{
    "uniprot_canonical_ac": "Q9CRB9-1",
    "uniprot_ac": "Q9CRB9",
    "uniprot_id": "MIC19_MOUSE",
    "mass": {
        "chemical_mass": 26335.0,
        "monoisotopic_mass": 26335.0
    },
    "refseq": {
        "ac": "NP_079612",
        "name": "MICOS complex subunit Mic19",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079612"
    },
    "gene_names": [
        {
            "name": "Chchd3",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q9CRB9",
            "id": "Q9CRB9"
        },
        {
            "name": "0610041L09Rik; 1700039J09Rik; Micos19",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079612",
            "id": "NP_079612"
        },
        {
            "name": "Chchd3",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079612",
            "id": "NP_079612"
        },
        {
            "name": "Mic19",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q9CRB9",
            "id": "Q9CRB9"
        }
    ],
    "protein_names": [
        {
            "name": "MICOS complex subunit Mic19",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q9CRB9"
        },
        {
            "name": "Coiled-coil-helix-coiled-coil-helix domain-containing protein 3",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q9CRB9"
        },
        {
            "name": "MICOS complex subunit Mic19",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079612",
            "id": "NP_079612"
        },
        {
            "name": "coiled-coil-helix-coiled-coil-helix domain-containing protein 3, mitochondrial",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079612",
            "id": "NP_079612"
        }
    ],
    "function": [
        {
            "annotation": "ChChd3 is a scaffolding protein that stabilizes protein complexes involved in maintaining crista architecture and protein import and is thus essential for maintaining mitochondrial structure and function.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_079612",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079612"
                },
                {
                    "database": "PubMed",
                    "id": "21081504",
                    "url": "https://glygen.org/publication/PubMed/21081504"
                }
            ]
        },
        {
            "annotation": "Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9CRB9",
                    "url": "https://www.uniprot.org/uniprot/Q9CRB9#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q9NX63",
                    "url": "https://www.uniprot.org/uniprot/Q9NX63#function"
                },
                {
                    "database": "PubMed",
                    "id": "21081504",
                    "url": "https://glygen.org/publication/PubMed/21081504"
                }
            ]
        },
        {
            "annotation": "Liver mitochondrial cristae organizing protein MIC19 promotes energy expenditure and pedestrian locomotion by altering nucleotide metabolism.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_079612",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079612"
                },
                {
                    "database": "PubMed",
                    "id": "37473754",
                    "url": "https://glygen.org/publication/PubMed/37473754"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [
        {
            "start_pos": 2,
            "end_pos": 2,
            "sequence_org": "G",
            "sequence_mut": "A",
            "comment": "Loss of SAMM50-binding. Reduced affinity toward OPA1. No effect on IMMT-binding.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9CRB9",
                    "url": "https://www.uniprot.org/uniprot/Q9CRB9"
                },
                {
                    "database": "PubMed",
                    "id": "21081504",
                    "url": "https://glygen.org/publication/PubMed/21081504"
                }
            ]
        }
    ],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9CRB9",
                    "url": "https://www.uniprot.org/uniprot/Q9CRB9"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Chchd3",
            "url": "https://www.uniprot.org/uniprot/Q9CRB9",
            "locus": {
                "chromosome": "6",
                "start_pos": 32767911,
                "end_pos": 33037195,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000053768",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000053768"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000053768",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000053768",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "66075",
            "url": "https://www.ncbi.nlm.nih.gov/gene/66075",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "GPDB0002173",
            "url": "https://acgg.asia/db/gpdb/symbol/GPDB0002173",
            "database": "GlycoProtDB",
            "categories": [
                "Glycoproteomics"
            ]
        },
        {
            "id": "GPDB0007288",
            "url": "https://acgg.asia/db/gpdb/symbol/GPDB0007288",
            "database": "GlycoProtDB",
            "categories": [
                "Glycoproteomics"
            ]
        },
        {
            "id": "GPDB0007425",
            "url": "https://acgg.asia/db/gpdb/symbol/GPDB0007425",
            "database": "GlycoProtDB",
            "categories": [
                "Glycoproteomics"
            ]
        },
        {
            "id": "GPDB0007883",
            "url": "https://acgg.asia/db/gpdb/symbol/GPDB0007883",
            "database": "GlycoProtDB",
            "categories": [
                "Glycoproteomics"
            ]
        },
        {
            "id": "Q9CRB9",
            "url": "https://www.ebi.ac.uk/intact/interactors/id:Q9CRB9*",
            "database": "IntAct",
            "categories": [
                "Other"
            ]
        },
        {
            "id": "IPR007964",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR007964",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:66075",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:66075",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "1913325",
            "url": "http://www.informatics.jax.org/marker/MGI:1913325",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "Q9CRB9",
            "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9CRB9",
            "database": "O-GlcNAc Database",
            "categories": [
                "Glycoproteomics"
            ]
        },
        {
            "id": "LANQYQH",
            "url": "https://omabrowser.org/oma/group/LANQYQH/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "2942444at2759",
            "url": "http://www.orthodb.org/?query=2942444at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR21588",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21588",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR21588:SF2",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21588:SF2",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF05300",
            "url": "http://pfam.xfam.org/family/PF05300",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q9CRB9",
            "url": "http://purl.obolibrary.org/obo/PR_Q9CRB9",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_079612",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079612",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "D3Z0L4",
            "url": "https://www.uniprot.org/uniprot/D3Z0L4",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "D3Z0L4-1",
            "url": "https://www.uniprot.org/uniprot/D3Z0L4-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "F6QFL0",
            "url": "https://www.uniprot.org/uniprot/F6QFL0",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "F6QFL0-1",
            "url": "https://www.uniprot.org/uniprot/F6QFL0-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q9CRB9",
            "url": "https://www.uniprot.org/uniprot/Q9CRB9",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q9CRB9-1",
            "url": "https://www.uniprot.org/uniprot/Q9CRB9-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q9D9P1",
            "url": "https://www.uniprot.org/uniprot/Q9D9P1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q9D9P1-1",
            "url": "https://www.uniprot.org/uniprot/Q9D9P1-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "S4R238",
            "url": "https://www.uniprot.org/uniprot/S4R238",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "S4R238-1",
            "url": "https://www.uniprot.org/uniprot/S4R238-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MGGTASTRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSSVYGASVSDEDLKRRVAEELALEQAKKESEHQRRLKQARDLERERAAANEQLTRAVLRERISSEEERMKAKHLARQLEEKDRVMRKQDAFYKEQLARLEERSSEFYKVTTEEYQKAAEEVEAKFKRYEYHPVCADLQTKILQCYRQNTQQTLSCSALASQYMHCVNHAKQSMLEKGG",
        "length": 227,
        "header": "sp|Q9CRB9-1|MIC19_MOUSE Isoform 1 of MICOS complex subunit Mic19  OS=Mus musculus OX=10090 GN=Chchd3 PE=1 SV=1 CANONICAL=Q9CRB9-1"
    },
    "isoforms": [
        {
            "isoform_ac": "D3Z0L4-1",
            "url": "",
            "sequence": {
                "sequence": "MGGTASTRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSSVYGASVSDEDLKRRVAEELALEQAKKESEHQRRLKQARDLERERAAANEQLTRAVLRERISSEEERMKAKHLDIEDKARQLEEKDRVMRKQDAFYKEQLARLEERSSEFYKVTTEEYQKAAEEVEAKFKRYEYHPVCADLQ",
                "length": 192,
                "header": "tr|D3Z0L4-1|D3Z0L4_MOUSE Computationally mapped isoform of Coiled-coil-helix-coiled-coil-helix domain containing 3  OS=Mus musculus OX=10090 GN=Chchd3 PE=1 SV=1 CANONICAL=Q9CRB9-1"
            },
            "locus": {
                "chromosome": "6",
                "start_pos": 33037015,
                "end_pos": 32780924,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000127666.8",
                        "url": "https://www.ensembl.org/id/ENSMUST00000127666.8"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000123220.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000123220.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "F6QFL0-1",
            "url": "",
            "sequence": {
                "sequence": "AFYKEQLARLEERSSEFYKVTTEEYQKAAEEVEAKFKRYEYHPVCADLQTKILQCYRQNTQQTLSCSALASQYMHCVNHAKQSMLEKGG",
                "length": 89,
                "header": "tr|F6QFL0-1|MIC19_MOUSE Computationally mapped isoform of MICOS complex subunit Mic19  OS=Mus musculus OX=10090 GN=Chchd3 PE=1 SV=1 CANONICAL=Q9CRB9-1"
            },
            "locus": {
                "chromosome": "6",
                "start_pos": 32869265,
                "end_pos": 32769841,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000129069.8",
                        "url": "https://www.ensembl.org/id/ENSMUST00000129069.8"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000121589.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000121589.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q9CRB9-1",
            "url": "",
            "sequence": {
                "sequence": "MGGTASTRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSSVYGASVSDEDLKRRVAEELALEQAKKESEHQRRLKQARDLERERAAANEQLTRAVLRERISSEEERMKAKHLARQLEEKDRVMRKQDAFYKEQLARLEERSSEFYKVTTEEYQKAAEEVEAKFKRYEYHPVCADLQTKILQCYRQNTQQTLSCSALASQYMHCVNHAKQSMLEKGG",
                "length": 227,
                "header": "sp|Q9CRB9-1|MIC19_MOUSE Isoform 1 of MICOS complex subunit Mic19  OS=Mus musculus OX=10090 GN=Chchd3 PE=1 SV=1 CANONICAL=Q9CRB9-1"
            },
            "locus": {
                "chromosome": "6",
                "start_pos": 33037015,
                "end_pos": 32769841,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000066379",
                        "url": "https://www.ensembl.org/id/ENSMUST00000066379"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000070149",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000070149"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q9D9P1-1",
            "url": "",
            "sequence": {
                "sequence": "MGGTASTRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSSVYGASVSDEDLKRRVAEELALEQAKKESEHQRRLKQARDLERERAAANEQLTRAVLRERISSEEERMKAKHLARQLEEKDRVMRKQDAFYKEQLARLEERSSEFYKVTTEEYQKAAEEVEAKFK",
                "length": 175,
                "header": "tr|Q9D9P1-1|MIC19_MOUSE Computationally mapped isoform of MICOS complex subunit Mic19  OS=Mus musculus OX=10090 GN=Chchd3 PE=1 SV=1 CANONICAL=Q9CRB9-1"
            },
            "locus": {
                "chromosome": "6",
                "start_pos": 33037015,
                "end_pos": 32829079,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000115091.2",
                        "url": "https://www.ensembl.org/id/ENSMUST00000115091.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000110743.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000110743.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "S4R238-1",
            "url": "",
            "sequence": {
                "sequence": "MGGTASTRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSSVYGASVSDEDLKRRVAEELALEQAKKESEHQRR",
                "length": 84,
                "header": "tr|S4R238-1|S4R238_MOUSE Computationally mapped isoform of Coiled-coil-helix-coiled-coil-helix domain containing 3  OS=Mus musculus OX=10090 GN=Chchd3 PE=1 SV=1 CANONICAL=Q9CRB9-1"
            },
            "locus": {
                "chromosome": "6",
                "start_pos": 33037015,
                "end_pos": 32945201,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000124436.8",
                        "url": "https://www.ensembl.org/id/ENSMUST00000124436.8"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000138484.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000138484.2"
                    }
                ]
            }
        }
    ],
    "glycosylation": [
        {
            "glytoucan_ac": "G49108TO",
            "type": "O-linked",
            "subtype": "O-GlcNAcylation",
            "site_category": "reported_with_glycan",
            "site_seq": "",
            "relation": "attached",
            "comment": "O-GlcNAcylation",
            "evidence": [
                {
                    "id": "Q9CRB9",
                    "database": "O-GlcNAc Database",
                    "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q9CRB9"
                },
                {
                    "id": "36288343",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/36288343"
                },
                {
                    "id": "33300544",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/33300544"
                },
                {
                    "id": "29187734",
                    "database": "PubMed",
                    "url": "https://glygen.org/publication/PubMed/29187734"
                }
            ]
        }
    ],
    "phosphorylation": [
        {
            "start_pos": 29,
            "end_pos": 29,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9CRB9",
                    "url": "https://www.uniprot.org/uniprot/Q9CRB9"
                },
                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q9CRB9",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9CRB9"
                }
            ],
            "site_lbl": "Ser29"
        },
        {
            "start_pos": 49,
            "end_pos": 49,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Tyr",
            "comment": "Phosphotyrosine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9CRB9",
                    "url": "https://www.uniprot.org/uniprot/Q9CRB9"
                }
            ],
            "site_lbl": "Tyr49"
        },
        {
            "start_pos": 50,
            "end_pos": 50,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9CRB9",
                    "url": "https://www.uniprot.org/uniprot/Q9CRB9"
                },
                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q9CRB9",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9CRB9"
                }
            ],
            "site_lbl": "Ser50"
        },
        {
            "start_pos": 51,
            "end_pos": 51,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9CRB9",
                    "url": "https://www.uniprot.org/uniprot/Q9CRB9"
                },
                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q9CRB9",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9CRB9"
                }
            ],
            "site_lbl": "Ser51"
        },
        {
            "start_pos": 56,
            "end_pos": 56,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9CRB9",
                    "url": "https://www.uniprot.org/uniprot/Q9CRB9"
                },
                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                },
                {
                    "database": "iPTMnet",
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        {
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            "date": "2011",
            "authors": "Darshi M, Mendiola VL, Mackey MR, Murphy AN, Koller A, Perkins GA, Ellisman MH, Taylor SS",
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            ]
        },
        {
            "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.",
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            "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP",
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            "title": "O-GlcNAcylation is required for B cell homeostasis and antibody responses.",
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            "authors": "Lee BE, Kim HY, Kim HJ, Jeong H, Kim BG, Lee HE, Lee J, Kim HB, Lee SE, Yang YR, Yi EC, Hanover JA, Myung K, Suh PG, Kwon T, Kim JI",
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        {
            "title": "First comprehensive identification of cardiac proteins with putative increased O-GlcNAc levels during pressure overload hypertrophy.",
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            ]
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