{
    "uniprot_canonical_ac": "Q9CQV7-1",
    "uniprot_ac": "Q9CQV7",
    "uniprot_id": "TIM14_MOUSE",
    "mass": {
        "chemical_mass": 12437.0,
        "monoisotopic_mass": 12437.0
    },
    "refseq": {
        "ac": "NP_001273902",
        "name": "mitochondrial import inner membrane translocase subunit TIM14 isoform 4",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273902"
    },
    "gene_names": [
        {
            "name": "Dnajc19",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q9CQV7",
            "id": "Q9CQV7"
        },
        {
            "name": "1810055D05Rik; Tim14",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001021382",
            "id": "NP_001021382"
        },
        {
            "name": "Dnajc19",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001021382",
            "id": "NP_001021382"
        },
        {
            "name": "Tim14",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q9CQV7",
            "id": "Q9CQV7"
        },
        {
            "name": "Timm14",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q9CQV7",
            "id": "Q9CQV7"
        }
    ],
    "protein_names": [
        {
            "name": "Mitochondrial import inner membrane translocase subunit TIM14",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q9CQV7"
        },
        {
            "name": "DnaJ homolog subfamily C member 19",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q9CQV7"
        },
        {
            "name": "mitochondrial import inner membrane translocase subunit TIM14 isoform 2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001021382",
            "id": "NP_001021382"
        },
        {
            "name": "mitochondrial import inner membrane translocase subunit TIM14 isoform 4",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273902",
            "id": "NP_001273902"
        },
        {
            "name": "mitochondrial import inner membrane translocase subunit TIM14; DnaJ (Hsp40) homolog, subfamily C, member 19",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273902",
            "id": "NP_001273902"
        }
    ],
    "function": [
        {
            "annotation": "Mitochondrial co-chaperone which forms a complex with prohibitins to regulate cardiolipin remodeling (PubMed:24856930). May be a component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9CQV7",
                    "url": "https://www.uniprot.org/uniprot/Q9CQV7#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q07914",
                    "url": "https://www.uniprot.org/uniprot/Q07914#function"
                },
                {
                    "database": "PubMed",
                    "id": "24856930",
                    "url": "https://glygen.org/publication/PubMed/24856930"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:0110000",
            "recommended_name": {
                "id": "DOID:0110000",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0110000",
                "name": "3-methylglutaconic aciduria type 5",
                "description": "A 3-methylglutaconic aciduria that has_material_basis_in homozygous mutation in the DNAJC19 gene on chromosome 3q26."
            },
            "synonyms": [
                {
                    "id": "DOID:0110000",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0110000",
                    "name": "3-methylglutaconic aciduria type V",
                    "description": ""
                },
                {
                    "id": "DOID:0110000",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0110000",
                    "name": "DCMA",
                    "description": ""
                },
                {
                    "id": "DOID:0110000",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0110000",
                    "name": "DCMA syndrome",
                    "description": ""
                },
                {
                    "id": "DOID:0110000",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0110000",
                    "name": "MGA5",
                    "description": ""
                },
                {
                    "id": "DOID:0110000",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0110000",
                    "name": "MGCA5",
                    "description": ""
                },
                {
                    "id": "DOID:0110000",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0110000",
                    "name": "dilated cardiomyopathy with ataxia",
                    "description": ""
                },
                {
                    "id": "MONDO:0012435",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012435",
                    "name": "3-methylglutaconic aciduria type 5",
                    "description": "A syndrome characterized by severe early onset (before the age of three years) dilated cardiomyopathy (DCM) with conduction defects (long QT syndrome), non-progressive cerebellar ataxia, testicular dysgenesis, and 3-methylglutaconic aciduria."
                },
                {
                    "id": "MONDO:0012435",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012435",
                    "name": "3-methylglutaconic aciduria caused by mutation in DNAJC19",
                    "description": ""
                },
                {
                    "id": "MONDO:0012435",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012435",
                    "name": "3-methylglutaconic aciduria type 5",
                    "description": ""
                },
                {
                    "id": "MONDO:0012435",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012435",
                    "name": "3-methylglutaconic aciduria type V",
                    "description": ""
                },
                {
                    "id": "MONDO:0012435",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012435",
                    "name": "DCMA",
                    "description": ""
                },
                {
                    "id": "MONDO:0012435",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012435",
                    "name": "DCMA syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0012435",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012435",
                    "name": "DNAJC19 3-methylglutaconic aciduria",
                    "description": ""
                },
                {
                    "id": "MONDO:0012435",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012435",
                    "name": "MGA5",
                    "description": ""
                },
                {
                    "id": "MONDO:0012435",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012435",
                    "name": "MGCA5",
                    "description": ""
                },
                {
                    "id": "MONDO:0012435",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012435",
                    "name": "dilated cardiomyopathy with ataxia",
                    "description": ""
                },
                {
                    "id": "MONDO:0012435",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012435",
                    "name": "3 alpha methylglutaconic aciduria type V",
                    "description": ""
                },
                {
                    "id": "MONDO:0012435",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012435",
                    "name": "3 methylglutaconic aciduria type V",
                    "description": ""
                },
                {
                    "id": "MONDO:0012435",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012435",
                    "name": "3-METHYLGLUTACONIC aciduria, type V",
                    "description": ""
                },
                {
                    "id": "MONDO:0012435",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012435",
                    "name": "3-Methylglutaconic aciduria, type 5",
                    "description": ""
                },
                {
                    "id": "MONDO:0012435",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012435",
                    "name": "MGA 5",
                    "description": ""
                },
                {
                    "id": "MONDO:0012435",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012435",
                    "name": "MGA V",
                    "description": ""
                },
                {
                    "id": "MONDO:0012435",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012435",
                    "name": "Mga, type 5",
                    "description": ""
                },
                {
                    "id": "MONDO:0012435",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0012435",
                    "name": "cardiomyopathy, dilated, with ataxia",
                    "description": ""
                },
                {
                    "id": "MIM:610198",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/610198",
                    "name": "3-methylglutaconic aciduria 5",
                    "description": "3-methylglutaconic aciduria 5"
                }
            ],
            "evidence": [
                {
                    "id": "0110000",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0110000"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [
        {
            "start_pos": 90,
            "end_pos": 90,
            "sequence_org": "H",
            "sequence_mut": "Q",
            "comment": "Inhibits cell growth. No effect on interaction with PHB2.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9CQV7",
                    "url": "https://www.uniprot.org/uniprot/Q9CQV7"
                },
                {
                    "database": "PubMed",
                    "id": "24856930",
                    "url": "https://glygen.org/publication/PubMed/24856930"
                }
            ]
        }
    ],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9CQV7",
                    "url": "https://www.uniprot.org/uniprot/Q9CQV7"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Dnajc19",
            "url": "https://www.uniprot.org/uniprot/Q9CQV7",
            "locus": {
                "chromosome": "3",
                "start_pos": 34110169,
                "end_pos": 34135470,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000027679",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000027679"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000027679",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000027679",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "cd06257",
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06257",
            "database": "CDD",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "67713",
            "url": "https://www.ncbi.nlm.nih.gov/gene/67713",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR001623",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001623",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR036869",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036869",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:67713",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:67713",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "1914963",
            "url": "http://www.informatics.jax.org/marker/MGI:1914963",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "RQMPNAA",
            "url": "https://omabrowser.org/oma/group/RQMPNAA/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "160310at2759",
            "url": "http://www.orthodb.org/?query=160310at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR12763",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12763",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR12763:SF56",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12763:SF56",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF00226",
            "url": "http://pfam.xfam.org/family/PF00226",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q9CQV7",
            "url": "http://purl.obolibrary.org/obo/PR_Q9CQV7",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_001021382",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001021382",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "D3Z5K6",
            "url": "https://www.uniprot.org/uniprot/D3Z5K6",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "D3Z5K6-1",
            "url": "https://www.uniprot.org/uniprot/D3Z5K6-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "G3X8S1",
            "url": "https://www.uniprot.org/uniprot/G3X8S1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "G3X8S1-1",
            "url": "https://www.uniprot.org/uniprot/G3X8S1-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q9CQV7",
            "url": "https://www.uniprot.org/uniprot/Q9CQV7",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q9CQV7-1",
            "url": "https://www.uniprot.org/uniprot/Q9CQV7-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q9CQV7-2",
            "url": "https://www.uniprot.org/uniprot/Q9CQV7-2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q9CQV7-3",
            "url": "https://www.uniprot.org/uniprot/Q9CQV7-3",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MASTVVAVGLTIAAAGFAGRYVLQAMKHVEPQVKQVFQSLPKSAFGGGYYRGGFEPKMTKREAALILGVSPTANKGKIRDAHRRIMLLNHPDKGGSPYIAAKINEAKDLLEGQAKK",
        "length": 116,
        "header": "sp|Q9CQV7-1|TIM14_MOUSE Isoform 1 of Mitochondrial import inner membrane translocase subunit TIM14  OS=Mus musculus OX=10090 GN=Dnajc19 PE=1 SV=3 CANONICAL=Q9CQV7-1"
    },
    "isoforms": [
        {
            "isoform_ac": "D3Z5K6-1",
            "url": "",
            "sequence": {
                "sequence": "MSARCRAAEWSHGRYVLQAMKHVEPQVKQVFQSLPKSAFGGGYYRGGFEPKMTKREAALILGVSPTANKGKIRDAHRRIMLLNHPDKGGSPYIAAKINEAKDLLEGQAKK",
                "length": 110,
                "header": "tr|D3Z5K6-1|D3Z5K6_MOUSE Computationally mapped isoform of DnaJ heat shock protein family (Hsp40) member C19  OS=Mus musculus OX=10090 GN=Dnajc19 PE=1 SV=1 CANONICAL=Q9CQV7-1"
            },
            "locus": {
                "chromosome": "3",
                "start_pos": 34135371,
                "end_pos": 34131606,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000120805.8",
                        "url": "https://www.ensembl.org/id/ENSMUST00000120805.8"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000113514.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000113514.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "G3X8S1-1",
            "url": "",
            "sequence": {
                "sequence": "MASTVVAVGLTIAAAGFAGRYVLQAMKHVEPQVKQVFQSLPKSAFGGGYYRGGFEPKMTKREAALILGVSPTANKGKIRDAHRRIMLLNHPDKGPLVEEGLKPIPICRSCSSICRRSILSCSTSYDQNKNPFTVCVCVHSRAHTGIHTPVKPCETTM",
                "length": 157,
                "header": "tr|G3X8S1-1|TIM14_MOUSE Computationally mapped isoform of Mitochondrial import inner membrane translocase subunit TIM14  OS=Mus musculus OX=10090 GN=Dnajc19 PE=1 SV=1 CANONICAL=Q9CQV7-1"
            },
            "locus": {
                "chromosome": "3",
                "start_pos": 34135337,
                "end_pos": 34112073,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000011029.12",
                        "url": "https://www.ensembl.org/id/ENSMUST00000011029.12"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000011029.6",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000011029.6"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q9CQV7-1",
            "url": "",
            "sequence": {
                "sequence": "MASTVVAVGLTIAAAGFAGRYVLQAMKHVEPQVKQVFQSLPKSAFGGGYYRGGFEPKMTKREAALILGVSPTANKGKIRDAHRRIMLLNHPDKGGSPYIAAKINEAKDLLEGQAKK",
                "length": 116,
                "header": "sp|Q9CQV7-1|TIM14_MOUSE Isoform 1 of Mitochondrial import inner membrane translocase subunit TIM14  OS=Mus musculus OX=10090 GN=Dnajc19 PE=1 SV=3 CANONICAL=Q9CQV7-1"
            },
            "locus": {
                "chromosome": "3",
                "start_pos": 34135337,
                "end_pos": 34131606,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000108195",
                        "url": "https://www.ensembl.org/id/ENSMUST00000108195"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000103830",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000103830"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q9CQV7-2",
            "url": "",
            "sequence": {
                "sequence": "MASTVVAVGLTIAAAGFAGRYVLQAMKHVEPQVKQVFQSLPKSAFGGGYYRGGFEPKMTKREAALILGVSPTANKGKIRDAHRRIMLLNHPDKGPLVEEGLKPIPICRSCSSICRRSILSCSTSYDQNKNPFTVCVCVHSSAHTGIHTPVKPCETTM",
                "length": 157,
                "header": "sp|Q9CQV7-2|TIM14_MOUSE Isoform 2 of Mitochondrial import inner membrane translocase subunit TIM14  OS=Mus musculus OX=10090 GN=Dnajc19 PE=1 SV=3 CANONICAL=Q9CQV7-1"
            },
            "locus": {}
        },
        {
            "isoform_ac": "Q9CQV7-3",
            "url": "",
            "sequence": {
                "sequence": "MASTVVAVGLTIAAAGFAGRYVLQAMKHVEPQVKQVFQSLPKSAFGGGYYRGGFEPKMTKREAALILGVSPTANKGKIRDAHRRIMLLNHPDKGKQLLLLYWTVNGIANSWCYECLCVSSFPVVDHIVVS",
                "length": 130,
                "header": "sp|Q9CQV7-3|TIM14_MOUSE Isoform 3 of Mitochondrial import inner membrane translocase subunit TIM14  OS=Mus musculus OX=10090 GN=Dnajc19 PE=1 SV=3 CANONICAL=Q9CQV7-1"
            },
            "locus": {
                "chromosome": "3",
                "start_pos": 34135337,
                "end_pos": 34132814,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000117223",
                        "url": "https://www.ensembl.org/id/ENSMUST00000117223"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000113484",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000113484"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 39,
            "end_pos": 39,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q9CQV7",
                    "url": "https://www.uniprot.org/uniprot/Q9CQV7"
                }
            ],
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        {
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                    "database": "UniProtKB",
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                    "url": "https://www.uniprot.org/uniprot/Q9CQV7"
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            "site_lbl": "Ser70"
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        {
            "title": "DNAJC19, a mitochondrial cochaperone associated with cardiomyopathy, forms a complex with prohibitins to regulate cardiolipin remodeling.",
            "journal": "Cell Metab.",
            "date": "2014",
            "authors": "Richter-Dennerlein R, Korwitz A, Haag M, Tatsuta T, Dargazanli S, Baker M, Decker T, Lamkemeyer T, Rugarli EI, Langer T",
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                    "type": "PubMed",
                    "id": "24856930",
                    "url": "https://glygen.org/publication/PubMed/24856930"
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            ]
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            "name": "",
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