{ "uniprot_canonical_ac": "Q96DH6-1", "uniprot_ac": "Q96DH6", "uniprot_id": "MSI2H_HUMAN", "mass": { "chemical_mass": 35197.0, "monoisotopic_mass": 35197.0 }, "refseq": { "ac": "NP_620412", "name": "RNA-binding protein Musashi homolog 2 isoform a", "summary": "This gene encodes an RNA-binding protein that is a member of the Musashi protein family. The encoded protein is transcriptional regulator that targets genes involved in development and cell cycle regulation. Mutations in this gene are associated with poor prognosis in certain types of cancers. This gene has also been shown to be rearranged in certain cancer cells. [provided by RefSeq, Apr 2016].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620412" }, "gene_names": [ { "name": "MSI2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q96DH6", "id": "Q96DH6" }, { "name": "MSI2H", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620412", "id": "NP_620412" }, { "name": "MSI2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620412", "id": "NP_620412" } ], "protein_names": [ { "name": "RNA-binding protein Musashi homolog 2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q96DH6" }, { "name": "Musashi-2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q96DH6" }, { "name": "RNA-binding protein Musashi homolog 2 isoform a", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620412", "id": "NP_620412" }, { "name": "RNA-binding protein Musashi homolog 2 isoform c", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001309179", "id": "NP_001309179" }, { "name": "RNA-binding protein Musashi homolog 2; musashi-2; musashi homolog 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001309179", "id": "NP_001309179" } ], "function": [ { "annotation": "Dysregulated Stem Cell Markers Musashi-1 and Musashi-2 are Associated with Therapy Resistance in Inflammatory Breast Cancer.", "evidence": [ { "database": "RefSeq", "id": "NP_001309179", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001309179" }, { "database": "PubMed", "id": "37481823", "url": "https://glygen.org/publication/PubMed/37481823" }, { "database": "RefSeq", "id": "NP_620412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620412" } ] }, { "annotation": "MSI2 has a crucial role in both normal and malignant hematopoiesis.", "evidence": [ { "database": "RefSeq", "id": "NP_001309179", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001309179" }, { "database": "PubMed", "id": "20823875", "url": "https://glygen.org/publication/PubMed/20823875" }, { "database": "RefSeq", "id": "NP_620412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620412" } ] }, { "annotation": "Msi2 expression is not only highly upregulated during human chronic myeloid leukemia progression but is also an early indicator of poorer prognosis", "evidence": [ { "database": "RefSeq", "id": "NP_001309179", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001309179" }, { "database": "PubMed", "id": "20639863", "url": "https://glygen.org/publication/PubMed/20639863" }, { "database": "RefSeq", "id": "NP_620412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620412" } ] }, { "annotation": "Prognostic value of MSI2 expression in human malignancies: A PRISMA-compliant meta-analysis.", "evidence": [ { "database": "RefSeq", "id": "NP_001309179", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001309179" }, { "database": "PubMed", "id": "36596017", "url": "https://glygen.org/publication/PubMed/36596017" }, { "database": "RefSeq", "id": "NP_620412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620412" } ] }, { "annotation": "RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q96DH6", "url": "https://www.uniprot.org/uniprot/Q96DH6#function" } ] }, { "annotation": "TP53 mutations and RNA-binding protein MUSASHI-2 drive resistance to PRMT5-targeted therapy in B-cell lymphoma. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001309179", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001309179" }, { "database": "PubMed", "id": "36167829", "url": "https://glygen.org/publication/PubMed/36167829" }, { "database": "RefSeq", "id": "NP_620412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620412" } ] }, { "annotation": "The EVI1 gene locus was rearranged in all 13 myeloid malignancies patients and was associated with EVI1 overexpression. In 9 out of 13 patients, the 17q breakpoints clustered in a 250 kb region on band 17q22 encompassing the MSI2 gene", "evidence": [ { "database": "RefSeq", "id": "NP_001309179", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001309179" }, { "database": "PubMed", "id": "18815193", "url": "https://glygen.org/publication/PubMed/18815193" }, { "database": "RefSeq", "id": "NP_620412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620412" } ] }, { "annotation": "The TGF-beta/Smad2/3 signaling pathway is involved in Musashi2-induced invasion and metastasis of colorectal cancer.", "evidence": [ { "database": "RefSeq", "id": "NP_001309179", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001309179" }, { "database": "PubMed", "id": "36345938", "url": "https://glygen.org/publication/PubMed/36345938" }, { "database": "RefSeq", "id": "NP_620412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620412" } ] }, { "annotation": "Theoretical studies on RNA recognition by Musashi 1 RNA-binding protein. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001309179", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001309179" }, { "database": "PubMed", "id": "35840700", "url": "https://glygen.org/publication/PubMed/35840700" }, { "database": "RefSeq", "id": "NP_620412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620412" } ] }, { "annotation": "This gene encodes an RNA-binding protein that is a member of the Musashi protein family. The encoded protein is transcriptional regulator that targets genes involved in development and cell cycle regulation. Mutations in this gene are associated with poor prognosis in certain types of cancers. This gene has also been shown to be rearranged in certain cancer cells. [provided by RefSeq, Apr 2016].", "evidence": [ { "database": "RefSeq", "id": "NP_001309179", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001309179" }, { "database": "RefSeq", "id": "NP_620412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620412" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "95.76", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000153944", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000153944" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "88.01", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000153944", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000153944" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "94.16", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000153944", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000153944" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "86.69", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000153944", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000153944" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "89.11", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000153944", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000153944" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "92.74", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000153944", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000153944" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "91.22", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000153944", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000153944" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "89.18", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000153944", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000153944" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "90.92", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000153944", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000153944" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "88.26", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000153944", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000153944" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "Q96DH6", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q96DH6" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "Q96DH6", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q96DH6" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "No", "trend": "up", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "Q96DH6", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q96DH6" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Head and neck cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "Q96DH6", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q96DH6" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Lung cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1324", "evidence": [ { "database": "BioXpress", "id": "Q96DH6", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q96DH6" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": 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"UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A6Q8PHT3", "url": "https://www.uniprot.org/uniprot/A0A6Q8PHT3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A6Q8PHT3-1", "url": "https://www.uniprot.org/uniprot/A0A6Q8PHT3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B4DHE8", "url": "https://www.uniprot.org/uniprot/B4DHE8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B4DHE8-1", "url": "https://www.uniprot.org/uniprot/B4DHE8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B4DM51", "url": "https://www.uniprot.org/uniprot/B4DM51", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B4DM51-1", "url": "https://www.uniprot.org/uniprot/B4DM51-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "J3KTC1", "url": "https://www.uniprot.org/uniprot/J3KTC1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "J3KTC1-1", "url": "https://www.uniprot.org/uniprot/J3KTC1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "J3QKT5", "url": "https://www.uniprot.org/uniprot/J3QKT5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "J3QKT5-1", "url": "https://www.uniprot.org/uniprot/J3QKT5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q96DH6", "url": "https://www.uniprot.org/uniprot/Q96DH6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q96DH6-1", "url": "https://www.uniprot.org/uniprot/Q96DH6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q96DH6-2", "url": "https://www.uniprot.org/uniprot/Q96DH6-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q96DH6-3", "url": "https://www.uniprot.org/uniprot/Q96DH6-3", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEANGSQGTSGSANDSQHDPGKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQFPGFPAAAYGPVAAAAVAAARGSGSNPARPGGFPGANSPGPVADLYGPASQDSGVGNYISAASPQPGSGFGHGIAGPLIATAFTNGYH", "length": 328, "header": "sp|Q96DH6-1|MSI2H_HUMAN Isoform 1 of RNA-binding protein Musashi homolog 2 OS=Homo sapiens OX=9606 GN=MSI2 PE=1 SV=1 CANONICAL=Q96DH6-1" }, "isoforms": [ { "isoform_ac": "A0A6Q8PF05-1", "url": "", "sequence": { "sequence": "NDSQHDPGKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQFPALLPYLNASFPAAAYGPVAAAAVAAARGSVLNSYSAQPNFGAPASPAGSNPARPGGFPGANSPGPVADLYGPASQDSGVGNYISAASPQPGSGFGHGIAGPLIATAFTNGYH", "length": 341, "header": "tr|A0A6Q8PF05-1|A0A6Q8PF05_HUMAN Computationally mapped isoform of Musashi RNA binding protein 2 OS=Homo sapiens OX=9606 GN=MSI2 PE=1 SV=1 CANONICAL=Q96DH6-1" }, "locus": { "chromosome": "17", "start_pos": 57677025, "end_pos": 57256782, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000675656.1", "url": "https://www.ensembl.org/id/ENST00000675656.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000501595.1", "url": "https://www.ensembl.org/id/ENSP00000501595.1" } ] } }, { "isoform_ac": "A0A6Q8PFI2-1", "url": "", "sequence": { "sequence": "XSNPARPGGFPGANSPGPVADLYGPASQDSGVGNYISAASPQPGSGFGHGIASIPGCPGKTGRSF", "length": 65, "header": "tr|A0A6Q8PFI2-1|MSI2H_HUMAN Computationally mapped isoform of RNA-binding protein Musashi homolog 2 OS=Homo sapiens OX=9606 GN=MSI2 PE=1 SV=1 CANONICAL=Q96DH6-1" }, "locus": { "chromosome": "17", "start_pos": 57679588, "end_pos": 57674972, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000674522.1", "url": "https://www.ensembl.org/id/ENST00000674522.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000501836.1", "url": "https://www.ensembl.org/id/ENSP00000501836.1" } ] } }, { "isoform_ac": "A0A6Q8PFU8-1", "url": "", "sequence": { "sequence": "XQGTSGSANDSQHDPGKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPKVAFPRRAQPKSSLQDNLI", "length": 107, "header": "tr|A0A6Q8PFU8-1|A0A6Q8PFU8_HUMAN Computationally mapped isoform of Musashi RNA binding protein 2 OS=Homo sapiens OX=9606 GN=MSI2 PE=1 SV=1 CANONICAL=Q96DH6-1" }, "locus": { "chromosome": "17", "start_pos": 57370973, "end_pos": 57256759, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000674961.1", "url": "https://www.ensembl.org/id/ENST00000674961.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000501981.1", "url": "https://www.ensembl.org/id/ENSP00000501981.1" } ] } }, { "isoform_ac": "A0A6Q8PGD8-1", "url": "", "sequence": { "sequence": "MPGWEFCLRCWEPVTCSTQVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQFPDYLPVSQDIIFIN", "length": 139, "header": "tr|A0A6Q8PGD8-1|A0A6Q8PGD8_HUMAN Computationally mapped isoform of Musashi RNA binding protein 2 OS=Homo sapiens OX=9606 GN=MSI2 PE=1 SV=1 CANONICAL=Q96DH6-1" }, "locus": { "chromosome": "17", "start_pos": 57631828, "end_pos": 57487233, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000674898.1", "url": "https://www.ensembl.org/id/ENST00000674898.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000502212.1", "url": "https://www.ensembl.org/id/ENSP00000502212.1" } ] } }, { "isoform_ac": "A0A6Q8PGF5-1", "url": "", "sequence": { "sequence": "IDPKVAFPRRAQPKACLDLCSASVSWTENHCAAS", "length": 34, "header": "tr|A0A6Q8PGF5-1|MSI2H_HUMAN Computationally mapped isoform of RNA-binding protein Musashi homolog 2 OS=Homo sapiens OX=9606 GN=MSI2 PE=1 SV=1 CANONICAL=Q96DH6-1" }, "locus": { "chromosome": "17", "start_pos": 57310190, "end_pos": 57262151, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000675822.1", "url": "https://www.ensembl.org/id/ENST00000675822.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000502227.1", "url": "https://www.ensembl.org/id/ENSP00000502227.1" } ] } }, { "isoform_ac": "A0A6Q8PH26-1", "url": "", "sequence": { "sequence": "XFPAAAYGPVAAAAVAAARGSGSAHLLSNTLLSTLSGKAPTRRGPEASRGPTAQDLSPISTALPARTPEWGIT", "length": 73, "header": "tr|A0A6Q8PH26-1|A0A6Q8PH26_HUMAN Computationally mapped isoform of Musashi RNA binding protein 2 OS=Homo sapiens OX=9606 GN=MSI2 PE=4 SV=1 CANONICAL=Q96DH6-1" }, "locus": { "chromosome": "17", "start_pos": 57675077, "end_pos": 57652099, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000675127.1", "url": "https://www.ensembl.org/id/ENST00000675127.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000502546.1", "url": "https://www.ensembl.org/id/ENSP00000502546.1" } ] } }, { "isoform_ac": "A0A6Q8PH41-1", "url": "", "sequence": { "sequence": "XKMFIGGLSWQTSPALETILANLEKLENVWS", "length": 31, "header": "tr|A0A6Q8PH41-1|A0A6Q8PH41_HUMAN Computationally mapped isoform of Musashi RNA binding protein 2 OS=Homo sapiens OX=9606 GN=MSI2 PE=4 SV=1 CANONICAL=Q96DH6-1" }, "locus": { "chromosome": "17", "start_pos": 57257521, "end_pos": 57257098, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000676105.1", "url": "https://www.ensembl.org/id/ENST00000676105.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000502565.1", "url": "https://www.ensembl.org/id/ENSP00000502565.1" } ] } }, { "isoform_ac": "A0A6Q8PH51-1", "url": "", "sequence": { "sequence": "XFPAAAYGPVAAAAVAAARGSEHTWMSRQDWAKFLSGPLFR", "length": 41, "header": "tr|A0A6Q8PH51-1|A0A6Q8PH51_HUMAN Computationally mapped isoform of Musashi RNA binding protein 2 OS=Homo sapiens OX=9606 GN=MSI2 PE=4 SV=1 CANONICAL=Q96DH6-1" }, "locus": { "chromosome": "17", "start_pos": 57679608, "end_pos": 57652099, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000675379.1", "url": "https://www.ensembl.org/id/ENST00000675379.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000502532.1", "url": "https://www.ensembl.org/id/ENSP00000502532.1" } ] } }, { "isoform_ac": "A0A6Q8PHP1-1", "url": "", "sequence": { "sequence": "VEDAMLMFDKTTNRHRGGLAEA", "length": 22, "header": "tr|A0A6Q8PHP1-1|A0A6Q8PHP1_HUMAN Computationally mapped isoform of Musashi RNA binding protein 2 OS=Homo sapiens OX=9606 GN=MSI2 PE=1 SV=1 CANONICAL=Q96DH6-1" }, "locus": { "chromosome": "17", "start_pos": 57557006, "end_pos": 57529676, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000674574.1", "url": "https://www.ensembl.org/id/ENST00000674574.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000502773.1", "url": "https://www.ensembl.org/id/ENSP00000502773.1" } ] } }, { "isoform_ac": "A0A6Q8PHT3-1", "url": "", "sequence": { "sequence": "XKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPKVAFPRRAQPKRASQS", "length": 89, "header": "tr|A0A6Q8PHT3-1|A0A6Q8PHT3_HUMAN Computationally mapped isoform of Musashi RNA binding protein 2 OS=Homo sapiens OX=9606 GN=MSI2 PE=1 SV=1 CANONICAL=Q96DH6-1" }, "locus": { "chromosome": "17", "start_pos": 57263504, "end_pos": 57257098, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000676073.1", "url": "https://www.ensembl.org/id/ENST00000676073.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000502813.1", "url": "https://www.ensembl.org/id/ENSP00000502813.1" } ] } }, { "isoform_ac": "B4DHE8-1", "url": "", "sequence": { "sequence": "MFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQFPGFPAAAYGPVAAAAVAAARGSVLNSYSAQPNFGAPASPAGSNPARPGGFPGANSPGPVADLYGPASQDSGVGNYISAASPQPGSGFGHGIAGPLIATAFTNGYH", "length": 324, "header": "tr|B4DHE8-1|B4DHE8_HUMAN Computationally mapped isoform of cDNA FLJ56904, highly similar to RNA-binding protein Musashi homolog 2 OS=Homo sapiens OX=9606 GN=MSI2 PE=1 SV=1 CANONICAL=Q96DH6-1" }, "locus": { "chromosome": "17", "start_pos": 57677025, "end_pos": 57257102, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000416426.6", "url": "https://www.ensembl.org/id/ENST00000416426.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000414671.2", "url": "https://www.ensembl.org/id/ENSP00000414671.2" } ] } }, { "isoform_ac": "B4DM51-1", "url": "", "sequence": { "sequence": "MMRGYIKKVLKNTSYHVNQYLFIQHGWSGSGDQSVLYSCNLMRMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQFPGFPAAAYGPVAAAAVAAARGSGSNPARPGGFPGANSPGPVADLYGPASQDSGVGNYISAASPQPGSGFGHGIAGPLIATAFTNGYH", "length": 267, "header": "tr|B4DM51-1|B4DM51_HUMAN Computationally mapped isoform of cDNA FLJ52888, highly similar to RNA-binding protein Musashi homolog 2 OS=Homo sapiens OX=9606 GN=MSI2 PE=1 SV=1 CANONICAL=Q96DH6-1" }, "locus": { "chromosome": "17", "start_pos": 57677025, "end_pos": 57285884, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000442934.6", "url": "https://www.ensembl.org/id/ENST00000442934.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000392607.2", "url": "https://www.ensembl.org/id/ENSP00000392607.2" } ] } }, { "isoform_ac": "J3KTC1-1", "url": "", "sequence": { "sequence": "MADLTSVLTSVMFSPSSKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVSAGSPGLS", "length": 140, "header": "tr|J3KTC1-1|J3KTC1_HUMAN Computationally mapped isoform of Musashi RNA binding protein 2 OS=Homo sapiens OX=9606 GN=MSI2 PE=1 SV=8 CANONICAL=Q96DH6-1" }, "locus": { "chromosome": "17", "start_pos": 57432612, "end_pos": 57257048, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000579590.5", "url": "https://www.ensembl.org/id/ENST00000579590.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000462914.1", "url": "https://www.ensembl.org/id/ENSP00000462914.1" } ] } }, { "isoform_ac": "J3QKT5-1", "url": "", "sequence": { "sequence": "MEANGSQGTSGSANDSQHDPGKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTCRRQKRLVY", "length": 99, "header": "tr|J3QKT5-1|J3QKT5_HUMAN Computationally mapped isoform of Musashi RNA binding protein 2 OS=Homo sapiens OX=9606 GN=MSI2 PE=1 SV=1 CANONICAL=Q96DH6-1" }, "locus": { "chromosome": "17", "start_pos": 57260003, "end_pos": 57256743, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000581776.5", "url": "https://www.ensembl.org/id/ENST00000581776.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000463227.1", "url": "https://www.ensembl.org/id/ENSP00000463227.1" } ] } }, { "isoform_ac": "Q96DH6-1", "url": "", "sequence": { "sequence": "MEANGSQGTSGSANDSQHDPGKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQFPGFPAAAYGPVAAAAVAAARGSGSNPARPGGFPGANSPGPVADLYGPASQDSGVGNYISAASPQPGSGFGHGIAGPLIATAFTNGYH", "length": 328, "header": "sp|Q96DH6-1|MSI2H_HUMAN Isoform 1 of RNA-binding protein Musashi homolog 2 OS=Homo sapiens OX=9606 GN=MSI2 PE=1 SV=1 CANONICAL=Q96DH6-1" }, "locus": { "chromosome": "17", "start_pos": 57677025, "end_pos": 57256743, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000674964.1", "url": "https://www.ensembl.org/id/ENST00000674964.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000502137.1", "url": "https://www.ensembl.org/id/ENSP00000502137.1" } ] } }, { "isoform_ac": "Q96DH6-2", "url": "", "sequence": { "sequence": "MADLTSVLTSVMFSPSSKMFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELDSKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQFPDYLPVSQDIIFIN", "length": 251, "header": "sp|Q96DH6-2|MSI2H_HUMAN Isoform 2 of RNA-binding protein Musashi homolog 2 OS=Homo sapiens OX=9606 GN=MSI2 PE=1 SV=1 CANONICAL=Q96DH6-1" }, "locus": { "chromosome": "17", "start_pos": 57631828, "end_pos": 57257048, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000322684.7", "url": "https://www.ensembl.org/id/ENST00000322684.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000313616.3", "url": "https://www.ensembl.org/id/ENSP00000313616.3" } ] } }, { "isoform_ac": "Q96DH6-3", "url": "", "sequence": { "sequence": "MVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRGFGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVMFPPGTRGRARGLPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSYGYQFPDYLPVSQDIIFIN", "length": 151, "header": "sp|Q96DH6-3|MSI2H_HUMAN Isoform 3 of RNA-binding protein Musashi homolog 2 OS=Homo sapiens OX=9606 GN=MSI2 PE=1 SV=1 CANONICAL=Q96DH6-1" }, "locus": { "chromosome": "17", "start_pos": 57631828, "end_pos": 57401379, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000579180.2", "url": "https://www.ensembl.org/id/ENST00000579180.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000462264.1", "url": "https://www.ensembl.org/id/ENSP00000462264.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "Q96DH6", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q96DH6" }, { "id": "28510447", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28510447" }, { "id": "22121020", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22121020" } ] } ], "phosphorylation": [ { "start_pos": 146, "end_pos": 146, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q96DH6", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q96DH6" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Thr146" }, { "start_pos": 6, "end_pos": 6, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q96DH6", "url": "https://www.uniprot.org/uniprot/Q96DH6" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "Q96DH6", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q96DH6" } ], "site_lbl": "Ser6" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "A novel gene, MSI2, encoding a putative RNA-binding protein is recurrently rearranged at disease progression of chronic myeloid leukemia and forms a fusion gene with HOXA9 as a result of the cryptic t(7;17)(p15;q23).", "journal": "Cancer Res.", "date": "2003", "authors": "Barbouti A, Hoglund M, Johansson B, Lassen C, Nilsson PG, Hagemeijer A, Mitelman F, Fioretos T", "evidence": [ { "database": "UniProtKB", "id": "Q96DH6", "url": "https://www.uniprot.org/uniprot/Q96DH6" } ], "reference": [ { "type": "PubMed", "id": "12649177", "url": "https://glygen.org/publication/PubMed/12649177" } ] }, { "title": "RhoBTB2 is a substrate of the mammalian Cul3 ubiquitin ligase complex.", "journal": "Genes & development", "date": "2004", "authors": "Wilkins A, Ping Q, Carpenter CL", "evidence": [ { "database": "Reactome", "id": "R-HSA-9013418", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013418" } ], "reference": [ { "type": "PubMed", "id": "15107402", "url": "https://glygen.org/publication/PubMed/15107402" } ] }, { "title": "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.", "journal": "Mol. Cell", "date": "2008", "authors": "Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Korner R, Greff Z, Keri G, Stemmann O, Mann M", "evidence": [ { "database": "UniProtKB", "id": "Q96DH6", "url": "https://www.uniprot.org/uniprot/Q96DH6" }, { "database": "UniProtKB", "id": "J3KTC1", "url": "https://www.uniprot.org/uniprot/J3KTC1" } ], "reference": [ { "type": "PubMed", "id": "18691976", "url": "https://glygen.org/publication/PubMed/18691976" } ] }, { "title": "EVI1 overexpression in t(3;17) positive myeloid malignancies results from juxtaposition of EVI1 to the MSI2 locus at 17q22.", "journal": "Haematologica", "date": "2008", "authors": "De Weer A, Speleman F, Cauwelier B, Van Roy N, Yigit N, Verhasselt B, De Moerloose B, Benoit Y, Noens L, Selleslag D, Lippert E, Struski S, Bastard C, De Paepe A, Vandenberghe P, Hagemeijer A, Dastugue N, Poppe B", "evidence": [ { "database": "RefSeq", "id": "NP_001309179", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001309179" }, { "database": "RefSeq", "id": "NP_620412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620412" } ], "reference": [ { "type": "PubMed", "id": "18815193", "url": "https://glygen.org/publication/PubMed/18815193" } ] }, { "title": "Characterization of RhoBTB-dependent Cul3 ubiquitin ligase complexes--evidence for an autoregulatory mechanism.", "journal": "Experimental cell research", "date": "2008", "authors": "Berthold J, Schenkova K, Ramos S, Miura Y, Furukawa M, Aspenstrom P, Rivero F", "evidence": [ { "database": "Reactome", "id": "R-HSA-9013418", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013418" } ], "reference": [ { "type": "PubMed", "id": "18835386", "url": "https://glygen.org/publication/PubMed/18835386" } ] }, { "title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.", "journal": "Science signaling", "date": "2010", "authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M", "evidence": [ { "database": "iPTMnet", "id": "Q96DH6-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q96DH6-1" } ], "reference": [ { "type": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ] }, { "title": "Regulation of myeloid leukaemia by the cell-fate determinant Musashi.", "journal": "Nature", "date": "2010", "authors": "Ito T, Kwon HY, Zimdahl B, Congdon KL, Blum J, Lento WE, Zhao C, Lagoo A, Gerrard G, Foroni L, Goldman J, Goh H, Kim SH, Kim DW, Chuah C, Oehler VG, Radich JP, Jordan CT, Reya T", "evidence": [ { "database": "RefSeq", "id": "NP_620412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620412" }, { "database": "RefSeq", "id": "NP_001309179", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001309179" } ], "reference": [ { "type": "PubMed", "id": "20639863", "url": "https://glygen.org/publication/PubMed/20639863" } ] }, { "title": "A cancer fate in the hands of a samurai.", "journal": "Nature medicine", "date": "2010", "authors": "Moore MA", "evidence": [ { "database": "RefSeq", "id": "NP_001309179", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001309179" }, { "database": "RefSeq", "id": "NP_620412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620412" } ], "reference": [ { "type": "PubMed", "id": "20823875", "url": "https://glygen.org/publication/PubMed/20823875" } ] }, { "title": "GlcNAcylation of histone H2B facilitates its monoubiquitination.", "journal": "Nature", "date": "2011", "authors": "Fujiki R, Hashiba W, Sekine H, Yokoyama A, Chikanishi T, Ito S, Imai Y, Kim J, He HH, Igarashi K, Kanno J, Ohtake F, Kitagawa H, Roeder RG, Brown M, Kato S", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q96DH6", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q96DH6" } ], "reference": [ { "type": "PubMed", "id": "22121020", "url": "https://glygen.org/publication/PubMed/22121020" } ] }, { "title": "Toward a comprehensive characterization of a human cancer cell phosphoproteome.", "journal": "Journal of proteome research", "date": "2013", "authors": "Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S", "evidence": [ { "database": "UniProtKB", "id": "Q96DH6", "url": "https://www.uniprot.org/uniprot/Q96DH6" }, { "database": "iPTMnet", "id": "Q96DH6", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q96DH6" } ], "reference": [ { "type": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" } ] }, { "title": "Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.", "journal": "Mol. Cell. Proteomics", "date": "2014", "authors": "Guo A, Gu H, Zhou J, Mulhern D, Wang Y, Lee KA, Yang V, Aguiar M, Kornhauser J, Jia X, Ren J, Beausoleil SA, Silva JC, Vemulapalli V, Bedford MT, Comb MJ", "evidence": [ { "database": "UniProtKB", "id": "Q96DH6", "url": "https://www.uniprot.org/uniprot/Q96DH6" }, { "database": "UniProtKB", "id": "B4DM51", "url": "https://www.uniprot.org/uniprot/B4DM51" }, { "database": "UniProtKB", "id": "B4DHE8", "url": "https://www.uniprot.org/uniprot/B4DHE8" } ], "reference": [ { "type": "PubMed", "id": "24129315", "url": "https://glygen.org/publication/PubMed/24129315" } ] }, { "title": "Hsp90-dependent assembly of the DBC2/RhoBTB2-Cullin3 E3-ligase complex.", "journal": "PloS one", "date": "2014", "authors": "Manjarrez JR, Sun L, Prince T, Matts RL", "evidence": [ { "database": "Reactome", "id": "R-HSA-9013418", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013418" } ], "reference": [ { "type": "PubMed", "id": "24608665", "url": "https://glygen.org/publication/PubMed/24608665" } ] }, { "title": "DBC2/RhoBTB2 functions as a tumor suppressor protein via Musashi-2 ubiquitination in breast cancer.", "journal": "Oncogene", "date": "2017", "authors": "Choi YM, Kim KB, Lee JH, Chun YK, An IS, An S, Bae S", "evidence": [ { "database": "Reactome", "id": "R-HSA-9013418", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013418" } ], "reference": [ { "type": "PubMed", "id": "27941885", "url": "https://glygen.org/publication/PubMed/27941885" } ] }, { "title": "Synthesis of a Highly Azide-Reactive and Thermosensitive Biofunctional Reagent for Efficient Enrichment and Large-Scale Identification of O-GlcNAc Proteins by Mass Spectrometry.", "journal": "Analytical chemistry", "date": "2017", "authors": "Zhang W, Liu T, Dong H, Bai H, Tian F, Shi Z, Chen M, Wang J, Qin W, Qian X", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q96DH6", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q96DH6" } ], "reference": [ { "type": "PubMed", "id": "28510447", "url": "https://glygen.org/publication/PubMed/28510447" } ] }, { "title": "Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms.", "journal": "Nature cell biology", "date": "2020", "authors": "Bagci H, Sriskandarajah N, Robert A, Boulais J, Elkholi IE, Tran V, Lin ZY, Thibault MP, Dube N, Faubert D, Hipfner DR, Gingras AC, Cote JF", "evidence": [ { "database": "Reactome", "id": "R-HSA-9013418", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013418" } ], "reference": [ { "type": "PubMed", "id": "31871319", "url": "https://glygen.org/publication/PubMed/31871319" } ] }, { "title": "Theoretical studies on RNA recognition by Musashi 1 RNA-binding protein.", "journal": "Scientific reports", "date": "2022", "authors": "Darai N, Mahalapbutr P, Wolschann P, Lee VS, Wolfinger MT, Rungrotmongkol T", "evidence": [ { "database": "RefSeq", "id": "NP_001309179", "url": 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