The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "extracellular region, azurophil granule lumen", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3MIE4-1", "P09215-1", "P63086-1", "O35244-1", "P16638-1", "P50430-1", "P53534-1", "P46462-1", "D3ZZC1-1", "Q32KJ5-1", "D3ZUM4-1", "P06760-1", "P07824-1", "P30919-1", "P80067-1", "D3ZLZ7-1", "P00697-1", "P20070-1", "P20717-1", "Q6XQN1-1", "D4AE56-1", "P70709-1", "Q62662-1", "Q66H71-1", "Q6AYS4-1", "P00762-1", "P00763-1", "P17164-1", "Q62867-1", "Q9EPB1-1", "Q32KJ6-1", "Q6AXR4-1", "D3ZJF9-1" ], "evidence": [ { "id": "R-RNO-6798751", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-6798751" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "D3ZJF9", "gene_name": "Gla", "activity": [ { "ec_number": "3.2.1.-", "activity": "", "evidence": [ { "id": "D3ZJF9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZJF9" } ] } ] }, { "uniprot_ac": "D3ZLZ7", "gene_name": "Impdh1", "activity": [ { "ec_number": "1.1.1.205", "activity": "H2O + IMP + NAD(+) = H(+) + NADH + XMP.", "evidence": [ { "id": "D3ZLZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZLZ7" } ] }, { "ec_number": "1.1.1.205", "activity": "", "evidence": [ { "id": "D3ZLZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZLZ7" } ] } ] }, { "uniprot_ac": "D3ZUM4", "gene_name": "Glb1", "activity": [ { "ec_number": "3.2.1.23", "activity": "Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.", "evidence": [ { "id": "D3ZUM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZUM4" } ] }, { "ec_number": "3.2.1.23", "activity": "", "evidence": [ { "id": "D3ZUM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZUM4" } ] } ] }, { "uniprot_ac": "D3ZZC1", "gene_name": "Txndc5", "activity": [ { "ec_number": "5.3.4.1", "activity": "Catalyzes the rearrangement of -S-S- bonds in proteins.", "evidence": [ { "id": "D3ZZC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZZC1" } ] }, { "ec_number": "5.3.4.1", "activity": "", "evidence": [ { "id": "D3ZZC1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZZC1" } ] } ] }, { "uniprot_ac": "D4AE56", "gene_name": "Ptges2", "activity": [ { "ec_number": "5.3.99.3", "activity": "prostaglandin H2 = prostaglandin E2.", "evidence": [ { "id": "D4AE56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4AE56" } ] }, { "ec_number": "5.3.99.3", "activity": "", "evidence": [ { "id": "D4AE56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4AE56" } ] } ] }, { "uniprot_ac": "O35244", "gene_name": "Prdx6", "activity": [ { "ec_number": "1.11.1.27", "activity": "a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O.", "evidence": [ { "id": "O35244", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35244" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "O35244", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35244" } ] }, { "ec_number": "2.3.1.23", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA.", "evidence": [ { "id": "O35244", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35244" } ] }, { "ec_number": "1.11.1.27", "activity": "", "evidence": [ { "id": "O35244", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35244" } ] } ] }, { "uniprot_ac": "P00697", "gene_name": "Lyz1", "activity": [ { "ec_number": "3.2.1.17", "activity": "Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.", "evidence": [ { "id": "P00697", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00697" } ] }, { "ec_number": "3.2.1.17", "activity": "", "evidence": [ { "id": "P00697", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00697" } ] } ] }, { "uniprot_ac": "P00762", "gene_name": "Prss1", "activity": [ { "ec_number": "3.4.21.4", "activity": "Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.", "evidence": [ { "id": "P00762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00762" } ] }, { "ec_number": "3.4.21.4", "activity": "", "evidence": [ { "id": "P00762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00762" } ] } ] }, { "uniprot_ac": "P00763", "gene_name": "Prss2", "activity": [ { "ec_number": "3.4.21.4", "activity": "Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.", "evidence": [ { "id": "P00763", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00763" } ] }, { "ec_number": "3.4.21.4", "activity": "", "evidence": [ { "id": "P00763", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00763" } ] } ] }, { "uniprot_ac": "P06760", "gene_name": "Gusb", "activity": [ { "ec_number": "3.2.1.31", "activity": "a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate.", "evidence": [ { "id": "P06760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06760" } ] }, { "ec_number": "3.2.1.31", "activity": "", "evidence": [ { "id": "P06760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06760" } ] } ] }, { "uniprot_ac": "P07824", "gene_name": "Arg1", "activity": [ { "ec_number": "3.5.3.1", "activity": "H2O + L-arginine = L-ornithine + urea.", "evidence": [ { "id": "P07824", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07824" } ] }, { "ec_number": "3.5.3.1", "activity": "", "evidence": [ { "id": "P07824", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07824" } ] } ] }, { "uniprot_ac": "P09215", "gene_name": "Prkcd", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P09215", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09215" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P09215", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09215" } ] } ] }, { "uniprot_ac": "P16638", "gene_name": "Acly", "activity": [ { "ec_number": "2.3.3.8", "activity": "acetyl-CoA + ADP + oxaloacetate + phosphate = ATP + citrate + CoA.", "evidence": [ { "id": "P16638", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16638" } ] }, { "ec_number": "2.3.3.8", "activity": "", "evidence": [ { "id": "P16638", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16638" } ] } ] }, { "uniprot_ac": "P17164", "gene_name": "Fuca1", "activity": [ { "ec_number": "3.2.1.51", "activity": "an alpha-L-fucoside + H2O = an alcohol + L-fucose.", "evidence": [ { "id": "P17164", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17164" } ] }, { "ec_number": "3.2.1.51", "activity": "", "evidence": [ { "id": "P17164", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17164" } ] } ] }, { "uniprot_ac": "P20070", "gene_name": "Cyb5r3", "activity": [ { "ec_number": "1.6.2.2", "activity": "2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + H(+) + NAD(+).", "evidence": [ { "id": "P20070", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20070" } ] }, { "ec_number": "1.6.2.2", "activity": "", "evidence": [ { "id": "P20070", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20070" } ] } ] }, { "uniprot_ac": "P20717", "gene_name": "Padi2", "activity": [ { "ec_number": "3.5.3.15", "activity": "H2O + L-arginyl-[protein] = L-citrullyl-[protein] + NH4(+).", "evidence": [ { "id": "P20717", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20717" } ] }, { "ec_number": "3.5.3.15", "activity": "", "evidence": [ { "id": "P20717", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20717" } ] } ] }, { "uniprot_ac": "P30919", "gene_name": "Aga", "activity": [ { "ec_number": "3.5.1.26", "activity": "H2O + N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine = H(+) + L-aspartate + N-acetyl-beta-D-glucosaminylamine.", "evidence": [ { "id": "P30919", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30919" } ] }, { "ec_number": "3.5.1.26", "activity": "", "evidence": [ { "id": "P30919", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30919" } ] } ] }, { "uniprot_ac": "P46462", "gene_name": "Vcp", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P46462", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46462" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "P46462", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46462" } ] } ] }, { "uniprot_ac": "P50430", "gene_name": "Arsb", "activity": [ { "ec_number": "3.1.6.12", "activity": "Hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate.", "evidence": [ { "id": "P50430", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50430" } ] }, { "ec_number": "3.1.6.12", "activity": "", "evidence": [ { "id": "P50430", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50430" } ] } ] }, { "uniprot_ac": "P53534", "gene_name": "Pygb", "activity": [ { "ec_number": "2.4.1.1", "activity": "[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate.", "evidence": [ { "id": "P53534", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53534" } ] }, { "ec_number": "2.4.1.1", "activity": "", "evidence": [ { "id": "P53534", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53534" } ] } ] }, { "uniprot_ac": "P63086", "gene_name": "Mapk1", "activity": [ { "ec_number": "2.7.11.24", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P63086", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63086" } ] }, { "ec_number": "2.7.11.24", "activity": "", "evidence": [ { "id": "P63086", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63086" } ] } ] }, { "uniprot_ac": "P70709", "gene_name": "Rnase3", "activity": [ { "ec_number": "3.1.27.-", "activity": "", "evidence": [ { "id": "P70709", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70709" } ] } ] }, { "uniprot_ac": "P80067", "gene_name": "Ctsc", "activity": [ { "ec_number": "3.4.14.1", "activity": "Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, except when Xaa is Arg or Lys, or Yaa or Zaa is Pro.", "evidence": [ { "id": "P80067", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P80067" } ] }, { "ec_number": "3.4.14.1", "activity": "", "evidence": [ { "id": "P80067", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P80067" } ] } ] }, { "uniprot_ac": "Q32KJ5", "gene_name": "Gns", "activity": [ { "ec_number": "3.1.6.14", "activity": "Hydrolysis of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate.", "evidence": [ { "id": "Q32KJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q32KJ5" } ] }, { "ec_number": "3.1.6.14", "activity": "", "evidence": [ { "id": "Q32KJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q32KJ5" } ] } ] }, { "uniprot_ac": "Q32KJ6", "gene_name": "Galns", "activity": [ { "ec_number": "3.1.6.4", "activity": "Hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate.", "evidence": [ { "id": "Q32KJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q32KJ6" } ] }, { "ec_number": "3.1.6.4", "activity": "", "evidence": [ { "id": "Q32KJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q32KJ6" } ] } ] }, { "uniprot_ac": "Q3MIE4", "gene_name": "Vat1", "activity": [ { "ec_number": "1.-.-.-", "activity": "", "evidence": [ { "id": "Q3MIE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3MIE4" } ] } ] }, { "uniprot_ac": "Q62662", "gene_name": "Frk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q62662", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62662" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q62662", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62662" } ] } ] }, { "uniprot_ac": "Q62867", "gene_name": "Ggh", "activity": [ { "ec_number": "3.4.19.9", "activity": "(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + (n-1) H2O = (6S)-5,6,7,8-tetrahydrofolate + (n-1) L-glutamate.", "evidence": [ { "id": "Q62867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62867" } ] }, { "ec_number": "3.4.19.9", "activity": "", "evidence": [ { "id": "Q62867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62867" } ] } ] }, { "uniprot_ac": "Q66H71", "gene_name": "Cpped1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q66H71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q66H71" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q66H71", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q66H71" } ] } ] }, { "uniprot_ac": "Q6AXR4", "gene_name": "Hexb", "activity": [ { "ec_number": "3.2.1.52", "activity": "Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.", "evidence": [ { "id": "Q6AXR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AXR4" } ] }, { "ec_number": "3.2.1.52", "activity": "", "evidence": [ { "id": "Q6AXR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AXR4" } ] } ] }, { "uniprot_ac": "Q6AYS4", "gene_name": "Fuca2", "activity": [ { "ec_number": "3.2.1.51", "activity": "an alpha-L-fucoside + H2O = an alcohol + L-fucose.", "evidence": [ { "id": "Q6AYS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AYS4" } ] }, { "ec_number": "3.2.1.51", "activity": "", "evidence": [ { "id": "Q6AYS4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AYS4" } ] } ] }, { "uniprot_ac": "Q6XQN1", "gene_name": "Naprt", "activity": [ { "ec_number": "6.3.4.21", "activity": "5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate.", "evidence": [ { "id": "Q6XQN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6XQN1" } ] }, { "ec_number": "6.3.4.21", "activity": "", "evidence": [ { "id": "Q6XQN1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6XQN1" } ] } ] }, { "uniprot_ac": "Q9EPB1", "gene_name": "Dpp7", "activity": [ { "ec_number": "3.4.14.2", "activity": "Release of an N-terminal dipeptide, Xaa-Yaa-|-, preferentially when Yaa is Ala or Pro. Substrates are oligopeptides, preferentially tripeptides.", "evidence": [ { "id": "Q9EPB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9EPB1" } ] }, { "ec_number": "3.4.14.2", "activity": "", "evidence": [ { "id": "Q9EPB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9EPB1" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 8 }, { "field": "total_sites", "count": 6 }, { "field": "n_linked_glycans", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 7 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 1 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 2 }, { "field": "n_linked_glycan_sites", "count": 1 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 5 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }