{
    "uniprot_canonical_ac": "Q9D7F2-2",
    "uniprot_ac": "Q9D7F2",
    "uniprot_id": "LPD6B_MOUSE",
    "mass": {
        "chemical_mass": 19528.0,
        "monoisotopic_mass": 19528.0
    },
    "refseq": {
        "ac": "NP_082266",
        "name": "ly6/PLAUR domain-containing protein 6B precursor",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082266"
    },
    "gene_names": [
        {
            "name": "Lypd6b",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q9D7F2",
            "id": "Q9D7F2"
        },
        {
            "name": "2310010M24Rik",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082266",
            "id": "NP_082266"
        },
        {
            "name": "Lypd6b",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082266",
            "id": "NP_082266"
        }
    ],
    "protein_names": [
        {
            "name": "Ly6/PLAUR domain-containing protein 6B",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q9D7F2"
        },
        {
            "name": "ly6/PLAUR domain-containing protein 6B precursor",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082266",
            "id": "NP_082266"
        },
        {
            "name": "ly6/PLAUR domain-containing protein 6B",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082266",
            "id": "NP_082266"
        }
    ],
    "function": [
        {
            "annotation": "Likely acts as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro acts on nAChRs in a subtype- and stoichiometry-dependent manner. Modulates specifically alpha-3(3):beta-4(2) nAChRs by enhancing the sensitivity to ACh, decreasing ACh-induced maximal current response and increasing the rate of desensitization to ACh; has no effect on alpha-7 homomeric nAChRs; modulates alpha-3(2):alpha-5:beta-4(2) nAChRs in the context of CHRNA5/alpha-5 variant Asn-398 but not its wild-type sequence. However, according to another report in vitro it can weakly inhibits alpha-7 nAChRs.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9D7F2",
                    "url": "https://www.uniprot.org/uniprot/Q9D7F2#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q8NI32",
                    "url": "https://www.uniprot.org/uniprot/Q8NI32#function"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9D7F2",
                    "url": "https://www.uniprot.org/uniprot/Q9D7F2"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Lypd6b",
            "url": "https://www.uniprot.org/uniprot/Q9D7F2",
            "locus": {
                "chromosome": "2",
                "start_pos": 49838861,
                "end_pos": 49677700,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000026765",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000026765"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000026765",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000026765",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "71897",
            "url": "https://www.ncbi.nlm.nih.gov/gene/71897",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR039457",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR039457",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR045860",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR045860",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:71897",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:71897",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "1919147",
            "url": "http://www.informatics.jax.org/marker/MGI:1919147",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "FVGCHRH",
            "url": "https://omabrowser.org/oma/group/FVGCHRH/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "4116921at2759",
            "url": "http://www.orthodb.org/?query=4116921at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR31171",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31171",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR31171:SF3",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31171:SF3",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF16975",
            "url": "http://pfam.xfam.org/family/PF16975",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q9D7F2",
            "url": "http://purl.obolibrary.org/obo/PR_Q9D7F2",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "R-MMU-163125",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-163125",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_082266",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082266",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q9D7F2",
            "url": "https://www.uniprot.org/uniprot/Q9D7F2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q9D7F2-1",
            "url": "https://www.uniprot.org/uniprot/Q9D7F2-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q9D7F2-2",
            "url": "https://www.uniprot.org/uniprot/Q9D7F2-2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MLLLCHILAVTILQILIISENWVFAKNINFYNVRPPLDPTPFPNSFKCFTCENAGDNYNCNRWAEDKWCPQDTQYCLTVHHFTSHGRSTSITKKCASKNECHFVGCRHSRDSEHTECRSCCEGMICNVELPTNHTNAVFAVMHAQRTSGSSVSSVPSPYLLVLAWLFMLPLL",
        "length": 172,
        "header": "sp|Q9D7F2-2|LPD6B_MOUSE Isoform 2 of Ly6/PLAUR domain-containing protein 6B  OS=Mus musculus OX=10090 GN=Lypd6b PE=2 SV=2 CANONICAL=Q9D7F2-2"
    },
    "isoforms": [
        {
            "isoform_ac": "Q9D7F2-1",
            "url": "",
            "sequence": {
                "sequence": "MCSSFQRHTTLTCPIRVDRMLLLCHILAVTILQILIISENWVFAKNINFYNVRPPLDPTPFPNSFKCFTCENAGDNYNCNRWAEDKWCPQDTQYCLTVHHFTSHGRSTSITKKCASKNECHFVGCRHSRDSEHTECRSCCEGMICNVELPTNHTNAVFAVMHAQRTSGSSVSSVPSPYLLVLAWLFMLPLL",
                "length": 191,
                "header": "sp|Q9D7F2-1|LPD6B_MOUSE Isoform 1 of Ly6/PLAUR domain-containing protein 6B  OS=Mus musculus OX=10090 GN=Lypd6b PE=2 SV=2 CANONICAL=Q9D7F2-2"
            },
            "locus": {}
        },
        {
            "isoform_ac": "Q9D7F2-2",
            "url": "",
            "sequence": {
                "sequence": "MLLLCHILAVTILQILIISENWVFAKNINFYNVRPPLDPTPFPNSFKCFTCENAGDNYNCNRWAEDKWCPQDTQYCLTVHHFTSHGRSTSITKKCASKNECHFVGCRHSRDSEHTECRSCCEGMICNVELPTNHTNAVFAVMHAQRTSGSSVSSVPSPYLLVLAWLFMLPLL",
                "length": 172,
                "header": "sp|Q9D7F2-2|LPD6B_MOUSE Isoform 2 of Ly6/PLAUR domain-containing protein 6B  OS=Mus musculus OX=10090 GN=Lypd6b PE=2 SV=2 CANONICAL=Q9D7F2-2"
            },
            "locus": {
                "chromosome": "2",
                "start_pos": 49837602,
                "end_pos": 49832494,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000028103",
                        "url": "https://www.ensembl.org/id/ENSMUST00000028103"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000028103",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000028103"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [],
    "pathway": [
        {
            "id": "mmu:71897",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:71897",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-MMU-163125",
            "name": "Post-translational modification: synthesis of GPI-anchored proteins",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-163125",
            "resource": "Reactome",
            "description": "Post-translational modification: synthesis of GPI-anchored proteins"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "D3ZUF1-1",
            "protein_name": "LY6/PLAUR domain containing 6B",
            "gene_name": "Lypd6b",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MECFSPRMPGNCCPTWSSFQRHTTLTCPVKEFRMLLLCHILAVTILQILVISENWVFAKNINFYNVRPPLDPTPFPNSFKCFTCENAGDNYNCNRWAEDKWCPQETQYCLTVHHFTSHGRSTSITKKCASKNECHFVGCRHSRDSEHTECRSCCEGMICNVELPTNHTNAVFAVMHAQRTSGSSVSNVPRSYLPVLAWLFMLPLL",
                "length": 205
            },
            "evidence": [
                {
                    "id": "45233777",
                    "url": "http://www.informatics.jax.org/homology/45233777",
                    "database": "MGI"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q8NI32-1",
            "protein_name": "Ly6/PLAUR domain-containing protein 6B",
            "gene_name": "LYPD6B",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MLYKSSDRPAHKVSMLLLCHALAIAVVQIVIFSESWAFAKNINFYNVRPPLDPTPFPNSFKCFTCENAGDNYNCNRWAEDKWCPQNTQYCLTVHHFTSHGRSTSITKKCASRSECHFVGCHHSRDSEHTECRSCCEGMICNVELPTNHTNAVFAVMHAQRTSGSSAPTLYLPVLAWVFVLPLL",
                "length": 183
            },
            "evidence": [
                {
                    "id": "45233777",
                    "url": "http://www.informatics.jax.org/homology/45233777",
                    "database": "MGI"
                },
                {
                    "id": "Q9D7F2",
                    "url": "https://omabrowser.org/oma/group/Q9D7F2/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 1,
                "go_terms": [
                    {
                        "name": "acetylcholine receptor regulator activity",
                        "id": "GO:0030548",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030548",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9D7F2",
                                "url": "https://www.uniprot.org/uniprot/Q9D7F2"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 2,
                "go_terms": [
                    {
                        "name": "plasma membrane",
                        "id": "GO:0005886",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9D7F2",
                                "url": "https://www.uniprot.org/uniprot/Q9D7F2"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "side of membrane",
                        "id": "GO:0098552",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098552",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9D7F2",
                                "url": "https://www.uniprot.org/uniprot/Q9D7F2"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 133,
            "end_pos": 135,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        },
        {
            "name": "homologset.oma",
            "label": "OMA Homologs"
        }
    ],
    "section_stats": [
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                    "field": "o_linked_glycan_sites",
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}