{
    "uniprot_canonical_ac": "Q9CW42-1",
    "uniprot_ac": "Q9CW42",
    "uniprot_id": "MARC1_MOUSE",
    "mass": {
        "chemical_mass": 37979.0,
        "monoisotopic_mass": 37979.0
    },
    "refseq": {
        "ac": "NP_001277202",
        "name": "mitochondrial amidoxime-reducing component 1",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277202"
    },
    "gene_names": [
        {
            "name": "Mtarc1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q9CW42",
            "id": "Q9CW42"
        },
        {
            "name": "1300013F15Rik; Marc1; Mosc1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277202",
            "id": "NP_001277202"
        },
        {
            "name": "Marc1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q9CW42",
            "id": "Q9CW42"
        },
        {
            "name": "Mosc1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q9CW42",
            "id": "Q9CW42"
        },
        {
            "name": "Mtarc1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277202",
            "id": "NP_001277202"
        }
    ],
    "protein_names": [
        {
            "name": "Mitochondrial amidoxime-reducing component 1",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q9CW42"
        },
        {
            "name": "1.7.-.-",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q9CW42"
        },
        {
            "name": "MOSC domain-containing protein 1, mitochondrial; moco sulfurase C-terminal domain-containing protein 1; molybdenum cofactor sulfurase C-terminal domain-containing protein 1; MOCO sulphurase C-terminal domain containing 1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277202",
            "id": "NP_001277202"
        },
        {
            "name": "MOSC domain-containing protein 1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q9CW42"
        },
        {
            "name": "Moco sulfurase C-terminal domain-containing protein 1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q9CW42"
        },
        {
            "name": "Molybdenum cofactor sulfurase C-terminal domain-containing protein 1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q9CW42"
        },
        {
            "name": "mARC1",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q9CW42"
        },
        {
            "name": "mitochondrial amidoxime-reducing component 1",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277202",
            "id": "NP_001277202"
        }
    ],
    "function": [
        {
            "annotation": "Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles. As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability. May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis. Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9CW42",
                    "url": "https://www.uniprot.org/uniprot/Q9CW42#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q5VT66",
                    "url": "https://www.uniprot.org/uniprot/Q5VT66#function"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9CW42",
                    "url": "https://www.uniprot.org/uniprot/Q9CW42"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Mtarc1",
            "url": "https://www.uniprot.org/uniprot/Q9CW42",
            "locus": {
                "chromosome": "1",
                "start_pos": 184518964,
                "end_pos": 184543510,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000026621",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000026621"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000026621",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000026621",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "66112",
            "url": "https://www.ncbi.nlm.nih.gov/gene/66112",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR005302",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR005302",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR005303",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR005303",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR011037",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011037",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:66112",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:66112",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "1913362",
            "url": "http://www.informatics.jax.org/marker/MGI:1913362",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "YPVKGCA",
            "url": "https://omabrowser.org/oma/group/YPVKGCA/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "5490564at2759",
            "url": "http://www.orthodb.org/?query=5490564at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR14237",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14237",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR14237:SF25",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14237:SF25",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF03473",
            "url": "http://pfam.xfam.org/family/PF03473",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF03476",
            "url": "http://pfam.xfam.org/family/PF03476",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q9CW42",
            "url": "http://purl.obolibrary.org/obo/PR_Q9CW42",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "R-MMU-211945",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-211945",
            "database": "Reactome",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "NP_001277202",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277202",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "61644",
            "url": "https://www.rhea-db.org/rhea/61644",
            "database": "Rhea",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "A0A087WPC2",
            "url": "https://www.uniprot.org/uniprot/A0A087WPC2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A087WPC2-1",
            "url": "https://www.uniprot.org/uniprot/A0A087WPC2-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "D3YZZ3",
            "url": "https://www.uniprot.org/uniprot/D3YZZ3",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "D3YZZ3-1",
            "url": "https://www.uniprot.org/uniprot/D3YZZ3-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q9CW42",
            "url": "https://www.uniprot.org/uniprot/Q9CW42",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q9CW42-1",
            "url": "https://www.uniprot.org/uniprot/Q9CW42-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MGAGSWALTLFGFSAFRVPGQPRSTWLGVAALGLAAVALGTVAWRRARPRRRRRLQQVGTVAQLWIYPIKSCKGLSVSEAECTAMGLRYGHLRDRFWLVINEEGNMVTARQEPRLVLISLTCEDDTLTLSAAYTKDLLLPITPPATNPLLQCRVHGLEIQGRDCGEDAAQWVSSFLKMQSCRLVHFEPHMRPRSSRQMKAVFRTKDQVAYSDASPFLVLSEASLEDLNSRLERRVKATNFRPNIVISGCGVYAEDSWNEVLIGDVELKRVMACTRCLLTTVDPDTGISDRKEPLETLKSYRLCDPSEQALYGKLPIFGQYFALENPGTIRVGDPVYLLGQ",
        "length": 340,
        "header": "sp|Q9CW42-1|MARC1_MOUSE Isoform 1 of Mitochondrial amidoxime-reducing component 1  OS=Mus musculus OX=10090 GN=Mtarc1 PE=1 SV=2 CANONICAL=Q9CW42-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A087WPC2-1",
            "url": "",
            "sequence": {
                "sequence": "MVTARQEPRLVLISLTCEDDTLTLSAAYTKDLLLPITPPATNPLLQCRVHGLEIQGRDCGEDAAQWVSSFLKMQSCRLVHFEPHMRPRSSRQMKAVFRTKDQVAYSDASPFLVLSEASLEDLNSRLERRVKATNFRPNIVISGCGVYAEDSWNEVLIGDVELKRVMACTRCLLTTVDPDTGISDRKEPLETLKSYRLCDPSEQALYGKLPIFGQYFALENPGTIRVGDPVYLLGQ",
                "length": 235,
                "header": "tr|A0A087WPC2-1|A0A087WPC2_MOUSE Computationally mapped isoform of Mitochondrial amidoxime reducing component 1  OS=Mus musculus OX=10090 GN=Mtarc1 PE=1 SV=1 CANONICAL=Q9CW42-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 184539354,
                "end_pos": 184519915,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000189492.2",
                        "url": "https://www.ensembl.org/id/ENSMUST00000189492.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000139716.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000139716.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "D3YZZ3-1",
            "url": "",
            "sequence": {
                "sequence": "MGAGSWALTLFGFSAFRVPGQPRSTWLGVAALGLAAVALGTVAWRRARPRRRRRLQQVGTVAQLWIYPIKSCKGLSVSEAECTAMGLRYGHLRDRFWLVINEEGNMVTARQEPRLVLISLTCEDDTLTLSAAYTKDLLLPITPPATNPLLQCRVHGLEIQGRDCGEDAAQWVSSFLKMQSCRLVHFEPHMRPRSSRQMKASGPISQNNEVAYSDASPFLVLSEASLEDLNSRLERRVKATNFRPNIVISGCGVYAEDSWNEVLIGDVELKRVMACTRCLLTTVDPDTGISDRKEPLETLKSYRLCDPSEQALYGKLPIFGQYFALENPGTIRVGDPVYLLGQ",
                "length": 342,
                "header": "tr|D3YZZ3-1|MARC1_MOUSE Computationally mapped isoform of Mitochondrial amidoxime-reducing component 1  OS=Mus musculus OX=10090 GN=Mtarc1 PE=1 SV=2 CANONICAL=Q9CW42-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 184543326,
                "end_pos": 184519915,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000110992.9",
                        "url": "https://www.ensembl.org/id/ENSMUST00000110992.9"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000106620.3",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000106620.3"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q9CW42-1",
            "url": "",
            "sequence": {
                "sequence": "MGAGSWALTLFGFSAFRVPGQPRSTWLGVAALGLAAVALGTVAWRRARPRRRRRLQQVGTVAQLWIYPIKSCKGLSVSEAECTAMGLRYGHLRDRFWLVINEEGNMVTARQEPRLVLISLTCEDDTLTLSAAYTKDLLLPITPPATNPLLQCRVHGLEIQGRDCGEDAAQWVSSFLKMQSCRLVHFEPHMRPRSSRQMKAVFRTKDQVAYSDASPFLVLSEASLEDLNSRLERRVKATNFRPNIVISGCGVYAEDSWNEVLIGDVELKRVMACTRCLLTTVDPDTGISDRKEPLETLKSYRLCDPSEQALYGKLPIFGQYFALENPGTIRVGDPVYLLGQ",
                "length": 340,
                "header": "sp|Q9CW42-1|MARC1_MOUSE Isoform 1 of Mitochondrial amidoxime-reducing component 1  OS=Mus musculus OX=10090 GN=Mtarc1 PE=1 SV=2 CANONICAL=Q9CW42-1"
            },
            "locus": {
                "chromosome": "1",
                "start_pos": 184543326,
                "end_pos": 184519915,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000048462",
                        "url": "https://www.ensembl.org/id/ENSMUST00000048462"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000035804",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000035804"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [
        "enzyme"
    ],
    "publication": [
        {
            "title": "Proteomic analysis of the mouse liver mitochondrial inner membrane.",
            "journal": "J. Biol. Chem.",
            "date": "2003",
            "authors": "Da Cruz S, Xenarios I, Langridge J, Vilbois F, Parone PA, Martinou JC",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9CW42",
                    "url": "https://www.uniprot.org/uniprot/Q9CW42"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "12865426",
                    "url": "https://glygen.org/publication/PubMed/12865426"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:66112",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:66112",
            "resource": "KEGG Pathway"
        },
        {
            "id": "R-MMU-211945",
            "name": "Phase I - Functionalization of compounds",
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-211945",
            "resource": "Reactome",
            "description": "Phase I - Functionalization of compounds"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "O88994-1",
            "protein_name": "Mitochondrial amidoxime reducing component 2",
            "gene_name": "Mtarc2",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MGSSSSTALARLGLPGQPRSTWLGVAALGLAAVALGTVAWRRARPRRRRQLQQVGTVSKVWIYPIKSCKGVSVCETECTDMGLRCGKVRDRFWMVVKEDGHMITARQEPRLVLVTITLENNYLMLEAPGMEPIVLPIKLPSSNKIHDCRLFGLDIKGRDCGDEVARWFTSYLKTQAYRLVQFDTKMKGRTTKKLYPSESYLQNYEVAYPDCSPIHLISEASLVDLNTRLQKKVKMEYFRPNIVVSGCEAFEEDTWDELLIGDVEMKRVLSCPRCVLTTVDPDTGIIDRKEPLETLKSYRLCDPSVKSLYQSSPLFGMYFSVEKIGSLRVGDPVYRMVD",
                "length": 338
            },
            "evidence": [
                {
                    "id": "45239917",
                    "url": "http://www.informatics.jax.org/homology/45239917",
                    "database": "MGI"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q5VT66-1",
            "protein_name": "Mitochondrial amidoxime-reducing component 1",
            "gene_name": "MTARC1",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MGAAGSSALARFVLLAQSRPGWLGVAALGLTAVALGAVAWRRAWPTRRRRLLQQVGTVAQLWIYPVKSCKGVPVSEAECTAMGLRSGNLRDRFWLVINQEGNMVTARQEPRLVLISLTCDGDTLTLSAAYTKDLLLPIKTPTTNAVHKCRVHGLEIEGRDCGEATAQWITSFLKSQPYRLVHFEPHMRPRRPHQIADLFRPKDQIAYSDTSPFLILSEASLADLNSRLEKKVKATNFRPNIVISGCDVYAEDSWDELLIGDVELKRVMACSRCILTTVDPDTGVMSRKEPLETLKSYRQCDPSERKLYGKSPLFGQYFVLENPGTIKVGDPVYLLGQ",
                "length": 337
            },
            "evidence": [
                {
                    "id": "45239917",
                    "url": "http://www.informatics.jax.org/homology/45239917",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Molecular Function",
                "total": 8,
                "go_terms": [
                    {
                        "name": "molybdenum ion binding",
                        "id": "GO:0030151",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030151",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9CW42",
                                "url": "https://www.uniprot.org/uniprot/Q9CW42"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nitrate reductase activity",
                        "id": "GO:0008940",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008940",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9CW42",
                                "url": "https://www.uniprot.org/uniprot/Q9CW42"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "pyridoxal phosphate binding",
                        "id": "GO:0030170",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030170",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9CW42",
                                "url": "https://www.uniprot.org/uniprot/Q9CW42"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "molybdopterin cofactor binding",
                        "id": "GO:0043546",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043546",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9CW42",
                                "url": "https://www.uniprot.org/uniprot/Q9CW42"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nitrite reductase (NO-forming) activity",
                        "id": "GO:0050421",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050421",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9CW42",
                                "url": "https://www.uniprot.org/uniprot/Q9CW42"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "catalytic activity",
                        "id": "GO:0003824",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003824",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9CW42",
                                "url": "https://www.uniprot.org/uniprot/Q9CW42"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "oxidoreductase activity, acting on other nitrogenous compounds as donors",
                        "id": "GO:0016661",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016661",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9CW42",
                                "url": "https://www.uniprot.org/uniprot/Q9CW42"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nitrite reductase activity",
                        "id": "GO:0098809",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098809",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9CW42",
                                "url": "https://www.uniprot.org/uniprot/Q9CW42"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Cellular Component",
                "total": 5,
                "go_terms": [
                    {
                        "name": "mitochondrion",
                        "id": "GO:0005739",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9CW42",
                                "url": "https://www.uniprot.org/uniprot/Q9CW42"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "membrane",
                        "id": "GO:0016020",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9CW42",
                                "url": "https://www.uniprot.org/uniprot/Q9CW42"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nitric-oxide synthase complex",
                        "id": "GO:1903958",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903958",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9CW42",
                                "url": "https://www.uniprot.org/uniprot/Q9CW42"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "mitochondrial outer membrane",
                        "id": "GO:0005741",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005741",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9CW42",
                                "url": "https://www.uniprot.org/uniprot/Q9CW42"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "mitochondrial inner membrane",
                        "id": "GO:0005743",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9CW42",
                                "url": "https://www.uniprot.org/uniprot/Q9CW42"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 3,
                "go_terms": [
                    {
                        "name": "nitric oxide biosynthetic process",
                        "id": "GO:0006809",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006809",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9CW42",
                                "url": "https://www.uniprot.org/uniprot/Q9CW42"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "nitrate metabolic process",
                        "id": "GO:0042126",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042126",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9CW42",
                                "url": "https://www.uniprot.org/uniprot/Q9CW42"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "cellular detoxification of nitrogen compound",
                        "id": "GO:0070458",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070458",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q9CW42",
                                "url": "https://www.uniprot.org/uniprot/Q9CW42"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [
        {
            "id": "61644",
            "name": "",
            "equation": "2 Fe(II)-[cytochrome b5] + 2 H(+) + N(omega)-hydroxy-L-arginine = 2 Fe(III)-[cytochrome b5] + H2O + L-arginine",
            "summary": "",
            "cellular_location": "",
            "input_participant_list": [],
            "output_participant_list": [],
            "enzyme_list": [
                "O88994-1",
                "A0A1W2Q693-1",
                "Q969Z3-1",
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                "Q922Q1-1",
                "Q9CW42-1"
            ],
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                    "id": "61644",
                    "database": "Rhea",
                    "url": "https://www.rhea-db.org/rhea/61644"
                }
            ]
        },
        {
            "id": "R-MMU-8936442",
            "name": "MARC1,MARC2 reduce N-hydroxylated compounds",
            "equation": "",
            "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>",
            "cellular_location": "cytosol, mitochondrial outer membrane",
            "input_participant_list": [
                "R-ALL-8936443"
            ],
            "output_participant_list": [],
            "enzyme_list": [
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                "Q922Q1-1",
                "Q9CW42-1"
            ],
            "evidence": [
                {
                    "id": "R-MMU-8936442",
                    "database": "Reactome",
                    "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8936442"
                }
            ]
        }
    ],
    "reaction_participants": [
        {
            "participant_id": "R-ALL-8936443",
            "participant_name": "NOHA [cytosol]",
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                    "id": "47823",
                    "database": "ChEBI",
                    "url": ""
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                    "id": "5227",
                    "database": "Guide to Pharmacology - Ligands",
                    "url": ""
                },
                {
                    "id": "47823",
                    "database": "ChEBI",
                    "url": ""
                },
                {
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                    "database": "Guide to Pharmacology - Ligands",
                    "url": ""
                },
                {
                    "id": "47823",
                    "database": "ChEBI",
                    "url": ""
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                {
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                    "database": "Guide to Pharmacology - Ligands",
                    "url": ""
                },
                {
                    "id": "47823",
                    "database": "ChEBI",
                    "url": ""
                },
                {
                    "id": "5227",
                    "database": "Guide to Pharmacology - Ligands",
                    "url": ""
                },
                {
                    "id": "5227",
                    "database": "Guide to Pharmacology - Ligands",
                    "url": ""
                },
                {
                    "id": "47823",
                    "database": "ChEBI",
                    "url": ""
                }
            ]
        }
    ],
    "reaction_enzymes": [
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            "uniprot_ac": "A0A1W2Q693",
            "gene_name": "Mocos",
            "activity": [
                {
                    "ec_number": "2.8.1.9",
                    "activity": "AH2 + L-cysteine + Mo-molybdopterin = A + H2O + L-alanine + thio-Mo-molybdopterin.",
                    "evidence": [
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                            "url": "https://www.uniprot.org/uniprot/A0A1W2Q693"
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                            "database": "UniProtKB",
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        {
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                            "url": "https://www.uniprot.org/uniprot/Q5VT66"
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                    ]
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            ]
        },
        {
            "uniprot_ac": "Q922Q1",
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                {
                    "ec_number": "1.7.-.-",
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            ]
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        {
            "uniprot_ac": "Q969Z3",
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                    "ec_number": "1.7.-.-",
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                    "evidence": [
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                            "id": "Q969Z3",
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                            "url": "https://www.uniprot.org/uniprot/Q969Z3"
                        }
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            "uniprot_ac": "Q9CW42",
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        {
            "uniprot_ac": "Q9DCN2",
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                {
                    "ec_number": "1.6.2.2",
                    "activity": "2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + H(+) + NAD(+).",
                    "evidence": [
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                            "database": "UniProtKB",
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                    "ec_number": "1.6.2.2",
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    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
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