{ "uniprot_canonical_ac": "Q9ESK4-1", "uniprot_ac": "Q9ESK4", "uniprot_id": "ING2_MOUSE", "mass": { "chemical_mass": 32978.0, "monoisotopic_mass": 32978.0 }, "refseq": { "ac": "NP_075992", "name": "inhibitor of growth protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075992" }, "gene_names": [ { "name": "Ing2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q9ESK4", "id": "Q9ESK4" }, { "name": "2810011M06Rik; Ing1l; Ing2b; P33ING2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075992", "id": "NP_075992" }, { "name": "Ing1l", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9ESK4", "id": "Q9ESK4" }, { "name": "Ing2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075992", "id": "NP_075992" } ], "protein_names": [ { "name": "Inhibitor of growth protein 2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q9ESK4" }, { "name": "Inhibitor of growth 1-like protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9ESK4" }, { "name": "inhibitor of growth 1-like protein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075992", "id": "NP_075992" }, { "name": "inhibitor of growth protein 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075992", "id": "NP_075992" }, { "name": "p33ING2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9ESK4" } ], "function": [ { "annotation": "2.0 A resolution structure of the mouse ING2 PHD finger in complex with a histone H3 peptide trimethylated at lysine 4", "evidence": [ { "database": "RefSeq", "id": "NP_075992", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075992" }, { "database": "PubMed", "id": "16728977", "url": "https://glygen.org/publication/PubMed/16728977" } ] }, { "annotation": "ING2 may be involved in the repair and regeneration of organs or tissues and is associated with breast and gynecological carcinogenesis.", "evidence": [ { "database": "RefSeq", "id": "NP_075992", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075992" }, { "database": "PubMed", "id": "26717876", "url": "https://glygen.org/publication/PubMed/26717876" } ] }, { "annotation": "ING2 may play a crucial role in the process of preimplantation embryo development through chromatin regulation.", "evidence": [ { "database": "RefSeq", "id": "NP_075992", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075992" }, { "database": "PubMed", "id": "25672483", "url": "https://glygen.org/publication/PubMed/25672483" } ] }, { "annotation": "Inhibitor of growth 2 regulates the high glucose-induced cell cycle arrest and epithelial-to-mesenchymal transition in renal proximal tubular cells. Erratum:[J Physiol Biochem. 2020 Jun 19;:. PMID: 32562166]", "evidence": [ { "database": "RefSeq", "id": "NP_075992", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075992" }, { "database": "PubMed", "id": "32424454", "url": "https://glygen.org/publication/PubMed/32424454" } ] }, { "annotation": "Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs) (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK4", "url": "https://www.uniprot.org/uniprot/Q9ESK4#function" } ] } ], "disease": [ { "disease_id": "DOID:305", "recommended_name": { "id": "DOID:305", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:305", "name": "carcinoma", "description": "A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells." }, "synonyms": [ { "id": "DOID:305", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:305", "name": "epithelial cancer", "description": "" }, { "id": "DOID:305", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:305", "name": "epithelioma", "description": "" }, { "id": "DOID:305", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:305", "name": "malignant Epithelioma", "description": "" } ], "evidence": [ { "id": "305", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:305" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q9ESK4", "url": "https://www.uniprot.org/uniprot/Q9ESK4" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Ing2", "url": "https://www.uniprot.org/uniprot/Q9ESK4", "locus": { "chromosome": "8", "start_pos": 48120213, "end_pos": 48128591, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000063049", "url": "https://www.ensembl.org/id/ENSMUSG00000063049" } ] } } ], "crossref": [ { "id": "ENSMUSG00000063049", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000063049", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd15683", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15683", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd16861", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16861", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "69260", "url": "https://www.ncbi.nlm.nih.gov/gene/69260", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001965", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001965", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019786", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019786", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019787", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019787", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024610", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024610", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR028651", "url": "https://www.ebi.ac.uk/interpro/entry/IPR028651", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042019", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042019", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:69260", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:69260", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1916510", "url": "http://www.informatics.jax.org/marker/MGI:1916510", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "QMEAHSP", "url": "https://omabrowser.org/oma/group/QMEAHSP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "3140066at2759", "url": "http://www.orthodb.org/?query=3140066at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10333", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10333", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10333:SF37", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10333:SF37", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "1WES", "url": "https://www.rcsb.org/structure/1WES", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "2G6Q", "url": "https://www.rcsb.org/structure/2G6Q", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF12998", "url": "http://pfam.xfam.org/family/PF12998", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q9ESK4", "url": "http://purl.obolibrary.org/obo/PR_Q9ESK4", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-3899300", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-3899300", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-6811555", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6811555", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_075992", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075992", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q9ESK4", "url": "https://www.uniprot.org/uniprot/Q9ESK4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9ESK4-1", "url": "https://www.uniprot.org/uniprot/Q9ESK4-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLGQQQQQQLYSSAALLTGERSRLLSCYVQDYLECVESLPHDMQRNVSVLRELDNKYQETLKEIDDVYEKYKKEDDSNQKKRLQQHLQRALINSQELGDEKIQIVTQMLELVENRARQMELHSQCFQDPAESERASDKSKMDSSQPERSSRRPRRQRTSESRDLCHMTNGIDDCDDQPPKEKRSKSAKKKKRSKAKQEREASPVEFAIDPNEPTYCLCNQVSYGEMIGCDNEQCPIEWFHFSCVSLTYKPKGKWYCPKCRGDNEKTMDKSTEKTKKERRAR", "length": 281, "header": "sp|Q9ESK4-1|ING2_MOUSE Isoform 1 of Inhibitor of growth protein 2 OS=Mus musculus OX=10090 GN=Ing2 PE=1 SV=3 CANONICAL=Q9ESK4-1" }, "isoforms": [ { "isoform_ac": "Q9ESK4-1", "url": "", "sequence": { "sequence": "MLGQQQQQQLYSSAALLTGERSRLLSCYVQDYLECVESLPHDMQRNVSVLRELDNKYQETLKEIDDVYEKYKKEDDSNQKKRLQQHLQRALINSQELGDEKIQIVTQMLELVENRARQMELHSQCFQDPAESERASDKSKMDSSQPERSSRRPRRQRTSESRDLCHMTNGIDDCDDQPPKEKRSKSAKKKKRSKAKQEREASPVEFAIDPNEPTYCLCNQVSYGEMIGCDNEQCPIEWFHFSCVSLTYKPKGKWYCPKCRGDNEKTMDKSTEKTKKERRAR", "length": 281, "header": "sp|Q9ESK4-1|ING2_MOUSE Isoform 1 of Inhibitor of growth protein 2 OS=Mus musculus OX=10090 GN=Ing2 PE=1 SV=3 CANONICAL=Q9ESK4-1" }, "locus": { "chromosome": "8", "start_pos": 48127715, "end_pos": 48121704, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000080353", "url": "https://www.ensembl.org/id/ENSMUST00000080353" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000079226", "url": "https://www.ensembl.org/id/ENSMUSP00000079226" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2.", "journal": "Nature", "date": "2006", "authors": "Pena PV, Davrazou F, Shi X, Walter KL, Verkhusha VV, Gozani O, Zhao R, Kutateladze TG", "evidence": [ { "database": "RefSeq", "id": "NP_075992", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075992" } ], "reference": [ { "type": "PubMed", "id": "16728977", "url": "https://glygen.org/publication/PubMed/16728977" } ] }, { "title": "ING2 (inhibitor of growth protein-2) plays a crucial role in preimplantation development.", "journal": "Zygote (Cambridge, England)", "date": "2016", "authors": "Zhou L, Wang P, Zhang J, Heng BC, Tong GQ", "evidence": [ { "database": "RefSeq", "id": "NP_075992", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075992" } ], "reference": [ { "type": "PubMed", "id": "25672483", "url": "https://glygen.org/publication/PubMed/25672483" } ] }, { "title": "Expression profiles of inhibitor of growth protein 2 in normal and cancer tissues: An immunohistochemical screening analysis.", "journal": "Molecular medicine reports", "date": "2016", "authors": "Zhao S, Yang XF, Gou WF, Lu H, Li H, Zhu ZT, Sun HZ, Zheng HC", "evidence": [ { "database": "RefSeq", "id": "NP_075992", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075992" } ], "reference": [ { "type": "PubMed", "id": "26717876", "url": "https://glygen.org/publication/PubMed/26717876" } ] }, { "title": "Inhibitor of growth 2 regulates the high glucose-induced cell cycle arrest and epithelial-to-mesenchymal transition in renal proximal tubular cells.", "journal": "Journal of physiology and biochemistry", "date": "2020", "authors": "Ma Y, Yan R, Wan Q, Lv B, Yang Y, Lv T, Xin W", "evidence": [ { "database": "RefSeq", "id": "NP_075992", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075992" } ], "reference": [ { "type": "PubMed", "id": "32424454", "url": "https://glygen.org/publication/PubMed/32424454" } ] } ], "pathway": [ { "id": "mmu:69260", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:69260", "resource": "KEGG Pathway" }, { "id": "R-MMU-3899300", "name": "SUMOylation of transcription cofactors", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-3899300", "resource": "Reactome", "description": "SUMOylation of transcription cofactors" }, { "id": "R-MMU-6811555", "name": "PI5P Regulates TP53 Acetylation", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6811555", "resource": "Reactome", "description": "PI5P Regulates TP53 Acetylation" } ], "orthologs": [ { "uniprot_canonical_ac": "A6JPL0-1", "protein_name": "Inhibitor of growth protein", "gene_name": "Ing2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLGQQQQLYSSAALLTGERSRLLTCYVQDYLECVESLPHDMQRNVSVLRELDNKYQETLKEIDDVYEKYKKEDDSNQKKRLQQHLQRALINSQELGDEKIQIVTQMLELVENRARQMELHSQCFQDPAESERASDKSKMDSSQPERSSRRPRRQRTSESRDLCHMTNGIDDCDDQPPKEKKSKSAKKKKRSKAKQEREASPVEFAIDPNEPTYCLCNQVSYGEMIGCDNEQCPIEWFHFSCVSLTYKPKGKWYCPKCRGDSEKTMDKSTEKTRKERRAR", "length": 279 }, "evidence": [ { "id": "45237609", "url": "http://www.informatics.jax.org/homology/45237609", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9H160-1", "protein_name": "Inhibitor of growth protein 2", "gene_name": "ING2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MLGQQQQQLYSSAALLTGERSRLLTCYVQDYLECVESLPHDMQRNVSVLRELDNKYQETLKEIDDVYEKYKKEDDLNQKKRLQQLLQRALINSQELGDEKIQIVTQMLELVENRARQMELHSQCFQDPAESERASDKAKMDSSQPERSSRRPRRQRTSESRDLCHMANGIEDCDDQPPKEKKSKSAKKKKRSKAKQEREASPVEFAIDPNEPTYCLCNQVSYGEMIGCDNEQCPIEWFHFSCVSLTYKPKGKWYCPKCRGDNEKTMDKSTEKTKKDRRSR", "length": 280 }, "evidence": [ { "id": "45237609", "url": "http://www.informatics.jax.org/homology/45237609", "database": "MGI" }, { "id": "Q9ESK4", "url": "https://omabrowser.org/oma/group/Q9ESK4/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 17, "go_terms": [ { "name": "positive regulation of stem cell population maintenance", "id": "GO:1902459", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902459", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK4", "url": "https://www.uniprot.org/uniprot/Q9ESK4" } ], "pmid": "" }, { "name": "negative regulation of stem cell population maintenance", "id": "GO:1902455", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902455", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK4", "url": "https://www.uniprot.org/uniprot/Q9ESK4" } ], "pmid": "" }, { "name": "male germ-line stem cell asymmetric division", "id": "GO:0048133", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048133", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK4", "url": "https://www.uniprot.org/uniprot/Q9ESK4" } ], "pmid": "" }, { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK4", "url": "https://www.uniprot.org/uniprot/Q9ESK4" } ], "pmid": "" }, { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK4", "url": "https://www.uniprot.org/uniprot/Q9ESK4" } ], "pmid": "" }, { "name": "regulation of DNA-templated transcription", "id": "GO:0006355", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006355", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK4", "url": "https://www.uniprot.org/uniprot/Q9ESK4" } ], "pmid": "" }, { "name": "flagellated sperm motility", "id": "GO:0030317", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030317", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK4", "url": "https://www.uniprot.org/uniprot/Q9ESK4" } ], "pmid": "" }, { "name": "negative regulation of cell migration", "id": "GO:0030336", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030336", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK4", "url": "https://www.uniprot.org/uniprot/Q9ESK4" } ], "pmid": "" }, { "name": "spermatid development", "id": "GO:0007286", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007286", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK4", "url": "https://www.uniprot.org/uniprot/Q9ESK4" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK4", "url": "https://www.uniprot.org/uniprot/Q9ESK4" } ], "pmid": "" }, { "name": "positive regulation of histone deacetylation", "id": "GO:0031065", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031065", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK4", "url": "https://www.uniprot.org/uniprot/Q9ESK4" } ], "pmid": "" }, { "name": "positive regulation of transforming growth factor beta receptor signaling pathway", "id": "GO:0030511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030511", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK4", "url": "https://www.uniprot.org/uniprot/Q9ESK4" } ], "pmid": "" }, { "name": "chromatin organization", "id": "GO:0006325", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006325", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK4", "url": "https://www.uniprot.org/uniprot/Q9ESK4" } ], "pmid": "" }, { "name": "seminiferous tubule development", "id": "GO:0072520", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072520", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK4", "url": "https://www.uniprot.org/uniprot/Q9ESK4" } ], "pmid": "" }, { "name": "negative regulation of transforming growth factor beta receptor signaling pathway", "id": "GO:0030512", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030512", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK4", "url": "https://www.uniprot.org/uniprot/Q9ESK4" } ], "pmid": "" }, { "name": "negative regulation of apoptotic signaling pathway", "id": "GO:2001234", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001234", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK4", "url": "https://www.uniprot.org/uniprot/Q9ESK4" } ], "pmid": "" }, { "name": "male meiosis I", "id": "GO:0007141", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007141", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK4", "url": "https://www.uniprot.org/uniprot/Q9ESK4" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK4", "url": "https://www.uniprot.org/uniprot/Q9ESK4" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK4", "url": "https://www.uniprot.org/uniprot/Q9ESK4" } ], "pmid": "" }, { "name": "protein-containing complex binding", "id": "GO:0044877", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044877", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK4", "url": "https://www.uniprot.org/uniprot/Q9ESK4" } ], "pmid": "" }, { "name": "phosphatidylinositol binding", "id": "GO:0035091", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035091", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK4", "url": "https://www.uniprot.org/uniprot/Q9ESK4" } ], "pmid": "" }, { "name": "methylated histone binding", "id": "GO:0035064", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035064", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK4", "url": "https://www.uniprot.org/uniprot/Q9ESK4" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK4", "url": "https://www.uniprot.org/uniprot/Q9ESK4" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK4", "url": "https://www.uniprot.org/uniprot/Q9ESK4" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q9ESK4", "url": 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