The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q4V8J2-1", "Q9EQX9-1", "D3ZXL1-1" ], "evidence": [ { "id": "R-RNO-1169402", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1169402" } ] }, { "id": "R-RNO-202453", "name": "Auto-ubiquitination of TRAF6", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O55173-1", "B5DF45-1", "Q9EQX9-1" ], "evidence": [ { "id": "R-RNO-202453", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-202453" } ] }, { "id": "R-RNO-202534", "name": "Ubiquitination of NEMO by TRAF6", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9QY78-1", "O55173-1", "A0A8I6ANR6-1", "B5DF45-1", "Q9EQX9-1" ], "evidence": [ { "id": "R-RNO-202534", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-202534" } ] }, { "id": "R-RNO-2730904", "name": "Auto-ubiquitination of TRAF6", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9WTQ0-1", "B5DF45-1", "Q9EQX9-1" ], "evidence": [ { "id": "R-RNO-2730904", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2730904" } ] }, { "id": "R-RNO-446877", "name": "TRAF6 is K63 poly-ubiquitinated", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "B5DF45-1", "Q9EQX9-1" ], "evidence": [ { "id": "R-RNO-446877", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-446877" } ] }, { "id": "R-RNO-450187", "name": "TAK1 is activated within the TAK1 complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "B5DF45-1", "Q9EQX9-1", "P0C8E4-1" ], "evidence": [ { "id": "R-RNO-450187", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-450187" } ] }, { "id": "R-RNO-450337", "name": "Activated TAK1 phosphorylates MKK4/MKK7", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q4KSH7-1", "B5DF45-1", "Q9EQX9-1", "G3V783-1", "P0C8E4-1" ], "evidence": [ { "id": "R-RNO-450337", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-450337" } ] }, { "id": "R-RNO-450346", "name": "activated human TAK1 phosphorylates MKK3/MKK6", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "B5DF45-1", "Q9EQX9-1", "G3V783-1", "P0C8E4-1" ], "evidence": [ { "id": "R-RNO-450346", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-450346" } ] }, { "id": "R-RNO-451418", "name": "Pellino ubiquitinates IRAK1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3ZSK3-1", "Q9EQX9-1" ], "evidence": [ { "id": "R-RNO-451418", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-451418" } ] }, { "id": "R-RNO-5607756", "name": "TRAF6 oligomer autoubiquitinates", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "B5DF45-1", "Q9EQX9-1" ], "evidence": [ { "id": "R-RNO-5607756", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5607756" } ] }, { "id": "R-RNO-5607757", "name": "K63polyUb-TRAF6 ubiquitinates TAK1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "B5DF45-1", "Q9EQX9-1", "P0C8E4-1" ], "evidence": [ { "id": "R-RNO-5607757", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5607757" } ] }, { "id": "R-RNO-5682629", "name": "HERC2 facilitates UBE2N:UBE2V2 binding to RNF8", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q99MK2-1", "M0RB75-1", "Q9JIM0-1", "A0A0G2JUC9-1", "Q4KLN8-1", "Q9EQX9-1", "Q9JIL8-1", "A0A0G2K5I7-1", "D4ACL8-1" ], "evidence": [ { "id": "R-RNO-5682629", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5682629" } ] }, { "id": "R-RNO-5682858", "name": "RNF8 and RNF168 ubiquitinate H2AFX", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q99MK2-1", "B2RYR0-1", "M0RB75-1", "Q9JIM0-1", "A0A0G2JUC9-1", "Q4KLN8-1", "Q9EQX9-1", "Q9JIL8-1", "A0A0G2K5I7-1", "D4ACL8-1" ], "evidence": [ { "id": "R-RNO-5682858", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5682858" } ] }, { "id": "R-RNO-5682863", "name": "RNF168 binds DNA DSBs", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q99MK2-1", "B2RYR0-1", "M0RB75-1", "Q9JIM0-1", "A0A0G2JUC9-1", "Q4KLN8-1", "Q9EQX9-1", "Q9JIL8-1", "A0A0G2K5I7-1", "D4ACL8-1" ], "evidence": [ { "id": "R-RNO-5682863", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5682863" } ] }, { "id": "R-RNO-5683077", "name": "RNF8 and RNF168 ubiquitinate KDM4A,B", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q99MK2-1", "B2RYR0-1", "M0RB75-1", "Q9JIM0-1", "A0A0G2JUC9-1", "Q4KLN8-1", "Q9EQX9-1", "Q9JIL8-1", "A0A0G2K5I7-1", "D4ACL8-1" ], "evidence": [ { "id": "R-RNO-5683077", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5683077" } ] }, { "id": "R-RNO-5683384", "name": "UIMC1 and FAM175A bind DNA DSBs", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q99MK2-1", "B2RYR0-1", "Q9JIM0-1", "A0A0G2JUC9-1", "Q4KLN8-1", "Q9EQX9-1", "Q9JIL8-1", "D4ACL8-1" ], "evidence": [ { "id": "R-RNO-5683384", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5683384" } ] }, { "id": "R-RNO-5683385", "name": "Formation of BRCA1-A complex at DNA DSBs", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q99MK2-1", "B2RYR0-1", "Q9JIM0-1", "A0A0G2JUC9-1", "B2RYM5-1", "O54952-1", "Q4KLN8-1", "Q9EQX9-1", "Q9JIL8-1", "Q9QZH2-1", "D4ACL8-1" ], "evidence": [ { "id": "R-RNO-5683385", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5683385" } ] }, { "id": "R-RNO-5683405", "name": "PPP5C dephosphorylates TP53BP1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q99MK2-1", "P53042-1", "B2RYR0-1", "Q9JIM0-1", "A0A0G2JUC9-1", "Q4KLN8-1", "Q9EQX9-1", "Q9JIL8-1", "D4ACL8-1" ], "evidence": [ { "id": "R-RNO-5683405", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5683405" } ] }, { "id": "R-RNO-5683425", "name": "ATM phosphorylates TP53BP1 at DNA DSBs", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q99MK2-1", "B2RYR0-1", "Q9JIM0-1", "A0A0G2JUC9-1", "Q4KLN8-1", "Q9EQX9-1", "Q9JIL8-1", "D4ACL8-1" ], "evidence": [ { "id": "R-RNO-5683425", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5683425" } ] }, { "id": "R-RNO-5683735", "name": "CHEK2 is recruited to DNA DSBs", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q99MK2-1", "B2RYR0-1", "Q9JIM0-1", "A0A0G2JUC9-1", "B2RYM5-1", "O54952-1", "Q4KLN8-1", "Q9EQX9-1", "Q9JIL8-1", "Q9QZH2-1", "D4ACL8-1" ], "evidence": [ { "id": "R-RNO-5683735", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5683735" } ] }, { "id": "R-RNO-5683801", "name": "CHEK2 phosphorylates BRCA1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q99MK2-1", "B2RYR0-1", "Q9JIM0-1", "A0A0G2JUC9-1", "B2RYM5-1", "O54952-1", "Q4KLN8-1", "Q9EQX9-1", "Q9JIL8-1", "Q9QZH2-1", "D4ACL8-1" ], "evidence": [ { "id": "R-RNO-5683801", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5683801" } ] }, { "id": "R-RNO-5684052", "name": "PIAS4 SUMOylates MDC1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q99MK2-1", "B2RYR0-1", "Q9JIM0-1", "A0A0G2JUC9-1", "B2RYM5-1", "O54952-1", "P63281-1", "Q4KLN8-1", "Q9EQX9-1", "Q9JIL8-1", "Q9QZH2-1", "D4ACL8-1" ], "evidence": [ { "id": "R-RNO-5684052", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5684052" } ] }, { "id": "R-RNO-5686685", "name": "RIF1 and PAX1IP bind TP53BP1 at DNA DSBs", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-RNO-480742", "R-RNO-5619395" ], "output_participant_list": [ "R-RNO-5682574", "R-RNO-5682575", "R-RNO-5682577", "R-RNO-5682579", "R-RNO-5682582" ], "enzyme_list": [ "Q99MK2-1", "B2RYR0-1", "Q9JIM0-1", "A0A0G2JUC9-1", "B2RYM5-1", "O54952-1", "Q4KLN8-1", "Q9EQX9-1", "Q9JIL8-1", "Q9QZH2-1", "D4ACL8-1" ], "evidence": [ { "id": "R-RNO-5686685", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5686685" } ] }, { "id": "R-RNO-5686704", "name": "Activated ATM phosphorylates DCLRE1C", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [ "R-RNO-5686708" ], "enzyme_list": [ "Q99MK2-1", "B2RYR0-1", "Q9JIM0-1", "A0A0G2JUC9-1", "Q4KLN8-1", "Q9EQX9-1", "Q9JIL8-1", "Q5XIX3-1", "D4ACL8-1" ], "evidence": [ { "id": "R-RNO-5686704", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5686704" } ] }, { "id": "R-RNO-5686900", "name": "TP53BP1 recruits DCLRE1C to ATM", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q99MK2-1", "B2RYR0-1", "Q9JIM0-1", "A0A0G2JUC9-1", "Q4KLN8-1", "Q9EQX9-1", "Q9JIL8-1", "Q5XIX3-1", "D4ACL8-1" ], "evidence": [ { "id": "R-RNO-5686900", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5686900" } ] }, { "id": "R-RNO-5693551", "name": "Phosphorylation of BRCA1-A complex at multiple sites by ATM", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q99MK2-1", "B2RYR0-1", "Q9JIM0-1", "A0A0G2JUC9-1", "B2RYM5-1", "O54952-1", "Q4KLN8-1", "Q9EQX9-1", "Q9JIL8-1", "Q9QZH2-1", "D4ACL8-1" ], "evidence": [ { "id": "R-RNO-5693551", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5693551" } ] }, { "id": "R-RNO-5693566", "name": "TP53BP1 associates with H4K20Me2 at DNA DSBs", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q99MK2-1", "B2RYR0-1", "Q9JIM0-1", "A0A0G2JUC9-1", "Q4KLN8-1", "Q9EQX9-1", "Q9JIL8-1", "D4ACL8-1" ], "evidence": [ { "id": "R-RNO-5693566", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5693566" } ] }, { "id": "R-RNO-6790487", "name": "RNF111 ubiquitinates SUMOylated XPC", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P27008-1", "Q4G005-1", "D3ZEG9-1", "Q9EQX9-1" ], "evidence": [ { "id": "R-RNO-6790487", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6790487" } ] }, { "id": "R-RNO-688137", "name": "RIP2 is K63 polyubiquitinated", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A0G2K9T1-1", "B5DF45-1", "Q9EQX9-1", "G3V783-1" ], "evidence": [ { "id": "R-RNO-688137", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-688137" } ] }, { "id": "R-RNO-69891", "name": "Phosphorylation and activation of CHEK2 by ATM", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [ "R-RNO-113825" ], "enzyme_list": [ "Q99MK2-1", "B2RYR0-1", "Q9JIM0-1", "A0A0G2JUC9-1", "B2RYM5-1", "O54952-1", "Q4KLN8-1", "Q9EQX9-1", "Q9JIL8-1", "Q9QZH2-1", "D4ACL8-1" ], "evidence": [ { "id": "R-RNO-69891", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-69891" } ] }, { "id": "R-RNO-741386", "name": "RIP2 induces K63-linked ubiquitination of NEMO", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "B5DF45-1", "Q9EQX9-1", "G3V783-1" ], "evidence": [ { "id": "R-RNO-741386", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-741386" } ] }, { "id": "R-RNO-8938815", "name": "RNF152 polyubiquitinates RRAGA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, lysosomal membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D4A723-1", "Q63486-1", "Q9EQX9-1" ], "evidence": [ { "id": "R-RNO-8938815", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8938815" } ] }, { "id": "R-RNO-8938829", "name": "RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, lysosomal membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D4A723-1", "Q63486-1", "Q9EQX9-1" ], "evidence": [ { "id": "R-RNO-8938829", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8938829" } ] }, { "id": "R-RNO-8939323", "name": "RNF181 binds BCL10 and Ubiquitin:E2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61078-1", "P62839-1", "D3ZDK2-1", "Q6AXU4-1", "Q9EQX9-1" ], "evidence": [ { "id": "R-RNO-8939323", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8939323" } ] }, { "id": "R-RNO-8939335", "name": "RNF181 polyubiquinates BCL10", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P61078-1", "P62839-1", "D3ZDK2-1", "Q6AXU4-1", "Q9EQX9-1" ], "evidence": [ { "id": "R-RNO-8939335", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8939335" } ] }, { "id": "R-RNO-8943003", "name": "SHPRH polyubiquitinates monoubiquitinated PCNA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P63149-1", "Q9EQX9-1", "A0JPN0-1" ], "evidence": [ { "id": "R-RNO-8943003", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8943003" } ] }, { "id": "R-RNO-8943007", "name": "SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P63149-1", "Q9EQX9-1", "A0JPN0-1" ], "evidence": [ { "id": "R-RNO-8943007", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8943007" } ] }, { "id": "R-RNO-8943040", "name": "HLTF polyubiquitinates monoubiquitinated PCNA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P63149-1", "Q9EQX9-1", "A0JPN0-1" ], "evidence": [ { "id": "R-RNO-8943040", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8943040" } ] }, { "id": "R-RNO-8943041", "name": "HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P63149-1", "Q9EQX9-1", "A0JPN0-1" ], "evidence": [ { "id": "R-RNO-8943041", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8943041" } ] }, { "id": "R-RNO-8948015", "name": "hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "B5DF45-1", "Q9EQX9-1" ], "evidence": [ { "id": "R-RNO-8948015", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8948015" } ] }, { "id": "R-RNO-8948018", "name": "UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "B5DF45-1", "Q9EQX9-1" ], "evidence": [ { "id": "R-RNO-8948018", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8948018" } ] }, { "id": "R-RNO-8948063", "name": "hp-IRAK1:p-Pellino, IRAK4:p-Pellino bind UBE2N:UBE2V1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A8I6G1H3-1", "D3ZSK3-1", "Q9EQX9-1" ], "evidence": [ { "id": "R-RNO-8948063", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8948063" } ] }, { "id": "R-RNO-8948066", "name": "K63polyUb-IRAK1 dissociates", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3ZSK3-1", "Q9EQX9-1" ], "evidence": [ { "id": "R-RNO-8948066", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8948066" } ] }, { "id": "R-RNO-937050", "name": "Pellino ubiquitinates hp-IRAK1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3ZSK3-1", "B5DF45-1", "Q9EQX9-1" ], "evidence": [ { "id": "R-RNO-937050", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-937050" } ] }, { "id": "R-RNO-9641089", "name": "Parkin binds Ub:UBE2N:UBE2V1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9JK66-1", "Q9EQX9-1" ], "evidence": [ { "id": "R-RNO-9641089", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9641089" } ] }, { "id": "R-RNO-9641096", "name": "Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9JK66-1", "O88767-1", "Q9EQX9-1" ], "evidence": [ { "id": "R-RNO-9641096", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9641096" } ] }, { "id": "R-RNO-9641109", "name": "PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P34158-1", "Q9JK66-1", "O88767-1", "Q9EQX9-1" ], "evidence": [ { "id": "R-RNO-9641109", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9641109" } ] }, { "id": "R-RNO-9641111", "name": "Parkin transfers Ub to misfolded proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P34158-1", "Q9JK66-1", "O88767-1", "Q9EQX9-1" ], "evidence": [ { "id": "R-RNO-9641111", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9641111" } ] }, { "id": "R-RNO-9641127", "name": "Ub:misfolded proteins polymerize to PolyUb:misfolded proteins", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P34158-1",
"Q9JK66-1",
"O88767-1",
"Q9EQX9-1"
],
"evidence": [
{
"id": "R-RNO-9641127",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9641127"
}
]
},
{
"id": "R-RNO-975122",
"name": "Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation
",
"equation": "",
"summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, endosome membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3ZSK3-1", "B5DF45-1", "Q9EQX9-1" ], "evidence": [ { "id": "R-RNO-975122", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-975122" } ] }, { "id": "R-RNO-9758604", "name": "Ubiquitination of IKBKG by TRAF6", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9QY78-1", "Q6AYC7-1", "A0A8I6ANR6-1", "B5DF45-1", "Q9EQX9-1", "P0C8E4-1" ], "evidence": [ { "id": "R-RNO-9758604", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-9758604" } ] }, { "id": "R-RNO-983140", "name": "Transfer of Ub from E2 to substrate and release of E2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6AYH3-1", "F1LP64-1", "Q5BK82-1", "Q91ZY8-1", "O88846-1", "Q9JK66-1", "Q62921-1", "D3ZXK7-1", "Q2TL32-1", "Q8K4S7-1", "Q62940-1", "P63149-1", "B2GV24-1", "P61078-1", "Q3T1H6-1", "Q6P7A2-1", "Q71F54-1", "Q8R4T2-1", "A0A0G2JUC9-1", "A0A0G2K612-1", "D3ZHB7-1", "A0A8I5YBG5-1", "G3V930-1", "D3ZJB8-1", "D3ZLS5-1", "D3ZXM0-1", "D4ABK2-1", "D4ADD3-1", "D3ZDI6-1", "Q5PQN1-1", "D3Z8X6-1", "D4ACF2-1", "A0A0G2K9T1-1", "D4A1V8-1", "F1M9Q3-1", "Q66H79-1", "Q920M9-1", "B1H278-1", "B5DFI8-1", "P62839-1", "Q4V8J2-1", "Q63364-1", "Q6MFZ5-1", "Q810I1-1", "Q91Z63-1", "D3ZBM4-1", "D3ZDK2-1", "P62255-1", "Q3B7D1-1", "Q5U203-1", "Q6J2U6-1", "Q99PD2-1", "Q9EQX9-1", "D3ZVM4-1", "D3ZBM7-1", "Q5XIQ4-1", "Q68LP1-1", "Q6Y290-1", "F1M3F2-1", "A0A0G2K0E7-1", "A0A0G2QC40-1", "D3ZFK0-1", "A0A0G2K6H9-1", "A0A0G2K735-1", "A0A8I5ZZN6-1", "D3ZS02-1", "F1M7B8-1" ], "evidence": [ { "id": "R-RNO-983140", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983140" } ] }, { "id": "R-RNO-983152", "name": "Transfer of ubiquitin from E1 to E2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P63149-1", "P61078-1", "B5DFI8-1", "P62839-1", "Q4V8J2-1", "Q99MI7-1", "D3ZDK2-1", "P62255-1", "Q3B7D1-1", "Q5U203-1", "Q5U300-1", "Q9EQX9-1", "D4A8H3-1", "A0A0G2K735-1" ], "evidence": [ { "id": "R-RNO-983152", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983152" } ] }, { "id": "R-RNO-983156", "name": "Polyubiquitination of substrate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6AYH3-1", "F1LP64-1", "Q5BK82-1", "Q91ZY8-1", "O88846-1", "Q9JK66-1", "Q62921-1", "D3ZXK7-1", "Q2TL32-1", "Q8K4S7-1", "Q62940-1", "P63149-1", "B2GV24-1", "P61078-1", "Q3T1H6-1", "Q6P7A2-1", "Q71F54-1", "Q8R4T2-1", "A0A0G2JUC9-1", "A0A0G2K612-1", "D3ZHB7-1", "A0A8I5YBG5-1", "G3V930-1", "D3ZJB8-1", "D3ZLS5-1", "D3ZXM0-1", "D4ABK2-1", "D4ADD3-1", "D3ZDI6-1", "Q5PQN1-1", "D3Z8X6-1", "D4ACF2-1", "A0A0G2K9T1-1", "D4A1V8-1", "F1M9Q3-1", "Q66H79-1", "Q920M9-1", "B1H278-1", "B5DFI8-1", "P62839-1", "Q4V8J2-1", "Q63364-1", "Q6MFZ5-1", "Q810I1-1", "Q91Z63-1", "D3ZBM4-1", "D3ZDK2-1", "P62255-1", "Q3B7D1-1", "Q5U203-1", "Q6J2U6-1", "Q99PD2-1", "Q9EQX9-1", "D3ZVM4-1", "D3ZBM7-1", "Q5XIQ4-1", "Q68LP1-1", "Q6Y290-1", "F1M3F2-1", "A0A0G2K0E7-1", "A0A0G2QC40-1", "D3ZFK0-1", "A0A0G2K6H9-1", "A0A0G2K735-1", "A0A8I5ZZN6-1", "D3ZS02-1", "F1M7B8-1" ], "evidence": [ { "id": "R-RNO-983156", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983156" } ] }, { "id": "R-RNO-983157", "name": "Interaction of E3 with substrate and E2-Ub complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6AYH3-1", "F1LP64-1", "Q5BK82-1", "Q91ZY8-1", "O88846-1", "Q9JK66-1", "Q62921-1", "D3ZXK7-1", "Q2TL32-1", "Q8K4S7-1", "Q62940-1", "P63149-1", "B2GV24-1", "P61078-1", "Q3T1H6-1", "Q6P7A2-1", "Q71F54-1", "Q8R4T2-1", "A0A0G2JUC9-1", "A0A0G2K612-1", "D3ZHB7-1", "A0A8I5YBG5-1", "G3V930-1", "D3ZJB8-1", "D3ZLS5-1", "D3ZXM0-1", "D4ABK2-1", "D4ADD3-1", "D3ZDI6-1", "Q5PQN1-1", "D3Z8X6-1", "D4ACF2-1", "A0A0G2K9T1-1", "D4A1V8-1", "F1M9Q3-1", "Q66H79-1", "Q920M9-1", "B1H278-1", "B5DFI8-1", "P62839-1", "Q4V8J2-1", "Q63364-1", "Q6MFZ5-1", "Q810I1-1", "Q91Z63-1", "D3ZBM4-1", "D3ZDK2-1", "P62255-1", "Q3B7D1-1", "Q5U203-1", "Q6J2U6-1", "Q99PD2-1", "Q9EQX9-1", "D3ZVM4-1", "D3ZBM7-1", "Q5XIQ4-1", "Q68LP1-1", "Q6Y290-1", "F1M3F2-1", "A0A0G2K0E7-1", "A0A0G2QC40-1", "D3ZFK0-1", "A0A0G2K6H9-1", "A0A0G2K735-1", "A0A8I5ZZN6-1", "D3ZS02-1", "F1M7B8-1" ], "evidence": [ { "id": "R-RNO-983157", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-983157" } ] } ], "reaction_participants": [ { "participant_id": "R-RNO-113825", "participant_name": "phospho-Chek2 [nucleoplasm]", "crossref": [ { "id": "Q9R019", "database": "UniProt", "url": "" }, { "id": "ENSRNOG00000037509", "database": "Ensembl", "url": "" }, { "id": "XP_006249582.1", "database": "RefSeq", "url": "" }, { "id": "621543", "database": "RGD", "url": "" }, { "id": "XP_006249581.1", "database": "RefSeq", "url": "" }, { "id": "ENSRNOT00000085591", "database": "Ensembl", "url": "" }, { "id": "XP_006249580.1", "database": "RefSeq", "url": "" }, { "id": "XP_006249583.1", "database": "RefSeq", "url": "" }, { "id": "NP_446129.1", "database": "RefSeq", "url": "" }, { "id": "ENSRNOP00000074651", "database": "Ensembl", "url": "" } ] }, { "participant_id": "R-RNO-480742", "participant_name": "Rif1 [nucleoplasm]", "crossref": [ { "id": "ENSRNOT00000090575", "database": "Ensembl", "url": "" }, { "id": "ENSRNOP00000075681", "database": "Ensembl", "url": "" }, { "id": "A0A0G2KB73", "database": "UniProt", "url": "" }, { "id": "1562474", "database": "RGD", "url": "" }, { "id": "ENSRNOG00000054901", "database": "Ensembl", "url": "" } ] }, { "participant_id": "R-RNO-5619395", "participant_name": "Paxip1 [nucleoplasm]", "crossref": [ { "id": "ENSRNOG00000007131", "database": "Ensembl", "url": "" }, { "id": "1307547", "database": "RGD", "url": "" }, { "id": "D3ZSX6", "database": "UniProt", "url": "" }, { "id": "ENSRNOT00000009439", "database": "Ensembl", "url": "" }, { "id": "ENSRNOP00000009439", "database": "Ensembl", "url": "" } ] }, { "participant_id": "R-RNO-5682574", "participant_name": "UIMC1 [nucleoplasm]", "crossref": [ { "id": "Q5PQK4", "database": "PRO", "url": "" }, { "id": "NP_001013906.1", "database": "RefSeq", "url": "" }, { "id": "XP_017455963.1", "database": "RefSeq", "url": "" }, { "id": "1307009", "database": "RGD", "url": "" }, { "id": "Q5PQK4", "database": "UniProt", "url": "" } ] }, { "participant_id": "R-RNO-5682575", "participant_name": "phospho-ABRAXAS1 [nucleoplasm]", "crossref": [ { "id": "Q5I0F1", "database": "UniProt", "url": "" }, { "id": "ENSG00000163322", "database": "OpenTargets", "url": "" }, { "id": "NP_001009633.1", "database": "RefSeq", "url": "" }, { "id": "Q5I0F1", "database": "PRO", "url": "" }, { "id": "1305287", "database": "RGD", "url": "" } ] }, { "participant_id": "R-RNO-5682577", "participant_name": "BRCC3 [nucleoplasm]", "crossref": [ { "id": "ENSRNOG00000048061", "database": "Ensembl", "url": "" }, { "id": "B2RYM5", "database": "PRO", "url": "" }, { "id": "NP_001120772.1", "database": "RefSeq", "url": "" }, { "id": "ENSRNOT00000071068", "database": "Ensembl", "url": "" }, { "id": "ENSRNOP00000066438", "database": "Ensembl", "url": "" }, { "id": "1588543", "database": "RGD", "url": "" }, { "id": "B2RYM5", "database": "UniProt", "url": "" } ] }, { "participant_id": "R-RNO-5682579", "participant_name": "Babam2 [nucleoplasm]", "crossref": [ { "id": "NP_954891.1", "database": "RefSeq", "url": "" }, { "id": "XP_017449703.1", "database": "RefSeq", "url": "" }, { "id": "ENSRNOG00000004364", "database": "Ensembl", "url": "" }, { "id": "ENSRNOP00000005855", "database": "Ensembl", "url": "" }, { "id": "ENSRNOT00000005855", "database": "Ensembl", "url": "" }, { "id": "735111", "database": "RGD", "url": "" }, { "id": "XP_006239864.1", "database": "RefSeq", "url": "" }, { "id": "Q6P7Q1", "database": "PRO", "url": "" }, { "id": "Q6P7Q1", "database": "UniProt", "url": "" } ] }, { "participant_id": "R-RNO-5682582", "participant_name": "Babam1 [nucleoplasm]", "crossref": [ { "id": "ENSRNOT00000022938", "database": "Ensembl", "url": "" }, { "id": "NP_001006965.1", "database": "RefSeq", "url": "" }, { "id": "ENSRNOG00000017071", "database": "Ensembl", "url": "" }, { "id": "Q5XIJ6", "database": "PRO", "url": "" }, { "id": "XP_006252919.1", "database": "RefSeq", "url": "" }, { "id": "1359516", "database": "RGD", "url": "" }, { "id": "ENSRNOP00000022938", "database": "Ensembl", "url": "" }, { "id": "Q5XIJ6", "database": "UniProt", "url": "" } ] }, { "participant_id": "R-RNO-5686708", "participant_name": "phospho-Dclre1c [nucleoplasm]", "crossref": [ { "id": "Q5XIX3", "database": "UniProt", "url": "" }, { "id": "708574", "database": "RGD", "url": "" }, { "id": "Q5XIX3", "database": "PRO", "url": "" }, { "id": "NP_671486.2", "database": "RefSeq", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A0G2JUC9", "gene_name": "Herc2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A0G2JUC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JUC9" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "A0A0G2JUC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JUC9" } ] } ] }, { "uniprot_ac": "A0A0G2K0E7", "gene_name": "Ube3b", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A0G2K0E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K0E7" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "A0A0G2K0E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K0E7" } ] } ] }, { "uniprot_ac": "A0A0G2K5I7", "gene_name": "Kdm4a", "activity": [ { "ec_number": "1.14.11.66", "activity": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + 2 succinate.", "evidence": [ { "id": "A0A0G2K5I7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K5I7" } ] }, { "ec_number": "1.14.11.66", "activity": "", "evidence": [ { "id": "A0A0G2K5I7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K5I7" } ] } ] }, { "uniprot_ac": "A0A0G2K612", "gene_name": "Smurf1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A0G2K612", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K612" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "A0A0G2K612", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K612" } ] } ] }, { "uniprot_ac": "A0A0G2K6H9", "gene_name": "Rnf19b", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "A0A0G2K6H9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K6H9" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "A0A0G2K6H9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K6H9" } ] } ] }, { "uniprot_ac": "A0A0G2K735", "gene_name": "Uba7", "activity": [ { "ec_number": "6.2.1.45", "activity": "ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.", "evidence": [ { "id": "A0A0G2K735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K735" } ] }, { "ec_number": "6.2.1.45", "activity": "", "evidence": [ { "id": "A0A0G2K735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K735" } ] } ] }, { "uniprot_ac": "A0A0G2K9T1", "gene_name": "Itch", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A0G2K9T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K9T1" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "A0A0G2K9T1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K9T1" } ] } ] }, { "uniprot_ac": "A0A0G2QC40", "gene_name": "Mkrn1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A0G2QC40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2QC40" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A0G2QC40", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2QC40" } ] } ] }, { "uniprot_ac": "A0A8I5YBG5", "gene_name": "Ubr2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A8I5YBG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5YBG5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A8I5YBG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5YBG5" } ] } ] }, { "uniprot_ac": "A0A8I5ZZN6", "gene_name": "Ubr1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0A8I5ZZN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZZN6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0A8I5ZZN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZZN6" } ] } ] }, { "uniprot_ac": "A0A8I6ANR6", "gene_name": "Chuk", "activity": [ { "ec_number": "2.7.11.10", "activity": "ATP + L-seryl-[I-kappa-B protein] = ADP + H(+) + O-phospho-L-seryl-[I-kappa-B protein].", "evidence": [ { "id": "A0A8I6ANR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6ANR6" } ] }, { "ec_number": "2.7.11.10", "activity": "", "evidence": [ { "id": "A0A8I6ANR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6ANR6" } ] } ] }, { "uniprot_ac": "A0A8I6G1H3", "gene_name": "Irak4", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I6G1H3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6G1H3" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "A0A8I6G1H3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6G1H3" } ] } ] }, { "uniprot_ac": "A0JPN0", "gene_name": "Rad18", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A0JPN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0JPN0" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A0JPN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0JPN0" } ] } ] }, { "uniprot_ac": "B1H278", "gene_name": "Trim11", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "B1H278", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1H278" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "B1H278", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1H278" } ] } ] }, { "uniprot_ac": "B2GV24", "gene_name": "Ufl1", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "B2GV24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2GV24" } ] } ] }, { "uniprot_ac": "B2RYM5", "gene_name": "Brcc3", "activity": [ { "ec_number": "3.4.19.-", "activity": "", "evidence": [ { "id": "B2RYM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RYM5" } ] } ] }, { "uniprot_ac": "B2RYR0", "gene_name": "Rnf168", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "B2RYR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RYR0" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "B2RYR0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RYR0" } ] } ] }, { "uniprot_ac": "B5DF45", "gene_name": "Traf6", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "B5DF45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B5DF45" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "B5DF45", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B5DF45" } ] } ] }, { "uniprot_ac": "B5DFI8", "gene_name": "Ube2s", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "B5DFI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B5DFI8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "B5DFI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B5DFI8" } ] } ] }, { "uniprot_ac": "D3Z8X6", "gene_name": "Dtx3l", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "D3Z8X6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z8X6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "D3Z8X6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z8X6" } ] } ] }, { "uniprot_ac": "D3ZBM4", "gene_name": "Rnf182", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "D3ZBM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBM4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "D3ZBM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBM4" } ] } ] }, { "uniprot_ac": "D3ZBM7", "gene_name": "Hace1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "D3ZBM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBM7" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "D3ZBM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBM7" } ] } ] }, { "uniprot_ac": "D3ZDI6", "gene_name": "Mylip", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "D3ZDI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDI6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "D3ZDI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDI6" } ] } ] }, { "uniprot_ac": "D3ZDK2", "gene_name": "Ube2d1", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "D3ZDK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDK2" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "D3ZDK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDK2" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "D3ZDK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDK2" } ] } ] }, { "uniprot_ac": "D3ZEG9", "gene_name": "Ercc2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZEG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZEG9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZEG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZEG9" } ] } ] }, { "uniprot_ac": "D3ZFK0", "gene_name": "Rnf144b", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "D3ZFK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZFK0" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "D3ZFK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZFK0" } ] } ] }, { "uniprot_ac": "D3ZHB7", "gene_name": "Ube3c", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "D3ZHB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZHB7" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "D3ZHB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZHB7" } ] } ] }, { "uniprot_ac": "D3ZJB8", "gene_name": "Arih2", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "D3ZJB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZJB8" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "D3ZJB8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZJB8" } ] } ] }, { "uniprot_ac": "D3ZLS5", "gene_name": "Hectd1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "D3ZLS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZLS5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "D3ZLS5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZLS5" } ] } ] }, { "uniprot_ac": "D3ZS02", "gene_name": "Cbll1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "D3ZS02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZS02" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "D3ZS02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZS02" } ] } ] }, { "uniprot_ac": "D3ZSK3", "gene_name": "Peli2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "D3ZSK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZSK3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "D3ZSK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZSK3" } ] } ] }, { "uniprot_ac": "D3ZVM4", "gene_name": "Trim71", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "D3ZVM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZVM4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "D3ZVM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZVM4" } ] } ] }, { "uniprot_ac": "D3ZXK7", "gene_name": "Rnf123", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "D3ZXK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZXK7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "D3ZXK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZXK7" } ] } ] }, { "uniprot_ac": "D3ZXL1", "gene_name": "Arih1", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "D3ZXL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZXL1" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "D3ZXL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZXL1" } ] } ] }, { "uniprot_ac": "D3ZXM0", "gene_name": "Rnf19a", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "D3ZXM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZXM0" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "D3ZXM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZXM0" } ] } ] }, { "uniprot_ac": "D4A1V8", "gene_name": "Dzip3", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "D4A1V8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A1V8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "D4A1V8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A1V8" } ] } ] }, { "uniprot_ac": "D4A723", "gene_name": "Rnf152", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "D4A723", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A723" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "D4A723", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A723" } ] } ] }, { "uniprot_ac": "D4A8H3", "gene_name": "Uba6", "activity": [ { "ec_number": "6.2.1.45", "activity": "ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.", "evidence": [ { "id": "D4A8H3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A8H3" } ] }, { "ec_number": "6.2.1.45", "activity": "", "evidence": [ { "id": "D4A8H3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A8H3" } ] } ] }, { "uniprot_ac": "D4ABK2", "gene_name": "Rnf217", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "D4ABK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ABK2" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "D4ABK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ABK2" } ] } ] }, { "uniprot_ac": "D4ACF2", "gene_name": "Trim21", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "D4ACF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ACF2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "D4ACF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ACF2" } ] } ] }, { "uniprot_ac": "D4ACL8", "gene_name": "Atm", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "D4ACL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ACL8" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "D4ACL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ACL8" } ] } ] }, { "uniprot_ac": "D4ADD3", "gene_name": "Hecw2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "D4ADD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ADD3" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "D4ADD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ADD3" } ] } ] }, { "uniprot_ac": "F1LP64", "gene_name": "Trip12", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1LP64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LP64" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1LP64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LP64" } ] } ] }, { "uniprot_ac": "F1M3F2", "gene_name": "Smurf2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1M3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M3F2" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1M3F2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M3F2" } ] } ] }, { "uniprot_ac": "F1M7B8", "gene_name": "Ube3a", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1M7B8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M7B8" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "F1M7B8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M7B8" } ] } ] }, { "uniprot_ac": "F1M9Q3", "gene_name": "Ltn1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "F1M9Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M9Q3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "F1M9Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M9Q3" } ] } ] }, { "uniprot_ac": "G3V783", "gene_name": "Ripk2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "G3V783", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V783" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "G3V783", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V783" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "G3V783", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V783" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3V783", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V783" } ] } ] }, { "uniprot_ac": "G3V930", "gene_name": "Rnf41", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "G3V930", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V930" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "G3V930", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V930" } ] } ] }, { "uniprot_ac": "M0RB75", "gene_name": "Kdm4b", "activity": [ { "ec_number": "1.14.11.66", "activity": "2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O2 = 2 CO2 + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + 2 succinate.", "evidence": [ { "id": "M0RB75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RB75" } ] }, { "ec_number": "1.14.11.66", "activity": "", "evidence": [ { "id": "M0RB75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RB75" } ] } ] }, { "uniprot_ac": "O54952", "gene_name": "Brca1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O54952", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54952" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "O54952", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54952" } ] } ] }, { "uniprot_ac": "O55173", "gene_name": "Pdpk1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O55173", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55173" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O55173", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55173" } ] } ] }, { "uniprot_ac": "O88767", "gene_name": "Park7", "activity": [ { "ec_number": "3.5.1.124", "activity": "H2O + S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein] = H(+) + L-cysteinyl-[protein] + lactate.", "evidence": [ { "id": "O88767", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88767" } ] }, { "ec_number": "3.5.1.124", "activity": "", "evidence": [ { "id": "O88767", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88767" } ] }, { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "O88767", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88767" } ] }, { "ec_number": "3.5.1.-", "activity": "", "evidence": [ { "id": "O88767", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88767" } ] } ] }, { "uniprot_ac": "O88846", "gene_name": "Rnf4", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O88846", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88846" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "O88846", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88846" } ] } ] }, { "uniprot_ac": "P0C8E4", "gene_name": "Map3k7", "activity": [ { "ec_number": "2.7.11.25", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P0C8E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C8E4" } ] }, { "ec_number": "2.7.11.25", "activity": "", "evidence": [ { "id": "P0C8E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C8E4" } ] } ] }, { "uniprot_ac": "P27008", "gene_name": "Parp1", "activity": [ { "ec_number": "2.4.2.-", "activity": "", "evidence": [ { "id": "P27008", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27008" } ] }, { "ec_number": "2.4.2.30", "activity": "NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).", "evidence": [ { "id": "P27008", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27008" } ] }, { "ec_number": "2.4.2.30", "activity": "", "evidence": [ { "id": "P27008", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27008" } ] } ] }, { "uniprot_ac": "P34158", "gene_name": "Cftr", "activity": [ { "ec_number": "5.6.1.6", "activity": "ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.", "evidence": [ { "id": "P34158", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34158" } ] }, { "ec_number": "5.6.1.6", "activity": "", "evidence": [ { "id": "P34158", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34158" } ] } ] }, { "uniprot_ac": "P53042", "gene_name": "Ppp5c", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P53042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53042" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P53042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53042" } ] } ] }, { "uniprot_ac": "P61078", "gene_name": "Ube2d3", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P61078", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61078" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P61078", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61078" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P61078", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61078" } ] } ] }, { "uniprot_ac": "P62255", "gene_name": "Ube2g1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P62255", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62255" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P62255", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62255" } ] } ] }, { "uniprot_ac": "P62839", "gene_name": "Ube2d2", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P62839", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62839" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P62839", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62839" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P62839", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62839" } ] } ] }, { "uniprot_ac": "P63149", "gene_name": "Ube2b", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P63149", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63149" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P63149", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63149" } ] } ] }, { "uniprot_ac": "P63281", "gene_name": "Ube2i", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "P63281", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63281" } ] } ] }, { "uniprot_ac": "Q2TL32", "gene_name": "Ubr4", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q2TL32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2TL32" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q2TL32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2TL32" } ] } ] }, { "uniprot_ac": "Q3B7D1", "gene_name": "Ube2z", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q3B7D1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3B7D1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q3B7D1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3B7D1" } ] } ] }, { "uniprot_ac": "Q3T1H6", "gene_name": "Ube3d", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q3T1H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3T1H6" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q3T1H6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3T1H6" } ] } ] }, { "uniprot_ac": "Q4G005", "gene_name": "Ercc3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q4G005", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4G005" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q4G005", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4G005" } ] } ] }, { "uniprot_ac": "Q4KLN8", "gene_name": "Rnf8", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q4KLN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KLN8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q4KLN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KLN8" } ] } ] }, { "uniprot_ac": "Q4KSH7", "gene_name": "Map2k7", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q4KSH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KSH7" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q4KSH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KSH7" } ] } ] }, { "uniprot_ac": "Q4V8J2", "gene_name": "Ube2l6", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q4V8J2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4V8J2" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q4V8J2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4V8J2" } ] } ] }, { "uniprot_ac": "Q5BK82", "gene_name": "Trim69", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5BK82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5BK82" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q5BK82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5BK82" } ] } ] }, { "uniprot_ac": "Q5PQN1", "gene_name": "Herc4", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5PQN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5PQN1" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q5PQN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5PQN1" } ] } ] }, { "uniprot_ac": "Q5U203", "gene_name": "Ube2f", "activity": [ { "ec_number": "2.3.2.32", "activity": "S-[NEDD8-protein]-yl-[E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin]-L-lysine = [E2 NEDD8-conjugating enzyme]-L-cysteine + N(6)-[NEDD8-protein]-yl-[cullin]-L-lysine.", "evidence": [ { "id": "Q5U203", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U203" } ] }, { "ec_number": "2.3.2.32", "activity": "", "evidence": [ { "id": "Q5U203", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U203" } ] } ] }, { "uniprot_ac": "Q5U300", "gene_name": "Uba1", "activity": [ { "ec_number": "6.2.1.45", "activity": "ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.", "evidence": [ { "id": "Q5U300", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U300" } ] }, { "ec_number": "6.2.1.45", "activity": "", "evidence": [ { "id": "Q5U300", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U300" } ] } ] }, { "uniprot_ac": "Q5XIQ4", "gene_name": "Mgrn1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5XIQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XIQ4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q5XIQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XIQ4" } ] } ] }, { "uniprot_ac": "Q5XIX3", "gene_name": "Dclre1c", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "Q5XIX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XIX3" } ] } ] }, { "uniprot_ac": "Q62921", "gene_name": "Rbck1", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "Q62921", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62921" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "Q62921", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62921" } ] } ] }, { "uniprot_ac": "Q62940", "gene_name": "Nedd4", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q62940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62940" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q62940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62940" } ] } ] }, { "uniprot_ac": "Q63364", "gene_name": "Pja2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q63364", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63364" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q63364", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63364" } ] } ] }, { "uniprot_ac": "Q63486", "gene_name": "Rraga", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "Q63486", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63486" } ] } ] }, { "uniprot_ac": "Q66H79", "gene_name": "Trim32", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q66H79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q66H79" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q66H79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q66H79" } ] } ] }, { "uniprot_ac": "Q68LP1", "gene_name": "Mib2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q68LP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q68LP1" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q68LP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q68LP1" } ] } ] }, { "uniprot_ac": "Q6AXU4", "gene_name": "Rnf181", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6AXU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AXU4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q6AXU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AXU4" } ] } ] }, { "uniprot_ac": "Q6AYC7", "gene_name": "Usp18", "activity": [ { "ec_number": "3.4.19.12", "activity": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).", "evidence": [ { "id": "Q6AYC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AYC7" } ] }, { "ec_number": "3.4.19.12", "activity": "", "evidence": [ { "id": "Q6AYC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AYC7" } ] } ] }, { "uniprot_ac": "Q6AYH3", "gene_name": "Rnf34", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6AYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AYH3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q6AYH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AYH3" } ] } ] }, { "uniprot_ac": "Q6J2U6", "gene_name": "Rnf114", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6J2U6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6J2U6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q6J2U6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6J2U6" } ] } ] }, { "uniprot_ac": "Q6MFZ5", "gene_name": "Trim39", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6MFZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6MFZ5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q6MFZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6MFZ5" } ] } ] }, { "uniprot_ac": "Q6P7A2", "gene_name": "Ube4a", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6P7A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P7A2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q6P7A2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P7A2" } ] } ] }, { "uniprot_ac": "Q6Y290", "gene_name": "Rnf130", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6Y290", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6Y290" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q6Y290", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6Y290" } ] } ] }, { "uniprot_ac": "Q71F54", "gene_name": "Sh3rf1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q71F54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q71F54" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q71F54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q71F54" } ] } ] }, { "uniprot_ac": "Q810I1", "gene_name": "Trim50", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q810I1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q810I1" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q810I1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q810I1" } ] } ] }, { "uniprot_ac": "Q8K4S7", "gene_name": "Cblb", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8K4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K4S7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8K4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K4S7" } ] } ] }, { "uniprot_ac": "Q8R4T2", "gene_name": "Siah2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8R4T2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R4T2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8R4T2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R4T2" } ] } ] }, { "uniprot_ac": "Q91Z63", "gene_name": "Trim63", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q91Z63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91Z63" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q91Z63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91Z63" } ] } ] }, { "uniprot_ac": "Q91ZY8", "gene_name": "Trim9", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q91ZY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91ZY8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q91ZY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91ZY8" } ] } ] }, { "uniprot_ac": "Q920M9", "gene_name": "Siah1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q920M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q920M9" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q920M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q920M9" } ] } ] }, { "uniprot_ac": "Q99MI7", "gene_name": "Uba3", "activity": [ { "ec_number": "6.2.1.64", "activity": "ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.", "evidence": [ { "id": "Q99MI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99MI7" } ] }, { "ec_number": "6.2.1.64", "activity": "", "evidence": [ { "id": "Q99MI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99MI7" } ] } ] }, { "uniprot_ac": "Q99MK2", "gene_name": "Kat5", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "Q99MK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99MK2" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "Q99MK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99MK2" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q99MK2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99MK2" } ] } ] }, { "uniprot_ac": "Q99PD2", "gene_name": "Rnf138", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q99PD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99PD2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q99PD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99PD2" } ] } ] }, { "uniprot_ac": "Q9EQX9", "gene_name": "Ube2n", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q9EQX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9EQX9" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q9EQX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9EQX9" } ] } ] }, { "uniprot_ac": "Q9JIL8", "gene_name": "Rad50", "activity": [ { "ec_number": "3.6.-.-", "activity": "", "evidence": [ { "id": "Q9JIL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JIL8" } ] } ] }, { "uniprot_ac": "Q9JIM0", "gene_name": "Mre11", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "Q9JIM0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JIM0" } ] } ] }, { "uniprot_ac": "Q9JK66", "gene_name": "Prkn", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "Q9JK66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JK66" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "Q9JK66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JK66" } ] }, { "ec_number": "6.3.2.19", "activity": "", "evidence": [ { "id": "Q9JK66", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JK66" } ] } ] }, { "uniprot_ac": "Q9QY78", "gene_name": "Ikbkb", "activity": [ { "ec_number": "2.7.11.10", "activity": "ATP + L-seryl-[I-kappa-B protein] = ADP + H(+) + O-phospho-L-seryl-[I-kappa-B protein].", "evidence": [ { "id": "Q9QY78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QY78" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9QY78", "database": "UniProtKB", "url": 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