{ "uniprot_canonical_ac": "Q96DA0-1", "uniprot_ac": "Q96DA0", "uniprot_id": "ZG16B_HUMAN", "mass": { "chemical_mass": 22739.0, "monoisotopic_mass": 22739.0 }, "refseq": { "ac": "NP_660295", "name": "zymogen granule protein 16 homolog B precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_660295" }, "gene_names": [ { "name": "ZG16B", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q96DA0", "id": "Q96DA0" }, { "name": "EECP; HRPE773; JCLN2; PAUF; PRO1567", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_660295", "id": "NP_660295" }, { "name": "PRO1567", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q96DA0", "id": "Q96DA0" }, { "name": "ZG16B", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_660295", "id": "NP_660295" } ], "protein_names": [ { "name": "Zymogen granule protein 16 homolog B", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q96DA0" }, { "name": "jacalin-like lectin domain containing 2; pancreatic adenocarcinoma upregulated factor; endocrine and exocrine protein; zymogen granule protein 16 homolog B", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_660295", "id": "NP_660295" }, { "name": "zymogen granule protein 16 homolog B precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_660295", "id": "NP_660295" } ], "function": [ { "annotation": "Bioinformatic analysis identified a putative human CSP-1/Dcpp ortholog, HRPE773, expressed predominantly in human salivary tissue, that shows 31% amino acid identity and 45% amino acid similarity to the mouse Dcpp query sequence.", "evidence": [ { "database": "RefSeq", "id": "NP_660295", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_660295" }, { "database": "PubMed", "id": "16954406", "url": "https://glygen.org/publication/PubMed/16954406" } ] }, { "annotation": "Human oral lectin ZG16B acts as a cell wall polysaccharide probe to decode host-microbe interactions with oral commensals.", "evidence": [ { "database": "RefSeq", "id": "NP_660295", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_660295" }, { "database": "PubMed", "id": "37216558", "url": "https://glygen.org/publication/PubMed/37216558" } ] }, { "annotation": "PAUF Induces Migration of Human Pancreatic Cancer Cells Exclusively via the TLR4/MyD88/NF-kappaB Signaling Pathway. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_660295", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_660295" }, { "database": "PubMed", "id": "36232715", "url": "https://glygen.org/publication/PubMed/36232715" } ] }, { "annotation": "PAUF/ZG16B promotes colorectal cancer progression through alterations of the mitotic functions and the Wnt/beta-catenin pathway.", "evidence": [ { "database": "RefSeq", "id": "NP_660295", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_660295" }, { "database": "PubMed", "id": "31095674", "url": "https://glygen.org/publication/PubMed/31095674" } ] }, { "annotation": "Pancreatic cancer induces muscle wasting by promoting the release of pancreatic adenocarcinoma upregulated factor.", "evidence": [ { "database": "RefSeq", "id": "NP_660295", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_660295" }, { "database": "PubMed", "id": "33731895", "url": "https://glygen.org/publication/PubMed/33731895" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "56.13", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000162078", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000162078" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "80.77", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000162078", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000162078" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "89.57", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000162078", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000162078" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "69", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000162078", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000162078" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "92.7", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000162078", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000162078" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "70.18", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000162078", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000162078" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "56.68", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000162078", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000162078" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "43.84", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000162078", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000162078" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "97.23", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000162078", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000162078" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "81.04", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000162078", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000162078" } ] } ], "expression_disease": [ { "significant": "No", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "Q96DA0", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q96DA0" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, 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{ "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q96DA0" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { 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"MLLLLTLALLGGPTWAGKMYGPGGGKYFSTTEDYDHEITGLRVSVGLLLVKR", "length": 52, "header": "tr|I3L1H9-1|ZG16B_HUMAN Computationally mapped isoform of Zymogen granule protein 16 homolog B OS=Homo sapiens OX=9606 GN=ZG16B PE=1 SV=2 CANONICAL=Q96DA0-1" }, "locus": { "chromosome": "16", "start_pos": 2830797, "end_pos": 2830442, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000571723.2", "url": "https://www.ensembl.org/id/ENST00000571723.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000458847.2", "url": "https://www.ensembl.org/id/ENSP00000458847.2" } ] } }, { "isoform_ac": "I3L3X0-1", "url": "", "sequence": { "sequence": "MLLLLTLALLGGPTWAGKMYGPGGGKYFSTTEDYDHEITGLRVSVGLLLVKRFLEGVIYE", "length": 60, "header": "tr|I3L3X0-1|I3L3X0_HUMAN Computationally mapped isoform of Zymogen granule protein 16B OS=Homo sapiens OX=9606 GN=ZG16B PE=4 SV=2 CANONICAL=Q96DA0-1" }, "locus": { "chromosome": "16", "start_pos": 2838400, "end_pos": 2830442, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000570670.6", "url": "https://www.ensembl.org/id/ENST00000570670.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000460793.2", "url": "https://www.ensembl.org/id/ENSP00000460793.2" } ] } }, { "isoform_ac": "Q96DA0-1", "url": "", "sequence": { "sequence": "MGAQGAQESIKAMWRVPGTTRRPVTGESPGMHRPEAMLLLLTLALLGGPTWAGKMYGPGGGKYFSTTEDYDHEITGLRVSVGLLLVKSVQVKLGDSWDVKLGALGGNTQEVTLQPGEYITKVFVAFQAFLRGMVMYTSKDRYFYFGKLDGQISSAYPSQEGQVLVGIYGQYQLLGIKSIGFEWNYPLEEPTTEPPVNLTYSANSPVGR", "length": 208, "header": "sp|Q96DA0-1|ZG16B_HUMAN Isoform 1 of Zymogen granule protein 16 homolog B OS=Homo sapiens OX=9606 GN=ZG16B PE=1 SV=3 CANONICAL=Q96DA0-1" }, "locus": { "chromosome": "16", "start_pos": 2832156, "end_pos": 2830442, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000382280.8", "url": "https://www.ensembl.org/id/ENST00000382280.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000371715.4", "url": "https://www.ensembl.org/id/ENSP00000371715.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G39188ZX", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 197, "start_aa": "Asn", "end_pos": 197, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn197", "evidence": [ { "id": "1909", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/1909" }, { "id": "29741879", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29741879" } ] }, { "glytoucan_ac": "G39619TI", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 197, "start_aa": "Asn", "end_pos": 197, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn197", "evidence": [ { "id": "1909", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/1909" }, { "id": "29741879", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29741879" } ] }, { "glytoucan_ac": "G46524LG", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 197, "start_aa": "Asn", "end_pos": 197, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn197", "evidence": [ { "id": "1909", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/1909" }, { "id": "29741879", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29741879" } ] }, { "glytoucan_ac": "G50757KG", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 197, "start_aa": "Asn", "end_pos": 197, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn197", "evidence": [ { "id": "1909", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/1909" }, { "id": "29741879", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29741879" } ] }, { "glytoucan_ac": "G70101JE", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 197, "start_aa": "Asn", "end_pos": 197, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn197", "evidence": [ { "id": "1909", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/1909" }, { "id": "29741879", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29741879" } ] }, { "glytoucan_ac": "G96416FQ", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 197, "start_aa": "Asn", "end_pos": 197, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn197", "evidence": [ { "id": "1909", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/1909" }, { "id": "29741879", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29741879" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 197, "start_aa": "Asn", "end_pos": 197, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn197", "evidence": [ { "id": "Q96DA0", "database": "UniCarbKB", "url": "" }, { "id": "29741879", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29741879" }, { "id": "Q96DA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96DA0#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Mass spectrometry allows direct identification of proteins in large genomes.", "journal": "Proteomics", "date": "2001", "authors": "Kuster B, Mortensen P, Andersen JS, Mann M", "evidence": [ { "database": "UniProtKB", "id": "Q96DA0", "url": "https://www.uniprot.org/uniprot/Q96DA0" } ], "reference": [ { "type": "PubMed", "id": "11678034", "url": "https://glygen.org/publication/PubMed/11678034" } ] }, { "title": "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.", "journal": "Genome Res.", "date": "2003", "authors": "Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A", "evidence": [ { "database": "UniProtKB", "id": "Q96DA0", "url": "https://www.uniprot.org/uniprot/Q96DA0" } ], "reference": [ { "type": "PubMed", "id": "12975309", "url": "https://glygen.org/publication/PubMed/12975309" } ] }, { "title": "Identification of a human ortholog of the mouse Dcpp gene locus, encoding a novel member of the CSP-1/Dcpp salivary protein family.", "journal": "Physiological genomics", "date": "2006", "authors": "Mullins JJ, Mullins LJ, Dunbar DR, Brammar WJ, Gross KW, Morley SD", "evidence": [ { "database": "RefSeq", "id": "NP_660295", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_660295" } ], "reference": [ { "type": "PubMed", "id": "16954406", "url": "https://glygen.org/publication/PubMed/16954406" } ] }, { "title": "Crystal structures of human secretory proteins ZG16p and ZG16b reveal a Jacalin-related beta-prism fold.", "journal": "Biochem. Biophys. Res. Commun.", "date": "2011", "authors": "Kanagawa M, Satoh T, Ikeda A, Nakano Y, Yagi H, Kato K, Kojima-Aikawa K, Yamaguchi Y", "evidence": [ { "database": "UniProtKB", "id": "Q96DA0", "url": "https://www.uniprot.org/uniprot/Q96DA0" } ], "reference": [ { "type": "PubMed", "id": "21110947", "url": "https://glygen.org/publication/PubMed/21110947" } ] }, { "title": "Reanalysis of Global Proteomic and Phosphoproteomic Data Identified a Large Number of Glycopeptides.", "journal": "Analytical chemistry", "date": "2018", "authors": "Hu Y, Shah P, Clark DJ, Ao M, Zhang H", "evidence": [ { "database": "UniCarbKB", "id": "Q96DA0", "url": "" }, { "database": "GlyConnect", "id": "1909", "url": "https://glyconnect.expasy.org/browser/proteins/1909" } ], "reference": [ { "type": "PubMed", "id": "29741879", "url": "https://glygen.org/publication/PubMed/29741879" } ] }, { "title": "PAUF/ZG16B promotes colorectal cancer progression through alterations of the mitotic functions and the Wnt/beta-catenin pathway.", "journal": "Carcinogenesis", "date": "2020", "authors": "Escudero-Paniagua B, Bartolome RA, Rodriguez S, De Los Rios V, Pintado L, Jaen M, Lafarga M, Fernandez-Acenero MJ, Casal JI", "evidence": [ { "database": "RefSeq", "id": "NP_660295", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_660295" } ], "reference": [ { "type": "PubMed", "id": "31095674", "url": "https://glygen.org/publication/PubMed/31095674" } ] }, { "title": "Pancreatic cancer induces muscle wasting by promoting the release of pancreatic adenocarcinoma upregulated factor.", "journal": "Experimental & molecular medicine", "date": "2021", "authors": "Yoo W, Choi H, Son YH, Lee J, Jo S, Jung D, Kim YJ, Koh SS, Yang YR, Kwon ES, Lee KP, Noh KH, Kim KW, Ko Y, Jun E, Kim SC, Kim S", "evidence": [ { "database": "RefSeq", "id": "NP_660295", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_660295" } ], "reference": [ { "type": "PubMed", "id": "33731895", "url": "https://glygen.org/publication/PubMed/33731895" } ] }, { "title": "PAUF Induces Migration of Human Pancreatic Cancer Cells Exclusively via the TLR4/MyD88/NF-\u03baB Signaling Pathway.", "journal": "International journal of molecular sciences", "date": "2022-09-27", "authors": "Youn So Eun, Jiang Fen, Won Hye Yun, Hong Da Eun, Kang Tae Heung, Park Yun-Yong, Koh Sang Seok", "evidence": [ { "database": "RefSeq", "id": "NP_660295", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_660295" } ], "reference": [ { "type": "PubMed", "id": "36232715", "url": "https://glygen.org/publication/PubMed/36232715" } ] }, { "title": "Human oral lectin ZG16B acts as a cell wall polysaccharide probe to decode host-microbe interactions with oral commensals.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2023-05-30", "authors": "Ghosh Soumi, Ahearn Christian P, Isabella Christine R, Marando Victoria M, Dodge Gregory J, Bartlett Helen, McPherson Robert L, Dugan Amanda E, Jain Shikha, Neznanova Lubov, Tettelin Herv\u00e9, Putnik Rachel, Grimes Catherine L, Ruhl Stefan, Kiessling Laura L, Imperiali Barbara", "evidence": [ { "database": "RefSeq", "id": "NP_660295", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_660295" } ], "reference": [ { "type": "PubMed", "id": "37216558", "url": "https://glygen.org/publication/PubMed/37216558" } ] } ], "pathway": [ { "id": "hsa:124220", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:124220", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "P08723-1", "protein_name": "Prostatic spermine-binding protein", "gene_name": "Sbp", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MLLLVTLALLAGPTCRAQNILGNNVGTYFYVAGEEHGQLRGIRIFLTVIDLIKGIQLRFGGNWSDVYGSRSLKYKEFLLEDGEHVTQVSGTRKLCLTSLSFTTNKGRVVTFGVRRGLSFNESGGSDKYLVTVNGLYAPGLCLNGMGFKWKNIHDDFDDNDDDKEDDDDEHDDDNEEDHGDKDNDNDHDDDHDDDDDDKEDDNEEDVDDERDDKDDDEEDDDNDKENDKDDGEGSGDDDDNDDEDDDKDDDGGSGDDGDDGDDDEDDDGGDDDNGDEEEE", "length": 279 }, "evidence": [ { "id": "45244372", "url": "http://www.informatics.jax.org/homology/45244372", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "P15501-1", "protein_name": "Prostatic spermine-binding protein", "gene_name": "Sbp", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MLLLLTLAFLASPTCRAQNVLGNAAGKYFYVQGEDQGQLKGMRIFLSVFKFIKGFQLQFGSNWTDVYGTRSDNFIDFLLEDGEHVIKVEGSAVICLTSLTFTTNKGRVATFGVRRGRYFSDTGGSDKHLVTVNGMHAPGLCVRGIGFKWGNINANGNDHYNNKEDKADNKDADNKDADNKDDGDEDDDGNDDDDQKDES", "length": 199 }, "evidence": [ { "id": "45244372", "url": "http://www.informatics.jax.org/homology/45244372", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q3TUY3-1", "protein_name": "Spermine binding protein-like", "gene_name": "Sbpl", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": 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"total": 1, "go_terms": [ { "name": "retina homeostasis", "id": "GO:0001895", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001895", "evidence": [ { "database": "UniProtKB", "id": "Q96DA0", "url": "https://www.uniprot.org/uniprot/Q96DA0" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "carbohydrate binding", "id": "GO:0030246", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030246", "evidence": [ { "database": "UniProtKB", "id": "Q96DA0", "url": "https://www.uniprot.org/uniprot/Q96DA0" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 197, "end_pos": 199, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { 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"table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 6 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 6 }, { "field": "n_linked_glycan_sites", "count": 1 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 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