{ "uniprot_canonical_ac": "Q9D706-1", "uniprot_ac": "Q9D706", "uniprot_id": "RPAP3_MOUSE", "mass": { "chemical_mass": 74096.0, "monoisotopic_mass": 74096.0 }, "refseq": { "ac": "NP_082279", "name": "RNA polymerase II-associated protein 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082279" }, "gene_names": [ { "name": "Rpap3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q9D706", "id": "Q9D706" }, { "name": "2310042P20Rik; D15Ertd682e", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082279", "id": "NP_082279" }, { "name": "D15Ertd682e", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9D706", "id": "Q9D706" }, { "name": "Rpap3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082279", "id": "NP_082279" } ], "protein_names": [ { "name": "RNA polymerase II-associated protein 3", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q9D706" }, { "name": "RNA polymerase II-associated protein 3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082279", "id": "NP_082279" } ], "function": [ { "annotation": "Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation.", "evidence": [ { "database": "UniProtKB", "id": "Q9D706", "url": "https://www.uniprot.org/uniprot/Q9D706#function" }, { "database": "UniProtKB", "id": "Q9H6T3", "url": "https://www.uniprot.org/uniprot/Q9H6T3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q9D706", "url": "https://www.uniprot.org/uniprot/Q9D706" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Rpap3", "url": "https://www.uniprot.org/uniprot/Q9D706", "locus": { "chromosome": "15", "start_pos": 97572978, "end_pos": 97603706, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000022466", "url": "https://www.ensembl.org/id/ENSMUSG00000022466" } ] } } ], "crossref": [ { "id": "ENSMUSG00000022466", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000022466", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "71919", "url": "https://www.ncbi.nlm.nih.gov/gene/71919", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q9D706", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q9D706*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001440", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001440", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR025986", "url": "https://www.ebi.ac.uk/interpro/entry/IPR025986", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:71919", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:71919", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1277218", "url": "http://www.informatics.jax.org/marker/MGI:1277218", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "GTAQFHV", "url": "https://omabrowser.org/oma/group/GTAQFHV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2294768at2759", "url": "http://www.orthodb.org/?query=2294768at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46423", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46423", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46423:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46423:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00515", "url": "http://pfam.xfam.org/family/PF00515", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13176", "url": "http://pfam.xfam.org/family/PF13176", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13877", "url": "http://pfam.xfam.org/family/PF13877", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q9D706", "url": "http://purl.obolibrary.org/obo/PR_Q9D706", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_082279", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082279", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q9D706", "url": "https://www.uniprot.org/uniprot/Q9D706", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9D706-1", "url": "https://www.uniprot.org/uniprot/Q9D706-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTSASKAVELQLQVKHNAEELQDFMRDLEHWEKDMKEKDLELRRQGGVAEENLPPIRNGNFRKKKKKGKAKESSRKTKEENTKNRIKSYDYDAWAKLDVDRILDELDKEDSTHDSLSQESESDEDGIRVDSQKALVLKEKGNKYFKQGKYDEAIECYTKGMDADPYNPVLPTNRASAYFRLKKFAVAESDCNLAIALSRTYTKAYARRGAARFALQKLEDARKDYEKVLELEPDNFEATNELRKINQALTSKENSGPGAAAAAESKPAAGESKPTGGQQGRQKAIAEKDLGNGFFKEGKYEQAIECYTRGIAADRTNALLPANRAMAYLKIQRYEEAERDCTQAIVLDGSYSKAFARRGTARTFLGKINEAKQDFETVLLLEPGNKQAATELSRIKKELIEKGHWDDVFLDSTQRHHVVKAVDNPPRGSPKALKKVFIEETGNLIETVDAPDSSATVPESDRATAAVGTGTKKNPSEGVSLPAGDRPRAKVLKIEAVSDTSAPQAQVGVKQDARQPGSEKASVRAEQMPGQLAAAGLPPVPANSFQLESDFRQLRSSPEMLYQYVKNIEPSLYPKLFQKNLDPDVFNQIIKILHDFYIEREKPALIFEVLERLSQLRRFDMAVMFMSGPERKLTNVLFNHLEKSDLKEDSVEELKKRYGG", "length": 660, "header": "sp|Q9D706-1|RPAP3_MOUSE Isoform 1 of RNA polymerase II-associated protein 3 OS=Mus musculus OX=10090 GN=Rpap3 PE=1 SV=1 CANONICAL=Q9D706-1" }, "isoforms": [ { "isoform_ac": "Q9D706-1", "url": "", "sequence": { "sequence": "MTSASKAVELQLQVKHNAEELQDFMRDLEHWEKDMKEKDLELRRQGGVAEENLPPIRNGNFRKKKKKGKAKESSRKTKEENTKNRIKSYDYDAWAKLDVDRILDELDKEDSTHDSLSQESESDEDGIRVDSQKALVLKEKGNKYFKQGKYDEAIECYTKGMDADPYNPVLPTNRASAYFRLKKFAVAESDCNLAIALSRTYTKAYARRGAARFALQKLEDARKDYEKVLELEPDNFEATNELRKINQALTSKENSGPGAAAAAESKPAAGESKPTGGQQGRQKAIAEKDLGNGFFKEGKYEQAIECYTRGIAADRTNALLPANRAMAYLKIQRYEEAERDCTQAIVLDGSYSKAFARRGTARTFLGKINEAKQDFETVLLLEPGNKQAATELSRIKKELIEKGHWDDVFLDSTQRHHVVKAVDNPPRGSPKALKKVFIEETGNLIETVDAPDSSATVPESDRATAAVGTGTKKNPSEGVSLPAGDRPRAKVLKIEAVSDTSAPQAQVGVKQDARQPGSEKASVRAEQMPGQLAAAGLPPVPANSFQLESDFRQLRSSPEMLYQYVKNIEPSLYPKLFQKNLDPDVFNQIIKILHDFYIEREKPALIFEVLERLSQLRRFDMAVMFMSGPERKLTNVLFNHLEKSDLKEDSVEELKKRYGG", "length": 660, "header": "sp|Q9D706-1|RPAP3_MOUSE Isoform 1 of RNA polymerase II-associated protein 3 OS=Mus musculus OX=10090 GN=Rpap3 PE=1 SV=1 CANONICAL=Q9D706-1" }, "locus": { "chromosome": "15", "start_pos": 97601235, "end_pos": 97573178, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000023104", "url": "https://www.ensembl.org/id/ENSMUST00000023104" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000023104", "url": "https://www.ensembl.org/id/ENSMUSP00000023104" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 117, "end_pos": 117, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9D706", "url": "https://www.uniprot.org/uniprot/Q9D706" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "iPTMnet", "id": "Q9D706", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9D706" } ], "site_lbl": "Ser117" }, { "start_pos": 120, "end_pos": 120, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9D706", "url": "https://www.uniprot.org/uniprot/Q9D706" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" }, { "database": "iPTMnet", "id": "Q9D706", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9D706" } ], "site_lbl": "Ser120" }, { "start_pos": 122, "end_pos": 122, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9D706", "url": "https://www.uniprot.org/uniprot/Q9D706" }, { "database": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" }, { "database": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" }, { "database": "iPTMnet", "id": "Q9D706", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9D706" } ], "site_lbl": "Ser122" }, { "start_pos": 476, "end_pos": 476, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9D706", "url": "https://www.uniprot.org/uniprot/Q9D706" } ], "site_lbl": "Ser476" }, { "start_pos": 88, "end_pos": 88, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9D706", "url": "https://www.uniprot.org/uniprot/Q9D706" } ], "site_lbl": "Ser88" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Large-scale phosphorylation analysis of mouse liver.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2007", "authors": "Villen J, Beausoleil SA, Gerber SA, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "Q9D706", "url": "https://www.uniprot.org/uniprot/Q9D706" }, { "database": "iPTMnet", "id": "Q9D706", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9D706" } ], "reference": [ { "type": "PubMed", "id": "17242355", "url": "https://glygen.org/publication/PubMed/17242355" } ] }, { "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.", "journal": "Cell", "date": "2010", "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "Q9D706", "url": "https://www.uniprot.org/uniprot/Q9D706" }, { "database": "iPTMnet", "id": "Q9D706", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9D706" } ], "reference": [ { "type": "PubMed", "id": "21183079", "url": "https://glygen.org/publication/PubMed/21183079" } ] } ], "pathway": [ { "id": "mmu:71919", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:71919", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q68FQ7-1", "protein_name": "RNA polymerase II-associated protein 3", "gene_name": "Rpap3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTSTSKAVELQLQVKHNAEELQDFMRDLEHWEKTMRQKDLELRRQSGVPEENLPPIRNGSFRKKKKRKTKDSSKKTKEENTKNRIKSFDYDAWAKLDVDSILDELDKEDSTHDSVSQESESDEDGVRVDSQKALVLKEKGNKYFKQGKYDEAIECYTKGMDADPYNPVLPTNRASAYFRLKKFAVAESDCNLAIALSRSYTKAYARRGAARFALQKLEDARKDYVKVLELEPDNFEATNELRKIDQALTSKENSHPKDIAAVIKPAEGERKANEDQRGRQKAIAEKDLGNGFFKEGKYEQAIECYTRGIAADSTNALLPANRAMAYLKVQKYEEAERDCTQAILLDGSYSKAFARRGTARTFLGKINEAKQDFETVLLLEPGNKQAVTELSRIKKELIEKGRWDDVFLDSTQRHNVVKPVDSPHRGSPKALKKVFIEETGNLIESVDAPESSATVPESDRAAVAVDTGRKKDFSQGDSVSSGETPRAKVLKIEAVGDSSAPQAQVDVKQGVRQSVSEKTSVRVAQTPGQLAAVVLPPVPANSFQLESDFRQLRSSPEMLYQYVKKIEPSLYPKLFQKNLDPDVFNQIIKILHDFYVEREKPALIFEVLERLSQLRRFDMAVMFMSGTERELTKVLFNHLEKSELKEDSVEELKKRYGGG", "length": 659 }, "evidence": [ { "id": "45238930", "url": "http://www.informatics.jax.org/homology/45238930", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9H6T3-1", "protein_name": "RNA polymerase II-associated protein 3", "gene_name": "RPAP3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MTSANKAIELQLQVKQNAEELQDFMRDLENWEKDIKQKDMELRRQNGVPEENLPPIRNGNFRKKKKGKAKESSKKTREENTKNRIKSYDYEAWAKLDVDRILDELDKDDSTHESLSQESESEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTNRASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATNELRKISQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISEKDRGNGFFKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSYSKAFARRGTARTFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKELIEKGHWDDVFLDSTQRQNVVKPIDNPPHPGSTKPLKKVIIEETGNLIQTIDVPDSTTAAAPENNPINLANVIAATGTTSKKNSSQDDLFPTSDTPRAKVLKIEEVSDTSSLQPQASLKQDVCQSYSEKMPIEIEQKPAQFATTVLPPIPANSFQLESDFRQLKSSPDMLYQYLKQIEPSLYPKLFQKNLDPDVFNQIVKILHDFYIEKEKPLLIFEILQRLSELKRFDMAVMFMSETEKKIARALFNHIDKSGLKDSSVEELKKRYGG", "length": 665 }, "evidence": [ { "id": "45238930", "url": "http://www.informatics.jax.org/homology/45238930", "database": "MGI" }, { "id": "Q9D706", "url": "https://omabrowser.org/oma/group/Q9D706/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "R2TP complex", "id": "GO:0097255", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097255", "evidence": [ { "database": "UniProtKB", "id": "Q9D706", "url": "https://www.uniprot.org/uniprot/Q9D706" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q9D706", "url": "https://www.uniprot.org/uniprot/Q9D706" } ], "pmid": "" }, { "name": "protein folding chaperone complex", "id": "GO:0101031", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0101031", "evidence": [ { "database": "UniProtKB", "id": "Q9D706", "url": "https://www.uniprot.org/uniprot/Q9D706" } ], "pmid": "" }, { "name": "RPAP3/R2TP/prefoldin-like complex", "id": "GO:1990062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990062", "evidence": [ { "database": "UniProtKB", "id": "Q9D706", "url": "https://www.uniprot.org/uniprot/Q9D706" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }