{
    "uniprot_canonical_ac": "Q99K23-1",
    "uniprot_ac": "Q99K23",
    "uniprot_id": "UFSP2_MOUSE",
    "mass": {
        "chemical_mass": 52515.0,
        "monoisotopic_mass": 52515.0
    },
    "refseq": {
        "ac": "NP_619609",
        "name": "ufm1-specific protease 2",
        "summary": "",
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_619609"
    },
    "gene_names": [
        {
            "name": "Ufsp2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "https://www.uniprot.org/uniprot/Q99K23",
            "id": "Q99K23"
        },
        {
            "name": "1810047C23Rik",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_619609",
            "id": "NP_619609"
        },
        {
            "name": "Ufsp2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_619609",
            "id": "NP_619609"
        }
    ],
    "protein_names": [
        {
            "name": "Ufm1-specific protease 2",
            "resource": "UniProtKB",
            "type": "recommended",
            "url": "",
            "id": "Q99K23"
        },
        {
            "name": "3.4.22.-",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q99K23"
        },
        {
            "name": "UfSP2",
            "resource": "UniProtKB",
            "type": "synonym",
            "url": "",
            "id": "Q99K23"
        },
        {
            "name": "ufm1-specific protease 2",
            "resource": "RefSeq",
            "type": "synonym",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_619609",
            "id": "NP_619609"
        }
    ],
    "function": [
        {
            "annotation": "Structure of ubiquitin-fold modifier 1-specific protease UfSP2.",
            "evidence": [
                {
                    "database": "RefSeq",
                    "id": "NP_619609",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_619609"
                },
                {
                    "database": "PubMed",
                    "id": "21228277",
                    "url": "https://glygen.org/publication/PubMed/21228277"
                }
            ]
        },
        {
            "annotation": "Thiol-dependent isopeptidase that recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins (PubMed:17182609, PubMed:21228277). Through TRIP4 deufmylation may regulate intracellular nuclear receptors transactivation and thereby regulate cell proliferation and differentiation (By similarity).",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q99K23",
                    "url": "https://www.uniprot.org/uniprot/Q99K23#function"
                },
                {
                    "database": "UniProtKB",
                    "id": "Q9NUQ7",
                    "url": "https://www.uniprot.org/uniprot/Q9NUQ7#function"
                },
                {
                    "database": "PubMed",
                    "id": "21228277",
                    "url": "https://glygen.org/publication/PubMed/21228277"
                },
                {
                    "database": "PubMed",
                    "id": "17182609",
                    "url": "https://glygen.org/publication/PubMed/17182609"
                }
            ]
        }
    ],
    "disease": [
        {
            "disease_id": "DOID:0050709",
            "recommended_name": {
                "id": "DOID:0050709",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0050709",
                "name": "early infantile epileptic encephalopathy",
                "description": "A neonatal period electroclinical syndrome that is characterized by tonic spasms and partial seizures."
            },
            "synonyms": [
                {
                    "id": "DOID:0050709",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0050709",
                    "name": "Early Infantile Epileptic Encephalopathy with Burst-Suppression",
                    "description": ""
                }
            ],
            "evidence": [
                {
                    "id": "0050709",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0050709"
                }
            ]
        },
        {
            "disease_id": "DOID:0070392",
            "recommended_name": {
                "id": "DOID:0070392",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0070392",
                "name": "developmental and epileptic encephalopathy 106",
                "description": "A developmental and epileptic encephalopathy characterized by onset of various types of frequent seizures within the first year of life and profound global developmental delay with limited ability to move and absent speech that has_material_basis_in homozygous mutation in the UFSP2 gene on chromosome 4q35."
            },
            "synonyms": [
                {
                    "id": "DOID:0070392",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0070392",
                    "name": "DEE106",
                    "description": ""
                },
                {
                    "id": "DOID:0070392",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0070392",
                    "name": "early infantile epileptic encephalopathy 106",
                    "description": ""
                },
                {
                    "id": "MONDO:0031052",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0031052",
                    "name": "developmental and epileptic encephalopathy 106",
                    "description": ""
                },
                {
                    "id": "MONDO:0031052",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0031052",
                    "name": "DEE106",
                    "description": ""
                },
                {
                    "id": "MONDO:0031052",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0031052",
                    "name": "developmental and epileptic encephalopathy 106",
                    "description": ""
                },
                {
                    "id": "MIM:620028",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/620028",
                    "name": "Developmental and epileptic encephalopathy 106",
                    "description": "Developmental and epileptic encephalopathy 106"
                }
            ],
            "evidence": [
                {
                    "id": "0070392",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0070392"
                }
            ]
        },
        {
            "disease_id": "DOID:0111367",
            "recommended_name": {
                "id": "DOID:0111367",
                "resource": "Disease Ontology",
                "url": "http://disease-ontology.org/term/DOID:0111367",
                "name": "Beukes hip dysplasia",
                "description": "An osteoarthritis characterized by bilateral dysmorphism of the proximal femur resulting in severe progressive degenerative osteoarthritis of the hip joint in early adulthood that has_material_basis_in heterozygous mutation in UFSP2 on chromosome 4q35.1."
            },
            "synonyms": [
                {
                    "id": "DOID:0111367",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111367",
                    "name": "BFHD",
                    "description": ""
                },
                {
                    "id": "DOID:0111367",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111367",
                    "name": "Beukes familial hip dysplasia",
                    "description": ""
                },
                {
                    "id": "DOID:0111367",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111367",
                    "name": "Beukes type hip dysplasia",
                    "description": ""
                },
                {
                    "id": "DOID:0111367",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111367",
                    "name": "Cilliers-Beighton syndrome",
                    "description": ""
                },
                {
                    "id": "DOID:0111367",
                    "resource": "Disease Ontology",
                    "url": "http://disease-ontology.org/term/DOID:0111367",
                    "name": "Premature degenerative osteoarthropathy of the hip",
                    "description": ""
                },
                {
                    "id": "MONDO:0007726",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007726",
                    "name": "hip dysplasia, Beukes type",
                    "description": "Beukes familial hip dysplasia (BFHD) is a primary bone dysplasia, characterized by premature degenerative arthropathy of the hip. The disease presents with hip joint discomfort/pain and gait disturbances that usually develops in childhood and that progresses to severe functional disability and limited mobility by early adulthood. Involvement of the vertebral bodies and other joints is minimal, height is not significantly reduced, and general health is unimpaired. Radiographically, the femoral heads are flattened and irregular and degenerative osteoarthritis develops in the hip joints, as evidenced by the presence of periarticular cysts, sclerosis, and joint space narrowing."
                },
                {
                    "id": "MONDO:0007726",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007726",
                    "name": "BFHD",
                    "description": ""
                },
                {
                    "id": "MONDO:0007726",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007726",
                    "name": "Beukes familial hip dysplasia",
                    "description": ""
                },
                {
                    "id": "MONDO:0007726",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007726",
                    "name": "Cilliers-Beighton syndrome",
                    "description": ""
                },
                {
                    "id": "MONDO:0007726",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007726",
                    "name": "hip dysplasia, Beukes type",
                    "description": ""
                },
                {
                    "id": "MONDO:0007726",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007726",
                    "name": "premature degenerative osteoarthropathy of the hip",
                    "description": ""
                },
                {
                    "id": "MONDO:0007726",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007726",
                    "name": "BHD",
                    "description": ""
                },
                {
                    "id": "MONDO:0007726",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007726",
                    "name": "Beukes hip dysplasia",
                    "description": ""
                },
                {
                    "id": "MONDO:0007726",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007726",
                    "name": "hip dysplasia Beukes type",
                    "description": ""
                },
                {
                    "id": "MONDO:0007726",
                    "resource": "MONDO",
                    "url": "https://monarchinitiative.org/disease/MONDO:0007726",
                    "name": "osteoarthropathy, premature degenerative, of hip",
                    "description": ""
                },
                {
                    "id": "MIM:142669",
                    "resource": "MIM",
                    "url": "https://www.omim.org/entry/142669",
                    "name": "Beukes familial hip dysplasia",
                    "description": "Beukes familial hip dysplasia"
                }
            ],
            "evidence": [
                {
                    "id": "0111367",
                    "database": "Alliance of Genome Resources",
                    "url": "https://www.alliancegenome.org/disease/DOID:0111367"
                }
            ]
        }
    ],
    "snv": [],
    "mutagenesis": [
        {
            "start_pos": 282,
            "end_pos": 282,
            "sequence_org": "Y",
            "sequence_mut": "H",
            "comment": "Loss of enzyme activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q99K23",
                    "url": "https://www.uniprot.org/uniprot/Q99K23"
                },
                {
                    "database": "PubMed",
                    "id": "21228277",
                    "url": "https://glygen.org/publication/PubMed/21228277"
                }
            ]
        },
        {
            "start_pos": 294,
            "end_pos": 294,
            "sequence_org": "C",
            "sequence_mut": "S",
            "comment": "Loss of enzyme activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q99K23",
                    "url": "https://www.uniprot.org/uniprot/Q99K23"
                },
                {
                    "database": "PubMed",
                    "id": "21228277",
                    "url": "https://glygen.org/publication/PubMed/21228277"
                },
                {
                    "database": "PubMed",
                    "id": "17182609",
                    "url": "https://glygen.org/publication/PubMed/17182609"
                }
            ]
        },
        {
            "start_pos": 398,
            "end_pos": 398,
            "sequence_org": "H",
            "sequence_mut": "A",
            "comment": "No effect on enzyme activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q99K23",
                    "url": "https://www.uniprot.org/uniprot/Q99K23"
                },
                {
                    "database": "PubMed",
                    "id": "21228277",
                    "url": "https://glygen.org/publication/PubMed/21228277"
                }
            ]
        },
        {
            "start_pos": 418,
            "end_pos": 418,
            "sequence_org": "D",
            "sequence_mut": "A",
            "comment": "Reduced enzyme activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q99K23",
                    "url": "https://www.uniprot.org/uniprot/Q99K23"
                },
                {
                    "database": "PubMed",
                    "id": "21228277",
                    "url": "https://glygen.org/publication/PubMed/21228277"
                }
            ]
        },
        {
            "start_pos": 420,
            "end_pos": 420,
            "sequence_org": "H",
            "sequence_mut": "A",
            "comment": "Loss of enzyme activity.",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q99K23",
                    "url": "https://www.uniprot.org/uniprot/Q99K23"
                },
                {
                    "database": "PubMed",
                    "id": "21228277",
                    "url": "https://glygen.org/publication/PubMed/21228277"
                }
            ]
        }
    ],
    "expression_tissue": [],
    "expression_disease": [],
    "species": [
        {
            "name": "Mus musculus",
            "taxid": 10090,
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q99K23",
                    "url": "https://www.uniprot.org/uniprot/Q99K23"
                }
            ],
            "common_name": "Mouse"
        }
    ],
    "gene": [
        {
            "name": "Ufsp2",
            "url": "https://www.uniprot.org/uniprot/Q99K23",
            "locus": {
                "chromosome": "8",
                "start_pos": 46449995,
                "end_pos": 46428565,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Gene",
                        "id": "ENSMUSG00000031634",
                        "url": "https://www.ensembl.org/id/ENSMUSG00000031634"
                    }
                ]
            }
        }
    ],
    "crossref": [
        {
            "id": "ENSMUSG00000031634",
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000031634",
            "database": "Bgee",
            "categories": [
                "Gene Expression"
            ]
        },
        {
            "id": "192169",
            "url": "https://www.ncbi.nlm.nih.gov/gene/192169",
            "database": "GeneID",
            "categories": [
                "Genome Annotation"
            ]
        },
        {
            "id": "IPR012462",
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR012462",
            "database": "InterPro",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "mmu:192169",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:192169",
            "database": "KEGG Pathway",
            "categories": [
                "Enzyme and Pathway"
            ]
        },
        {
            "id": "1913679",
            "url": "http://www.informatics.jax.org/marker/MGI:1913679",
            "database": "MGI",
            "categories": [
                "Organism-specific"
            ]
        },
        {
            "id": "ETTGHIK",
            "url": "https://omabrowser.org/oma/group/ETTGHIK/",
            "database": "OMA",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "11265at2759",
            "url": "http://www.orthodb.org/?query=11265at2759",
            "database": "OrthoDB",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR48153",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48153",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PTHR48153:SF2",
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR48153:SF2",
            "database": "PANTHER",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "3OQC",
            "url": "https://www.rcsb.org/structure/3OQC",
            "database": "PDB",
            "categories": [
                "3D Structure"
            ]
        },
        {
            "id": "PF07910",
            "url": "http://pfam.xfam.org/family/PF07910",
            "database": "Pfam",
            "categories": [
                "Protein Classification"
            ]
        },
        {
            "id": "PR_Q99K23",
            "url": "http://purl.obolibrary.org/obo/PR_Q99K23",
            "database": "PRO",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "NP_619609",
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_619609",
            "database": "RefSeq",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A1B0GQY6",
            "url": "https://www.uniprot.org/uniprot/A0A1B0GQY6",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A1B0GQY6-1",
            "url": "https://www.uniprot.org/uniprot/A0A1B0GQY6-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A1B0GRT2",
            "url": "https://www.uniprot.org/uniprot/A0A1B0GRT2",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A1B0GRT2-1",
            "url": "https://www.uniprot.org/uniprot/A0A1B0GRT2-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A1B0GSK1",
            "url": "https://www.uniprot.org/uniprot/A0A1B0GSK1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A1B0GSK1-1",
            "url": "https://www.uniprot.org/uniprot/A0A1B0GSK1-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A1B0GSM1",
            "url": "https://www.uniprot.org/uniprot/A0A1B0GSM1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A1B0GSM1-1",
            "url": "https://www.uniprot.org/uniprot/A0A1B0GSM1-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A1B0GSY4",
            "url": "https://www.uniprot.org/uniprot/A0A1B0GSY4",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "A0A1B0GSY4-1",
            "url": "https://www.uniprot.org/uniprot/A0A1B0GSY4-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q99K23",
            "url": "https://www.uniprot.org/uniprot/Q99K23",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        },
        {
            "id": "Q99K23-1",
            "url": "https://www.uniprot.org/uniprot/Q99K23-1",
            "database": "UniProtKB",
            "categories": [
                "Protein"
            ]
        }
    ],
    "sequence": {
        "sequence": "MDILFRIRGGFDLAFQLAPPKEMFIKNALRQVLSDLTTKLSSDALVLRVCNSSVYLWPNSDANTGELTDSSACKNVVRFIQFDQEEDTKRKFIKKKDKKLTDTQQIVNIDLMLEISTPLGAVTPILERENEEHHYINMSLPIDAVVSVAPEESWGKVRKLLVDAILRQLVDVEKCILRYMKGTSIVVPEPLHFQLPGKKNLVTVLYPSGIPDDQLQAYRKELHDLFNLPHDRPYFKRINAYHFPDELYKDGYIRNPHTYLSPPNIEGSMICVVQGTYAYHHYMQDRIDDNGWGCAYRSLQTICSWFRHQGYTERSIPTHREIQQALVDAGDKPATFVGSRQWIGSIEVQMVLNQLIGVTSKILFVNQGSEMASQGRELANHFQNVGTPVMVGGGVLAHTILGVAWNETTGQIKFLILDPHYTGAEDLQVMLEKGWCGWKSPDFWNKDAYYNLCLPQRPNAL",
        "length": 461,
        "header": "sp|Q99K23-1|UFSP2_MOUSE Isoform 1 of Ufm1-specific protease 2  OS=Mus musculus OX=10090 GN=Ufsp2 PE=1 SV=1 CANONICAL=Q99K23-1"
    },
    "isoforms": [
        {
            "isoform_ac": "A0A1B0GQY6-1",
            "url": "",
            "sequence": {
                "sequence": "MDILFRIRGGFDLAFQLAPPKEMFIKNALRQVLSDLTTKLSSDA",
                "length": 44,
                "header": "tr|A0A1B0GQY6-1|A0A1B0GQY6_MOUSE Computationally mapped isoform of UFM1-specific peptidase 2  OS=Mus musculus OX=10090 GN=Ufsp2 PE=1 SV=1 CANONICAL=Q99K23-1"
            },
            "locus": {
                "chromosome": "8",
                "start_pos": 46433419,
                "end_pos": 46432269,
                "strand": "-",
                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000150943.2",
                        "url": "https://www.ensembl.org/id/ENSMUST00000150943.2"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000147305.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000147305.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "A0A1B0GRT2-1",
            "url": "",
            "sequence": {
                "sequence": "MDILFRIRGGFDLAFQLAPPKEMFIKNALRQVLSDLTTKLSSDALVLRVCNSSVYLWPNSDANTGELTDSSAYLIKRRIQSENSLKRKTKS",
                "length": 91,
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                        "id": "ENSMUST00000210081.2",
                        "url": "https://www.ensembl.org/id/ENSMUST00000210081.2"
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                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000147651.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000147651.2"
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        {
            "isoform_ac": "A0A1B0GSK1-1",
            "url": "",
            "sequence": {
                "sequence": "MDILFRIRGGFDLAFQLAPPKEMFIKNALRQVLSDLTTKLSSDALVLRVCNSSVYLWPNSDANTGELTDSSACKNVVRFIQFDQEEDTKRKFIKKKDKKLTDTSAQTSSGCNSQAAS",
                "length": 117,
                "header": "tr|A0A1B0GSK1-1|A0A1B0GSK1_MOUSE Computationally mapped isoform of UFM1-specific peptidase 2  OS=Mus musculus OX=10090 GN=Ufsp2 PE=1 SV=1 CANONICAL=Q99K23-1"
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                "evidence": [
                    {
                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000123307.8",
                        "url": "https://www.ensembl.org/id/ENSMUST00000123307.8"
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                        "id": "ENSMUSP00000147971.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000147971.2"
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            "isoform_ac": "A0A1B0GSM1-1",
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                "sequence": "MDILFRIRGGFDLAFQLAPPKEMFIKNALRQVLSDLTTKLSSDALVLRVCNSSVYLWPNSDANTGELTDSSACKNVVRFIQVRKLLVDAILRQLVDVEKCILRYMKGTSIVVPEPLHFQLPGKKNLVTVLYPSGIPDDQLQAYRKELHDLFNLPHDRPYFKRINAYHFPDELYKDGYIRNPHTYLSPPNIEGSMVSLIRHLCLSSLYARSD",
                "length": 211,
                "header": "tr|A0A1B0GSM1-1|A0A1B0GSM1_MOUSE Computationally mapped isoform of UFM1-specific peptidase 2  OS=Mus musculus OX=10090 GN=Ufsp2 PE=1 SV=1 CANONICAL=Q99K23-1"
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                "chromosome": "8",
                "start_pos": 46444837,
                "end_pos": 46432269,
                "strand": "-",
                "evidence": [
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                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000209443.2",
                        "url": "https://www.ensembl.org/id/ENSMUST00000209443.2"
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                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000147993.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000147993.2"
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                ]
            }
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        {
            "isoform_ac": "A0A1B0GSY4-1",
            "url": "",
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                "sequence": "MDILFRIRGGFDLAFQLAPPKEMFIKNALRQVLSDLTTKLSSDALVLRVCNSSVYLWPNSDANTGELTDSSACKNVVRFIQ",
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                "header": "tr|A0A1B0GSY4-1|A0A1B0GSY4_MOUSE Computationally mapped isoform of UFM1-specific peptidase 2  OS=Mus musculus OX=10090 GN=Ufsp2 PE=1 SV=1 CANONICAL=Q99K23-1"
            },
            "locus": {
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                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000130412.8",
                        "url": "https://www.ensembl.org/id/ENSMUST00000130412.8"
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                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000148122.2",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000148122.2"
                    }
                ]
            }
        },
        {
            "isoform_ac": "Q99K23-1",
            "url": "",
            "sequence": {
                "sequence": "MDILFRIRGGFDLAFQLAPPKEMFIKNALRQVLSDLTTKLSSDALVLRVCNSSVYLWPNSDANTGELTDSSACKNVVRFIQFDQEEDTKRKFIKKKDKKLTDTQQIVNIDLMLEISTPLGAVTPILERENEEHHYINMSLPIDAVVSVAPEESWGKVRKLLVDAILRQLVDVEKCILRYMKGTSIVVPEPLHFQLPGKKNLVTVLYPSGIPDDQLQAYRKELHDLFNLPHDRPYFKRINAYHFPDELYKDGYIRNPHTYLSPPNIEGSMICVVQGTYAYHHYMQDRIDDNGWGCAYRSLQTICSWFRHQGYTERSIPTHREIQQALVDAGDKPATFVGSRQWIGSIEVQMVLNQLIGVTSKILFVNQGSEMASQGRELANHFQNVGTPVMVGGGVLAHTILGVAWNETTGQIKFLILDPHYTGAEDLQVMLEKGWCGWKSPDFWNKDAYYNLCLPQRPNAL",
                "length": 461,
                "header": "sp|Q99K23-1|UFSP2_MOUSE Isoform 1 of Ufm1-specific protease 2  OS=Mus musculus OX=10090 GN=Ufsp2 PE=1 SV=1 CANONICAL=Q99K23-1"
            },
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                "start_pos": 46449822,
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                "strand": "-",
                "evidence": [
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                        "database": "Ensembl Transcript",
                        "id": "ENSMUST00000034051",
                        "url": "https://www.ensembl.org/id/ENSMUST00000034051"
                    },
                    {
                        "database": "Ensembl Peptide",
                        "id": "ENSMUSP00000034051",
                        "url": "https://www.ensembl.org/id/ENSMUSP00000034051"
                    }
                ]
            }
        }
    ],
    "glycosylation": [],
    "phosphorylation": [],
    "glycation": [],
    "keywords": [
        "enzyme"
    ],
    "publication": [
        {
            "title": "Two novel ubiquitin-fold modifier 1 (Ufm1)-specific Proteases, UfSP1 and UfSP2.",
            "journal": "J. Biol. Chem.",
            "date": "2007",
            "authors": "Kang SH, Kim GR, Seong M, Baek SH, Seol JH, Bang OS, Ovaa H, Tatsumi K, Komatsu M, Tanaka K, Chung CH",
            "evidence": [
                {
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                    "id": "Q99K23",
                    "url": "https://www.uniprot.org/uniprot/Q99K23"
                }
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                {
                    "type": "PubMed",
                    "id": "17182609",
                    "url": "https://glygen.org/publication/PubMed/17182609"
                }
            ]
        },
        {
            "title": "Structure of Ubiquitin-fold modifier 1 specific protease, UfSP2.",
            "journal": "J. Biol. Chem.",
            "date": "2011",
            "authors": "Ha BH, Jeon YJ, Shin SC, Tatsumi K, Komatsu M, Tanaka K, Watson CM, Wallis G, Chung CH, Kim EE",
            "evidence": [
                {
                    "database": "UniProtKB",
                    "id": "Q99K23",
                    "url": "https://www.uniprot.org/uniprot/Q99K23"
                },
                {
                    "database": "RefSeq",
                    "id": "NP_619609",
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_619609"
                }
            ],
            "reference": [
                {
                    "type": "PubMed",
                    "id": "21228277",
                    "url": "https://glygen.org/publication/PubMed/21228277"
                }
            ]
        },
        {
            "title": "A pathogenic UFSP2 variant in an autosomal recessive form of pediatric neurodevelopmental anomalies and epilepsy.",
            "journal": "Genet. Med.",
            "date": "2021",
            "authors": "Ni Min, Afroze Bushra, Xing Chao, Pan Chunxiao, Shao Yanqiu, Cai Ling, Cantarel Brandi L, Pei Jimin, Grishin Nick V, Hewson Stacy, Knight Devon, Mahida Sonal, Michel Donnice, Tarnopolsky Mark, Poduri Annapurna, Rotenberg Alexander, Sondheimer Neal, DeBerardinis Ralph J",
            "evidence": [
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                {
                    "type": "PubMed",
                    "id": "33473208",
                    "url": "https://glygen.org/publication/PubMed/33473208"
                }
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            "id": "mmu:192169",
            "name": "",
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:192169",
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                        "name": "nucleus",
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            "name": "homologset.mgi",
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            "name": "homologset.oma",
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