{ "uniprot_canonical_ac": "Q9CXY6-1", "uniprot_ac": "Q9CXY6", "uniprot_id": "ILF2_MOUSE", "mass": { "chemical_mass": 43062.0, "monoisotopic_mass": 43062.0 }, "refseq": { "ac": "NP_080650", "name": "interleukin enhancer-binding factor 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080650" }, "gene_names": [ { "name": "Ilf2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q9CXY6", "id": "Q9CXY6" }, { "name": "6230405A16Rik; TEG-267; Tex261; Tex267", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080650", "id": "NP_080650" }, { "name": "Ilf2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080650", "id": "NP_080650" }, { "name": "Nf45", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9CXY6", "id": "Q9CXY6" } ], "protein_names": [ { "name": "Interleukin enhancer-binding factor 2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q9CXY6" }, { "name": "Nuclear factor of activated T-cells 45 kDa", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9CXY6" }, { "name": "interleukin enhancer-binding factor 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080650", "id": "NP_080650" }, { "name": "nuclear factor of activated T-cells 45 kDa; testis expressed gene 267", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080650", "id": "NP_080650" } ], "function": [ { "annotation": "Chromatin-interacting protein that forms a stable heterodimer with interleukin enhancer-binding factor 3/ILF3 and plays a role in several biological processes including transcription, innate immunity or cell growth (PubMed:10574923). Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus. Together with ILF3, forms an RNA-binding complex that is required for mitotic progression and cytokinesis by regulating the expression of a cluster of mitotic genes. Mechanistically, competes with STAU1/STAU2-mediated mRNA decay. Also plays a role in the inhibition of various viruses including Japanese encephalitis virus or enterovirus 71 (By similarity) (PubMed:10574923).", "evidence": [ { "database": "UniProtKB", "id": "Q9CXY6", "url": "https://www.uniprot.org/uniprot/Q9CXY6#function" }, { "database": "UniProtKB", "id": "Q12905", "url": "https://www.uniprot.org/uniprot/Q12905#function" }, { "database": "PubMed", "id": "10574923", "url": "https://glygen.org/publication/PubMed/10574923" } ] }, { "annotation": "Data support a model in which NF45, NF90, and NF110 operate in feedback loops that enable them, through both overlapping and independent targets, to help balance the push and pull of pluripotency and differentiation cues.", "evidence": [ { "database": "RefSeq", "id": "NP_080650", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080650" }, { "database": "PubMed", "id": "28487382", "url": "https://glygen.org/publication/PubMed/28487382" } ] }, { "annotation": "NF90-NF45 complex induces centronuclear myopathy through increased dynamin 2 expression by an NF90-NF45-induced reduction of miR-133a expression in vivo.", "evidence": [ { "database": "RefSeq", "id": "NP_080650", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080650" }, { "database": "PubMed", "id": "25918244", "url": "https://glygen.org/publication/PubMed/25918244" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q9CXY6", "url": "https://www.uniprot.org/uniprot/Q9CXY6" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Ilf2", "url": "https://www.uniprot.org/uniprot/Q9CXY6", "locus": { "chromosome": "3", "start_pos": 90395686, "end_pos": 90383433, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000001016", "url": "https://www.ensembl.org/id/ENSMUSG00000001016" } ] } } ], "crossref": [ { "id": "ENSMUSG00000001016", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000001016", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "67781", "url": "https://www.ncbi.nlm.nih.gov/gene/67781", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q9CXY6", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q9CXY6*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR006561", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006561", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043519", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043519", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:67781", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:67781", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1915031", "url": "http://www.informatics.jax.org/marker/MGI:1915031", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "Q9CXY6", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9CXY6", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "YLAIEMS", "url": "https://omabrowser.org/oma/group/YLAIEMS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5388448at2759", "url": "http://www.orthodb.org/?query=5388448at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46447", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46447", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46447:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46447:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "4AT7", "url": "https://www.rcsb.org/structure/4AT7", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4AT8", "url": "https://www.rcsb.org/structure/4AT8", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4AT9", "url": "https://www.rcsb.org/structure/4AT9", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4ATB", "url": "https://www.rcsb.org/structure/4ATB", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF07528", "url": "http://pfam.xfam.org/family/PF07528", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q9CXY6", "url": "http://purl.obolibrary.org/obo/PR_Q9CXY6", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-6798695", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6798695", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-9833482", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9833482", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_080650", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080650", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q9CXY6", "url": "https://www.uniprot.org/uniprot/Q9CXY6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9CXY6-1", "url": "https://www.uniprot.org/uniprot/Q9CXY6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRGDRGRGRGGRFGSRGGPGGGFRPFVPHIPFDFYLCEMAFPRVKPAPDETSFSEALLKRNQDLAPNSAEQASILSLVTKINNVIDNLIVAPGTFEVQIEEVRQVGSYKKGTMTTGHNVADLVVILKILPTLEAVAALGNKVVESLRAQDPSEVLTMLTNETGFEISSSDATVKILITTVPPNLRKLDPELHLDIKVLQSALAAIRHARWFEENASQSTVKVLIRLLKDLRIRFPGFEPLTPWILDLLGHYAVMNNPTRQPLALNVAYRRCLQILAAGLFLPGSVGITDPCESGNFRVHTVMTLEQQDMVCYTAQTLVRILSHGGFRKILGQEGDASYLASEISTWDGVIVTPSEKAYEKPPEKKEGEEEEENTEEPPQGEEEESMETQE", "length": 390, "header": "sp|Q9CXY6-1|ILF2_MOUSE Isoform 1 of Interleukin enhancer-binding factor 2 OS=Mus musculus OX=10090 GN=Ilf2 PE=1 SV=1 CANONICAL=Q9CXY6-1" }, "isoforms": [ { "isoform_ac": "Q9CXY6-1", "url": "", "sequence": { "sequence": "MRGDRGRGRGGRFGSRGGPGGGFRPFVPHIPFDFYLCEMAFPRVKPAPDETSFSEALLKRNQDLAPNSAEQASILSLVTKINNVIDNLIVAPGTFEVQIEEVRQVGSYKKGTMTTGHNVADLVVILKILPTLEAVAALGNKVVESLRAQDPSEVLTMLTNETGFEISSSDATVKILITTVPPNLRKLDPELHLDIKVLQSALAAIRHARWFEENASQSTVKVLIRLLKDLRIRFPGFEPLTPWILDLLGHYAVMNNPTRQPLALNVAYRRCLQILAAGLFLPGSVGITDPCESGNFRVHTVMTLEQQDMVCYTAQTLVRILSHGGFRKILGQEGDASYLASEISTWDGVIVTPSEKAYEKPPEKKEGEEEEENTEEPPQGEEEESMETQE", "length": 390, "header": "sp|Q9CXY6-1|ILF2_MOUSE Isoform 1 of Interleukin enhancer-binding factor 2 OS=Mus musculus OX=10090 GN=Ilf2 PE=1 SV=1 CANONICAL=Q9CXY6-1" }, "locus": { "chromosome": "3", "start_pos": 90394923, "end_pos": 90383548, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000001042", "url": "https://www.ensembl.org/id/ENSMUST00000001042" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000001042", "url": "https://www.ensembl.org/id/ENSMUSP00000001042" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "Q9CXY6", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9CXY6" }, { "id": "33300544", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33300544" }, { "id": "29187734", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29187734" } ] } ], "phosphorylation": [ { "start_pos": 388, "end_pos": 388, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q9CXY6", "url": "https://www.uniprot.org/uniprot/Q9CXY6" } ], "site_lbl": "Thr388" }, { "start_pos": 52, "end_pos": 52, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9CXY6", "url": "https://www.uniprot.org/uniprot/Q9CXY6" } ], "site_lbl": "Ser52" }, { "start_pos": 68, "end_pos": 68, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9CXY6", "url": "https://www.uniprot.org/uniprot/Q9CXY6" } ], "site_lbl": "Ser68" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Autoantibodies define a family of proteins with conserved double-stranded RNA-binding domains as well as DNA binding activity.", "journal": "J. Biol. Chem.", "date": "1999", "authors": "Satoh M, Shaheen VM, Kao PN, Okano T, Shaw M, Yoshida H, Richards HB, Reeves WH", "evidence": [ { "database": "UniProtKB", "id": "Q9CXY6", "url": "https://www.uniprot.org/uniprot/Q9CXY6" } ], "reference": [ { "type": "PubMed", "id": "10574923", "url": "https://glygen.org/publication/PubMed/10574923" } ] }, { "title": "Ilf2 is regulated during meiosis and associated to transcriptionally active chromatin.", "journal": "Mech. Dev.", "date": "2002", "authors": "Lopez-Fernandez LA, Parraga M, del Mazo J", "evidence": [ { "database": "UniProtKB", "id": "Q9CXY6", "url": "https://www.uniprot.org/uniprot/Q9CXY6" } ], "reference": [ { "type": "PubMed", "id": "11804788", "url": "https://glygen.org/publication/PubMed/11804788" } ] }, { "title": "Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.", "journal": "Mol. Cell. Proteomics", "date": "2014", "authors": "Guo A, Gu H, Zhou J, Mulhern D, Wang Y, Lee KA, Yang V, Aguiar M, Kornhauser J, Jia X, Ren J, Beausoleil SA, Silva JC, Vemulapalli V, Bedford MT, Comb MJ", "evidence": [ { "database": "UniProtKB", "id": "Q9CXY6", "url": "https://www.uniprot.org/uniprot/Q9CXY6" } ], "reference": [ { "type": "PubMed", "id": "24129315", "url": "https://glygen.org/publication/PubMed/24129315" } ] }, { "title": "Overexpression of NF90-NF45 Represses Myogenic MicroRNA Biogenesis, Resulting in Development of Skeletal Muscle Atrophy and Centronuclear Muscle Fibers.", "journal": "Molecular and cellular biology", "date": "2015", "authors": "Todaka H, Higuchi T, Yagyu K, Sugiyama Y, Yamaguchi F, Morisawa K, Ono M, Fukushima A, Tsuda M, Taniguchi T, Sakamoto S", "evidence": [ { "database": "RefSeq", "id": "NP_080650", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080650" } ], "reference": [ { "type": "PubMed", "id": "25918244", "url": "https://glygen.org/publication/PubMed/25918244" } ] }, { "title": "NF45 and NF90/NF110 coordinately regulate ESC pluripotency and differentiation.", "journal": "RNA (New York, N.Y.)", "date": "2017", "authors": "Ye J, Jin H, Pankov A, Song JS, Blelloch R", "evidence": [ { "database": "RefSeq", "id": "NP_080650", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_080650" } ], "reference": [ { "type": "PubMed", "id": "28487382", "url": "https://glygen.org/publication/PubMed/28487382" } ] }, { "title": "O-GlcNAcylation is required for B cell homeostasis and antibody responses.", "journal": "Nature communications", "date": "2017", "authors": "Wu JL, Chiang MF, Hsu PH, Tsai DY, Hung KH, Wang YH, Angata T, Lin KI", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9CXY6", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9CXY6" } ], "reference": [ { "type": "PubMed", "id": "29187734", "url": "https://glygen.org/publication/PubMed/29187734" } ] }, { "title": "O-GlcNAcylation regulates dopamine neuron function, survival and degeneration in Parkinson disease.", "journal": "Brain : a journal of neurology", "date": "2020", "authors": "Lee BE, Kim HY, Kim HJ, Jeong H, Kim BG, Lee HE, Lee J, Kim HB, Lee SE, Yang YR, Yi EC, Hanover JA, Myung K, Suh PG, Kwon T, Kim JI", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q9CXY6", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9CXY6" } ], "reference": [ { "type": "PubMed", "id": "33300544", "url": "https://glygen.org/publication/PubMed/33300544" } ] }, { "title": "Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90.", "journal": "J. Biol. Chem.", "date": "1994", "authors": "Kao PN, Chen L, Brock G, Ng J, Kenny J, Smith AJ, Corthesy B", "evidence": [ { "database": "UniProtKB", "id": "Q9CXY6", "url": "https://www.uniprot.org/uniprot/Q9CXY6" } ], "reference": [ { "type": "PubMed", "id": "7519613", "url": "https://glygen.org/publication/PubMed/7519613" } ] } ], "pathway": [ { "id": "mmu:67781", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:67781", "resource": "KEGG Pathway" }, { "id": "R-MMU-6798695", "name": "Neutrophil degranulation", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6798695", "resource": "Reactome", "description": "Neutrophil degranulation" }, { "id": "R-MMU-9833482", "name": "PKR-mediated signaling", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9833482", "resource": "Reactome", "description": "PKR-mediated signaling" } ], "orthologs": [ { "uniprot_canonical_ac": "Q12905-1", "protein_name": "Interleukin enhancer-binding factor 2", "gene_name": "ILF2", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MRGDRGRGRGGRFGSRGGPGGGFRPFVPHIPFDFYLCEMAFPRVKPAPDETSFSEALLKRNQDLAPNSAEQASILSLVTKINNVIDNLIVAPGTFEVQIEEVRQVGSYKKGTMTTGHNVADLVVILKILPTLEAVAALGNKVVESLRAQDPSEVLTMLTNETGFEISSSDATVKILITTVPPNLRKLDPELHLDIKVLQSALAAIRHARWFEENASQSTVKVLIRLLKDLRIRFPGFEPLTPWILDLLGHYAVMNNPTRQPLALNVAYRRCLQILAAGLFLPGSVGITDPCESGNFRVHTVMTLEQQDMVCYTAQTLVRILSHGGFRKILGQEGDASYLASEISTWDGVIVTPSEKAYEKPPEKKEGEEEEENTEEPPQGEEEESMETQE", "length": 390 }, "evidence": [ { "id": "45232436", "url": "http://www.informatics.jax.org/homology/45232436", "database": "MGI" }, { "id": "Q9CXY6", "url": "https://omabrowser.org/oma/group/Q9CXY6/", "database": "OMA" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q7TP98-1", "protein_name": "Interleukin enhancer-binding factor 2", "gene_name": "Ilf2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVSTHLTSTTLPDCYRSLIVNSELGSSALMDLNSPSFLYPLLHTPADKGTLCTYQAALGKVYASLEVIGVGDDKLQAVHGLNGGKPHRDILGSRITRPTGIKPLCLPRHILAYDWLAQSLLGIVIGSISLAYNELLMMEKLKGFRPFVPHIPFDFYLCEMAFPRVKPAPDETSFSEALLKRNQDLAPNSAEQQIEEVRQVGSYKKGTMTTGHNVADLVVILKILPTFLTMLTNETGFEISSSDATVKILITTVPPNLRKLDPELHLDIKVLQSALAAIRHARWFEENASQSTVKVLIRLLKDLRIRFPGFEPLTPWILDLLGHYAVMNNPTRQPLALNVAYRRCLQILAAGLFLPGSVGITDPCESGNFRVHTVMTLEQQDMVCYTAQTLVRILSHGGFRKILGQEGDASYLASEISTWDGVIVTPSEKAYEKPPEKKEGEEEEENTEEPPQGEEEESMETQE", "length": 463 }, "evidence": [ { "id": "45232436", "url": "http://www.informatics.jax.org/homology/45232436", "database": "MGI" } ], "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "Q9CXY6", "url": "https://www.uniprot.org/uniprot/Q9CXY6" } ], "pmid": "" }, { "name": "double-stranded RNA binding", "id": "GO:0003725", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003725", "evidence": [ { "database": "UniProtKB", "id": "Q9CXY6", "url": "https://www.uniprot.org/uniprot/Q9CXY6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q9CXY6", "url": "https://www.uniprot.org/uniprot/Q9CXY6" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "Q9CXY6", "url": "https://www.uniprot.org/uniprot/Q9CXY6" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "Q9CXY6", "url": "https://www.uniprot.org/uniprot/Q9CXY6" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q9CXY6", "url": "https://www.uniprot.org/uniprot/Q9CXY6" } ], "pmid": "" }, { "name": "ribonucleoprotein complex", "id": "GO:1990904", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990904", "evidence": [ { "database": "UniProtKB", "id": "Q9CXY6", "url": "https://www.uniprot.org/uniprot/Q9CXY6" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "Q9CXY6", "url": "https://www.uniprot.org/uniprot/Q9CXY6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 160, "end_pos": 162, "annotation": "n_glycosylation_sequon" }, { "start_pos": 214, "end_pos": 216, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Ubiquitinated at Lys-45 by CRBN with polyubiquitin chains by the CUL4-RING E3 ligase (CRL4-CRBN) and then degraded by the proteasome.", "evidence": [ { "database": "UniProtKB", "id": "Q9CXY6", "url": "https://www.uniprot.org/uniprot/Q9CXY6" }, { "database": "PubMed", "id": "Q12905", "url": "https://glygen.org/publication/PubMed/Q12905" } ] } ], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", 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