{
    "uniprot_canonical_ac": "Q9D8T4-1",
    "uniprot_ac": "Q9D8T4",
    "uniprot_id": "TV23B_MOUSE",
    "mass": {
        "chemical_mass": 23305.0,
        "monoisotopic_mass": 23305.0
    },
    "refseq": {
        "ac": "NP_080486",
        "name": "Golgi apparatus membrane protein TVP23 homolog B isoform 1",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080486"
    },
    "gene_names": [
        {
            "name": "Tvp23b",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q9D8T4",
            "id": "Q9D8T4"
        },
        {
            "name": "1810036I24Rik; Fam18b; Fam18b1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080486",
            "id": "NP_080486"
        },
        {
            "name": "Fam18b1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q9D8T4",
            "id": "Q9D8T4"
        },
        {
            "name": "Fam18b",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q9D8T4",
            "id": "Q9D8T4"
        },
        {
            "name": "Tvp23b",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080486",
            "id": "NP_080486"
        }
    ],
    "protein_names": [
        {
            "name": "Golgi apparatus membrane protein TVP23 homolog B",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q9D8T4"
        },
        {
            "name": "Golgi apparatus membrane protein TVP23 homolog B isoform 1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080486",
            "id": "NP_080486"
        },
        {
            "name": "ortholog of human family with sequence similarity 18 member B FAM18B; protein FAM18B1; family with sequence similarity 18, member B; Golgi apparatus membrane protein TVP23 homolog B",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080486",
            "id": "NP_080486"
        }
    ],
    "function": [
        {
            "annotation": "Trans-Golgi protein TVP23B regulates host-microbe interactions via Paneth cell homeostasis and Goblet cell glycosylation. Publication Status: Online-Only",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_080486",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080486"
                },
                {
                    "database": "PubMed",
                    "id": "37339972",
                    "url": "https://glygen.org/publication/PubMed/37339972"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9D8T4",
                    "url": "https://www.uniprot.org/uniprot/Q9D8T4"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Tvp23b",
            "url": "https://www.uniprot.org/uniprot/Q9D8T4",
            "locus": {
                "chromosome": "11",
                "start_pos": 62807606,
                "end_pos": 62770281,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000014177",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000014177"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000014177",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000014177",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "67510",
            "url": "https://www.ncbi.nlm.nih.gov/gene/67510",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR008564",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR008564",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:67510",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:67510",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "1914760",
            "url": "http://www.informatics.jax.org/marker/MGI:1914760",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "DGNNHWK",
            "url": "https://omabrowser.org/oma/group/DGNNHWK/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "276475at2759",
            "url": "http://www.orthodb.org/?query=276475at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR13019",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13019",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR13019:SF9",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13019:SF9",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF05832",
            "url": "http://pfam.xfam.org/family/PF05832",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q9D8T4",
            "url": "http://purl.obolibrary.org/obo/PR_Q9D8T4",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_080486",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080486",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q9D8T4",
            "url": "https://www.uniprot.org/uniprot/Q9D8T4",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q9D8T4-1",
            "url": "https://www.uniprot.org/uniprot/Q9D8T4-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MLSQDSNDDTEDVSLFDAEEETTNRPRKSKIRHPVASFFHLFFRVSAVVVYLLCELLSSSFIACMVTIILLLSCDFWAVKNVTGRLMVGLRWWNHIDEDGKSHWVFESRKSTPQDNKTISEAESRIFWLGLIACPVLWVIFAFSALFSFRVKWLAVVIMGVVLQGANLYGYIRCKVGSKKNLTSMATSYLGKQFLRQNTGDGQTS",
        "length": 205,
        "header": "sp|Q9D8T4-1|TV23B_MOUSE Isoform 1 of Golgi apparatus membrane protein TVP23 homolog B  OS=Mus musculus OX=10090 GN=Tvp23b PE=1 SV=1 CANONICAL=Q9D8T4-1"
    },
    "isoforms": [
        {
            "isoform_ac": "Q9D8T4-1",
            "url": "",
            "sequence": {
                "sequence": "MLSQDSNDDTEDVSLFDAEEETTNRPRKSKIRHPVASFFHLFFRVSAVVVYLLCELLSSSFIACMVTIILLLSCDFWAVKNVTGRLMVGLRWWNHIDEDGKSHWVFESRKSTPQDNKTISEAESRIFWLGLIACPVLWVIFAFSALFSFRVKWLAVVIMGVVLQGANLYGYIRCKVGSKKNLTSMATSYLGKQFLRQNTGDGQTS",
                "length": 205,
                "header": "sp|Q9D8T4-1|TV23B_MOUSE Isoform 1 of Golgi apparatus membrane protein TVP23 homolog B  OS=Mus musculus OX=10090 GN=Tvp23b PE=1 SV=1 CANONICAL=Q9D8T4-1"
            },
            "locus": {
                "chromosome": "11",
                "start_pos": 62784971,
                "end_pos": 62770410,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000014321",
                        "url": "https://www.ensembl.org/id/ENSMUST00000014321"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000014321",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000014321"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 6,
            "end_pos": 6,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "",
            "evidence": [
                {
                    "database": "phospho.ELM",
                    "id": "Q9D8T4",
                    "url": "http://phospho.elm.eu.org/byAccession/Q9D8T4.html"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q9D8T4",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9D8T4"
                },
                {
                    "database": "PubMed",
                    "id": "17242355",
                    "url": "https://glygen.org/publication/PubMed/17242355"
                }
            ],
            "site_lbl": "Ser6"
        }
    ],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Large-scale phosphorylation analysis of mouse liver.",
            "journal": "Proc. Natl. Acad. Sci. U.S.A.",
            "date": "2007",
            "authors": "Villen J, Beausoleil SA, Gerber SA, Gygi SP",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9D8T4",
                    "url": "https://www.uniprot.org/uniprot/Q9D8T4"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q9D8T4",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9D8T4"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "17242355",
                    "url": "https://glygen.org/publication/PubMed/17242355"
                }
            ]
        },
        {
            "title": "Trans-Golgi protein TVP23B regulates host-microbe interactions via Paneth cell homeostasis and Goblet cell glycosylation.",
            "journal": "Nature communications",
            "date": "2023-06-20",
            "authors": "Song Ran, McAlpine William, Fond Aaron M, Nair-Gill Evan, Choi Jin Huk, Nystr\u00f6m Elisabeth E L, Arike Liisa, Field Sydney, Li Xiaohong, SoRelle Jeffrey A, Moresco James J, Moresco Eva Marie Y, Yates John R, Azadi Parastoo, Ni Josephine, Birchenough George M H, Beutler Bruce, Turer Emre E",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_080486",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080486"
                }
            ],
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                {
                    "type": "PubMed",
                    "id": "37339972",
                    "url": "https://glygen.org/publication/PubMed/37339972"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:67510",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:67510",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "M0R766-1",
            "protein_name": "Golgi apparatus membrane protein TVP23 homolog",
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            "tax_id": 10116,
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                "length": 205
            },
            "evidence": [
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                    "id": "45233783",
                    "url": "http://www.informatics.jax.org/homology/45233783",
                    "database": "MGI"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "P38962-1",
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            "tax_id": 559292,
            "organism": "Saccharomyces cerevisiae S288C",
            "sequence": {
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                "length": 199
            },
            "evidence": [
                {
                    "id": "Q9D8T4",
                    "url": "https://omabrowser.org/oma/group/Q9D8T4/",
                    "database": "OMA"
                }
            ],
            "common_name": "Yeast"
        },
        {
            "uniprot_canonical_ac": "Q8IQC1-1",
            "protein_name": "Uncharacterized Golgi apparatus membrane protein-like protein CG5021",
            "gene_name": "",
            "tax_id": 7227,
            "organism": "Drosophila melanogaster",
            "sequence": {
                "sequence": "MASATVRNVPLLDDDTIPFGEEDEMRDPSRAGQKYTHPYVTFFHLFFRGAAILIYMFCGWFSDSFITSFVFVVLFLSADFWTVKNISGRLLVGLRWWNYVDDDGVSHWVFESKNSESYQSRVNKNEQRIFWLGLILCPVFWGLFFLFALFGLKFKWLLLVMIAIALNAANLYGYVKCNYGANKDLNSAATDFVKTQFFKNAVDIMTRPSGAPPPTNVRPTGVV",
                "length": 223
            },
            "evidence": [
                {
                    "id": "Q9D8T4",
                    "url": "https://omabrowser.org/oma/group/Q9D8T4/",
                    "database": "OMA"
                }
            ],
            "common_name": "Fruit fly"
        },
        {
            "uniprot_canonical_ac": "Q96ET8-1",
            "protein_name": "Golgi apparatus membrane protein TVP23 homolog C",
            "gene_name": "TVP23C",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MLQQDSNDDTEDVSLFDAEEETTNRPRKAKIRHPVASFFHLFFRVSAIIVCLLCELLSSSFITCMVTIILLLSCDFWAVKNVTGRLMVGLRWWNHIDEDGKSHWVFESRKESSQENKTVSEAESRIFWLGLIACSVLWVIFAFSALFSFTVKWLRRSRHIAQTGLKVLGSRDPPASAFQSAGITGVSRCPGHPSRKFHQVDINSFTRITDRALYWKPAPRLSSPPLRAAPGNCQQMAPARLFLSLRLWAWRGGGESPNSRGTGEPGPKFHLASGMH",
                "length": 276
            },
            "evidence": [
                {
                    "id": "45233783",
                    "url": "http://www.informatics.jax.org/homology/45233783",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9NYZ1-1",
            "protein_name": "Golgi apparatus membrane protein TVP23 homolog B",
            "gene_name": "TVP23B",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MLQQDSNDDTEDVSLFDAEEETTNRPRKAKIRHPVASFFHLFFRVSAIIVYLLCGLLSSSFITCMVTIILLLSCDFWAVKNVTGRLMVGLRWWNHIDEDGKSHWVFESRKESSQENKTVSEAESRIFWLGLIACPVLWVIFAFSALFSFRVKWLAVVIMGVVLQGANLYGYIRCKVRSRKHLTSMATSYFGKQFLRQNTGDDQTS",
                "length": 205
            },
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                {
                    "id": "Q9D8T4",
                    "url": "https://omabrowser.org/oma/group/Q9D8T4/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 1,
                "go_terms": [
                    {
                        "name": "membrane",
                        "id": "GO:0016020",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020",
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                                "database": "UniProtKB",
                                "id": "Q9D8T4",
                                "url": "https://www.uniprot.org/uniprot/Q9D8T4"
                            }
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                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
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                "go_terms": [
                    {
                        "name": "vesicle-mediated transport",
                        "id": "GO:0016192",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016192",
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                                "database": "UniProtKB",
                                "id": "Q9D8T4",
                                "url": "https://www.uniprot.org/uniprot/Q9D8T4"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein secretion",
                        "id": "GO:0009306",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009306",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9D8T4",
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                            }
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                ]
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        ]
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    "pro_annotation": [],
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        {
            "start_pos": 116,
            "end_pos": 118,
            "annotation": "n_glycosylation_sequon"
        },
        {
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            "end_pos": 183,
            "annotation": "n_glycosylation_sequon"
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            "start_pos": 81,
            "end_pos": 83,
            "annotation": "n_glycosylation_sequon"
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    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        },
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        }
    ],
    "section_stats": [
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