{ "uniprot_canonical_ac": "Q9D2R0-1", "uniprot_ac": "Q9D2R0", "uniprot_id": "AACS_MOUSE", "mass": { "chemical_mass": 75200.0, "monoisotopic_mass": 75200.0 }, "refseq": { "ac": "NP_084486", "name": "acetoacetyl-CoA synthetase", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084486" }, "gene_names": [ { "name": "Aacs", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q9D2R0", "id": "Q9D2R0" }, { "name": "2210408B16Rik; SUR5", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084486", "id": "NP_084486" }, { "name": "Aacs", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084486", "id": "NP_084486" } ], "protein_names": [ { "name": "Acetoacetyl-CoA synthetase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q9D2R0" }, { "name": "6.2.1.16", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9D2R0" }, { "name": "acetoacetyl-CoA synthetase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084486", "id": "NP_084486" } ], "function": [ { "annotation": "AACS promoter activity was controlled mainly by C/EBPalpha during adipogenesis.", "evidence": [ { "database": "RefSeq", "id": "NP_084486", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084486" }, { "database": "PubMed", "id": "18514076", "url": "https://glygen.org/publication/PubMed/18514076" } ] }, { "annotation": "Acetoacetyl-CoA synthetase, a ketone body-utilizing enzyme, is controlled by SREBP-2 and affects serum cholesterol levels.", "evidence": [ { "database": "RefSeq", "id": "NP_084486", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084486" }, { "database": "PubMed", "id": "22985732", "url": "https://glygen.org/publication/PubMed/22985732" } ] }, { "annotation": "Cleavage of AACS by legumain is critical for the regulation of enzymatic activity and results in gain-of-function changes.", "evidence": [ { "database": "RefSeq", "id": "NP_084486", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084486" }, { "database": "PubMed", "id": "27129883", "url": "https://glygen.org/publication/PubMed/27129883" } ] }, { "annotation": "Converts acetoacetate to acetoacetyl-CoA in the cytosol (By similarity). Ketone body-utilizing enzyme, responsible for the synthesis of cholesterol and fatty acids (PubMed:22985732).", "evidence": [ { "database": "UniProtKB", "id": "Q9D2R0", "url": "https://www.uniprot.org/uniprot/Q9D2R0#function" }, { "database": "PubMed", "id": "22985732", "url": "https://glygen.org/publication/PubMed/22985732" }, { "database": "UniProtKB", "id": "Q9JMI1", "url": "https://www.uniprot.org/uniprot/Q9JMI1#function" } ] }, { "annotation": "Knockdown of AACS inhibits differentiation of 3T3-L1 adipocytes and suppresses expression of the adipocyte markers, peroxisome proliferator-activated receptor gama and CCAAT/enhancer binding protein alpha.", "evidence": [ { "database": "RefSeq", "id": "NP_084486", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084486" }, { "database": "PubMed", "id": "23123469", "url": "https://glygen.org/publication/PubMed/23123469" } ] }, { "annotation": "These results suggest that AACS is regulated by SREBP-2 and involves in the normal development of neurons.", "evidence": [ { "database": "RefSeq", "id": "NP_084486", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084486" }, { "database": "PubMed", "id": "23000407", "url": "https://glygen.org/publication/PubMed/23000407" } ] }, { "annotation": "These results suggest that Sp1 regulates gene expression of AACS in Neuro-2a cells and ketone body utilization affects the balance of histone acetylation.", "evidence": [ { "database": "RefSeq", "id": "NP_084486", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084486" }, { "database": "PubMed", "id": "29137983", "url": "https://glygen.org/publication/PubMed/29137983" } ] } ], "disease": [ { "disease_id": "DOID:9970", "recommended_name": { "id": "DOID:9970", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9970", "name": "obesity", "description": "An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness." }, "synonyms": [ { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "inherited obesity", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "genetic obesity", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "genetic obesity (disease)", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "leanness, inherited, autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "monogenic obesity", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, association with, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, early-onset, susceptibility to, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, late-onset, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, mild, early-onset, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, severe, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, severe, and type II diabetes, Autosomal recessive", "description": "" }, { "id": "MONDO:0019182", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "name": "obesity, susceptibility to, Autosomal recessive", "description": "" }, { "id": "MIM:601665", "resource": "MIM", "url": "https://www.omim.org/entry/601665", "name": "Obesity", "description": "Obesity" } ], "evidence": [ { "id": "9970", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9970" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q9D2R0", "url": "https://www.uniprot.org/uniprot/Q9D2R0" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Aacs", "url": "https://www.uniprot.org/uniprot/Q9D2R0", "locus": { "chromosome": "5", "start_pos": 125594474, "end_pos": 125552878, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000029482", "url": "https://www.ensembl.org/id/ENSMUSG00000029482" } ] } } ], "crossref": [ { "id": "ENSMUSG00000029482", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000029482", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "6.2.1.16", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=6.2.1.16&UniProtAcc=Q9D2R0", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "cd05943", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05943", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "78894", "url": "https://www.ncbi.nlm.nih.gov/gene/78894", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q9D2R0", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q9D2R0*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000873", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000873", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005914", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005914", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020845", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020845", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032387", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032387", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042099", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042099", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045851", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045851", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:78894", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:78894", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1926144", "url": "http://www.informatics.jax.org/marker/MGI:1926144", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "WYSSTGW", "url": "https://omabrowser.org/oma/group/WYSSTGW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "45466at2759", "url": "http://www.orthodb.org/?query=45466at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR42921", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42921", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR42921:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR42921:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00501", "url": "http://pfam.xfam.org/family/PF00501", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF16177", "url": "http://pfam.xfam.org/family/PF16177", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q9D2R0", "url": "http://purl.obolibrary.org/obo/PR_Q9D2R0", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-77111", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-77111", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_084486", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084486", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "16117", "url": "https://www.rhea-db.org/rhea/16117", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "Q9D2R0", "url": "https://www.uniprot.org/uniprot/Q9D2R0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9D2R0-1", "url": "https://www.uniprot.org/uniprot/Q9D2R0-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSKLARLEREEIMECQVMWEPDSKKDTQMDRFRAAVGTACGLALGNYNDLYHWSVRSYMDFWAEFWKFSGIVYSRMYDEVVDTSKGIADVPEWFRGSRLNYAENLLRHKENDRVALYVAREGREEIVKVTFEELRQQVALFAAAMRKMGVKKGDRVVGYLPNSAHAVEAMLAAASIGAIWSSTSPDFGVNGVLDRFSQIQPKLIFSVEAVVYNGKEHGHLEKLQRVVKGLPDLQRVVLIPYVLPREKIDISKIPNSVFLDDFLASGTGAQAPQLEFEQLPFSHPLFIMFSSGTTGAPKCMVHSAGGTLIQHLKEHMLHGNMTSSDILLYYTTVGWMMWNWMVSALATGASLVLYDGSPLVPTPNVLWDLVDRIGITILGTGAKWLSVLEEKDMKPVETHNLHTLHTILSTGSPLKAQSYEYVYRCIKSSVLLGSISGGTDIISCFMGQNSSIPVYKGEIQARNLGMAVEAWDEEGKAVWGASGELVCTKPIPCQPTHFWNDENGSKYRKAYFSKFPGVWAHGDYCRINPKTGGIIMLGRSDGTLNPNGVRFGSSEIYNIVEAFDEVEDSLCVPQYNRDGEERVVLFLKMASGHTFQPDLVKRIRDAIRLGLSARHVPSLILETRGIPYTLNGKKVEVAVKQVMAGRTVEHRGAFSNPETLDLYRDIPELQDF", "length": 672, "header": "sp|Q9D2R0-1|AACS_MOUSE Isoform 1 of Acetoacetyl-CoA synthetase OS=Mus musculus OX=10090 GN=Aacs PE=1 SV=1 CANONICAL=Q9D2R0-1" }, "isoforms": [ { "isoform_ac": "Q9D2R0-1", "url": "", "sequence": { "sequence": "MSKLARLEREEIMECQVMWEPDSKKDTQMDRFRAAVGTACGLALGNYNDLYHWSVRSYMDFWAEFWKFSGIVYSRMYDEVVDTSKGIADVPEWFRGSRLNYAENLLRHKENDRVALYVAREGREEIVKVTFEELRQQVALFAAAMRKMGVKKGDRVVGYLPNSAHAVEAMLAAASIGAIWSSTSPDFGVNGVLDRFSQIQPKLIFSVEAVVYNGKEHGHLEKLQRVVKGLPDLQRVVLIPYVLPREKIDISKIPNSVFLDDFLASGTGAQAPQLEFEQLPFSHPLFIMFSSGTTGAPKCMVHSAGGTLIQHLKEHMLHGNMTSSDILLYYTTVGWMMWNWMVSALATGASLVLYDGSPLVPTPNVLWDLVDRIGITILGTGAKWLSVLEEKDMKPVETHNLHTLHTILSTGSPLKAQSYEYVYRCIKSSVLLGSISGGTDIISCFMGQNSSIPVYKGEIQARNLGMAVEAWDEEGKAVWGASGELVCTKPIPCQPTHFWNDENGSKYRKAYFSKFPGVWAHGDYCRINPKTGGIIMLGRSDGTLNPNGVRFGSSEIYNIVEAFDEVEDSLCVPQYNRDGEERVVLFLKMASGHTFQPDLVKRIRDAIRLGLSARHVPSLILETRGIPYTLNGKKVEVAVKQVMAGRTVEHRGAFSNPETLDLYRDIPELQDF", "length": 672, "header": "sp|Q9D2R0-1|AACS_MOUSE Isoform 1 of Acetoacetyl-CoA synthetase OS=Mus musculus OX=10090 GN=Aacs PE=1 SV=1 CANONICAL=Q9D2R0-1" }, "locus": { "chromosome": "5", "start_pos": 125593414, "end_pos": 125553041, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000031445", "url": "https://www.ensembl.org/id/ENSMUST00000031445" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000031445", "url": "https://www.ensembl.org/id/ENSMUSP00000031445" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Transcriptional regulation of ketone body-utilizing enzyme, acetoacetyl-CoA synthetase, by C/EBPalpha during adipocyte differentiation.", "journal": "Biochimica et biophysica acta", "date": "2008", "authors": "Hasegawa S, Yamasaki M, Inage T, Takahashi N, Fukui T", "evidence": [ { "database": "RefSeq", "id": "NP_084486", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084486" } ], "reference": [ { "type": "PubMed", "id": "18514076", "url": "https://glygen.org/publication/PubMed/18514076" } ] }, { "title": "Acetoacetyl-CoA synthetase, a ketone body-utilizing enzyme, is controlled by SREBP-2 and affects serum cholesterol levels.", "journal": "Mol. Genet. Metab.", "date": "2012", "authors": "Hasegawa S, Noda K, Maeda A, Matsuoka M, Yamasaki M, Fukui T", "evidence": [ { "database": "UniProtKB", "id": "Q9D2R0", "url": "https://www.uniprot.org/uniprot/Q9D2R0" }, { "database": "RefSeq", "id": "NP_084486", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084486" } ], "reference": [ { "type": "PubMed", "id": "22985732", "url": "https://glygen.org/publication/PubMed/22985732" } ] }, { "title": "Acetoacetyl-CoA synthetase is essential for normal neuronal development.", "journal": "Biochemical and biophysical research communications", "date": "2012", "authors": "Hasegawa S, Kume H, Iinuma S, Yamasaki M, Takahashi N, Fukui T", "evidence": [ { "database": "RefSeq", "id": "NP_084486", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084486" } ], "reference": [ { "type": "PubMed", "id": "23000407", "url": "https://glygen.org/publication/PubMed/23000407" } ] }, { "title": "The role of acetoacetyl-CoA synthetase, a ketone body-utilizing enzyme, in 3T3-L1 adipocyte differentiation.", "journal": "Biological & pharmaceutical bulletin", "date": "2012", "authors": "Hasegawa S, Ikeda Y, Yamasaki M, Fukui T", "evidence": [ { "database": "RefSeq", "id": "NP_084486", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084486" } ], "reference": [ { "type": "PubMed", "id": "23123469", "url": "https://glygen.org/publication/PubMed/23123469" } ] }, { "title": "Site-specific cleavage of acetoacetyl-CoA synthetase by legumain.", "journal": "FEBS letters", "date": "2016", "authors": "Hasegawa S, Inoue D, Yamasaki M, Li C, Imai M, Takahashi N, Fukui T", "evidence": [ { "database": "RefSeq", "id": "NP_084486", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084486" } ], "reference": [ { "type": "PubMed", "id": "27129883", "url": "https://glygen.org/publication/PubMed/27129883" } ] }, { "title": "Transcriptional regulation of acetoacetyl-CoA synthetase by Sp1 in neuroblastoma cells.", "journal": "Biochemical and biophysical research communications", "date": "2018", "authors": "Hasegawa S, Imai M, Yamasaki M, Takahashi N, Fukui T", "evidence": [ { "database": "RefSeq", "id": "NP_084486", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084486" } ], "reference": [ { "type": "PubMed", "id": "29137983", "url": "https://glygen.org/publication/PubMed/29137983" } ] } ], "pathway": [ { "id": "mmu:78894", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:78894", "resource": "KEGG Pathway" }, { "id": "R-MMU-77111", "name": "Synthesis of Ketone Bodies", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-77111", "resource": "Reactome", "description": "Synthesis of Ketone Bodies" } ], "orthologs": [ { "uniprot_canonical_ac": "Q86V21-1", "protein_name": "Acetoacetyl-CoA synthetase", "gene_name": "AACS", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MSKEERPGREEILECQVMWEPDSKKNTQMDRFRAAVGAACGLALESYDDLYHWSVESYSDFWAEFWKFSGIVFSRVYDEVVDTSKGIADVPEWFKGSRLNYAENLLRHKENDRVALYIAREGKEEIVKVTFEELRQEVALFAAAMRKMGVKKGDRVVGYLPNSEHAVEAMLAAASIGAIWSSTSPDFGVNGVLDRFSQIQPKLIFSVEAVVYNGKEHNHMEKLQQVVKGLPDLKKVVVIPYVSSRENIDLSKIPNSVFLDDFLATGTSEQAPQLEFEQLPFSHPLFIMFSSGTTGAPKCMVHSAGGTLIQHLKEHLLHGNMTSSDILLCYTTVGWMMWNWMVSLLATGAAMVLYDGSPLVPTPNVLWDLVDRIGITVLVTGAKWLSVLEEKAMKPVETHSLQMLHTILSTGSPLKAQSYEYVYRCIKSSILLGSISGGTDIISCFMGHNFSLPVYKGEIQARNLGMAVEAWNEEGKAVWGESGELVCTKPIPCQPTHFWNDENGNKYRKAYFSKFPGIWAHGDYCRINPKTGGIVMLGRSDGTLNPNGVRFGSSEIYNIVESFEEVEDSLCVPQYNKYREERVILFLKMASGHAFQPDLVKRIRDAIRMGLSARHVPSLILETKGIPYTLNGKKVEVAVKQIIAGKAVEQGGAFSNPETLDLYRDIPELQGF", "length": 672 }, "evidence": [ { "id": "45232694", "url": "http://www.informatics.jax.org/homology/45232694", "database": "MGI" }, { "id": "Q9D2R0", "url": "https://omabrowser.org/oma/group/Q9D2R0/", "database": "OMA" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q9JMI1-1", "protein_name": "Acetoacetyl-CoA synthetase", "gene_name": "Aacs", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSKLARLEREEIMECQVMWEPDSKKDTQMDRFRAAVGTACGLALGNYDDLYHWSVRSYSDFWAEFWKFSGIVCSRMYDEVVDTSKGIADVPEWFRGSRLNYAENLLRHKENDRVALYVAREGREEIAKVTFEELRQQVALFAAAMRKMGVKKGDRVVGYLPNSAHAVEAMLAAASIGAIWSSTSPDFGVNGVLDRFSQIQPKLIFSVEAVVYNGKEHGHLEKLQRVVKGLPDLQRVVLIPYVLPREKIDISKIPNSMFLDDFLASGTGAQAPQLEFEQLPFSHPLFIMFSSGTTGAPKCMVHSAGGTLIQHLKEHVLHGNMTSSDILLYYTTVGWMMWNWMVSALATGASLVLYDGSPLVPTPNVLWDLVDRIGITILGTGAKWLSVLEEKDMKPMETHNLHTLHTILSTGSPLKAQSYEYVYRCIKSTVLLGSISGGTDIISCFMGQNSSIPVYKGEIQARNLGMAVEAWDEEGKTVWGASGELVCTKPIPCQPTHFWNDENGSKYRKAYFSKYPGVWAHGDYCRINPKTGGIVMLGRSDGTLNPNGVRFGSSEIYNIVEAFDEVEDSLCVPQYNRDGEERVVLFLKMASGHTFQPDLVKHIRDAIRLGLSARHVPSLILETQGIPYTINGKKVEVAVKQVIAGKTVEHRGAFSNPESLDLYRDIPELQDF", "length": 672 }, "evidence": [ { "id": "45232694", "url": "http://www.informatics.jax.org/homology/45232694", "database": "MGI" }, { "id": "Q9D2R0", "url": "https://omabrowser.org/oma/group/Q9D2R0/", "database": "OMA" } ], "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 10, "go_terms": [ { "name": "liver development", "id": "GO:0001889", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001889", "evidence": [ { "database": "UniProtKB", "id": "Q9D2R0", "url": "https://www.uniprot.org/uniprot/Q9D2R0" } ], "pmid": "" }, { "name": "fatty acid metabolic process", "id": "GO:0006631", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006631", "evidence": [ { "database": "UniProtKB", "id": "Q9D2R0", "url": "https://www.uniprot.org/uniprot/Q9D2R0" } ], "pmid": "" }, { "name": "response to nutrient", "id": "GO:0007584", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007584", "evidence": [ { "database": "UniProtKB", "id": "Q9D2R0", "url": "https://www.uniprot.org/uniprot/Q9D2R0" } ], "pmid": "" }, { "name": "positive regulation of insulin secretion", "id": "GO:0032024", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032024", "evidence": [ { "database": "UniProtKB", "id": "Q9D2R0", "url": "https://www.uniprot.org/uniprot/Q9D2R0" } ], "pmid": "" }, { "name": "response to oleic acid", "id": "GO:0034201", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034201", "evidence": [ { "database": "UniProtKB", "id": "Q9D2R0", "url": "https://www.uniprot.org/uniprot/Q9D2R0" } ], "pmid": "" }, { "name": "response to ethanol", "id": "GO:0045471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045471", "evidence": [ { "database": "UniProtKB", "id": "Q9D2R0", "url": "https://www.uniprot.org/uniprot/Q9D2R0" } ], "pmid": "" }, { "name": "cellular response to glucose stimulus", "id": "GO:0071333", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071333", "evidence": [ { "database": "UniProtKB", "id": "Q9D2R0", "url": "https://www.uniprot.org/uniprot/Q9D2R0" } ], "pmid": "" }, { "name": "response to organic cyclic compound", "id": "GO:0014070", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014070", "evidence": [ { "database": "UniProtKB", "id": "Q9D2R0", "url": "https://www.uniprot.org/uniprot/Q9D2R0" } ], "pmid": "" }, { "name": "response to xenobiotic stimulus", "id": "GO:0009410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009410", "evidence": [ { "database": "UniProtKB", "id": "Q9D2R0", "url": "https://www.uniprot.org/uniprot/Q9D2R0" } ], "pmid": "" }, { "name": "response to organonitrogen compound", "id": "GO:0010243", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010243", "evidence": [ { "database": "UniProtKB", "id": "Q9D2R0", "url": "https://www.uniprot.org/uniprot/Q9D2R0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q9D2R0", "url": "https://www.uniprot.org/uniprot/Q9D2R0" } ], "pmid": "" }, { "name": "acetoacetate-CoA ligase activity", "id": "GO:0030729", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030729", "evidence": [ { "database": "UniProtKB", "id": "Q9D2R0", "url": "https://www.uniprot.org/uniprot/Q9D2R0" } ], "pmid": "" }, { "name": "butyrate-CoA ligase activity", "id": "GO:0047760", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047760", "evidence": [ { "database": "UniProtKB", "id": "Q9D2R0", "url": "https://www.uniprot.org/uniprot/Q9D2R0" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q9D2R0", "url": "https://www.uniprot.org/uniprot/Q9D2R0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 320, "end_pos": 322, "annotation": "n_glycosylation_sequon" }, { "start_pos": 449, "end_pos": 451, "annotation": "n_glycosylation_sequon" }, { "start_pos": 503, "end_pos": 505, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "16117", "name": "", "equation": "acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9JMI1-1", "Q86V21-1", "Q9D2R0-1" ], "evidence": [ { "id": "16117", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16117" } ] }, { "id": "R-MMU-5694494", "name": "AACS ligates CoA-SH to ACA, forming ACA-CoA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-191293" ], "enzyme_list": [ "Q9D2R0-1" ], "evidence": [ { "id": "R-MMU-5694494", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5694494" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-191293", "participant_name": "ACA-CoA [cytosol]", "crossref": [ { "id": "C00332", "database": "COMPOUND", "url": "" }, { "id": "57286", "database": "ChEBI", "url": "" }, { "id": "000096014521", "database": "ZINC", "url": "" }, { "id": "57286", "database": "ChEBI", "url": "" }, { "id": "C00332", "database": "COMPOUND", "url": "" }, { "id": "000096014521", "database": "ZINC", "url": "" }, { "id": "57286", "database": "ChEBI", "url": "" }, { "id": "C00332", "database": "COMPOUND", "url": "" }, { "id": "000096014521", "database": "ZINC", "url": "" }, { "id": "C00332", "database": "COMPOUND", "url": "" }, { "id": "57286", "database": "ChEBI", "url": "" }, { "id": "000096014521", "database": "ZINC", "url": "" }, { "id": "C00332", "database": "COMPOUND", "url": "" }, { "id": "57286", "database": "ChEBI", "url": "" }, { "id": "000096014521", "database": "ZINC", "url": "" }, { "id": "C00332", "database": "COMPOUND", "url": "" }, { "id": "57286", "database": "ChEBI", "url": "" }, { "id": "000096014521", "database": "ZINC", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "Q86V21", "gene_name": "AACS", "activity": [ { "ec_number": "6.2.1.16", "activity": "acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q86V21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86V21" } ] }, { "ec_number": "6.2.1.16", "activity": "", "evidence": [ { "id": "Q86V21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86V21" } ] } ] }, { "uniprot_ac": "Q9D2R0", "gene_name": "Aacs", "activity": [ { "ec_number": "6.2.1.16", "activity": "acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q9D2R0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D2R0" } ] }, { "ec_number": "6.2.1.16", "activity": "", "evidence": [ { "id": "Q9D2R0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D2R0" } ] } ] }, { "uniprot_ac": "Q9JMI1", "gene_name": "Aacs", "activity": [ { "ec_number": "6.2.1.16", "activity": "acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate.", "evidence": [ { "id": "Q9JMI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JMI1" } ] }, { "ec_number": "6.2.1.16", "activity": "", "evidence": [ { "id": "Q9JMI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JMI1" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 6 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }