{ "uniprot_canonical_ac": "Q9EP78-1", "uniprot_ac": "Q9EP78", "uniprot_id": "CHST7_MOUSE", "mass": { "chemical_mass": 54767.0, "monoisotopic_mass": 54767.0 }, "refseq": { "ac": "NP_068361", "name": "carbohydrate sulfotransferase 7 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068361" }, "gene_names": [ { "name": "Chst7", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q9EP78", "id": "Q9EP78" }, { "name": "2600013M07Rik; C6ST-2; glcNAc6ST-4; Gn6st-4; GST5", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068361", "id": "NP_068361" }, { "name": "Chst7", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068361", "id": "NP_068361" }, { "name": "Gst5", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9EP78", "id": "Q9EP78" } ], "protein_names": [ { "name": "Carbohydrate sulfotransferase 7", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q9EP78" }, { "name": "2.8.2.-", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9EP78" }, { "name": "2.8.2.17", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9EP78" }, { "name": "C6ST-2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9EP78" }, { "name": "Chondroitin 6-sulfotransferase 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9EP78" }, { "name": "GST-5", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9EP78" }, { "name": "Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 5", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9EP78" }, { "name": "GlcNAc6ST-4", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9EP78" }, { "name": "Gn6st-4", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9EP78" }, { "name": "N-acetylglucosamine 6-O-sulfotransferase 4", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9EP78" }, { "name": "carbohydrate (N-acetylglucosamino) sulfotransferase 7; chondroitin 6-sulfotransferase 2; N-acetylglucosamine 6-O-sulfotransferase 1; galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 5; N-acetylglucosamine 6-O-sulfotransferase 4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068361", "id": "NP_068361" }, { "name": "carbohydrate sulfotransferase 7 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068361", "id": "NP_068361" }, { "name": "mC6ST-2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9EP78" } ], "function": [ { "annotation": "Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues. Preferentially acts on mannose-linked GlcNAc. Also able to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Also acts on core 2 mucin-type oligosaccharide and N-acetyllactosamine oligomer with a lower efficiency. Has weak or no activity toward keratan sulfate and oligosaccharides containing the Galbeta1-4GlcNAc. Catalyzes 6-O-sulfation of beta-benzyl GlcNAc but not alpha- or beta-benzyl GalNAc.", "evidence": [ { "database": "UniProtKB", "id": "Q9EP78", "url": "https://www.uniprot.org/uniprot/Q9EP78#function" }, { "database": "PubMed", "id": "10913333", "url": "https://glygen.org/publication/PubMed/10913333" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs3407676350", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs3407676350" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 407, "end_pos": 407, "sequence_org": "T", "sequence_mut": "A", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NMT->NMA).", "chr_id": "X", "chr_pos": "19927173", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T407", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs3389557547", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs3389557547" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 483, "end_pos": 483, "sequence_org": "A", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NWA->NWS).", "chr_id": "X", "chr_pos": "19927401", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "A483", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q9EP78", "url": "https://www.uniprot.org/uniprot/Q9EP78" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Chst7", "url": "https://www.uniprot.org/uniprot/Q9EP78", "locus": { "chromosome": "X", "start_pos": 19963760, "end_pos": 19925799, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000037347", "url": "https://www.ensembl.org/id/ENSMUSG00000037347" } ] } } ], "crossref": [ { "id": "ENSMUSG00000037347", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000037347", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "2.8.2.17", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.8.2.17&UniProtAcc=Q9EP78", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "60322", "url": "https://www.ncbi.nlm.nih.gov/gene/60322", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "GPDB0007489", "url": "https://acgg.asia/db/gpdb/symbol/GPDB0007489", "database": "GlycoProtDB", "categories": [ "Glycoproteomics" ] }, { "id": "IPR000863", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000863", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016469", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016469", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:60322", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:60322", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1891767", "url": "http://www.informatics.jax.org/marker/MGI:1891767", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "MNKVICS", "url": "https://omabrowser.org/oma/group/MNKVICS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "3031241at2759", "url": "http://www.orthodb.org/?query=3031241at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10704", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10704", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10704:SF5", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10704:SF5", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00685", "url": "http://pfam.xfam.org/family/PF00685", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q9EP78", "url": "http://purl.obolibrary.org/obo/PR_Q9EP78", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-2022870", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2022870", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_068361", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068361", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "11108", "url": "https://www.rhea-db.org/rhea/11108", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q9EP78", "url": "https://www.uniprot.org/uniprot/Q9EP78", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9EP78-1", "url": "https://www.uniprot.org/uniprot/Q9EP78-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKGRRRRRREYCKFTLLLALYTLLLLLVPSVLDSHSEQDKGRNCPGLQRSLGVWSLEAAAAGEREQGAEVRSLAEGNPDRSPGSPGNLSAVGEAVTQEKQHIYVHATWRTGSSFLGELFNQHPDVFYLYEPMWHLWQALYPGDAESLQGALRDMLRSLFRCDFSVLRLYAQPGDPGERAPDSANLTTAMLFRWRTNKVICSPPLCPAAPRARADVGLVEDKACESTCPPVSLRALEAECRKYPVVVIKDVRLLDLGVLVPLLRDPGLNLKVVQLFRDPRAVHNSRLKSRQGLLRESIQVLRTRQRGDHFHRVLLAHGVDARPGGQARALPSAPRADFFLTSALEVICEAWLRDLLFTRGAPAWLRRRYLRLRYEDLVWQPQAQLRRLLRFSGLRTLAALDAFAFNMTRGSAYGADRPFHLSARDAREAVHAWRERLSQEQVRQVETACAPAMRLLAYPRSGDERDRKTVREGETPLETKANWAV", "length": 484, "header": "sp|Q9EP78-1|CHST7_MOUSE Isoform 1 of Carbohydrate sulfotransferase 7 OS=Mus musculus OX=10090 GN=Chst7 PE=2 SV=1 CANONICAL=Q9EP78-1" }, "isoforms": [ { "isoform_ac": "Q9EP78-1", "url": "", "sequence": { "sequence": "MKGRRRRRREYCKFTLLLALYTLLLLLVPSVLDSHSEQDKGRNCPGLQRSLGVWSLEAAAAGEREQGAEVRSLAEGNPDRSPGSPGNLSAVGEAVTQEKQHIYVHATWRTGSSFLGELFNQHPDVFYLYEPMWHLWQALYPGDAESLQGALRDMLRSLFRCDFSVLRLYAQPGDPGERAPDSANLTTAMLFRWRTNKVICSPPLCPAAPRARADVGLVEDKACESTCPPVSLRALEAECRKYPVVVIKDVRLLDLGVLVPLLRDPGLNLKVVQLFRDPRAVHNSRLKSRQGLLRESIQVLRTRQRGDHFHRVLLAHGVDARPGGQARALPSAPRADFFLTSALEVICEAWLRDLLFTRGAPAWLRRRYLRLRYEDLVWQPQAQLRRLLRFSGLRTLAALDAFAFNMTRGSAYGADRPFHLSARDAREAVHAWRERLSQEQVRQVETACAPAMRLLAYPRSGDERDRKTVREGETPLETKANWAV", "length": 484, "header": "sp|Q9EP78-1|CHST7_MOUSE Isoform 1 of Carbohydrate sulfotransferase 7 OS=Mus musculus OX=10090 GN=Chst7 PE=2 SV=1 CANONICAL=Q9EP78-1" }, "locus": { "chromosome": "X", "start_pos": 19963760, "end_pos": 19963360, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000044138", "url": "https://www.ensembl.org/id/ENSMUST00000044138" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000043222", "url": "https://www.ensembl.org/id/ENSMUSP00000043222" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 184, "start_aa": "Asn", "end_pos": 184, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn184", "evidence": [ { "id": "Q9EP78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9EP78#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 405, "start_aa": "Asn", "end_pos": 405, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn405", "evidence": [ { "id": "Q9EP78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9EP78#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 87, "start_aa": "Asn", "end_pos": 87, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn87", "evidence": [ { "id": "Q9EP78", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9EP78#ptm_processing" } ] } ], "phosphorylation": [ { "start_pos": 460, "end_pos": 460, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9EP78", "url": "https://www.uniprot.org/uniprot/Q9EP78" } ], "site_lbl": "Ser460" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Diversity of N-acetylglucosamine-6-O-sulfotransferases: molecular cloning of a novel enzyme with different distribution and specificities.", "journal": "Biochem. Biophys. Res. Commun.", "date": "2000", "authors": "Muramatsu T., Kadomatsu K., Uchimura K., Yamakawa T., Fasakhany F., Kurosawa N., Matsukawa T.", "evidence": [ { "database": "UniProtKB", "id": "Q9EP78", "url": "https://www.uniprot.org/uniprot/Q9EP78" } ], "reference": [ { "type": "PubMed", "id": "10913333", "url": "https://glygen.org/publication/PubMed/10913333" } ] }, { "title": "Sulfation of N-acetylglucosamine by chondroitin 6-sulfotransferase 2 (GST-5).", "journal": "J. Biol. Chem.", "date": "2000", "authors": "Bhakta S, Bartes A, Bowman KG, Kao WM, Polsky I, Lee JK, Cook BN, Bruehl RE, Rosen SD, Bertozzi CR, Hemmerich S", "evidence": [ { "database": "UniProtKB", "id": "Q9EP78", "url": "https://www.uniprot.org/uniprot/Q9EP78" } ], "reference": [ { "type": "PubMed", "id": "10956661", "url": "https://glygen.org/publication/PubMed/10956661" } ] } ], "pathway": [ { "id": "mmu:60322", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:60322", "resource": "KEGG Pathway" }, { "id": "R-MMU-2022870", "name": "Chondroitin sulfate biosynthesis", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2022870", "resource": "Reactome", "description": "Chondroitin sulfate biosynthesis" } ], "orthologs": [ { "uniprot_canonical_ac": "Q6XQG8-1", "protein_name": "Carbohydrate sulfotransferase 7", "gene_name": "Chst7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MKGRRRRRREYCKFTLLLALYTLLLLLVPSVLDSGSEQDKGGRDCPGLQRSLGVWSLEAAAAGEREQGAEVRFQAEGNPDRSPRPQGNLSAIRESVTQEKQHIYVHATWRTGSSFLGELFNQHPDVFYLYEPMWHLWQALYPGNAESLQGALRDMLRSLFRCDFSVLRLYAQPGDPAERAPDSANLTTAMLFRWRTNKVICSPPLCPAAPRARADVGLVEDKACESTCPPVPLRALEAECRKYPVVVIKDVRLLDLGVLVPLLRDPGLNLKVVQLFRDPRAVHNSRLKSRHGLLRESIQVLRTRQRGDRFQRVLLAHGVGARPGGQSRALPSAPRADFFLTSALEVICEAWLRDLLFTRGAPTWLRRRYLRLRYEDLVWQPQVQLRRLLRFSGLRTLAALDAFAFNMTRGSAYGADRPFHLSARDAREAVHAWRERLSQEQVRQVEAACDPAMRLLAYPRSGDERDVKTVRKGETPLETNANWAT", "length": 485 }, "evidence": [ { "id": "45238601", "url": "http://www.informatics.jax.org/homology/45238601", "database": "MGI" }, { "id": "Q9EP78", "url": "https://omabrowser.org/oma/group/Q9EP78/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9NS84-1", "protein_name": "Carbohydrate sulfotransferase 7", "gene_name": "CHST7", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MKGRRRRRREYCKFALLLVLYTLVLLLVPSVLDGGRDGDKGAEHCPGLQRSLGVWSLEAAAAGEREQGAEARAAEEGGANQSPRFPSNLSGAVGEAVSREKQHIYVHATWRTGSSFLGELFNQHPDVFYLYEPMWHLWQALYPGDAESLQGALRDMLRSLFRCDFSVLRLYAPPGDPAARAPDTANLTTAALFRWRTNKVICSPPLCPGAPRARAEVGLVEDTACERSCPPVAIRALEAECRKYPVVVIKDVRLLDLGVLVPLLRDPGLNLKVVQLFRDPRAVHNSRLKSRQGLLRESIQVLRTRQRGDRFHRVLLAHGVGARPGGQSRALPAAPRADFFLTGALEVICEAWLRDLLFARGAPAWLRRRYLRLRYEDLVRQPRAQLRRLLRFSGLRALAALDAFALNMTRGAAYGADRPFHLSARDAREAVHAWRERLSREQVRQVEAACAPAMRLLAYPRSGEEGDAEQPREGETPLEMDADGAT", "length": 486 }, "evidence": [ { "id": "45238601", "url": "http://www.informatics.jax.org/homology/45238601", "database": "MGI" }, { "id": "Q9EP78", "url": "https://omabrowser.org/oma/group/Q9EP78/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "N-acetylglucosamine 6-O-sulfotransferase activity", "id": "GO:0001517", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001517", "evidence": [ { "database": "UniProtKB", "id": "Q9EP78", "url": "https://www.uniprot.org/uniprot/Q9EP78" } ], "pmid": "" }, { "name": "chondroitin 6-sulfotransferase activity", "id": "GO:0008459", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008459", "evidence": [ { "database": "UniProtKB", "id": "Q9EP78", "url": "https://www.uniprot.org/uniprot/Q9EP78" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "N-acetylglucosamine metabolic process", "id": "GO:0006044", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006044", "evidence": [ { "database": "UniProtKB", "id": "Q9EP78", "url": "https://www.uniprot.org/uniprot/Q9EP78" } ], "pmid": "" }, { "name": "carbohydrate metabolic process", "id": "GO:0005975", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005975", "evidence": [ { "database": "UniProtKB", "id": "Q9EP78", "url": "https://www.uniprot.org/uniprot/Q9EP78" } ], "pmid": "" }, { "name": "sulfur compound metabolic process", "id": "GO:0006790", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006790", "evidence": [ { "database": "UniProtKB", "id": "Q9EP78", "url": "https://www.uniprot.org/uniprot/Q9EP78" } ], "pmid": "" }, { "name": "chondroitin sulfate biosynthetic process", "id": "GO:0030206", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030206", "evidence": [ { "database": "UniProtKB", "id": "Q9EP78", "url": "https://www.uniprot.org/uniprot/Q9EP78" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "Q9EP78", "url": "https://www.uniprot.org/uniprot/Q9EP78" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "Q9EP78", "url": "https://www.uniprot.org/uniprot/Q9EP78" } ], "pmid": "" }, { "name": "trans-Golgi network", "id": "GO:0005802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005802", "evidence": [ { "database": "UniProtKB", "id": "Q9EP78", "url": "https://www.uniprot.org/uniprot/Q9EP78" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 184, "end_pos": 186, "annotation": "n_glycosylation_sequon" }, { "start_pos": 405, "end_pos": 407, "annotation": "n_glycosylation_sequon" }, { "start_pos": 87, "end_pos": 89, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "11108", "name": "", "equation": "n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate = n adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate + 2 H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q6XQG8-1", "Q9QZL2-1", "Q7LGC8-1", "Q9NS84-1", "Q9EP78-1", "O88199-1" ], "evidence": [ { "id": "11108", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/11108" } ] }, { "id": "R-MMU-2018682", "name": "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "Golgi lumen, Golgi membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9EP78-1", "O88199-1" ], "evidence": [ { "id": "R-MMU-2018682", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2018682" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "O88199", "gene_name": "Chst3", "activity": [ { "ec_number": "2.8.2.17", "activity": "n 3'-phosphoadenylyl sulfate + chondroitin beta-D-glucuronate = n adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate + 2 H(+).", "evidence": [ { "id": "O88199", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88199" } ] }, { "ec_number": "2.8.2.21", "activity": "3'-phosphoadenylyl sulfate + keratan = adenosine 3',5'-bisphosphate + keratan 6'-sulfate.", "evidence": [ { "id": "O88199", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88199" } ] 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