{ "uniprot_canonical_ac": "Q9ESK9-1", "uniprot_ac": "Q9ESK9", "uniprot_id": "RBCC1_MOUSE", "mass": { "chemical_mass": 182350.0, "monoisotopic_mass": 182350.0 }, "refseq": { "ac": "NP_033956", "name": "RB1-inducible coiled-coil protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033956" }, "gene_names": [ { "name": "Rb1cc1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q9ESK9", "id": "Q9ESK9" }, { "name": "2900055E04Rik; 5930404L04Rik; Cc1; FIP200; LaXp180", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033956", "id": "NP_033956" }, { "name": "Cc1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9ESK9", "id": "Q9ESK9" }, { "name": "Kiaa0203", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9ESK9", "id": "Q9ESK9" }, { "name": "Rb1cc1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033956", "id": "NP_033956" } ], "protein_names": [ { "name": "RB1-inducible coiled-coil protein 1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q9ESK9" }, { "name": "200 kDa FAK family kinase-interacting protein; coiled-coil-forming protein 1; FAK family kinase-interacting protein of 200 kDa", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033956", "id": "NP_033956" }, { "name": "Coiled-coil-forming protein 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9ESK9" }, { "name": "FAK family kinase-interacting protein of 200 kDa", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9ESK9" }, { "name": "FIP200", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9ESK9" }, { "name": "LaXp180", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9ESK9" }, { "name": "RB1-inducible coiled-coil protein 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033956", "id": "NP_033956" } ], "function": [ { "annotation": "Autophagy in PDGFRalpha+ mesenchymal cells is essential for intestinal stem cell survival.", "evidence": [ { "database": "RefSeq", "id": "NP_033956", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033956" }, { "database": "PubMed", "id": "35537042", "url": "https://glygen.org/publication/PubMed/35537042" } ] }, { "annotation": "FIP200 restricts RNA virus infection by facilitating RIG-I activation. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_033956", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033956" }, { "database": "PubMed", "id": "34326461", "url": "https://glygen.org/publication/PubMed/34326461" } ] }, { "annotation": "Involved in autophagy (PubMed:23262492, PubMed:19258318). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225, PubMed:23285000, PubMed:19258318). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (PubMed:21525242). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (PubMed:21807966). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (By similarity). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (PubMed:21795712). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:15968549). Plays a crucial role in muscular differentiation (PubMed:15968549). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (PubMed:19940130, PubMed:21088496).", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9#function" }, { "database": "UniProtKB", "id": "Q8TDY2", "url": "https://www.uniprot.org/uniprot/Q8TDY2#function" }, { "database": "PubMed", "id": "15968549", "url": "https://glygen.org/publication/PubMed/15968549" }, { "database": "PubMed", "id": "21088496", "url": "https://glygen.org/publication/PubMed/21088496" }, { "database": "PubMed", "id": "23262492", "url": "https://glygen.org/publication/PubMed/23262492" }, { "database": "PubMed", "id": "23392225", "url": "https://glygen.org/publication/PubMed/23392225" }, { "database": "PubMed", "id": "23285000", "url": "https://glygen.org/publication/PubMed/23285000" }, { "database": "PubMed", "id": "21795712", "url": "https://glygen.org/publication/PubMed/21795712" }, { "database": "PubMed", "id": "19258318", "url": "https://glygen.org/publication/PubMed/19258318" }, { "database": "PubMed", "id": "21807966", "url": "https://glygen.org/publication/PubMed/21807966" }, { "database": "PubMed", "id": "21525242", "url": "https://glygen.org/publication/PubMed/21525242" }, { "database": "PubMed", "id": "19940130", "url": "https://glygen.org/publication/PubMed/19940130" }, { "database": "PubMed", "id": "12095676", "url": "https://glygen.org/publication/PubMed/12095676" } ] }, { "annotation": "Non-canonical function of FIP200 is required for neural stem cell maintenance and differentiation by limiting TBK1 activation and p62 aggregate formation. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_033956", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033956" }, { "database": "PubMed", "id": "34903812", "url": "https://glygen.org/publication/PubMed/34903812" } ] } ], "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ], "evidence": [ { "id": "1612", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1612" } ] } ], "snv": [ { "evidence": [ { "id": "rs3388457069", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs3388457069" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 435, "end_pos": 435, "sequence_org": "K", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (KCT->NCT).", "chr_id": "1", "chr_pos": "6315153", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "K435", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Rb1cc1", "url": "https://www.uniprot.org/uniprot/Q9ESK9", "locus": { "chromosome": "1", "start_pos": 6346872, "end_pos": 6276421, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000025907", "url": "https://www.ensembl.org/id/ENSMUSG00000025907" } ] } } ], "crossref": [ { "id": "ENSMUSG00000025907", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000025907", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd17060", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd17060", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "12421", "url": "https://www.ncbi.nlm.nih.gov/gene/12421", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q9ESK9", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q9ESK9*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR019460", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019460", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR029071", "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR040040", "url": "https://www.ebi.ac.uk/interpro/entry/IPR040040", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045326", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045326", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:12421", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:12421", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1341850", "url": "http://www.informatics.jax.org/marker/MGI:1341850", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "Q9ESK9", "url": "https://oglcnac.org/atlas/detail/Q9ESK9", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "Q9ESK9", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9ESK9", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "EKMALCE", "url": "https://omabrowser.org/oma/group/EKMALCE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2878794at2759", "url": "http://www.orthodb.org/?query=2878794at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13222", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13222", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13222:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13222:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF04108", "url": "http://pfam.xfam.org/family/PF04108", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF10377", "url": "http://pfam.xfam.org/family/PF10377", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q9ESK9", "url": "http://purl.obolibrary.org/obo/PR_Q9ESK9", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-1632852", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1632852", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_033956", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033956", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E0CYU7", "url": "https://www.uniprot.org/uniprot/E0CYU7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E0CYU7-1", "url": "https://www.uniprot.org/uniprot/E0CYU7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E0CYY6", "url": "https://www.uniprot.org/uniprot/E0CYY6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E0CYY6-1", "url": "https://www.uniprot.org/uniprot/E0CYY6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E0CZG6", "url": "https://www.uniprot.org/uniprot/E0CZG6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E0CZG6-1", "url": "https://www.uniprot.org/uniprot/E0CZG6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9PX56", "url": "https://www.uniprot.org/uniprot/E9PX56", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9PX56-1", "url": "https://www.uniprot.org/uniprot/E9PX56-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6TLJ4", "url": "https://www.uniprot.org/uniprot/F6TLJ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6TLJ4-1", "url": "https://www.uniprot.org/uniprot/F6TLJ4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F7CC56", "url": "https://www.uniprot.org/uniprot/F7CC56", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F7CC56-1", "url": "https://www.uniprot.org/uniprot/F7CC56-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F7CCJ3", "url": "https://www.uniprot.org/uniprot/F7CCJ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F7CCJ3-1", "url": "https://www.uniprot.org/uniprot/F7CCJ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9ESK9-1", "url": "https://www.uniprot.org/uniprot/Q9ESK9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKLYVFLVNTGTTLTFDTELTVQTVADLKHAIQSKYKIAIQHQVLVVNGGECMAADRRVCTYSAGTDTNPIFLFNKEMILCDRAPAIPKATFSTENDMEIKVEESLMMPAVFHTVASRTQLAVEMYDVAKKLCSFCEGLVHDEHLQHQGWAAIMANLEDCSNSYQKLLFKFESIYSDYLQSIEDIKLKLTHLGTAVSVMAKIPLLECLTRHSYRECLGRPDSLNEHEGSEKAEMKRSTELVLSPDMPRTTNTSLVTSFHKSMEHVAPDPTGTERGKELRESCQSTVQQEEASVDAKDSDLPFFNVSLLDWINVQDRPNDVESLVRKCFDSMSRLDPKIIQPFMLECHQTIAKLDNQNMKAIKGLEDRLYALDQMIASCSRLVNEQKELAQGFLANQMRAENLKDASVLPDLCLSHANQLMIMLQNHRKLLDIKQKCTTAKQELANNLHVRLKWCCFVMLHADQDGEKLQALLRLVIELLERVRIVEALSTVPQMYCLAVVEVVRRKMFIKHYREWAGALVKDGKQLYEAEKSKRESFGKLFRKSFLRNRLFKGLDSWPSSFCTQKPRKFDCELPDISLKDLQFLQSFCPSEVQPFLRVPLLCDFEPLHQHVLALHNLVKAAQSLDEMSQTITDLLNEQKVSTSQASPQSAASPRIESTTGITTTTSPKTPPPLTVQDTLCPAVCPLEELSPDSIDAHTFDFETISHPNTEQPVHQASIDLDSLAESPESDFMSAVNEFVIEENLSSPNPISDPQSPEMMVESLYSSVINAIDSRRMQDTSTRGNEGFGDRAALHVQLEKCRAAAQDSHSSIQTIKDDLCHFRTFVQKEQCDLANYLKCTAVEIRNIIEKVKCSLEITLKEKHQQELQSLKIEYECKLDALVKDSEENVNKILKLKENLVSLEEALQNKDNEFTSIKHEKDAIVCVQQEKDQKLLEMEKIMHTQHCEIKELKQSREMALEDLKKLHDEKIESLRAEFQCLEQNHLKELEDTLHIRHTQEFEKVMTDHNMSLEKLKKENQQRIDQMLESHASTIQEKEQQLQELKLKVSDLSDMRCKLEVELALKEAETDEIKILLEESRTQQKEMLKSLLEQETENLRTEISKLNQKIHDNNESYQVGLSELRALMTIEKDQCISELISRHEEESNILKAELDNVTSLHRQAYEIEKKLKEQIVELQTRLNSELSALEKQKDEKITQQEEKYEALIQNLEKDKERLVKNHEQDKEHLIQELNFEKNKAVQTALDEFKVERELVEKELLEKVKHLENQIAKTPAFESAREDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKQLEEEVSKLRTSSFLSSAPVAAAPELYGACAPELPGEPERSVMETADEGRLDSAMETSMMSVQENMLSEEKQRIMLLERTLQLKEEENKRLNQRLMSQSLSSVSSRHSEKIAIRDFQVGDLVLIILDERHDNYVLFTVSPTLYFLHSESLPALDLKPGEGASGASRRPWVLGKVMEKEYCQAKKAQNRFKVPLGTKFYRVKAVSWNKKV", "length": 1588, "header": "sp|Q9ESK9-1|RBCC1_MOUSE Isoform 1 of RB1-inducible coiled-coil protein 1 OS=Mus musculus OX=10090 GN=Rb1cc1 PE=1 SV=3 CANONICAL=Q9ESK9-1" }, "isoforms": [ { "isoform_ac": "E0CYU7-1", "url": "", "sequence": { "sequence": "MKLYVFLVNTGTTLTFDTELTVQTVADLKHAIQSKYKIAI", "length": 40, "header": "tr|E0CYU7-1|E0CYU7_MOUSE Computationally mapped isoform of RB1-inducible coiled-coil 1 OS=Mus musculus OX=10090 GN=Rb1cc1 PE=4 SV=1 CANONICAL=Q9ESK9-1" }, "locus": { "chromosome": "1", "start_pos": 6304233, "end_pos": 6300227, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000160062.8", "url": "https://www.ensembl.org/id/ENSMUST00000160062.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000123876.2", "url": "https://www.ensembl.org/id/ENSMUSP00000123876.2" } ] } }, { "isoform_ac": "E0CYY6-1", "url": "", "sequence": { "sequence": "MKLYVFLVNTGTTLTFDTELTVQTVADLKHAIQSKYKIAIQHQVLVVNGGECMAADRRVCTYSAGTDTNPIFLFNKEMILCDRAPAIPKATFSTENDMEIKVEESLMMPAVFHTVASRTQLAVEMYDVAKKLCSFCEGLVHDEHLQHQGWAAIMANLEDCSNSY", "length": 164, "header": "tr|E0CYY6-1|E0CYY6_MOUSE Computationally mapped isoform of RB1-inducible coiled-coil 1 OS=Mus musculus OX=10090 GN=Rb1cc1 PE=1 SV=1 CANONICAL=Q9ESK9-1" }, "locus": { "chromosome": "1", "start_pos": 6308608, "end_pos": 6300227, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000160871.8", "url": "https://www.ensembl.org/id/ENSMUST00000160871.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000123768.2", "url": "https://www.ensembl.org/id/ENSMUSP00000123768.2" } ] } }, { "isoform_ac": "E0CZG6-1", "url": "", "sequence": { "sequence": "MKLYVFLVNTGTTLTFDTELTVQTVADLKHAIQSKYKIAIQHQVLVVNGGECMAADRRVCTYSAGTDTNPIFLFNKEMILCDRAPAIPKATFS", "length": 93, "header": "tr|E0CZG6-1|E0CZG6_MOUSE Computationally mapped isoform of RB1-inducible coiled-coil 1 OS=Mus musculus OX=10090 GN=Rb1cc1 PE=1 SV=8 CANONICAL=Q9ESK9-1" }, "locus": { "chromosome": "1", "start_pos": 6304533, "end_pos": 6300227, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000159906.8", "url": "https://www.ensembl.org/id/ENSMUST00000159906.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000125396.2", "url": "https://www.ensembl.org/id/ENSMUSP00000125396.2" } ] } }, { "isoform_ac": "E9PX56-1", "url": "", "sequence": { "sequence": "MKLYVFLVNTGTTLTFDTELTVQTVADLKHAIQSKYKIAIQHQVLVVNGGECMAADRRVCTYSAGTDTNPIFLFNKEMILCDRAPAIPKATFSTENDMEIKVEESLMMPAVFHTVASRTQLAVEMYDVAKKLCSFCEGLVHDEHLQHQGWAAIMANLEDCSNSYQKLLFKFESIYSDYLQSIEDIKLKLTHLGTAVSVMAKIPLLECLTRHSYRECLGRPDSLNEHEGSEKAEMKRSTELVLSPDMPRTTNTSLVTSFHKSMEHVAPDPTGTERGKELRESCQSTVQQEEASVDAKDSDLPFFNVSLLDWINVQDRPNDVESLVRKCFDSMSRLDPKIIQPFMLECHQTIAKLDNQNMKAIKGLEDRLYALDQMIASCSRLVNEQKELAQGFLANQMRAENLKDASVLPDLCLSHANQLMIMLQNHRKLLDIKQKWCCFVMLHADQDGEKLQALLRLVIELLERVRIVEALSTVPQMYCLAVVEVVRRKMFIKHYREWAGALVKDGKQLYEAEKSKRESFGKLFRKSFLRNRLFKGLDSWPSSFCTQKPRKFDCELPDISLKDLQFLQSFCPSEVQPFLRVPLLCDFEPLHQHVLALHNLVKAAQSLDEMSQTITDLLNEQKVSTSQASPQSAASPRIESTTGITTTTSPKTPPPLTVQDTLCPAVCPLEELSPDSIDAHTFDFETISHPNTEQPVHQASIDLDSLAESPESDFMSAVNEFVIEENLSSPNPISDPQSPEMMVESLYSSVINAIDSRRMQDTSTRGNEGFGDRAALHVQLEKCRAAAQDSHSSIQTIKDDLCHFRTFVQKEQCDLANYLKCTAVEIRNIIEKVKCSLEITLKEKHQQELQSLKIEYECKLDALVKDSEENVNK", "length": 873, "header": "tr|E9PX56-1|E9PX56_MOUSE Computationally mapped isoform of RB1-inducible coiled-coil 1 OS=Mus musculus OX=10090 GN=Rb1cc1 PE=1 SV=1 CANONICAL=Q9ESK9-1" }, "locus": { "chromosome": "1", "start_pos": 6319252, "end_pos": 6300227, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000162795.8", "url": "https://www.ensembl.org/id/ENSMUST00000162795.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000124676.2", "url": "https://www.ensembl.org/id/ENSMUSP00000124676.2" } ] } }, { "isoform_ac": "F6TLJ4-1", "url": "", "sequence": { "sequence": "RDKDLIESLSEDRARLLEEKKQLEEEVSKLRTSSFLSSAPVAAAPELYGACAPELPGEPERSVMETADEGRLDSAMETSMMSVQENMLSEEKQRIMLLERTLQLKEEENKRLNQRLMSQSLSSVSSRHSEKIAIRDFQVGDLVLIILDERHDNYVLFTVSPTLYFLHSESLPALDLKPASGASRRPWVLGKVMEKEYCQAKKAQNRFKVPLGTKFYRVKAVSWNKKV", "length": 227, "header": "tr|F6TLJ4-1|F6TLJ4_MOUSE Computationally mapped isoform of RB1-inducible coiled-coil 1 OS=Mus musculus OX=10090 GN=Rb1cc1 PE=1 SV=1 CANONICAL=Q9ESK9-1" }, "locus": { "chromosome": "1", "start_pos": 6344496, "end_pos": 6333157, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000159530.2", "url": "https://www.ensembl.org/id/ENSMUST00000159530.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000124220.2", "url": "https://www.ensembl.org/id/ENSMUSP00000124220.2" } ] } }, { "isoform_ac": "F7CC56-1", "url": "", "sequence": { "sequence": "XAPAIPKATFSTENDMEIKVEESLMMPAVFHTVASRTQLAVEMYDVAKKLCSFCEGLVHDEHLQHQGWAAIMANLEDCSNSYQKLLFKFESIYSDYLQSIEDIKLKLTHLGTAVSVMAKIPLLECLTRHSYRECLGRPDSLNEHEGSEKAEMKRSTELVLSPDMPRTTNTSLVTSFHKSMEHVAPDPTDWINVQDRPNDVESLVRKCFDSMSRLDPKIIQPFMLECHQTIAKLDNQNMKAIKGLEDRLYALDQMIASCSRLVNEQKELAQGFLANQMRAENLKDASVLPDLCLSHANQLMIMLQNHRKLLDIKQKCTTAKQELANNLHVRLKWCCFVMLHADQDGEKLQALLRLVIELLERVRIVEALSTVPQMYCLAVVEVVRRKMFIKHYREWAGALVKDGKQLYEAEKSKRESFGKLFRKSFLRNRLFKGLDSWPSSFCTQKPRKFDCELPDISLKDLQFLQSFCPSEVQPFLRVPLLCDFEPLHQHVLALHNLVKAAQSLDEMSQTITDLLNEQKVSTSQASPQSAASPRIESTTGITTTTSPKTPPPLTVQDTLCPAVCPLEELSPDSIDAHTFDFETISHPNTEQPVHQASIDLDSLAESPESDFMSAVNEFVIEENLSSPNPISDPQSPEMMVESLYSSVINAIDSRRMQDTSTRGNEGFGDRAALHVQLEKCRAAAQDSHSSIQTIKDDLCHFRTFVQKEQCDLANYLKCTAVEIRNIIEKVKCSLEITLKEKHQQELQSLKIEYECKLDALVKDSEENVNKILKLKENLVSLEEALQNKDNEFTSIKHEKDAIVCVQQEKDQKLLEMEKIMHTQHCEIKELKQSREMALEDLKKLHDEKIESLRAEFQCLEQNHLKELEDTLHIRHTQEFEKVMTDHNMSLEKLKKENQQRIDQMLESHASTIQEKEQQLQELKLKVSDLSDMRCKLEVELALKEAETDEIKILLEESRTQQKEMLKSLLEQETENLRTEISKLNQKIHDNNESYQVGLSELRALMTIEKDQCISELISRHEEESNILKAELDNVTSLHRQAYEIEKKLKEQIVELQTRLNSELSALEKQKDEKITQQEEKYEALIQNLEKDKERLVKNHEQDKEHLIQELNFEKNKAVQTALDEFKVERELVEKELLEKVKHLENQIAKTPAFESAREDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKQLEEEVSKLRTSSFLSSAPVAAAPELYGACAPELPGEPERSVMETADEGRLDSAMETSMMSVQENMLSEEKQRIMLLERTLQLKEEENKRLNQRLMSQSLSSVSSRHSEKIAIRDFQVGDLVLIILDERHDNYVLFTVSPTLYFLHSESLPALDLKPGEGASGASRRPWVLGKVMEKEYCQAKKAQNRFKVPLGTKFYRVKAVSWNKKV", "length": 1468, "header": "tr|F7CC56-1|F7CC56_MOUSE Computationally mapped isoform of RB1-inducible coiled-coil 1 OS=Mus musculus OX=10090 GN=Rb1cc1 PE=1 SV=1 CANONICAL=Q9ESK9-1" }, "locus": { "chromosome": "1", "start_pos": 6344498, "end_pos": 6304503, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000161327.8", "url": "https://www.ensembl.org/id/ENSMUST00000161327.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000125348.2", "url": "https://www.ensembl.org/id/ENSMUSP00000125348.2" } ] } }, { "isoform_ac": "F7CCJ3-1", "url": "", "sequence": { "sequence": "XEFTSIKHEKDAIVCVQQEKDQKLLEMEKIMHTQHCEIKELKQSREMALEDLKKLHDEKIESLRAEFQCLEQNHLKELEDTLHIRHTQEFEKVMTDHNMSLEKLKKENQQRIDQMLESHASTIQEKEQQLQELKLKVSDLSDMRCKLEVELALKEAETDEIKILLEESRTQQKEMLKSLLEQETENLRTEISKLNQKIHDNNESYQVGLSELRALMTIEKDQCISELISRHEEESNILKAELDNVTSLHRQAYEIEKKLKEQIVELQTRLNSELSALEKQKDEKITQQEEKYEALIQNLEKDKERLVKNHEQDKEHLIQELNFEKNKAVQTALDEFKVERELVEKELLEKVKHLENQIAKTPAFESAREDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKQLEEEVSKLRTSSFLSSAPVAAAPELYGACAPELPGEPERSVMETADEGRLDSAMETSMMSVQHCS", "length": 536, "header": "tr|F7CCJ3-1|F7CCJ3_MOUSE Computationally mapped isoform of RB1-inducible coiled-coil 1 OS=Mus musculus OX=10090 GN=Rb1cc1 PE=1 SV=1 CANONICAL=Q9ESK9-1" }, "locus": { "chromosome": "1", "start_pos": 6335809, "end_pos": 6319312, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000162257.8", "url": "https://www.ensembl.org/id/ENSMUST00000162257.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000125334.2", "url": "https://www.ensembl.org/id/ENSMUSP00000125334.2" } ] } }, { "isoform_ac": "Q9ESK9-1", "url": "", "sequence": { "sequence": "MKLYVFLVNTGTTLTFDTELTVQTVADLKHAIQSKYKIAIQHQVLVVNGGECMAADRRVCTYSAGTDTNPIFLFNKEMILCDRAPAIPKATFSTENDMEIKVEESLMMPAVFHTVASRTQLAVEMYDVAKKLCSFCEGLVHDEHLQHQGWAAIMANLEDCSNSYQKLLFKFESIYSDYLQSIEDIKLKLTHLGTAVSVMAKIPLLECLTRHSYRECLGRPDSLNEHEGSEKAEMKRSTELVLSPDMPRTTNTSLVTSFHKSMEHVAPDPTGTERGKELRESCQSTVQQEEASVDAKDSDLPFFNVSLLDWINVQDRPNDVESLVRKCFDSMSRLDPKIIQPFMLECHQTIAKLDNQNMKAIKGLEDRLYALDQMIASCSRLVNEQKELAQGFLANQMRAENLKDASVLPDLCLSHANQLMIMLQNHRKLLDIKQKCTTAKQELANNLHVRLKWCCFVMLHADQDGEKLQALLRLVIELLERVRIVEALSTVPQMYCLAVVEVVRRKMFIKHYREWAGALVKDGKQLYEAEKSKRESFGKLFRKSFLRNRLFKGLDSWPSSFCTQKPRKFDCELPDISLKDLQFLQSFCPSEVQPFLRVPLLCDFEPLHQHVLALHNLVKAAQSLDEMSQTITDLLNEQKVSTSQASPQSAASPRIESTTGITTTTSPKTPPPLTVQDTLCPAVCPLEELSPDSIDAHTFDFETISHPNTEQPVHQASIDLDSLAESPESDFMSAVNEFVIEENLSSPNPISDPQSPEMMVESLYSSVINAIDSRRMQDTSTRGNEGFGDRAALHVQLEKCRAAAQDSHSSIQTIKDDLCHFRTFVQKEQCDLANYLKCTAVEIRNIIEKVKCSLEITLKEKHQQELQSLKIEYECKLDALVKDSEENVNKILKLKENLVSLEEALQNKDNEFTSIKHEKDAIVCVQQEKDQKLLEMEKIMHTQHCEIKELKQSREMALEDLKKLHDEKIESLRAEFQCLEQNHLKELEDTLHIRHTQEFEKVMTDHNMSLEKLKKENQQRIDQMLESHASTIQEKEQQLQELKLKVSDLSDMRCKLEVELALKEAETDEIKILLEESRTQQKEMLKSLLEQETENLRTEISKLNQKIHDNNESYQVGLSELRALMTIEKDQCISELISRHEEESNILKAELDNVTSLHRQAYEIEKKLKEQIVELQTRLNSELSALEKQKDEKITQQEEKYEALIQNLEKDKERLVKNHEQDKEHLIQELNFEKNKAVQTALDEFKVERELVEKELLEKVKHLENQIAKTPAFESAREDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKQLEEEVSKLRTSSFLSSAPVAAAPELYGACAPELPGEPERSVMETADEGRLDSAMETSMMSVQENMLSEEKQRIMLLERTLQLKEEENKRLNQRLMSQSLSSVSSRHSEKIAIRDFQVGDLVLIILDERHDNYVLFTVSPTLYFLHSESLPALDLKPGEGASGASRRPWVLGKVMEKEYCQAKKAQNRFKVPLGTKFYRVKAVSWNKKV", "length": 1588, "header": "sp|Q9ESK9-1|RBCC1_MOUSE Isoform 1 of RB1-inducible coiled-coil protein 1 OS=Mus musculus OX=10090 GN=Rb1cc1 PE=1 SV=3 CANONICAL=Q9ESK9-1" }, "locus": { "chromosome": "1", "start_pos": 6344496, "end_pos": 6300227, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000027040", "url": "https://www.ensembl.org/id/ENSMUST00000027040" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000027040", "url": "https://www.ensembl.org/id/ENSMUSP00000027040" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 349, "start_aa": "Thr", "end_pos": 349, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr349", "evidence": [ { "id": "Q9ESK9", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9ESK9" }, { "id": "22645316", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22645316" }, { "id": "34418053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34418053" }, { "id": "36852467", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/36852467" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 641, "start_aa": "Ser", "end_pos": 641, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser641", "evidence": [ { "id": "Q9ESK9", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q9ESK9" }, { "id": "32782141", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32782141" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 643, "start_aa": "Ser", "end_pos": 643, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser643", "evidence": [ { "id": "Q9ESK9", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9ESK9" }, { "id": "22645316", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22645316" }, { "id": "34418053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34418053" }, { "id": "36852467", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/36852467" }, { "id": "Q9ESK9", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/Q9ESK9" }, { "id": "32782141", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32782141" } ] } ], "phosphorylation": [ { "start_pos": 1087, "end_pos": 1087, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q9ESK9", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9ESK9" } ], "site_lbl": "Ser1087" }, { "start_pos": 1366, "end_pos": 1366, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "site_lbl": "Ser1366" }, { "start_pos": 1478, "end_pos": 1478, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "site_lbl": "Ser1478" }, { "start_pos": 222, "end_pos": 222, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "site_lbl": "Ser222" }, { "start_pos": 229, "end_pos": 229, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "site_lbl": "Ser229" }, { "start_pos": 237, "end_pos": 237, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "phospho.ELM", "id": "Q9ESK9", "url": "http://phospho.elm.eu.org/byAccession/Q9ESK9.html" }, { "database": "iPTMnet", "id": "Q9ESK9", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9ESK9" }, { "database": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" } ], "site_lbl": "Ser237" }, { "start_pos": 238, "end_pos": 238, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q9ESK9", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9ESK9" } ], "site_lbl": "Thr238" }, { "start_pos": 243, "end_pos": 243, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q9ESK9", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9ESK9" } ], "site_lbl": "Ser243" }, { "start_pos": 253, "end_pos": 253, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "site_lbl": "Ser253" }, { "start_pos": 257, "end_pos": 257, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "site_lbl": "Ser257" }, { "start_pos": 261, "end_pos": 261, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q9ESK9", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9ESK9" } ], "site_lbl": "Ser261" }, { "start_pos": 623, "end_pos": 623, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q9ESK9", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9ESK9" } ], "site_lbl": "Ser623" }, { "start_pos": 646, "end_pos": 646, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q9ESK9", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9ESK9" } ], "site_lbl": "Ser646" }, { "start_pos": 649, "end_pos": 649, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q9ESK9", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9ESK9" } ], "site_lbl": "Ser649" }, { "start_pos": 652, "end_pos": 652, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q9ESK9", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9ESK9" } ], "site_lbl": "Ser652" }, { "start_pos": 665, "end_pos": 665, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "Q9ESK9", "url": "http://phospho.elm.eu.org/byAccession/Q9ESK9.html" }, { "database": "iPTMnet", "id": "Q9ESK9", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9ESK9" }, { "database": "PubMed", "id": "17114649", "url": "https://glygen.org/publication/PubMed/17114649" } ], "site_lbl": "Thr665" }, { "start_pos": 733, "end_pos": 733, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "site_lbl": "Ser733" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "LaXp180, a mammalian ActA-binding protein, identified with the yeast two-hybrid system co-localizes with intracellular Listeria monocytogenes.", "journal": "Cell. Microbiol.", "date": "2000", "authors": "Pfeuffer T, Goebel W, Laubinger J, Bachmann M, Kuhn M", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "reference": [ { "type": "PubMed", "id": "11207567", "url": "https://glygen.org/publication/PubMed/11207567" } ] }, { "title": "Isolation, characterization and mapping of the mouse and human RB1CC1 genes.", "journal": "Gene", "date": "2002", "authors": "Chano T, Ikegawa S, Saito-Ohara F, Inazawa J, Mabuchi A, Saeki Y, Okabe H", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "reference": [ { "type": "PubMed", "id": "12095676", "url": "https://glygen.org/publication/PubMed/12095676" } ] }, { "title": "Expression and regulation of RB1CC1 in developing murine and human tissues.", "journal": "Int. J. Mol. Med.", "date": "2004", "authors": "Takeuchi Y., Ohta S., Okabe H., Chano T., Taga T., Bamba N.", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "reference": [ { "type": "PubMed", "id": "15375585", "url": "https://glygen.org/publication/PubMed/15375585" } ] }, { "title": "Rb1cc1 is critical for myoblast differentiation through Rb1 regulation.", "journal": "Virchows Arch.", "date": "2005", "authors": "Inoue H., Okabe H., Watanabe R., Koiwai O., Chano T., Isono T.", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "reference": [ { "type": "PubMed", "id": "15968549", "url": "https://glygen.org/publication/PubMed/15968549" } ] }, { "title": "Comprehensive identification of phosphorylation sites in postsynaptic density preparations.", "journal": "Mol. Cell. Proteomics", "date": "2006", "authors": "Trinidad JC, Specht CG, Thalhammer A, Schoepfer R, Burlingame AL", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" }, { "database": "UniProtKB", "id": "F6TLJ4", "url": "https://www.uniprot.org/uniprot/F6TLJ4" }, { "database": "UniProtKB", "id": "F7CCJ3", "url": "https://www.uniprot.org/uniprot/F7CCJ3" }, { "database": "UniProtKB", "id": "F7CC56", "url": "https://www.uniprot.org/uniprot/F7CC56" } ], "reference": [ { "type": "PubMed", "id": "16452087", "url": "https://glygen.org/publication/PubMed/16452087" } ] }, { "title": "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.", "journal": "Molecular & cellular proteomics : MCP", "date": "2007", "authors": "Munton RP, Tweedie-Cullen R, Livingstone-Zatchej M, Weinandy F, Waidelich M, Longo D, Gehrig P, Potthast F, Rutishauser D, Gerrits B, Panse C, Schlapbach R, Mansuy IM", "evidence": [ { "database": "iPTMnet", "id": "Q9ESK9", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9ESK9" } ], "reference": [ { "type": "PubMed", "id": "17114649", "url": "https://glygen.org/publication/PubMed/17114649" } ] }, { "title": "Large-scale phosphorylation analysis of mouse liver.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2007", "authors": "Villen J, Beausoleil SA, Gerber SA, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" }, { "database": "UniProtKB", "id": "E9PX56", "url": "https://www.uniprot.org/uniprot/E9PX56" }, { "database": "UniProtKB", "id": "F7CC56", "url": "https://www.uniprot.org/uniprot/F7CC56" }, { "database": "iPTMnet", "id": "Q9ESK9", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9ESK9" } ], "reference": [ { "type": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" } ] }, { "title": "ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy.", "journal": "J. Biol. Chem.", "date": "2009", "authors": "Ganley IG, Lam du H, Wang J, Ding X, Chen S, Jiang X", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "reference": [ { "type": "PubMed", "id": "19258318", "url": "https://glygen.org/publication/PubMed/19258318" } ] }, { "title": "Neural-specific deletion of FIP200 leads to cerebellar degeneration caused by increased neuronal death and axon degeneration.", "journal": "J. Biol. Chem.", "date": "2010", "authors": "Wang C., Peng X., Guan J.L., Liang C.C., Gan B.", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "reference": [ { "type": "PubMed", "id": "19940130", "url": "https://glygen.org/publication/PubMed/19940130" } ] }, { "title": "FIP200, an essential component of mammalian autophagy is indispensible for fetal hematopoiesis.", "journal": "Autophagy", "date": "2011", "authors": "Liu F., Guan J.L.", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "reference": [ { "type": "PubMed", "id": "21088496", "url": "https://glygen.org/publication/PubMed/21088496" } ] }, { "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.", "journal": "Cell", "date": "2010", "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" }, { "database": "iPTMnet", "id": "Q9ESK9", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9ESK9" } ], "reference": [ { "type": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] }, { "title": "The LC3 recruitment mechanism is separate from Atg9L1-dependent membrane formation in the autophagic response against Salmonella.", "journal": "Mol. Biol. Cell", "date": "2011", "authors": "Kageyama S, Omori H, Saitoh T, Sone T, Guan JL, Akira S, Imamoto F, Noda T, Yoshimori T", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "reference": [ { "type": "PubMed", "id": "21525242", "url": "https://glygen.org/publication/PubMed/21525242" } ] }, { "title": "RB1CC1 protein positively regulates transforming growth factor-beta signaling through the modulation of Arkadia E3 ubiquitin ligase activity.", "journal": "J. Biol. Chem.", "date": "2011", "authors": "Nagano Y., Goto K., Imamura T., Miyazono K., Saitoh M., Chano T., Ikushima H., Miyazawa K., Koinuma D., Shinozaki M., Horiguchi K.", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "reference": [ { "type": "PubMed", "id": "21795712", "url": "https://glygen.org/publication/PubMed/21795712" } ] }, { "title": "Suppression of autophagy by FIP200 deletion impairs DNA damage repair and increases cell death upon treatments with anticancer agents.", "journal": "Mol. Cancer Res.", "date": "2011", "authors": "Guan J.L., Bae H.", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "reference": [ { "type": "PubMed", "id": "21807966", "url": "https://glygen.org/publication/PubMed/21807966" } ] }, { "title": "Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse.", "journal": "Molecular & cellular proteomics : MCP", "date": "2012", "authors": "Trinidad JC, Barkan DT, Gulledge BF, Thalhammer A, Sali A, Schoepfer R, Burlingame AL", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9ESK9", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9ESK9" } ], "reference": [ { "type": "PubMed", "id": "22645316", "url": "https://glygen.org/publication/PubMed/22645316" } ] }, { "title": "Interaction between FIP200 and ATG16L1 distinguishes ULK1 complex-dependent and -independent autophagy.", "journal": "Nat. Struct. Mol. Biol.", "date": "2013", "authors": "Jiang X., Florey O., Gammoh N., Overholtzer M.", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "reference": [ { "type": "PubMed", "id": "23262492", "url": "https://glygen.org/publication/PubMed/23262492" } ] }, { "title": "Autophagy induced by calcium phosphate precipitates involves endoplasmic reticulum membranes in autophagosome biogenesis.", "journal": "PLoS ONE", "date": "2012", "authors": "Chen X., Li M., Chen D., Komatsu M., Yin X.M., Gao W., Guan J.L.", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "reference": [ { "type": "PubMed", "id": "23285000", "url": "https://glygen.org/publication/PubMed/23285000" } ] }, { "title": "FIP200 regulates targeting of Atg16L1 to the isolation membrane.", "journal": "EMBO Rep.", "date": "2013", "authors": "Nishimura T, Kaizuka T, Cadwell K, Sahani MH, Saitoh T, Akira S, Virgin HW, Mizushima N", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "reference": [ { "type": "PubMed", "id": "23392225", "url": "https://glygen.org/publication/PubMed/23392225" } ] }, { "title": "WIPI3 and WIPI4 beta-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy.", "journal": "Nat. Commun.", "date": "2017", "authors": "Bakula D, Muller AJ, Zuleger T, Takacs Z, Franz-Wachtel M, Thost AK, Brigger D, Tschan MP, Frickey T, Robenek H, Macek B, Proikas-Cezanne T", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "reference": [ { "type": "PubMed", "id": "28561066", "url": "https://glygen.org/publication/PubMed/28561066" } ] }, { "title": "Cytosolic N-GlcNAc proteins are formed by the action of endo-beta-N-acetylglucosaminidase.", "journal": "Biochemical and biophysical research communications", "date": "2020", "authors": "Maynard JC, Fujihira H, Dolgonos GE, Suzuki T, Burlingame AL", "evidence": [ { "database": "O-GlcNAc Atlas", "id": "Q9ESK9", "url": "https://oglcnac.org/atlas/detail/Q9ESK9" } ], "reference": [ { "type": "PubMed", "id": "32782141", "url": "https://glygen.org/publication/PubMed/32782141" } ] }, { "title": "FIP200 restricts RNA virus infection by facilitating RIG-I activation.", "journal": "Communications biology", "date": "2021", "authors": "Wang L, Song K, Hao W, Wu Y, Patil G, Hua F, Sun Y, Huang C, Ritchey J, Jones C, Liu L, Guan JL, Li S", "evidence": [ { "database": "RefSeq", "id": "NP_033956", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033956" } ], "reference": [ { "type": "PubMed", "id": "34326461", "url": "https://glygen.org/publication/PubMed/34326461" } ] }, { "title": "O-GlcNAcylation Is Essential for Rapid Pomc Expression and Cell Proliferation in Corticotropic Tumor Cells.", "journal": "Endocrinology", "date": "2021", "authors": "Massman LJ, Pereckas M, Zwagerman NT, Olivier-Van Stichelen S", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9ESK9", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9ESK9" } ], "reference": [ { "type": "PubMed", "id": "34418053", "url": "https://glygen.org/publication/PubMed/34418053" } ] }, { "title": "Non-canonical function of FIP200 is required for neural stem cell maintenance and differentiation by limiting TBK1 activation and p62 aggregate formation.", "journal": "Scientific reports", "date": "2021", "authors": "Liu H, Wang C, Yi F, Yeo S, Haas M, Tang X, Guan JL", "evidence": [ { "database": "RefSeq", "id": "NP_033956", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033956" } ], "reference": [ { "type": "PubMed", "id": "34903812", "url": "https://glygen.org/publication/PubMed/34903812" } ] }, { "title": "Autophagy in PDGFRalpha+ mesenchymal cells is essential for intestinal stem cell survival.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2022", "authors": "Yang Y, Gomez M, Marsh T, Poillet-Perez L, Sawant A, Chen L, Park NR, Jackson SR, Hu Z, Alon N, Liu C, Debnath J, Guan JL, Davidson S, Verzi M, White E", "evidence": [ { "database": "RefSeq", "id": "NP_033956", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033956" } ], "reference": [ { "type": "PubMed", "id": "35537042", "url": "https://glygen.org/publication/PubMed/35537042" } ] }, { "title": "Chemoproteomic and Transcriptomic Analysis Reveals that O-GlcNAc Regulates Mouse Embryonic Stem Cell Fate through the Pluripotency Network.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2023-02-27", "authors": "Hao Yi, Li Xiang, Qin Ke, Shi Yujie, He Yanwen, Zhang Che, Cheng Bo, Zhang Xiwen, Hu Guangyu, Liang Shuyu, Tang Qi, Chen Xing", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9ESK9", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9ESK9" } ], "reference": [ { "type": "PubMed", "id": "36852467", "url": "https://glygen.org/publication/PubMed/36852467" } ] }, { "title": "Stathmin interaction with a putative kinase and coiled-coil-forming protein domains.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1995", "authors": "Camonis J.H., Sobel A., Maucuer A.", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "reference": [ { "type": "PubMed", "id": "7724523", "url": "https://glygen.org/publication/PubMed/7724523" } ] } ], "pathway": [ { "id": "mmu:12421", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:12421", "resource": "KEGG Pathway" }, { "id": "R-MMU-1632852", "name": "Macroautophagy", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1632852", "resource": "Reactome", "description": "Macroautophagy" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZHK4-1", "protein_name": "RB1-inducible coiled-coil 1", "gene_name": "Rb1cc1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": 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"length": 1588 }, "evidence": [ { "id": "45235935", "url": "http://www.informatics.jax.org/homology/45235935", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8TDY2-1", "protein_name": "RB1-inducible coiled-coil protein 1", "gene_name": "RB1CC1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKLYVFLVNTGTTLTFDTELTVQTVADLKHAIQSKYKIAIQHQVLVVNGGECMAADRRVCTYSAGTDTNPIFLFNKEMILCDRPPAIPKTTFSTENDMEIKVEESLMMPAVFHTVASRTQLALEMYEVAKKLCSFCEGLVHDEHLQHQGWAAIMANLEDCSNSYQKLLFKFESIYSNYLQSIEDIKLKLTHLGTAVSVMAKIPLLECLTRHSYRECLGRLDSLPEHEDSEKAEMKRSTELVLSPDMPRTTNESLLTSFPKSVEHVSPDTADAESGKEIRESCQSTVHQQDETTIDTKDGDLPFFNVSLLDWINVQDRPNDVESLVRKCFDSMSRLDPRIIRPFIAECRQTIAKLDNQNMKAIKGLEDRLYALDQMIASCGRLVNEQKELAQGFLANQKRAENLKDASVLPDLCLSHANQLMIMLQNHRKLLDIKQKCTTAKQELANNLHVRLKWCCFVMLHADQDGEKLQALLRLVIELLERVKIVEALSTVPQMYCLAVVEVVRRKMFIKHYREWAGALVKDGKRLYEAEKSKRESFGKLFRKSFLRNRLFRGLDSWPPSFCTQKPRKFDCELPDISLKDLQFLQSFCPSEVQPFLRVPLLCDFEPLHQHVLALHNLVKAAQSLDEMSQTITDLLSEQKASVSQTSPQSASSPRMESTAGITTTTSPRTPPPLTVQDPLCPAVCPLEELSPDSIDAHTFDFETIPHPNIEQTIHQVSLDLDSLAESPESDFMSAVNEFVIEENLSSPNPISDPQSPEMMVESLYSSVINAIDSRRMQDTNVCGKEDFGDHTSLNVQLERCRVVAQDSHFSIQTIKEDLCHFRTFVQKEQCDFSNSLKCTAVEIRNIIEKVKCSLEITLKEKHQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAVICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVENDEKLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARLLEEKKKLEEEVSKLRSSSFVPSPYVATAPELYGACAPELPGESDRSAVETADEGRVDSAMETSMMSVQENIHMLSEEKQRIMLLERTLQLKEEENKRLNQRLMSQSMSSVSSRHSEKIAIRDFQVGDLVLIILDERHDNYVLFTVSPTLYFLHSESLPALDLKPGEGASGASRRPWVLGKVMEKEYCQAKKAQNRFKVPLGTKFYRVKAVSWNKKV", "length": 1594 }, "evidence": [ { "id": "45235935", "url": "http://www.informatics.jax.org/homology/45235935", "database": "MGI" }, { "id": "Q9ESK9", "url": "https://omabrowser.org/oma/group/Q9ESK9/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "molecular adaptor activity", "id": "GO:0060090", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060090", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "pmid": "" }, { "name": "protein kinase binding", "id": "GO:0019901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 22, "go_terms": [ { "name": "autophagosome assembly", "id": "GO:0000045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000045", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "pmid": "" }, { "name": "liver development", "id": "GO:0001889", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001889", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "pmid": "" }, { "name": "positive regulation of protein phosphorylation", "id": "GO:0001934", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001934", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "pmid": "" }, { "name": "protein phosphorylation", "id": "GO:0006468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006468", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "pmid": "" }, { "name": "heart development", "id": "GO:0007507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007507", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "pmid": "" }, { "name": "negative regulation of cell population proliferation", "id": "GO:0008285", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "pmid": "" }, { "name": "negative regulation of apoptotic process", "id": "GO:0043066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "pmid": "" }, { "name": "positive regulation of JNK cascade", "id": "GO:0046330", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046330", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "pmid": "" }, { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "pmid": "" }, { "name": "protein autophosphorylation", "id": "GO:0046777", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046777", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "pmid": "" }, { "name": "autophagy", "id": "GO:0006914", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006914", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "pmid": "" }, { "name": "autophagy of peroxisome", "id": "GO:0030242", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030242", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "pmid": "" }, { "name": "positive regulation of autophagy", "id": "GO:0010508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010508", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "pmid": "" }, { "name": "cell cycle", "id": "GO:0007049", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007049", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "pmid": "" }, { "name": "extrinsic apoptotic signaling pathway", "id": "GO:0097191", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097191", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "pmid": "" }, { "name": "positive regulation of cell size", "id": "GO:0045793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045793", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "pmid": "" }, { "name": "negative regulation of extrinsic apoptotic signaling pathway", "id": "GO:2001237", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001237", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "pmid": "" }, { "name": "autophagy of mitochondrion", "id": "GO:0000422", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000422", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "pmid": "" }, { "name": "piecemeal microautophagy of the nucleus", "id": "GO:0034727", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034727", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "pmid": "" }, { "name": "reticulophagy", "id": "GO:0061709", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061709", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "pmid": "" }, { "name": "glycophagy", "id": "GO:0061723", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061723", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "pmid": "" }, { "name": "regulation of protein lipidation", "id": "GO:1903059", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903059", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 9, "go_terms": [ { "name": "autophagosome membrane", "id": "GO:0000421", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000421", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "pmid": "" }, { "name": "nuclear membrane", "id": "GO:0031965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "pmid": "" }, { "name": "lysosome", "id": "GO:0005764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "pmid": "" }, { "name": "phagophore assembly site membrane", "id": "GO:0034045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034045", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK9", "url": "https://www.uniprot.org/uniprot/Q9ESK9" } ], "pmid": "" }, { "name": "phagophore assembly site", "id": "GO:0000407", "url": 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"site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 3 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": 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