{ "uniprot_canonical_ac": "Q9EPK7-1", "uniprot_ac": "Q9EPK7", "uniprot_id": "XPO7_MOUSE", "mass": { "chemical_mass": 123810.0, "monoisotopic_mass": 123810.0 }, "refseq": { "ac": "NP_075532", "name": "exportin-7 isoform 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075532" }, "gene_names": [ { "name": "Xpo7", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q9EPK7", "id": "Q9EPK7" }, { "name": "4930506C02Rik; exp7; Ranbp16", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075532", "id": "NP_075532" }, { "name": "Kiaa0745", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9EPK7", "id": "Q9EPK7" }, { "name": "Ranbp16", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9EPK7", "id": "Q9EPK7" }, { "name": "Xpo7", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075532", "id": "NP_075532" } ], "protein_names": [ { "name": "Exportin-7", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q9EPK7" }, { "name": "Exp7", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9EPK7" }, { "name": "Ran-binding protein 16", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9EPK7" }, { "name": "exportin-7 isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075532", "id": "NP_075532" }, { "name": "ran-binding protein 16; RAN binding protein 16", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075532", "id": "NP_075532" } ], "function": [ { "annotation": "An In Vivo Model for Elucidating the Role of an Erythroid-Specific Isoform of Nuclear Export Protein Exportin 7 (Xpo7) in Murine Erythropoiesis.", "evidence": [ { "database": "RefSeq", "id": "NP_075532", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075532" }, { "database": "PubMed", "id": "35973480", "url": "https://glygen.org/publication/PubMed/35973480" } ] }, { "annotation": "Exportin XPO7 acts as an oncogenic factor in prostate cancer via upregulation of TCF3.", "evidence": [ { "database": "RefSeq", "id": "NP_075532", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075532" }, { "database": "PubMed", "id": "37000263", "url": "https://glygen.org/publication/PubMed/37000263" } ] }, { "annotation": "Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q9EPK7", "url": "https://www.uniprot.org/uniprot/Q9EPK7#function" } ] }, { "annotation": "MiR-181a is down-regulated during erythroid development and its expression inversely correlated with Xpo7 induction.", "evidence": [ { "database": "RefSeq", "id": "NP_075532", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075532" }, { "database": "PubMed", "id": "29567782", "url": "https://glygen.org/publication/PubMed/29567782" } ] }, { "annotation": "Results found that XPO7 expression was significantly downregulated in the presence of the KLF1 Nan variant erythroid progenitors, potentially contributing to increased nuclear size. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_075532", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075532" }, { "database": "PubMed", "id": "30921348", "url": "https://glygen.org/publication/PubMed/30921348" } ] }, { "annotation": "Xpo7 negatively regulates Hedgehog signaling by exporting Gli2 from the nucleus.", "evidence": [ { "database": "RefSeq", "id": "NP_075532", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075532" }, { "database": "PubMed", "id": "33383157", "url": "https://glygen.org/publication/PubMed/33383157" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q9EPK7", "url": "https://www.uniprot.org/uniprot/Q9EPK7" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Xpo7", "url": "https://www.uniprot.org/uniprot/Q9EPK7", "locus": { "chromosome": "14", "start_pos": 70891686, "end_pos": 71004068, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000022100", "url": "https://www.ensembl.org/id/ENSMUSG00000022100" } ] } } ], "crossref": [ { "id": "ENSMUSG00000022100", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000022100", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "65246", "url": "https://www.ncbi.nlm.nih.gov/gene/65246", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q9EPK7", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q9EPK7*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001494", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001494", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011989", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016024", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR044189", "url": "https://www.ebi.ac.uk/interpro/entry/IPR044189", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:65246", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:65246", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1929705", "url": "http://www.informatics.jax.org/marker/MGI:1929705", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "Q9EPK7", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9EPK7", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "ANYHEFC", "url": "https://omabrowser.org/oma/group/ANYHEFC/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "118714at2759", "url": "http://www.orthodb.org/?query=118714at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12596", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12596", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12596:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12596:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03810", "url": "http://pfam.xfam.org/family/PF03810", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q9EPK7", "url": "http://purl.obolibrary.org/obo/PR_Q9EPK7", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_075532", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075532", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A2I3BQV5", "url": "https://www.uniprot.org/uniprot/A0A2I3BQV5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A2I3BQV5-1", "url": "https://www.uniprot.org/uniprot/A0A2I3BQV5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9PUW7", "url": "https://www.uniprot.org/uniprot/E9PUW7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9PUW7-1", "url": "https://www.uniprot.org/uniprot/E9PUW7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9EPK7", "url": "https://www.uniprot.org/uniprot/Q9EPK7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9EPK7-1", "url": "https://www.uniprot.org/uniprot/Q9EPK7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9EPK7-2", "url": "https://www.uniprot.org/uniprot/Q9EPK7-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADHVQSLAQLENLCKQLYETTDTTTRLQAEKALVEFTNSPDCLSKCQLLLERGSSSYSQLLAATCLTKLVSRTNNPLPLEQRIDIRNYVLNYLATRPKLATFVTQALIQLYARITKLGWFDCQKDDYVFRNAITDVTRFLQDSVEYCIIGVTILSQLTNEINQADTTHPLTKHRKIASSFRDSSLFDIFTLSCNLLKQASGKNLNLNDESQHGLLMQLLKLTHNCLNFDFIGTSTDESSDDLCTVQIPTSWRSAFLDSSTLQLFFDLYHSIPPSFSPLVLSCLVQIASVRRSLFNNAERAKFLSHLVDGVKRILENPQSLSDPNNYHEFCRLLARLKSNYQLGELVKVENYPDVIRLIANFTVTSLQHWEFAPNSVHYLLSLWQRLAASVPYVKATEPHMLETYTPEVTKAYITSRLESVHIILRDGLEDPLEDTGLVQQQLDQLSTIGRCEYEKTCALLVQLFDQSAQSYQELLQSASASPMDIAVQEGRLTWLVYIIGAVIGGRVSFASTDEQDAMDGELVCRVLQLMNLTDSRLAQAGNEKLELAMLSFFEQFRKIYIGDQVQKSSKLYRRLSEVLGLNDETMVLSVFIGKVITNLKYWGRCEPITSKTLQLLNDLSIGYSSVRKLVKLSAVQFMLNNHTSEHFSFLGINNQSNLTDMRCRTTFYTALGRLLMVDLGEDEDQYEQFMLPLTAAFEAVAQMFSTNSFNEQEAKRTLVGLVRDLRGIAFAFNAKTSFMMLFEWIYPSYMPILQRAIELWYHDPACTTPVLKLMAELVHNRSQRLQFDVSSPNGILLFRETSKMITMYGNRILTLGEVPKDQVYALKLKGISICFSMLKAALSGSYVNFGVFRLYGDDALENALQTFIKLLLSIPHSDLLDYPKLSQSYYSLLEVLTQDHMNFIASLEPHVIMYILSSISEGLTALDTMVCTGCCSCLDHIVTYLFKQLSRSTKKRTTPLNRESDCFLHIMQQHPAMIQQMLSTVLNIIIFEDCRNQWSMSRPLLGLILLNEKYFSDLRNSIVNSQPPEKQQAMHLCFENLMEGIERNLLTKNRDRFTQNLSAFRREVNDSMKNSTYGVNSNDMMS", "length": 1087, "header": "sp|Q9EPK7-1|XPO7_MOUSE Isoform 1 of Exportin-7 OS=Mus musculus OX=10090 GN=Xpo7 PE=1 SV=3 CANONICAL=Q9EPK7-1" }, "isoforms": [ { "isoform_ac": "A0A2I3BQV5-1", "url": "", "sequence": { "sequence": "MRDSGRKSLAQLENLCKQLYETTDTTTRLQAEKALVEFTNSPDCLSKCQLLLERGSSSYSQLLAATCLTKLVSRTNNPLPLEQRIDIRNYVLNYLATRPKLATFVTQALIQLYARITKLGWFDCQKDDYVFRNAITDVTRFLQDSVEYCIIGVTILSQLTNEINQADTTHPLTKHRKIASSFRDSSLFDIFTLSCNLLKQASGKNLNLNDESQHGLLMQLLKLTHNCLNFDFIGTSTDESSDDLCTVQIPTSWRSAFLDSSTLQLFFDLYHSIPPSFSPLVLSCLVQIASVRRSLFNNAERAKFLSHLVDGVKRILENPQSLSDPNNYHEFCRLLARLKSNYQLGELVKVENYPDVIRLIANFTVTSLQHWEFAPNSVHYLLSLWQRLAASVPYVKATEPHMLETYTPEVTKAYITSRLESVHIILRDGLEDPLEDTGLVQQQLDQLSTIGRCEYEKTCALLVQLFDQSAQSYQELLQSASASPMDIAVQEGRLTWLVYIIGAVIGGRVSFASTDEQDAMDGELVCRVLQLMNLTDSRLAQAGNEKLELAMLSFFEQFRKIYIGDQVQKSSKLYRRLSEVLGLNDETMVLSVFIGKVITNLKYWGRCEPITSKTLQLLNDLSIGYSSVRKLVKLSAVQFMLNNHTSEHFSFLGINNQSNLTDMRCRTTFYTALGRLLMVDLGEDEDQYEQFMLPLTAAFEAVAQMFSTNSFNEQEAKRTLVGLVRDLRGIAFAFNAKTSFMMLFEWIYPSYMPILQRAIELWYHDPACTTPVLKLMAELVHNRSQRLQFDVSSPNGILLFRETSKMITMYGNRILTLGEVPKDQVYALKLKGISICFSMLKAALSGSYVNFGVFRLYGDDALENALQTFIKLLLSIPHSDLLDYPKLSQSYYSLLEVLTQDHMNFIASLEPHVIMYILSSISEGLTALDTMVCTGCCSCLDHIVTYLFKQLSRSTKKRTTPLNRESDCFLHIMQQHPAMIQQMLSTVLNIIIFEDCRNQWSMSRPLLGLILLNEKYFSDLRNSIVNSQPPEKQQAMHLCFENLMEGIERNLLTKNRDRFTQNLSAFRREVNDSMKNSTYGVNSNDMMS", "length": 1088, "header": "tr|A0A2I3BQV5-1|A0A2I3BQV5_MOUSE Computationally mapped isoform of Exportin 7 OS=Mus musculus OX=10090 GN=Xpo7 PE=1 SV=1 CANONICAL=Q9EPK7-1" }, "locus": { "chromosome": "14", "start_pos": 70945411, "end_pos": 70903444, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000228346.2", "url": "https://www.ensembl.org/id/ENSMUST00000228346.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000154350.2", "url": "https://www.ensembl.org/id/ENSMUSP00000154350.2" } ] } }, { "isoform_ac": "E9PUW7-1", "url": "", "sequence": { "sequence": "MADHVQSLAQLENLCKQLYETTDTTTRLQAEKALVEFTNSPDCLSKCQLLLERGSSSYSQLLAATCLTKLVSRTNNPLPLEQRIDIRNYVLNYLATRPKLATFVTQALIQLYARITKLGWFDCQKDDYVFRNAITDVTRFLQDSVEYCIIGVTILSQLTNEINQADTTHPLTKHRKIASSFRDSSLFDIFTLSCNLLKQASGKNLNLNDESQHGLLMQLLKLTHNCLNFDFIGTSTDESSDDLCTVQIPTSWRSAFLDSSTLQLFFDLYHSIPPSFSPLVLSCLVQIASVRRSLFNNAERAKFLSHLVDGVKRILENPQSLSDPNNYHEFCRLLARLKSNYQLGELVKVENYPDVIRLIANFTVTSLQHWEFAPNSVHYLLSLWQRLAASVPYVKATEPHMLETYTPEVTKAYITSRLESVHIILSRDGLEDPLEDTGLVQQQLDQLSTIGRCEYEKTCALLVQLFDQSAQSYQELLQSASASPMDIAVQEGRLTWLVYIIGAVIGGRVSFASTDEQDAMDGELVCRVLQLMNLTDSRLAQAGNEKLELAMLSFFEQFRKIYIGDQVQKSSKLYRRLSEVLGLNDETMVLSVFIGKVITNLKYWGRCEPITSKTLQLLNDLSIGYSSVRKLVKLSAVQFMLNNHTSEHFSFLGINNQSNLTDMRCRTTFYTALGRLLMVDLGEDEDQYEQFMLPLTAAFEAVAQMFSTNSFNEQEAKRTLVGLVRDLRGIAFAFNAKTSFMMLFEWIYPSYMPILQRAIELWYHDPACTTPVLKLMAELVHNRSQRLQFDVSSPNGILLFRETSKMITMYGNRILTLGEVPKDQVYALKLKGISICFSMLKAALSGSYVNFGVFRLYGDDALENALQTFIKLLLSIPHSDLLDYPKLSQSYYSLLEVLTQDHMNFIASLEPHVIMYILSSISEGLTALDTMVCTGCCSCLDHIVTYLFKQLSRSTKKRTTPLNRESDCFLHIMQQHPAMIQQMLSTVLNIIIFEDCRNQWSMSRPLLGLILLNEKYFSDLRNSIVNSQPPEKQQAMHLCFENLMEGIERNLLTKNRDRFTQNLSAFRREVNDSMKNSTYGVNSNDMMS", "length": 1088, "header": "tr|E9PUW7-1|E9PUW7_MOUSE Computationally mapped isoform of Exportin 7 OS=Mus musculus OX=10090 GN=Xpo7 PE=1 SV=1 CANONICAL=Q9EPK7-1" }, "locus": { "chromosome": "14", "start_pos": 71003969, "end_pos": 70903444, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000167242.8", "url": "https://www.ensembl.org/id/ENSMUST00000167242.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000129504.2", "url": "https://www.ensembl.org/id/ENSMUSP00000129504.2" } ] } }, { "isoform_ac": "Q9EPK7-1", "url": "", "sequence": { "sequence": "MADHVQSLAQLENLCKQLYETTDTTTRLQAEKALVEFTNSPDCLSKCQLLLERGSSSYSQLLAATCLTKLVSRTNNPLPLEQRIDIRNYVLNYLATRPKLATFVTQALIQLYARITKLGWFDCQKDDYVFRNAITDVTRFLQDSVEYCIIGVTILSQLTNEINQADTTHPLTKHRKIASSFRDSSLFDIFTLSCNLLKQASGKNLNLNDESQHGLLMQLLKLTHNCLNFDFIGTSTDESSDDLCTVQIPTSWRSAFLDSSTLQLFFDLYHSIPPSFSPLVLSCLVQIASVRRSLFNNAERAKFLSHLVDGVKRILENPQSLSDPNNYHEFCRLLARLKSNYQLGELVKVENYPDVIRLIANFTVTSLQHWEFAPNSVHYLLSLWQRLAASVPYVKATEPHMLETYTPEVTKAYITSRLESVHIILRDGLEDPLEDTGLVQQQLDQLSTIGRCEYEKTCALLVQLFDQSAQSYQELLQSASASPMDIAVQEGRLTWLVYIIGAVIGGRVSFASTDEQDAMDGELVCRVLQLMNLTDSRLAQAGNEKLELAMLSFFEQFRKIYIGDQVQKSSKLYRRLSEVLGLNDETMVLSVFIGKVITNLKYWGRCEPITSKTLQLLNDLSIGYSSVRKLVKLSAVQFMLNNHTSEHFSFLGINNQSNLTDMRCRTTFYTALGRLLMVDLGEDEDQYEQFMLPLTAAFEAVAQMFSTNSFNEQEAKRTLVGLVRDLRGIAFAFNAKTSFMMLFEWIYPSYMPILQRAIELWYHDPACTTPVLKLMAELVHNRSQRLQFDVSSPNGILLFRETSKMITMYGNRILTLGEVPKDQVYALKLKGISICFSMLKAALSGSYVNFGVFRLYGDDALENALQTFIKLLLSIPHSDLLDYPKLSQSYYSLLEVLTQDHMNFIASLEPHVIMYILSSISEGLTALDTMVCTGCCSCLDHIVTYLFKQLSRSTKKRTTPLNRESDCFLHIMQQHPAMIQQMLSTVLNIIIFEDCRNQWSMSRPLLGLILLNEKYFSDLRNSIVNSQPPEKQQAMHLCFENLMEGIERNLLTKNRDRFTQNLSAFRREVNDSMKNSTYGVNSNDMMS", "length": 1087, "header": "sp|Q9EPK7-1|XPO7_MOUSE Isoform 1 of Exportin-7 OS=Mus musculus OX=10090 GN=Xpo7 PE=1 SV=3 CANONICAL=Q9EPK7-1" }, "locus": { "chromosome": "14", "start_pos": 71003969, "end_pos": 70903444, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000022696", "url": "https://www.ensembl.org/id/ENSMUST00000022696" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000022696", "url": "https://www.ensembl.org/id/ENSMUSP00000022696" } ] } }, { "isoform_ac": "Q9EPK7-2", "url": "", "sequence": { "sequence": "MADHVQSLAQLENLCKQLYETTDTTTRLQAEKALVEFTNSPDCLSKCQLLLERGSSSYSQLLAATCLTKLVSRTNNPLPLEQRIDIRNYVLNYLATRPKLATFVTQALIQLYARITKLGWFDCQKDDYVFRNAITDVTRFLQDSVEYCIIGVTILSQLTNEINQADTTHPLTKHRKIASSFRDSSLFDIFTLSCNLLKQASGKNLNLNDESQHGLLMQLLKLTHNCLNFDFIGTSTDESSDDLCTVQIPTSWRSAFLDSSTLQLFFDLYHSIPPSFSPLVLSCLVQIASVRRSLFNNAERAKFLSHLVDGVKRILENPQSLSDPNNYHEFCRLLARLKSNYQLGELVKVENYPDVIRLIANFTVTSLQHWEFAPNSVHYLLSLWQRLAASVPYVKATEPHMLETYTPEVTKAYITSRLESVHIILRDGLEDPLEDTGLVQQQLDQLSTIGRCEYEKTCALLVQLFDQSAQSYQELLQSASASPMDIAVQEGRLTWLVYIIGAVIGGRVSFASTDEQDAMDGELVCRVLQLMNLTDSRLAQAGNEKLELAMLSFFEQFRKIYIGDQVQKSSKLYRRLSEVLGLNDETMVLSVFIGKVITNLKYWGRCEPITSKTLQLLNDLSIGYSSVRKLVKLSAVQFMLNNHTSEHFSFLGINNQSNLTDMRCRTTFYTALGRLLMVDLGEDEDQYEQFMLPLTAAFEAVAQMFSTNSFNEQEAKRTLVGLVRDLRGIAFAFNAKTSFMMLFEWIYPSYMPILQRAIELWYHDPACTTPVLKLMAELVHNRSQRLQFDVSSPNGILLFRETSKMITMYGNRILTLGEVPKDQVYALKLKGISICFSMLKAALSGSYVNFGVFRLYGDDALENALQTFIKLLLSIPHSDLLDYPKLSQSYYSLLEVLTQDHMNFIASLEPHVIMYILSSISEGLTALDTMVCTGCCSCLDHIVTYLFKQLSRSTKKRTTPLNRESDCFLHIMQQHPAMIQQMLSTVLNIIIFEDCRNQWSMSRPLLGLILLNEKYFSDLRNSIVNSQPPEKQQAMHLCFENLMEGIERNLLTKNRDR", "length": 1057, "header": "sp|Q9EPK7-2|XPO7_MOUSE Isoform 2 of Exportin-7 OS=Mus musculus OX=10090 GN=Xpo7 PE=1 SV=3 CANONICAL=Q9EPK7-1" }, "locus": { "chromosome": "14", "start_pos": 71003969, "end_pos": 70904461, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000226448", "url": "https://www.ensembl.org/id/ENSMUST00000226448" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000153855", "url": "https://www.ensembl.org/id/ENSMUSP00000153855" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "Q9EPK7", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9EPK7" }, { "id": "33300544", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33300544" } ] } ], "phosphorylation": [ { "start_pos": 570, "end_pos": 570, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9EPK7", "url": "https://www.uniprot.org/uniprot/Q9EPK7" } ], "site_lbl": "Ser570" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Identification of a novel putative Ran-binding protein and its close homologue.", "journal": "Biochem. Biophys. Res. Commun.", "date": "2000", "authors": "Koch P, Bohlmann I, Schafer M, Hansen-Hagge TE, Kiyoi H, Wilda M, Hameister H, Bartram CR, Janssen JW", "evidence": [ { "database": "UniProtKB", "id": "Q9EPK7", "url": "https://www.uniprot.org/uniprot/Q9EPK7" } ], "reference": [ { "type": "PubMed", "id": "11071879", "url": "https://glygen.org/publication/PubMed/11071879" } ] }, { "title": "miR-181a regulates erythroid enucleation via the regulation of Xpo7 expression.", "journal": "Haematologica", "date": "2018", "authors": "Figueroa AA, Fasano JD, Martinez-Morilla S, Venkatesan S, Kupfer G, Hattangadi SM", "evidence": [ { "database": "RefSeq", "id": "NP_075532", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075532" } ], "reference": [ { "type": "PubMed", "id": "29567782", "url": "https://glygen.org/publication/PubMed/29567782" } ] }, { "title": "The mouse KLF1 Nan variant impairs nuclear condensation and erythroid maturation.", "journal": "PloS one", "date": "2019", "authors": "Cantu I, van de Werken HJG, Gillemans N, Stadhouders R, Heshusius S, Maas A, Esteghamat F, Ozgur Z, van IJcken WFJ, Grosveld F, von Lindern M, Philipsen S, van Dijk TB", "evidence": [ { "database": "RefSeq", "id": "NP_075532", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075532" } ], "reference": [ { "type": "PubMed", "id": "30921348", "url": "https://glygen.org/publication/PubMed/30921348" } ] }, { "title": "O-GlcNAcylation regulates dopamine neuron function, survival and degeneration in Parkinson disease.", "journal": "Brain : a journal of neurology", "date": "2020", "authors": "Lee BE, Kim HY, Kim HJ, Jeong H, Kim BG, Lee HE, Lee J, Kim HB, Lee SE, Yang YR, Yi EC, Hanover JA, Myung K, Suh PG, Kwon T, Kim JI", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9EPK7", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9EPK7" } ], "reference": [ { "type": "PubMed", "id": "33300544", "url": "https://glygen.org/publication/PubMed/33300544" } ] }, { "title": "Xpo7 negatively regulates Hedgehog signaling by exporting Gli2 from the nucleus.", "journal": "Cellular signalling", "date": "2021", "authors": "Markiewicz L, Uspienski T, Baran B, Niedziolka SM, Niewiadomski P", "evidence": [ { "database": "RefSeq", "id": "NP_075532", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075532" } ], "reference": [ { "type": "PubMed", "id": "33383157", "url": "https://glygen.org/publication/PubMed/33383157" } ] }, { "title": "An In Vivo Model for Elucidating the Role of an Erythroid-Specific Isoform of Nuclear Export Protein Exportin 7 (Xpo7) in Murine Erythropoiesis.", "journal": "Experimental hematology", "date": "2022", "authors": "Modepalli S, Martinez-Morilla S, Venkatesan S, Fasano J, Paulsen K, Gorlich D, Hattangadi S, Kupfer GM", "evidence": [ { "database": "RefSeq", "id": "NP_075532", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075532" } ], "reference": [ { "type": "PubMed", "id": "35973480", "url": "https://glygen.org/publication/PubMed/35973480" } ] }, { "title": "Exportin XPO7 acts as an oncogenic factor in prostate cancer via upregulation of TCF3.", "journal": "Journal of cancer research and clinical oncology", "date": "2023-08", "authors": "Lin Yu, Zhan Ming, Xu Bin", "evidence": [ { "database": "RefSeq", "id": "NP_075532", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075532" } ], "reference": [ { "type": "PubMed", "id": "37000263", "url": "https://glygen.org/publication/PubMed/37000263" } ] } ], "pathway": [ { "id": "mmu:65246", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:65246", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q9UIA9-1", "protein_name": "Exportin-7", "gene_name": "XPO7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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