{ "uniprot_canonical_ac": "Q9BRG2-1", "uniprot_ac": "Q9BRG2", "uniprot_id": "SH23A_HUMAN", "mass": { "chemical_mass": 63093.0, "monoisotopic_mass": 63093.0 }, "refseq": { "ac": "NP_005481", "name": "SH2 domain-containing protein 3A isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005481" }, "gene_names": [ { "name": "SH2D3A", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q9BRG2", "id": "Q9BRG2" }, { "name": "NSP1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005481", "id": "NP_005481" }, { "name": "NSP1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9BRG2", "id": "Q9BRG2" }, { "name": "PRO201", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q9BRG2", "id": "Q9BRG2" }, { "name": "SH2D3A", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005481", "id": "NP_005481" } ], "protein_names": [ { "name": "SH2 domain-containing protein 3A", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q9BRG2" }, { "name": "Novel SH2-containing protein 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q9BRG2" }, { "name": "SH2 domain-containing protein 3A isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005481", "id": "NP_005481" }, { "name": "novel SH2-containing protein 1; SH2 domain-containing protein 3A", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005481", "id": "NP_005481" } ], "function": [ { "annotation": "May play a role in JNK activation.", "evidence": [ { "database": "UniProtKB", "id": "Q9BRG2", "url": "https://www.uniprot.org/uniprot/Q9BRG2#function" } ] }, { "annotation": "NSP1 and BCAR3 are more highly expressed than SH2D3C (SHEP1) in breast cancer cells, and the expression patterns suggest differential roles for the three genes during breast cancer progression.", "evidence": [ { "database": "RefSeq", "id": "NP_005481", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005481" }, { "database": "PubMed", "id": "17270363", "url": "https://glygen.org/publication/PubMed/17270363" } ] }, { "annotation": "NSP1 overexpression did not induce anti-estrogen resistance in breast tumor cell lines.", "evidence": [ { "database": "RefSeq", "id": "NP_005481", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005481" }, { "database": "PubMed", "id": "17427198", "url": "https://glygen.org/publication/PubMed/17427198" } ] }, { "annotation": "Nsp1 proteins of human coronaviruses HCoV-OC43 and SARS-CoV2 inhibit stress granule formation. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_005481", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005481" }, { "database": "PubMed", "id": "36534661", "url": "https://glygen.org/publication/PubMed/36534661" } ] } ], "disease": [], "snv": [], "mutagenesis": [ { "start_pos": 231, "end_pos": 231, "sequence_org": "Y", "sequence_mut": "F", "comment": "Weak phosphorylation.", "evidence": [ { "database": "UniProtKB", "id": "Q9BRG2", "url": "https://www.uniprot.org/uniprot/Q9BRG2" }, { "database": "PubMed", "id": "10187783", "url": "https://glygen.org/publication/PubMed/10187783" } ] }, { "start_pos": 95, "end_pos": 95, "sequence_org": "Y", "sequence_mut": "F", "comment": "Loss of phosphorylation.", "evidence": [ { "database": "UniProtKB", "id": "Q9BRG2", "url": "https://www.uniprot.org/uniprot/Q9BRG2" }, { "database": "PubMed", "id": "10187783", "url": "https://glygen.org/publication/PubMed/10187783" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "76.29", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000125731", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000125731" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "76.43", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000125731", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000125731" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "81.03", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000125731", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000125731" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "89.8", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000125731", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000125731" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "68.48", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000125731", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000125731" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "83.19", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000125731", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000125731" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "75.3", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000125731", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000125731" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "77.04", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000125731", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000125731" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "85.46", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000125731", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000125731" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "74.33", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000125731", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000125731" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "67.2", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000125731", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000125731" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "90.54", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000125731", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000125731" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "83.36", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000125731", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000125731" } ] } ], "expression_disease": [ { "significant": "No", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "Q9BRG2", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q9BRG2" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": 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"url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", 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developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { 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"MQVPQDGEDLAGQPWYHGLLSRQKAEALLQQNGDFLVRASGSRGGNPVISCRWRGSALHFEVFRVALRPRPGRPTALFQLEDEQFPSIPALVHSYMTGRRPLSQATGAVVSRPVTWQGPLRRSFSEDTLMDGPARIEPLRARKWSNSQPADLAHMGRSREDPAGMEASTMPISALPRTSSDPVLLKAPAPLGTVADSLRASDGQLQAKAPTKPPRTPSFELPDASERPPTYCELVPRVPSVQGTSPSQSCPEPEAPWWEAEEDEEEENRCFTRPQAEISFCPHDAPSCLLGPQNRPLEPQVLHTLRGLFLEHHPGSTALHLLLVDCQATGLLGVTRDQRGNMGVSSGLELLTLPHGHHLRLELLERHQTLALAGALAVLGCSGPLEERAAALRGLVELALALRPGAAGDLPGLAAVMGALLMPQVSRLEHTWRQLRRSHTEAALAFEQELKPLMRALDEGAGPCDPGEVALPHVAPMVRLLEGEEVAGPLDESCERLLRTLHGARHMVRDAPKFRKVAAQRLRGFRPNPELREALTTGFVRRLLWGSRGAGAPRAERFEKFQRVLGVLSQRLEPDR", "length": 576, "header": "sp|Q9BRG2-1|SH23A_HUMAN Isoform 1 of SH2 domain-containing protein 3A OS=Homo sapiens OX=9606 GN=SH2D3A PE=1 SV=1 CANONICAL=Q9BRG2-1" }, "isoforms": [ { "isoform_ac": "M0QZQ6-1", "url": "", "sequence": { "sequence": "MQVPQDGEDLAGQPWYHGLLSRQKAEALLQQNGDFLVRASGSRGGNPVISCRWRGSALHFEVFRVALRPRPGRPTALFQLEDEQFPSIPALVHSYMTGRRPLSQATGAVVSRPVTWQGPLRRSFSEDTLMDGPARIEPLRARKWSNSQPADLAHMGRSREDPAGMESAPGTPSPAYPPWPVPGAPSWEHRPSPAIGRLPGHRPPGSDQRSAGQHGSLIWPGAAHSSPWTPLEVGTAGE", "length": 238, "header": "tr|M0QZQ6-1|M0QZQ6_HUMAN Computationally mapped isoform of SH2 domain containing 3A OS=Homo sapiens OX=9606 GN=SH2D3A PE=1 SV=1 CANONICAL=Q9BRG2-1" }, "locus": { "chromosome": "19", "start_pos": 6763748, "end_pos": 6754616, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000597687.1", "url": "https://www.ensembl.org/id/ENST00000597687.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000470700.1", "url": "https://www.ensembl.org/id/ENSP00000470700.1" } ] } }, { "isoform_ac": "Q9BRG2-1", "url": "", "sequence": { "sequence": "MQVPQDGEDLAGQPWYHGLLSRQKAEALLQQNGDFLVRASGSRGGNPVISCRWRGSALHFEVFRVALRPRPGRPTALFQLEDEQFPSIPALVHSYMTGRRPLSQATGAVVSRPVTWQGPLRRSFSEDTLMDGPARIEPLRARKWSNSQPADLAHMGRSREDPAGMEASTMPISALPRTSSDPVLLKAPAPLGTVADSLRASDGQLQAKAPTKPPRTPSFELPDASERPPTYCELVPRVPSVQGTSPSQSCPEPEAPWWEAEEDEEEENRCFTRPQAEISFCPHDAPSCLLGPQNRPLEPQVLHTLRGLFLEHHPGSTALHLLLVDCQATGLLGVTRDQRGNMGVSSGLELLTLPHGHHLRLELLERHQTLALAGALAVLGCSGPLEERAAALRGLVELALALRPGAAGDLPGLAAVMGALLMPQVSRLEHTWRQLRRSHTEAALAFEQELKPLMRALDEGAGPCDPGEVALPHVAPMVRLLEGEEVAGPLDESCERLLRTLHGARHMVRDAPKFRKVAAQRLRGFRPNPELREALTTGFVRRLLWGSRGAGAPRAERFEKFQRVLGVLSQRLEPDR", "length": 576, "header": "sp|Q9BRG2-1|SH23A_HUMAN Isoform 1 of SH2 domain-containing protein 3A OS=Homo sapiens OX=9606 GN=SH2D3A PE=1 SV=1 CANONICAL=Q9BRG2-1" }, "locus": { "chromosome": "19", "start_pos": 6763748, "end_pos": 6752596, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000245908.11", "url": "https://www.ensembl.org/id/ENST00000245908.11" }, { "database": "Ensembl Peptide", "id": "ENSP00000245908.5", "url": "https://www.ensembl.org/id/ENSP00000245908.5" } ] } }, { "isoform_ac": "Q9BRG2-2", "url": "", "sequence": { "sequence": "MEKTLLANLGTTASCPARARKWSNSQPADLAHMGRSREDPAGMEASTMPISALPRTSSDPVLLKAPAPLGTVADSLRASDGQLQAKAPTKPPRTPSFELPDASERPPTYCELVPRVPSVQGTSPSQSCPEPEAPWWEAEEDEEEENRCFTRPQAEISFCPHDAPSCLLGPQNRPLEPQVLHTLRGLFLEHHPGSTALHLLLVDCQATGLLGVTRDQRGNMGVSSGLELLTLPHGHHLRLELLERHQTLALAGALAVLGCSGPLEERAAALRGLVELALALRPGAAGDLPGLAAVMGALLMPQVRGEQGLEEAGVRVTGKTGEEACSDLFSQVSRLEHTWRQLRRSHTEAALAFEQELKPLMRALDEGAGPCDPGEVALPHVAPMVRLLEGEEVAGPLDESCERLLRTLHGARHMVRDAPKFRKVAAQRLRGFRPNPELREALTTGFVRRLLWGSRGAGAPRAERFEKFQRVLGVLSQRLEPDR", "length": 483, "header": "sp|Q9BRG2-2|SH23A_HUMAN Isoform 2 of SH2 domain-containing protein 3A OS=Homo sapiens OX=9606 GN=SH2D3A PE=1 SV=1 CANONICAL=Q9BRG2-1" }, "locus": { "chromosome": "19", "start_pos": 6763732, "end_pos": 6752596, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000437152.7", "url": "https://www.ensembl.org/id/ENST00000437152.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000393303.2", "url": "https://www.ensembl.org/id/ENSP00000393303.2" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 123, "end_pos": 123, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9BRG2", "url": "https://www.uniprot.org/uniprot/Q9BRG2" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "iPTMnet", "id": "Q9BRG2", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9BRG2" }, { "database": "phospho.ELM", "id": "Q9BRG2", "url": "http://phospho.elm.eu.org/byAccession/Q9BRG2.html" } ], "site_lbl": "Ser123" }, { "start_pos": 125, "end_pos": 125, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9BRG2", "url": "https://www.uniprot.org/uniprot/Q9BRG2" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "PubMed", "id": "21406692", "url": "https://glygen.org/publication/PubMed/21406692" }, { "database": "iPTMnet", "id": "Q9BRG2", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9BRG2" }, { "database": "PubMed", "id": "18767875", "url": "https://glygen.org/publication/PubMed/18767875" }, { "database": "PubMed", "id": "19415658", "url": "https://glygen.org/publication/PubMed/19415658" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" }, { "database": "PubMed", "id": "19664994", "url": "https://glygen.org/publication/PubMed/19664994" }, { "database": "phospho.ELM", "id": "Q9BRG2", "url": "http://phospho.elm.eu.org/byAccession/Q9BRG2.html" } ], "site_lbl": "Ser125" }, { "start_pos": 145, "end_pos": 145, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q9BRG2", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9BRG2" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Ser145" }, { "start_pos": 147, "end_pos": 147, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9BRG2", "url": "https://www.uniprot.org/uniprot/Q9BRG2" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "PubMed", "id": "21406692", "url": "https://glygen.org/publication/PubMed/21406692" }, { "database": "iPTMnet", "id": "Q9BRG2", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9BRG2" } ], "site_lbl": "Ser147" }, { "start_pos": 16, "end_pos": 16, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q9BRG2", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9BRG2" }, { "database": "PubMed", "id": "10187783", "url": "https://glygen.org/publication/PubMed/10187783" }, { "database": "phospho.ELM", "id": "Q9BRG2", "url": "http://phospho.elm.eu.org/byAccession/Q9BRG2.html" } ], "site_lbl": "Tyr16" }, { "start_pos": 180, "end_pos": 180, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9BRG2", "url": "https://www.uniprot.org/uniprot/Q9BRG2" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "PubMed", "id": "21406692", "url": "https://glygen.org/publication/PubMed/21406692" }, { "database": "iPTMnet", "id": "Q9BRG2", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9BRG2" }, { "database": "PubMed", "id": "19413330", "url": "https://glygen.org/publication/PubMed/19413330" }, { "database": "PubMed", "id": "19664994", "url": "https://glygen.org/publication/PubMed/19664994" }, { "database": "phospho.ELM", "id": "Q9BRG2", "url": "http://phospho.elm.eu.org/byAccession/Q9BRG2.html" } ], "site_lbl": "Ser180" }, { "start_pos": 201, "end_pos": 201, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q9BRG2", "url": "https://www.uniprot.org/uniprot/Q9BRG2" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "Q9BRG2", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9BRG2" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "phospho.ELM", "id": "Q9BRG2", "url": "http://phospho.elm.eu.org/byAccession/Q9BRG2.html" } ], "site_lbl": "Ser201" }, { "start_pos": 231, "end_pos": 231, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q9BRG2", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9BRG2" }, { "database": "PubMed", "id": "10187783", "url": "https://glygen.org/publication/PubMed/10187783" }, { "database": "phospho.ELM", "id": "Q9BRG2", "url": "http://phospho.elm.eu.org/byAccession/Q9BRG2.html" } ], "site_lbl": "Tyr231" }, { "start_pos": 95, "end_pos": 95, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q9BRG2", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9BRG2" }, { "database": "PubMed", "id": "10187783", "url": "https://glygen.org/publication/PubMed/10187783" }, { "database": "phospho.ELM", "id": "Q9BRG2", "url": "http://phospho.elm.eu.org/byAccession/Q9BRG2.html" } ], "site_lbl": "Tyr95" } ], "glycation": [], "keywords": [], "publication": [ { "title": "NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway.", "journal": "J. Biol. Chem.", "date": "1999", "authors": "Lu Y, Brush J, Stewart TA", "evidence": [ { "database": "UniProtKB", "id": "Q9BRG2", "url": "https://www.uniprot.org/uniprot/Q9BRG2" }, { "database": "iPTMnet", "id": "Q9BRG2-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9BRG2-1" } ], "reference": [ { "type": "PubMed", "id": "10187783", "url": "https://glygen.org/publication/PubMed/10187783" } ] }, { "title": "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.", "journal": "Genome Res.", "date": "2003", "authors": "Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A", "evidence": [ { "database": "UniProtKB", "id": "Q9BRG2", "url": "https://www.uniprot.org/uniprot/Q9BRG2" } ], "reference": [ { "type": "PubMed", "id": "12975309", "url": "https://glygen.org/publication/PubMed/12975309" } ] }, { "title": "The consensus coding sequences of human breast and colorectal cancers.", "journal": "Science", "date": "2006", "authors": "Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE", "evidence": [ { "database": "UniProtKB", "id": "Q9BRG2", "url": "https://www.uniprot.org/uniprot/Q9BRG2" } ], "reference": [ { "type": "PubMed", "id": "16959974", "url": "https://glygen.org/publication/PubMed/16959974" } ] }, { "title": "Splice variants and expression patterns of SHEP1, BCAR3 and NSP1, a gene family involved in integrin and receptor tyrosine kinase signaling.", "journal": "Gene", "date": "2007", "authors": "Vervoort VS, Roselli S, Oshima RG, Pasquale EB", "evidence": [ { "database": "RefSeq", "id": "NP_005481", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005481" } ], "reference": [ { "type": "PubMed", "id": "17270363", "url": "https://glygen.org/publication/PubMed/17270363" } ] }, { "title": "AND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology.", "journal": "Journal of cellular physiology", "date": "2007", "authors": "Near RI, Zhang Y, Makkinje A, Vanden Borre P, Lerner A", "evidence": [ { "database": "RefSeq", "id": "NP_005481", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005481" } ], "reference": [ { "type": "PubMed", "id": "17427198", "url": "https://glygen.org/publication/PubMed/17427198" } ] }, { "title": "A quantitative atlas of mitotic phosphorylation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2008", "authors": "Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "Q9BRG2", "url": "https://www.uniprot.org/uniprot/Q9BRG2" }, { "database": "iPTMnet", "id": "Q9BRG2-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9BRG2-1" } ], "reference": [ { "type": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ] }, { "title": "Successive and selective release of phosphorylated peptides captured by hydroxy acid-modified metal oxide chromatography.", "journal": "Journal of proteome research", "date": "2008", "authors": "Kyono Y, Sugiyama N, Imami K, Tomita M, Ishihama Y", "evidence": [ { "database": "iPTMnet", "id": "Q9BRG2-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9BRG2-1" } ], "reference": [ { "type": "PubMed", "id": "18767875", "url": "https://glygen.org/publication/PubMed/18767875" } ] }, { "title": "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.", "journal": "Analytical chemistry", "date": "2009", "authors": "Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S", "evidence": [ { "database": "iPTMnet", "id": "Q9BRG2-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9BRG2-1" } ], "reference": [ { "type": "PubMed", "id": "19413330", "url": "https://glygen.org/publication/PubMed/19413330" } ] }, { "title": "Phosphoproteomic analysis of distinct tumor cell lines in response to nocodazole treatment.", "journal": "Proteomics", "date": "2009", "authors": "Nagano K, Shinkawa T, Mutoh H, Kondoh O, Morimoto S, Inomata N, Ashihara M, Ishii N, Aoki Y, Haramura M", "evidence": [ { "database": "iPTMnet", "id": "Q9BRG2-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9BRG2-1" } ], "reference": [ { "type": "PubMed", "id": "19415658", "url": "https://glygen.org/publication/PubMed/19415658" } ] }, { "title": "Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics.", "journal": "Molecular & cellular proteomics : MCP", "date": "2009", "authors": "Pan C, Olsen JV, Daub H, Mann M", "evidence": [ { "database": "iPTMnet", "id": "Q9BRG2-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9BRG2-1" } ], "reference": [ { "type": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" } ] }, { "title": "Phosphoproteomic analysis of human embryonic stem cells.", "journal": "Cell stem cell", "date": "2009", "authors": "Brill LM, Xiong W, Lee KB, Ficarro SB, Crain A, Xu Y, Terskikh A, Snyder EY, Ding S", "evidence": [ { "database": "iPTMnet", "id": "Q9BRG2-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9BRG2-1" } ], "reference": [ { "type": "PubMed", "id": "19664994", "url": "https://glygen.org/publication/PubMed/19664994" } ] }, { "title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.", "journal": "Science signaling", "date": "2010", "authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M", "evidence": [ { "database": "UniProtKB", "id": "Q9BRG2", "url": "https://www.uniprot.org/uniprot/Q9BRG2" }, { "database": "iPTMnet", "id": "Q9BRG2-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9BRG2-1" } ], "reference": [ { "type": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ] }, { "title": "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.", "journal": "Science signaling", "date": "2011", "authors": "Rigbolt KT, Prokhorova TA, Akimov V, Henningsen J, Johansen PT, Kratchmarova I, Kassem M, Mann M, Olsen JV, Blagoev B", "evidence": [ { "database": "UniProtKB", "id": "Q9BRG2", "url": "https://www.uniprot.org/uniprot/Q9BRG2" }, { "database": "iPTMnet", "id": "Q9BRG2", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9BRG2" } ], "reference": [ { "type": "PubMed", "id": "21406692", "url": "https://glygen.org/publication/PubMed/21406692" } ] }, { "title": "Toward a comprehensive characterization of a human cancer cell phosphoproteome.", "journal": "Journal of proteome research", "date": "2013", "authors": "Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S", "evidence": [ { "database": "UniProtKB", "id": "Q9BRG2", "url": "https://www.uniprot.org/uniprot/Q9BRG2" }, { "database": "iPTMnet", "id": "Q9BRG2", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9BRG2" } ], "reference": [ { "type": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" } ] }, { "title": "Nsp1 proteins of human coronaviruses HCoV-OC43 and SARS-CoV2 inhibit stress granule formation.", "journal": "PLoS pathogens", "date": "2022-12", "authors": "Dolliver Stacia M, Kleer Mariel, Bui-Marinos Maxwell P, Ying Shan, Corcoran Jennifer A, Khaperskyy Denys A", "evidence": [ { "database": "RefSeq", "id": "NP_005481", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005481" } ], "reference": [ { "type": "PubMed", "id": "36534661", "url": "https://glygen.org/publication/PubMed/36534661" } ] } ], "pathway": [ { "id": "hsa:10045", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:10045", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "phosphotyrosine residue binding", "id": "GO:0001784", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001784", "evidence": [ { "database": 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