{ "uniprot_canonical_ac": "Q9I816-1", "uniprot_ac": "Q9I816", "uniprot_id": "OR19A_DROME", "mass": { "chemical_mass": 44228.0, "monoisotopic_mass": 44228.0 }, "refseq": { "ac": "NP_525013", "name": "odorant receptor 19a", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_525013" }, "gene_names": [ { "name": "Or19a", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q9I816", "id": "Q9I816" }, { "name": "19a; 19A.1; CG18859; Dmel\\CG18859; DmOr19a; DOR37; OR19a; Or19a-1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_525013", "id": "NP_525013" }, { "name": "CG18859", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9I816", "id": "Q9I816" }, { "name": "Or19a", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_525013", "id": "NP_525013" } ], "protein_names": [ { "name": "Odorant receptor 19a", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q9I816" }, { "name": "CG18859-PB; Or19a-PB", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_525013", "id": "NP_525013" }, { "name": "odorant receptor 19a", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_525013", "id": "NP_525013" } ], "function": [ { "annotation": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the preference for citrus fruits for oviposition, especially through the response to valencene, the primary ligand of Or19a. Larvae growing on citrus fruits suffer a reduced risk of parasitism since endoparasitoid wasps that parasitize larvae are strongly repelled by the smell of citrus, as well as by valencene.", "evidence": [ { "database": "UniProtKB", "id": "Q9I816", "url": "https://www.uniprot.org/uniprot/Q9I816#function" }, { "database": "PubMed", "id": "24316206", "url": "https://glygen.org/publication/PubMed/24316206" }, { "database": "PubMed", "id": "16615896", "url": "https://glygen.org/publication/PubMed/16615896" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q9I816", "url": "https://www.uniprot.org/uniprot/Q9I816" } ], "common_name": "Fruit fly" } ], "gene": [ { "name": "Or19a", "url": "https://www.uniprot.org/uniprot/Q9I816", "locus": { "chromosome": "X", "start_pos": 20141819, "end_pos": 20143188, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "FBgn0041626", "url": "https://www.ensembl.org/id/FBgn0041626" } ] } } ], "crossref": [ { "id": "FBgn0041626", "url": "https://bgee.org/?page=gene&gene_id=FBgn0041626", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "FBgn0041626", "url": "https://flybase.org/reports/FBgn0041626", "database": "FlyBase", "categories": [ "Organism-specific" ] }, { "id": "59214", "url": "https://www.ncbi.nlm.nih.gov/gene/59214", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q9I816", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q9I816*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR004117", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004117", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dme:Dmel_CG18859", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG18859", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "HSATWEC", "url": "https://omabrowser.org/oma/group/HSATWEC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "3382147at2759", "url": "http://www.orthodb.org/?query=3382147at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21137", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21137", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21137:SF35", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21137:SF35", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02949", "url": "http://pfam.xfam.org/family/PF02949", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q9I816", "url": "http://purl.obolibrary.org/obo/PR_Q9I816", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_525013", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_525013", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q9I816", "url": "https://www.uniprot.org/uniprot/Q9I816", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9I816-1", "url": "https://www.uniprot.org/uniprot/Q9I816-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MDISKVDSTRALVNHWRIFRIMGIHPPGKRTFWGRHYTAYSMVWNVTFHICIWVSFSVNLLQSNSLETFCESLCVTMPHTLYMLKLINVRRMRGQMISSHWLLRLLDKRLGCDDERQIIMAGIERAEFIFRTIFRGLACTVVLGIIYISASSEPTLMYPTWIPWNWRDSTSAYLATAMLHTTALMANATLVLNLSSYPGTYLILVSVHTKALALRVSKLGYGAPLPAVRMQAILVGYIHDHQIILRLFKSLERSLSMTCFLQFFSTACAQCTICYFLLFGNVGIMRFMNMLFLLVILTTETLLLCYTAELPCKEGESLLTAVYSCNWLSQSVNFRRLLLLMLARCQIPMILVSGVIVPISMKTFTVMIKGAYTMLTLLNEIRKTSLE", "length": 387, "header": "sp|Q9I816-1|OR19A_DROME Isoform 1 of Odorant receptor 19a OS=Drosophila melanogaster OX=7227 GN=Or19a PE=2 SV=2 CANONICAL=Q9I816-1" }, "isoforms": [ { "isoform_ac": "Q9I816-1", "url": "", "sequence": { "sequence": "MDISKVDSTRALVNHWRIFRIMGIHPPGKRTFWGRHYTAYSMVWNVTFHICIWVSFSVNLLQSNSLETFCESLCVTMPHTLYMLKLINVRRMRGQMISSHWLLRLLDKRLGCDDERQIIMAGIERAEFIFRTIFRGLACTVVLGIIYISASSEPTLMYPTWIPWNWRDSTSAYLATAMLHTTALMANATLVLNLSSYPGTYLILVSVHTKALALRVSKLGYGAPLPAVRMQAILVGYIHDHQIILRLFKSLERSLSMTCFLQFFSTACAQCTICYFLLFGNVGIMRFMNMLFLLVILTTETLLLCYTAELPCKEGESLLTAVYSCNWLSQSVNFRRLLLLMLARCQIPMILVSGVIVPISMKTFTVMIKGAYTMLTLLNEIRKTSLE", "length": 387, "header": "sp|Q9I816-1|OR19A_DROME Isoform 1 of Odorant receptor 19a OS=Drosophila melanogaster OX=7227 GN=Or19a PE=2 SV=2 CANONICAL=Q9I816-1" }, "locus": { "chromosome": "X", "start_pos": 20143188, "end_pos": 20141822, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0070029", "url": "https://www.ensembl.org/id/FBtr0070029" }, { "database": "Ensembl Peptide", "id": "FBpp0070028", "url": "https://www.ensembl.org/id/FBpp0070028" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "The genome sequence of Drosophila melanogaster.", "journal": "Science", "date": "2000", "authors": "Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA, Galle RF, George RA, Lewis SE, Richards S, Ashburner M, Henderson SN, Sutton GG, Wortman JR, Yandell MD, Zhang Q, Chen LX, Brandon RC, Rogers YH, Blazej RG, Champe M, Pfeiffer BD, Wan KH, Doyle C, Baxter EG, Helt G, Nelson CR, Gabor GL, Abril JF, Agbayani A, An HJ, Andrews-Pfannkoch C, Baldwin D, Ballew RM, Basu A, Baxendale J, Bayraktaroglu L, Beasley EM, Beeson KY, Benos PV, Berman BP, Bhandari D, Bolshakov S, Borkova D, Botchan MR, Bouck J, Brokstein P, Brottier P, Burtis KC, Busam DA, Butler H, Cadieu E, Center A, Chandra I, Cherry JM, Cawley S, Dahlke C, Davenport LB, Davies P, de Pablos B, Delcher A, Deng Z, Mays AD, Dew I, Dietz SM, Dodson K, Doup LE, Downes M, Dugan-Rocha S, Dunkov BC, Dunn P, Durbin KJ, Evangelista CC, Ferraz C, Ferriera S, Fleischmann W, Fosler C, Gabrielian AE, Garg NS, Gelbart WM, Glasser K, Glodek A, Gong F, Gorrell JH, Gu Z, Guan P, Harris M, Harris NL, Harvey D, Heiman TJ, Hernandez JR, Houck J, Hostin D, Houston KA, Howland TJ, Wei MH, Ibegwam C, Jalali M, Kalush F, Karpen GH, Ke Z, Kennison JA, Ketchum KA, Kimmel BE, Kodira CD, Kraft C, Kravitz S, Kulp D, Lai Z, Lasko P, Lei Y, Levitsky AA, Li J, Li Z, Liang Y, Lin X, Liu X, Mattei B, McIntosh TC, McLeod MP, McPherson D, Merkulov G, Milshina NV, Mobarry C, Morris J, Moshrefi A, Mount SM, Moy M, Murphy B, Murphy L, Muzny DM, Nelson DL, Nelson DR, Nelson KA, Nixon K, Nusskern DR, Pacleb JM, Palazzolo M, Pittman GS, Pan S, Pollard J, Puri V, Reese MG, Reinert K, Remington K, Saunders RD, Scheeler F, Shen H, Shue BC, Siden-Kiamos I, Simpson M, Skupski MP, Smith T, Spier E, Spradling AC, Stapleton M, Strong R, Sun E, Svirskas R, Tector C, Turner R, Venter E, Wang AH, Wang X, Wang ZY, Wassarman DA, Weinstock GM, Weissenbach J, Williams SM, WoodageT, Worley KC, Wu D, Yang S, Yao QA, Ye J, Yeh RF, Zaveri JS, Zhan M, Zhang G, Zhao Q, Zheng L, Zheng XH, Zhong FN, Zhong W, Zhou X, Zhu S, Zhu X, Smith HO, Gibbs RA, Myers EW, Rubin GM, Venter JC", "evidence": [ { "database": "UniProtKB", "id": "Q9I816", "url": "https://www.uniprot.org/uniprot/Q9I816" } ], "reference": [ { "type": "PubMed", "id": "10731132", "url": "https://glygen.org/publication/PubMed/10731132" } ] }, { "title": "An olfactory sensory map in the fly brain.", "journal": "Cell", "date": "2000", "authors": "Axel R., Wong A.M., Vosshall L.B.", "evidence": [ { "database": "UniProtKB", "id": "Q9I816", "url": "https://www.uniprot.org/uniprot/Q9I816" } ], "reference": [ { "type": "PubMed", "id": "10943836", "url": "https://glygen.org/publication/PubMed/10943836" } ] }, { "title": "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.", "journal": "Genome Biol.", "date": "2002", "authors": "Misra S, Crosby MA, Mungall CJ, Matthews BB, Campbell KS, Hradecky P, Huang Y, Kaminker JS, Millburn GH, Prochnik SE, Smith CD, Tupy JL, Whitfied EJ, Bayraktaroglu L, Berman BP, Bettencourt BR, Celniker SE, de Grey AD, Drysdale RA, Harris NL, Richter J, Russo S, Schroeder AJ, Shu SQ, Stapleton M, Yamada C, Ashburner M, Gelbart WM, Rubin GM, Lewis SE", "evidence": [ { "database": "UniProtKB", "id": "Q9I816", "url": "https://www.uniprot.org/uniprot/Q9I816" } ], "reference": [ { "type": "PubMed", "id": "12537572", "url": "https://glygen.org/publication/PubMed/12537572" } ] }, { "title": "Coding of odors by a receptor repertoire.", "journal": "Cell", "date": "2006", "authors": "Carlson J.R., Hallem E.A.", "evidence": [ { "database": "UniProtKB", "id": "Q9I816", "url": "https://www.uniprot.org/uniprot/Q9I816" } ], "reference": [ { "type": "PubMed", "id": "16615896", "url": "https://glygen.org/publication/PubMed/16615896" } ] }, { "title": "Olfactory preference for egg laying on citrus substrates in Drosophila.", "journal": "Curr. Biol.", "date": "2013", "authors": "Bown D., Sachse S., Dweck H.K., Ebrahim S.A., Hansson B.S., Hillbur Y., Kromann S., Stensmyr M.C.", "evidence": [ { "database": "UniProtKB", "id": "Q9I816", "url": "https://www.uniprot.org/uniprot/Q9I816" } ], "reference": [ { "type": "PubMed", "id": "24316206", "url": "https://glygen.org/publication/PubMed/24316206" } ] } ], "pathway": [ { "id": "dme:Dmel_CG18859", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG18859", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q9I816", "url": "https://www.uniprot.org/uniprot/Q9I816" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q9I816", "url": "https://www.uniprot.org/uniprot/Q9I816" } ], "pmid": "" }, { "name": "dendrite membrane", "id": "GO:0032590", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032590", "evidence": [ { "database": "UniProtKB", "id": "Q9I816", "url": "https://www.uniprot.org/uniprot/Q9I816" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "signal transduction", "id": "GO:0007165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "evidence": [ { "database": "UniProtKB", "id": "Q9I816", "url": "https://www.uniprot.org/uniprot/Q9I816" } ], "pmid": "" }, { "name": "detection of chemical stimulus involved in sensory perception of smell", "id": "GO:0050911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050911", "evidence": [ { "database": "UniProtKB", "id": "Q9I816", "url": "https://www.uniprot.org/uniprot/Q9I816" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "olfactory receptor activity", "id": "GO:0004984", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004984", "evidence": [ { "database": "UniProtKB", "id": "Q9I816", "url": "https://www.uniprot.org/uniprot/Q9I816" } ], "pmid": "" }, { "name": "odorant binding", "id": "GO:0005549", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005549", "evidence": [ { "database": "UniProtKB", "id": "Q9I816", "url": "https://www.uniprot.org/uniprot/Q9I816" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 187, "end_pos": 189, "annotation": "n_glycosylation_sequon" }, { "start_pos": 193, "end_pos": 195, "annotation": "n_glycosylation_sequon" }, { "start_pos": 45, "end_pos": 47, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { 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