{ "uniprot_canonical_ac": "Q96KP6-1", "uniprot_ac": "Q96KP6", "uniprot_id": "TNIP3_HUMAN", "mass": { "chemical_mass": 38943.0, "monoisotopic_mass": 38943.0 }, "refseq": { "ac": "NP_001122315", "name": "TNFAIP3-interacting protein 3 isoform 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001122315" }, "gene_names": [ { "name": "TNIP3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q96KP6", "id": "Q96KP6" }, { "name": "ABIN-3; LIND", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001122315", "id": "NP_001122315" }, { "name": "ABIN3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q96KP6", "id": "Q96KP6" }, { "name": "LIND", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q96KP6", "id": "Q96KP6" }, { "name": "TNIP3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001122315", "id": "NP_001122315" } ], "protein_names": [ { "name": "TNFAIP3-interacting protein 3", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q96KP6" }, { "name": "A20-binding inhibitor of NF-kappa-B activation 3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q96KP6" }, { "name": "ABIN-3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q96KP6" }, { "name": "Listeria induced; TNIP3 beta; ABIN-3 beta; TNFAIP3-interacting protein 3 beta; listeria-induced gene protein; A20-binding inhibitor of NF-kappa-B activation 3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001122315", "id": "NP_001122315" }, { "name": "Listeria-induced gene protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q96KP6" }, { "name": "TNFAIP3-interacting protein 3 isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001122315", "id": "NP_001122315" } ], "function": [ { "annotation": "ABIN-3 is a novel negative feedback regulator of LPS-induced NF-kappaB activation", "evidence": [ { "database": "RefSeq", "id": "NP_001122315", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001122315" }, { "database": "PubMed", "id": "17088249", "url": "https://glygen.org/publication/PubMed/17088249" } ] }, { "annotation": "ABIN-3 is, thus, an IL-10-induced gene product capable of attenuating NF-kappaB in human macrophages yet is inoperative in mice and represents a basis for species-specific differences in IL-10 actions.", "evidence": [ { "database": "RefSeq", "id": "NP_001122315", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001122315" }, { "database": "PubMed", "id": "17485448", "url": "https://glygen.org/publication/PubMed/17485448" } ] }, { "annotation": "Binds to zinc finger protein TNFAIP3 and inhibits NF-kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13-acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding.", "evidence": [ { "database": "UniProtKB", "id": "Q96KP6", "url": "https://www.uniprot.org/uniprot/Q96KP6#function" }, { "database": "PubMed", "id": "17088249", "url": "https://glygen.org/publication/PubMed/17088249" } ] }, { "annotation": "Elevated TNIP3 mRNA Expression in TNF-alpha-Secreting Cells from Patients with Major Depressive Disorder.", "evidence": [ { "database": "RefSeq", "id": "NP_001122315", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001122315" }, { "database": "PubMed", "id": "31307045", "url": "https://glygen.org/publication/PubMed/31307045" } ] }, { "annotation": "Enhanced expression of ABIN-3 in monocytes is associated with sepsis", "evidence": [ { "database": "RefSeq", "id": "NP_001122315", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001122315" }, { "database": "PubMed", "id": "18081698", "url": "https://glygen.org/publication/PubMed/18081698" } ] }, { "annotation": "TNFAIP3 Interacting Protein 3 Overexpression Suppresses Nonalcoholic Steatohepatitis by Blocking TAK1 Activation.", "evidence": [ { "database": "RefSeq", "id": "NP_001122315", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001122315" }, { "database": "PubMed", "id": "32268115", "url": "https://glygen.org/publication/PubMed/32268115" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "Q96KP6", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q96KP6" } ], "glycoeffect": [], "start_pos": 156, "end_pos": 156, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "E", "sequence_mut": "K", "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (3).", "chr_id": "4", "chr_pos": "121154577", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "E156", "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", 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"https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] }, { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] } ], "mutagenesis": 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"MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", 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"MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "Q96KP6", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q96KP6" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "No", "trend": "up", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "Q96KP6", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q96KP6" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": 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"name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q96KP6", "url": "https://www.uniprot.org/uniprot/Q96KP6" } ], "common_name": "Human" } ], "gene": [ { "name": "TNIP3", "url": "https://www.uniprot.org/uniprot/Q96KP6", "locus": { "chromosome": "4", "start_pos": 121131408, "end_pos": 121227466, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000050730", "url": "https://www.ensembl.org/id/ENSG00000050730" } ] } } ], "crossref": [ { "id": "ENSG00000050730", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000050730", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "Q96KP6", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q96KP6", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "cd09803", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09803", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "TNIP3", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=TNIP3", "database": "GeneCards", "categories": [ "Organism-specific", "Gene Annotation" ] }, { "id": "79931", "url": "https://www.ncbi.nlm.nih.gov/gene/79931", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "19315", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=19315", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "Q96KP6", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q96KP6*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR032419", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032419", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:79931", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:79931", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "608019", "url": "http://www.omim.org/entry/608019", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_Q96KP6", "url": "https://www.nextprot.org/entry/NX_Q96KP6", "database": "neXtProt", "categories": [ "Organism-specific", "Protein" ] }, { "id": "PDYQWHA", "url": "https://omabrowser.org/oma/group/PDYQWHA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "4245801at2759", "url": "http://www.orthodb.org/?query=4245801at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR31882", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31882", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR31882:SF2", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31882:SF2", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF16516", "url": "http://pfam.xfam.org/family/PF16516", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "Q96KP6", "url": "https://pharos.nih.gov/targets/Q96KP6", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_Q96KP6", "url": "http://purl.obolibrary.org/obo/PR_Q96KP6", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-5689896", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689896", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001122315", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001122315", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "H0Y9J7", "url": "https://www.uniprot.org/uniprot/H0Y9J7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0Y9J7-1", "url": "https://www.uniprot.org/uniprot/H0Y9J7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q96KP6", "url": "https://www.uniprot.org/uniprot/Q96KP6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q96KP6-1", "url": "https://www.uniprot.org/uniprot/Q96KP6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q96KP6-2", "url": "https://www.uniprot.org/uniprot/Q96KP6-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q96KP6-3", "url": "https://www.uniprot.org/uniprot/Q96KP6-3", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAHFVQGTSRMIAAESSTEHKECAEPSTRKNLMNSLEQKIRCLEKQRKELLEVNQQWDQQFRSMKELYERKVAELKTKLDAAERFLSTREKDPHQRQRKDDRQREDDRQRDLTRDRLQREEKEKERLNEELHELKEENKLLKGKNTLANKEKEHYECEIKRLNKALQDALNIKCSFSEDCLRKSRVEFCHEEMRTEMEVLKQQVQIYEEDFKKERSDRERLNQEKEELQQINETSQSQLNRLNSQIKACQMEKEKLEKQLKQMYCPPCNCGLVFHLQDPWVPTGPGAVQKQREHPPDYQWYALDQLPPDVQHKANGLSSVKKVHP", "length": 325, "header": "sp|Q96KP6-1|TNIP3_HUMAN Isoform 1 of TNFAIP3-interacting protein 3 OS=Homo sapiens OX=9606 GN=TNIP3 PE=1 SV=2 CANONICAL=Q96KP6-1" }, "isoforms": [ { "isoform_ac": "H0Y9J7-1", "url": "", "sequence": { "sequence": "CNCGLVFHLQDPWVPTGPGAVQKQREHPPDYQWYALDQLPPDVQHKANESAILSTACFYGLVRPPRSGLYKLSYNQNPTSILIKYT", "length": 86, "header": "tr|H0Y9J7-1|TNIP3_HUMAN Computationally mapped isoform of TNFAIP3-interacting protein 3 OS=Homo sapiens OX=9606 GN=TNIP3 PE=1 SV=1 CANONICAL=Q96KP6-1" }, "locus": { "chromosome": "4", "start_pos": 121141899, "end_pos": 121137903, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000515036.1", "url": "https://www.ensembl.org/id/ENST00000515036.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000424284.1", "url": "https://www.ensembl.org/id/ENSP00000424284.1" } ] } }, { "isoform_ac": "Q96KP6-1", "url": "", "sequence": { "sequence": "MAHFVQGTSRMIAAESSTEHKECAEPSTRKNLMNSLEQKIRCLEKQRKELLEVNQQWDQQFRSMKELYERKVAELKTKLDAAERFLSTREKDPHQRQRKDDRQREDDRQRDLTRDRLQREEKEKERLNEELHELKEENKLLKGKNTLANKEKEHYECEIKRLNKALQDALNIKCSFSEDCLRKSRVEFCHEEMRTEMEVLKQQVQIYEEDFKKERSDRERLNQEKEELQQINETSQSQLNRLNSQIKACQMEKEKLEKQLKQMYCPPCNCGLVFHLQDPWVPTGPGAVQKQREHPPDYQWYALDQLPPDVQHKANGLSSVKKVHP", "length": 325, "header": "sp|Q96KP6-1|TNIP3_HUMAN Isoform 1 of TNFAIP3-interacting protein 3 OS=Homo sapiens OX=9606 GN=TNIP3 PE=1 SV=2 CANONICAL=Q96KP6-1" }, "locus": { "chromosome": "4", "start_pos": 121164125, "end_pos": 121132634, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000057513.8", "url": "https://www.ensembl.org/id/ENST00000057513.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000057513.3", "url": "https://www.ensembl.org/id/ENSP00000057513.3" } ] } }, { "isoform_ac": "Q96KP6-2", "url": "", "sequence": { "sequence": "MNKNEKHDDKLVMFTNQSEDSERCESMELDKKIQDLIERNASPHPKRFTPEAMPTHRNLCSLKTPGKTASMAHFVQGTSRMIAAESSTEHKECAEPSTRKNLMNSLEQKIRCLEKQRKELLEVNQQWDQQFRSMKELYERKVAELKTKLDAAERFLSTREKDPHQRQRKDDRQREDDRQRDLTRDRLQREEKEKERLNEELHELKEENKLLKGKNTLANKEKEHYECEIKRLNKALQDALNIKCSFSEDCLRKSRVEFCHEEMRTEMEVLKQQVQIYEEDFKKERSDRERLNQEKEELQQINETSQSQLNRLNSQIKACQMEKEKLEKQLKQMYCPPCNCGLVFHLQDPWVPTGPGAVQKQREHPVYPQ", "length": 369, "header": "sp|Q96KP6-2|TNIP3_HUMAN Isoform 2 of TNFAIP3-interacting protein 3 OS=Homo sapiens OX=9606 GN=TNIP3 PE=1 SV=2 CANONICAL=Q96KP6-1" }, "locus": { "chromosome": "4", "start_pos": 121216482, "end_pos": 121132651, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000507879.5", "url": "https://www.ensembl.org/id/ENST00000507879.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000427106.1", "url": "https://www.ensembl.org/id/ENSP00000427106.1" } ] } }, { "isoform_ac": "Q96KP6-3", "url": "", "sequence": { "sequence": "MIPCGWLMNKNEKHDDKLVMFTNQSEDSERCESMELDKKIQDLIERNASPHPKRFTPEAMPTHRNLCSLKTPGKTASMAHFVQGTSRMIAAESSTEHKECAEPSTRKNLMNSLEQKIRCLEKQRKELLEVNQQWDQQFRSMKELYERKVAELKTKLDAAERFLSTREKDPHQRQRKDDRQREDDRQRDLTRDRLQREEKEKERLNEELHELKEENKLLKGKNTLANKEKEHYECEIKRLNKALQDALNIKCSFSEDCLRKSRVEFCHEEMRTEMEVLKQQVQIYEEDFKKERSDRERLNQEKEELQQINETSQSQLNRLNSQIKACQMEKEKLEKQLKQMYCPPCNCGLVFHLQDPWVPTGPGAVQKQREHPVYPQ", "length": 376, "header": "sp|Q96KP6-3|TNIP3_HUMAN Isoform 3 of TNFAIP3-interacting protein 3 OS=Homo sapiens OX=9606 GN=TNIP3 PE=1 SV=2 CANONICAL=Q96KP6-1" }, "locus": { "chromosome": "4", "start_pos": 121227387, "end_pos": 121132651, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000509841.1", "url": "https://www.ensembl.org/id/ENST00000509841.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000426613.1", "url": "https://www.ensembl.org/id/ENSP00000426613.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN.", "journal": "The Journal of cell biology", "date": "1999", "authors": "Heyninck K, De Valck D, Vanden Berghe W, Van Criekinge W, Contreras R, Fiers W, Haegeman G, Beyaert R", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689896", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689896" } ], "reference": [ { "type": "PubMed", "id": "10385526", "url": "https://glygen.org/publication/PubMed/10385526" } ] }, { "title": "Two novel genes FIND and LIND differentially expressed in deactivated and Listeria-infected human macrophages.", "journal": "Immunogenetics", "date": "2001", "authors": "Brauchlin A., Schaffner A., Schoedon G., Staege H.", "evidence": [ { "database": "UniProtKB", "id": "Q96KP6", "url": "https://www.uniprot.org/uniprot/Q96KP6" } ], "reference": [ { "type": "PubMed", "id": "11345586", "url": "https://glygen.org/publication/PubMed/11345586" } ] }, { "title": "Isolation and characterization of two novel A20-like proteins.", "journal": "The Biochemical journal", "date": "2001", "authors": "Evans PC, Taylor ER, Coadwell J, Heyninck K, Beyaert R, Kilshaw PJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689896", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689896" } ], "reference": [ { "type": "PubMed", "id": "11463333", "url": "https://glygen.org/publication/PubMed/11463333" } ] }, { "title": "Two isoforms of otubain 1 regulate T cell anergy via GRAIL.", "journal": "Nature immunology", "date": "2004", "authors": "Soares L, Seroogy C, Skrenta H, Anandasabapathy N, Lovelace P, Chung CD, Engleman E, Fathman CG", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689896", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689896" } ], "reference": [ { "type": "PubMed", "id": "14661020", "url": "https://glygen.org/publication/PubMed/14661020" } ] }, { "title": "De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling.", "journal": "Nature", "date": "2004", "authors": "Wertz IE, O'Rourke KM, Zhou H, Eby M, Aravind L, Seshagiri S, Wu P, Wiesmann C, Baker R, Boone DL, Ma A, Koonin EV, Dixit VM", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689896", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689896" } ], "reference": [ { "type": "PubMed", "id": "15258597", "url": "https://glygen.org/publication/PubMed/15258597" } ] }, { "title": "The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses.", "journal": "Nature immunology", "date": "2004", "authors": "Boone DL, Turer EE, Lee EG, Ahmad RC, Wheeler MT, Tsui C, Hurley P, Chien M, Chai S, Hitotsumatsu O, McNally E, Pickart C, Ma A", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689896", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689896" } ], "reference": [ { "type": "PubMed", "id": "15334086", "url": "https://glygen.org/publication/PubMed/15334086" } ] }, { "title": "LIND/ABIN-3 is a novel lipopolysaccharide-inducible inhibitor of NF-kappaB activation.", "journal": "J. Biol. Chem.", "date": "2007", "authors": "Wullaert A, Verstrepen L, Van Huffel S, Adib-Conquy M, Cornelis S, Kreike M, Haegman M, El Bakkouri K, Sanders M, Verhelst K, Carpentier I, Cavaillon JM, Heyninck K, Beyaert R", "evidence": [ { "database": "UniProtKB", "id": "Q96KP6", "url": "https://www.uniprot.org/uniprot/Q96KP6" }, { "database": "RefSeq", "id": "NP_001122315", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001122315" } ], "reference": [ { "type": "PubMed", "id": "17088249", "url": "https://glygen.org/publication/PubMed/17088249" } ] }, { "title": "ABIN-3: a molecular basis for species divergence in interleukin-10-induced anti-inflammatory actions.", "journal": "Molecular and cellular biology", "date": "2007", "authors": "Weaver BK, Bohn E, Judd BA, Gil MP, Schreiber RD", "evidence": [ { "database": "RefSeq", "id": "NP_001122315", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001122315" } ], "reference": [ { "type": "PubMed", "id": "17485448", "url": "https://glygen.org/publication/PubMed/17485448" } ] }, { "title": "Expression of the NF-kappaB inhibitor ABIN-3 in response to TNF and toll-like receptor 4 stimulation is itself regulated by NF-kappaB.", "journal": "Journal of cellular and molecular medicine", "date": "2008", "authors": "Verstrepen L, Adib-Conquy M, Kreike M, Carpentier I, Adrie C, Cavaillon JM, Beyaert R", "evidence": [ { "database": "RefSeq", "id": "NP_001122315", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001122315" } ], "reference": [ { "type": "PubMed", "id": "18081698", "url": "https://glygen.org/publication/PubMed/18081698" } ] }, { "title": "Ubiquitin binding mediates the NF-kappaB inhibitory potential of ABIN proteins.", "journal": "Oncogene", "date": "2008", "authors": "Wagner S, Carpentier I, Rogov V, Kreike M, Ikeda F, Lohr F, Wu CJ, Ashwell JD, Dotsch V, Dikic I, Beyaert R", "evidence": [ { "database": "UniProtKB", "id": "Q96KP6", "url": "https://www.uniprot.org/uniprot/Q96KP6" } ], "reference": [ { "type": "PubMed", "id": "18212736", "url": "https://glygen.org/publication/PubMed/18212736" } ] }, { "title": "OTU Domain-containing ubiquitin aldehyde-binding protein 1 (OTUB1) deubiquitinates estrogen receptor (ER) alpha and affects ERalpha transcriptional activity.", "journal": "The Journal of biological chemistry", "date": "2009", "authors": "Stanisic V, Malovannaya A, Qin J, Lonard DM, O'Malley BW", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689896", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689896" } ], "reference": [ { "type": "PubMed", "id": "19383985", "url": "https://glygen.org/publication/PubMed/19383985" } ] }, { "title": "ABINs: A20 binding inhibitors of NF-kappa B and apoptosis signaling.", "journal": "Biochemical pharmacology", "date": "2009", "authors": "Verstrepen L, Carpentier I, Verhelst K, Beyaert R", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689896", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689896" } ], "reference": [ { "type": "PubMed", "id": "19464428", "url": "https://glygen.org/publication/PubMed/19464428" } ] }, { "title": "The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER.", "journal": "Molecular cell", "date": "2009", "authors": "Ernst R, Mueller B, Ploegh HL, Schlieker C", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689896", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689896" } ], "reference": [ { "type": "PubMed", "id": "19818707", "url": "https://glygen.org/publication/PubMed/19818707" } ] }, { "title": "Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6.", "journal": "The Journal of biological chemistry", "date": "2010", "authors": "Li S, Zheng H, Mao AP, Zhong B, Li Y, Liu Y, Gao Y, Ran Y, Tien P, Shu HB", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689896", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689896" } ], "reference": [ { "type": "PubMed", "id": "19996094", "url": "https://glygen.org/publication/PubMed/19996094" } ] }, { "title": "Post-translational modification of the deubiquitinating enzyme otubain 1 modulates active RhoA levels and susceptibility to Yersinia invasion.", "journal": "The FEBS journal", "date": "2010", "authors": "Edelmann MJ, Kramer HB, Altun M, Kessler BM", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689896", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689896" } ], "reference": [ { "type": "PubMed", "id": "20553488", "url": "https://glygen.org/publication/PubMed/20553488" } ] }, { "title": "Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1.", "journal": "The EMBO journal", "date": "2012", "authors": "Sun XX, Challagundla KB, Dai MS", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689896", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689896" } ], "reference": [ { "type": "PubMed", "id": "22124327", "url": "https://glygen.org/publication/PubMed/22124327" } ] }, { "title": "OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis.", "journal": "Cell", "date": "2013", "authors": "Mevissen TE, Hospenthal MK, Geurink PP, Elliott PR, Akutsu M, Arnaudo N, Ekkebus R, Kulathu Y, Wauer T, El Oualid F, Freund SM, Ovaa H, Komander D", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689896", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5689896" } ], "reference": [ { "type": "PubMed", "id": "23827681", "url": "https://glygen.org/publication/PubMed/23827681" } ] }, { "title": "Structural basis for ovarian tumor domain-containing protein 1 (OTU1) binding to p97/valosin-containing protein (VCP).", "journal": "The Journal of biological chemistry", "date": "2014", "authors": "Kim SJ, Cho J, Song EJ, Kim SJ, Kim HM, Lee KE, Suh SW, Kim EE", "evidence": [ { "database": "Reactome", "id": "R-HSA-5689896", "url": 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