{ "uniprot_canonical_ac": "Q99KK7-1", "uniprot_ac": "Q99KK7", "uniprot_id": "DPP3_MOUSE", "mass": { "chemical_mass": 82898.0, "monoisotopic_mass": 82898.0 }, "refseq": { "ac": "NP_598564", "name": "dipeptidyl peptidase 3", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598564" }, "gene_names": [ { "name": "Dpp3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q99KK7", "id": "Q99KK7" }, { "name": "4930533O14Rik; DPP III", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598564", "id": "NP_598564" }, { "name": "Dpp3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598564", "id": "NP_598564" } ], "protein_names": [ { "name": "Dipeptidyl peptidase 3", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q99KK7" }, { "name": "3.4.14.4", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q99KK7" }, { "name": "DPP III", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q99KK7" }, { "name": "Dipeptidyl aminopeptidase III", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q99KK7" }, { "name": "Dipeptidyl arylamidase III", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q99KK7" }, { "name": "Dipeptidyl peptidase III", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q99KK7" }, { "name": "Enkephalinase B", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q99KK7" }, { "name": "dipeptidyl peptidase 3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598564", "id": "NP_598564" }, { "name": "dipeptidyl-peptidase 3; dipeptidyl aminopeptidase III; dipeptidyl arylamidase III; dipeptidylpeptidase III; dipeptidyl peptidase III; enkephalinase B", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598564", "id": "NP_598564" } ], "function": [ { "annotation": "Absence of Dipeptidyl Peptidase 3 Increases Oxidative Stress and Causes Bone Loss.", "evidence": [ { "database": "RefSeq", "id": "NP_598564", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598564" }, { "database": "PubMed", "id": "31295380", "url": "https://glygen.org/publication/PubMed/31295380" } ] }, { "annotation": "Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin. Also cleaves Arg-Arg-beta-naphthylamide (in vitro).", "evidence": [ { "database": "UniProtKB", "id": "Q99KK7", "url": "https://www.uniprot.org/uniprot/Q99KK7#function" }, { "database": "UniProtKB", "id": "Q9NY33", "url": "https://www.uniprot.org/uniprot/Q9NY33#function" } ] }, { "annotation": "DPP3 expression promotes cell proliferation and migration in vitro and tumour growth in vivo, which is associated with poor prognosis of oesophageal carcinoma.", "evidence": [ { "database": "RefSeq", "id": "NP_598564", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598564" }, { "database": "PubMed", "id": "36382663", "url": "https://glygen.org/publication/PubMed/36382663" } ] }, { "annotation": "Dipeptidyl peptidase 3 modulates the renin-angiotensin system in mice.", "evidence": [ { "database": "RefSeq", "id": "NP_598564", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598564" }, { "database": "PubMed", "id": "32546481", "url": "https://glygen.org/publication/PubMed/32546481" } ] }, { "annotation": "Dipeptidyl-peptidase 3 protects oxygen-glucose deprivation/reoxygenation-injured hippocampal neurons by suppressing apoptosis, oxidative stress and inflammation via modulation of Keap1/Nrf2 signaling.", "evidence": [ { "database": "RefSeq", "id": "NP_598564", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598564" }, { "database": "PubMed", "id": "33812256", "url": "https://glygen.org/publication/PubMed/33812256" } ] }, { "annotation": "The cellular peptidases dipeptidyl peptidase 3 (DPP-3) and thimet oligopeptidase 1 (TOP-1), both of which are present in nonimmunogenic necrotic cells, eliminated proteasomal degradation products and blocked Ag cross-presentation", "evidence": [ { "database": "RefSeq", "id": "NP_598564", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598564" }, { "database": "PubMed", "id": "24216478", "url": "https://glygen.org/publication/PubMed/24216478" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q99KK7", "url": "https://www.uniprot.org/uniprot/Q99KK7" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Dpp3", "url": "https://www.uniprot.org/uniprot/Q99KK7", "locus": { "chromosome": "19", "start_pos": 4957257, "end_pos": 4978315, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000063904", "url": "https://www.ensembl.org/id/ENSMUSG00000063904" } ] } } ], "crossref": [ { "id": "ENSMUSG00000063904", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000063904", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "75221", "url": "https://www.ncbi.nlm.nih.gov/gene/75221", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR005317", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005317", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039461", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039461", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:75221", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:75221", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1922471", "url": "http://www.informatics.jax.org/marker/MGI:1922471", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "QRYWIRD", "url": "https://omabrowser.org/oma/group/QRYWIRD/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5471561at2759", "url": "http://www.orthodb.org/?query=5471561at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR23422", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23422", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23422:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23422:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF03571", "url": "http://pfam.xfam.org/family/PF03571", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q99KK7", "url": "http://purl.obolibrary.org/obo/PR_Q99KK7", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_598564", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598564", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A494B918", "url": "https://www.uniprot.org/uniprot/A0A494B918", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A494B918-1", "url": "https://www.uniprot.org/uniprot/A0A494B918-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A494BA16", "url": "https://www.uniprot.org/uniprot/A0A494BA16", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A494BA16-1", "url": "https://www.uniprot.org/uniprot/A0A494BA16-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A494BBB3", "url": "https://www.uniprot.org/uniprot/A0A494BBB3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A494BBB3-1", "url": "https://www.uniprot.org/uniprot/A0A494BBB3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A494BBC1", "url": "https://www.uniprot.org/uniprot/A0A494BBC1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A494BBC1-1", "url": "https://www.uniprot.org/uniprot/A0A494BBC1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q99KK7", "url": "https://www.uniprot.org/uniprot/Q99KK7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q99KK7-1", "url": "https://www.uniprot.org/uniprot/Q99KK7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MADTQYILPNDIGVSSLDCREAFRLLSPTERLYAHHLSRAAWYGGLAVLLQTSPEAPYIYALLSRLFRAQDPDQLRQHALAEGLTEEEYQAFLVYAAGVYSNMGNYKSFGDTKFVPNLPKDKLGRVILGSKAAQQRPEEVRDLWQTCGDLMFSLEPRLRHLGLGKEGVTTYFSGDCTMEDAKLAQDFLDSQNLSAYNTRLFKVVGQEGKSHYEVRLASVLNTDPALDSELTSKLKRYEFQGNHFQVTRGDYAPILQKVVEHLEKAKAYAANSHQEQMLAQYVESFTQGSIEAHKRGSRFWIQDKGPIVESYIGFIESYRDPFGSRGEFEGFVAMVNKAMSAKFERLVASAEQLLKELPWPLAFEKDKFLTPDFTSLDVLTFAGSGIPAGINIPNYDDLRQTEGFKNVSLGNVLAVAYAAKREKLTFLEEEDKDLYIRWKGPSFDVQVGLHELLGHGSGKLFVQDEKGAFNFDKETVINPETGEQIQSWYRSGETWDSKFSTIASSYEECRAESVGLYLCLNPQVLEIFGFEGADAEDVIYVNWLNMVRAGLLALEFYTPEAANWRQAHMQARFVILRVLLEAGEGLVTVTPTTGSDGRPDARVRLDRSKIRSVGRPALERFLRRLQVLKSTGDVVAGRALYEGYAAVTDAPPECFLTLRDTVLLRKESRKLIVQPNTRLEGSEVQLVEYEASAAGLIRSFCERFPEDGPELEEVLIQLAAADARFWRNQAQEAPPGQA", "length": 738, "header": "sp|Q99KK7-1|DPP3_MOUSE Isoform 1 of Dipeptidyl peptidase 3 OS=Mus musculus OX=10090 GN=Dpp3 PE=1 SV=2 CANONICAL=Q99KK7-1" }, "isoforms": [ { "isoform_ac": "A0A494B918-1", "url": "", "sequence": { "sequence": "MADTQYILPNDIGVSSLDCREAFRLLSPTERLYAHHLSRAAWYGGLAVLLQTSPEAPYIYALLSRLFRAQDPDQLRQHALAEGLTEEEYQAFLVYAAGVYSNMGNYKSFGDTKFVPNLPKDKLGRVILGSKAAQQRPEEVRDLWQTCGDLMFS", "length": 153, "header": "tr|A0A494B918-1|DPP3_MOUSE Computationally mapped isoform of Dipeptidyl peptidase 3 OS=Mus musculus OX=10090 GN=Dpp3 PE=1 SV=1 CANONICAL=Q99KK7-1" }, "locus": { "chromosome": "19", "start_pos": 4977082, "end_pos": 4973134, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000236758.2", "url": "https://www.ensembl.org/id/ENSMUST00000236758.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000157448.2", "url": "https://www.ensembl.org/id/ENSMUSP00000157448.2" } ] } }, { "isoform_ac": "A0A494BA16-1", "url": "", "sequence": { "sequence": "XAEGLTEEEYQAFLVYAAGVYSNMGNYKSFGDTKFVPNLPKDFLDSQNLSAYNTRLFKVVGQEGKSHYEVRLASVLNTDPALDSELTSKLKRYEFQGNHFQVTRGDYAPILQKVVEHLEKAKAYAANSHQEQMLAQYVESFTQGSIEAHKRGSRFWIQDKGPIVESYIGFIESYRDPFGSRGEFE", "length": 185, "header": "tr|A0A494BA16-1|DPP3_MOUSE Computationally mapped isoform of Dipeptidyl peptidase 3 OS=Mus musculus OX=10090 GN=Dpp3 PE=1 SV=1 CANONICAL=Q99KK7-1" }, "locus": { "chromosome": "19", "start_pos": 4976844, "end_pos": 4967900, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000236496.2", "url": "https://www.ensembl.org/id/ENSMUST00000236496.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000157895.2", "url": "https://www.ensembl.org/id/ENSMUSP00000157895.2" } ] } }, { "isoform_ac": "A0A494BBB3-1", "url": "", "sequence": { "sequence": "MADTQYILPNDIGVSSLDCREAFRLLSPTERLYAHHLSRAAWYGGLAVLLQTSPEAPYIYALLSRLFRAQDPDQLRQHALAEGLTEEEYQAFLVYAAGVYSNMGNYKSFGDTKFVPNLPKDKLGRVILGSKAAQQRPEEVRDLWQTCGDLMFSLEPRLRHLGLGKEGVTTYFSGDCTMEDAKLAQDFLDSQ", "length": 191, "header": "tr|A0A494BBB3-1|DPP3_MOUSE Computationally mapped isoform of Dipeptidyl peptidase 3 OS=Mus musculus OX=10090 GN=Dpp3 PE=1 SV=1 CANONICAL=Q99KK7-1" }, "locus": { "chromosome": "19", "start_pos": 4977082, "end_pos": 4972350, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000237394.2", "url": "https://www.ensembl.org/id/ENSMUST00000237394.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000158386.2", "url": "https://www.ensembl.org/id/ENSMUSP00000158386.2" } ] } }, { "isoform_ac": "A0A494BBC1-1", "url": "", "sequence": { "sequence": "MADTQYILPNDIGVSSLDCREAFRLLSPTERLYAHHLSRAAWYGGLAVLLQTSPEAPYIYALLSRLFRAQDPDQLRQHALAEGLTEEEYQAFLVYAAGVYSNMGNYKSFGDTKFVPNLPKDKLGRVILGSKAAQQRPEEVRDLWQTCGDLMFSLEPRLRHLGLGKEGVTTYFSGDCTMEDAKLAQDFLDSQNLSAYNTRLFKVVGQEGKSHYEVRLASVLNTDPALDSELTSKLKRYEFQGNHFQVTRGDYAPILQKVVEHLEKAKAYAANSHQEQMLAQYVESFTQGSIEAHKRGSRFWIQDKGPIVESYIGFIESYRDPFGSRGEFEGFVAMVNKAMSAKFERLVASAEQLLKELPWPLAFEKDKFLTPDFTSLDVLTFAGSGIPAGINIPNYDDLRQTEGFKNVSLGNVLAVAYAAKREKLTFLEEEDKDLYIRWKGPSFDVQVLSTLTRRL", "length": 455, "header": "tr|A0A494BBC1-1|DPP3_MOUSE Computationally mapped isoform of Dipeptidyl peptidase 3 OS=Mus musculus OX=10090 GN=Dpp3 PE=1 SV=1 CANONICAL=Q99KK7-1" }, "locus": { "chromosome": "19", "start_pos": 4977082, "end_pos": 4965073, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000235781.2", "url": "https://www.ensembl.org/id/ENSMUST00000235781.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000158453.2", "url": "https://www.ensembl.org/id/ENSMUSP00000158453.2" } ] } }, { "isoform_ac": "Q99KK7-1", "url": "", "sequence": { "sequence": "MADTQYILPNDIGVSSLDCREAFRLLSPTERLYAHHLSRAAWYGGLAVLLQTSPEAPYIYALLSRLFRAQDPDQLRQHALAEGLTEEEYQAFLVYAAGVYSNMGNYKSFGDTKFVPNLPKDKLGRVILGSKAAQQRPEEVRDLWQTCGDLMFSLEPRLRHLGLGKEGVTTYFSGDCTMEDAKLAQDFLDSQNLSAYNTRLFKVVGQEGKSHYEVRLASVLNTDPALDSELTSKLKRYEFQGNHFQVTRGDYAPILQKVVEHLEKAKAYAANSHQEQMLAQYVESFTQGSIEAHKRGSRFWIQDKGPIVESYIGFIESYRDPFGSRGEFEGFVAMVNKAMSAKFERLVASAEQLLKELPWPLAFEKDKFLTPDFTSLDVLTFAGSGIPAGINIPNYDDLRQTEGFKNVSLGNVLAVAYAAKREKLTFLEEEDKDLYIRWKGPSFDVQVGLHELLGHGSGKLFVQDEKGAFNFDKETVINPETGEQIQSWYRSGETWDSKFSTIASSYEECRAESVGLYLCLNPQVLEIFGFEGADAEDVIYVNWLNMVRAGLLALEFYTPEAANWRQAHMQARFVILRVLLEAGEGLVTVTPTTGSDGRPDARVRLDRSKIRSVGRPALERFLRRLQVLKSTGDVVAGRALYEGYAAVTDAPPECFLTLRDTVLLRKESRKLIVQPNTRLEGSEVQLVEYEASAAGLIRSFCERFPEDGPELEEVLIQLAAADARFWRNQAQEAPPGQA", "length": 738, "header": "sp|Q99KK7-1|DPP3_MOUSE Isoform 1 of Dipeptidyl peptidase 3 OS=Mus musculus OX=10090 GN=Dpp3 PE=1 SV=2 CANONICAL=Q99KK7-1" }, "locus": { "chromosome": "19", "start_pos": 4977082, "end_pos": 4957653, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000025851", "url": "https://www.ensembl.org/id/ENSMUST00000025851" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000025851", "url": "https://www.ensembl.org/id/ENSMUSP00000025851" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Peptidases released by necrotic cells control CD8+ T cell cross-priming.", "journal": "The Journal of clinical investigation", "date": "2013", "authors": "Gamrekelashvili J, Kapanadze T, Han M, Wissing J, Ma C, Jaensch L, Manns MP, Armstrong T, Jaffee E, White AO, Citrin DE, Korangy F, Greten TF", "evidence": [ { "database": "RefSeq", "id": "NP_598564", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598564" } ], "reference": [ { "type": "PubMed", "id": "24216478", "url": "https://glygen.org/publication/PubMed/24216478" } ] }, { "title": "Absence of Dipeptidyl Peptidase 3 Increases Oxidative Stress and Causes Bone Loss.", "journal": "Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research", "date": "2019", "authors": "Menale C, Robinson LJ, Palagano E, Rigoni R, Erreni M, Almarza AJ, Strina D, Mantero S, Lizier M, Forlino A, Besio R, Monari M, Vezzoni P, Cassani B, Blair HC, Villa A, Sobacchi C", "evidence": [ { "database": "RefSeq", "id": "NP_598564", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598564" } ], "reference": [ { "type": "PubMed", "id": "31295380", "url": "https://glygen.org/publication/PubMed/31295380" } ] }, { "title": "Dipeptidyl peptidase 3 modulates the renin-angiotensin system in mice.", "journal": "The Journal of biological chemistry", "date": "2020", "authors": "Jha S, Taschler U, Domenig O, Poglitsch M, Bourgeois B, Pollheimer M, Pusch LM, Malovan G, Frank S, Madl T, Gruber K, Zimmermann R, Macheroux P", "evidence": [ { "database": "RefSeq", "id": "NP_598564", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598564" } ], "reference": [ { "type": "PubMed", "id": "32546481", "url": "https://glygen.org/publication/PubMed/32546481" } ] }, { "title": "Dipeptidyl-peptidase 3 protects oxygen-glucose deprivation/reoxygenation-injured hippocampal neurons by suppressing apoptosis, oxidative stress and inflammation via modulation of Keap1/Nrf2 signaling.", "journal": "International immunopharmacology", "date": "2021", "authors": "Ren X, Yu J, Guo L, Ma H", "evidence": [ { "database": "RefSeq", "id": "NP_598564", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598564" } ], "reference": [ { "type": "PubMed", "id": "33812256", "url": "https://glygen.org/publication/PubMed/33812256" } ] }, { "title": "DPP3 expression promotes cell proliferation and migration in\u00a0vitro and tumour growth in\u00a0vivo, which is associated with poor prognosis of oesophageal carcinoma.", "journal": "Oncology reports", "date": "2023-01", "authors": "Liu Jing-Kun, Abudula Abulizi, Yang Hai-Tao, Xu Li-Xiu, Nuerrula Yiliyaer, Bai Ge, Tulahong Aisiker, Eli Maynur", "evidence": [ { "database": "RefSeq", "id": "NP_598564", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_598564" } ], "reference": [ { "type": "PubMed", "id": "36382663", "url": "https://glygen.org/publication/PubMed/36382663" } ] } ], "pathway": [ { "id": "mmu:75221", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:75221", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "O55096-1", "protein_name": "Dipeptidyl peptidase 3", "gene_name": "Dpp3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MADTQYILPNDIGVSSLDCREAFRLLSPTERLYAHHLSRAAWYGGLAVLLQTSPEAPYIYALLSRLFRAQDPDQLRQHALAEGLTEEEYQAFLVYAAGVYSNMGNYKSFGDTKFVPNLPKEKLERVILGSKAAQQHPEEVRSLWQTCGELMFSLEPRLRHLGLGKEGVTTYFSGDCAMEDAKLAQDFLDSQNLSAYNTRLFKVVGQEGKYHYEVRLASVLNTEPALDSELTSKLKSYEFQGNHFQVTRGDYAPILQKVVEHLEKAKAYAANSHQEQMLAQYVESFTQGSIEAHKRGSRFWIQDKGPIVESYIGFIESYRDPFGSRGEFEGFVAMVNKDMSAKFERLVASAEQLLKELPWPPAFEKDKFLTPDFTSLDVLTFAGSGIPAGINIPNYDDLRQTEGFKNVSLGNVLAVAYATKREKLTFMEEEDKDLYIRWKGPSFDVQVGLHELLGHGSGKLFVQDEKGAFNFDQETVINPETGEQIQSWYRSGETWDSKFSTIASSYEECRAESVGLYLCLNPQVLQIFGFEGTDAEDVIYVNWLNMVRAGLLALEFYTPETANWRQAHMQARFVILRVLLEAGEGLVTVTPTTGSDGRPDARVHLDRSKIRSVGKPALERFLRRLQVLKSTGDVVAGRALYEGYAAVTDAPPECFLTLRDTVLLRKESRKLIVQPNTRLEGSEVQLVEYEASAAGLIRSFCERFPEDGPELEEVLTQLATADAQFWRDQVQEAPSGQA", "length": 738 }, "evidence": [ { "id": "45225679", "url": "http://www.informatics.jax.org/homology/45225679", "database": "MGI" }, { "id": "Q99KK7", "url": "https://omabrowser.org/oma/group/Q99KK7/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q08225-1", "protein_name": "Probable dipeptidyl peptidase 3", "gene_name": "", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MSHFFADHDAPLSMLSVKTEYFPQLTDKEQKYAHFMSKASHAGSRVVMRQVSHESEPIFDLILAIHSKLNGKYPEDDITQKQQTGLYLEYVSQFLSNLGNFKSFGDTKFIPRCEVKFFKQLLELAKINPCSSPLTLSPVDVNHEFTSHHLFSTINELIDIGIYHVEEKAALLGFPSQGYTSAYYLGLPVTPEDMALLKEQLFAELAILPENTRINKVGENSFQIWVASENVKNQITETYPSGQITLSNAVTKVEFIFGDHSREMRLVASYLKEAQKFAANDTQKAMLQEYINHFVTGSSQAHKEAQKLWVKDISPVIETNIGFIETYREPSGIIGEFESLVAIQNKERTAKFSSLVNNAEEFISLLPWSKDYEKPIFNPPDFTSLEVLTFTGSGIPAGINIPNYDDVRLKIGFKNVSLGNILSAAAKSSSKHPPSFISQEDRPIFEKYQSDSFEVQVGIHELLGHGSGKLLTEFTDGFNFDKENPPLGLDGKPVSTYYKVGETWGSKFGQLAGPFEECRAEVIAMFLLTNKKILDIFGFHDVESQDKVIYAGYLQMARAGLLALEYWNPKTGKWGQPHMQARFSIMKTFMKHSTDKNFLKLEMNSTNDDFAIKLDKSLIKTAGHECVKDYLKHLHVYKCSGDVEQGSKYFIDRSTVTPDLASLRDIVLSKRLPRRQFIQSNSYIDDNNKVTLKEYDETPQGMLQSFLDREL", "length": 711 }, "evidence": [ { "id": "Q99KK7", "url": "https://omabrowser.org/oma/group/Q99KK7/", "database": "OMA" } ], "common_name": "Yeast" }, { "uniprot_canonical_ac": "Q9NY33-1", "protein_name": "Dipeptidyl peptidase 3", "gene_name": "DPP3", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": "MADTQYILPNDIGVSSLDCREAFRLLSPTERLYAYHLSRAAWYGGLAVLLQTSPEAPYIYALLSRLFRAQDPDQLRQHALAEGLTEEEYQAFLVYAAGVYSNMGNYKSFGDTKFVPNLPKEKLERVILGSEAAQQHPEEVRGLWQTCGELMFSLEPRLRHLGLGKEGITTYFSGNCTMEDAKLAQDFLDSQNLSAYNTRLFKEVDGEGKPYYEVRLASVLGSEPSLDSEVTSKLKSYEFRGSPFQVTRGDYAPILQKVVEQLEKAKAYAANSHQGQMLAQYIESFTQGSIEAHKRGSRFWIQDKGPIVESYIGFIESYRDPFGSRGEFEGFVAVVNKAMSAKFERLVASAEQLLKELPWPPTFEKDKFLTPDFTSLDVLTFAGSGIPAGINIPNYDDLRQTEGFKNVSLGNVLAVAYATQREKLTFLEEDDKDLYILWKGPSFDVQVGLHELLGHGSGKLFVQDEKGAFNFDQETVINPETGEQIQSWYRSGETWDSKFSTIASSYEECRAESVGLYLCLHPQVLEIFGFEGADAEDVIYVNWLNMVRAGLLALEFYTPEAFNWRQAHMQARFVILRVLLEAGEGLVTITPTTGSDGRPDARVRLDRSKIRSVGKPALERFLRRLQVLKSTGDVAGGRALYEGYATVTDAPPECFLTLRDTVLLRKESRKLIVQPNTRLEGSDVQLLEYEASAAGLIRSFSERFPEDGPELEEILTQLATADARFWKGPSEAPSGQA", "length": 737 }, "evidence": [ { "id": "45225679", "url": "http://www.informatics.jax.org/homology/45225679", "database": "MGI" } ], "common_name": "Human" }, { "uniprot_canonical_ac": "Q9VHR8-1", "protein_name": "Dipeptidyl peptidase 3", "gene_name": "DppIII", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MFWLRGLQRSRQQLNRLCHFRSRLNYGTSPSIRSVQPSISRSLGFCSSLVRYSCSTNLPQPAEMASKTAHFVLPNTQPIADLDCKSAFENLTEKEKLYAHHFSQASWDGGLIALIQSSPEAPLIFSLLHRIFLAEKIPVLRAKALEAGVSADDFTAFLVYACGVFANAGNYKGMGDSKIVPNLSEKQFETIVKASAAYSDEPRVGKIFEKVKNLIYALESRNEILGFAPDGITTYWSDNCTKEDSEIVNAWLTSKRIEPYMCRTFKIVENGQTVYDVKLGSVAESTQDGITLPLEEYNGNKFRVTRGDYQKLLQRVNQHLLQAQKYAANENESKMIEHYVRSFEQGSLDEHKNGSRWWIKDKGPVIETYIGFIETYRDPAGGRAEFEGFVAMVNKESSAKFSELVNRAEKLIEYLPWTEPYEKDSYLKPDFTSLDVLTFAGSGVPAGINIPNYDEIRQDEGFKNVSLGNVLANINRKDPIPFLTEEDQTLMKEYKVKAFEVQVGLHELLGHGSGKLFRIDENGVYNFDKENTKNLVTGEPITKWYLPGETYDTKFGAIGSSYEECRAEAVGLYLSLQRDILEIFGFKDKAEQDNIIYVNWLSLIWNGMGVALEMFNPKSKLWLQAHSRARFVIMKVLLEAGEGLVKVEETEKGKNLLLTVDRSKIDTVGRKALGDFLTKLQVYKSTADIEAASKMYEHYSKVDESGSHPWAKWRDICLAHKKPRMILVQANTAIGQDQKVQLKTYEPTHEGYIQSWVERYPNTDIDDLLESIVEKDKKYFPTAFNN", "length": 786 }, "evidence": [ { "id": "Q99KK7", "url": "https://omabrowser.org/oma/group/Q99KK7/", "database": "OMA" } ], "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "Q99KK7", "url": "https://www.uniprot.org/uniprot/Q99KK7" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q99KK7", "url": "https://www.uniprot.org/uniprot/Q99KK7" } ], "pmid": "" }, { "name": "dipeptidyl-peptidase activity", "id": "GO:0008239", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008239", "evidence": [ { "database": "UniProtKB", "id": "Q99KK7", "url": "https://www.uniprot.org/uniprot/Q99KK7" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "Q99KK7", "url": "https://www.uniprot.org/uniprot/Q99KK7" } ], "pmid": "" }, { "name": "aminopeptidase activity", "id": "GO:0004177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004177", "evidence": [ { "database": "UniProtKB", "id": "Q99KK7", "url": "https://www.uniprot.org/uniprot/Q99KK7" } ], "pmid": "" }, { "name": "metalloexopeptidase activity", "id": "GO:0008235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008235", "evidence": [ { "database": "UniProtKB", "id": "Q99KK7", "url": "https://www.uniprot.org/uniprot/Q99KK7" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q99KK7", "url": "https://www.uniprot.org/uniprot/Q99KK7" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q99KK7", "url": "https://www.uniprot.org/uniprot/Q99KK7" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "Q99KK7", "url": "https://www.uniprot.org/uniprot/Q99KK7" } ], "pmid": "" }, { "name": "protein catabolic process", "id": "GO:0030163", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030163", "evidence": [ { "database": "UniProtKB", "id": "Q99KK7", "url": "https://www.uniprot.org/uniprot/Q99KK7" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 192, "end_pos": 194, "annotation": "n_glycosylation_sequon" }, { "start_pos": 406, "end_pos": 408, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 5 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }