{
    "uniprot_canonical_ac": "Q9D2C6-1",
    "uniprot_ac": "Q9D2C6",
    "uniprot_id": "RPC8_MOUSE",
    "mass": {
        "chemical_mass": 22948.0,
        "monoisotopic_mass": 22948.0
    },
    "refseq": {
        "ac": "NP_084505",
        "name": "DNA-directed RNA polymerase III subunit RPC8",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084505"
    },
    "gene_names": [
        {
            "name": "Polr3h",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q9D2C6",
            "id": "Q9D2C6"
        },
        {
            "name": "5031409G22Rik; RPC8",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084505",
            "id": "NP_084505"
        },
        {
            "name": "Polr3h",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084505",
            "id": "NP_084505"
        }
    ],
    "protein_names": [
        {
            "name": "DNA-directed RNA polymerase III subunit RPC8",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q9D2C6"
        },
        {
            "name": "DNA-directed RNA polymerase III subunit H",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q9D2C6"
        },
        {
            "name": "DNA-directed RNA polymerase III subunit RPC8",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084505",
            "id": "NP_084505"
        },
        {
            "name": "RNA polymerase III subunit C7; DNA-directed RNA polymerase III subunit H",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084505",
            "id": "NP_084505"
        },
        {
            "name": "RNA polymerase III subunit C7",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q9D2C6"
        }
    ],
    "function": [
        {
            "annotation": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNA. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9D2C6",
                    "url": "https://www.uniprot.org/uniprot/Q9D2C6#function"
                }
            ]
        },
        {
            "annotation": "DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "A0A2R8VK29",
                    "url": "https://www.uniprot.org/uniprot/A0A2R8VK29#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "RU369086",
                    "url": "https://www.uniprot.org/uniprot/RU369086#function"
                }
            ]
        },
        {
            "annotation": "Loss-of-function Polr3h mutation in mice caused early embryonic lethality. Mice with homozygous point mutation (Polr3hD50G) were viable but showed delayed pubertal development, characterized by late first estrus or preputial separation. The Polr3hD50G female and male mice showed decreased fertility later in life, associated with small litter size and increased time to pregnancy or to impregnate a female.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_084505",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084505"
                },
                {
                    "database": "PubMed",
                    "id": "30830215",
                    "url": "https://glygen.org/publication/PubMed/30830215"
                }
            ]
        },
        {
            "annotation": "Pol III regulation in the liver thus entails both highly expressed housekeeping genes and genes whose expression can adapt to increased demand.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_084505",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084505"
                },
                {
                    "database": "PubMed",
                    "id": "30597109",
                    "url": "https://glygen.org/publication/PubMed/30597109"
                }
            ]
        },
        {
            "annotation": "Pol III transcription during the diurnal cycle is regulated both in response to nutrients and by the circadian clock, which allows anticipatory Pol III transcription.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_084505",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084505"
                },
                {
                    "database": "PubMed",
                    "id": "28341772",
                    "url": "https://glygen.org/publication/PubMed/28341772"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:5426",
            "recommended_name": {
                "id": "DOID:5426",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:5426",
                "name": "primary ovarian insufficiency",
                "description": "An ovarian disease where ovaries do not produce estrogen despite high levels of circulating gonadotropins in women under 40."
            },
            "synonyms": [
                {
                    "id": "DOID:5426",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:5426",
                    "name": "premature ovarian failure",
                    "description": ""
                },
                {
                    "id": "DOID:5426",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:5426",
                    "name": "hypergonadotropic hypogonadism",
                    "description": ""
                },
                {
                    "id": "DOID:5426",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:5426",
                    "name": "premature menopause",
                    "description": ""
                },
                {
                    "id": "DOID:5426",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:5426",
                    "name": "premature ovarian insufficiency",
                    "description": ""
                },
                {
                    "id": "MONDO:0010706",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010706",
                    "name": "premature ovarian failure 1",
                    "description": "Any primary ovarian failure in which the cause of the disease is a mutation in the FMR1 gene."
                },
                {
                    "id": "MONDO:0010706",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010706",
                    "name": "ovarian failure, premature",
                    "description": ""
                },
                {
                    "id": "MONDO:0010706",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010706",
                    "name": "FMR1 primary ovarian failure",
                    "description": ""
                },
                {
                    "id": "MONDO:0010706",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010706",
                    "name": "fragile x-associated primary ovarian insufficiency",
                    "description": ""
                },
                {
                    "id": "MONDO:0010706",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010706",
                    "name": "premature ovarian failure 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0010706",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010706",
                    "name": "premature ovarian failure type 1",
                    "description": ""
                },
                {
                    "id": "MONDO:0010706",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010706",
                    "name": "primary ovarian failure caused by mutation in FMR1",
                    "description": ""
                },
                {
                    "id": "MONDO:0010706",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010706",
                    "name": "FMR1-related premature ovarian failure",
                    "description": ""
                },
                {
                    "id": "MONDO:0010706",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010706",
                    "name": "FMR1-related primary ovarian insufficiency",
                    "description": ""
                },
                {
                    "id": "MONDO:0010706",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010706",
                    "name": "Pof1",
                    "description": ""
                },
                {
                    "id": "MONDO:0010706",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010706",
                    "name": "familial premature ovarian failure",
                    "description": ""
                },
                {
                    "id": "MONDO:0010706",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010706",
                    "name": "fragile X-associated primary ovarian insufficiency",
                    "description": ""
                },
                {
                    "id": "MONDO:0010706",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010706",
                    "name": "hypergonadotropic ovarian failure, X-linked",
                    "description": ""
                },
                {
                    "id": "MONDO:0010706",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010706",
                    "name": "idiopathic familial premature ovarian failure",
                    "description": ""
                },
                {
                    "id": "MONDO:0010706",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0010706",
                    "name": "premature ovarian failure, X-linked",
                    "description": ""
                },
                {
                    "id": "MIM:311360",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/311360",
                    "name": "Premature ovarian failure 1",
                    "description": "Premature ovarian failure 1"
                }
            ],
            "evidence": [
                {
                    "id": "5426",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:5426"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9D2C6",
                    "url": "https://www.uniprot.org/uniprot/Q9D2C6"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Polr3h",
            "url": "https://www.uniprot.org/uniprot/Q9D2C6",
            "locus": {
                "chromosome": "15",
                "start_pos": 81772429,
                "end_pos": 81810441,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000022476",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000022476"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000022476",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000022476",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd04330",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04330",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "78929",
            "url": "https://www.ncbi.nlm.nih.gov/gene/78929",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR004519",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR004519",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR005576",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR005576",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR012340",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR012340",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR013238",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013238",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036898",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036898",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR045113",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR045113",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:78929",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:78929",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "1926179",
            "url": "http://www.informatics.jax.org/marker/MGI:1926179",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "LGPTLWW",
            "url": "https://omabrowser.org/oma/group/LGPTLWW/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "35529at2759",
            "url": "http://www.orthodb.org/?query=35529at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR12709",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12709",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR12709:SF1",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12709:SF1",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF03876",
            "url": "http://pfam.xfam.org/family/PF03876",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF08292",
            "url": "http://pfam.xfam.org/family/PF08292",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q9D2C6",
            "url": "http://purl.obolibrary.org/obo/PR_Q9D2C6",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "R-MMU-76061",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-76061",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-MMU-76066",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-76066",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "R-MMU-76071",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-76071",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_084505",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084505",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A2R8VK29",
            "url": "https://www.uniprot.org/uniprot/A0A2R8VK29",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A2R8VK29-1",
            "url": "https://www.uniprot.org/uniprot/A0A2R8VK29-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q9D2C6",
            "url": "https://www.uniprot.org/uniprot/Q9D2C6",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q9D2C6-1",
            "url": "https://www.uniprot.org/uniprot/Q9D2C6-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MFVLVEMVDTVRIPPWQFERKLNDSIAEELNKKLANKVVYNVGLCICLFDITKLEDAYVFPGDGASHTKVHFRYVVFHPFLDEILIGKIKGCSPEGVHVSLGFFDDILIPPESLQQPAKFDEAEQVWVWEYETEEGAHDLYMDTGEEIRFRVVDESFVDTSPTGPSSAEAASSSEELPKKEAPYTLVGSISEPGLGLLSWWTSN",
        "length": 204,
        "header": "sp|Q9D2C6-1|RPC8_MOUSE Isoform 1 of DNA-directed RNA polymerase III subunit RPC8  OS=Mus musculus OX=10090 GN=Polr3h PE=1 SV=2 CANONICAL=Q9D2C6-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A2R8VK29-1",
            "url": "",
            "sequence": {
                "sequence": "MFVLVEMVDTVRIPPWQFERKLNDSIAEELNKKLANKVVYNVGLCICLFDITKLEDAYVFPGDGASHTKVSLGFFDDILIPPESLQQPAKFDEAEQVWVWEYETEEGAHDLYMDTGEEIRFRVVDESFVDTSPTGPSSAEAASSSEELPKKEAPYTLVGSISEPGLGLLSWWTSN",
                "length": 175,
                "header": "tr|A0A2R8VK29-1|RPC8_MOUSE Computationally mapped isoform of DNA-directed RNA polymerase III subunit RPC8  OS=Mus musculus OX=10090 GN=Polr3h PE=1 SV=1 CANONICAL=Q9D2C6-1"
            },
            "locus": {
                "chromosome": "15",
                "start_pos": 81810097,
                "end_pos": 81800816,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000230050.2",
                        "url": "https://www.ensembl.org/id/ENSMUST00000230050.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000155181.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000155181.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q9D2C6-1",
            "url": "",
            "sequence": {
                "sequence": "MFVLVEMVDTVRIPPWQFERKLNDSIAEELNKKLANKVVYNVGLCICLFDITKLEDAYVFPGDGASHTKVHFRYVVFHPFLDEILIGKIKGCSPEGVHVSLGFFDDILIPPESLQQPAKFDEAEQVWVWEYETEEGAHDLYMDTGEEIRFRVVDESFVDTSPTGPSSAEAASSSEELPKKEAPYTLVGSISEPGLGLLSWWTSN",
                "length": 204,
                "header": "sp|Q9D2C6-1|RPC8_MOUSE Isoform 1 of DNA-directed RNA polymerase III subunit RPC8  OS=Mus musculus OX=10090 GN=Polr3h PE=1 SV=2 CANONICAL=Q9D2C6-1"
            },
            "locus": {
                "chromosome": "15",
                "start_pos": 81810097,
                "end_pos": 81800816,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000023113",
                        "url": "https://www.ensembl.org/id/ENSMUST00000023113"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000023113",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000023113"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Diurnal regulation of RNA polymerase III transcription is under the control of both the feeding-fasting response and the circadian clock.",
            "journal": "Genome research",
            "date": "2017",
            "authors": "Mange F, Praz V, Migliavacca E, Willis IM, Schutz F, Hernandez N",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_084505",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084505"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "28341772",
                    "url": "https://glygen.org/publication/PubMed/28341772"
                }
            ]
        },
        {
            "title": "Differential regulation of RNA polymerase III genes during liver regeneration.",
            "journal": "Nucleic acids research",
            "date": "2019",
            "authors": "Yeganeh M, Praz V, Carmeli C, Villeneuve D, Rib L, Guex N, Herr W, Delorenzi M, Hernandez N",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_084505",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084505"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "30597109",
                    "url": "https://glygen.org/publication/PubMed/30597109"
                }
            ]
        },
        {
            "title": "Exome Sequencing Reveals the POLR3H Gene as a Novel Cause of Primary Ovarian Insufficiency.",
            "journal": "The Journal of clinical endocrinology and metabolism",
            "date": "2019",
            "authors": "Franca MM, Han X, Funari MFA, Lerario AM, Nishi MY, Fontenele EGP, Domenice S, Jorge AAL, Garcia-Galiano D, Elias CF, Mendonca BB",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_084505",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_084505"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "30830215",
                    "url": "https://glygen.org/publication/PubMed/30830215"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:78929",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:78929",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-MMU-76061",
            "name": "RNA Polymerase III Transcription Initiation From Type 1 Promoter",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-76061",
            "resource": "Reactome",
            "description": "RNA Polymerase III Transcription Initiation From Type 1 Promoter"
        },
        {
            "id": "R-MMU-76066",
            "name": "RNA Polymerase III Transcription Initiation From Type 2 Promoter",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-76066",
            "resource": "Reactome",
            "description": "RNA Polymerase III Transcription Initiation From Type 2 Promoter"
        },
        {
            "id": "R-MMU-76071",
            "name": "RNA Polymerase III Transcription Initiation From Type 3 Promoter",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-76071",
            "resource": "Reactome",
            "description": "RNA Polymerase III Transcription Initiation From Type 3 Promoter"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "B2RZB0-1",
            "protein_name": "DNA-directed RNA polymerase subunit",
            "gene_name": "Polr3h",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MFVLVEMVDTVRIPPWQFERKLNDSIAEELNKKLANKVVYNVGLCICLFDITKLEDAYVFPGDGASHTKVHFRYVVFHPFLDEILIGKIKGCSPEGVHVSLGFFDDILIPPESLQQPAKFDEAEQVWVWEYETEEGAHDLYMDTGEEIRFRVVDESFVDTSPTGPSSAEAASSSEELPKKEAPYTLVGSISEPGLGLLSWWTSN",
                "length": 204
            },
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                {
                    "id": "45236944",
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            "gene_name": "RPC25",
            "tax_id": 559292,
            "organism": "Saccharomyces cerevisiae S288C",
            "sequence": {
                "sequence": "MFILSKIADLVRIPPDQFHRDTISAITHQLNNKFANKIIPNVGLCITIYDLLTVEEGQLKPGDGSSYINVTFRAVVFKPFLGEIVTGWISKCTAEGIKVSLLGIFDDIFIPQNMLFEGCYYTPEESAWIWPMDEETKLYFDVNEKIRFRIEREVFVDVKPKSPKERELEERAQLENEIEGKNEETPQNEKPPAYALLGSCQTDGMGLVSWWE",
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            },
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                    "id": "Q9D2C6",
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                }
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            "uniprot_canonical_ac": "Q9Y535-1",
            "protein_name": "DNA-directed RNA polymerase III subunit RPC8",
            "gene_name": "POLR3H",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MFVLVEMVDTVRIPPWQFERKLNDSIAEELNKKLANKVVYNVGLCICLFDITKLEDAYVFPGDGASHTKVHFRCVVFHPFLDEILIGKIKGCSPEGVHVSLGFFDDILIPPESLQQPAKFDEAEQVWVWEYETEEGAHDLYMDTGEEIRFRVVDESFVDTSPTGPSSADATTSSEELPKKEAPYTLVGSISEPGLGLLSWWTSN",
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            },
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                    "id": "45236944",
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                },
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                    "url": "https://omabrowser.org/oma/group/Q9D2C6/",
                    "database": "OMA"
                }
            ],
            "common_name": "Human"
        }
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                "name": "Molecular Function",
                "total": 2,
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                    {
                        "name": "DNA binding",
                        "id": "GO:0003677",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9D2C6",
                                "url": "https://www.uniprot.org/uniprot/Q9D2C6"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "DNA-directed 5'-3' RNA polymerase activity",
                        "id": "GO:0003899",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003899",
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                            {
                                "database": "UniProtKB",
                                "id": "Q9D2C6",
                                "url": "https://www.uniprot.org/uniprot/Q9D2C6"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
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                        "name": "nucleus",
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                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
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                            {
                                "database": "UniProtKB",
                                "id": "Q9D2C6",
                                "url": "https://www.uniprot.org/uniprot/Q9D2C6"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "DNA-directed RNA polymerase complex",
                        "id": "GO:0000428",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000428",
                        "evidence": [
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                                "database": "UniProtKB",
                                "id": "Q9D2C6",
                                "url": "https://www.uniprot.org/uniprot/Q9D2C6"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nucleoplasm",
                        "id": "GO:0005654",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9D2C6",
                                "url": "https://www.uniprot.org/uniprot/Q9D2C6"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "centrosome",
                        "id": "GO:0005813",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9D2C6",
                                "url": "https://www.uniprot.org/uniprot/Q9D2C6"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "intracellular membrane-bounded organelle",
                        "id": "GO:0043231",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9D2C6",
                                "url": "https://www.uniprot.org/uniprot/Q9D2C6"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "RNA polymerase III complex",
                        "id": "GO:0005666",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005666",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9D2C6",
                                "url": "https://www.uniprot.org/uniprot/Q9D2C6"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 6,
                "go_terms": [
                    {
                        "name": "DNA-templated transcription initiation",
                        "id": "GO:0006352",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006352",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9D2C6",
                                "url": "https://www.uniprot.org/uniprot/Q9D2C6"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "innate immune response",
                        "id": "GO:0045087",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9D2C6",
                                "url": "https://www.uniprot.org/uniprot/Q9D2C6"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "defense response to virus",
                        "id": "GO:0051607",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051607",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9D2C6",
                                "url": "https://www.uniprot.org/uniprot/Q9D2C6"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nucleobase-containing compound metabolic process",
                        "id": "GO:0006139",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006139",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9D2C6",
                                "url": "https://www.uniprot.org/uniprot/Q9D2C6"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "transcription by RNA polymerase III",
                        "id": "GO:0006383",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006383",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9D2C6",
                                "url": "https://www.uniprot.org/uniprot/Q9D2C6"
                            }
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                        "pmid": ""
                    },
                    {
                        "name": "transcription initiation at RNA polymerase III promoter",
                        "id": "GO:0006384",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006384",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9D2C6",
                                "url": "https://www.uniprot.org/uniprot/Q9D2C6"
                            }
                        ],
                        "pmid": ""
                    }
                ]
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            "start_pos": 23,
            "end_pos": 25,
            "annotation": "n_glycosylation_sequon"
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    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
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        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
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        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
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        {
            "name": "homologset.oma",
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}