{
    "uniprot_canonical_ac": "Q9D0A0-1",
    "uniprot_ac": "Q9D0A0",
    "uniprot_id": "DET1_MOUSE",
    "mass": {
        "chemical_mass": 63837.0,
        "monoisotopic_mass": 63837.0
    },
    "refseq": {
        "ac": "NP_083861",
        "name": "DET1 homolog isoform 1",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083861"
    },
    "gene_names": [
        {
            "name": "Det1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q9D0A0",
            "id": "Q9D0A0"
        },
        {
            "name": "2610034H20Rik",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083861",
            "id": "NP_083861"
        },
        {
            "name": "Det1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083861",
            "id": "NP_083861"
        }
    ],
    "protein_names": [
        {
            "name": "DET1 homolog",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q9D0A0"
        },
        {
            "name": "DET1 homolog isoform 1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083861",
            "id": "NP_083861"
        },
        {
            "name": "DET1 homolog; de-etiolated-1 homolog; de-etiolated homolog 1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083861",
            "id": "NP_083861"
        },
        {
            "name": "De-etiolated-1 homolog",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q9D0A0"
        }
    ],
    "function": [
        {
            "annotation": "Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation (By similarity).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9D0A0",
                    "url": "https://www.uniprot.org/uniprot/Q9D0A0#function"
                }
            ]
        },
        {
            "annotation": "Mechanistically, cryptochromes inactivate Cop1 by interacting with Det1, a subunit of the mammalian CRL4(Cop1) complex that is not present in other CRL4s. Through this interaction, the ability of Cop1 to join the CRL4 complex is inhibited; therefore, its substrates accumulate. Thus, the interaction between cryptochromes and Det1 in mammals mirrors the interaction between cryptochromes and Cop1 in planta.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_083861",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083861"
                },
                {
                    "database": "PubMed",
                    "id": "31155351",
                    "url": "https://glygen.org/publication/PubMed/31155351"
                }
            ]
        },
        {
            "annotation": "The role of ABF1/3/4 in det1 germination phenotypes",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_083861",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083861"
                },
                {
                    "database": "PubMed",
                    "id": "29680877",
                    "url": "https://glygen.org/publication/PubMed/29680877"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9D0A0",
                    "url": "https://www.uniprot.org/uniprot/Q9D0A0"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Det1",
            "url": "https://www.uniprot.org/uniprot/Q9D0A0",
            "locus": {
                "chromosome": "7",
                "start_pos": 78471295,
                "end_pos": 78497011,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000030610",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000030610"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000030610",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000030610",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "76375",
            "url": "https://www.ncbi.nlm.nih.gov/gene/76375",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "Q9D0A0",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:Q9D0A0*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR019138",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR019138",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:76375",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:76375",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "1923625",
            "url": "http://www.informatics.jax.org/marker/MGI:1923625",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "ITPCLTI",
            "url": "https://omabrowser.org/oma/group/ITPCLTI/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "8024at2759",
            "url": "http://www.orthodb.org/?query=8024at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR13374",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13374",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR13374:SF3",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13374:SF3",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF09737",
            "url": "http://pfam.xfam.org/family/PF09737",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q9D0A0",
            "url": "http://purl.obolibrary.org/obo/PR_Q9D0A0",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "R-MMU-983168",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983168",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_083861",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083861",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0U1RNK0",
            "url": "https://www.uniprot.org/uniprot/A0A0U1RNK0",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A0U1RNK0-1",
            "url": "https://www.uniprot.org/uniprot/A0A0U1RNK0-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "D3YXC0",
            "url": "https://www.uniprot.org/uniprot/D3YXC0",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "D3YXC0-1",
            "url": "https://www.uniprot.org/uniprot/D3YXC0-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q9D0A0",
            "url": "https://www.uniprot.org/uniprot/Q9D0A0",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q9D0A0-1",
            "url": "https://www.uniprot.org/uniprot/Q9D0A0-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MDHHVSTIKPRRIQNQNVIHRLERRRISSGKAGTHWHQVRVFHQNVFPNFTVVNVEKPPCFLRKFSPDGRYFIAFSSDQTSLEIYEYQGCQAAEDLLQGYEGEILSNGNDQRSVSIRGRLFERFFVLLHITNVAANGEHLNRECSLFTDDCRCVIVGSAAYLPDEPHPPFYEVYRNSESVTPNPRSPLEDYSLHIIDLHTGRLCDTRTFKCDKVVLSHNQGLYLYKNILAILSVQQQTIHVFQVTPEGTFIDVRTIGRFCYEDDLLTVSAVFPEVQRDSQTGMANPFRDPFINSLKHRLLVYLWRRAEQDGSAMAKRRFFQYFDQLRQLRMWKMQLLDENHLFIKYTSEDVVTLRVTDPSQASFFVVYNMVTTEVIAVFENTSDELLELFENFCDLFRNATLHSEVQFPCSASSNNFARQIQRRFKDTIINAKYGGHTEAVRRLLGQLPISAQSYSGSPYLDLSLFSYDDKWVSVMERPKTCGDHPIRFYARDSGLLKFEIQAGLLGRPINHTVRRLVAFTFHPFEPFAISVQRTNAEYVVNFHMRHCCT",
        "length": 550,
        "header": "sp|Q9D0A0-1|DET1_MOUSE Isoform 1 of DET1 homolog  OS=Mus musculus OX=10090 GN=Det1 PE=2 SV=2 CANONICAL=Q9D0A0-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A0U1RNK0-1",
            "url": "",
            "sequence": {
                "sequence": "XLSLFSYDDKWVSVMERPKTCGDHPIRLALIPELRRSSCLDWPGVDYSFRAFRSIQFHVPILDPWDFLEAGV",
                "length": 72,
                "header": "tr|A0A0U1RNK0-1|DET1_MOUSE Computationally mapped isoform of DET1 homolog  OS=Mus musculus OX=10090 GN=Det1 PE=2 SV=1 CANONICAL=Q9D0A0-1"
            },
            "locus": {
                "chromosome": "7",
                "start_pos": 78483936,
                "end_pos": 78472871,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000138062.3",
                        "url": "https://www.ensembl.org/id/ENSMUST00000138062.3"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000145597.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000145597.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "D3YXC0-1",
            "url": "",
            "sequence": {
                "sequence": "MHNWKFVGLSGGKQLIQHRKQNLQSCHCSQASFFVVYNMVTTEVIAVFENTSDELLELFENFCDLFRNATLHSEVQFPCSASSNNFARQIQRRFKDTIINAKYGGHTEAVRRLLGQLPISAQSYSGSPYLDLSLFSYDDKWVSVMERPKTCGDHPIRFYARDSGLLKFEIQAGLLGRPINHTVRRLVAFTFHPFEPFAISVQRTNAEYVVNFHMRHCCT",
                "length": 219,
                "header": "tr|D3YXC0-1|DET1_MOUSE Computationally mapped isoform of DET1 homolog  OS=Mus musculus OX=10090 GN=Det1 PE=2 SV=2 CANONICAL=Q9D0A0-1"
            },
            "locus": {
                "chromosome": "7",
                "start_pos": 78492673,
                "end_pos": 78477674,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000107431.3",
                        "url": "https://www.ensembl.org/id/ENSMUST00000107431.3"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000103054.3",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000103054.3"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q9D0A0-1",
            "url": "",
            "sequence": {
                "sequence": "MDHHVSTIKPRRIQNQNVIHRLERRRISSGKAGTHWHQVRVFHQNVFPNFTVVNVEKPPCFLRKFSPDGRYFIAFSSDQTSLEIYEYQGCQAAEDLLQGYEGEILSNGNDQRSVSIRGRLFERFFVLLHITNVAANGEHLNRECSLFTDDCRCVIVGSAAYLPDEPHPPFYEVYRNSESVTPNPRSPLEDYSLHIIDLHTGRLCDTRTFKCDKVVLSHNQGLYLYKNILAILSVQQQTIHVFQVTPEGTFIDVRTIGRFCYEDDLLTVSAVFPEVQRDSQTGMANPFRDPFINSLKHRLLVYLWRRAEQDGSAMAKRRFFQYFDQLRQLRMWKMQLLDENHLFIKYTSEDVVTLRVTDPSQASFFVVYNMVTTEVIAVFENTSDELLELFENFCDLFRNATLHSEVQFPCSASSNNFARQIQRRFKDTIINAKYGGHTEAVRRLLGQLPISAQSYSGSPYLDLSLFSYDDKWVSVMERPKTCGDHPIRFYARDSGLLKFEIQAGLLGRPINHTVRRLVAFTFHPFEPFAISVQRTNAEYVVNFHMRHCCT",
                "length": 550,
                "header": "sp|Q9D0A0-1|DET1_MOUSE Isoform 1 of DET1 homolog  OS=Mus musculus OX=10090 GN=Det1 PE=2 SV=2 CANONICAL=Q9D0A0-1"
            },
            "locus": {
                "chromosome": "7",
                "start_pos": 78494002,
                "end_pos": 78477674,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000032839",
                        "url": "https://www.ensembl.org/id/ENSMUST00000032839"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000032839",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000032839"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Role of Arabidopsis ABF1/3/4 during det1 germination in salt and osmotic stress conditions.",
            "journal": "Plant molecular biology",
            "date": "2018",
            "authors": "Fernando VCD, Al Khateeb W, Belmonte MF, Schroeder DF",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_083861",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083861"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "29680877",
                    "url": "https://glygen.org/publication/PubMed/29680877"
                }
            ]
        },
        {
            "title": "Cryptochromes-Mediated Inhibition of the CRL4(Cop1)-Complex Assembly Defines an Evolutionary Conserved Signaling Mechanism.",
            "journal": "Current biology : CB",
            "date": "2019",
            "authors": "Rizzini L, Levine DC, Perelis M, Bass J, Peek CB, Pagano M",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_083861",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083861"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "31155351",
                    "url": "https://glygen.org/publication/PubMed/31155351"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:76375",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:76375",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-MMU-983168",
            "name": "Antigen processing: Ubiquitination & Proteasome degradation",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983168",
            "resource": "Reactome",
            "description": "Antigen processing: Ubiquitination & Proteasome degradation"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "F7EXD0-1",
            "protein_name": "DET1 partner of COP1 E3 ubiquitin ligase",
            "gene_name": "Det1",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MDHHVSTIKPRRIQNQNVIHRLERRRISSGRAGTHWHQVRVFHQNVFPNFTVVNVEKPPCFLRKFSPDGRYFIAFSSDQTSLEIYEYQGCQAAEDLLQGYEGEILSNGNDQRSVSIRGRLFERFFVLLHITNVAANGEHLNRECSLFTDDCRCVIVGSAAYLPDEPHPPFYEVYRNSESVTPNPRSPLEDYSLHIIDLHTGRLCDTRTFKCDKVVLSHNQGLYLYKNILAILSVQQQTIHVFQVTPEGTFIDVRTIGRFCYEDDLLTVSAVFPEVQRDSQTGMANPFRDPFINSLKHRLLVYLWRRAEQDGSAMAKRRFFQYFDQLRQLRMWKMQLLDENHLFIKYTSEDVVTLRVTDPSQASFFVVYNMVTTEVIAVFENTSDELLELFENFCDLFRNATLHSEVQFPCSASSNNFARQIQRRFKDTIINAKYGGHTEAVRRLLGQLPISAQSYSGSPYLDLSLFSYDDKWVSVMERPKTCGDHPIRFYARDSGLLKFEIQAGLLGRPINHTVRRLVAFTFHPFEPFAISVQRTNAEYVVNFHMRHCCT",
                "length": 550
            },
            "evidence": [
                {
                    "id": "45237450",
                    "url": "http://www.informatics.jax.org/homology/45237450",
                    "database": "MGI"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q7L5Y6-1",
            "protein_name": "DET1 homolog",
            "gene_name": "DET1",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MDHHVSTIKPRRIQNQNVIHRLERRRISSGKAGTHWHQVRVFHQNVFPNFTVVNVEKPPCFLRKFSPDGRYFIAFSSDQTSLEIYEYQGCQAAEDLLQGYEGEILSNGNDQRSVNIRGRLFERFFVLLHITNVAANGEHLNRECSLFTDDCRCVIVGSAAYLPDEPHPPFFEVYRNSESVTPNPRSPLEDYSLHIIDLHTGRLCDTRTFKCDKVVLSHNQGLYLYKNILAILSVQQQTIHVFQVTPEGTFIDVRTIGRFCYEDDLLTVSAVFPEVQRDSQTGMANPFRDPFINSLKHRLLVYLWRRAEQDGSAMAKRRFFQYFDQLRQLRMWKMQLLDENHLFIKYTSEDVVTLRVTDPSQASFFVVYNMVTTEVIAVFENTSDELLELFENFCDLFRNATLHSEVQFPCSASSNNFARQIQRRFKDTIINAKYGGHTEAVRRLLGQLPISAQSYSGSPYLDLSLFSYDDKWVSVMERPKTCGDHPIRFYARDSGLLKFEIQAGLLGRPINHTVRRLVAFTFHPFEPFAISVQRTNAEYVVNFHMRHCCT",
                "length": 550
            },
            "evidence": [
                {
                    "id": "45237450",
                    "url": "http://www.informatics.jax.org/homology/45237450",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 4,
                "go_terms": [
                    {
                        "name": "Cul4A-RING E3 ubiquitin ligase complex",
                        "id": "GO:0031464",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031464",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9D0A0",
                                "url": "https://www.uniprot.org/uniprot/Q9D0A0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nucleus",
                        "id": "GO:0005634",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9D0A0",
                                "url": "https://www.uniprot.org/uniprot/Q9D0A0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cullin-RING ubiquitin ligase complex",
                        "id": "GO:0031461",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031461",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9D0A0",
                                "url": "https://www.uniprot.org/uniprot/Q9D0A0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "Cul4-RING E3 ubiquitin ligase complex",
                        "id": "GO:0080008",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0080008",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9D0A0",
                                "url": "https://www.uniprot.org/uniprot/Q9D0A0"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Molecular Function",
                "total": 3,
                "go_terms": [
                    {
                        "name": "ubiquitin protein ligase binding",
                        "id": "GO:0031625",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031625",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9D0A0",
                                "url": "https://www.uniprot.org/uniprot/Q9D0A0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "protein-containing complex binding",
                        "id": "GO:0044877",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044877",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9D0A0",
                                "url": "https://www.uniprot.org/uniprot/Q9D0A0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "ubiquitin ligase-substrate adaptor activity",
                        "id": "GO:1990756",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990756",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9D0A0",
                                "url": "https://www.uniprot.org/uniprot/Q9D0A0"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 3,
                "go_terms": [
                    {
                        "name": "protein ubiquitination",
                        "id": "GO:0016567",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9D0A0",
                                "url": "https://www.uniprot.org/uniprot/Q9D0A0"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "positive regulation of proteasomal ubiquitin-dependent protein catabolic process",
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