{ "uniprot_canonical_ac": "Q9ESW4-1", "uniprot_ac": "Q9ESW4", "uniprot_id": "AGK_MOUSE", "mass": { "chemical_mass": 46976.0, "monoisotopic_mass": 46976.0 }, "refseq": { "ac": "NP_076027", "name": "acylglycerol kinase, mitochondrial precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076027" }, "gene_names": [ { "name": "Agk", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q9ESW4", "id": "Q9ESW4" }, { "name": "2610037M15Rik; 6720408I04Rik; Mulk", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076027", "id": "NP_076027" }, { "name": "Agk", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076027", "id": "NP_076027" }, { "name": "Mulk", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9ESW4", "id": "Q9ESW4" } ], "protein_names": [ { "name": "Acylglycerol kinase, mitochondrial", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q9ESW4" }, { "name": "2.7.1.107", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9ESW4" }, { "name": "2.7.1.138", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9ESW4" }, { "name": "2.7.1.94", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9ESW4" }, { "name": "MuLK", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9ESW4" }, { "name": "Multi-substrate lipid kinase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9ESW4" }, { "name": "Multiple substrate lipid kinase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9ESW4" }, { "name": "acylglycerol kinase, mitochondrial precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076027", "id": "NP_076027" }, { "name": "multiple substrate lipid kinase; acylglycerol kinase, mitochondrial; multi-substrate lipid kinase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076027", "id": "NP_076027" } ], "function": [ { "annotation": "AGK promotes cell proliferation and tumorigenicity in breast cancer via suppression of the FOXO1. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_076027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076027" }, { "database": "PubMed", "id": "24886245", "url": "https://glygen.org/publication/PubMed/24886245" } ] }, { "annotation": "Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively (PubMed:15252046). Phosphorylates ceramide but not sphingosine (PubMed:15252046). Phosphorylates 1,2-dioleoylglycerol more rapidly than 2,3-dioleoylglycerol (PubMed:18004883). Independently of its lipid kinase activity, acts as a component of the TIM22 complex (By similarity). The TIM22 complex mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane by forming a twin-pore translocase that uses the membrane potential as the external driving force (By similarity). In the TIM22 complex, required for the import of a subset of metabolite carriers into mitochondria, such as ANT1/SLC25A4 and SLC25A24, while it is not required for the import of TIMM23 (By similarity). Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q9ESW4", "url": "https://www.uniprot.org/uniprot/Q9ESW4#function" }, { "database": "UniProtKB", "id": "Q53H12", "url": "https://www.uniprot.org/uniprot/Q53H12#function" }, { "database": "PubMed", "id": "15252046", "url": "https://glygen.org/publication/PubMed/15252046" }, { "database": "PubMed", "id": "18004883", "url": "https://glygen.org/publication/PubMed/18004883" } ] }, { "annotation": "The role of AGK in thrombocytopoiesis and possible therapeutic strategies.", "evidence": [ { "database": "RefSeq", "id": "NP_076027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076027" }, { "database": "PubMed", "id": "32202634", "url": "https://glygen.org/publication/PubMed/32202634" } ] } ], "disease": [ { "disease_id": "DOID:0080132", "recommended_name": { "id": "DOID:0080132", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080132", "name": "Sengers syndrome", "description": "A mitochondrial DNA depletion syndrome that is characterized by congenital cataracts, hypertrophic cardiomyopathy, skeletal myopathy, exercise intolerance, and lactic acidosis, but normal mental development, and has_material_basis_in autosomal recessive inheritance of homozygous or compound heterozygous mutation in the acylglycerol kinase gene on chromosome 7q34." }, "synonyms": [ { "id": "DOID:0080132", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080132", "name": "mitochondrial DNA depletion syndrome 10", "description": "" }, { "id": "DOID:0080132", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0080132", "name": "mitochondrial DNA depletion syndrome 10 (cardiomyopathic type)", "description": "" }, { "id": "MONDO:0008922", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008922", "name": "Sengers syndrome", "description": "Congenital cataract - hypertrophic cardiomyopathy - mitochrondrial myopathy (CCM) is a mitochondrial disease characterized by cataracts, hypertrophic cardiomyopathy, muscle weakness and lactic acidosis after exercise." }, { "id": "MONDO:0008922", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008922", "name": "Sengers syndrome", "description": "" }, { "id": "MONDO:0008922", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008922", "name": "mitochondrial DNA depletion syndrome 10", "description": "" }, { "id": "MONDO:0008922", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008922", "name": "cardiomyopathic mitochondrial DNA depletion syndrome 10", "description": "" }, { "id": "MONDO:0008922", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008922", "name": "cardiomyopathy and cataract", "description": "" }, { "id": "MONDO:0008922", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008922", "name": "cataract and cardiomyopathy", "description": "" }, { "id": "MONDO:0008922", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008922", "name": "congenital cataract-hypertrophic cardiomyopathy-mitochondrial myopathy syndrome", "description": "" }, { "id": "MONDO:0008922", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008922", "name": "mitochondrial DNA depletion syndrome 10 (Cardiomyopathic type)", "description": "" }, { "id": "MIM:212350", "resource": "MIM", "url": "https://www.omim.org/entry/212350", "name": "Mitochondrial DNA depletion syndrome 10", "description": "Mitochondrial DNA depletion syndrome 10" } ], "evidence": [ { "id": "0080132", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0080132" } ] }, { "disease_id": "DOID:0110245", "recommended_name": { "id": "DOID:0110245", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110245", "name": "cataract 38", "description": "A cataract that has_material_basis_in homozygous mutation in the AGK gene on chromosome 7q34." }, "synonyms": [ { "id": "DOID:0110245", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110245", "name": "CATC5", "description": "" }, { "id": "DOID:0110245", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110245", "name": "CTRCT38", "description": "" }, { "id": "DOID:0110245", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110245", "name": "autosomal recessive congenital cataract 5", "description": "" }, { "id": "MONDO:0013859", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013859", "name": "cataract 38", "description": "Any early-onset non-syndromic cataract in which the cause of the disease is a mutation in the AGK gene." }, { "id": "MONDO:0013859", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013859", "name": "AGK early-onset non-syndromic cataract", "description": "" }, { "id": "MONDO:0013859", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013859", "name": "CATC5", "description": "" }, { "id": "MONDO:0013859", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013859", "name": "CTRCT38", "description": "" }, { "id": "MONDO:0013859", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013859", "name": "autosomal recessive congenital cataract 5", "description": "" }, { "id": "MONDO:0013859", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013859", "name": "cataract 38", "description": "" }, { "id": "MONDO:0013859", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013859", "name": "cataract 38, autosomal recessive", "description": "" }, { "id": "MONDO:0013859", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013859", "name": "cataract type 38", "description": "" }, { "id": "MONDO:0013859", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013859", "name": "early-onset non-syndromic cataract caused by mutation in AGK", "description": "" }, { "id": "MONDO:0013859", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013859", "name": "cataract, autosomal recessive congenital 5", "description": "" }, { "id": "MIM:614691", "resource": "MIM", "url": "https://www.omim.org/entry/614691", "name": "Cataract 38", "description": "Cataract 38" } ], "evidence": [ { "id": "0110245", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0110245" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q9ESW4", "url": "https://www.uniprot.org/uniprot/Q9ESW4" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Agk", "url": "https://www.uniprot.org/uniprot/Q9ESW4", "locus": { "chromosome": "6", "start_pos": 40373696, "end_pos": 40302106, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000029916", "url": "https://www.ensembl.org/id/ENSMUSG00000029916" } ] } } ], "crossref": [ { "id": "ENSMUSG00000029916", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000029916", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "2.7.1.94", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.7.1.94&UniProtAcc=Q9ESW4", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "69923", "url": "https://www.ncbi.nlm.nih.gov/gene/69923", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001206", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001206", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016064", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016064", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017438", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017438", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045579", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045579", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:69923", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:69923", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1917173", "url": "http://www.informatics.jax.org/marker/MGI:1917173", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "PHTCPEG", "url": "https://omabrowser.org/oma/group/PHTCPEG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2907389at2759", "url": "http://www.orthodb.org/?query=2907389at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12358", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12358", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12358:SF54", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12358:SF54", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00781", "url": "http://pfam.xfam.org/family/PF00781", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF19712", "url": "http://pfam.xfam.org/family/PF19712", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q9ESW4", "url": "http://purl.obolibrary.org/obo/PR_Q9ESW4", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-1483206", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1483206", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_076027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076027", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "10272", "url": "https://www.rhea-db.org/rhea/10272", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "17929", "url": "https://www.rhea-db.org/rhea/17929", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "19293", "url": "https://www.rhea-db.org/rhea/19293", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "33747", "url": "https://www.rhea-db.org/rhea/33747", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "40327", "url": "https://www.rhea-db.org/rhea/40327", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "41079", "url": "https://www.rhea-db.org/rhea/41079", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "43308", "url": "https://www.rhea-db.org/rhea/43308", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "43312", "url": "https://www.rhea-db.org/rhea/43312", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "43316", "url": "https://www.rhea-db.org/rhea/43316", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "43328", "url": "https://www.rhea-db.org/rhea/43328", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A0J9YU24", "url": "https://www.uniprot.org/uniprot/A0A0J9YU24", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0J9YU24-1", "url": "https://www.uniprot.org/uniprot/A0A0J9YU24-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9ESW4", "url": "https://www.uniprot.org/uniprot/Q9ESW4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9ESW4-1", "url": "https://www.uniprot.org/uniprot/Q9ESW4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9ESW4-2", "url": "https://www.uniprot.org/uniprot/Q9ESW4-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTAFFKTLRNHWKKTTAGLCLLTWGGHWLYGKHCDNLLRRAACQEAQVFGNQLIPPNAQVKKATVFLNPAACKGKARTLFEKNAAPILHLSGMDVTVVKTDYEGQAKKLLELMESTDVIIVAGGDGTLQEVVTGVLRRTDEATFSKIPIGFIPLGQTSSLSHTLFAESGNKVQHITDATLAIVKGETVPLDVLQIKGEKEQPVYAMTGLRWGSFRDAGVKVSKYWYLGPLKTKAAHFFSTLQEWPQTHQASISYTGPRERPPIEPEETPPRPSLYRRILRRLASFWAQPQDASSREVSPEVWKDVQLSTIELSITTRNTQLDLMSKEDFMNICIEPDTVSKGDFIIIGSKKVRDPGLRAAGTECLQASHCTLVLPEGTEGSFSIDSEEYEAMPVEVKLLPRKLRFFCDPRKREQMLPSTSQ", "length": 421, "header": "sp|Q9ESW4-1|AGK_MOUSE Isoform 1 of Acylglycerol kinase, mitochondrial OS=Mus musculus OX=10090 GN=Agk PE=1 SV=1 CANONICAL=Q9ESW4-1" }, "isoforms": [ { "isoform_ac": "A0A0J9YU24-1", "url": "", "sequence": { "sequence": "MTAFFKTLRNHWKKTTAGLCLLTWGGHWLYGKHCDNLLRRAACQEAQVFGNQLIPPNAQVKKATVFLNPAACKGYFSL", "length": 78, "header": "tr|A0A0J9YU24-1|AGK_MOUSE Computationally mapped isoform of Acylglycerol kinase, mitochondrial OS=Mus musculus OX=10090 GN=Agk PE=1 SV=1 CANONICAL=Q9ESW4-1" }, "locus": { "chromosome": "6", "start_pos": 40329379, "end_pos": 40306433, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000200715.2", "url": "https://www.ensembl.org/id/ENSMUST00000200715.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000143971.2", "url": "https://www.ensembl.org/id/ENSMUSP00000143971.2" } ] } }, { "isoform_ac": "Q9ESW4-1", "url": "", "sequence": { "sequence": "MTAFFKTLRNHWKKTTAGLCLLTWGGHWLYGKHCDNLLRRAACQEAQVFGNQLIPPNAQVKKATVFLNPAACKGKARTLFEKNAAPILHLSGMDVTVVKTDYEGQAKKLLELMESTDVIIVAGGDGTLQEVVTGVLRRTDEATFSKIPIGFIPLGQTSSLSHTLFAESGNKVQHITDATLAIVKGETVPLDVLQIKGEKEQPVYAMTGLRWGSFRDAGVKVSKYWYLGPLKTKAAHFFSTLQEWPQTHQASISYTGPRERPPIEPEETPPRPSLYRRILRRLASFWAQPQDASSREVSPEVWKDVQLSTIELSITTRNTQLDLMSKEDFMNICIEPDTVSKGDFIIIGSKKVRDPGLRAAGTECLQASHCTLVLPEGTEGSFSIDSEEYEAMPVEVKLLPRKLRFFCDPRKREQMLPSTSQ", "length": 421, "header": "sp|Q9ESW4-1|AGK_MOUSE Isoform 1 of Acylglycerol kinase, mitochondrial OS=Mus musculus OX=10090 GN=Agk PE=1 SV=1 CANONICAL=Q9ESW4-1" }, "locus": { "chromosome": "6", "start_pos": 40372793, "end_pos": 40306433, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000031977", "url": "https://www.ensembl.org/id/ENSMUST00000031977" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000031977", "url": "https://www.ensembl.org/id/ENSMUSP00000031977" } ] } }, { "isoform_ac": "Q9ESW4-2", "url": "", "sequence": { "sequence": "MTAFFKTLRNHWKKTTAGLCLLTWGGHWLYGKHCDNLLRRAACQEAQVFGNQLIPPNAQVKKATVFLNPAACKGKARTLFEKNAAPILHLSGMDVTVVKTDYEGQAKKLLELMESTDVIIVAGGDGTLQEVVTGVLRRTDEATFSKIPIGFIPLGQTSSLSHTLFAESGNKVQ", "length": 173, "header": "sp|Q9ESW4-2|AGK_MOUSE Isoform 2 of Acylglycerol kinase, mitochondrial OS=Mus musculus OX=10090 GN=Agk PE=1 SV=1 CANONICAL=Q9ESW4-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "MuLK, a eukaryotic multi-substrate lipid kinase.", "journal": "J. Biol. Chem.", "date": "2004", "authors": "Waggoner DW, Johnson LB, Mann PC, Morris V, Guastella J, Bajjalieh SM", "evidence": [ { "database": "UniProtKB", "id": "Q9ESW4", "url": "https://www.uniprot.org/uniprot/Q9ESW4" } ], "reference": [ { "type": "PubMed", "id": "15252046", "url": "https://glygen.org/publication/PubMed/15252046" } ] }, { "title": "Further characterization of mammalian ceramide kinase: substrate delivery and (stereo)specificity, tissue distribution, and subcellular localization studies.", "journal": "J. Lipid Res.", "date": "2006", "authors": "Van Overloop H, Gijsbers S, Van Veldhoven PP", "evidence": [ { "database": "UniProtKB", "id": "Q9ESW4", "url": "https://www.uniprot.org/uniprot/Q9ESW4" } ], "reference": [ { "type": "PubMed", "id": "16269826", "url": "https://glygen.org/publication/PubMed/16269826" } ] }, { "title": "Substrate chirality and specificity of diacylglycerol kinases and the multisubstrate lipid kinase.", "journal": "Biochemistry", "date": "2007", "authors": "Epand RM, Shulga YV, Timmons HC, Perri AL, Belani JD, Perinpanathan K, Johnson-McIntire LB, Bajjalieh S, Dicu AO, Elias C, Rychnovsky SD, Topham MK", "evidence": [ { "database": "UniProtKB", "id": "Q9ESW4", "url": "https://www.uniprot.org/uniprot/Q9ESW4" } ], "reference": [ { "type": "PubMed", "id": "18004883", "url": "https://glygen.org/publication/PubMed/18004883" } ] }, { "title": "Acylglycerol kinase promotes cell proliferation and tumorigenicity in breast cancer via suppression of the FOXO1 transcription factor.", "journal": "Molecular cancer", "date": "2014", "authors": "Wang X, Lin C, Zhao X, Liu A, Zhu J, Li X, Song L", "evidence": [ { "database": "RefSeq", "id": "NP_076027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076027" } ], "reference": [ { "type": "PubMed", "id": "24886245", "url": "https://glygen.org/publication/PubMed/24886245" } ] }, { "title": "The role of AGK in thrombocytopoiesis and possible therapeutic strategies.", "journal": "Blood", "date": "2020", "authors": "Jiang H, Yu Z, Ding N, Yang M, Zhang L, Fan X, Zhou Y, Zou Q, Hou J, Zheng J, Zhang L, Xu Y, Liu J", "evidence": [ { "database": "RefSeq", "id": "NP_076027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076027" } ], "reference": [ { "type": "PubMed", "id": "32202634", "url": "https://glygen.org/publication/PubMed/32202634" } ] } ], "pathway": [ { "id": "mmu:69923", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:69923", "resource": "KEGG Pathway" }, { "id": "R-MMU-1483206", "name": "Glycerophospholipid biosynthesis", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1483206", "resource": "Reactome", "description": "Glycerophospholipid biosynthesis" } ], "orthologs": [ { "uniprot_canonical_ac": "Q53H12-1", "protein_name": "Acylglycerol kinase, mitochondrial", "gene_name": "AGK", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTVFFKTLRNHWKKTTAGLCLLTWGGHWLYGKHCDNLLRRAACQEAQVFGNQLIPPNAQVKKATVFLNPAACKGKARTLFEKNAAPILHLSGMDVTIVKTDYEGQAKKLLELMENTDVIIVAGGDGTLQEVVTGVLRRTDEATFSKIPIGFIPLGETSSLSHTLFAESGNKVQHITDATLAIVKGETVPLDVLQIKGEKEQPVFAMTGLRWGSFRDAGVKVSKYWYLGPLKIKAAHFFSTLKEWPQTHQASISYTGPTERPPNEPEETPVQRPSLYRRILRRLASYWAQPQDALSQEVSPEVWKDVQLSTIELSITTRNNQLDPTSKEDFLNICIEPDTISKGDFITIGSRKVRNPKLHVEGTECLQASQCTLLIPEGAGGSFSIDSEEYEAMPVEVKLLPRKLQFFCDPRKREQMLTSPTQ", "length": 422 }, "evidence": [ { "id": "45236267", "url": "http://www.informatics.jax.org/homology/45236267", "database": "MGI" }, { "id": "Q9ESW4", "url": "https://omabrowser.org/oma/group/Q9ESW4/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "lipid phosphorylation", "id": "GO:0046834", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046834", "evidence": [ { "database": "UniProtKB", "id": "Q9ESW4", "url": "https://www.uniprot.org/uniprot/Q9ESW4" } ], "pmid": "" }, { "name": "protein insertion into mitochondrial inner membrane", "id": "GO:0045039", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045039", "evidence": [ { "database": "UniProtKB", "id": "Q9ESW4", "url": "https://www.uniprot.org/uniprot/Q9ESW4" } ], "pmid": "" }, { "name": "ceramide biosynthetic process", "id": "GO:0046513", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046513", "evidence": [ { "database": "UniProtKB", "id": "Q9ESW4", "url": "https://www.uniprot.org/uniprot/Q9ESW4" } ], "pmid": "" }, { "name": "glycerolipid metabolic process", "id": "GO:0046486", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046486", "evidence": [ { "database": "UniProtKB", "id": "Q9ESW4", "url": "https://www.uniprot.org/uniprot/Q9ESW4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "lipid kinase activity", "id": "GO:0001727", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001727", "evidence": [ { "database": "UniProtKB", "id": "Q9ESW4", "url": "https://www.uniprot.org/uniprot/Q9ESW4" } ], "pmid": "" }, { "name": "ceramide kinase activity", "id": "GO:0001729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001729", "evidence": [ { "database": "UniProtKB", "id": "Q9ESW4", "url": "https://www.uniprot.org/uniprot/Q9ESW4" } ], "pmid": "" }, { "name": "ATP-dependent diacylglycerol kinase activity", "id": "GO:0004143", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004143", "evidence": [ { "database": "UniProtKB", "id": "Q9ESW4", "url": "https://www.uniprot.org/uniprot/Q9ESW4" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q9ESW4", "url": "https://www.uniprot.org/uniprot/Q9ESW4" } ], "pmid": "" }, { "name": "acylglycerol kinase activity", "id": "GO:0047620", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047620", "evidence": [ { "database": "UniProtKB", "id": "Q9ESW4", "url": "https://www.uniprot.org/uniprot/Q9ESW4" } ], "pmid": "" }, { "name": "dihydroceramide kinase activity", "id": "GO:0102773", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0102773", "evidence": [ { "database": "UniProtKB", "id": "Q9ESW4", "url": "https://www.uniprot.org/uniprot/Q9ESW4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q9ESW4", "url": "https://www.uniprot.org/uniprot/Q9ESW4" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q9ESW4", "url": "https://www.uniprot.org/uniprot/Q9ESW4" } ], "pmid": "" }, { "name": "mitochondrial intermembrane space", "id": "GO:0005758", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005758", "evidence": [ { "database": "UniProtKB", "id": "Q9ESW4", "url": "https://www.uniprot.org/uniprot/Q9ESW4" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q9ESW4", "url": "https://www.uniprot.org/uniprot/Q9ESW4" } ], "pmid": "" }, { "name": "mitochondrial membrane", "id": "GO:0031966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031966", "evidence": [ { "database": "UniProtKB", "id": "Q9ESW4", "url": "https://www.uniprot.org/uniprot/Q9ESW4" } ], "pmid": "" }, { "name": "TIM22 mitochondrial import inner membrane insertion complex", "id": "GO:0042721", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042721", "evidence": [ { "database": "UniProtKB", "id": "Q9ESW4", "url": "https://www.uniprot.org/uniprot/Q9ESW4" } ], "pmid": "" }, { "name": "intracellular membrane-bounded organelle", "id": "GO:0043231", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", "evidence": [ { "database": "UniProtKB", "id": "Q9ESW4", "url": "https://www.uniprot.org/uniprot/Q9ESW4" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10272", "name": "", "equation": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O08560-1", "F1LZW2-1", "D3ZEY4-1", "P51556-1", "P49620-1", "P49621-1", "A0A096UWG9-1", "F1MAB7-1", "D3ZSZ6-1", "F1M5T2-1", "D3Z9L0-1", "P52429-1", "Q53H12-1", "Q86XP1-1", "O75912-1", "P52824-1", "P49619-1", "Q16760-1", "Q5KSL6-1", "Q9Y6T7-1", "P23743-1", "Q13574-2", "Q91WG7-1", "D3YXJ0-1", "D3YWQ0-1", "Q9ESW4-1", "Q9R1C6-1", "O88673-1", "Q80UP3-1", "Q6P5E8-1", "Q6NS52-1", "E9PUQ8-1", "F6UUZ3-1", "P34125-1", "Q9VL10-1", "Q01583-4", "Q09103-1", "A8JQ65-1", "A0A0B4KHZ4-1", "Q7K579-1" ], "evidence": [ { "id": "10272", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10272" } ] }, { "id": "17929", "name": "", "equation": "an N-acylsphing-4-enine + ATP = ADP + an N-acylsphing-4-enine 1-phosphate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3Z9L0-1", "Q53H12-1", "Q8TCT0-1", "Q8K4Q7-1", "Q9ESW4-1", "Q9VL10-1" ], "evidence": [ { "id": "17929", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17929" } ] }, { "id": "19293", "name": "", "equation": "a monoacylglycerol + ATP = ADP + H(+) + monoacyl-sn-glycero-3-phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3Z9L0-1", "Q53H12-1", "Q9ESW4-1", "Q9VL10-1" ], "evidence": [ { "id": "19293", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/19293" } ] }, { "id": "33747", "name": "", "equation": "a 1-acyl-sn-glycerol + ATP = a 1-acyl-sn-glycero-3-phosphate + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3Z9L0-1", "Q53H12-1", "Q9ESW4-1", "Q9VL10-1" ], "evidence": [ { "id": "33747", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/33747" } ] }, { "id": "40327", "name": "", "equation": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O08560-1", "P51556-1", "P49620-1", "P49621-1", "A0A096UWG9-1", "F1LZW2-1", "F1MAB7-1", "D3ZSZ6-1", "F1M5T2-1", "D3ZEY4-1", "D3Z9L0-1", "Q53H12-1", "O75912-1", "P52824-1", "P23743-1", "P52429-1", "Q86XP1-1", "Q9Y6T7-1", "Q16760-1", "P49619-1", "Q5KSL6-1", "Q13574-2", "Q9ESW4-1", "O88673-1", "Q80UP3-1", "D3YWQ0-1", "D3YXJ0-1", "Q91WG7-1", "Q9R1C6-1", "Q6P5E8-1", "Q6NS52-1", "E9PUQ8-1", "F6UUZ3-1", "Q9VL10-1" ], "evidence": [ { "id": "40327", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40327" } ] }, { "id": "41079", "name": "", "equation": "1-(9Z-octadecenoyl)-sn-glycerol + ATP = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3Z9L0-1", "Q53H12-1", "Q9ESW4-1", "Q9VL10-1" ], "evidence": [ { "id": "41079", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/41079" } ] }, { "id": "43308", "name": "", "equation": "1-hexadecanoyl-sn-glycerol + ATP = 1-hexadecanoyl-sn-glycero-3-phosphate + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3Z9L0-1", "Q53H12-1", "Q9ESW4-1", "Q9VL10-1" ], "evidence": [ { "id": "43308", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/43308" } ] }, { "id": "43312", "name": "", "equation": "ATP + N-(hexanoyl)sphing-4-enine = ADP + H(+) + N-hexanoylsphing-4-enine 1-phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3Z9L0-1", "Q8TCT0-1", "Q53H12-1", "Q8K4Q7-1", "Q9ESW4-1", "Q9VL10-1" ], "evidence": [ { "id": "43312", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/43312" } ] }, { "id": "43316", "name": "", "equation": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + ATP = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3Z9L0-1", "Q53H12-1", "Q9ESW4-1", "Q9VL10-1" ], "evidence": [ { "id": "43316", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/43316" } ] }, { "id": "43328", "name": "", "equation": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3Z9L0-1", "Q53H12-1", "Q9ESW4-1", "Q9VL10-1" ], "evidence": [ { "id": "43328", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/43328" } ] }, { "id": "R-MMU-5696074", "name": "AGK:Mg2+ phosphorylates MAG, DAG", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial intermembrane space, mitochondrial outer membrane", "input_participant_list": [ "R-ALL-5696069" ], "output_participant_list": [ "R-ALL-5696026" ], "enzyme_list": [ "Q9ESW4-1" ], "evidence": [ { "id": "R-MMU-5696074", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5696074" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-5696026", "participant_name": "ADP [mitochondrial intermembrane space]", "crossref": [ { "id": "C00008", "database": "COMPOUND", "url": "" }, { "id": "456216", "database": "ChEBI", "url": "" }, { "id": "000012360703", "database": "ZINC", "url": "" }, { "id": "C00008", "database": "COMPOUND", "url": "" }, { "id": "456216", "database": "ChEBI", "url": "" }, { "id": "000012360703", "database": "ZINC", "url": "" }, { "id": "C00008", "database": "COMPOUND", "url": "" }, { "id": "456216", "database": "ChEBI", "url": "" }, { "id": "000012360703", "database": "ZINC", "url": "" }, { "id": "456216", "database": "ChEBI", "url": "" }, { "id": "000012360703", "database": "ZINC", "url": "" }, { "id": "C00008", "database": "COMPOUND", "url": "" }, { "id": "C00008", "database": "COMPOUND", "url": "" }, { "id": "456216", "database": "ChEBI", "url": "" }, { "id": "000012360703", "database": "ZINC", "url": "" } ] }, { "participant_id": "R-ALL-5696069", "participant_name": "ATP [mitochondrial intermembrane space]", "crossref": [ { "id": "000004261765", "database": "ZINC", "url": "" }, { "id": "C00002", "database": "COMPOUND", "url": "" }, { "id": "30616", "database": "ChEBI", "url": "" }, { "id": "000004261765", "database": "ZINC", "url": "" }, { "id": "C00002", "database": "COMPOUND", "url": "" }, { "id": "30616", "database": "ChEBI", "url": "" }, { "id": "30616", "database": "ChEBI", "url": "" }, { "id": "000004261765", "database": "ZINC", "url": "" }, { "id": "C00002", "database": "COMPOUND", "url": "" }, { "id": "C00002", "database": "COMPOUND", "url": "" }, { "id": "30616", "database": "ChEBI", "url": "" }, { "id": "000004261765", "database": "ZINC", "url": "" }, { "id": "30616", "database": "ChEBI", "url": "" }, { "id": "C00002", "database": "COMPOUND", "url": "" }, { "id": "000004261765", "database": "ZINC", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A096UWG9", "gene_name": "Dgke", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "A0A096UWG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A096UWG9" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "A0A096UWG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A096UWG9" } ] } ] }, { "uniprot_ac": "A0A0B4KHZ4", "gene_name": "Dmel\\CG31140", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "A0A0B4KHZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0B4KHZ4" } ] }, { "ec_number": "2.7.1.23", "activity": "ATP + NAD(+) = ADP + H(+) + NADP(+).", "evidence": [ { "id": "A0A0B4KHZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0B4KHZ4" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "A0A0B4KHZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0B4KHZ4" } ] } ] }, { "uniprot_ac": "A8JQ65", "gene_name": "", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "A8JQ65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A8JQ65" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "A8JQ65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A8JQ65" } ] } ] }, { "uniprot_ac": "D3YWQ0", "gene_name": "Dgki", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "D3YWQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3YWQ0" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "D3YWQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3YWQ0" } ] } ] }, { "uniprot_ac": "D3YXJ0", "gene_name": "Dgkh", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "D3YXJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3YXJ0" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "D3YXJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3YXJ0" } ] } ] }, { "uniprot_ac": "D3Z9L0", "gene_name": "Agk", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "D3Z9L0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z9L0" } ] }, { "ec_number": "2.7.1.94", "activity": "a monoacylglycerol + ATP = ADP + H(+) + monoacyl-sn-glycero-3-phosphate.", "evidence": [ { "id": "D3Z9L0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z9L0" } ] }, { "ec_number": "2.7.1.138", "activity": "an N-acylsphing-4-enine + ATP = ADP + an N-acylsphing-4-enine 1-phosphate + H(+).", "evidence": [ { "id": "D3Z9L0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z9L0" } ] }, { "ec_number": "2.7.1.94", "activity": "", "evidence": [ { "id": "D3Z9L0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z9L0" } ] }, { "ec_number": "2.7.1.138", "activity": "", "evidence": [ { "id": "D3Z9L0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z9L0" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "D3Z9L0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z9L0" } ] } ] }, { "uniprot_ac": "D3ZEY4", "gene_name": "Dgkq", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "D3ZEY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZEY4" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "D3ZEY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZEY4" } ] } ] }, { "uniprot_ac": "D3ZSZ6", "gene_name": "Dgkh", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "D3ZSZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZSZ6" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "D3ZSZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZSZ6" } ] } ] }, { "uniprot_ac": "E9PUQ8", "gene_name": "Dgkd", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "E9PUQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PUQ8" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "E9PUQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PUQ8" } ] } ] }, { "uniprot_ac": "F1LZW2", "gene_name": "Dgkk", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "F1LZW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LZW2" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "F1LZW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LZW2" } ] } ] }, { "uniprot_ac": "F1M5T2", "gene_name": "Dgkd", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "F1M5T2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M5T2" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "F1M5T2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M5T2" } ] } ] }, { "uniprot_ac": "F1MAB7", "gene_name": "Dgki", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "F1MAB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1MAB7" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "F1MAB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1MAB7" } ] } ] }, { "uniprot_ac": "F6UUZ3", "gene_name": "Dgkk", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "F6UUZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F6UUZ3" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "F6UUZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F6UUZ3" } ] } ] }, { "uniprot_ac": "O08560", "gene_name": "Dgkz", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "O08560", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08560" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "O08560", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08560" } ] } ] }, { "uniprot_ac": "O75912", "gene_name": "DGKI", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "O75912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75912" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "O75912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75912" } ] } ] }, { "uniprot_ac": "O88673", "gene_name": "Dgka", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "O88673", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88673" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "O88673", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88673" } ] } ] }, { "uniprot_ac": "P23743", "gene_name": "DGKA", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "P23743", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23743" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "P23743", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23743" } ] } ] }, { "uniprot_ac": "P34125", "gene_name": "dgkA", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "P34125", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34125" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "P34125", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34125" } ] } ] }, { "uniprot_ac": "P49619", "gene_name": "DGKG", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "P49619", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49619" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "P49619", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49619" } ] } ] }, { "uniprot_ac": "P49620", "gene_name": "Dgkg", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "P49620", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49620" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "P49620", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49620" } ] } ] }, { "uniprot_ac": "P49621", "gene_name": "Dgkb", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "P49621", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49621" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "P49621", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49621" } ] } ] }, { "uniprot_ac": "P51556", "gene_name": "Dgka", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "P51556", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51556" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "P51556", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51556" } ] } ] }, { "uniprot_ac": "P52429", "gene_name": "DGKE", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "P52429", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52429" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "P52429", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52429" } ] } ] }, { "uniprot_ac": "P52824", "gene_name": "DGKQ", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "P52824", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52824" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "P52824", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52824" } ] } ] }, { "uniprot_ac": "Q01583", "gene_name": "Dgk", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "Q01583", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01583" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "Q01583", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01583" } ] } ] }, { "uniprot_ac": "Q09103", "gene_name": "rdgA", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "Q09103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q09103" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "Q09103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q09103" } ] } ] }, { "uniprot_ac": "Q13574", "gene_name": "DGKZ", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "Q13574", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13574" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "Q13574", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13574" } ] } ] }, { "uniprot_ac": "Q16760", "gene_name": "DGKD", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "Q16760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16760" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "Q16760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16760" } ] } ] }, { "uniprot_ac": "Q53H12", "gene_name": "AGK", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "Q53H12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q53H12" } ] }, { "ec_number": "2.7.1.94", "activity": "a monoacylglycerol + ATP = ADP + H(+) + monoacyl-sn-glycero-3-phosphate.", "evidence": [ { "id": "Q53H12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q53H12" } ] }, { "ec_number": "2.7.1.138", "activity": "an N-acylsphing-4-enine + ATP = ADP + an N-acylsphing-4-enine 1-phosphate + H(+).", "evidence": [ { "id": "Q53H12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q53H12" } ] }, { "ec_number": "2.7.1.94", "activity": "", "evidence": [ { "id": "Q53H12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q53H12" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "Q53H12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q53H12" } ] }, { "ec_number": "2.7.1.138", "activity": "", "evidence": [ { "id": "Q53H12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q53H12" } ] } ] }, { "uniprot_ac": "Q5KSL6", "gene_name": "DGKK", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "Q5KSL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5KSL6" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "Q5KSL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5KSL6" } ] } ] }, { "uniprot_ac": "Q6NS52", "gene_name": "Dgkb", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "Q6NS52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6NS52" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "Q6NS52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6NS52" } ] } ] }, { "uniprot_ac": "Q6P5E8", "gene_name": "Dgkq", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "Q6P5E8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P5E8" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "Q6P5E8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P5E8" } ] } ] }, { "uniprot_ac": "Q7K579", "gene_name": "Dgkepsilon", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "Q7K579", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7K579" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "Q7K579", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7K579" } ] } ] }, { "uniprot_ac": "Q80UP3", "gene_name": "Dgkz", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "Q80UP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80UP3" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "Q80UP3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80UP3" } ] } ] }, { "uniprot_ac": "Q86XP1", "gene_name": "DGKH", "activity": [ { "ec_number": "2.7.1.107", "activity": 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