{ "uniprot_canonical_ac": "Q9BYZ8-1", "uniprot_ac": "Q9BYZ8", "uniprot_id": "REG4_HUMAN", "mass": { "chemical_mass": 18230.0, "monoisotopic_mass": 18230.0 }, "refseq": { "ac": "NP_001152824", "name": "regenerating islet-derived protein 4 isoform 1 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152824" }, "gene_names": [ { "name": "REG4", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q9BYZ8", "id": "Q9BYZ8" }, { "name": "GISP; REG-IV; RELP", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152824", "id": "NP_001152824" }, { "name": "GISP", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9BYZ8", "id": "Q9BYZ8" }, { "name": "REG4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152824", "id": "NP_001152824" }, { "name": "RELP", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9BYZ8", "id": "Q9BYZ8" } ], "protein_names": [ { "name": "Regenerating islet-derived protein 4", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q9BYZ8" }, { "name": "Gastrointestinal secretory protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9BYZ8" }, { "name": "REG-4", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9BYZ8" }, { "name": "REG-like protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9BYZ8" }, { "name": "Reg IV", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9BYZ8" }, { "name": "Regenerating islet-derived protein IV", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9BYZ8" }, { "name": "regenerating gene type IV; gastrointestinal secretory protein; regenerating islet-derived protein 4; REG-4; reg IV; REG-like protein; regenerating islet-derived protein IV; regenerating islet-derived family, member 4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152824", "id": "NP_001152824" }, { "name": "regenerating islet-derived protein 4 isoform 1 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152824", "id": "NP_001152824" } ], "function": [ { "annotation": "Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium.", "evidence": [ { "database": "UniProtKB", "id": "Q9BYZ8", "url": "https://www.uniprot.org/uniprot/Q9BYZ8#function" }, { "database": "PubMed", "id": "20692269", "url": "https://glygen.org/publication/PubMed/20692269" }, { "database": "PubMed", "id": "12819006", "url": "https://glygen.org/publication/PubMed/12819006" } ] }, { "annotation": "Clinicopathological Significance and Prognostic Implications of REG4 Immunohistochemical Expression in Colorectal Cancer. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001152824", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152824" }, { "database": "PubMed", "id": "34577861", "url": "https://glygen.org/publication/PubMed/34577861" } ] }, { "annotation": "Overexpression of Reg IV may be an early event in colorectal carcinogenesis.", "evidence": [ { "database": "RefSeq", "id": "NP_001152824", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152824" }, { "database": "PubMed", "id": "14550954", "url": "https://glygen.org/publication/PubMed/14550954" } ] }, { "annotation": "Reg4 Interacts with CD44 to Regulate Proliferation and Stemness of Colorectal and Pancreatic Cancer Cells.", "evidence": [ { "database": "RefSeq", "id": "NP_001152824", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152824" }, { "database": "PubMed", "id": "34753802", "url": "https://glygen.org/publication/PubMed/34753802" } ] }, { "annotation": "Regenerating gene 4 promotes chemoresistance of colorectal cancer by affecting lipid droplet synthesis and assembly.", "evidence": [ { "database": "RefSeq", "id": "NP_001152824", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152824" }, { "database": "PubMed", "id": "37744296", "url": "https://glygen.org/publication/PubMed/37744296" } ] }, { "annotation": "Results suggest that RELP might be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium.", "evidence": [ { "database": "RefSeq", "id": "NP_001152824", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152824" }, { "database": "PubMed", "id": "12819006", "url": "https://glygen.org/publication/PubMed/12819006" } ] }, { "annotation": "The effects of REG4 expression on chemoresistance of ovarian cancer.", "evidence": [ { "database": "RefSeq", "id": "NP_001152824", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152824" }, { "database": "PubMed", "id": "35929918", "url": "https://glygen.org/publication/PubMed/35929918" } ] }, { "annotation": "Upregulation of REG IV gene in human intestinal epithelial cells by lipopolysaccharide via downregulation of microRNA-24.", "evidence": [ { "database": "RefSeq", "id": "NP_001152824", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152824" }, { "database": "PubMed", "id": "35946046", "url": "https://glygen.org/publication/PubMed/35946046" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs750870106", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs750870106" }, { "id": "rs750870106", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs750870106" }, { "id": "rs750870106", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs750870106#frequency_tab" }, { "id": "rs750870106", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs750870106" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 139, "end_pos": 139, "sequence_org": "L", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NFL->NFS).", "chr_id": "1", "chr_pos": "119794679", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "L139", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs779339293", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs779339293" }, { "id": "rs779339293", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs779339293" }, { "id": "rs779339293", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs779339293" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 140, "end_pos": 140, "sequence_org": "T", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (TWS->NWS).", "chr_id": "1", "chr_pos": "119794676", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T140", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1412294829", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1412294829" }, { "id": "rs1412294829", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1412294829#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 50, "end_pos": 50, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NWS->SWS).", "chr_id": "1", "chr_pos": "119803084", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N50", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "Q9BYZ8", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BYZ8" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 52, "end_pos": 52, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "S", "sequence_mut": "Y", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-loss (NWS->NWY).", "chr_id": "1", "chr_pos": "119803078", "ref_nt": "G", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "S52", "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": 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"database": "Bgee", "id": "ENSG00000134193", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000134193" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "47.64", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000134193", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000134193" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "33.46", "present": "ABSENT", "evidence": [ { "database": "Bgee", "id": "ENSG00000134193", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000134193" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "35.92", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000134193", "url": 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"https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "No", "trend": "up", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "Q9BYZ8", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q9BYZ8" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "Q9BYZ8", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q9BYZ8" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", 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"malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9BYZ8", "url": "https://www.uniprot.org/uniprot/Q9BYZ8" } ], "common_name": "Human" } ], "gene": [ { "name": "REG4", "url": "https://www.uniprot.org/uniprot/Q9BYZ8", "locus": { "chromosome": "1", "start_pos": 119794017, "end_pos": 119811580, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000134193", "url": "https://www.ensembl.org/id/ENSG00000134193" } ] } } ], "crossref": [ { "id": "ENSG00000134193", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000134193", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "Q9BYZ8", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q9BYZ8", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "cd03594", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03594", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "REG4", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=REG4", "database": "GeneCards", "categories": [ "Organism-specific", "Gene Annotation" ] }, { "id": "83998", "url": "https://www.ncbi.nlm.nih.gov/gene/83998", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "22977", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=22977", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "Q9BYZ8", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q9BYZ8*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001304", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001304", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016186", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016186", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016187", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016187", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018378", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018378", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:83998", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:83998", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "609846", "url": "http://www.omim.org/entry/609846", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_Q9BYZ8", "url": "https://www.nextprot.org/entry/NX_Q9BYZ8", "database": "neXtProt", "categories": [ "Organism-specific", "Protein" ] }, { "id": "WNSNECN", "url": "https://omabrowser.org/oma/group/WNSNECN/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2906734at2759", "url": "http://www.orthodb.org/?query=2906734at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22803", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22803", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22803:SF147", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22803:SF147", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "2KV3", "url": "https://www.rcsb.org/structure/2KV3", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00059", "url": "http://pfam.xfam.org/family/PF00059", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "Q9BYZ8", "url": "https://pharos.nih.gov/targets/Q9BYZ8", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_Q9BYZ8", "url": "http://purl.obolibrary.org/obo/PR_Q9BYZ8", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001152824", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152824", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "E9PNV6", "url": "https://www.uniprot.org/uniprot/E9PNV6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9PNV6-1", "url": "https://www.uniprot.org/uniprot/E9PNV6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9BYZ8", "url": "https://www.uniprot.org/uniprot/Q9BYZ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9BYZ8-1", "url": "https://www.uniprot.org/uniprot/Q9BYZ8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q9BYZ8-2", "url": "https://www.uniprot.org/uniprot/Q9BYZ8-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MASRSMRLLLLLSCLAKTGVLGDIIMRPSCAPGWFYHKSNCYGYFRKLRNWSDAELECQSYGNGAHLASILSLKEASTIAEYISGYQRSQPIWIGLHDPQKRQQWQWIDGAMYLYRSWSGKSMGGNKHCAEMSSNNNFLTWSSNECNKRQHFLCKYRP", "length": 158, "header": "sp|Q9BYZ8-1|REG4_HUMAN Isoform 1 of Regenerating islet-derived protein 4 OS=Homo sapiens OX=9606 GN=REG4 PE=1 SV=1 CANONICAL=Q9BYZ8-1" }, "isoforms": [ { "isoform_ac": "E9PNV6-1", "url": "", "sequence": { "sequence": "MASRSMRLLLLLSCLAKTGVLGDIIMRPSCAPGWFYHKSNCYGYFRKLRNWSDAELECQSYGNGAHLASILSLKEASTIAEYISGYQRSQPIWIGLHDPQKTF", "length": 103, "header": "tr|E9PNV6-1|E9PNV6_HUMAN Computationally mapped isoform of Regenerating family member 4 OS=Homo sapiens OX=9606 GN=REG4 PE=1 SV=1 CANONICAL=Q9BYZ8-1" }, "locus": { "chromosome": "1", "start_pos": 119808769, "end_pos": 119794680, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000530654.1", "url": "https://www.ensembl.org/id/ENST00000530654.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000437135.1", "url": "https://www.ensembl.org/id/ENSP00000437135.1" } ] } }, { "isoform_ac": "Q9BYZ8-1", "url": "", "sequence": { "sequence": "MASRSMRLLLLLSCLAKTGVLGDIIMRPSCAPGWFYHKSNCYGYFRKLRNWSDAELECQSYGNGAHLASILSLKEASTIAEYISGYQRSQPIWIGLHDPQKRQQWQWIDGAMYLYRSWSGKSMGGNKHCAEMSSNNNFLTWSSNECNKRQHFLCKYRP", "length": 158, "header": "sp|Q9BYZ8-1|REG4_HUMAN Isoform 1 of Regenerating islet-derived protein 4 OS=Homo sapiens OX=9606 GN=REG4 PE=1 SV=1 CANONICAL=Q9BYZ8-1" }, "locus": { "chromosome": "1", "start_pos": 119808769, "end_pos": 119794621, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000354219.5", "url": "https://www.ensembl.org/id/ENST00000354219.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000346158.1", "url": "https://www.ensembl.org/id/ENSP00000346158.1" } ] } }, { "isoform_ac": "Q9BYZ8-2", "url": "", "sequence": { "sequence": "MASRSMRLLLLLSCLAKTGVLGDIIMRPSCAPGWFYHKSNCYGYFRKLRNWSDAEVRNLLPAWPGLSRAKDQPEPQISFDSGSSVLPGHYEEKPLWLVKWREEGCVFNSFNSVSIAEAGAVCQTLDGLQAHTDT", "length": 134, "header": "sp|Q9BYZ8-2|REG4_HUMAN Isoform 2 of Regenerating islet-derived protein 4 OS=Homo sapiens OX=9606 GN=REG4 PE=1 SV=1 CANONICAL=Q9BYZ8-1" }, "locus": { "chromosome": "1", "start_pos": 119808769, "end_pos": 119802831, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000369401.4", "url": "https://www.ensembl.org/id/ENST00000369401.4" }, { "database": "Ensembl Peptide", "id": "ENSP00000358409.4", "url": "https://www.ensembl.org/id/ENSP00000358409.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 50, "start_aa": "Asn", "end_pos": 50, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn50", "evidence": [ { "id": "Q9BYZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BYZ8#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Isolation and characterization of a cDNA encoding a novel member of the human regenerating protein family: Reg IV.", "journal": "Biochim. Biophys. Acta", "date": "2001", "authors": "Zhang H., Soares M.B., Bonaldo M.F., Dieckgraefe B.K., Hartupee J.C.", "evidence": [ { "database": "UniProtKB", "id": "Q9BYZ8", "url": "https://www.uniprot.org/uniprot/Q9BYZ8" } ], "reference": [ { "type": "PubMed", "id": "11311942", "url": "https://glygen.org/publication/PubMed/11311942" } ] }, { "title": "Reg IV, a new member of the regenerating gene family, is overexpressed in colorectal carcinomas.", "journal": "Int. J. Cancer", "date": "2003", "authors": "Violette S, Festor E, Pandrea-Vasile I, Mitchell V, Adida C, Dussaulx E, Lacorte JM, Chambaz J, Lacasa M, Lesuffleur T", "evidence": [ { "database": "UniProtKB", "id": "Q9BYZ8", "url": "https://www.uniprot.org/uniprot/Q9BYZ8" } ], "reference": [ { "type": "PubMed", "id": "12455032", "url": "https://glygen.org/publication/PubMed/12455032" } ] }, { "title": "RELP, a novel human REG-like protein with up-regulated expression in inflammatory and metaplastic gastrointestinal mucosa.", "journal": "Am. J. Pathol.", "date": "2003", "authors": "Kamarainen M, Heiskala K, Knuutila S, Heiskala M, Winqvist O, Andersson LC", "evidence": [ { "database": "UniProtKB", "id": "Q9BYZ8", "url": "https://www.uniprot.org/uniprot/Q9BYZ8" }, { "database": "RefSeq", "id": "NP_001152824", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152824" } ], "reference": [ { "type": "PubMed", "id": "12819006", "url": "https://glygen.org/publication/PubMed/12819006" } ] }, { "title": "Overexpression of Reg IV in colorectal adenoma.", "journal": "Cancer letters", "date": "2003", "authors": "Zhang Y, Lai M, Lv B, Gu X, Wang H, Zhu Y, Zhu Y, Shao L, Wang G", "evidence": [ { "database": "RefSeq", "id": "NP_001152824", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152824" } ], "reference": [ { "type": "PubMed", "id": "14550954", "url": "https://glygen.org/publication/PubMed/14550954" } ] }, { "title": "Signal peptide prediction based on analysis of experimentally verified cleavage sites.", "journal": "Protein Sci.", "date": "2004", "authors": "Zhang Z, Henzel WJ", "evidence": [ { "database": "UniProtKB", "id": "Q9BYZ8", "url": "https://www.uniprot.org/uniprot/Q9BYZ8" } ], "reference": [ { "type": "PubMed", "id": "15340161", "url": "https://glygen.org/publication/PubMed/15340161" } ] }, { "title": "Human RegIV protein adopts a typical C-type lectin fold but binds mannan with two calcium-independent sites.", "journal": "J. Mol. Biol.", "date": "2010", "authors": "Ho MR, Lou YC, Wei SY, Luo SC, Lin WC, Lyu PC, Chen C", "evidence": [ { "database": "UniProtKB", "id": "Q9BYZ8", "url": "https://www.uniprot.org/uniprot/Q9BYZ8" } ], "reference": [ { "type": "PubMed", "id": "20692269", "url": "https://glygen.org/publication/PubMed/20692269" } ] }, { "title": "REG4 Is Highly Expressed in Mucinous Ovarian Cancer: A Potential Novel Serum Biomarker.", "journal": "PloS one", "date": "2016", "authors": "Lehtinen L, Vesterkvist P, Roering P, Korpela T, Hattara L, Kaipio K, Mpindi JP, Hynninen J, Auranen A, Davidson B, Haglund C, Iljin K, Grenman S, Siitari H, Carpen O", "evidence": [ { "database": "GlyGen", "id": "A0298", "url": "https://data.glygen.org/GLY_000625" } ], "reference": [ { "type": "PubMed", "id": "26981633", "url": "https://glygen.org/publication/PubMed/26981633" } ] }, { "title": "REG4 promotes peritoneal metastasis of gastric cancer through GPR37.", "journal": "Oncotarget", "date": "2016", "authors": "Wang H, Hu L, Zang M, Zhang B, Duan Y, Fan Z, Li J, Su L, Yan M, Zhu Z, Liu B, Yang Q", "evidence": [ { "database": "GlyGen", "id": "A0298", "url": "https://data.glygen.org/GLY_000625" } ], "reference": [ { "type": "PubMed", "id": "27036049", "url": "https://glygen.org/publication/PubMed/27036049" } ] }, { "title": "Clinicopathological Significance and Prognostic Implications of REG4 Immunohistochemical Expression in Colorectal Cancer.", "journal": "Medicina (Kaunas, Lithuania)", "date": "2021", "authors": "Kang G, Oh I, Pyo J, Kang D, Son B", "evidence": [ { "database": "RefSeq", "id": "NP_001152824", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152824" } ], "reference": [ { "type": "PubMed", "id": "34577861", "url": "https://glygen.org/publication/PubMed/34577861" } ] }, { "title": "Reg4 Interacts with CD44 to Regulate Proliferation and Stemness of Colorectal and Pancreatic Cancer Cells.", "journal": "Molecular cancer research : MCR", "date": "2022", "authors": "Bishnupuri KS, Sainathan SK, Ciorba MA, Houchen CW, Dieckgraefe BK", "evidence": [ { "database": "RefSeq", "id": "NP_001152824", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152824" } ], "reference": [ { "type": "PubMed", "id": "34753802", "url": "https://glygen.org/publication/PubMed/34753802" } ] }, { "title": "The effects of REG4 expression on chemoresistance of ovarian cancer.", "journal": "Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology", "date": "2022-08-05", "authors": "Xiang Li-Wei, Xue Hang, Ha Min-Wen, Yu Da-Yong, Xiao Li-Jun, Zheng Hua-Chuan", "evidence": [ { "database": "RefSeq", "id": "NP_001152824", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152824" } ], "reference": [ { "type": "PubMed", "id": "35929918", "url": "https://glygen.org/publication/PubMed/35929918" } ] }, { "title": "Upregulation of REG IV gene in human intestinal epithelial cells by lipopolysaccharide via downregulation of microRNA-24.", "journal": "Journal of cellular and molecular medicine", "date": "2022", "authors": "Takasawa S, Tsuchida C, Sakuramoto-Tsuchida S, Uchiyama T, Makino M, Yamauchi A, Itaya-Hironaka A", "evidence": [ { "database": "RefSeq", "id": "NP_001152824", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152824" } ], "reference": [ { "type": "PubMed", "id": "35946046", "url": "https://glygen.org/publication/PubMed/35946046" } ] }, { "title": "Regenerating gene 4 promotes chemoresistance of colorectal cancer by affecting lipid droplet synthesis and assembly.", "journal": "World journal of gastroenterology", "date": "2023-09-21", "authors": "Zhang Cong-Yu, Zhang Rui, Zhang Li, Wang Zi-Mo, Sun Hong-Zhi, Cui Zheng-Guo, Zheng Hua-Chuan", "evidence": [ { "database": "RefSeq", "id": "NP_001152824", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152824" } ], "reference": [ { "type": "PubMed", "id": "37744296", "url": "https://glygen.org/publication/PubMed/37744296" } ] } ], "pathway": [ { "id": "hsa:83998", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:83998", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q68AX7-1", "protein_name": "Regenerating islet-derived protein 4", "gene_name": "Reg4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASKCVRLLLLLSWVAGPEVLSDILRPSCASGWFNYRSHCYGYFRKLRNWSHAELECQSYGNGSHLASVLNPKEASVISKYITGYQRSLPVWIGLHDPQKNASWQWIDGSTNQYRPWSPRTKSEARHCTEMNPKDKFLTWNKNGCTKRQHFLCKYRP", "length": 157 }, "evidence": [ { "id": "45225755", "url": "http://www.informatics.jax.org/homology/45225755", "database": "MGI" }, { "id": "Q9BYZ8", "url": "https://omabrowser.org/oma/group/Q9BYZ8/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9D8G5-1", "protein_name": "Regenerating islet-derived protein 4", "gene_name": "Reg4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASKGVRLLLLLSWVAGPEVLSDILRPSCAPGWFYYRSHCYGYFRKLRNWSHAELECQSYGNGSHLASVLNQKEASVISKYITGYQRNLPVWIGLHDPQKKQLWQWTDGSTNLYRRWNPRTKSEARHCAEMNPKDKFLTWNKNGCANRQHFLCKYKT", "length": 157 }, "evidence": [ { "id": "45225755", "url": "http://www.informatics.jax.org/homology/45225755", "database": "MGI" }, { "id": "Q9BYZ8", "url": "https://omabrowser.org/oma/group/Q9BYZ8/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "Q9BYZ8", "url": "https://www.uniprot.org/uniprot/Q9BYZ8" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q9BYZ8", "url": "https://www.uniprot.org/uniprot/Q9BYZ8" } ], "pmid": "" } ] }, { "name": "Molecular Function", 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