{ "uniprot_canonical_ac": "Q9CQN7-1", "uniprot_ac": "Q9CQN7", "uniprot_id": "RM41_MOUSE", "mass": { "chemical_mass": 15262.0, "monoisotopic_mass": 15262.0 }, "refseq": { "ac": "NP_001026978", "name": "large ribosomal subunit protein mL41 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026978" }, "gene_names": [ { "name": "Mrpl41", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q9CQN7", "id": "Q9CQN7" }, { "name": "MRP-L27; Rpml27", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026978", "id": "NP_001026978" }, { "name": "Mrpl41", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026978", "id": "NP_001026978" } ], "protein_names": [ { "name": "Large ribosomal subunit protein mL41", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q9CQN7" }, { "name": "39S ribosomal protein L41, mitochondrial; L41mt; MRP-L41; large ribosomal subunit protein mL41", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026978", "id": "NP_001026978" }, { "name": "39S ribosomal protein L41, mitochondrial", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9CQN7" }, { "name": "L41mt", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9CQN7" }, { "name": "MRP-L41", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9CQN7" }, { "name": "large ribosomal subunit protein mL41 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026978", "id": "NP_001026978" } ], "function": [ { "annotation": "Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins.", "evidence": [ { "database": "UniProtKB", "id": "Q9CQN7", "url": "https://www.uniprot.org/uniprot/Q9CQN7#function" }, { "database": "UniProtKB", "id": "Q8IXM3", "url": "https://www.uniprot.org/uniprot/Q8IXM3#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q9CQN7", "url": "https://www.uniprot.org/uniprot/Q9CQN7" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Mrpl41", "url": "https://www.uniprot.org/uniprot/Q9CQN7", "locus": { "chromosome": "2", "start_pos": 24864129, "end_pos": 24865110, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000036850", "url": "https://www.ensembl.org/id/ENSMUSG00000036850" } ] } } ], "crossref": [ { "id": "ENSMUSG00000036850", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000036850", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "107733", "url": "https://www.ncbi.nlm.nih.gov/gene/107733", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR019189", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019189", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:107733", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:107733", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1333816", "url": "http://www.informatics.jax.org/marker/MGI:1333816", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "KFVQVKE", "url": "https://omabrowser.org/oma/group/KFVQVKE/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "9263at2759", "url": "http://www.orthodb.org/?query=9263at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR21338", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21338", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR21338:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21338:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF09809", "url": "http://pfam.xfam.org/family/PF09809", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q9CQN7", "url": "http://purl.obolibrary.org/obo/PR_Q9CQN7", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-5389840", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5389840", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-5419276", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5419276", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001026978", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026978", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A0A6YXF9", "url": "https://www.uniprot.org/uniprot/A0A0A6YXF9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0A6YXF9-1", "url": "https://www.uniprot.org/uniprot/A0A0A6YXF9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9CQN7", "url": "https://www.uniprot.org/uniprot/Q9CQN7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9CQN7-1", "url": "https://www.uniprot.org/uniprot/Q9CQN7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGFLTAVTQGLVRGADRMSKWTSKRGPRTFTKSRGAKKTGIYTSDRKFVQIKEMVPEFVVPDLTGFKLKPYVNYRAPAGIDTPLTAKALFQETVAPAIEKDFKEGTFDANNLEKYGFEPTQEGKLFQLYPKNFPR", "length": 135, "header": "sp|Q9CQN7-1|RM41_MOUSE Isoform 1 of Large ribosomal subunit protein mL41 OS=Mus musculus OX=10090 GN=Mrpl41 PE=1 SV=1 CANONICAL=Q9CQN7-1" }, "isoforms": [ { "isoform_ac": "A0A0A6YXF9-1", "url": "", "sequence": { "sequence": "MSVSSWRHLHGLLRGPGSFRAGPLRPWLLVSSAPTELIYPEPSMGFLTAVTQGLVRGADRMSKWTSKRGPRTFTKSRGAKKTGIYTSDRKFVQIKEM", "length": 97, "header": "tr|A0A0A6YXF9-1|RM41_MOUSE Computationally mapped isoform of Large ribosomal subunit protein mL41 OS=Mus musculus OX=10090 GN=Mrpl41 PE=1 SV=5 CANONICAL=Q9CQN7-1" }, "locus": { "chromosome": "2", "start_pos": 24864893, "end_pos": 24864509, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000194392.2", "url": "https://www.ensembl.org/id/ENSMUST00000194392.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000141974.2", "url": "https://www.ensembl.org/id/ENSMUSP00000141974.2" } ] } }, { "isoform_ac": "Q9CQN7-1", "url": "", "sequence": { "sequence": "MGFLTAVTQGLVRGADRMSKWTSKRGPRTFTKSRGAKKTGIYTSDRKFVQIKEMVPEFVVPDLTGFKLKPYVNYRAPAGIDTPLTAKALFQETVAPAIEKDFKEGTFDANNLEKYGFEPTQEGKLFQLYPKNFPR", "length": 135, "header": "sp|Q9CQN7-1|RM41_MOUSE Isoform 1 of Large ribosomal subunit protein mL41 OS=Mus musculus OX=10090 GN=Mrpl41 PE=1 SV=1 CANONICAL=Q9CQN7-1" }, "locus": { "chromosome": "2", "start_pos": 24864670, "end_pos": 24864266, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000045604", "url": "https://www.ensembl.org/id/ENSMUST00000045604" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000043561", "url": "https://www.ensembl.org/id/ENSMUSP00000043561" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [], "pathway": [ { "id": "mmu:107733", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:107733", "resource": "KEGG Pathway" }, { "id": "R-MMU-5389840", "name": "Mitochondrial translation elongation", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5389840", "resource": "Reactome", "description": "Mitochondrial translation elongation" }, { "id": "R-MMU-5419276", "name": "Mitochondrial translation termination", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5419276", "resource": 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