{ "uniprot_canonical_ac": "Q9CUB6-1", "uniprot_ac": "Q9CUB6", "uniprot_id": "OTUD1_MOUSE", "mass": { "chemical_mass": 48823.0, "monoisotopic_mass": 48823.0 }, "refseq": { "ac": "NP_081991", "name": "OTU domain-containing protein 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081991" }, "gene_names": [ { "name": "Otud1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q9CUB6", "id": "Q9CUB6" }, { "name": "4933428L19Rik", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081991", "id": "NP_081991" }, { "name": "Otud1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081991", "id": "NP_081991" } ], "protein_names": [ { "name": "OTU domain-containing protein 1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q9CUB6" }, { "name": "3.4.19.12", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9CUB6" }, { "name": "OTU domain-containing protein 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081991", "id": "NP_081991" }, { "name": "likely ortholog of H. sapiens OTU domain containing 1 (OTUD1)", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081991", "id": "NP_081991" } ], "function": [ { "annotation": "Deubiquitinating enzyme that specifically hydrolyzes 'Lys-63'-linked polyubiquitin to monoubiquitin. Required for the stability and translation of a subset mRNAs with a high abundance of rare codons by mediating deubiquitination of 40S ribosomal protein RPS10/eS10, thereby antagonizing ZNF598-mediated 40S ubiquitination. The abundance of rare codons in mRNAs can limit the translation rate and can lead to ribosome collisions that trigger activation of ribosome quality control (RQC) pathway by ZNF598. OTUD1-mediated deubiquitination prevents activation of the RQC and subsequent dissociation of ribosomes and stimulates formation of polysomes and translation.", "evidence": [ { "database": "UniProtKB", "id": "Q9CUB6", "url": "https://www.uniprot.org/uniprot/Q9CUB6#function" }, { "database": "UniProtKB", "id": "Q5VV17", "url": "https://www.uniprot.org/uniprot/Q5VV17#function" } ] }, { "annotation": "Mouse endothelial OTUD1 promotes angiotensin II-induced vascular remodeling by deubiquitinating SMAD3.", "evidence": [ { "database": "RefSeq", "id": "NP_081991", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081991" }, { "database": "PubMed", "id": "36579465", "url": "https://glygen.org/publication/PubMed/36579465" } ] }, { "annotation": "OTUD1 Regulates Antifungal Innate Immunity through Deubiquitination of CARD9. Erratum:[J Immunol. 2022 Mar 1;208(5):1305-1306. PMID: 35101896]", "evidence": [ { "database": "RefSeq", "id": "NP_081991", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081991" }, { "database": "PubMed", "id": "33789983", "url": "https://glygen.org/publication/PubMed/33789983" } ] }, { "annotation": "OTUD1 promotes pathological cardiac remodeling and heart failure by targeting STAT3 in cardiomyocytes. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_081991", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081991" }, { "database": "PubMed", "id": "37153745", "url": "https://glygen.org/publication/PubMed/37153745" } ] }, { "annotation": "The OTUD1-Notch2-ICD axis orchestrates allogeneic T cell-mediated graft-versus-host disease.", "evidence": [ { "database": "RefSeq", "id": "NP_081991", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081991" }, { "database": "PubMed", "id": "36574342", "url": "https://glygen.org/publication/PubMed/36574342" } ] }, { "annotation": "The deubiquitinase OTUD1 inhibits colonic inflammation by suppressing RIPK1-mediated NF-kappaB signaling.", "evidence": [ { "database": "RefSeq", "id": "NP_081991", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081991" }, { "database": "PubMed", "id": "34876703", "url": "https://glygen.org/publication/PubMed/34876703" } ] }, { "annotation": "We report the establishment of OTUD1-specific monoclonal antibodies (mAbs), using the rat medial iliac lymph node method. The generated antibodies recognize the N-terminal portion (aa. 1-290) of human and mouse OTUD1 proteins", "evidence": [ { "database": "RefSeq", "id": "NP_081991", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081991" }, { "database": "PubMed", "id": "30130141", "url": "https://glygen.org/publication/PubMed/30130141" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q9CUB6", "url": "https://www.uniprot.org/uniprot/Q9CUB6" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Otud1", "url": "https://www.uniprot.org/uniprot/Q9CUB6", "locus": { "chromosome": "2", "start_pos": 19665394, "end_pos": 19662563, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000043415", "url": "https://www.ensembl.org/id/ENSMUSG00000043415" } ] } } ], "crossref": [ { "id": "ENSMUSG00000043415", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000043415", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd22747", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22747", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "71198", "url": "https://www.ncbi.nlm.nih.gov/gene/71198", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR003323", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003323", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR038765", "url": "https://www.ebi.ac.uk/interpro/entry/IPR038765", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:71198", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:71198", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1918448", "url": "http://www.informatics.jax.org/marker/MGI:1918448", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "CTHYPSG", "url": "https://omabrowser.org/oma/group/CTHYPSG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5353202at2759", "url": "http://www.orthodb.org/?query=5353202at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR12419", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12419", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR12419:SF101", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12419:SF101", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02338", "url": "http://pfam.xfam.org/family/PF02338", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q9CUB6", "url": "http://purl.obolibrary.org/obo/PR_Q9CUB6", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-5357786", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5357786", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-5357905", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5357905", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-5357956", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5357956", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_081991", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081991", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q9CUB6", "url": "https://www.uniprot.org/uniprot/Q9CUB6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9CUB6-1", "url": "https://www.uniprot.org/uniprot/Q9CUB6-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQLYSSVCTHYPAGTPGPTAAAPPATAAAAFKVSLQSASPAAAAPEPDTGERPPAAATEPREAAAAAAMPAFSACFERSGSAAAPPGACSKPPLPPHFTSTAHIAVRALGAERLLLPPPSAPSPPRRGSSAWLLEELLRPDEPAAPNAVRDAPDRNFRLSEHRQALAASQHRAPAPAPVGPEPGAGPGSGPWGEERRAERSSRGWDRASGRSDASGSDALRRQDPEAEAHPVPAPARSSGEPAQNGEGEAVGTSRADPRDEKLALYLAEVERQDKYLRQRNKYRFHIIPDGNCLYRAVSKTVYGDQSLHRELREQTVHYIADHLDHFSPLIEGDVGEFIIAAAQDGAWAGYPELLAMGQMLNVNIHLTTGGRLESPTVSTMIHYLGPEDSLRPSIWLSWLSNGHYDAVFDHSYPNPEYDNWCKQTQIQKKRDEELAKSMAISLSKMYIEQNACS", "length": 454, "header": "sp|Q9CUB6-1|OTUD1_MOUSE Isoform 1 of OTU domain-containing protein 1 OS=Mus musculus OX=10090 GN=Otud1 PE=1 SV=2 CANONICAL=Q9CUB6-1" }, "isoforms": [ { "isoform_ac": "Q9CUB6-1", "url": "", "sequence": { "sequence": "MQLYSSVCTHYPAGTPGPTAAAPPATAAAAFKVSLQSASPAAAAPEPDTGERPPAAATEPREAAAAAAMPAFSACFERSGSAAAPPGACSKPPLPPHFTSTAHIAVRALGAERLLLPPPSAPSPPRRGSSAWLLEELLRPDEPAAPNAVRDAPDRNFRLSEHRQALAASQHRAPAPAPVGPEPGAGPGSGPWGEERRAERSSRGWDRASGRSDASGSDALRRQDPEAEAHPVPAPARSSGEPAQNGEGEAVGTSRADPRDEKLALYLAEVERQDKYLRQRNKYRFHIIPDGNCLYRAVSKTVYGDQSLHRELREQTVHYIADHLDHFSPLIEGDVGEFIIAAAQDGAWAGYPELLAMGQMLNVNIHLTTGGRLESPTVSTMIHYLGPEDSLRPSIWLSWLSNGHYDAVFDHSYPNPEYDNWCKQTQIQKKRDEELAKSMAISLSKMYIEQNACS", "length": 454, "header": "sp|Q9CUB6-1|OTUD1_MOUSE Isoform 1 of OTU domain-containing protein 1 OS=Mus musculus OX=10090 GN=Otud1 PE=1 SV=2 CANONICAL=Q9CUB6-1" }, "locus": { "chromosome": "2", "start_pos": 19664234, "end_pos": 19662873, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000052168", "url": "https://www.ensembl.org/id/ENSMUST00000052168" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000100617", "url": "https://www.ensembl.org/id/ENSMUSP00000100617" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Generation of Rat Monoclonal Antibodies Against a Deubiquitinase, Ovarian Tumor Domain-Containing Protein 1.", "journal": "Monoclonal antibodies in immunodiagnosis and immunotherapy", "date": "2018", "authors": "Oikawa D, Shiota M, Goto E, Komakura K, Wanibuchi H, Tokunaga F", "evidence": [ { "database": "RefSeq", "id": "NP_081991", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081991" } ], "reference": [ { "type": "PubMed", "id": "30130141", "url": "https://glygen.org/publication/PubMed/30130141" } ] }, { "title": "OTUD1 Regulates Antifungal Innate Immunity through Deubiquitination of CARD9.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2021", "authors": "Chen X, Zhang H, Wang X, Shao Z, Li Y, Zhao G, Liu F, Liu B, Zheng Y, Chen T, Zheng H, Zhang L, Gao C", "evidence": [ { "database": "RefSeq", "id": "NP_081991", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081991" } ], "reference": [ { "type": "PubMed", "id": "33789983", "url": "https://glygen.org/publication/PubMed/33789983" } ] }, { "title": "The deubiquitinase OTUD1 inhibits colonic inflammation by suppressing RIPK1-mediated NF-kappaB signaling.", "journal": "Cellular & molecular immunology", "date": "2022", "authors": "Wu B, Qiang L, Zhang Y, Fu Y, Zhao M, Lei Z, Lu Z, Wei YG, Dai H, Ge Y, Liu M, Zhou X, Peng Z, Li H, Cui CP, Wang J, Zheng H, Liu CH, Zhang L", "evidence": [ { "database": "RefSeq", "id": "NP_081991", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081991" } ], "reference": [ { "type": "PubMed", "id": "34876703", "url": "https://glygen.org/publication/PubMed/34876703" } ] }, { "title": "The OTUD1-Notch2-ICD axis orchestrates allogeneic T cell-mediated graft-versus-host disease.", "journal": "Blood", "date": "2022-12-27", "authors": "Cheng Qiao, Wang Dong, Lai Xiaoxuan, Liu Yin, Zuo Yibo, Zhang Wenli, Lei Lei, Chen Jia, Liu Hong, Wang Ying, Liu Haiyan, Zheng Hui, Wu Depei, Xu Yang", "evidence": [ { "database": "RefSeq", "id": "NP_081991", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081991" } ], "reference": [ { "type": "PubMed", "id": "36574342", "url": "https://glygen.org/publication/PubMed/36574342" } ] }, { "title": "Mouse endothelial OTUD1 promotes angiotensin II-induced vascular remodeling by deubiquitinating SMAD3.", "journal": "EMBO reports", "date": "2022-12-29", "authors": "Huang Zhuqi, Shen Sirui, Wang Mengyang, Li Weixin, Wu Gaojun, Huang Weijian, Luo Wu, Liang Guang", "evidence": [ { "database": "RefSeq", "id": "NP_081991", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081991" } ], "reference": [ { "type": "PubMed", "id": "36579465", "url": "https://glygen.org/publication/PubMed/36579465" } ] }, { "title": "OTUD1 promotes pathological cardiac remodeling and heart failure by targeting STAT3 in cardiomyocytes.", "journal": "Theranostics", "date": "2023", "authors": "Wang Mengyang, Han Xue, Yu Tianxiang, Wang Minxiu, Luo Wu, Zou Chunpeng, Li Xiuyun, Li Gao, Wu Gaojun, Wang Yi, Liang Guang", "evidence": [ { "database": "RefSeq", "id": "NP_081991", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081991" } ], "reference": [ { "type": "PubMed", "id": "37153745", "url": "https://glygen.org/publication/PubMed/37153745" } ] } ], "pathway": [ { "id": "mmu:71198", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:71198", "resource": "KEGG Pathway" }, { "id": "R-MMU-5357786", "name": "TNFR1-induced proapoptotic signaling", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5357786", "resource": "Reactome", "description": "TNFR1-induced proapoptotic signaling" }, { "id": "R-MMU-5357905", "name": "Regulation of TNFR1 signaling", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5357905", "resource": "Reactome", "description": "Regulation of TNFR1 signaling" }, { "id": "R-MMU-5357956", "name": "TNFR1-induced NF-kappa-B signaling pathway", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5357956", "resource": "Reactome", "description": "TNFR1-induced NF-kappa-B signaling pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZNC0-1", "protein_name": "ubiquitinyl hydrolase 1", "gene_name": "Otud1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MQLYSSVCTHYPAGTPGPTAAAPPATTAAFKVSLQSAGPAAAAPEPDTGERPPAAATEPREAAAAAAMPAFSACFERSGSATAAAPPGACCKPPLPPHFTSTAHIAVRALGAERLLLPPPSAPAPPRRGSSAWLLEELLRPDEPAAPNAARDAPDRNFRLSEHRQALAAAQHRAPAPAPVGPEPGAGPWSEERRTERSPRGWDRASGRSDASGADAHRRPDPEIEVHPVPAPAPAPARSSGDPTQNGEGEAVGAPRADPRDEKLALYLAEVERQDKYLRQRNKYRFHIIPDGNCLYRAVSKTVYGDQSLHRELREQTVHYIADHLDHFSPLIEGDVGEFIIAAAQDGAWAGYPELLAMGQMLNVNIHLTTGGRLESPTVSTMVHYLGPEDSLRPSIWLSWLSNGHYDAVFDHSYPNPEYDNWCKQTQMQRKRDEELAKSMAISLSKMYIEQNACS", "length": 455 }, "evidence": [ { "id": "45243129", "url": "http://www.informatics.jax.org/homology/45243129", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q5VV17-1", "protein_name": "OTU domain-containing protein 1", "gene_name": "OTUD1", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MQLYSSVCTHYPAGAPGPTAAAPAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAEHREAAAVPAAKMPAFSSCFEVVSGAAAPASAAAGPPGASCKPPLPPHYTSTAQITVRALGADRLLLHGPDPVPGAAGSAAAPRGRCLLLAPAPAAPVPPRRGSSAWLLEELLRPDCPEPAGLDATREGPDRNFRLSEHRQALAAAKHRGPAATPGSPDPGPGPWGEEHLAERGPRGWERGGDRCDAPGGDAARRPDPEAEAPPAGSIEAAPSSAAEPVIVSRSDPRDEKLALYLAEVEKQDKYLRQRNKYRFHIIPDGNCLYRAVSKTVYGDQSLHRELREQTVHYIADHLDHFSPLIEGDVGEFIIAAAQDGAWAGYPELLAMGQMLNVNIHLTTGGRLESPTVSTMIHYLGPEDSLRPSIWLSWLSNGHYDAVFDHSYPNPEYDNWCKQTQVQRKRDEELAKSMAISLSKMYIEQNACS", "length": 481 }, "evidence": [ { "id": "45243129", "url": "http://www.informatics.jax.org/homology/45243129", "database": "MGI" }, { "id": "Q9CUB6", "url": "https://omabrowser.org/oma/group/Q9CUB6/", "database": "OMA" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "protein K63-linked deubiquitination", "id": "GO:0070536", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070536", "evidence": [ { "database": "UniProtKB", "id": "Q9CUB6", "url": "https://www.uniprot.org/uniprot/Q9CUB6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "cysteine-type deubiquitinase activity", "id": "GO:0004843", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004843", "evidence": [ { "database": "UniProtKB", "id": "Q9CUB6", "url": "https://www.uniprot.org/uniprot/Q9CUB6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-MMU-140978", "name": "TRADD:TRAF2:RIP1 complex binds FADD", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P35123-1", "Q9CUB6-1", "Q80TQ2-1", "B2RUR8-1", "Q60855-1", "Q60769-1", "P39429-1", "O88623-3", "Q9QZL6-1" ], "evidence": [ { "id": "R-MMU-140978", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-140978" } ] }, { "id": "R-MMU-5357776", "name": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O08863-1", "Q9WUB0-1", "O88351-1", "Q924T7-1", "P35123-1", "Q9CUB6-1", "Q80TQ2-1", "B2RUR8-1", "Q60680-1", "Q62210-1", "Q60989-1", "Q60855-1", "Q60769-1", "P39429-1", "O88623-3", "Q9QZL6-1" ], "evidence": [ { "id": "R-MMU-5357776", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5357776" } ] }, { "id": "R-MMU-5357845", "name": "K63polyUb-RIPK1 is deubiquitinated", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O08863-1", "P35123-1", "Q9CUB6-1", "Q80TQ2-1", "B2RUR8-1", "Q62210-1", "Q60989-1", "Q60855-1", "Q60769-1", "P39429-1", "O88623-3", "Q9QZL6-1" ], "evidence": [ { "id": "R-MMU-5357845", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5357845" } ] }, { "id": "R-MMU-5357860", "name": "TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O08863-1", "Q9WUB0-1", "Q924T7-1", "P35123-1", "Q9CUB6-1", "Q80TQ2-1", "B2RUR8-1", "Q62210-1", "Q60989-1", "Q62073-1", "Q60855-1", "Q60769-1", "P39429-1", "O88623-3", "Q9QZL6-1" ], "evidence": [ { "id": "R-MMU-5357860", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5357860" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "B2RUR8", "gene_name": "Otud7b", "activity": [ { "ec_number": "3.4.19.12", "activity": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).", "evidence": [ { "id": "B2RUR8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RUR8" } ] }, { 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