidence": [ { "id": "Q9CY34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CY34" } ] } ] }, { "uniprot_ac": "Q9D074", "gene_name": "Mgrn1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9D074", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D074" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9D074", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D074" } ] } ] }, { "uniprot_ac": "Q9D0C1", "gene_name": "Rnf115", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9D0C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D0C1" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9D0C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D0C1" } ] } ] }, { "uniprot_ac": "Q9D1C1", "gene_name": "Ube2c", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9D1C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D1C1" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q9D1C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D1C1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q9D1C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D1C1" } ] } ] }, { "uniprot_ac": "Q9DBK7", "gene_name": "Uba7", "activity": [ { "ec_number": "6.2.1.45", "activity": "ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.", "evidence": [ { "id": "Q9DBK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBK7" } ] }, { "ec_number": "6.2.1.45", "activity": "", "evidence": [ { "id": "Q9DBK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBK7" } ] } ] }, { "uniprot_ac": "Q9DBU5", "gene_name": "Rnf6", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9DBU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBU5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9DBU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBU5" } ] } ] }, { "uniprot_ac": "Q9ES34", "gene_name": "Ube3b", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9ES34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ES34" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q9ES34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ES34" } ] } ] }, { "uniprot_ac": "Q9ESN2", "gene_name": "Trim39", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9ESN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ESN2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9ESN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ESN2" } ] } ] }, { "uniprot_ac": "Q9ET26", "gene_name": "Rnf114", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9ET26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ET26" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9ET26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ET26" } ] } ] }, { "uniprot_ac": "Q9JI90", "gene_name": "Rnf14", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "Q9JI90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JI90" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "Q9JI90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JI90" } ] } ] }, { "uniprot_ac": "Q9JIY2", "gene_name": "Cbll1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9JIY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JIY2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9JIY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JIY2" } ] } ] }, { "uniprot_ac": "Q9JJZ4", "gene_name": "Ube2j1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q9JJZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JJZ4" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q9JJZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JJZ4" } ] } ] }, { "uniprot_ac": "Q9QXP6", "gene_name": "Mkrn1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9QXP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QXP6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9QXP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QXP6" } ] } ] }, { "uniprot_ac": "Q9QZR0", "gene_name": "Rnf25", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9QZR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QZR0" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9QZR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QZR0" } ] } ] }, { "uniprot_ac": "Q9QZS2", "gene_name": "Rnf4", "activity": [ { "ec_number": 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