{ "uniprot_canonical_ac": "Q9ET22-1", "uniprot_ac": "Q9ET22", "uniprot_id": "DPP2_MOUSE", "mass": { "chemical_mass": 56254.0, "monoisotopic_mass": 56254.0 }, "refseq": { "ac": "NP_114031", "name": "dipeptidyl peptidase 2 isoform 1 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114031" }, "gene_names": [ { "name": "Dpp7", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q9ET22", "id": "Q9ET22" }, { "name": "Dpp2; DPPII; QPP", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114031", "id": "NP_114031" }, { "name": "Dpp2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9ET22", "id": "Q9ET22" }, { "name": "Dpp7", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114031", "id": "NP_114031" }, { "name": "Qpp", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9ET22", "id": "Q9ET22" } ], "protein_names": [ { "name": "Dipeptidyl peptidase 2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q9ET22" }, { "name": "3.4.14.2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9ET22" }, { "name": "DPP II", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9ET22" }, { "name": "Dipeptidyl aminopeptidase II", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9ET22" }, { "name": "Dipeptidyl peptidase 7", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9ET22" }, { "name": "Dipeptidyl peptidase II", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9ET22" }, { "name": "Quiescent cell proline dipeptidase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9ET22" }, { "name": "dipeptidyl peptidase 2 isoform 1 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114031", "id": "NP_114031" }, { "name": "dipeptidyl peptidase II; dipeptidyl peptidase 2; DPP II; dipeptidyl aminopeptidase II; quiescent cell proline dipeptidase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114031", "id": "NP_114031" } ], "function": [ { "annotation": "Data show that an increase in food intake in DPP2 kd mice, which was associated with a significant increase in adipose tissue mass and enhanced liver steatosis but no difference in body weight.", "evidence": [ { "database": "RefSeq", "id": "NP_114031", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114031" }, { "database": "PubMed", "id": "19819973", "url": "https://glygen.org/publication/PubMed/19819973" } ] }, { "annotation": "Gene deficiency results in Th17 differentiation and peripheral T cells hyperactivation upon TCR stimulation", "evidence": [ { "database": "RefSeq", "id": "NP_114031", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114031" }, { "database": "PubMed", "id": "21469121", "url": "https://glygen.org/publication/PubMed/21469121" } ] }, { "annotation": "KLF2 and TOB1 activate the mouse Dpp2 promoter.", "evidence": [ { "database": "RefSeq", "id": "NP_114031", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114031" }, { "database": "PubMed", "id": "18555530", "url": "https://glygen.org/publication/PubMed/18555530" } ] }, { "annotation": "Plays an important role in the degradation of some oligopeptides.", "evidence": [ { "database": "UniProtKB", "id": "Q9ET22", "url": "https://www.uniprot.org/uniprot/Q9ET22#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q9ET22", "url": "https://www.uniprot.org/uniprot/Q9ET22" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Dpp7", "url": "https://www.uniprot.org/uniprot/Q9ET22", "locus": { "chromosome": "2", "start_pos": 25242288, "end_pos": 25246371, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000026958", "url": "https://www.ensembl.org/id/ENSMUSG00000026958" } ] } } ], "crossref": [ { "id": "ENSMUSG00000026958", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000026958", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "CHEMBL3259501", "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL3259501", "database": "ChEMBL", "categories": [ "Other" ] }, { "id": "83768", "url": "https://www.ncbi.nlm.nih.gov/gene/83768", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "2256", "url": "https://glyconnect.expasy.org/browser/proteins/2256", "database": "GlyConnect", "categories": [ "Glycan", "Glycoproteomics" ] }, { "id": "GPDB0007537", "url": "https://acgg.asia/db/gpdb/symbol/GPDB0007537", "database": "GlycoProtDB", "categories": [ "Glycoproteomics" ] }, { "id": "IPR008758", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008758", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029058", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029058", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042269", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042269", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:83768", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:83768", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1933213", "url": "http://www.informatics.jax.org/marker/MGI:1933213", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "MLAAYMR", "url": "https://omabrowser.org/oma/group/MLAAYMR/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5488375at2759", "url": "http://www.orthodb.org/?query=5488375at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11010", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11010", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11010:SF107", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11010:SF107", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF05577", "url": "http://pfam.xfam.org/family/PF05577", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q9ET22", "url": "http://purl.obolibrary.org/obo/PR_Q9ET22", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6798695", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_114031", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114031", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q9ET22", "url": "https://www.uniprot.org/uniprot/Q9ET22", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9ET22-1", "url": "https://www.uniprot.org/uniprot/Q9ET22-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNFHPCYPVDHGVPSWILVLLLSLGLCNLQARADRVLDPDFHENYFEQYMDHFNFESFGNKTFGQRFLVSDKFWKMGEGPIFFYTGNEGDIWSFANNSGFMVELAAQQEALLVFAEHRYYGKSLPFGVQSTQRGYTQLLTVEQALADFAVLLQALRQDLGVHDAPTIAFGGSYGGMLSAYMRMKYPHLVAGALAASAPVVAVAGLGDSYQFFRDVTADFYGQSPKCAQAVRDAFQQIKDLFLQGAYDTISQNFGTCQSLSSPKDLTQLFGFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCQRLLNEGQRIMGLRALAGLVYNSSGTEPCYDIYRLYQSCADPTGCGTGSDARAWDYQACTEINLTFDSNNVTDMFPEIPFSEELRQQYCLDTWGVWPRQDWLQTSFWGGDLKAASNIIFSNGDLDPWAGGGIQSNLSTSVIAVTIQGGAHHLDLRASNSEDPPSVVEVRKLESTLIREWVAAARLKQPAMPRWPGPKKQHPSR", "length": 506, "header": "sp|Q9ET22-1|DPP2_MOUSE Isoform 1 of Dipeptidyl peptidase 2 OS=Mus musculus OX=10090 GN=Dpp7 PE=1 SV=2 CANONICAL=Q9ET22-1" }, "isoforms": [ { "isoform_ac": "Q9ET22-1", "url": "", "sequence": { "sequence": "MNFHPCYPVDHGVPSWILVLLLSLGLCNLQARADRVLDPDFHENYFEQYMDHFNFESFGNKTFGQRFLVSDKFWKMGEGPIFFYTGNEGDIWSFANNSGFMVELAAQQEALLVFAEHRYYGKSLPFGVQSTQRGYTQLLTVEQALADFAVLLQALRQDLGVHDAPTIAFGGSYGGMLSAYMRMKYPHLVAGALAASAPVVAVAGLGDSYQFFRDVTADFYGQSPKCAQAVRDAFQQIKDLFLQGAYDTISQNFGTCQSLSSPKDLTQLFGFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCQRLLNEGQRIMGLRALAGLVYNSSGTEPCYDIYRLYQSCADPTGCGTGSDARAWDYQACTEINLTFDSNNVTDMFPEIPFSEELRQQYCLDTWGVWPRQDWLQTSFWGGDLKAASNIIFSNGDLDPWAGGGIQSNLSTSVIAVTIQGGAHHLDLRASNSEDPPSVVEVRKLESTLIREWVAAARLKQPAMPRWPGPKKQHPSR", "length": 506, "header": "sp|Q9ET22-1|DPP2_MOUSE Isoform 1 of Dipeptidyl peptidase 2 OS=Mus musculus OX=10090 GN=Dpp7 PE=1 SV=2 CANONICAL=Q9ET22-1" }, "locus": { "chromosome": "2", "start_pos": 25246339, "end_pos": 25242434, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000028332", "url": "https://www.ensembl.org/id/ENSMUST00000028332" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000028332", "url": "https://www.ensembl.org/id/ENSMUSP00000028332" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G84820NF", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 325, "start_aa": "Asn", "end_pos": 325, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn325", "evidence": [ { "id": "2256", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2256" }, { "id": "30899004", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30899004" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 325, "start_aa": "Asn", "end_pos": 325, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn325", "evidence": [ { "id": "Q9ET22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ET22#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 366, "start_aa": "Asn", "end_pos": 366, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn366", "evidence": [ { "id": "Q9ET22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ET22#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 373, "start_aa": "Asn", "end_pos": 373, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn373", "evidence": [ { "id": "Q9ET22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ET22#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 438, "start_aa": "Asn", "end_pos": 438, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn438", "evidence": [ { "id": "Q9ET22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ET22#ptm_processing" } ] }, { "glytoucan_ac": "G14669DU", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 60, "start_aa": "Asn", "end_pos": 60, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn60", "evidence": [ { "id": "2256", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2256" }, { "id": "30899004", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30899004" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 60, "start_aa": "Asn", "end_pos": 60, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn60", "evidence": [ { "id": "Q9ET22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ET22#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 96, "start_aa": "Asn", "end_pos": 96, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn96", "evidence": [ { "id": "Q9ET22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ET22#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted", "glycoprotein_reported", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Lymphocyte quiescence factor Dpp2 is transcriptionally activated by KLF2 and TOB1.", "journal": "Molecular immunology", "date": "2008", "authors": "Bista P, Mele DA, Baez DV, Huber BT", "evidence": [ { "database": "RefSeq", "id": "NP_114031", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114031" } ], "reference": [ { "type": "PubMed", "id": "18555530", "url": "https://glygen.org/publication/PubMed/18555530" } ] }, { "title": "Neurogenin 3-specific dipeptidyl peptidase-2 deficiency causes impaired glucose tolerance, insulin resistance, and visceral obesity.", "journal": "Endocrinology", "date": "2009", "authors": "Danilova OV, Tai AK, Mele DA, Beinborn M, Leiter AB, Greenberg AS, Perfield JW 2nd, Defuria J, Singru PS, Lechan RM, Huber BT", "evidence": [ { "database": "RefSeq", "id": "NP_114031", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114031" } ], "reference": [ { "type": "PubMed", "id": "19819973", "url": "https://glygen.org/publication/PubMed/19819973" } ] }, { "title": "Th17 differentiation is the default program for DPP2-deficient T-cell differentiation.", "journal": "European journal of immunology", "date": "2011", "authors": "Mele DA, Sampson JF, Huber BT", "evidence": [ { "database": "RefSeq", "id": "NP_114031", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114031" } ], "reference": [ { "type": "PubMed", "id": "21469121", "url": "https://glygen.org/publication/PubMed/21469121" } ] }, { "title": "Capturing site-specific heterogeneity with large-scale N-glycoproteome analysis.", "journal": "Nature communications", "date": "2019", "authors": "Riley NM, Hebert AS, Westphall MS, Coon JJ", "evidence": [ { "database": "GlyConnect", "id": "2256", "url": "https://glyconnect.expasy.org/browser/proteins/2256" } ], "reference": [ { "type": "PubMed", "id": "30899004", "url": "https://glygen.org/publication/PubMed/30899004" } ] } ], "pathway": [ { "id": "mmu:83768", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:83768", "resource": "KEGG Pathway" }, { "id": "R-MMU-6798695", "name": "Neutrophil degranulation", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" } ], "orthologs": [ { "uniprot_canonical_ac": "Q9EPB1-1", "protein_name": "Dipeptidyl peptidase 2", "gene_name": "Dpp7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGLHPCSPVDHGVPSWVLVLLLTLGLCSLQATADSVLDPDFRENYFEQYMDHFNFESFSNKTFGQRFLVSDKFWKMGEGPIFFYTGNEGDIWSLANNSGFIVELAAQQEALLVFAEHRYYGKSLPFGVQSTQRGYTQLLTVEQALADFAVLLQALRHNLGVQDAPTIAFGGSYGGMLSAYMRMKYPHLVAGALAASAPVIAVAGLGNPDQFFRDVTADFYGQSPKCAQAVRDAFQQIKDLFLQGAYDTISQNFGTCQSLSSPKDLTQLFGFARNAFTVLAMMDYPYPTNFLGPLPANPVKVGCERLLSEGQRIMGLRALAGLVYNSSGMEPCFDIYQMYQSCADPTGCGTGSNARAWDYQACTEINLTFDSNNVTDMFPEIPFSDELRQQYCLDTWGVWPRPDWLQTSFWGGDLKAASNIIFSNGDLDPWAGGGIQRNLSTSIIAVTIQGGAHHLDLRASNSEDPPSVVEVRKLEATLIREWVAAARLKQPAEAQWPGPK", "length": 500 }, "evidence": [ { "id": "45236535", "url": "http://www.informatics.jax.org/homology/45236535", "database": "MGI" }, { "id": "Q9ET22", "url": "https://omabrowser.org/oma/group/Q9ET22/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9UHL4-1", "protein_name": "Dipeptidyl peptidase 2", "gene_name": "DPP7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQQPALRGGPRLSL", "length": 492 }, "evidence": [ { "id": "45236535", "url": "http://www.informatics.jax.org/homology/45236535", "database": "MGI" }, { "id": "Q9ET22", "url": "https://omabrowser.org/oma/group/Q9ET22/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "dipeptidyl-peptidase activity", "id": "GO:0008239", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008239", "evidence": [ { "database": "UniProtKB", "id": "Q9ET22", "url": "https://www.uniprot.org/uniprot/Q9ET22" } ], "pmid": "" }, { "name": "aminopeptidase activity", "id": "GO:0004177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004177", "evidence": [ { "database": "UniProtKB", "id": "Q9ET22", "url": "https://www.uniprot.org/uniprot/Q9ET22" } ], "pmid": "" }, { "name": "serine-type peptidase activity", "id": "GO:0008236", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008236", "evidence": [ { "database": "UniProtKB", "id": "Q9ET22", "url": "https://www.uniprot.org/uniprot/Q9ET22" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q9ET22", "url": "https://www.uniprot.org/uniprot/Q9ET22" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "Q9ET22", "url": "https://www.uniprot.org/uniprot/Q9ET22" } ], "pmid": "" }, { "name": "intracellular membrane-bounded organelle", "id": "GO:0043231", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", "evidence": [ { "database": "UniProtKB", "id": "Q9ET22", "url": "https://www.uniprot.org/uniprot/Q9ET22" } ], "pmid": "" }, { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "Q9ET22", "url": "https://www.uniprot.org/uniprot/Q9ET22" } ], "pmid": "" }, { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "Q9ET22", "url": "https://www.uniprot.org/uniprot/Q9ET22" } ], "pmid": "" }, { "name": "vesicle", "id": "GO:0031982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031982", "evidence": [ { "database": "UniProtKB", "id": "Q9ET22", "url": "https://www.uniprot.org/uniprot/Q9ET22" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "Q9ET22", "url": "https://www.uniprot.org/uniprot/Q9ET22" } ], "pmid": "" }, { "name": "protein catabolic process", "id": "GO:0030163", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030163", "evidence": [ { "database": "UniProtKB", "id": "Q9ET22", "url": "https://www.uniprot.org/uniprot/Q9ET22" } ], "pmid": "" }, { "name": "lysosomal protein catabolic process", "id": "GO:1905146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905146", "evidence": [ { "database": "UniProtKB", "id": "Q9ET22", "url": "https://www.uniprot.org/uniprot/Q9ET22" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 325, "end_pos": 327, "annotation": "n_glycosylation_sequon" }, { "start_pos": 366, "end_pos": 368, "annotation": "n_glycosylation_sequon" }, { "start_pos": 373, "end_pos": 375, "annotation": "n_glycosylation_sequon" }, { "start_pos": 438, "end_pos": 440, "annotation": "n_glycosylation_sequon" }, { "start_pos": 60, "end_pos": 62, "annotation": "n_glycosylation_sequon" }, { "start_pos": 96, "end_pos": 98, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-MMU-6798751", "name": "Exocytosis of azurophil granule lumen proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, azurophil granule lumen", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q99KR8-1", "Q99LJ1-1", "Q61096-1", "P07146-1", "Q9R0T7-1", "Q3UP87-1", "Q9ET22-1", "P11247-1", "P50096-1", "P28867-1", "Q9DCN2-1", "O08709-1", "Q91V92-1", "P50429-1", "Q61176-1", "Q8BWM0-1", "Q8CI94-1", "Q01853-1", "Q62465-1", "P20060-1", "Q08642-1", "C0HKG6-1", "O35292-1", "Q91W90-1", "C0HKG5-1", "Q922K9-1", "P50428-1", "P12265-1", "P23780-1", "P28293-1", "P97821-1", "Q571E4-1", "Q9Z0L8-1", "P16675-1", "P63085-1", "Q8BFS6-1", "Q8CC86-1", "P51569-1", "Q64191-1", "P97425-1", "P97426-1", "Q8BFR4-1", "O09159-1", "P08905-1", "Q9QUK9-1" ], "evidence": [ { "id": "R-MMU-6798751", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6798751" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "C0HKG5", "gene_name": "Rnaset2a", "activity": [ { "ec_number": "4.6.1.19", "activity": "a ribonucleotidyl-ribonucleotide-RNA + H2O = a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + H(+).", "evidence": [ { "id": "C0HKG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/C0HKG5" } ] }, { "ec_number": "4.6.1.19", "activity": "", "evidence": [ { "id": "C0HKG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/C0HKG5" } ] } ] }, { "uniprot_ac": "C0HKG6", "gene_name": "Rnaset2b", "activity": [ { "ec_number": "4.6.1.19", "activity": "a ribonucleotidyl-ribonucleotide-RNA + H2O = a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + H(+).", "evidence": [ { "id": "C0HKG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/C0HKG6" } ] }, { "ec_number": "4.6.1.19", "activity": "", "evidence": [ { "id": "C0HKG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/C0HKG6" } ] } ] }, { "uniprot_ac": "O08709", "gene_name": "Prdx6", "activity": [ { "ec_number": "1.11.1.27", "activity": "a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O.", "evidence": [ { "id": "O08709", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08709" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "O08709", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08709" } ] }, { "ec_number": "2.3.1.23", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA.", "evidence": [ { "id": "O08709", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08709" } ] }, { "ec_number": "1.11.1.27", "activity": "", "evidence": [ { "id": "O08709", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08709" } ] } ] }, { "uniprot_ac": "O09159", "gene_name": "Man2b1", "activity": [ { "ec_number": "3.2.1.24", "activity": "Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.", "evidence": [ { "id": "O09159", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09159" } ] }, { "ec_number": "3.2.1.24", "activity": "", "evidence": [ { "id": "O09159", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09159" } ] } ] }, { "uniprot_ac": "O35292", "gene_name": "Rnase2b", "activity": [ { "ec_number": "4.6.1.18", "activity": "an [RNA] containing cytidine + H2O = an [RNA]-3'-cytidine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA].", "evidence": [ { "id": "O35292", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35292" } ] }, { "ec_number": "4.6.1.18", "activity": "", "evidence": [ { "id": "O35292", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35292" } ] } ] }, { "uniprot_ac": "P07146", "gene_name": "Prss2", "activity": [ { "ec_number": "3.4.21.4", "activity": "Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.", "evidence": [ { "id": "P07146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07146" } ] }, { "ec_number": "3.4.21.4", "activity": "", "evidence": [ { "id": "P07146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07146" } ] } ] }, { "uniprot_ac": "P08905", "gene_name": "Lyz2", "activity": [ { "ec_number": "3.2.1.17", "activity": "Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.", "evidence": [ { "id": "P08905", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08905" } ] }, { "ec_number": "3.2.1.17", "activity": "", "evidence": [ { "id": "P08905", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08905" } ] } ] }, { "uniprot_ac": "P11247", "gene_name": "Mpo", "activity": [ { "ec_number": "1.11.2.2", "activity": "chloride + H(+) + H2O2 = H2O + hypochlorous acid.", "evidence": [ { "id": "P11247", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11247" } ] }, { "ec_number": "1.11.2.2", "activity": "", "evidence": [ { "id": "P11247", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11247" } ] } ] }, { "uniprot_ac": "P12265", "gene_name": "Gusb", "activity": [ { "ec_number": "3.2.1.31", "activity": "a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate.", "evidence": [ { "id": "P12265", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12265" } ] }, { "ec_number": "3.2.1.31", "activity": "", "evidence": [ { "id": "P12265", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12265" } ] } ] }, { "uniprot_ac": "P16675", "gene_name": "Ctsa", "activity": [ { "ec_number": "3.4.16.5", "activity": "Release of a C-terminal amino acid with broad specificity.", "evidence": [ { "id": "P16675", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16675" } ] }, { "ec_number": "3.4.16.5", "activity": "", "evidence": [ { "id": "P16675", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16675" } ] }, { "ec_number": "3.4.16.-", "activity": "", "evidence": [ { "id": "P16675", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16675" } ] } ] }, { "uniprot_ac": "P20060", "gene_name": "Hexb", "activity": [ { "ec_number": "3.2.1.52", "activity": "Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.", "evidence": [ { "id": "P20060", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20060" } ] }, { "ec_number": "3.2.1.52", "activity": "", "evidence": [ { "id": "P20060", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20060" } ] } ] }, { "uniprot_ac": "P23780", "gene_name": "Glb1", "activity": [ { "ec_number": "3.2.1.23", "activity": "Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.", "evidence": [ { "id": "P23780", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23780" } ] }, { "ec_number": "3.2.1.23", "activity": "", "evidence": [ { "id": "P23780", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23780" } ] } ] }, { "uniprot_ac": "P28293", "gene_name": "Ctsg", "activity": [ { "ec_number": "3.4.21.20", "activity": "Specificity similar to chymotrypsin C.", "evidence": [ { "id": "P28293", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28293" } ] }, { "ec_number": "3.4.21.20", "activity": "", "evidence": [ { "id": "P28293", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28293" } ] } ] }, { "uniprot_ac": "P28867", "gene_name": "Prkcd", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P28867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28867" } ] }, { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P28867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28867" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P28867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28867" } ] } ] }, { "uniprot_ac": "P50096", "gene_name": "Impdh1", "activity": [ { "ec_number": "1.1.1.205", "activity": "H2O + IMP + NAD(+) = H(+) + NADH + XMP.", "evidence": [ { "id": "P50096", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50096" } ] }, { "ec_number": "1.1.1.205", "activity": "", "evidence": [ { "id": "P50096", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50096" } ] } ] }, { "uniprot_ac": "P50428", "gene_name": "Arsa", "activity": [ { "ec_number": "3.1.6.8", "activity": "H2O + N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + sulfate.", "evidence": [ { "id": "P50428", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50428" } ] }, { "ec_number": "3.1.6.8", "activity": "", "evidence": [ { "id": "P50428", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50428" } ] } ] }, { "uniprot_ac": "P50429", "gene_name": "Arsb", "activity": [ { "ec_number": "3.1.6.12", "activity": "Hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate.", "evidence": [ { "id": "P50429", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50429" } ] }, { "ec_number": "3.1.6.12", "activity": "", "evidence": [ { "id": "P50429", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50429" } ] } ] }, { "uniprot_ac": "P51569", "gene_name": "Gla", "activity": [ { "ec_number": "3.2.1.-", "activity": "", "evidence": [ { "id": "P51569", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51569" } ] }, { "ec_number": "3.2.1.22", "activity": "globoside Gb3Cer (d18:1(4E)) + H2O = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + D-galactose.", "evidence": [ { "id": "P51569", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51569" } ] }, { "ec_number": "3.2.1.22", "activity": "", "evidence": [ { "id": "P51569", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51569" } ] } ] }, { "uniprot_ac": "P63085", "gene_name": "Mapk1", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P63085", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63085" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P63085", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63085" } ] } ] }, { "uniprot_ac": "P97425", "gene_name": "Ear2", "activity": [ { "ec_number": "3.1.27.-", "activity": "", "evidence": [ { "id": "P97425", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97425" } ] } ] }, { "uniprot_ac": "P97426", "gene_name": "Ear1", "activity": [ { "ec_number": "3.1.27.-", "activity": "", "evidence": [ { "id": "P97426", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97426" } ] } ] }, { "uniprot_ac": "P97821", "gene_name": "Ctsc", "activity": [ { "ec_number": "3.4.14.1", "activity": "Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, except when Xaa is Arg or Lys, or Yaa or Zaa is Pro.", "evidence": [ { "id": "P97821", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97821" } ] }, { "ec_number": "3.4.14.1", "activity": "", "evidence": [ { "id": "P97821", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97821" } ] } ] }, { "uniprot_ac": "Q01853", "gene_name": "Vcp", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q01853", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01853" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "Q01853", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01853" } ] } ] }, { "uniprot_ac": "Q08642", "gene_name": "Padi2", "activity": [ { "ec_number": "3.5.3.15", "activity": "H2O + L-arginyl-[protein] = L-citrullyl-[protein] + NH4(+).", "evidence": [ { "id": "Q08642", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08642" } ] }, { "ec_number": "3.5.3.15", "activity": "", "evidence": [ { "id": "Q08642", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08642" } ] } ] }, { "uniprot_ac": "Q3UP87", "gene_name": "Elane", "activity": [ { "ec_number": "3.4.21.37", "activity": "Hydrolysis of proteins, including elastin. Preferential cleavage: Val-|-Xaa > Ala-|-Xaa.", "evidence": [ { "id": "Q3UP87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UP87" } ] }, { "ec_number": "3.4.21.37", "activity": "", "evidence": [ { "id": "Q3UP87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UP87" } ] } ] }, { "uniprot_ac": "Q571E4", "gene_name": "Galns", "activity": [ { "ec_number": "3.1.6.4", "activity": "Hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate.", "evidence": [ { "id": "Q571E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q571E4" } ] }, { "ec_number": "3.1.6.4", "activity": "", "evidence": [ { "id": "Q571E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q571E4" } ] } ] }, { "uniprot_ac": "Q61096", "gene_name": "Prtn3", "activity": [ { "ec_number": "3.4.21.76", "activity": "Hydrolysis of proteins, including elastin, by preferential cleavage: -Ala-|-Xaa- > -Val-|-Xaa-.", "evidence": [ { "id": "Q61096", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61096" } ] }, { "ec_number": "3.4.21.76", "activity": "", "evidence": [ { "id": "Q61096", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61096" } ] } ] }, { "uniprot_ac": "Q61176", "gene_name": "Arg1", "activity": [ { "ec_number": "3.5.3.1", "activity": "H2O + L-arginine = L-ornithine + urea.", "evidence": [ { "id": "Q61176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61176" } ] }, { "ec_number": "3.5.3.1", "activity": "", "evidence": [ { "id": "Q61176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61176" } ] } ] }, { "uniprot_ac": "Q62465", "gene_name": "Vat1", "activity": [ { "ec_number": "1.-.-.-", "activity": "", "evidence": [ { "id": "Q62465", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62465" } ] } ] }, { "uniprot_ac": "Q64191", "gene_name": "Aga", "activity": [ { "ec_number": "3.5.1.26", "activity": "H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine = H(+) + L-aspartate + N-acetyl-beta-D-glucosaminylamine.", "evidence": [ { "id": "Q64191", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64191" } ] }, { "ec_number": "3.5.1.26", "activity": "", "evidence": [ { "id": "Q64191", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64191" } ] } ] }, { "uniprot_ac": "Q8BFR4", "gene_name": "Gns", "activity": [ { "ec_number": "3.1.6.14", "activity": "Hydrolysis of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate.", "evidence": [ { "id": "Q8BFR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BFR4" } ] }, { "ec_number": "3.1.6.14", "activity": "", "evidence": [ { "id": "Q8BFR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BFR4" } ] } ] }, { "uniprot_ac": "Q8BFS6", "gene_name": 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"ec_number": "3.2.1.51", "activity": "", "evidence": [ { "id": "Q99LJ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99LJ1" } ] } ] }, { "uniprot_ac": "Q9DCN2", "gene_name": "Cyb5r3", "activity": [ { "ec_number": "1.6.2.2", "activity": "2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + H(+) + NAD(+).", "evidence": [ { "id": "Q9DCN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DCN2" } ] }, { "ec_number": "1.6.2.2", "activity": "", "evidence": [ { "id": "Q9DCN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DCN2" } ] } ] }, { "uniprot_ac": "Q9ET22", "gene_name": "Dpp7", "activity": [ { "ec_number": "3.4.14.2", "activity": "Release of an N-terminal dipeptide, Xaa-Yaa-|-, preferentially when Yaa is Ala or Pro. 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