{ "uniprot_canonical_ac": "Q99NH8-1", "uniprot_ac": "Q99NH8", "uniprot_id": "TREM2_MOUSE", "mass": { "chemical_mass": 24527.0, "monoisotopic_mass": 24527.0 }, "refseq": { "ac": "NP_001259007", "name": "triggering receptor expressed on myeloid cells 2 isoform 2 precursor", "summary": "The protein encoded by this gene is part of the immunoglobulin and lectin-like superfamily and functions as part of the innate immune system. This gene forms part of a cluster of genes on mouse chromosome 17 thought to be involved in innate immunity. This protein associates with the adaptor protein Dap-12 and recruits several factors, such as kinases and phospholipase C-gamma, to form a receptor signaling complex that activates myeloid cells, including dendritic cells and microglia. In humans homozygous loss-of-function mutations in this gene cause Nasu-Hakola disease and mutations in this gene may be risk factors to the development of Alzheimer's disease. In mouse mutations of this gene serve as a pathophysiological model for polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (Nasu-Hakola disease) and for inflammatory bowel disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259007" }, "gene_names": [ { "name": "Trem2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q99NH8", "id": "Q99NH8" }, { "name": "TREM-2; Trem2a; Trem2b; Trem2c", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259007", "id": "NP_001259007" }, { "name": "Trem2a", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q99NH8", "id": "Q99NH8" }, { "name": "Trem2b", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q99NH8", "id": "Q99NH8" }, { "name": "Trem2c", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q99NH8", "id": "Q99NH8" }, { "name": "Trem2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259007", "id": "NP_001259007" } ], "protein_names": [ { "name": "Triggering receptor expressed on myeloid cells 2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q99NH8" }, { "name": "TREM-2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q99NH8" }, { "name": "Triggering receptor expressed on monocytes 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q99NH8" }, { "name": "triggering receptor expressed on myeloid cells 2 isoform 2 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259007", "id": "NP_001259007" }, { "name": "triggering receptor expressed on myeloid cells 2b; triggering receptor expressed on myeloid cells 2c; triggering receptor expressed on myeloid cells 2a; triggering receptor expressed on monocytes 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259007", "id": "NP_001259007" } ], "function": [ { "annotation": "Alzheimer risk-increasing TREM2 variant causes aberrant cortical synapse density and promotes network hyperexcitability in mouse models.", "evidence": [ { "database": "RefSeq", "id": "NP_001259007", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259007" }, { "database": "PubMed", "id": "37591465", "url": "https://glygen.org/publication/PubMed/37591465" } ] }, { "annotation": "Forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding (PubMed:11241283). Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia (PubMed:27477018, PubMed:29518356). Binding to amyloid-beta 42 mediates microglial activation, proliferation, migration, apoptosis and expression of pro-inflammatory cytokines, such as IL6R and CCL3, and the anti-inflammatory cytokine ARG1 (PubMed:27477018, PubMed:29518356). Acts as a receptor for lipoprotein particles such as LDL, VLDL, and HDL and for apolipoproteins such as APOA1, APOA2, APOB, APOE, APOE2, APOE3, APOE4, and CLU and enhances their uptake in microglia (PubMed:27477018). Binds phospholipids (preferably anionic lipids) such as phosphatidylserine, phosphatidylethanolamine, phosphatidylglycerol and sphingomyelin (By similarity). Regulates microglial proliferation by acting as an upstream regulator of the Wnt/beta-catenin signaling cascade (PubMed:28077724). Required for microglial phagocytosis of apoptotic neurons (PubMed:24990881). Also required for microglial activation and phagocytosis of myelin debris after neuronal injury and of neuronal synapses during synapse elimination in the developing brain (PubMed:15728241, PubMed:28592261, PubMed:29752066, PubMed:25631124). Regulates microglial chemotaxis and process outgrowth, and also the microglial response to oxidative stress and lipopolysaccharide (PubMed:30232263, PubMed:29663649, PubMed:28483841, PubMed:29859094). It suppresses PI3K and NF-kappa-B signaling in response to lipopolysaccharide; thus promoting phagocytosis, suppressing pro-inflammatory cytokine and nitric oxide production, inhibiting apoptosis and increasing expression of IL10 and TGFB (PubMed:29663649). During oxidative stress, it promotes anti-apoptotic NF-kappa-B signaling and ERK signaling (PubMed:28592261). Plays a role in microglial MTOR activation and metabolism (PubMed:28802038). Regulates age-related changes in microglial numbers (PubMed:30548312, PubMed:29752066, PubMed:25631124). Triggers activation of the immune responses in macrophages and dendritic cells (By similarity). Mediates cytokine-induced formation of multinucleated giant cells which are formed by the fusion of macrophages (PubMed:18957693). In dendritic cells, it mediates up-regulation of chemokine receptor CCR7 and dendritic cell maturation and survival (By similarity). Involved in the positive regulation of osteoclast differentiation (PubMed:16418779).", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8#function" }, { "database": "UniProtKB", "id": "Q9NZC2", "url": "https://www.uniprot.org/uniprot/Q9NZC2#function" }, { "database": "PubMed", "id": "24990881", "url": "https://glygen.org/publication/PubMed/24990881" }, { "database": "PubMed", "id": "11241283", "url": "https://glygen.org/publication/PubMed/11241283" }, { "database": "PubMed", "id": "29518356", "url": "https://glygen.org/publication/PubMed/29518356" }, { "database": "PubMed", "id": "29859094", "url": "https://glygen.org/publication/PubMed/29859094" }, { "database": "PubMed", "id": "29663649", "url": "https://glygen.org/publication/PubMed/29663649" }, { "database": "PubMed", "id": "28483841", "url": "https://glygen.org/publication/PubMed/28483841" }, { "database": "PubMed", "id": "29752066", "url": "https://glygen.org/publication/PubMed/29752066" }, { "database": "PubMed", "id": "30232263", "url": "https://glygen.org/publication/PubMed/30232263" }, { "database": "PubMed", "id": "25631124", "url": "https://glygen.org/publication/PubMed/25631124" }, { "database": "PubMed", "id": "18957693", "url": "https://glygen.org/publication/PubMed/18957693" }, { "database": "PubMed", "id": "27477018", "url": "https://glygen.org/publication/PubMed/27477018" }, { "database": "PubMed", "id": "28592261", "url": "https://glygen.org/publication/PubMed/28592261" }, { "database": "PubMed", "id": "15728241", "url": "https://glygen.org/publication/PubMed/15728241" }, { "database": "PubMed", "id": "30548312", "url": "https://glygen.org/publication/PubMed/30548312" }, { "database": "PubMed", "id": "28802038", "url": "https://glygen.org/publication/PubMed/28802038" }, { "database": "PubMed", "id": "16418779", "url": "https://glygen.org/publication/PubMed/16418779" }, { "database": "PubMed", "id": "28077724", "url": "https://glygen.org/publication/PubMed/28077724" } ] }, { "annotation": "TREM-2a and TREM-2b binding to both Gram-positive and Gram-negative bacteria is disrupted by anionic bacterial products or other anionic carbohydrates and suggests that TREM-2 recognizes pathogens via charged carbohydrates expressed on pathogen surface.", "evidence": [ { "database": "RefSeq", "id": "NP_001259007", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259007" }, { "database": "PubMed", "id": "12847223", "url": "https://glygen.org/publication/PubMed/12847223" } ] }, { "annotation": "TREM2 promotes glioma progression and angiogenesis mediated by microglia/brain macrophages.", "evidence": [ { "database": "RefSeq", "id": "NP_001259007", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259007" }, { "database": "PubMed", "id": "37641212", "url": "https://glygen.org/publication/PubMed/37641212" } ] }, { "annotation": "TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration.", "evidence": [ { "database": "RefSeq", "id": "NP_001259007", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259007" }, { "database": "PubMed", "id": "37442133", "url": "https://glygen.org/publication/PubMed/37442133" } ] }, { "annotation": "The protein encoded by this gene is part of the immunoglobulin and lectin-like superfamily and functions as part of the innate immune system. This gene forms part of a cluster of genes on mouse chromosome 17 thought to be involved in innate immunity. This protein associates with the adaptor protein Dap-12 and recruits several factors, such as kinases and phospholipase C-gamma, to form a receptor signaling complex that activates myeloid cells, including dendritic cells and microglia. In humans homozygous loss-of-function mutations in this gene cause Nasu-Hakola disease and mutations in this gene may be risk factors to the development of Alzheimer's disease. In mouse mutations of this gene serve as a pathophysiological model for polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (Nasu-Hakola disease) and for inflammatory bowel disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013].", "evidence": [ { "database": "RefSeq", "id": "NP_001259007", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259007" } ] } ], "disease": [ { "disease_id": "DOID:4166", "recommended_name": { "id": "DOID:4166", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4166", "name": "syphilis", "description": "A primary bacterial infectious disease that is a sexually transmitted systemic disease, has_material_basis_in Treponema pallidum subsp pallidum, which is transmitted_by sexual contact, transmitted_by blood product transfusion, transmitted_by congenital method from mother to fetus or transmitted_by contact with infectious lesions. If left untreated, produces chancres, rashes, and systemic lesions in a clinical course with three stages continued over many years." }, "synonyms": [ { "id": "DOID:4166", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4166", "name": "syphilitic chancre", "description": "" } ], "evidence": [ { "id": "4166", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:4166" } ] }, { "disease_id": "DOID:9255", "recommended_name": { "id": "DOID:9255", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9255", "name": "frontotemporal dementia", "description": "A dementia characterized by progressive neuronal loss predominantly involving the frontal and/or temporal lobes of the brain resulting in a gradual and progressive decline in behavior or language." }, "synonyms": [ { "id": "DOID:9255", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9255", "name": "Wilhemsen-Lynch disease", "description": "" }, { "id": "DOID:9255", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9255", "name": "frontotemporal lobar degeneration", "description": "" }, { "id": "DOID:9255", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9255", "name": "multiple system tauopathy with presenile dementia", "description": "" }, { "id": "DOID:9255", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9255", "name": "pallidopontonigral degeneration", "description": "" }, { "id": "MONDO:0010857", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010857", "name": "semantic dementia", "description": "Semantic dementia (SD) is a form of frontotemporal dementia (FTD), characterized by the progressive, amodal and profound loss of semantic knowledge (combination of visual associative agnosia, anomia, surface dyslexia or dysgraphia and disrupted comprehension of word meaning) and behavioral abnormalities, attributable to the degeneration of the anterior temporal lobes." }, { "id": "MONDO:0010857", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010857", "name": "dementia, frontotemporal", "description": "" }, { "id": "MONDO:0010857", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010857", "name": "dementia, frontotemporal, with or without parkinsonism", "description": "" }, { "id": "MONDO:0010857", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010857", "name": "semantic primary progressive aphasia", "description": "" }, { "id": "MONDO:0010857", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010857", "name": "semantic variant PPA", "description": "" }, { "id": "MONDO:0010857", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010857", "name": "FTD", "description": "" }, { "id": "MONDO:0010857", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010857", "name": "Ftdp17", "description": "" }, { "id": "MONDO:0010857", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010857", "name": "Ftld with Tau inclusions", "description": "" }, { "id": "MONDO:0010857", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010857", "name": "Pallidopontonigral Degeneration", "description": "" }, { "id": "MONDO:0010857", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010857", "name": "Pick Complex", "description": "" }, { "id": "MONDO:0010857", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010857", "name": "Wilhelmsen-Lynch disease", "description": "" }, { "id": "MONDO:0010857", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010857", "name": "dementia, frontotemporal, with Parkinsonism", "description": "" }, { "id": "MONDO:0010857", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010857", "name": "disinhibition-dementia-Parkinsonism-amyotrophy Complex", "description": "" }, { "id": "MONDO:0010857", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010857", "name": "frontotemporal dementia", "description": "" }, { "id": "MONDO:0010857", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010857", "name": "frontotemporal dementia with Parkinsonism", "description": "" }, { "id": "MONDO:0010857", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010857", "name": "frontotemporal lobar Degeneration with Tau inclusions", "description": "" }, { "id": "MONDO:0010857", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010857", "name": "frontotemporal lobe dementia", "description": "" }, { "id": "MONDO:0010857", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010857", "name": "multiple system tauopathy with presenile dementia", "description": "" }, { "id": "MIM:600274", "resource": "MIM", "url": "https://www.omim.org/entry/600274", "name": "Frontotemporal dementia", "description": "Frontotemporal dementia" } ], "evidence": [ { "id": "9255", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:9255" } ] } ], "snv": [ { "evidence": [ { "id": "rs3389428565", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs3389428565" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 20, "end_pos": 20, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NTT->STT).", "chr_id": "17", "chr_pos": "48655503", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N20", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs3389428565", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs3389428565" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 20, "end_pos": 20, "sequence_org": "N", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NTT->TTT).", "chr_id": "17", "chr_pos": "48655503", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N20", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs3407734028", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs3407734028" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 22, "end_pos": 22, "sequence_org": "T", "sequence_mut": "M", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NTT->NTM).", "chr_id": "17", "chr_pos": "48655509", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T22", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [ { "start_pos": 47, "end_pos": 47, "sequence_org": "R", "sequence_mut": "H", "comment": "Decreases myeloid cell immune response. Reduces expression levels.", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" }, { "database": "PubMed", "id": "29794134", "url": "https://glygen.org/publication/PubMed/29794134" }, { "database": "PubMed", "id": "29859094", "url": "https://glygen.org/publication/PubMed/29859094" } ] }, { "start_pos": 66, "end_pos": 66, "sequence_org": "T", "sequence_mut": "M", "comment": "Macrophages exhibit increased apoptosis, reduced proliferation, and reduced phagocytosis. Macrophages also exhibit increased inflammatory cytokine secretion. Microglia demonstrate reduced immune activity. Also decreases cerebral blood flow and reduces cerebral glucose metabolism.", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" }, { "database": "PubMed", "id": "28559417", "url": "https://glygen.org/publication/PubMed/28559417" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Trem2", "url": "https://www.uniprot.org/uniprot/Q99NH8", "locus": { "chromosome": "17", "start_pos": 48661175, "end_pos": 48653429, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000023992", "url": "https://www.ensembl.org/id/ENSMUSG00000023992" } ] } } ], "crossref": [ { "id": "ENSMUSG00000023992", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000023992", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "83433", "url": "https://www.ncbi.nlm.nih.gov/gene/83433", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q99NH8", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q99NH8*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013106", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:83433", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:83433", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1913150", "url": "http://www.informatics.jax.org/marker/MGI:1913150", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "KWREKSW", "url": "https://omabrowser.org/oma/group/KWREKSW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5000573at2759", "url": "http://www.orthodb.org/?query=5000573at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR16423", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16423", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR16423:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR16423:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF07686", "url": "http://pfam.xfam.org/family/PF07686", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q99NH8", "url": "http://purl.obolibrary.org/obo/PR_Q99NH8", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-198933", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-198933", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-2172127", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2172127", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-2424491", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2424491", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-416700", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-416700", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001259007", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259007", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q99NH8-1", "url": "https://www.uniprot.org/uniprot/Q99NH8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q99NH8-2", "url": "https://www.uniprot.org/uniprot/Q99NH8-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGPLHQFLLLLITALSQALNTTVLQGMAGQSLRVSCTYDALKHWGRRKAWCRQLGEEGPCQRVVSTHGVWLLAFLKKRNGSTVIADDTLAGTVTITLKNLQAGDAGLYQCQSLRGREAEVLQKVLVEVLEDPLDDQDAGDLWVPEESSSFEGAQVEHSTSRNQETSFPPTSILLLLACVLLSKFLAASILWAVARGRQKPGTPVVRGLDCGQDAGHQLQILTGPGGT", "length": 227, "header": "sp|Q99NH8-1|TREM2_MOUSE Isoform 1 of Triggering receptor expressed on myeloid cells 2 OS=Mus musculus OX=10090 GN=Trem2 PE=1 SV=1 CANONICAL=Q99NH8-1" }, "isoforms": [ { "isoform_ac": "Q99NH8-1", "url": "", "sequence": { "sequence": "MGPLHQFLLLLITALSQALNTTVLQGMAGQSLRVSCTYDALKHWGRRKAWCRQLGEEGPCQRVVSTHGVWLLAFLKKRNGSTVIADDTLAGTVTITLKNLQAGDAGLYQCQSLRGREAEVLQKVLVEVLEDPLDDQDAGDLWVPEESSSFEGAQVEHSTSRNQETSFPPTSILLLLACVLLSKFLAASILWAVARGRQKPGTPVVRGLDCGQDAGHQLQILTGPGGT", "length": 227, "header": "sp|Q99NH8-1|TREM2_MOUSE Isoform 1 of Triggering receptor expressed on myeloid cells 2 OS=Mus musculus OX=10090 GN=Trem2 PE=1 SV=1 CANONICAL=Q99NH8-1" }, "locus": { "chromosome": "17", "start_pos": 48659049, "end_pos": 48653584, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000024791", "url": "https://www.ensembl.org/id/ENSMUST00000024791" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000024791", "url": "https://www.ensembl.org/id/ENSMUSP00000024791" } ] } }, { "isoform_ac": "Q99NH8-2", "url": "", "sequence": { "sequence": "MGPLHQFLLLLITALSQALNTTVLQGMAGQSLRVSCTYDALKHWGRRKAWCRQLGEEGPCQRVVSTHGVWLLAFLKKRNGSTVIADDTLAGTVTITLKNLQAGDAGLYQCQSLRGREAEVLQKVLVEVLEDPLDDQDAGDLWVPEESSSFEGAQVEHSTSRQVSSCGSPLAYHLPPLSKESRDLLPTHLHSSPPGLRSPEQVSCSQHPLGCGQGQAEAGNTCGQRAGLWPRCWAPTSDPHWTRRYVREF", "length": 249, "header": "sp|Q99NH8-2|TREM2_MOUSE Isoform 2 of Triggering receptor expressed on myeloid cells 2 OS=Mus musculus OX=10090 GN=Trem2 PE=1 SV=1 CANONICAL=Q99NH8-1" }, "locus": { "chromosome": "17", "start_pos": 48659060, "end_pos": 48653584, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000113237", "url": "https://www.ensembl.org/id/ENSMUST00000113237" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000108863", "url": "https://www.ensembl.org/id/ENSMUSP00000108863" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 20, "start_aa": "Asn", "end_pos": 20, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn20", "evidence": [ { "id": "Q99NH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99NH8#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 79, "start_aa": "Asn", "end_pos": 79, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn79", "evidence": [ { "id": "Q99NH8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99NH8#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes.", "journal": "J. Immunol.", "date": "2000", "authors": "Bouchon A, Dietrich J, Colonna M", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "reference": [ { "type": "PubMed", "id": "10799849", "url": "https://glygen.org/publication/PubMed/10799849" } ] }, { "title": "Cloning and characterization of a novel mouse myeloid DAP12-associated receptor family.", "journal": "Eur. J. Immunol.", "date": "2001", "authors": "Daws MR, Lanier LL, Seaman WE, Ryan JC", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "reference": [ { "type": "PubMed", "id": "11241283", "url": "https://glygen.org/publication/PubMed/11241283" } ] }, { "title": "Heterogeneous expression of the triggering receptor expressed on myeloid cells-2 on adult murine microglia.", "journal": "J. Neurochem.", "date": "2002", "authors": "Danielson P.E., Sutcliffe J.G., Cooper J., Schmid C.D., Hasel K.W., Carson M.J., Sautkulis L.N., Hilbush B.S.", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "reference": [ { "type": "PubMed", "id": "12472885", "url": "https://glygen.org/publication/PubMed/12472885" } ] }, { "title": "Pattern recognition by TREM-2: binding of anionic ligands.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2003", "authors": "Daws MR, Sullam PM, Niemi EC, Chen TT, Tchao NK, Seaman WE", "evidence": [ { "database": "RefSeq", "id": "NP_001259007", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259007" } ], "reference": [ { "type": "PubMed", "id": "12847223", "url": "https://glygen.org/publication/PubMed/12847223" } ] }, { "title": "Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2.", "journal": "J. Exp. Med.", "date": "2005", "authors": "Takahashi K., Neumann H., Rochford C.D.", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "reference": [ { "type": "PubMed", "id": "15728241", "url": "https://glygen.org/publication/PubMed/15728241" } ] }, { "title": "TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function.", "journal": "J. Bone Miner. Res.", "date": "2006", "authors": "Humphrey MB, Daws MR, Spusta SC, Niemi EC, Torchia JA, Lanier LL, Seaman WE, Nakamura MC", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "reference": [ { "type": "PubMed", "id": "16418779", "url": "https://glygen.org/publication/PubMed/16418779" } ] }, { "title": "Essential role of DAP12 signaling in macrophage programming into a fusion-competent state.", "journal": "Sci. Signal.", "date": "2008", "authors": "Gordon S., Takai T., Vivier E., Tomasello E., Helming L., Kyriakides T.R., Martinez F.O.", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "reference": [ { "type": "PubMed", "id": "18957693", "url": "https://glygen.org/publication/PubMed/18957693" } ] }, { "title": "TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis.", "journal": "Sci. Transl. Med.", "date": "2014", "authors": "Kleinberger G, Yamanishi Y, Suarez-Calvet M, Czirr E, Lohmann E, Cuyvers E, Struyfs H, Pettkus N, Wenninger-Weinzierl A, Mazaheri F, Tahirovic S, Lleo A, Alcolea D, Fortea J, Willem M, Lammich S, Molinuevo JL, Sanchez-Valle R, Antonell A, Ramirez A, Heneka MT, Sleegers K, van der Zee J, Martin JJ, Engelborghs S, Demirtas-Tatlidede A, Zetterberg H, Van Broeckhoven C, Gurvit H, Wyss-Coray T, Hardy J, Colonna M, Haass C", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "reference": [ { "type": "PubMed", "id": "24990881", "url": "https://glygen.org/publication/PubMed/24990881" } ] }, { "title": "TREM2 regulates microglial cell activation in response to demyelination in vivo.", "journal": "Acta Neuropathol.", "date": "2015", "authors": "Bollman B., Schmidt R., Olivecrona G., Galimberti D., Cantoni C., Piccio L., Licastro D., Xie M., Otero K., Klein R.S., Cross A.H., Mikesell R., Yuede C.M.", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "reference": [ { "type": "PubMed", "id": "25631124", "url": "https://glygen.org/publication/PubMed/25631124" } ] }, { "title": "TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia.", "journal": "Neuron", "date": "2016", "authors": "Yeh FL, Wang Y, Tom I, Gonzalez LC, Sheng M", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "reference": [ { "type": "PubMed", "id": "27477018", "url": "https://glygen.org/publication/PubMed/27477018" } ] }, { "title": "TREM2 Promotes Microglial Survival by Activating Wnt/beta-Catenin Pathway.", "journal": "J. Neurosci.", "date": "2017", "authors": "Wang X., Xu H., Zheng H., Zhong L., Yang L., Bu G., Liu C.C., Fryer J.D., Zhang Y.W., Rong Z., Jia L., Chen X.F.", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "reference": [ { "type": "PubMed", "id": "28077724", "url": "https://glygen.org/publication/PubMed/28077724" } ] }, { "title": "TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury.", "journal": "EMBO Rep.", "date": "2017", "authors": "Capell A., Haass C., Wurst W., Brunner B., Tahirovic S., Krasemann S., Bultmann S., Truembach D., Kleinberger G., Mazaheri F., Butovsky O., Daria A., Kerschensteiner M., Madore C., Misgeld T., Snaidero N., Werner G.", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "reference": [ { "type": "PubMed", "id": "28483841", "url": "https://glygen.org/publication/PubMed/28483841" } ] }, { "title": "The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism.", "journal": "EMBO J.", "date": "2017", "authors": "Kleinberger G, Brendel M, Mracsko E, Wefers B, Groeneweg L, Xiang X, Focke C, Deussing M, Suarez-Calvet M, Mazaheri F, Parhizkar S, Pettkus N, Wurst W, Feederle R, Bartenstein P, Mueggler T, Arzberger T, Knuesel I, Rominger A, Haass C", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "reference": [ { "type": "PubMed", "id": "28559417", "url": "https://glygen.org/publication/PubMed/28559417" } ] }, { "title": "TREM2 protects against cerebral ischemia/reperfusion injury.", "journal": "Mol. Brain", "date": "2017", "authors": "Huang X., Jiang J., Li X., Wu R., Cheng J., Huang L., Tang Y., Xu P., Wu L.J.", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "reference": [ { "type": "PubMed", "id": "28592261", "url": "https://glygen.org/publication/PubMed/28592261" } ] }, { "title": "TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease.", "journal": "Cell", "date": "2017", "authors": "Ulland TK, Song WM, Huang SC, Ulrich JD, Sergushichev A, Beatty WL, Loboda AA, Zhou Y, Cairns NJ, Kambal A, Loginicheva E, Gilfillan S, Cella M, Virgin HW, Unanue ER, Wang Y, Artyomov MN, Holtzman DM, Colonna M", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "reference": [ { "type": "PubMed", "id": "28802038", "url": "https://glygen.org/publication/PubMed/28802038" } ] }, { "title": "TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant.", "journal": "EMBO Mol. Med.", "date": "2017", "authors": "Thornton P, Sevalle J, Deery MJ, Fraser G, Zhou Y, Stahl S, Franssen EH, Dodd RB, Qamar S, Gomez Perez-Nievas B, Nicol LS, Eketjall S, Revell J, Jones C, Billinton A, St George-Hyslop PH, Chessell I, Crowther DC", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "reference": [ { "type": "PubMed", "id": "28855301", "url": "https://glygen.org/publication/PubMed/28855301" } ] }, { "title": "TREM2 Is a Receptor for beta-Amyloid that Mediates Microglial Function.", "journal": "Neuron", "date": "2018", "authors": "Zhao Y, Wu X, Li X, Jiang LL, Gui X, Liu Y, Sun Y, Zhu B, Pina-Crespo JC, Zhang M, Zhang N, Chen X, Bu G, An Z, Huang TY, Xu H", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "reference": [ { "type": "PubMed", "id": "29518356", "url": "https://glygen.org/publication/PubMed/29518356" } ] }, { "title": "TREM2 inhibits inflammatory responses in mouse microglia by suppressing the PI3K/NF-kappaB signaling.", "journal": "Cell Biol. Int.", "date": "2019", "authors": "Li C., Lin C., Zhao B., An X., Gong Z.", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "reference": [ { "type": "PubMed", "id": "29663649", "url": "https://glygen.org/publication/PubMed/29663649" } ] }, { "title": "The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity.", "journal": "Immunity", "date": "2018", "authors": "Filipello F., Piccio L., Fahnestock M., Matteoli M., Otero K., Rajendran L., Menna E., Canzi A., Cignarella F., Corradini I., Erreni M., Genua M., Markicevic M., Michalski B., Morini R., Paolicelli R.C., Perrucci F., Starvaggi-Cucuzza C., Tamborini M., Vetrano S., Zerbi V.", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "reference": [ { "type": "PubMed", "id": "29752066", "url": "https://glygen.org/publication/PubMed/29752066" } ] }, { "title": "Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2.", "journal": "J. Biol. Chem.", "date": "2018", "authors": "Sudom A, Talreja S, Danao J, Bragg E, Kegel R, Min X, Richardson J, Zhang Z, Sharkov N, Marcora E, Thibault S, Bradley J, Wood S, Lim AC, Chen H, Wang S, Foltz IN, Sambashivan S, Wang Z", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "reference": [ { "type": "PubMed", "id": "29794134", "url": "https://glygen.org/publication/PubMed/29794134" } ] }, { "title": "The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease.", "journal": "Mol. Neurodegener.", "date": "2018", "authors": "Cheng-Hathaway PJ, Reed-Geaghan EG, Jay TR, Casali BT, Bemiller SM, Puntambekar SS, von Saucken VE, Williams RY, Karlo JC, Moutinho M, Xu G, Ransohoff RM, Lamb BT, Landreth GE", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "reference": [ { "type": "PubMed", "id": "29859094", "url": "https://glygen.org/publication/PubMed/29859094" } ] }, { "title": "Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2018", "authors": "Gao F., Li Y., Zhou Y., Gan L., Zhan L., Akassoglou K., Coppola G., Ludwig C., Davalos D., Le D., Clelland C., Cooper Y.A., Hauduc A., Kodama L., Sayed F.A., Telpoukhovskaia M.", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "reference": [ { "type": "PubMed", "id": "30232263", "url": "https://glygen.org/publication/PubMed/30232263" } ] }, { "title": "TREM2 triggers microglial density and age-related neuronal loss.", "journal": "Glia", "date": "2019", "authors": "Linnartz-Gerlach B, Bodea LG, Klaus C, Ginolhac A, Halder R, Sinkkonen L, Walter J, Colonna M, Neumann H", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "reference": [ { "type": "PubMed", "id": "30548312", "url": "https://glygen.org/publication/PubMed/30548312" } ] }, { "title": "TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration.", "journal": "Immunity", "date": "2023-08-08", "authors": "Zhong Li, Sheng Xuan, Wang Wanbing, Li Yanzhong, Zhuo Rengong, Wang Kai, Zhang Lianshuai, Hu Dan-Dan, Hong Yujuan, Chen Linting, Rao Hengjun, Li Tingting, Chen Muyang, Lin Zhihao, Zhang Yun-Wu, Wang Xin, Yan Xiao-Xin, Chen Xiaochun, Bu Guojun, Chen Xiao-Fen", "evidence": [ { "database": "RefSeq", "id": "NP_001259007", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259007" } ], "reference": [ { "type": "PubMed", "id": "37442133", "url": "https://glygen.org/publication/PubMed/37442133" } ] }, { "title": "Alzheimer risk-increasing TREM2 variant causes aberrant cortical synapse density and promotes network hyperexcitability in mouse models.", "journal": "Neurobiology of disease", "date": "2023-10-01", "authors": "Das Melanie, Mao Wenjie, Voskobiynyk Yuliya, Necula Deanna, Lew Irene, Petersen Cathrine, Zahn Allie, Yu Gui-Qiu, Yu Xinxing, Smith Nicholas, Sayed Faten A, Gan Li, Paz Jeanne T, Mucke Lennart", "evidence": [ { "database": "RefSeq", "id": "NP_001259007", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259007" } ], "reference": [ { "type": "PubMed", "id": "37591465", "url": "https://glygen.org/publication/PubMed/37591465" } ] }, { "title": "TREM2 promotes glioma progression and angiogenesis mediated by microglia/brain macrophages.", "journal": "Glia", "date": "2023-11", "authors": "Chen Xuezhen, Zhao Yue, Huang Yimin, Zhu Kaichuan, Zeng Fan, Zhao Junyi, Zhang Huaqiu, Zhu Xinzhou, Kettenmann Helmut, Xiang Xianyuan", "evidence": [ { "database": "RefSeq", "id": "NP_001259007", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259007" } ], "reference": [ { "type": "PubMed", "id": "37641212", "url": "https://glygen.org/publication/PubMed/37641212" } ] } ], "pathway": [ { "id": "mmu:83433", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:83433", "resource": "KEGG Pathway" }, { "id": "R-MMU-198933", "name": "Immunoregulatory 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"https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "social behavior", "id": "GO:0035176", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035176", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "positive regulation of amyloid-beta clearance", "id": "GO:1900223", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900223", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "positive regulation of engulfment of apoptotic cell", "id": "GO:1901076", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901076", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "defense response to bacterium", "id": "GO:0042742", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042742", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "response to axon injury", "id": "GO:0048678", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048678", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "negative regulation of cytokine production involved in inflammatory response", "id": "GO:1900016", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900016", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "regulation of intracellular signal transduction", "id": "GO:1902531", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902531", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "positive regulation of low-density lipoprotein particle clearance", "id": "GO:1905581", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905581", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "phagocytosis, recognition", "id": "GO:0006910", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006910", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "apoptotic cell clearance", "id": "GO:0043277", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043277", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "positive regulation of phagocytosis, engulfment", "id": "GO:0060100", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060100", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "regulation of gene expression", "id": "GO:0010468", "url": 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"name": "cellular response to lipoteichoic acid", "id": "GO:0071223", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071223", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "cellular response to oxidised low-density lipoprotein particle stimulus", "id": "GO:0140052", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140052", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "negative regulation of p38MAPK cascade", "id": "GO:1903753", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903753", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "microglial cell activation involved in immune response", "id": "GO:0002282", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002282", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "cellular response to peptidoglycan", "id": "GO:0071224", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071224", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "respiratory burst after phagocytosis", "id": "GO:0045728", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045728", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "negative regulation of macrophage colony-stimulating factor signaling pathway", "id": "GO:1902227", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902227", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "positive regulation of chemotaxis", "id": "GO:0050921", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050921", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "positive regulation of high-density lipoprotein particle clearance", "id": "GO:0010983", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010983", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "cellular response to lipid", "id": "GO:0071396", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071396", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "regulation of cytokine production involved in inflammatory response", "id": "GO:1900015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900015", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "positive regulation of osteoclast differentiation", "id": "GO:0045672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045672", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "dendritic cell differentiation", "id": "GO:0097028", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097028", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "negative regulation of toll-like receptor 4 signaling pathway", "id": "GO:0034144", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034144", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "regulation of innate immune response", "id": "GO:0045088", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045088", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "positive regulation of proteasomal protein catabolic process", "id": "GO:1901800", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901800", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "negative regulation of glial cell apoptotic process", "id": "GO:0034351", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034351", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "detection of lipopolysaccharide", "id": "GO:0032497", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032497", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "negative regulation of autophagic cell death", "id": "GO:1904093", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904093", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "microglial cell proliferation", "id": "GO:0061518", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061518", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "negative regulation of amyloid fibril formation", "id": "GO:1905907", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905907", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "amyloid-beta clearance", "id": "GO:0097242", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097242", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "dendritic spine maintenance", "id": "GO:0097062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097062", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "import into cell", "id": "GO:0098657", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098657", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "negative regulation of astrocyte activation", "id": "GO:0061889", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061889", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "negative regulation of NLRP3 inflammasome complex assembly", "id": "GO:1900226", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900226", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "positive regulation of mitochondrion organization", "id": "GO:0010822", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010822", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "detection of peptidoglycan", "id": "GO:0032499", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032499", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "detection of lipoteichoic acid", "id": "GO:0070392", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070392", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "positive regulation of C-C chemokine receptor CCR7 signaling pathway", "id": "GO:1903082", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903082", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "positive regulation of CD40 signaling pathway", "id": "GO:2000350", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000350", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "CXCL12-activated CXCR4 signaling pathway", "id": "GO:0038160", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038160", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "complement-mediated synapse pruning", "id": "GO:0150062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0150062", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "negative regulation of neuroinflammatory response", "id": "GO:0150079", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0150079", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "positive regulation of neuroinflammatory response", "id": "GO:0150078", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0150078", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "neuroinflammatory response", "id": "GO:0150076", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0150076", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "regulation of macrophage inflammatory protein 1 alpha production", "id": "GO:0071640", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071640", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "regulation of plasma membrane bounded cell projection organization", "id": "GO:0120035", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120035", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "positive regulation of CAMKK-AMPK signaling cascade", "id": "GO:1905291", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905291", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "amyloid-beta clearance by cellular catabolic process", "id": "GO:0150094", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0150094", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "positive regulation of synapse pruning", "id": "GO:1905808", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905808", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "regulation of toll-like receptor 6 signaling pathway", "id": "GO:0034151", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034151", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "positive regulation of complement activation, classical pathway", "id": "GO:0045960", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045960", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "regulation of hippocampal neuron apoptotic process", "id": "GO:0110089", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0110089", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "excitatory synapse pruning", "id": "GO:1905805", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905805", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 21, "go_terms": [ { "name": "kinase activator activity", "id": "GO:0019209", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019209", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "peptidoglycan binding", "id": "GO:0042834", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042834", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "transmembrane signaling receptor activity", "id": "GO:0004888", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004888", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "phospholipid binding", "id": "GO:0005543", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005543", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "apolipoprotein binding", "id": "GO:0034185", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034185", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "amyloid-beta binding", "id": "GO:0001540", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001540", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "protein-containing complex binding", "id": "GO:0044877", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044877", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "apolipoprotein A-I binding", "id": "GO:0034186", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034186", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "high-density lipoprotein particle binding", "id": "GO:0008035", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008035", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "phosphatidylethanolamine binding", "id": "GO:0008429", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008429", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "scaffold protein binding", "id": "GO:0097110", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097110", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "lipopolysaccharide binding", "id": "GO:0001530", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001530", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "phosphatidylserine binding", "id": "GO:0001786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001786", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "lipoprotein particle binding", "id": "GO:0071813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071813", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "low-density lipoprotein particle binding", "id": "GO:0030169", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030169", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "protein tyrosine kinase binding", "id": "GO:1990782", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990782", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "lipoteichoic acid binding", "id": "GO:0070891", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070891", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "very-low-density lipoprotein particle binding", "id": "GO:0034189", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034189", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "signaling receptor activity", "id": "GO:0038023", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038023", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "sulfatide binding", "id": "GO:0120146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120146", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" }, { "name": "molecular function activator activity", "id": "GO:0140677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140677", "evidence": [ { "database": "UniProtKB", "id": "Q99NH8", "url": "https://www.uniprot.org/uniprot/Q99NH8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { 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