{ "uniprot_canonical_ac": "Q99P47-1", "uniprot_ac": "Q99P47", "uniprot_id": "CNTP4_MOUSE", "mass": { "chemical_mass": 144730.0, "monoisotopic_mass": 144730.0 }, "refseq": { "ac": "NP_569724", "name": "contactin-associated protein-like 4 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_569724" }, "gene_names": [ { "name": "Cntnap4", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q99P47", "id": "Q99P47" }, { "name": "Caspr4; E130114F09Rik", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_569724", "id": "NP_569724" }, { "name": "Caspr4", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q99P47", "id": "Q99P47" }, { "name": "Cntnap4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_569724", "id": "NP_569724" } ], "protein_names": [ { "name": "Contactin-associated protein-like 4", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q99P47" }, { "name": "Cell recognition molecule Caspr4", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q99P47" }, { "name": "cell recognition molecule Caspr4; contactin associated protein 4; cell recognition protein CASPR4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_569724", "id": "NP_569724" }, { "name": "contactin-associated protein-like 4 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_569724", "id": "NP_569724" } ], "function": [ { "annotation": "A novel biological functional axis for Nell-1 and Cntnap4 in osteogenesis and, potentially, in neural development and function, is reported.", "evidence": [ { "database": "RefSeq", "id": "NP_569724", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_569724" }, { "database": "PubMed", "id": "29905970", "url": "https://glygen.org/publication/PubMed/29905970" } ] }, { "annotation": "CNTNAP4 deficiency in dopaminergic neurons initiates parkinsonian phenotypes. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_569724", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_569724" }, { "database": "PubMed", "id": "32194851", "url": "https://glygen.org/publication/PubMed/32194851" } ] }, { "annotation": "Cntnap4 partial deficiency exacerbates alpha-synuclein pathology through astrocyte-microglia C3-C3aR pathway. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_569724", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_569724" }, { "database": "PubMed", "id": "37087484", "url": "https://glygen.org/publication/PubMed/37087484" } ] }, { "annotation": "Down-regulation or overexpression of CNTNAP4 in the hippocampus influenced the expression of gamma-aminobutyric acid A receptor beta2/3 membrane protein, without affecting total GABAARbeta2/3 protein concentration in epileptic mice", "evidence": [ { "database": "RefSeq", "id": "NP_569724", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_569724" }, { "database": "PubMed", "id": "28968899", "url": "https://glygen.org/publication/PubMed/28968899" } ] }, { "annotation": "Lactobacillus reuteri normalizes altered fear memory in male Cntnap4 knockout mice.", "evidence": [ { "database": "RefSeq", "id": "NP_569724", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_569724" }, { "database": "PubMed", "id": "36395738", "url": "https://glygen.org/publication/PubMed/36395738" } ] }, { "annotation": "Presynaptic protein involved in both dopaminergic synaptic transmission and GABAergic system, thereby participating in the structural maturation of inhibitory interneuron synapses. Involved in the dopaminergic synaptic transmission by attenuating dopamine release through a presynaptic mechanism. Also participates in the GABAergic system.", "evidence": [ { "database": "UniProtKB", "id": "Q99P47", "url": "https://www.uniprot.org/uniprot/Q99P47#function" }, { "database": "PubMed", "id": "24870235", "url": "https://glygen.org/publication/PubMed/24870235" } ] } ], "disease": [ { "disease_id": "DOID:0060041", "recommended_name": { "id": "DOID:0060041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060041", "name": "autism spectrum disorder", "description": "A pervasive developmental disorder that is a spectrum of psychological conditions. The disease has_symptom widespread abnormalities of social interactions and communication, has_symptom severely restricted interests and has_symptom highly repetitive behavior." }, "synonyms": [], "evidence": [ { "id": "0060041", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0060041" } ] }, { "disease_id": "DOID:0060308", "recommended_name": { "id": "DOID:0060308", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060308", "name": "autosomal recessive intellectual developmental disorder", "description": "A intellectual disability characterized by an autosomal recessive inheritance pattern." }, "synonyms": [ { "id": "DOID:0060308", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060308", "name": "autosomal recessive non-syndromic mental retardation", "description": "" }, { "id": "DOID:0060308", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060308", "name": "autosomal recessive mental retardation", "description": "" }, { "id": "MONDO:0009580", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009580", "name": "intellectual disability, autosomal recessive 1", "description": "Any autosomal recessive non-syndromic intellectual disability in which the cause of the disease is a mutation in the PRSS12 gene." }, { "id": "MONDO:0009580", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009580", "name": "PRSS12 autosomal recessive non-syndromic intellectual disability", "description": "" }, { "id": "MONDO:0009580", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009580", "name": "autosomal recessive non-syndromic intellectual disability caused by mutation in PRSS12", "description": "" }, { "id": "MONDO:0009580", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009580", "name": "intellectual disability, autosomal recessive 1", "description": "" }, { "id": "MONDO:0009580", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009580", "name": "intellectual disability, autosomal recessive type 1", "description": "" }, { "id": "MONDO:0009580", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009580", "name": "mental retardation, autosomal recessive type 1", "description": "" }, { "id": "MONDO:0009580", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009580", "name": "MRT1", "description": "" }, { "id": "MONDO:0009580", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0009580", "name": "mental retardation, autosomal recessive 1", "description": "" }, { "id": "MIM:249500", "resource": "MIM", "url": "https://www.omim.org/entry/249500", "name": "Intellectual developmental disorder, autosomal recessive 1", "description": "Intellectual developmental disorder, autosomal recessive 1" } ], "evidence": [ { "id": "0060308", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0060308" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q99P47", "url": "https://www.uniprot.org/uniprot/Q99P47" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Cntnap4", "url": "https://www.uniprot.org/uniprot/Q99P47", "locus": { "chromosome": "8", "start_pos": 113609349, "end_pos": 113296675, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000031772", "url": "https://www.ensembl.org/id/ENSMUSG00000031772" } ] } } ], "crossref": [ { "id": "ENSMUSG00000031772", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000031772", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00054", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00054", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00057", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00057", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00110", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00110", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "170571", "url": "https://www.ncbi.nlm.nih.gov/gene/170571", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "2232", "url": "https://glyconnect.expasy.org/browser/proteins/2232", "database": "GlyConnect", "categories": [ "Glycan", "Glycoproteomics" ] }, { "id": "GPDB0002121", "url": "https://acgg.asia/db/gpdb/symbol/GPDB0002121", "database": "GlycoProtDB", "categories": [ "Glycoproteomics" ] }, { "id": "GPDB0007264", "url": "https://acgg.asia/db/gpdb/symbol/GPDB0007264", "database": "GlycoProtDB", "categories": [ "Glycoproteomics" ] }, { "id": "IPR000421", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000421", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001791", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001791", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002181", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002181", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008979", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008979", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036056", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036056", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:170571", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:170571", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "2183572", "url": "http://www.informatics.jax.org/marker/MGI:2183572", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "Q99P47", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q99P47", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "LSTQNWS", "url": "https://omabrowser.org/oma/group/LSTQNWS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "4255614at2759", "url": "http://www.orthodb.org/?query=4255614at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR15036", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15036", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR15036:SF40", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15036:SF40", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00754", "url": "http://pfam.xfam.org/family/PF00754", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF02210", "url": "http://pfam.xfam.org/family/PF02210", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q99P47", "url": "http://purl.obolibrary.org/obo/PR_Q99P47", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_569724", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_569724", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "D3YWB9", "url": "https://www.uniprot.org/uniprot/D3YWB9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D3YWB9-1", "url": "https://www.uniprot.org/uniprot/D3YWB9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q99P47", "url": "https://www.uniprot.org/uniprot/Q99P47", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q99P47-1", "url": "https://www.uniprot.org/uniprot/Q99P47-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNMGSVAGAVLKMLLLLSTQNWNRVEAGNSYDCDEPLVSALPQASFSSSSELSSSHGPGFARLNRRDGAGGWSPLVSNKYQWLQIDLGERMEVTSVATQGGYGSSNWVTSYLLMFSDSGRNWKQYRQEDSIWGFSGNANADSVVYYRLQPSIKARFLRFIPLEWNPKGRIGMRIEVFGCAYRSVVIDLDGKSSLLYRFDQNSLSPIRDIISLKFKTMESDGILLHRAGPAGDHITLELRRGKLFLLINSGDARLTSSSTLINLTLGSLLDDQHWHSVLIQRLGKQVNFTVDEHRRHFHAQGEFNYLDLDYEISFGGISAPAKSVSLPYKHFHGCLENLFYNGVDVIGLVKEHSPQIITMGNASFSCSQPQSMPLTFLSPRSYLVLPASTKEEAISASFQFRTWNKAGLLLFSELQLVSGSLLLLLSDGKLKLTLYQPGKSPSDITAGAGLGDGQWHSVSLSAKRNHLSVVVDGHISPASPWLGPEQVNSGGVFYFGGCPDKGFGSKCKSPLGGFQGCMRLISINNKMVDLIAVQQGALGNFSDLQIDSCGISDRCLPNSCEHGGECSQSWSTFHCNCTNTGYTGATCHSSVYEQSCEAYKHQGNASGFYYIDSDGSGPLQPFLLYCNMTETAWTVMQHNGSDLMRVRNTHSENAHTGVFEYTASMEQLQAAINRAEHCQQELVYYCKKSRLVNQQDGSPRSWWVGRTNETQTYWGGSLPVHQKCTCGLEGNCIDAQYHCNCDADLNEWTNDTGFLSYKEHLPVTKIVITDTGRPHSEAAYKLGPLLCRGDRPFWNAASFNTEASYLHFPTFHGELSADVSFFFKTTALSGVFLENLGITDFIRIELRSPTTVTFSFDVGNGPFELSVHSPTHFNDNQWHHVRVERNMKEASLRVDELPPKIQAAPTDGHVLLQLNSQLFVGGTATRQRGFLGCIRSLQLNGMALDLEERATVTPGVQPGCRGHCGSYGKLCRHGGKCREKPSGFFCDCSSSAYAGPFCSKEISAYFGSGSSVIYNFQENYSLSKNSSFHAASFHGDMKLSREMIKFSFRTTRAPSLLLHMSSFYKEYLSIIIAKNGSLQIRYKLNKYHEPDVISFDLKSMADGQLHHIKINREEGMVFVEIDENTRRQTYLSSGTEFSAVKSLVLGRMLEYSDVDQETALAAAHGFTGCLSAVQFSHIAPLKAALQPGPPAPVTVTGHVTESSCVAPSGTDATSRERTHSFADHSGTMDDREPLTHAIKSDSAVIGGLIAVVIFILLCVSAIAVRIYQQKRLYKRNEAKRSENVDSAEAVLKSELHIQNAVGENQKEYFF", "length": 1310, "header": "sp|Q99P47-1|CNTP4_MOUSE Isoform 1 of Contactin-associated protein-like 4 OS=Mus musculus OX=10090 GN=Cntnap4 PE=1 SV=2 CANONICAL=Q99P47-1" }, "isoforms": [ { "isoform_ac": "D3YWB9-1", "url": "", "sequence": { "sequence": "MNMGSVAGAVLKMLLLLSTQNWNRVEAGNSYDCDEPLVSALPQASFSSSSELSSSHGPGFARLNRRDGAGGWSPLVSNKYQWLQIDLGERMEVTSVATQGGYGSSNWVTSYLLMFSDSGRNWKQYRQEDSIWGFSGNANADSVVYYRLQPSIKARFLRFIPLEWNPKGRIGMRIEVFGCAYRSVVIDLDGKSSLLYRFDQNSLSPIRDIISLKFKTMESDGILLHRAGPAGDHITLELRRGKLFLLINSGDARLTSSSTLINLTLGSLLDDQHWHSVLIQRLGKQVNFTVDEHRRHFHAQGEFNYLDLDYEISFGGISAPAKSVSLPYKHFHGCLENLFYNGVDVIGLVKEHSPQIITMGNASFSCSQPQSMPLTFLSPRSYLVLPASTKEEAISASFQFRTWNKAGLLLFSELQLVSGSLLLLLSDGKLKLTLYQPGKSPSDITAGAGLGDGQWHSVSLSAKRNHLSVVVDGHISPASPWLGPEQVNSGGVFYFGGCPDKGFGSKCKSPLGGFQGCMRLISINNKMVDLIAVQQGALGNFSDLQIDSCGISDRCLPNSCEHGGECSQSWSTFHCNCTNTGYTGATCHSSVYEQSCEAYKHQGNASGFYYIDSDGSGPLQPFLLYCNMTETAWTVMQHNGSDLMRVRNTHSENAHTGVFEYTASMEQLQAAINRAEHCQQELVYYCKKSRLVNQQDGSPRSWWVGRTNETQTYWGGSLPVHQKCTCGLEGNCIDAQYHCNCDADLNEWTNDTGFLSYKEHLPVTKIVITDTGRPHSEAAYKLGPLLCRGDRPFWNAASFNTEASYLHFPTFHGELSADVSFFFKTTALSGVFLENLGITDFIRIELRSPTTVTFSFDVGNGPFELSVHSPTHFNDNQWHHVRVERNMKEASLRVDELPPKIQAAPTDGHVLLQLNSQLFVGGTATRQRGFLGCIRSLQLNGMALDLEERATVTPGVQPGCRGHCGSYGKLCRHGGKCREKPSGFFCDCSSSAYAGPFCSKEISAYFGSGSSVIYNFQENYSLSKNSSFHAASFHGDMKLSREMIKFSFRTTRAPSLLLHMSSFYKEYLSIIIAKNGDLQIRYKLNKYHEPDVISFDLKSMADGQLHHIKINREEGMVFVEIDENTRRQTYLSSGTEFSAVKSLVLGRMLEYSDVDQETALAAAHGFTGCLSAVQFSHIAPLKAALQPGPPAPVTVTGHVTESSCVAPSGTDATSRERTHSFADHSGTMDDREPLTHAIKSDSAVIGGLIAVVIFILLCVSAIAVRIYQQKRLYKRNEAKRSENVDSAEAVLKSELHIQNAVGENQKEYFF", "length": 1310, "header": "tr|D3YWB9-1|CNTP4_MOUSE Computationally mapped isoform of Contactin-associated protein-like 4 OS=Mus musculus OX=10090 GN=Cntnap4 PE=1 SV=1 CANONICAL=Q99P47-1" }, "locus": { "chromosome": "8", "start_pos": 113608511, "end_pos": 113296767, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000118171.8", "url": "https://www.ensembl.org/id/ENSMUST00000118171.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000112511.2", "url": "https://www.ensembl.org/id/ENSMUSP00000112511.2" } ] } }, { "isoform_ac": "Q99P47-1", "url": "", "sequence": { "sequence": "MNMGSVAGAVLKMLLLLSTQNWNRVEAGNSYDCDEPLVSALPQASFSSSSELSSSHGPGFARLNRRDGAGGWSPLVSNKYQWLQIDLGERMEVTSVATQGGYGSSNWVTSYLLMFSDSGRNWKQYRQEDSIWGFSGNANADSVVYYRLQPSIKARFLRFIPLEWNPKGRIGMRIEVFGCAYRSVVIDLDGKSSLLYRFDQNSLSPIRDIISLKFKTMESDGILLHRAGPAGDHITLELRRGKLFLLINSGDARLTSSSTLINLTLGSLLDDQHWHSVLIQRLGKQVNFTVDEHRRHFHAQGEFNYLDLDYEISFGGISAPAKSVSLPYKHFHGCLENLFYNGVDVIGLVKEHSPQIITMGNASFSCSQPQSMPLTFLSPRSYLVLPASTKEEAISASFQFRTWNKAGLLLFSELQLVSGSLLLLLSDGKLKLTLYQPGKSPSDITAGAGLGDGQWHSVSLSAKRNHLSVVVDGHISPASPWLGPEQVNSGGVFYFGGCPDKGFGSKCKSPLGGFQGCMRLISINNKMVDLIAVQQGALGNFSDLQIDSCGISDRCLPNSCEHGGECSQSWSTFHCNCTNTGYTGATCHSSVYEQSCEAYKHQGNASGFYYIDSDGSGPLQPFLLYCNMTETAWTVMQHNGSDLMRVRNTHSENAHTGVFEYTASMEQLQAAINRAEHCQQELVYYCKKSRLVNQQDGSPRSWWVGRTNETQTYWGGSLPVHQKCTCGLEGNCIDAQYHCNCDADLNEWTNDTGFLSYKEHLPVTKIVITDTGRPHSEAAYKLGPLLCRGDRPFWNAASFNTEASYLHFPTFHGELSADVSFFFKTTALSGVFLENLGITDFIRIELRSPTTVTFSFDVGNGPFELSVHSPTHFNDNQWHHVRVERNMKEASLRVDELPPKIQAAPTDGHVLLQLNSQLFVGGTATRQRGFLGCIRSLQLNGMALDLEERATVTPGVQPGCRGHCGSYGKLCRHGGKCREKPSGFFCDCSSSAYAGPFCSKEISAYFGSGSSVIYNFQENYSLSKNSSFHAASFHGDMKLSREMIKFSFRTTRAPSLLLHMSSFYKEYLSIIIAKNGSLQIRYKLNKYHEPDVISFDLKSMADGQLHHIKINREEGMVFVEIDENTRRQTYLSSGTEFSAVKSLVLGRMLEYSDVDQETALAAAHGFTGCLSAVQFSHIAPLKAALQPGPPAPVTVTGHVTESSCVAPSGTDATSRERTHSFADHSGTMDDREPLTHAIKSDSAVIGGLIAVVIFILLCVSAIAVRIYQQKRLYKRNEAKRSENVDSAEAVLKSELHIQNAVGENQKEYFF", "length": 1310, "header": "sp|Q99P47-1|CNTP4_MOUSE Isoform 1 of Contactin-associated protein-like 4 OS=Mus musculus OX=10090 GN=Cntnap4 PE=1 SV=2 CANONICAL=Q99P47-1" }, "locus": { "chromosome": "8", "start_pos": 113608511, "end_pos": 113296767, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000034225", "url": "https://www.ensembl.org/id/ENSMUST00000034225" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000034225", "url": "https://www.ensembl.org/id/ENSMUSP00000034225" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 1019, "start_aa": "Asn", "end_pos": 1019, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1019", "evidence": [ { "id": "Q99P47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99P47#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 1025, "start_aa": "Asn", "end_pos": 1025, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1025", "evidence": [ { "id": "Q99P47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99P47#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 1075, "start_aa": "Asn", "end_pos": 1075, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1075", "evidence": [ { "id": "Q99P47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99P47#ptm_processing" } ] }, { "glytoucan_ac": "G06110VR", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 262, "start_aa": "Asn", "end_pos": 262, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn262", "evidence": [ { "id": "2232", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2232" }, { "id": "30899004", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30899004" } ] }, { "glytoucan_ac": "G64527OM", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 262, "start_aa": "Asn", "end_pos": 262, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn262", "evidence": [ { "id": "2232", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2232" }, { "id": "30899004", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30899004" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 262, "start_aa": "Asn", "end_pos": 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"publication": [ { "title": "Cntnap4 differentially contributes to GABAergic and dopaminergic synaptic transmission.", "journal": "Nature", "date": "2014", "authors": "Karayannis T, Au E, Patel JC, Kruglikov I, Markx S, Delorme R, Heron D, Salomon D, Glessner J, Restituito S, Gordon A, Rodriguez-Murillo L, Roy NC, Gogos JA, Rudy B, Rice ME, Karayiorgou M, Hakonarson H, Keren B, Huguet G, Bourgeron T, Hoeffer C, Tsien RW, Peles E, Fishell G", "evidence": [ { "database": "UniProtKB", "id": "Q99P47", "url": "https://www.uniprot.org/uniprot/Q99P47" } ], "reference": [ { "type": "PubMed", "id": "24870235", "url": "https://glygen.org/publication/PubMed/24870235" } ] }, { "title": "CNTNAP4 Impacts Epilepsy Through GABAA Receptors Regulation: Evidence From Temporal Lobe Epilepsy Patients and Mouse Models.", "journal": "Cerebral cortex (New York, N.Y. : 1991)", "date": "2018", "authors": "Shangguan Y, Xu X, Ganbat B, Li Y, Wang W, Yang Y, Lu X, Du C, Tian X, Wang X", "evidence": [ { "database": "RefSeq", "id": "NP_569724", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_569724" } ], "reference": [ { "type": "PubMed", "id": "28968899", "url": "https://glygen.org/publication/PubMed/28968899" } ] }, { "title": "Neurexin Superfamily Cell Membrane Receptor Contactin-Associated Protein Like-4 (Cntnap4) Is Involved in Neural EGFL-Like 1 (Nell-1)-Responsive Osteogenesis.", "journal": "Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research", "date": "2018", "authors": "Li C, Zheng Z, Ha P, Chen X, Jiang W, Sun S, Chen F, Asatrian G, Berthiaume EA, Kim JK, Chen EC, Pang S, Zhang X, Ting K, Soo C", "evidence": [ { "database": "RefSeq", "id": "NP_569724", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_569724" } ], "reference": [ { "type": "PubMed", "id": "29905970", "url": "https://glygen.org/publication/PubMed/29905970" } ] }, { "title": "Capturing site-specific heterogeneity with large-scale N-glycoproteome analysis.", "journal": "Nature communications", "date": "2019", "authors": "Riley NM, Hebert AS, Westphall MS, Coon JJ", "evidence": [ { "database": "GlyConnect", "id": "2232", "url": "https://glyconnect.expasy.org/browser/proteins/2232" } ], "reference": [ { "type": "PubMed", "id": "30899004", "url": "https://glygen.org/publication/PubMed/30899004" } ] }, { "title": "CNTNAP4 deficiency in dopaminergic neurons initiates parkinsonian phenotypes.", "journal": "Theranostics", "date": "2020", "authors": "Zhang W, Zhou M, Lu W, Gong J, Gao F, Li Y, Xu X, Lin Y, Zhang X, Ding L, Zhang Z, Li G, Chen X, Sun X, Zhu X, Xu P, Zhang Y", "evidence": [ { "database": "RefSeq", "id": "NP_569724", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_569724" } ], "reference": [ { "type": "PubMed", "id": "32194851", "url": "https://glygen.org/publication/PubMed/32194851" } ] }, { "title": "O-GlcNAcylation regulates dopamine neuron function, survival and degeneration in Parkinson disease.", "journal": "Brain : a journal of neurology", "date": "2020", "authors": "Lee BE, Kim HY, Kim HJ, Jeong H, Kim BG, Lee HE, Lee J, Kim HB, Lee SE, Yang YR, Yi EC, Hanover JA, Myung K, Suh PG, Kwon T, Kim JI", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q99P47", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q99P47" } ], "reference": [ { "type": "PubMed", "id": "33300544", "url": "https://glygen.org/publication/PubMed/33300544" } ] }, { "title": "Lactobacillus reuteri normalizes altered fear memory in male Cntnap4 knockout mice.", "journal": "EBioMedicine", "date": "2022-12", "authors": "Zhang Wenlong, Huang Jie, Gao Feng, You Qianglong, Ding Liuyan, Gong Junwei, Zhang Mengran, Ma Runfang, Zheng Shaohui, Sun Xiangdong, Zhang Yunlong", "evidence": [ { "database": "RefSeq", "id": "NP_569724", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_569724" } ], "reference": [ { "type": "PubMed", "id": "36395738", "url": "https://glygen.org/publication/PubMed/36395738" } ] }, { "title": "Cntnap4 partial deficiency exacerbates \u03b1-synuclein pathology through astrocyte-microglia C3-C3aR pathway.", "journal": "Cell death & disease", "date": "2023-04-22", "authors": "Zhang Wenlong, Ding Liuyan, Chen Huaqing, Zhang Mengran, Ma Runfang, Zheng Shaohui, Gong Junwei, Zhang Zhiling, Xu Huaxi, Xu Pingyi, Zhang Yunlong", "evidence": [ { "database": "RefSeq", "id": "NP_569724", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_569724" } ], "reference": [ { "type": "PubMed", "id": "37087484", "url": "https://glygen.org/publication/PubMed/37087484" } ] } ], "pathway": [ { "id": "mmu:170571", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:170571", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1M3J7-1", "protein_name": "Contactin associated protein family member 4", "gene_name": "Cntnap4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": 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"length": 1310 }, "evidence": [ { "id": "45237124", "url": "http://www.informatics.jax.org/homology/45237124", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9C0A0-1", "protein_name": "Contactin-associated protein-like 4", "gene_name": "CNTNAP4", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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