{ "uniprot_canonical_ac": "Q9CUN6-1", "uniprot_ac": "Q9CUN6", "uniprot_id": "SMUF1_MOUSE", "mass": { "chemical_mass": 83356.0, "monoisotopic_mass": 83356.0 }, "refseq": { "ac": "XP_006504947", "name": "E3 ubiquitin-protein ligase SMURF1 isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006504947" }, "gene_names": [ { "name": "Smurf1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q9CUN6", "id": "Q9CUN6" }, { "name": "4930431E10Rik; mKIAA1625", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006504947", "id": "XP_006504947" }, { "name": "Smurf1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006504947", "id": "XP_006504947" } ], "protein_names": [ { "name": "E3 ubiquitin-protein ligase SMURF1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q9CUN6" }, { "name": "2.3.2.26", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9CUN6" }, { "name": "E3 ubiquitin-protein ligase SMURF1 isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033716", "id": "NP_001033716" }, { "name": "E3 ubiquitin-protein ligase SMURF1 isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083714", "id": "NP_083714" }, { "name": "E3 ubiquitin-protein ligase SMURF1 isoform X1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006504947", "id": "XP_006504947" }, { "name": "HECT-type E3 ubiquitin transferase SMURF1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9CUN6" }, { "name": "SMAD ubiquitination regulatory factor 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9CUN6" }, { "name": "SMAD-specific E3 ubiquitin-protein ligase 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9CUN6" }, { "name": "Smad ubiquitination regulatory factor 1; E3 ubiquitin-protein ligase SMURF1; HECT-type E3 ubiquitin transferase SMURF1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033716", "id": "NP_001033716" } ], "function": [ { "annotation": "Deletion of Smurf1 attenuates liver steatosis via stabilization of p53.", "evidence": [ { "database": "RefSeq", "id": "NP_083714", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083714" }, { "database": "PubMed", "id": "35672379", "url": "https://glygen.org/publication/PubMed/35672379" }, { "database": "RefSeq", "id": "NP_001033716", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033716" } ] }, { "annotation": "E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway (By similarity). Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway (By similarity). Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA (By similarity). Promotes ubiquitination and subsequent proteasomal degradation of MAVS (PubMed:23087404). Acts as an antagonist of TGF-beta signaling by ubiquitinating TGFBR1 and targeting it for degradation (By similarity). Plays a role in dendrite formation by melanocytes (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q9CUN6", "url": "https://www.uniprot.org/uniprot/Q9CUN6#function" }, { "database": "PubMed", "id": "23087404", "url": "https://glygen.org/publication/PubMed/23087404" }, { "database": "UniProtKB", "id": "Q9HCE7", "url": "https://www.uniprot.org/uniprot/Q9HCE7#function" } ] }, { "annotation": "HSP90beta chaperoning SMURF1-mediated LATS proteasomal degradation in the regulation of bone formation. Erratum:[Cell Signal. 2023 Oct;110:110810. PMID: 37481444]", "evidence": [ { "database": "RefSeq", "id": "NP_083714", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083714" }, { "database": "PubMed", "id": "36379376", "url": "https://glygen.org/publication/PubMed/36379376" }, { "database": "RefSeq", "id": "NP_001033716", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033716" } ] }, { "annotation": "Initial identification of Smurf1 as an ubiquitin ligase that inhibits BMP signaling by targeting Smad1/5 for proteasomal destruction in cultured cells and Xenopus embryos.", "evidence": [ { "database": "RefSeq", "id": "NP_083714", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083714" }, { "database": "PubMed", "id": "10458166", "url": "https://glygen.org/publication/PubMed/10458166" }, { "database": "RefSeq", "id": "NP_001033716", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033716" } ] }, { "annotation": "Smurf1 appears to be an important regulatory factor in osteoblast differentiation and a potential molecular target for identification of bone anabolic agents", "evidence": [ { "database": "RefSeq", "id": "NP_083714", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083714" }, { "database": "PubMed", "id": "12738770", "url": "https://glygen.org/publication/PubMed/12738770" }, { "database": "RefSeq", "id": "NP_001033716", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033716" } ] }, { "annotation": "Smurf1 regulates ameloblast polarization by ubiquitination-mediated degradation of RhoA.", "evidence": [ { "database": "RefSeq", "id": "NP_083714", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083714" }, { "database": "PubMed", "id": "36579844", "url": "https://glygen.org/publication/PubMed/36579844" }, { "database": "RefSeq", "id": "NP_001033716", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033716" } ] }, { "annotation": "The degradation of TGR5 mediated by Smurf1 contributes to diabetic nephropathy.", "evidence": [ { "database": "RefSeq", "id": "NP_083714", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083714" }, { "database": "PubMed", "id": "37481723", "url": "https://glygen.org/publication/PubMed/37481723" }, { "database": "RefSeq", "id": "NP_001033716", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033716" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q9CUN6", "url": "https://www.uniprot.org/uniprot/Q9CUN6" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Smurf1", "url": "https://www.uniprot.org/uniprot/Q9CUN6", "locus": { "chromosome": "5", "start_pos": 144813305, "end_pos": 144902657, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000038780", "url": "https://www.ensembl.org/id/ENSMUSG00000038780" } ] } } ], "crossref": [ { "id": "ENSMUSG00000038780", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000038780", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00078", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00078", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00201", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00201", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd08382", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08382", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "75788", "url": "https://www.ncbi.nlm.nih.gov/gene/75788", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q9CUN6", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q9CUN6*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000008", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000008", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000569", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000569", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001202", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001202", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024928", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024928", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035892", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035892", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR035983", "url": "https://www.ebi.ac.uk/interpro/entry/IPR035983", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036020", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036020", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:75788", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:75788", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1923038", "url": "http://www.informatics.jax.org/marker/MGI:1923038", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "QWDRPRH", "url": "https://omabrowser.org/oma/group/QWDRPRH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5480520at2759", "url": "http://www.orthodb.org/?query=5480520at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11254", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11254", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11254:SF293", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11254:SF293", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00168", "url": "http://pfam.xfam.org/family/PF00168", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00397", "url": "http://pfam.xfam.org/family/PF00397", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00632", "url": "http://pfam.xfam.org/family/PF00632", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q9CUN6", "url": "http://purl.obolibrary.org/obo/PR_Q9CUN6", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-201451", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-201451", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-2173791", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2173791", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-4608870", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-4608870", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-5632684", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5632684", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-8941858", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8941858", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983168", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001033716", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033716", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A0G2JEN5", "url": "https://www.uniprot.org/uniprot/A0A0G2JEN5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2JEN5-1", "url": "https://www.uniprot.org/uniprot/A0A0G2JEN5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9PYU8", "url": "https://www.uniprot.org/uniprot/E9PYU8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9PYU8-1", "url": "https://www.uniprot.org/uniprot/E9PYU8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9Q4K9", "url": "https://www.uniprot.org/uniprot/E9Q4K9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9Q4K9-1", "url": "https://www.uniprot.org/uniprot/E9Q4K9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9CUN6", "url": "https://www.uniprot.org/uniprot/Q9CUN6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9CUN6-1", "url": "https://www.uniprot.org/uniprot/Q9CUN6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCKLNPSDTDAVRGQIVVSLQTRDRIGGGGSVVDCRGLLENEGTVYEDSGPGRPLSCLMEEPAPYTDGTGAAAGGGNCRFVESPSQDQRLLVQRLRNPEVRGPLQTPQNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLQLPSEGSVEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYTLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE", "length": 731, "header": "sp|Q9CUN6-1|SMUF1_MOUSE Isoform 1 of E3 ubiquitin-protein ligase SMURF1 OS=Mus musculus OX=10090 GN=Smurf1 PE=1 SV=2 CANONICAL=Q9CUN6-1" }, "isoforms": [ { "isoform_ac": "A0A0G2JEN5-1", "url": "", "sequence": { "sequence": "XENEGTVYEDSGPGRPLSCLMEEPAPYTDGTGAAAGGGNCRFVESPSQDQRLLVQRLRNPEVRGPLQTPQNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSHQCQLKEPSQPLQLPSEGSVEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYTLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSL", "length": 309, "header": "tr|A0A0G2JEN5-1|A0A0G2JEN5_MOUSE Computationally mapped isoform of HECT-type E3 ubiquitin transferase OS=Mus musculus OX=10090 GN=Smurf1 PE=4 SV=4 CANONICAL=Q9CUN6-1" }, "locus": { "chromosome": "5", "start_pos": 144834804, "end_pos": 144821402, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000198621.2", "url": "https://www.ensembl.org/id/ENSMUST00000198621.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000142841.2", "url": "https://www.ensembl.org/id/ENSMUSP00000142841.2" } ] } }, { "isoform_ac": "E9PYU8-1", "url": "", "sequence": { "sequence": "MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCKLNPSDTDAVRGQIVVSLQTRDRIGGGGSVVDCRGLLENEGTVYEDSGPGRPLSCLMEEPAPYTDGTGAAAGGGNCRFVESPSQDQRLLVQRLRNPEVRGPLQTPQNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPLGTIPGGDEAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLQLPSEGSVEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYTLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE", "length": 757, "header": "tr|E9PYU8-1|SMUF1_MOUSE Computationally mapped isoform of E3 ubiquitin-protein ligase SMURF1 OS=Mus musculus OX=10090 GN=Smurf1 PE=1 SV=1 CANONICAL=Q9CUN6-1" }, "locus": { "chromosome": "5", "start_pos": 144902365, "end_pos": 144816170, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000110677.8", "url": "https://www.ensembl.org/id/ENSMUST00000110677.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000106305.2", "url": "https://www.ensembl.org/id/ENSMUSP00000106305.2" } ] } }, { "isoform_ac": "E9Q4K9-1", "url": "", "sequence": { "sequence": "MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCKLNPSDTDAVRGQIVVSLQTRDRIGGGGSVVDCRGLLENEGTVYEDSGPGRPLSCLMEEPAPYTDGTGAAAGGGNCRFVESPSQDQRLLVQRLRNPEVRGPLQTPQNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLQLPSEGSVEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYTLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE", "length": 728, "header": "tr|E9Q4K9-1|SMUF1_MOUSE Computationally mapped isoform of E3 ubiquitin-protein ligase SMURF1 OS=Mus musculus OX=10090 GN=Smurf1 PE=1 SV=1 CANONICAL=Q9CUN6-1" }, "locus": { "chromosome": "5", "start_pos": 144902365, "end_pos": 144816170, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000100461.7", "url": "https://www.ensembl.org/id/ENSMUST00000100461.7" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000098029.3", "url": "https://www.ensembl.org/id/ENSMUSP00000098029.3" } ] } }, { "isoform_ac": "Q9CUN6-1", "url": "", "sequence": { "sequence": "MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCKLNPSDTDAVRGQIVVSLQTRDRIGGGGSVVDCRGLLENEGTVYEDSGPGRPLSCLMEEPAPYTDGTGAAAGGGNCRFVESPSQDQRLLVQRLRNPEVRGPLQTPQNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLQLPSEGSVEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYTLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE", "length": 731, "header": "sp|Q9CUN6-1|SMUF1_MOUSE Isoform 1 of E3 ubiquitin-protein ligase SMURF1 OS=Mus musculus OX=10090 GN=Smurf1 PE=1 SV=2 CANONICAL=Q9CUN6-1" }, "locus": { "chromosome": "5", "start_pos": 144902365, "end_pos": 144816170, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000085684", "url": "https://www.ensembl.org/id/ENSMUST00000085684" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000082827", "url": "https://www.ensembl.org/id/ENSMUSP00000082827" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 148, "end_pos": 148, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "PRO", "id": "Q9CUN6", "url": "http://purl.obolibrary.org/obo/Q9CUN6" }, { "database": "iPTMnet", "id": "Q9CUN6", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9CUN6" }, { "database": "PubMed", "id": "27052174", "url": "https://glygen.org/publication/PubMed/27052174" } ], "site_lbl": "Ser148" }, { "start_pos": 200, "end_pos": 200, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9CUN6", "url": "https://www.uniprot.org/uniprot/Q9CUN6" } ], "site_lbl": "Ser200" }, { "start_pos": 672, "end_pos": 672, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q9CUN6", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9CUN6" }, { "database": "PubMed", "id": "31291647", "url": "https://glygen.org/publication/PubMed/31291647" } ], "site_lbl": "Ser672" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation.", "journal": "Nature", "date": "1999", "authors": "Zhu H, Kavsak P, Abdollah S, Wrana JL, Thomsen GH", "evidence": [ { "database": "RefSeq", "id": "NP_083714", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083714" }, { "database": "RefSeq", "id": "NP_001033716", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033716" } ], "reference": [ { "type": "PubMed", "id": "10458166", "url": "https://glygen.org/publication/PubMed/10458166" } ] }, { "title": "E3 ubiquitin ligase Smurf1 mediates core-binding factor alpha1/Runx2 degradation and plays a specific role in osteoblast differentiation.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Zhao M, Qiao M, Oyajobi BO, Mundy GR, Chen D", "evidence": [ { "database": "RefSeq", "id": "NP_001033716", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033716" }, { "database": "RefSeq", "id": "NP_083714", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083714" } ], "reference": [ { "type": "PubMed", "id": "12738770", "url": "https://glygen.org/publication/PubMed/12738770" } ] }, { "title": "Ndfip1 negatively regulates RIG-I-dependent immune signaling by enhancing E3 ligase Smurf1-mediated MAVS degradation.", "journal": "J. Immunol.", "date": "2012", "authors": "Wang Y, Tong X, Ye X", "evidence": [ { "database": "UniProtKB", "id": "Q9CUN6", "url": "https://www.uniprot.org/uniprot/Q9CUN6" } ], "reference": [ { "type": "PubMed", "id": "23087404", "url": "https://glygen.org/publication/PubMed/23087404" } ] }, { "title": "Smurf1 Inhibits Osteoblast Differentiation, Bone Formation, and Glucose Homeostasis through Serine 148.", "journal": "Cell reports", "date": "2016", "authors": "Shimazu J, Wei J, Karsenty G", "evidence": [ { "database": "iPTMnet", "id": "Q9CUN6", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9CUN6" } ], "reference": [ { "type": "PubMed", "id": "27052174", "url": "https://glygen.org/publication/PubMed/27052174" } ] }, { "title": "VprBP mitigates TGF-beta and Activin signaling by promoting Smurf1-mediated type I receptor degradation.", "journal": "Journal of molecular cell biology", "date": "2020", "authors": "Li Y, Cui C, Xie F, Kielbasa S, Mei H, van Dinther M, van Dam H, Bauer A, Zhang L, Ten Dijke P", "evidence": [ { "database": "iPTMnet", "id": "Q9CUN6", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9CUN6" } ], "reference": [ { "type": "PubMed", "id": "31291647", "url": "https://glygen.org/publication/PubMed/31291647" } ] }, { "title": "Deletion of Smurf1 attenuates liver steatosis via stabilization of p53.", "journal": "Laboratory investigation; a journal of technical methods and pathology", "date": "2022-10", "authors": "Lin Wenjun, Zhang Xin, Zhang Chuan, Li Li, Zhang Jing, Xie Ping, Zhan Yutao, An Wei", "evidence": [ { "database": "RefSeq", "id": "NP_083714", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083714" }, { "database": "RefSeq", "id": "NP_001033716", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033716" } ], "reference": [ { "type": "PubMed", "id": "35672379", "url": "https://glygen.org/publication/PubMed/35672379" } ] }, { "title": "HSP90\u03b2 chaperoning SMURF1-mediated LATS proteasomal degradation in the regulation of bone formation.", "journal": "Cellular signalling", "date": "2023-02", "authors": "Qu Meiyu, Gong Ying, Jin Yuyang, Gao Ruibo, He Qiangqiang, Xu Yana, Shen Tingyu, Mei Liu, Xu Chengyun, Hussain Musaddique, Barkat Muhammad Qasim, Wu Ximei", "evidence": [ { "database": "RefSeq", "id": "NP_001033716", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033716" }, { "database": "RefSeq", "id": "NP_083714", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083714" } ], "reference": [ { "type": "PubMed", "id": "36379376", "url": "https://glygen.org/publication/PubMed/36379376" } ] }, { "title": "Smurf1 regulates ameloblast polarization by ubiquitination-mediated degradation of RhoA.", "journal": "Cell proliferation", "date": "2022-12-29", "authors": "Niu Haoman, Bi Fei, Zhao Wenjun, Xu Yuchan, Han Qi, Guo Weihua, Chen Yu", "evidence": [ { "database": "RefSeq", "id": "NP_001033716", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033716" }, { "database": "RefSeq", "id": "NP_083714", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083714" } ], "reference": [ { "type": "PubMed", "id": "36579844", "url": "https://glygen.org/publication/PubMed/36579844" } ] }, { "title": "The degradation of TGR5 mediated by Smurf1 contributes to diabetic nephropathy.", "journal": "Cell reports", "date": "2023-08-29", "authors": "Lin Zeyuan, Li Shanshan, Xiao Haiming, Xu Zhanchi, Li Chuting, Zeng Jingran, Wang Shaogui, Liu Zhongqiu, Huang Heqing", "evidence": [ { "database": "RefSeq", "id": "NP_001033716", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033716" }, { "database": "RefSeq", "id": "NP_083714", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083714" } ], "reference": [ { "type": "PubMed", "id": "37481723", "url": "https://glygen.org/publication/PubMed/37481723" } ] } ], "pathway": [ { "id": "mmu:75788", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:75788", "resource": "KEGG Pathway" }, { "id": "R-MMU-201451", "name": "Signaling by BMP", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-201451", "resource": "Reactome", "description": "Signaling by BMP" }, { "id": "R-MMU-2173791", "name": "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2173791", "resource": "Reactome", "description": "TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)" }, { "id": "R-MMU-4608870", "name": "Asymmetric localization of PCP proteins", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-4608870", "resource": "Reactome", "description": "Asymmetric localization of PCP proteins" }, { "id": "R-MMU-5632684", "name": "Hedgehog 'on' state", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5632684", "resource": "Reactome", "description": "Hedgehog 'on' state" }, { "id": "R-MMU-8941858", "name": "Regulation of RUNX3 expression and activity", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8941858", "resource": "Reactome", "description": "Regulation of RUNX3 expression and activity" }, { "id": "R-MMU-983168", "name": "Antigen processing: Ubiquitination & Proteasome degradation", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983168", "resource": "Reactome", "description": "Antigen processing: Ubiquitination & Proteasome degradation" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K612-1", "protein_name": "E3 ubiquitin-protein ligase", "gene_name": "Smurf1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": 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"common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 20, "go_terms": [ { "name": "positive regulation of dendrite extension", "id": "GO:1903861", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903861", "evidence": [ { "database": "UniProtKB", "id": "Q9CUN6", "url": "https://www.uniprot.org/uniprot/Q9CUN6" } ], "pmid": "" }, { "name": "ubiquitin-dependent SMAD protein catabolic process", "id": "GO:0030579", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030579", "evidence": [ { "database": "UniProtKB", "id": "Q9CUN6", "url": "https://www.uniprot.org/uniprot/Q9CUN6" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "Q9CUN6", "url": "https://www.uniprot.org/uniprot/Q9CUN6" } ], "pmid": "" }, { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "Q9CUN6", "url": "https://www.uniprot.org/uniprot/Q9CUN6" } ], "pmid": "" }, { "name": "BMP signaling pathway", "id": "GO:0030509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030509", "evidence": [ { "database": "UniProtKB", "id": "Q9CUN6", "url": "https://www.uniprot.org/uniprot/Q9CUN6" } ], "pmid": "" }, { "name": "negative regulation of BMP signaling pathway", "id": "GO:0030514", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030514", "evidence": [ { "database": "UniProtKB", "id": "Q9CUN6", "url": "https://www.uniprot.org/uniprot/Q9CUN6" } ], "pmid": "" }, { "name": "positive regulation of axon extension", "id": "GO:0045773", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045773", "evidence": [ { "database": "UniProtKB", "id": "Q9CUN6", "url": "https://www.uniprot.org/uniprot/Q9CUN6" } ], "pmid": "" }, { "name": "protein polyubiquitination", "id": "GO:0000209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000209", "evidence": [ { "database": "UniProtKB", "id": "Q9CUN6", "url": "https://www.uniprot.org/uniprot/Q9CUN6" } ], "pmid": "" }, { "name": "negative regulation of transforming growth factor beta receptor signaling pathway", "id": "GO:0030512", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030512", "evidence": [ { "database": "UniProtKB", "id": "Q9CUN6", "url": "https://www.uniprot.org/uniprot/Q9CUN6" } ], "pmid": "" }, { "name": "protein localization to cell surface", "id": "GO:0034394", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034394", "evidence": [ { "database": "UniProtKB", "id": "Q9CUN6", "url": "https://www.uniprot.org/uniprot/Q9CUN6" } ], "pmid": "" }, { "name": "protein export from nucleus", "id": "GO:0006611", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006611", "evidence": [ { "database": "UniProtKB", "id": "Q9CUN6", "url": "https://www.uniprot.org/uniprot/Q9CUN6" } ], "pmid": "" }, { "name": "engulfment of target by autophagosome", "id": "GO:0061736", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061736", "evidence": [ { "database": "UniProtKB", "id": "Q9CUN6", "url": "https://www.uniprot.org/uniprot/Q9CUN6" } ], "pmid": "" }, { "name": "substrate localization to autophagosome", "id": "GO:0061753", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061753", "evidence": [ { "database": "UniProtKB", "id": "Q9CUN6", "url": "https://www.uniprot.org/uniprot/Q9CUN6" } ], "pmid": "" }, { "name": "protein targeting to vacuole involved in autophagy", "id": "GO:0071211", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071211", "evidence": [ { "database": "UniProtKB", "id": "Q9CUN6", "url": "https://www.uniprot.org/uniprot/Q9CUN6" } ], "pmid": "" }, { "name": "receptor catabolic process", "id": "GO:0032801", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032801", "evidence": [ { "database": "UniProtKB", "id": "Q9CUN6", "url": "https://www.uniprot.org/uniprot/Q9CUN6" } ], "pmid": "" }, { "name": "positive regulation of ubiquitin-dependent protein catabolic process", "id": "GO:2000060", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000060", "evidence": [ { "database": "UniProtKB", "id": "Q9CUN6", "url": "https://www.uniprot.org/uniprot/Q9CUN6" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "Q9CUN6", "url": "https://www.uniprot.org/uniprot/Q9CUN6" } ], "pmid": "" }, { "name": "ubiquitin-dependent protein catabolic process", "id": "GO:0006511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006511", "evidence": [ { "database": "UniProtKB", "id": "Q9CUN6", "url": "https://www.uniprot.org/uniprot/Q9CUN6" } ], "pmid": "" }, { "name": "negative regulation of ossification", "id": "GO:0030279", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030279", "evidence": [ { "database": "UniProtKB", "id": "Q9CUN6", "url": "https://www.uniprot.org/uniprot/Q9CUN6" } ], "pmid": "" }, { "name": "parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization", "id": "GO:0061734", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061734", "evidence": [ { "database": "UniProtKB", "id": "Q9CUN6", "url": "https://www.uniprot.org/uniprot/Q9CUN6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q9CUN6", "url": "https://www.uniprot.org/uniprot/Q9CUN6" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q9CUN6", "url": "https://www.uniprot.org/uniprot/Q9CUN6" } ], "pmid": "" }, { "name": "axon", "id": "GO:0030424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424", "evidence": [ { "database": "UniProtKB", "id": "Q9CUN6", "url": "https://www.uniprot.org/uniprot/Q9CUN6" } ], "pmid": "" }, { "name": "neuronal cell body", "id": "GO:0043025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "evidence": [ { "database": "UniProtKB", "id": "Q9CUN6", "url": "https://www.uniprot.org/uniprot/Q9CUN6" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q9CUN6", "url": "https://www.uniprot.org/uniprot/Q9CUN6" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q9CUN6", "url": "https://www.uniprot.org/uniprot/Q9CUN6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "ubiquitin protein ligase activity", "id": "GO:0061630", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061630", "evidence": [ { "database": "UniProtKB", "id": "Q9CUN6", "url": "https://www.uniprot.org/uniprot/Q9CUN6" } ], "pmid": "" }, { "name": "R-SMAD binding", "id": "GO:0070412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070412", "evidence": [ { "database": "UniProtKB", "id": "Q9CUN6", "url": "https://www.uniprot.org/uniprot/Q9CUN6" } ], "pmid": "" }, { "name": "I-SMAD binding", "id": "GO:0070411", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070411", "evidence": [ { "database": "UniProtKB", "id": "Q9CUN6", "url": "https://www.uniprot.org/uniprot/Q9CUN6" } ], "pmid": "" }, { "name": "ubiquitin-protein transferase activity", "id": "GO:0004842", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004842", "evidence": [ { "database": "UniProtKB", "id": "Q9CUN6", "url": "https://www.uniprot.org/uniprot/Q9CUN6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 303, "end_pos": 305, "annotation": "n_glycosylation_sequon" }, { "start_pos": 9, "end_pos": 11, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Auto-ubiquitinated in presence of NDFIP1. Ubiquitinated by the SCF(FBXL15) complex at Lys-355 and Lys-357, leading to its degradation by the proteasome. Lys-357 is the primary ubiquitination site.", "evidence": [ { "database": "UniProtKB", "id": "Q9CUN6", "url": "https://www.uniprot.org/uniprot/Q9CUN6" }, { "database": "PubMed", "id": "Q9HCE7", "url": "https://glygen.org/publication/PubMed/Q9HCE7" } ] } ], "interactions": [], "reactions": [ { "id": "R-MMU-201445", "name": "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A2A5Z6-1", "Q9CUN6-1" ], "evidence": [ { "id": "R-MMU-201445", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-201445" } ] }, { "id": "R-MMU-201821", "name": "I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytoplasmic side of plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P27040-1", "A2A5Z6-1", "P36898-1", "P27038-1", "P36895-1", "O35607-1", "Q9CUN6-1" ], "evidence": [ { "id": "R-MMU-201821", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-201821" } ] }, { "id": "R-MMU-2160931", "name": "Disassembly of tight junctions", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cell junction", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9QUI0-1", "Q64729-1", "Q62312-2", "Q02956-1", "Q9CUN6-1" ], "evidence": [ { "id": "R-MMU-2160931", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2160931" } ] }, { "id": "R-MMU-2160932", "name": "SMURF1 binds phosphorylated PARD6A", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cell junction, cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9QUI0-1", "Q64729-1", "Q62312-2", "Q02956-1", "Q9CUN6-1" ], "evidence": [ { "id": "R-MMU-2160932", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2160932" } ] }, { "id": "R-MMU-2160935", "name": "SMURF1 ubiquitinates RHOA", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cell junction, cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9QUI0-1", "Q64729-1", "Q62312-2", "Q02956-1", "Q9CUN6-1" ], "evidence": [ { "id": "R-MMU-2160935", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2160935" } ] }, { "id": "R-MMU-4608852", "name": "SMURF1/2 ubiquitinates PRICKLE1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [ "R-MMU-4608816" ], "output_participant_list": [ "R-MMU-4608820" ], "enzyme_list": [ "A2A5Z6-1", "Q9CUN6-1" ], "evidence": [ { "id": "R-MMU-4608852", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-4608852" } ] }, { "id": "R-MMU-4608854", "name": "SMURF1/2 are recruited to the DVL2:PARD6A complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A2A5Z6-1", "Q9CUN6-1" ], "evidence": [ { "id": "R-MMU-4608854", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-4608854" } ] }, { "id": "R-MMU-5632642", "name": "Smurf1/2 bind Ptch1", "equation": "", "summary": "Smurf1 and Smurf2 bind to Ptch1 in a manner that depends on the 2 C-terminal Ptch1 PPXY motifs (Yue et al, 2014)", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A2A5Z6-1", "Q9CUN6-1" ], "evidence": [ { "id": "R-MMU-5632642", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5632642" } ] }, { "id": "R-MMU-5632644", "name": "Smurf1/2 ubiquitinates Ptch1", "equation": "", "summary": "Mouse Ptch1 is ubiquitinated on its C-terminal tail in a Smurf1/2-dependent manner. Smurf1/2-mediated ubiquitination is stimulated by SHH and results in downregulation of Ptch1 from the ciliary membrane to endocytic compartments for degradation (Yue et al, 2014).", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A2A5Z6-1", "Q9CUN6-1" ], "evidence": [ { "id": "R-MMU-5632644", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5632644" } ] }, { "id": "R-MMU-5635865", "name": "SMURF1/2 dissociates from ub-PTCH1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "ciliary membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A2A5Z6-1", "Q9CUN6-1" ], "evidence": [ { "id": "R-MMU-5635865", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5635865" } ] }, { "id": "R-MMU-8952419", "name": "SMURFs ubiquitinate RUNX3", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-MMU-8865393" ], "output_participant_list": [ "R-MMU-8952417" ], "enzyme_list": [ "B2RWS6-1", "A2A5Z6-1", "Q9CUN6-1" ], "evidence": [ { "id": "R-MMU-8952419", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8952419" } ] }, { "id": "R-MMU-9009434", "name": "Runx2 binds Smurf1", "equation": "", "summary": "Recombinant mouse Smurf1 binds recombinant mouse Runx2 (Zhao et al. 2003).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9CUN6-1" ], "evidence": [ { "id": "R-MMU-9009434", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9009434" } ] }, { "id": "R-MMU-9009440", "name": "Smurf1 polyubiquitinates Runx2", "equation": "", "summary": "Recombinant mouse Smurf1 polyubiquitinates recombinant mouse Runx2 (Zhao et al. 2003).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9CUN6-1" ], "evidence": [ { "id": "R-MMU-9009440", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9009440" } ] }, { "id": "R-MMU-983140", "name": "Transfer of Ub from E2 to substrate and release of E2", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8CFI0-1", "Q6P073-1", "Q8CFI2-1", "Q91W82-1", "Q921J4-1", "Q922B6-1", "Q99PQ2-1", "Q9WUD1-1", "Q9WUB0-1", "Q8BM54-1", "Q8C432-1", "Q9DBU5-1", "Q9ET26-1", "Q9JI90-1", "Q7TMY8-1", "Q1PSW8-1", "Q8R516-1", "Q9D074-1", "O55176-3", "Q8BH75-1", "Q99KR6-1", "Q9D0C1-1", "Q9WTV7-1", "G5E870-1", "Q80WG7-1", "Q80X56-1", "Q8CH72-1", "Q3UE37-1", "Q8CCJ3-3", "Q8VDW4-1", "Q06986-1", "P60605-1", "Q3U487-1", "P97868-1", "Q5XPI3-1", "Q6PDX6-1", "Q91YL2-1", "A2A5Z6-1", "Q925F4-1", "Q99ML9-1", "Q9JIY2-1", "Q69ZI1-1", "O08759-1", "P62257-1", "Q6WKZ8-1", "Q6ZPJ3-1", "A2AN08-1", "Q71FD5-1", "Q8CHG5-1", "P61092-1", "Q3UIR3-1", "Q6I6G8-1", "Q05A36-1", "Q9QXP6-1", "A2A7Q9-1", "E9Q555-1", "P50636-1", "Q9QZR0-1", "Q9QZS2-1", "P61089-1", "Q38HM4-1", "Q9ESN2-1", "Q5FWH2-3", "Q8BX13-1", "O70481-1", "P52482-1", "P61080-1", "P61087-1", "P62254-1", "P62838-1", "P63147-1", "P68037-1", "Q6ZWZ2-1", "Q80U95-1", "Q8K2Z8-1", "Q9CY34-1", "Q9D1C1-1", "Q9ES34-1", "Q9JJZ4-1", "Q9QZU9-1", "Q9Z255-1", "Q91V17-1", "Q9CR50-1", "Q3TTA7-1", "Q80TR8-1", "O70263-1", "Q80U04-1", "Q80ZI6-1", "D3YYI7-1", "Q9CQE0-1", "Q8C863-1", "Q9WVS6-1", "Q62191-1", "Q7TPV2-1", "Q3U0D9-1", "Q4U2R1-1", "P46935-1", "F2Z461-1", "P62878-1", "Q8BKD6-1", "Q9CUN6-1", "Q8BZZ3-1", "Q69ZR2-1", "Q6PAV2-1", "Q8CDU6-1", "Q8C7M3-1", "Q8VIG6-1", "E9Q735-1", "P52483-1", "P61079-1", "P61082-1", "Q7TSS2-1", "Q9Z1K6-1", "Q8VEM1-1", "Q6A009-1", "Q5NCC3-1", "Q6PCX9-1", "Q810I2-1", "Q9DBK7-1" ], "evidence": [ { "id": "R-MMU-983140", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983140" } ] }, { "id": "R-MMU-983147", "name": "Release of E3 from polyubiquitinated substrate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8CFI0-1", "Q922B6-1", "Q99PQ2-1", "Q9WUD1-1", "Q9WUB0-1", "Q8BM54-1", "Q8C432-1", "Q9DBU5-1", "Q9ET26-1", "Q9JI90-1", "Q7TMY8-1", "Q1PSW8-1", "Q8R516-1", "Q9D074-1", "O55176-3", "Q8BH75-1", "Q99KR6-1", "Q9D0C1-1", "Q9WTV7-1", "G5E870-1", "Q80WG7-1", "Q80X56-1", "Q8CH72-1", "Q8CCJ3-3", "Q06986-1", "Q3U487-1", "P97868-1", "Q5XPI3-1", "Q6PDX6-1", "Q91YL2-1", "A2A5Z6-1", "Q925F4-1", "Q99ML9-1", "Q9JIY2-1", "Q69ZI1-1", "O08759-1", "Q6WKZ8-1", "A2AN08-1", "Q71FD5-1", "Q8CHG5-1", "P61092-1", "Q3UIR3-1", "Q6I6G8-1", "Q05A36-1", "Q9QXP6-1", "A2A7Q9-1", "E9Q555-1", "P50636-1", "Q9QZR0-1", "Q9QZS2-1", "Q38HM4-1", "Q9ESN2-1", "Q5FWH2-3", "Q8BX13-1", "O70481-1", "Q80U95-1", "Q9ES34-1", "Q91V17-1", "Q9CR50-1", "Q3TTA7-1", "Q80TR8-1", "O70263-1", "Q80U04-1", "Q80ZI6-1", "D3YYI7-1", "Q9CQE0-1", "Q8C863-1", "Q9WVS6-1", "Q62191-1", "Q7TPV2-1", "Q3U0D9-1", "Q4U2R1-1", "P46935-1", "F2Z461-1", "P62878-1", "Q8BKD6-1", "Q9CUN6-1", "Q8BZZ3-1", "Q69ZR2-1", "Q6PAV2-1", "Q8CDU6-1", "Q8C7M3-1", "Q8VIG6-1", "E9Q735-1", "Q9Z1K6-1", "Q8VEM1-1", "Q6A009-1", "Q5NCC3-1", "Q6PCX9-1", "Q810I2-1" ], "evidence": [ { "id": "R-MMU-983147", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983147" } ] }, { "id": "R-MMU-983156", "name": "Polyubiquitination of substrate", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8CFI0-1", "Q6P073-1", "Q8CFI2-1", "Q91W82-1", "Q921J4-1", "Q922B6-1", "Q99PQ2-1", "Q9WUD1-1", "Q9WUB0-1", "Q8BM54-1", "Q8C432-1", "Q9DBU5-1", "Q9ET26-1", "Q9JI90-1", "Q7TMY8-1", "Q1PSW8-1", "Q8R516-1", "Q9D074-1", "O55176-3", "Q8BH75-1", "Q99KR6-1", "Q9D0C1-1", "Q9WTV7-1", "G5E870-1", "Q80WG7-1", "Q80X56-1", "Q8CH72-1", "Q3UE37-1", "Q8CCJ3-3", "Q8VDW4-1", "Q06986-1", "P60605-1", "Q3U487-1", "P97868-1", "Q5XPI3-1", "Q6PDX6-1", "Q91YL2-1", "A2A5Z6-1", "Q925F4-1", "Q99ML9-1", "Q9JIY2-1", "Q69ZI1-1", "O08759-1", "P62257-1", "Q6WKZ8-1", "Q6ZPJ3-1", "A2AN08-1", "Q71FD5-1", "Q8CHG5-1", "P61092-1", "Q3UIR3-1", "Q6I6G8-1", "Q05A36-1", "Q9QXP6-1", "A2A7Q9-1", "E9Q555-1", "P50636-1", "Q9QZR0-1", "Q9QZS2-1", "P61089-1", "Q38HM4-1", "Q9ESN2-1", "Q5FWH2-3", "Q8BX13-1", "O70481-1", "P52482-1", "P61080-1", "P61087-1", "P62254-1", "P62838-1", "P63147-1", "P68037-1", "Q6ZWZ2-1", "Q80U95-1", "Q8K2Z8-1", "Q9CY34-1", "Q9D1C1-1", "Q9ES34-1", "Q9JJZ4-1", "Q9QZU9-1", "Q9Z255-1", "Q91V17-1", "Q9CR50-1", "Q3TTA7-1", "Q80TR8-1", "O70263-1", "Q80U04-1", "Q80ZI6-1", "D3YYI7-1", "Q9CQE0-1", "Q8C863-1", "Q9WVS6-1", "Q62191-1", "Q7TPV2-1", "Q3U0D9-1", "Q4U2R1-1", "P46935-1", "F2Z461-1", "P62878-1", "Q8BKD6-1", "Q9CUN6-1", "Q8BZZ3-1", "Q69ZR2-1", "Q6PAV2-1", "Q8CDU6-1", "Q8C7M3-1", "Q8VIG6-1", "E9Q735-1", "P52483-1", "P61079-1", "P61082-1", "Q7TSS2-1", "Q9Z1K6-1", "Q8VEM1-1", "Q6A009-1", "Q5NCC3-1", "Q6PCX9-1", "Q810I2-1", "Q9DBK7-1" ], "evidence": [ { "id": "R-MMU-983156", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983156" } ] }, { "id": "R-MMU-983157", "name": "Interaction of E3 with substrate and E2-Ub complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8CFI0-1", "Q6P073-1", "Q8CFI2-1", "Q91W82-1", "Q921J4-1", "Q922B6-1", "Q99PQ2-1", "Q9WUD1-1", "Q9WUB0-1", "Q8BM54-1", "Q8C432-1", "Q9DBU5-1", "Q9ET26-1", "Q9JI90-1", "Q7TMY8-1", "Q1PSW8-1", "Q8R516-1", "Q9D074-1", "O55176-3", "Q8BH75-1", "Q99KR6-1", "Q9D0C1-1", "Q9WTV7-1", "G5E870-1", "Q80WG7-1", "Q80X56-1", "Q8CH72-1", "Q3UE37-1", "Q8CCJ3-3", "Q8VDW4-1", "Q06986-1", "P60605-1", "Q3U487-1", "P97868-1", "Q5XPI3-1", "Q6PDX6-1", "Q91YL2-1", "A2A5Z6-1", "Q925F4-1", "Q99ML9-1", "Q9JIY2-1", "Q69ZI1-1", "O08759-1", "P62257-1", "Q6WKZ8-1", "Q6ZPJ3-1", "A2AN08-1", "Q71FD5-1", "Q8CHG5-1", "P61092-1", "Q3UIR3-1", "Q6I6G8-1", "Q05A36-1", "Q9QXP6-1", "A2A7Q9-1", "E9Q555-1", "P50636-1", "Q9QZR0-1", "Q9QZS2-1", "P61089-1", "Q38HM4-1", "Q9ESN2-1", "Q5FWH2-3", "Q8BX13-1", "O70481-1", "P52482-1", "P61080-1", "P61087-1", "P62254-1", "P62838-1", "P63147-1", "P68037-1", "Q6ZWZ2-1", "Q80U95-1", "Q8K2Z8-1", "Q9CY34-1", "Q9D1C1-1", "Q9ES34-1", "Q9JJZ4-1", "Q9QZU9-1", "Q9Z255-1", "Q91V17-1", "Q9CR50-1", "Q3TTA7-1", "Q80TR8-1", "O70263-1", "Q80U04-1", "Q80ZI6-1", "D3YYI7-1", "Q9CQE0-1", "Q8C863-1", "Q9WVS6-1", "Q62191-1", "Q7TPV2-1", "Q3U0D9-1", "Q4U2R1-1", "P46935-1", "F2Z461-1", "P62878-1", "Q8BKD6-1", "Q9CUN6-1", "Q8BZZ3-1", "Q69ZR2-1", "Q6PAV2-1", "Q8CDU6-1", "Q8C7M3-1", "Q8VIG6-1", "E9Q735-1", "P52483-1", "P61079-1", "P61082-1", "Q7TSS2-1", "Q9Z1K6-1", "Q8VEM1-1", "Q6A009-1", "Q5NCC3-1", "Q6PCX9-1", "Q810I2-1", "Q9DBK7-1" ], "evidence": [ { "id": "R-MMU-983157", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983157" } ] } ], "reaction_participants": [ { "participant_id": "R-MMU-4608816", "participant_name": "Prickle1 [cytosol]", "crossref": [ { "id": "ENSMUST00000109255", "database": "Ensembl", "url": "" }, { "id": "XP_006520328.1", "database": "RefSeq", "url": "" }, { "id": "ENSMUSP00000104878", "database": "Ensembl", "url": "" }, { "id": "ENSMUSP00000049204", "database": "Ensembl", "url": "" }, { "id": "NP_001028389.1", "database": "RefSeq", "url": "" }, { "id": "ENSMUST00000048982", "database": "Ensembl", "url": "" }, { "id": "Q3U5C7", "database": "UniProt", "url": "" }, { "id": "Q3U5C7", "database": "PRO", "url": "" }, { "id": "XP_006520327.1", "database": "RefSeq", "url": "" }, { "id": "1916034", "database": "MGI", "url": "" }, { "id": "ENSMUSG00000036158", "database": "Ensembl", "url": "" }, { "id": "XP_006520329.1", "database": "RefSeq", "url": "" } ] }, { "participant_id": "R-MMU-4608820", "participant_name": "Prickle1 [cytosol]", "crossref": [ { "id": "Q3U5C7", "database": "UniProt", "url": "" }, { "id": "XP_006520328.1", "database": "RefSeq", "url": "" }, { "id": "XP_006520327.1", "database": "RefSeq", "url": "" }, { "id": "NP_001028389.1", "database": "RefSeq", "url": "" }, { "id": "XP_006520329.1", "database": "RefSeq", "url": "" }, { "id": "ENSMUST00000109255", "database": "Ensembl", "url": "" }, { "id": "Q3U5C7", "database": "PRO", "url": "" }, { "id": "ENSMUST00000048982", "database": "Ensembl", "url": "" }, { "id": "ENSMUSG00000036158", "database": "Ensembl", "url": "" }, { "id": "ENSMUSP00000104878", "database": "Ensembl", "url": "" }, { "id": "1916034", "database": "MGI", "url": "" }, { "id": "ENSMUSP00000049204", "database": "Ensembl", "url": "" } ] }, { "participant_id": "R-MMU-8865393", "participant_name": "Runx3 [nucleoplasm]", "crossref": [ { "id": "HMDBP14475", "database": "HMDB Protein", "url": "" }, { "id": "ENSMUSG00000070691", "database": "Ensembl", "url": "" }, { "id": "ENSMUSP00000113159", "database": "Ensembl", "url": "" }, { "id": "102672", "database": "MGI", "url": "" }, { "id": "ENSMUST00000119564", "database": "Ensembl", "url": "" }, { "id": "Q64131", "database": "UniProt", "url": "" }, { "id": "Q64131", "database": "PRO", "url": "" } ] }, { "participant_id": "R-MMU-8952417", "participant_name": "Runx3 [nucleoplasm]", "crossref": [ { "id": "Q64131", "database": "UniProt", "url": "" }, { "id": "ENSMUSG00000070691", "database": "Ensembl", "url": "" }, { "id": "ENSMUST00000119564", "database": "Ensembl", "url": "" }, { "id": "ENSMUSP00000113159", "database": "Ensembl", "url": "" }, { "id": "Q64131", "database": "PRO", "url": "" }, { "id": "HMDBP14475", "database": "HMDB Protein", "url": "" }, { "id": "102672", "database": "MGI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A2A5Z6", "gene_name": "Smurf2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A2A5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2A5Z6" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "A2A5Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2A5Z6" } ] } ] }, { "uniprot_ac": "A2A7Q9", "gene_name": "Rnf19b", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "A2A7Q9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2A7Q9" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "A2A7Q9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2A7Q9" } ] } ] }, { "uniprot_ac": "A2AN08", "gene_name": "Ubr4", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "A2AN08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AN08" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "A2AN08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AN08" } ] } ] }, { "uniprot_ac": "B2RWS6", "gene_name": "Ep300", "activity": [ { "ec_number": "2.3.1.48", "activity": "acetyl-CoA + L-lysyl-[histone] = CoA + H(+) + N(6)-acetyl-L-lysyl-[histone].", "evidence": [ { "id": "B2RWS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RWS6" } ] }, { "ec_number": "2.3.1.48", "activity": "", "evidence": [ { "id": "B2RWS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RWS6" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "B2RWS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RWS6" } ] } ] }, { "uniprot_ac": "D3YYI7", "gene_name": "Rnf217", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "D3YYI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3YYI7" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "D3YYI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3YYI7" } ] } ] }, { "uniprot_ac": "E9Q555", "gene_name": "Rnf213", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "E9Q555", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q555" } ] }, { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E9Q555", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q555" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E9Q555", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q555" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E9Q555", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q555" } ] } ] }, { "uniprot_ac": "E9Q735", "gene_name": "Ube4a", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E9Q735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q735" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E9Q735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q735" } ] } ] }, { "uniprot_ac": "F2Z461", "gene_name": "Herc6", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "F2Z461", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F2Z461" } ] } ] }, { "uniprot_ac": "G5E870", "gene_name": "Trip12", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "G5E870", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G5E870" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "G5E870", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G5E870" } ] } ] }, { "uniprot_ac": "O08759", "gene_name": "Ube3a", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O08759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08759" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "O08759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08759" } ] } ] }, { "uniprot_ac": "O35607", "gene_name": "Bmpr2", "activity": [ { "ec_number": "2.7.11.30", "activity": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein].", "evidence": [ { "id": "O35607", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35607" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "O35607", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35607" } ] } ] }, { "uniprot_ac": "O55176", "gene_name": "Pja1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O55176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55176" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "O55176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55176" } ] } ] }, { "uniprot_ac": "O70263", "gene_name": "Lnx1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O70263", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70263" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "O70263", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70263" } ] } ] }, { "uniprot_ac": "O70481", "gene_name": "Ubr1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O70481", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70481" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "O70481", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70481" } ] } ] }, { "uniprot_ac": "P27038", "gene_name": "Acvr2a", "activity": [ { "ec_number": "2.7.11.30", "activity": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein].", "evidence": [ { "id": "P27038", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27038" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "P27038", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27038" } ] } ] }, { "uniprot_ac": "P27040", "gene_name": "Acvr2b", "activity": [ { "ec_number": "2.7.11.30", "activity": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein].", "evidence": [ { "id": "P27040", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27040" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "P27040", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27040" } ] } ] }, { "uniprot_ac": "P36895", "gene_name": "Bmpr1a", "activity": [ { "ec_number": "2.7.11.30", "activity": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein].", "evidence": [ { "id": "P36895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36895" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "P36895", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36895" } ] } ] }, { "uniprot_ac": "P36898", "gene_name": "Bmpr1b", "activity": [ { "ec_number": "2.7.11.30", "activity": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein].", "evidence": [ { "id": "P36898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36898" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "P36898", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36898" } ] } ] }, { "uniprot_ac": "P46935", "gene_name": "Nedd4", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P46935", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46935" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "P46935", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46935" } ] } ] }, { "uniprot_ac": "P50636", "gene_name": "Rnf19a", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "P50636", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50636" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "P50636", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50636" } ] } ] }, { "uniprot_ac": "P52482", "gene_name": "Ube2e1", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P52482", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52482" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P52482", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52482" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P52482", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52482" } ] } ] }, { "uniprot_ac": "P52483", "gene_name": "Ube2e3", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P52483", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52483" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P52483", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52483" } ] } ] }, { "uniprot_ac": "P60605", "gene_name": "Ube2g2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P60605", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60605" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P60605", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60605" } ] } ] }, { "uniprot_ac": "P61079", "gene_name": "Ube2d3", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P61079", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61079" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P61079", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61079" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P61079", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61079" } ] } ] }, { "uniprot_ac": "P61080", "gene_name": "Ube2d1", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P61080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61080" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P61080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61080" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P61080", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61080" } ] } ] }, { "uniprot_ac": "P61082", "gene_name": "Ube2m", "activity": [ { "ec_number": "2.3.2.34", "activity": "[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.", "evidence": [ { "id": "P61082", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61082" } ] }, { "ec_number": "2.3.2.34", "activity": "", "evidence": [ { "id": "P61082", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61082" } ] } ] }, { "uniprot_ac": "P61087", "gene_name": "Ube2k", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P61087", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61087" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P61087", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61087" } ] } ] }, { "uniprot_ac": "P61089", "gene_name": "Ube2n", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P61089", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61089" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P61089", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61089" } ] } ] }, { "uniprot_ac": "P61092", "gene_name": "Siah1a", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P61092", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61092" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "P61092", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61092" } ] } ] }, { "uniprot_ac": "P62254", "gene_name": "Ube2g1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P62254", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62254" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P62254", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62254" } ] } ] }, { "uniprot_ac": "P62257", "gene_name": "Ube2h", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P62257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62257" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P62257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62257" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P62257", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62257" } ] } ] }, { "uniprot_ac": "P62838", "gene_name": "Ube2d2", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P62838", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62838" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P62838", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62838" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P62838", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62838" } ] } ] }, { "uniprot_ac": "P62878", "gene_name": "Rbx1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P62878", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62878" } ] }, { "ec_number": "2.3.2.32", "activity": "S-[NEDD8-protein]-yl-[E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin]-L-lysine = [E2 NEDD8-conjugating enzyme]-L-cysteine + N(6)-[NEDD8-protein]-yl-[cullin]-L-lysine.", "evidence": [ { "id": "P62878", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62878" } ] }, { "ec_number": "2.3.2.32", "activity": "", "evidence": [ { "id": "P62878", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62878" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "P62878", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62878" } ] } ] }, { "uniprot_ac": "P63147", "gene_name": "Ube2b", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P63147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63147" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P63147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63147" } ] } ] }, { "uniprot_ac": "P68037", "gene_name": "Ube2l3", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P68037", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68037" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P68037", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68037" } ] } ] }, { "uniprot_ac": "P97868", "gene_name": "Rbbp6", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P97868", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97868" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "P97868", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97868" } ] } ] }, { "uniprot_ac": "Q02956", "gene_name": "Prkcz", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q02956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02956" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "Q02956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02956" } ] } ] }, { "uniprot_ac": "Q05A36", "gene_name": "Mex3c", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q05A36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05A36" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q05A36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05A36" } ] } ] }, { "uniprot_ac": "Q06986", "gene_name": "Siah2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q06986", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06986" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q06986", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06986" } ] } ] }, { "uniprot_ac": "Q1PSW8", "gene_name": "Trim71", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q1PSW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q1PSW8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q1PSW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q1PSW8" } ] } ] }, { "uniprot_ac": "Q38HM4", "gene_name": "Trim63", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q38HM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q38HM4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q38HM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q38HM4" } ] } ] }, { "uniprot_ac": "Q3TTA7", "gene_name": "Cblb", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q3TTA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TTA7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q3TTA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TTA7" } ] } ] }, { "uniprot_ac": "Q3U0D9", "gene_name": "Hace1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q3U0D9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3U0D9" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q3U0D9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3U0D9" } ] } ] }, { "uniprot_ac": "Q3U487", "gene_name": "Hectd3", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q3U487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3U487" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q3U487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3U487" } ] } ] }, { "uniprot_ac": "Q3UE37", "gene_name": "Ube2z", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q3UE37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UE37" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q3UE37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UE37" } ] } ] }, { "uniprot_ac": "Q3UIR3", "gene_name": "Dtx3l", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q3UIR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UIR3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q3UIR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UIR3" } ] } ] }, { "uniprot_ac": "Q4U2R1", "gene_name": "Herc2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q4U2R1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4U2R1" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q4U2R1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4U2R1" } ] } ] }, { "uniprot_ac": "Q5FWH2", "gene_name": "Unkl", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "Q5FWH2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5FWH2" } ] } ] }, { "uniprot_ac": "Q5NCC3", "gene_name": "Trim41", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5NCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5NCC3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q5NCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5NCC3" } ] } ] }, { "uniprot_ac": "Q5XPI3", "gene_name": "Rnf123", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5XPI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XPI3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q5XPI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XPI3" } ] } ] }, { "uniprot_ac": "Q62191", "gene_name": "Trim21", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q62191", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62191" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q62191", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62191" } ] } ] }, { "uniprot_ac": "Q62312", "gene_name": "Tgfbr2", "activity": [ { "ec_number": "2.7.11.30", "activity": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein].", "evidence": [ { "id": "Q62312", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62312" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "Q62312", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62312" } ] } ] }, { "uniprot_ac": "Q64729", "gene_name": "Tgfbr1", "activity": [ { "ec_number": "2.7.11.30", "activity": "ATP + L-threonyl-[receptor-protein] = ADP + H(+) + O-phospho-L-threonyl-[receptor-protein].", "evidence": [ { "id": "Q64729", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64729" } ] }, { "ec_number": "2.7.11.30", "activity": "", "evidence": [ { "id": "Q64729", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64729" } ] } ] }, { "uniprot_ac": "Q69ZI1", "gene_name": "Sh3rf1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q69ZI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q69ZI1" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q69ZI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q69ZI1" } ] } ] }, { "uniprot_ac": "Q69ZR2", "gene_name": "Hectd1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q69ZR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q69ZR2" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q69ZR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q69ZR2" } ] } ] }, { "uniprot_ac": "Q6A009", "gene_name": "Ltn1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6A009", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6A009" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q6A009", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6A009" } ] } ] }, { "uniprot_ac": "Q6I6G8", "gene_name": "Hecw2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6I6G8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6I6G8" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q6I6G8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6I6G8" } ] } ] }, { "uniprot_ac": "Q6P073", "gene_name": "Ube2j2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q6P073", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P073" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q6P073", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P073" } ] } ] }, { "uniprot_ac": "Q6PAV2", "gene_name": "Herc4", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6PAV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PAV2" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q6PAV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PAV2" } ] } ] }, { "uniprot_ac": "Q6PCX9", "gene_name": "Trim37", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6PCX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PCX9" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q6PCX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PCX9" } ] } ] }, { "uniprot_ac": "Q6PDX6", "gene_name": "Rnf220", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6PDX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PDX6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q6PDX6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PDX6" } ] } ] }, { "uniprot_ac": "Q6WKZ8", "gene_name": "Ubr2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6WKZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6WKZ8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q6WKZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6WKZ8" } ] } ] }, { "uniprot_ac": "Q6ZPJ3", "gene_name": "Ube2o", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6ZPJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZPJ3" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "Q6ZPJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZPJ3" } ] } ] }, { "uniprot_ac": "Q6ZWZ2", "gene_name": "Ube2r2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q6ZWZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZWZ2" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q6ZWZ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZWZ2" } ] } ] }, { "uniprot_ac": "Q71FD5", "gene_name": "Znrf2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q71FD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q71FD5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q71FD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q71FD5" } ] } ] }, { "uniprot_ac": "Q7TMY8", "gene_name": "Huwe1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q7TMY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TMY8" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q7TMY8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TMY8" } ] } ] }, { "uniprot_ac": "Q7TPV2", "gene_name": "Dzip3", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q7TPV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TPV2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q7TPV2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TPV2" } ] } ] }, { "uniprot_ac": "Q7TSS2", "gene_name": "Ube2q1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q7TSS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TSS2" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q7TSS2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TSS2" } ] } ] }, { "uniprot_ac": "Q80TR8", "gene_name": "Dcaf1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q80TR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80TR8" } ] } ] }, { "uniprot_ac": "Q80U04", "gene_name": "Pja2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q80U04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80U04" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q80U04", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80U04" } ] } ] }, { "uniprot_ac": "Q80U95", "gene_name": "Ube3c", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q80U95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80U95" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q80U95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80U95" } ] } ] }, { "uniprot_ac": "Q80WG7", "gene_name": "Trim36", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q80WG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80WG7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q80WG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80WG7" } ] } ] }, { "uniprot_ac": "Q80X56", "gene_name": "Trim69", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q80X56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80X56" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q80X56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80X56" } ] } ] }, { "uniprot_ac": "Q80ZI6", "gene_name": "Lrsam1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q80ZI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80ZI6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q80ZI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80ZI6" } ] } ] }, { "uniprot_ac": "Q810I2", "gene_name": "Trim50", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q810I2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q810I2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q810I2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q810I2" } ] } ] }, { "uniprot_ac": "Q8BH75", "gene_name": "Rnf41", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8BH75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BH75" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8BH75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BH75" } ] } ] }, { "uniprot_ac": "Q8BKD6", "gene_name": "Rnf144b", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "Q8BKD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BKD6" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "Q8BKD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BKD6" } ] } ] }, { "uniprot_ac": "Q8BM54", "gene_name": "Mylip", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8BM54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BM54" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8BM54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BM54" } ] } ] }, { "uniprot_ac": "Q8BX13", "gene_name": "Ube3d", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8BX13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BX13" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q8BX13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BX13" } ] } ] }, { "uniprot_ac": "Q8BZZ3", "gene_name": "Wwp1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8BZZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BZZ3" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q8BZZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BZZ3" } ] } ] }, { "uniprot_ac": "Q8C432", "gene_name": "Rnf182", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8C432", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8C432" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8C432", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8C432" } ] } ] }, { "uniprot_ac": "Q8C7M3", "gene_name": "Trim9", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8C7M3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8C7M3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8C7M3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8C7M3" } ] } ] }, { "uniprot_ac": "Q8C863", "gene_name": "Itch", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8C863", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8C863" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q8C863", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8C863" } ] } ] }, { "uniprot_ac": "Q8CCJ3", "gene_name": "Ufl1", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "Q8CCJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CCJ3" } ] } ] }, { "uniprot_ac": "Q8CDU6", "gene_name": "Hectd2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8CDU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CDU6" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q8CDU6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CDU6" } ] } ] }, { "uniprot_ac": "Q8CFI0", "gene_name": "Nedd4l", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8CFI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CFI0" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q8CFI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CFI0" } ] }, { "ec_number": "2.3.2.36", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine.", "evidence": [ { "id": "Q8CFI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CFI0" } ] }, { "ec_number": "2.3.2.36", "activity": "", "evidence": [ { "id": "Q8CFI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CFI0" } ] } ] }, { "uniprot_ac": "Q8CFI2", "gene_name": "Cdc34", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8CFI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CFI2" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q8CFI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CFI2" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q8CFI2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CFI2" } ] } ] }, { "uniprot_ac": "Q8CH72", "gene_name": "Trim32", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8CH72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CH72" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8CH72", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CH72" } ] } ] }, { "uniprot_ac": "Q8CHG5", "gene_name": "Arel1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8CHG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CHG5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q8CHG5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CHG5" } ] } ] }, { "uniprot_ac": "Q8K2Z8", "gene_name": "Ube2q2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q8K2Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K2Z8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q8K2Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K2Z8" } ] } ] }, { "uniprot_ac": "Q8R516", "gene_name": "Mib2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8R516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R516" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8R516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R516" } ] } ] }, { "uniprot_ac": "Q8VDW4", "gene_name": "Ube2w", "activity": [ { "ec_number": "2.3.2.25", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-N-terminal-amino acid = [E1 ubiquitin-activating enzyme]-L-cysteine + N-terminal-ubiquitinyl-[acceptor protein].", "evidence": [ { "id": "Q8VDW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VDW4" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q8VDW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VDW4" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q8VDW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VDW4" } ] } ] }, { "uniprot_ac": "Q8VEM1", "gene_name": "Rnf130", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8VEM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VEM1" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8VEM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VEM1" } ] } ] }, { "uniprot_ac": "Q8VIG6", "gene_name": "Traip", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8VIG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VIG6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8VIG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VIG6" } ] } ] }, { "uniprot_ac": "Q91V17", "gene_name": "Znrf1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q91V17", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91V17" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q91V17", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91V17" } ] } ] }, { "uniprot_ac": "Q91W82", "gene_name": "Ube2e2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q91W82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91W82" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q91W82", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91W82" } ] } ] }, { "uniprot_ac": "Q91YL2", "gene_name": "Rnf126", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q91YL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91YL2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q91YL2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91YL2" } ] } ] }, { "uniprot_ac": "Q921J4", "gene_name": "Ube2s", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q921J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q921J4" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q921J4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q921J4" } ] } ] }, { "uniprot_ac": "Q922B6", "gene_name": "Traf7", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q922B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q922B6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q922B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q922B6" } ] } ] }, { "uniprot_ac": "Q925F4", "gene_name": "Ubox5", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q925F4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q925F4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q925F4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q925F4" } ] } ] }, { "uniprot_ac": "Q99KR6", "gene_name": "Rnf34", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q99KR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99KR6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q99KR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99KR6" } ] } ] }, { "uniprot_ac": "Q99ML9", "gene_name": "Rnf111", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q99ML9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99ML9" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q99ML9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99ML9" } ] } ] }, { "uniprot_ac": "Q99PQ2", "gene_name": "Trim11", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q99PQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99PQ2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q99PQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99PQ2" } ] } ] }, { "uniprot_ac": "Q9CQE0", "gene_name": "Rnf138", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9CQE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CQE0" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9CQE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CQE0" } ] } ] }, { "uniprot_ac": "Q9CR50", "gene_name": "Rchy1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9CR50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CR50" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9CR50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CR50" } ] } ] }, { "uniprot_ac": "Q9CUN6", "gene_name": "Smurf1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9CUN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CUN6" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q9CUN6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CUN6" } ] } ] }, { "uniprot_ac": "Q9CY34", "gene_name": "Ube2f", "activity": [ { "ec_number": "2.3.2.34", "activity": "[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.", "evidence": [ { "id": "Q9CY34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CY34" } ] }, { "ec_number": "2.3.2.34", "activity": "", "evidence": [ { "id": "Q9CY34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CY34" } ] } ] }, { "uniprot_ac": "Q9D074", "gene_name": "Mgrn1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9D074", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D074" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9D074", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D074" } ] } ] }, { "uniprot_ac": "Q9D0C1", "gene_name": "Rnf115", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9D0C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D0C1" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9D0C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D0C1" } ] } ] }, { "uniprot_ac": "Q9D1C1", "gene_name": "Ube2c", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9D1C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D1C1" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q9D1C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D1C1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q9D1C1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D1C1" } ] } ] }, { "uniprot_ac": "Q9DBK7", "gene_name": "Uba7", "activity": [ { "ec_number": "6.2.1.45", "activity": "ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.", "evidence": [ { "id": "Q9DBK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBK7" } ] }, { "ec_number": "6.2.1.45", "activity": "", "evidence": [ { "id": "Q9DBK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBK7" } ] } ] }, { "uniprot_ac": "Q9DBU5", "gene_name": "Rnf6", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9DBU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBU5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9DBU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBU5" } ] } ] }, { "uniprot_ac": "Q9ES34", "gene_name": "Ube3b", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9ES34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ES34" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q9ES34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ES34" } ] } ] }, { "uniprot_ac": "Q9ESN2", "gene_name": "Trim39", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9ESN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ESN2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9ESN2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ESN2" } ] } ] }, { "uniprot_ac": "Q9ET26", "gene_name": "Rnf114", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9ET26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ET26" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9ET26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ET26" } ] } ] }, { "uniprot_ac": "Q9JI90", "gene_name": "Rnf14", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "Q9JI90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JI90" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "Q9JI90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9JI90" } ] } ] }, { "uniprot_ac": "Q9JIY2", "gene_name": "Cbll1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating 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"ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "Q9QUI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QUI0" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "Q9QUI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QUI0" } ] } ] }, { "uniprot_ac": "Q9QXP6", "gene_name": "Mkrn1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9QXP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QXP6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9QXP6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QXP6" } ] } ] }, { "uniprot_ac": "Q9QZR0", "gene_name": "Rnf25", "activity": [ { "ec_number": "2.3.2.27", 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