{ "uniprot_canonical_ac": "Q96C90-1", "uniprot_ac": "Q96C90", "uniprot_id": "PP14B_HUMAN", "mass": { "chemical_mass": 15911.0, "monoisotopic_mass": 15911.0 }, "refseq": { "ac": "NP_619634", "name": "protein phosphatase 1 regulatory subunit 14B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_619634" }, "gene_names": [ { "name": "PPP1R14B", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q96C90", "id": "Q96C90" }, { "name": "PHI-1; PLCB3N; PNG; SOM172", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_619634", "id": "NP_619634" }, { "name": "PLCB3N", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q96C90", "id": "Q96C90" }, { "name": "PNG", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q96C90", "id": "Q96C90" }, { "name": "PPP1R14B", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_619634", "id": "NP_619634" } ], "protein_names": [ { "name": "Protein phosphatase 1 regulatory subunit 14B", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q96C90" }, { "name": "Phospholipase C-beta-3 neighbouring gene protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q96C90" }, { "name": "phospholipase C beta-3 neighboring gene protein; phospholipase C-beta-3 neighbouring gene protein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_619634", "id": "NP_619634" }, { "name": "protein phosphatase 1 regulatory subunit 14B", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_619634", "id": "NP_619634" } ], "function": [ { "annotation": "An inhibitory phosphoprotein that inhibits the myosin- and glycogen-associated holoenzyme versions of protein type-1 phosphatase (PP1) as well as the monomeric catalytic subunit of PP1 in multiple tissues.", "evidence": [ { "database": "RefSeq", "id": "NP_619634", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_619634" }, { "database": "PubMed", "id": "10606530", "url": "https://glygen.org/publication/PubMed/10606530" } ] }, { "annotation": "In vitro assessment of roles of PPP1R14B in cervical and endometrial cancer.", "evidence": [ { "database": "RefSeq", "id": "NP_619634", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_619634" }, { "database": "PubMed", "id": "35679681", "url": "https://glygen.org/publication/PubMed/35679681" } ] }, { "annotation": "Inhibitor of PPP1CA.", "evidence": [ { "database": "UniProtKB", "id": "F5H2U0", "url": "https://www.uniprot.org/uniprot/F5H2U0#function" }, { "database": "UniProtKB", "id": "RU369059", "url": "https://www.uniprot.org/uniprot/RU369059#function" }, { "database": "UniProtKB", "id": "F5GXC4", "url": "https://www.uniprot.org/uniprot/F5GXC4#function" } ] }, { "annotation": "Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q96C90", "url": "https://www.uniprot.org/uniprot/Q96C90#function" } ] }, { "annotation": "Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)", "evidence": [ { "database": "RefSeq", "id": "NP_619634", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_619634" }, { "database": "PubMed", "id": "20628086", "url": "https://glygen.org/publication/PubMed/20628086" } ] }, { "annotation": "Observational study of gene-disease association. (HuGE Navigator)", "evidence": [ { "database": "RefSeq", "id": "NP_619634", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_619634" }, { "database": "PubMed", "id": "19913121", "url": "https://glygen.org/publication/PubMed/19913121" } ] }, { "annotation": "PHI-1 participates in regulatory events at the trailing edge of migrating cells and modulates retraction of endothelial and epithelial cells", "evidence": [ { "database": "RefSeq", "id": "NP_619634", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_619634" }, { "database": "PubMed", "id": "15522888", "url": "https://glygen.org/publication/PubMed/15522888" } ] }, { "annotation": "Protein Phosphatase 1 Subunit PPP1R14B Stabilizes STMN1 to Promote Progression and Paclitaxel Resistance in Triple-Negative Breast Cancer.", "evidence": [ { "database": "RefSeq", "id": "NP_619634", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_619634" }, { "database": "PubMed", "id": "36484700", "url": "https://glygen.org/publication/PubMed/36484700" } ] }, { "annotation": "Whereas CPI-17 staining was diffuse, PHI-1 was concentrated along the cell membrane in distinct foci. The common tissue distribution but different cellular localization of PHI-1 and CPI-17 suggest distinctive physiological roles for these PP1 inhibitors.", "evidence": [ { "database": "RefSeq", "id": "NP_619634", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_619634" }, { "database": "PubMed", "id": "15083373", "url": "https://glygen.org/publication/PubMed/15083373" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "97.52", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000173457", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000173457" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "94.53", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000173457", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000173457" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "91.12", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000173457", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000173457" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "90.29", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000173457", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000173457" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "94.05", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000173457", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000173457" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "92.58", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000173457", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000173457" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "91.47", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000173457", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000173457" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "91.74", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000173457", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000173457" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "93.2", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000173457", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000173457" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "Q96C90", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q96C90" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL 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"name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", 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"http://research.bioinformatics.udel.edu/iptmnet/entry/Q96C90" } ], "site_lbl": "Ser21" }, { "start_pos": 29, "end_pos": 29, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q96C90", "url": "https://www.uniprot.org/uniprot/Q96C90" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "Q96C90", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q96C90" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "phospho.ELM", "id": "Q96C90", "url": "http://phospho.elm.eu.org/byAccession/Q96C90.html" } ], "site_lbl": "Tyr29" }, { "start_pos": 32, "end_pos": 32, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q96C90", "url": "https://www.uniprot.org/uniprot/Q96C90" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "PubMed", "id": "16964243", "url": "https://glygen.org/publication/PubMed/16964243" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "Q96C90", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q96C90" }, { "database": "PubMed", "id": "19415658", "url": "https://glygen.org/publication/PubMed/19415658" }, { "database": "phospho.ELM", "id": "Q96C90", "url": "http://phospho.elm.eu.org/byAccession/Q96C90.html" } ], "site_lbl": "Ser32" }, { "start_pos": 4, "end_pos": 4, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q96C90", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q96C90" }, { "database": "PubMed", "id": "18491316", "url": "https://glygen.org/publication/PubMed/18491316" } ], "site_lbl": "Ser4" }, { "start_pos": 57, "end_pos": 57, "kinase_uniprot_canonical_ac": "Q13418-1", "kinase_gene_name": "ILK", "residue": "Thr", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "Q96C90", "url": "http://phospho.elm.eu.org/byAccession/Q96C90.html" }, { "database": "iPTMnet", "id": "Q96C90", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q96C90" }, { "database": "PubMed", "id": "12030846", "url": "https://glygen.org/publication/PubMed/12030846" } ], "site_lbl": "Thr57" }, { "start_pos": 57, "end_pos": 57, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q96C90", "url": "https://www.uniprot.org/uniprot/Q96C90" }, { "database": "iPTMnet", "id": "Q96C90", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q96C90" }, { "database": "PubMed", "id": "18212344", "url": "https://glygen.org/publication/PubMed/18212344" }, { "database": "PubMed", "id": "10606530", "url": "https://glygen.org/publication/PubMed/10606530" } ], "site_lbl": "Thr57" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "A novel phosphoprotein inhibitor of protein type-1 phosphatase holoenzymes.", "journal": "Biochemistry", "date": "1999", "authors": "Eto M, Karginov A, Brautigan DL", "evidence": [ { "database": "RefSeq", "id": "NP_619634", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_619634" }, { "database": "iPTMnet", "id": "Q96C90", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q96C90" } ], "reference": [ { "type": "PubMed", "id": "10606530", "url": "https://glygen.org/publication/PubMed/10606530" } ] }, { "title": "Phosphorylation of the myosin phosphatase target subunit by integrin-linked kinase.", "journal": "The Biochemical journal", "date": "2002", "authors": "Muranyi A, MacDonald JA, Deng JT, Wilson DP, Haystead TA, Walsh MP, Erdodi F, Kiss E, Wu Y, Hartshorne DJ", "evidence": [ { "database": "iPTMnet", "id": "Q96C90", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q96C90" } ], "reference": [ { "type": "PubMed", "id": "12030846", "url": "https://glygen.org/publication/PubMed/12030846" } ] }, { "title": "Juxtamembrane localization of the protein phosphatase-1 inhibitor protein PHI-1 in smooth muscle cells.", "journal": "Histochemistry and cell biology", "date": "2004", "authors": "Tountas NA, Mandell JW, Everett AD, Brautigan DL", "evidence": [ { "database": "RefSeq", "id": "NP_619634", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_619634" } ], "reference": [ { "type": "PubMed", "id": "15083373", "url": "https://glygen.org/publication/PubMed/15083373" } ] }, { "title": "Migration and retraction of endothelial and epithelial cells require PHI-1, a specific protein-phosphatase-1 inhibitor protein.", "journal": "Journal of cell science", "date": "2004", "authors": "Tountas NA, Brautigan DL", "evidence": [ { "database": "RefSeq", "id": "NP_619634", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_619634" } ], "reference": [ { "type": "PubMed", "id": "15522888", "url": "https://glygen.org/publication/PubMed/15522888" } ] }, { "title": "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.", "journal": "Nature biotechnology", "date": "2006", "authors": "Beausoleil SA, Villen J, Gerber SA, Rush J, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "Q96C90", "url": "https://www.uniprot.org/uniprot/Q96C90" }, { "database": "iPTMnet", "id": "Q96C90", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q96C90" } ], "reference": [ { "type": "PubMed", "id": "16964243", "url": "https://glygen.org/publication/PubMed/16964243" } ] }, { "title": "Hydrophilic interaction chromatography reduces the complexity of the phosphoproteome and improves global phosphopeptide isolation and detection.", "journal": "Molecular & cellular proteomics : MCP", "date": "2008", "authors": "McNulty DE, Annan RS", "evidence": [ { "database": "iPTMnet", "id": "Q96C90", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q96C90" } ], "reference": [ { "type": "PubMed", "id": "18212344", "url": "https://glygen.org/publication/PubMed/18212344" } ] }, { "title": "Phosphoproteome analysis of the human Chang liver cells using SCX and a complementary mass spectrometric strategy.", "journal": "Proteomics", "date": "2008", "authors": "Sui S, Wang J, Yang B, Song L, Zhang J, Chen M, Liu J, Lu Z, Cai Y, Chen S, Bi W, Zhu Y, He F, Qian X", "evidence": [ { "database": "iPTMnet", "id": "Q96C90", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q96C90" } ], "reference": [ { "type": "PubMed", "id": "18491316", "url": "https://glygen.org/publication/PubMed/18491316" } ] }, { "title": "A quantitative atlas of mitotic phosphorylation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2008", "authors": "Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "Q96C90", "url": "https://www.uniprot.org/uniprot/Q96C90" }, { "database": "iPTMnet", "id": "Q96C90", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q96C90" } ], "reference": [ { "type": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ] }, { "title": "Phosphoproteomic analysis of distinct tumor cell lines in response to nocodazole treatment.", "journal": "Proteomics", "date": "2009", "authors": "Nagano K, Shinkawa T, Mutoh H, Kondoh O, Morimoto S, Inomata N, Ashihara M, Ishii N, Aoki Y, Haramura M", "evidence": [ { "database": "iPTMnet", "id": "Q96C90", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q96C90" } ], "reference": [ { "type": "PubMed", "id": "19415658", "url": "https://glygen.org/publication/PubMed/19415658" } ] }, { "title": "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.", "journal": "American journal of human genetics", "date": "2009", "authors": "Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD", "evidence": [ { "database": "RefSeq", "id": "NP_619634", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_619634" } ], "reference": [ { "type": "PubMed", "id": "19913121", "url": "https://glygen.org/publication/PubMed/19913121" } ] }, { "title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.", "journal": "Science signaling", "date": "2010", "authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M", "evidence": [ { "database": "UniProtKB", "id": "Q96C90", "url": "https://www.uniprot.org/uniprot/Q96C90" }, { "database": "iPTMnet", "id": "Q96C90", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q96C90" } ], "reference": [ { "type": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ] }, { "title": "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.", "journal": "Diabetes care", "date": "2010", "authors": "Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S", "evidence": [ { "database": "RefSeq", "id": "NP_619634", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_619634" } ], "reference": [ { "type": "PubMed", "id": "20628086", "url": "https://glygen.org/publication/PubMed/20628086" } ] }, { "title": "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.", "journal": "Mol. Cell. Proteomics", "date": "2012", "authors": "Bienvenut WV, Sumpton D, Martinez A, Lilla S, Espagne C, Meinnel T, Giglione C", "evidence": [ { "database": "UniProtKB", "id": "Q96C90", "url": "https://www.uniprot.org/uniprot/Q96C90" } ], "reference": [ { "type": "PubMed", "id": "22223895", "url": "https://glygen.org/publication/PubMed/22223895" } ] }, { "title": "Toward a comprehensive characterization of a human cancer cell phosphoproteome.", "journal": "Journal of proteome research", "date": "2013", "authors": "Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S", "evidence": [ { "database": "UniProtKB", "id": "Q96C90", "url": "https://www.uniprot.org/uniprot/Q96C90" }, { "database": "iPTMnet", "id": "Q96C90", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q96C90" } ], "reference": [ { "type": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" } ] }, { "title": "Proteome wide purification and identification of O-GlcNAc-modified proteins using click chemistry and mass spectrometry.", "journal": "Journal of proteome research", "date": "2013", "authors": "Hahne H, Sobotzki N, Nyberg T, Helm D, Borodkin VS, van Aalten DM, Agnew B, Kuster B", "evidence": [ { "database": "O-GlcNAc Database", "id": "Q96C90", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q96C90" } ], "reference": [ { "type": "PubMed", "id": "23301498", "url": "https://glygen.org/publication/PubMed/23301498" } ] }, { "title": "In vitro assessment of roles of PPP1R14B in cervical and endometrial cancer.", "journal": "Tissue & cell", "date": "2022", "authors": "Xiang N, Chen T, Zhao X, Zhao M", "evidence": [ { "database": "RefSeq", "id": "NP_619634", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_619634" } ], "reference": [ { "type": "PubMed", "id": "35679681", "url": "https://glygen.org/publication/PubMed/35679681" } ] }, { "title": "Protein phosphatase 1 subunit PPP1R14B stabilizes STMN1 to promote progression and paclitaxel resistance in triple-negative breast cancer.", "journal": "Cancer research", "date": "2022-12-09", "authors": "Liao Li, Zhang Yin-Ling, Deng Ling, Chen Chao, Ma Xiao-Yan, Andriani Lisa, Yang Shao-Ying, Hu Shu-Yuan, Zhang Fang-Lin, Shao Zhi-Ming, Li Da-Qiang", "evidence": [ { "database": "RefSeq", "id": "NP_619634", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_619634" } ], "reference": [ { "type": "PubMed", "id": "36484700", "url": "https://glygen.org/publication/PubMed/36484700" } ] }, { "title": "Isolation and characterization of a novel gene close to the human phosphoinositide-specific phospholipase C beta 3 gene on chromosomal region 11q13.", "journal": "Genomics", "date": "1996", "authors": "Lagercrantz J, Carson E, Larsson C, Nordenskjold M, Weber G", "evidence": [ { "database": "UniProtKB", "id": "Q96C90", "url": "https://www.uniprot.org/uniprot/Q96C90" } ], "reference": [ { "type": "PubMed", "id": "8838322", "url": "https://glygen.org/publication/PubMed/8838322" } 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