{
    "uniprot_canonical_ac": "Q99N07-1",
    "uniprot_ac": "Q99N07",
    "uniprot_id": "M4A6D_MOUSE",
    "mass": {
        "chemical_mass": 26383.0,
        "monoisotopic_mass": 26383.0
    },
    "refseq": {
        "ac": "NP_081111",
        "name": "membrane-spanning 4-domains subfamily A member 6D",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081111"
    },
    "gene_names": [
        {
            "name": "Ms4a6d",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q99N07",
            "id": "Q99N07"
        },
        {
            "name": "1110058E16Rik; Ms4a11",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081111",
            "id": "NP_081111"
        },
        {
            "name": "Cd20l8",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q99N07",
            "id": "Q99N07"
        },
        {
            "name": "Ms4a11",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "https://www.uniprot.org/uniprot/Q99N07",
            "id": "Q99N07"
        },
        {
            "name": "Ms4a6d",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081111",
            "id": "NP_081111"
        }
    ],
    "protein_names": [
        {
            "name": "Membrane-spanning 4-domains subfamily A member 6D",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q99N07"
        },
        {
            "name": "CD20 antigen-like 8; membrane-spanning 4-domains, subfamily A, member 11",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081111",
            "id": "NP_081111"
        },
        {
            "name": "CD20 antigen-like 8",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q99N07"
        },
        {
            "name": "membrane-spanning 4-domains subfamily A member 6D",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081111",
            "id": "NP_081111"
        }
    ],
    "function": [
        {
            "annotation": "May be involved in signal transduction as a component of a multimeric receptor complex.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q99N07",
                    "url": "https://www.uniprot.org/uniprot/Q99N07#function"
                }
            ]
        }
    ],
    "disease": [],
    "snv": [],
    "mutagenesis": [],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q99N07",
                    "url": "https://www.uniprot.org/uniprot/Q99N07"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Ms4a6d",
            "url": "https://www.uniprot.org/uniprot/Q99N07",
            "locus": {
                "chromosome": "19",
                "start_pos": 11563968,
                "end_pos": 11582213,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000024679",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000024679"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000024679",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000024679",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "68774",
            "url": "https://www.ncbi.nlm.nih.gov/gene/68774",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR007237",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR007237",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "IPR030417",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR030417",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:68774",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:68774",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "1916024",
            "url": "http://www.informatics.jax.org/marker/MGI:1916024",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "AIQILCG",
            "url": "https://omabrowser.org/oma/group/AIQILCG/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "4641047at2759",
            "url": "http://www.orthodb.org/?query=4641047at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR23320",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23320",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR23320:SF135",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23320:SF135",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PF04103",
            "url": "http://pfam.xfam.org/family/PF04103",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q99N07",
            "url": "http://purl.obolibrary.org/obo/PR_Q99N07",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_081111",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081111",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "F6V7U2",
            "url": "https://www.uniprot.org/uniprot/F6V7U2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "F6V7U2-1",
            "url": "https://www.uniprot.org/uniprot/F6V7U2-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q2TVW7",
            "url": "https://www.uniprot.org/uniprot/Q2TVW7",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q2TVW7-1",
            "url": "https://www.uniprot.org/uniprot/Q2TVW7-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q99N07",
            "url": "https://www.uniprot.org/uniprot/Q99N07",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q99N07-1",
            "url": "https://www.uniprot.org/uniprot/Q99N07-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MIPQVVTSETVTVISPNGISFPQTDKPQPSHQSQDSLKKHLKAEIKVMAAIQIMCAVMVLSLGIILASVPSNLHFTSVFSILLESGYPFVGALFFAISGILSIVTEKKMTKPLVHSSLALSILSVLSALTGIAILSVSLAALEPALQQCKLAFTQLDTTQDAYHFFSPEPLNSCFVAKAALTGVFSLMLISSVLELGLAVLTATLWWKQSSSAFSGNVIFLSQNSKNKSSVSSESLCNPTYENILTS",
        "length": 247,
        "header": "sp|Q99N07-1|M4A6D_MOUSE Isoform 1 of Membrane-spanning 4-domains subfamily A member 6D  OS=Mus musculus OX=10090 GN=Ms4a6d PE=1 SV=1 CANONICAL=Q99N07-1"
    },
    "isoforms": [
        {
            "isoform_ac": "F6V7U2-1",
            "url": "",
            "sequence": {
                "sequence": "MTKPLVHSSLALSILSVLSALTGIAILSVSLAALEPALQQCKLAFTQLDTTQDAYHFFSPEPLNSCFVAKAALTGVFSLMLISSVLELGLAVLTATLWWKQSSSAFSGNVIFLSQNSKNKSSVSSESLCNPTYENILTS",
                "length": 139,
                "header": "tr|F6V7U2-1|M4A6D_MOUSE Computationally mapped isoform of Membrane-spanning 4-domains subfamily A member 6D  OS=Mus musculus OX=10090 GN=Ms4a6d PE=1 SV=2 CANONICAL=Q99N07-1"
            },
            "locus": {
                "chromosome": "19",
                "start_pos": 11570243,
                "end_pos": 11564453,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000125291.3",
                        "url": "https://www.ensembl.org/id/ENSMUST00000125291.3"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000115142.3",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000115142.3"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q2TVW7-1",
            "url": "",
            "sequence": {
                "sequence": "MIPQVVTSETVTVISPNGISFPQTDKPQPSHQSQDSLKKHLKAEIKVMAAIQIMCAVMVLALGIILASVPSNLHFTSVFSILLESGYPFVGALFFAISGILSIVTEKKMTKPLVHSSLALSILSVLSALTGIAILSVSLAALEPALQQCKLAFTQLDTTQDAYHFFSPEPLNSCFVAKAALTGVFSLMLISSVLELGLAVLTATLWWKQSSSAFSGNVIFLSQNSKNKSSVSSESLCNPTYENILTS",
                "length": 247,
                "header": "tr|Q2TVW7-1|M4A6D_MOUSE Computationally mapped isoform of Membrane-spanning 4-domains subfamily A member 6D  OS=Mus musculus OX=10090 GN=Ms4a6d PE=1 SV=1 CANONICAL=Q99N07-1"
            },
            "locus": {
                "chromosome": "19",
                "start_pos": 11580656,
                "end_pos": 11564453,
                "strand": "+",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000025582.11",
                        "url": "https://www.ensembl.org/id/ENSMUST00000025582.11"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000025582.5",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000025582.5"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q99N07-1",
            "url": "",
            "sequence": {
                "sequence": "MIPQVVTSETVTVISPNGISFPQTDKPQPSHQSQDSLKKHLKAEIKVMAAIQIMCAVMVLSLGIILASVPSNLHFTSVFSILLESGYPFVGALFFAISGILSIVTEKKMTKPLVHSSLALSILSVLSALTGIAILSVSLAALEPALQQCKLAFTQLDTTQDAYHFFSPEPLNSCFVAKAALTGVFSLMLISSVLELGLAVLTATLWWKQSSSAFSGNVIFLSQNSKNKSSVSSESLCNPTYENILTS",
                "length": 247,
                "header": "sp|Q99N07-1|M4A6D_MOUSE Isoform 1 of Membrane-spanning 4-domains subfamily A member 6D  OS=Mus musculus OX=10090 GN=Ms4a6d PE=1 SV=1 CANONICAL=Q99N07-1"
            },
            "locus": {}
        }
    ],
    "glycosylation": [],
    "phosphorylation": [
        {
            "start_pos": 232,
            "end_pos": 232,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "Q99N07",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q99N07"
                },
                {
                    "database": "PubMed",
                    "id": "30662948",
                    "url": "https://glygen.org/publication/PubMed/30662948"
                }
            ],
            "site_lbl": "Ser232"
        },
        {
            "start_pos": 235,
            "end_pos": 235,
            "kinase_uniprot_canonical_ac": "",
            "kinase_gene_name": "",
            "residue": "Ser",
            "comment": "Phosphoserine",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q99N07",
                    "url": "https://www.uniprot.org/uniprot/Q99N07"
                },
                {
                    "database": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q99N07",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q99N07"
                },
                {
                    "database": "PubMed",
                    "id": "30662948",
                    "url": "https://glygen.org/publication/PubMed/30662948"
                }
            ],
            "site_lbl": "Ser235"
        }
    ],
    "glycation": [],
    "keywords": [],
    "publication": [
        {
            "title": "Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and beta subunit of the high-affinity IgE receptor.",
            "journal": "Gene",
            "date": "2001",
            "authors": "Ishibashi K, Suzuki M, Sasaki S, Imai M",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q99N07",
                    "url": "https://www.uniprot.org/uniprot/Q99N07"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "11245982",
                    "url": "https://glygen.org/publication/PubMed/11245982"
                }
            ]
        },
        {
            "title": "Identification of a CD20-, Fc-epsilon-RI-beta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse.",
            "journal": "Genomics",
            "date": "2001",
            "authors": "Liang Y., Tedder T.F.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q99N07",
                    "url": "https://www.uniprot.org/uniprot/Q99N07"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "11401424",
                    "url": "https://glygen.org/publication/PubMed/11401424"
                }
            ]
        },
        {
            "title": "A tissue-specific atlas of mouse protein phosphorylation and expression.",
            "journal": "Cell",
            "date": "2010",
            "authors": "Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q99N07",
                    "url": "https://www.uniprot.org/uniprot/Q99N07"
                },
                {
                    "database": "iPTMnet",
                    "id": "Q99N07",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q99N07"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "21183079",
                    "url": "https://glygen.org/publication/PubMed/21183079"
                }
            ]
        },
        {
            "title": "VSIG4 mediates transcriptional inhibition of Nlrp3 and Il-1beta in macrophages.",
            "journal": "Science advances",
            "date": "2019",
            "authors": "Huang X, Feng Z, Jiang Y, Li J, Xiang Q, Guo S, Yang C, Fei L, Guo G, Zheng L, Wu Y, Chen Y",
            "evidence": [
                {
                    "database": "iPTMnet",
                    "id": "Q99N07",
                    "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q99N07"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "30662948",
                    "url": "https://glygen.org/publication/PubMed/30662948"
                }
            ]
        }
    ],
    "pathway": [
        {
            "id": "mmu:68774",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:68774",
            "resource": "KEGG Pathway"
        }
    ],
    "orthologs": [
        {
            "uniprot_canonical_ac": "F1LZT4-1",
            "protein_name": "Membrane spanning 4-domains A6A",
            "gene_name": "Ms4a6a",
            "tax_id": 10116,
            "organism": "Rattus norvegicus",
            "sequence": {
                "sequence": "MIPQVVINDTVTVTSPNGISFPQTDKPQPPHQRQDSLKKHLKAEIKVMAAIQIMCSVMVLALGIILASVPSVPHFTSVFSVLLKSGYPFMGALFFAISGILSVITEKKMTKPLVQCSLALSILSILSALIGLVILSVSLTALEPALQQCKLIATQQPVTTPHYYRFFHHELADKNCFTAKAALTGVFSLMLISSVLELGLAVLTTILWWKQSFSDFSGNVIFLSQDSKNKSSISSESLCNPAYEK",
                "length": 245
            },
            "evidence": [
                {
                    "id": "45230357",
                    "url": "http://www.informatics.jax.org/homology/45230357",
                    "database": "MGI"
                }
            ],
            "common_name": "Rat"
        },
        {
            "uniprot_canonical_ac": "Q96DS6-1",
            "protein_name": "Membrane-spanning 4-domains subfamily A member 6E",
            "gene_name": "MS4A6E",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MTSQPISNETIIMLPSNVINFSQAEKPEPTNQGQDSLKKRLQAKVKVIGVHSSLAGSILSALSALVGFILLSVNPAALNPASLQCKLDEKDIPTRLLLSYDYHSPYTMDCHRAKASLAGTLSLMLVSTVLEFCLAVLTAVLQWKQTV",
                "length": 147
            },
            "evidence": [
                {
                    "id": "45230357",
                    "url": "http://www.informatics.jax.org/homology/45230357",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        },
        {
            "uniprot_canonical_ac": "Q9H2W1-1",
            "protein_name": "Membrane-spanning 4-domains subfamily A member 6A",
            "gene_name": "MS4A6A",
            "tax_id": 9606,
            "organism": "Homo sapiens",
            "sequence": {
                "sequence": "MTSQPVPNETIIVLPSNVINFSQAEKPEPTNQGQDSLKKHLHAEIKVIGTIQILCGMMVLSLGIILASASFSPNFTQVTSTLLNSAYPFIGPFFFIISGSLSIATEKRLTKLLVHSSLVGSILSALSALVGFIILSVKQATLNPASLQCELDKNNIPTRSYVSYFYHDSLYTTDCYTAKASLAGTLSLMLICTLLEFCLAVLTAVLRWKQAYSDFPGSVLFLPHSYIGNSGMSSKMTHDCGYEELLTS",
                "length": 248
            },
            "evidence": [
                {
                    "id": "45230357",
                    "url": "http://www.informatics.jax.org/homology/45230357",
                    "database": "MGI"
                }
            ],
            "common_name": "Human"
        }
    ],
    "go_annotation": {
        "categories": [
            {
                "name": "Cellular Component",
                "total": 3,
                "go_terms": [
                    {
                        "name": "membrane",
                        "id": "GO:0016020",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q99N07",
                                "url": "https://www.uniprot.org/uniprot/Q99N07"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "plasma membrane",
                        "id": "GO:0005886",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q99N07",
                                "url": "https://www.uniprot.org/uniprot/Q99N07"
                            }
                        ],
                        "pmid": ""
                    },
                    {
                        "name": "trans-Golgi network",
                        "id": "GO:0005802",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005802",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q99N07",
                                "url": "https://www.uniprot.org/uniprot/Q99N07"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            },
            {
                "name": "Biological Process",
                "total": 1,
                "go_terms": [
                    {
                        "name": "cell surface receptor signaling pathway",
                        "id": "GO:0007166",
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007166",
                        "evidence": [
                            {
                                "database": "UniProtKB",
                                "id": "Q99N07",
                                "url": "https://www.uniprot.org/uniprot/Q99N07"
                            }
                        ],
                        "pmid": ""
                    }
                ]
            }
        ]
    },
    "pro_annotation": [],
    "site_annotation": [
        {
            "start_pos": 227,
            "end_pos": 229,
            "annotation": "n_glycosylation_sequon"
        }
    ],
    "ptm_annotation": [],
    "interactions": [],
    "reactions": [],
    "reaction_participants": [],
    "reaction_enzymes": [],
    "biomarkers": [],
    "synthesized_glycans": [],
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb",
            "label": "Isoforms"
        },
        {
            "name": "homologset.mgi",
            "label": "MGI Homologs"
        }
    ],
    "section_stats": [
        {
            "table_id": "glycosylation",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
                },
                {
                    "field": "o_linked_glycans",
                    "count": 0
                },
                {
                    "field": "o_linked_glycan_sites",
                    "count": 0
                }
            ],
            "sort_fields": []
        },
        {
            "table_id": "glycosylation_reported",
            "table_stats": [
                {
                    "field": "total",
                    "count": 0
                },
                {
                    "field": "total_sites",
                    "count": 0
                },
                {
                    "field": "n_linked_glycans",
                    "count": 0
                },
                {
                    "field": "n_linked_glycan_sites",
                    "count": 0
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