{ "uniprot_canonical_ac": "Q969F2-1", "uniprot_ac": "Q969F2", "uniprot_id": "NKD2_HUMAN", "mass": { "chemical_mass": 50055.0, "monoisotopic_mass": 50055.0 }, "refseq": { "ac": "NP_001258011", "name": "protein naked cuticle homolog 2 isoform 2", "summary": "This gene encodes a member of a family of proteins that function as negative regulators of Wnt receptor signaling through interaction with Dishevelled family members. The encoded protein participates in the delivery of transforming growth factor alpha-containing vesicles to the cell membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258011" }, "gene_names": [ { "name": "NKD2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q969F2", "id": "Q969F2" }, { "name": "NKD2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258011", "id": "NP_001258011" }, { "name": "Naked2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258011", "id": "NP_001258011" } ], "protein_names": [ { "name": "Protein naked cuticle homolog 2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q969F2" }, { "name": "Naked-2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q969F2" }, { "name": "hNkd2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q969F2" }, { "name": "protein naked cuticle homolog 2 isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258011", "id": "NP_001258011" }, { "name": "protein naked cuticle homolog 2; Dvl-binding protein NKD2; NKD2, WNT signaling pathway inhibitor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258011", "id": "NP_001258011" } ], "function": [ { "annotation": "Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity). Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells.", "evidence": [ { "database": "UniProtKB", "id": "Q969F2", "url": "https://www.uniprot.org/uniprot/Q969F2#function" }, { "database": "PubMed", "id": "15064403", "url": "https://glygen.org/publication/PubMed/15064403" }, { "database": "PubMed", "id": "17553928", "url": "https://glygen.org/publication/PubMed/17553928" } ] }, { "annotation": "LINC00922 regulates epithelial-mesenchymal transition, invasive and migratory capacities in breast cancer through promoting NKD2 methylation.", "evidence": [ { "database": "RefSeq", "id": "NP_001258011", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258011" }, { "database": "PubMed", "id": "33045317", "url": "https://glygen.org/publication/PubMed/33045317" } ] }, { "annotation": "NKD2 Trigger NF-kappaB Signaling Pathway and Facilitates Thyroid Cancer Cell Proliferation.", "evidence": [ { "database": "RefSeq", "id": "NP_001258011", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258011" }, { "database": "PubMed", "id": "36820951", "url": "https://glygen.org/publication/PubMed/36820951" } ] }, { "annotation": "NKD2 mediates stimulation-dependent ORAI1 trafficking to augment Ca(2+) entry in T cells.", "evidence": [ { "database": "RefSeq", "id": "NP_001258011", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258011" }, { "database": "PubMed", "id": "34433025", "url": "https://glygen.org/publication/PubMed/34433025" } ] }, { "annotation": "NKD2 phosphorylation by PKA promotes cell-surface delivery of TGFalpha and increased EGFR activation.", "evidence": [ { "database": "RefSeq", "id": "NP_001258011", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258011" }, { "database": "PubMed", "id": "30941853", "url": "https://glygen.org/publication/PubMed/30941853" } ] }, { "annotation": "NKD2 represents a candidate target of 5p amplifications in soft tissue sarcomas and might play a crucial role during the progression of this disease.", "evidence": [ { "database": "RefSeq", "id": "NP_001258011", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258011" }, { "database": "PubMed", "id": "16752383", "url": "https://glygen.org/publication/PubMed/16752383" } ] }, { "annotation": "The experiments in vitro suggested that knockdown of ZFAS1 repressed bladder cancer cell proliferation via up-regulating KLF2 and NKD2 expression, and inhibited cell migration and invasion via down-regulating ZEB1 and ZEB2 expression. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001258011", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258011" }, { "database": "PubMed", "id": "29678899", "url": "https://glygen.org/publication/PubMed/29678899" } ] }, { "annotation": "This gene encodes a member of a family of proteins that function as negative regulators of Wnt receptor signaling through interaction with Dishevelled family members. The encoded protein participates in the delivery of transforming growth factor alpha-containing vesicles to the cell membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012].", "evidence": [ { "database": "RefSeq", "id": "NP_001258011", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258011" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "Q969F2", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q969F2" } ], "glycoeffect": [], "start_pos": 175, "end_pos": 175, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "V", "sequence_mut": "I", "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (4).", "chr_id": "5", "chr_pos": "1034852", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "V175", "disease": [ { "disease_id": "DOID:4362", "recommended_name": { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "cervical cancer", "description": "A female reproductive organ cancer that is located_in the cervix." }, "synonyms": [ { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "cervical neoplasm", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "cervix cancer", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "cervix uteri cancer", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "neoplasm of uterine cervix", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "tumor of the Cervix Uteri", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "uterine cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": 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"https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": 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"MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": 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"description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "Q969F2", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q969F2" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q969F2" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "No", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "Q969F2", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q969F2" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", 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"MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "gastric cardia adenocarcinoma, susceptibility to", "description": "" }, { "id": "MIM:133239", "resource": "MIM", "url": "https://www.omim.org/entry/133239", "name": "Esophageal cancer", "description": "Esophageal cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Colorectal cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:9256", "evidence": [ { "database": "BioXpress", "id": "Q969F2", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q969F2" } ], "disease": [ { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": 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"https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q969F2", "url": "https://www.uniprot.org/uniprot/Q969F2" } ], "common_name": "Human" } ], "gene": [ { "name": "NKD2", "url": "https://www.uniprot.org/uniprot/Q969F2", "locus": { "chromosome": "CHR_HSCHR5_4_CTG1", "start_pos": 1038943, "end_pos": 1008829, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000276920", "url": "https://www.ensembl.org/id/ENSG00000276920" } ] } } ], "crossref": [ { "id": "ENSG00000145506", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000145506", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "Q969F2", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q969F2", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "NKD2", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=NKD2", "database": "GeneCards", "categories": [ "Organism-specific", "Gene Annotation" ] }, { "id": "85409", "url": "https://www.ncbi.nlm.nih.gov/gene/85409", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "17046", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=17046", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "Q969F2", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q969F2*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR002048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011992", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:85409", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:85409", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "607852", "url": "http://www.omim.org/entry/607852", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_Q969F2", "url": "https://www.nextprot.org/entry/NX_Q969F2", "database": "neXtProt", "categories": [ "Organism-specific", "Protein" ] }, { "id": "KSTKCHG", "url": "https://omabrowser.org/oma/group/KSTKCHG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5398069at2759", "url": "http://www.orthodb.org/?query=5398069at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22611", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22611", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22611:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22611:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "Q969F2", "url": "https://pharos.nih.gov/targets/Q969F2", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_Q969F2", "url": "http://purl.obolibrary.org/obo/PR_Q969F2", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001258011", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258011", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q969F2", "url": "https://www.uniprot.org/uniprot/Q969F2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q969F2-1", "url": "https://www.uniprot.org/uniprot/Q969F2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q969F2-2", "url": "https://www.uniprot.org/uniprot/Q969F2-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGKLQSKHAAAARKRRESPEGDSFVASAYASGRKGAEEAERRARDKQELPNGDPKEGPFREDQCPLQVALPAEKAEGREHPGQLLSADDGERAANREGPRGPGGQRLNIDALQCDVSVEEDDRQEWTFTLYDFDNCGKVTREDMSSLMHTIYEVVDASVNHSSGSSKTLRVKLTVSPEPSSKRKEGPPAGQDREPTRCRMEGELAEEPRVADRRLSAHVRRPSTDPQPCSERGPYCVDENTERRNHYLDLAGIENYTSRFGPGSPPVQAKQEPQGRASHLQARSRSQEPDTHAVHHRRSQVLVEHVVPASEPAARALDTQPRPKGPEKQFLKSPKGSGKPPGVPASSKSGKAFSYYLPAVLPPQAPQDGHHLPQPPPPPYGHKRYRQKGREGHSPLKAPHAQPATVEHEVVRDLPPTPAGEGYAVPVIQRHEHHHHHEHHHHHHHHHFHPS", "length": 451, "header": "sp|Q969F2-1|NKD2_HUMAN Isoform 1 of Protein naked cuticle homolog 2 OS=Homo sapiens OX=9606 GN=NKD2 PE=1 SV=1 CANONICAL=Q969F2-1" }, "isoforms": [ { "isoform_ac": "Q969F2-1", "url": "", "sequence": { "sequence": "MGKLQSKHAAAARKRRESPEGDSFVASAYASGRKGAEEAERRARDKQELPNGDPKEGPFREDQCPLQVALPAEKAEGREHPGQLLSADDGERAANREGPRGPGGQRLNIDALQCDVSVEEDDRQEWTFTLYDFDNCGKVTREDMSSLMHTIYEVVDASVNHSSGSSKTLRVKLTVSPEPSSKRKEGPPAGQDREPTRCRMEGELAEEPRVADRRLSAHVRRPSTDPQPCSERGPYCVDENTERRNHYLDLAGIENYTSRFGPGSPPVQAKQEPQGRASHLQARSRSQEPDTHAVHHRRSQVLVEHVVPASEPAARALDTQPRPKGPEKQFLKSPKGSGKPPGVPASSKSGKAFSYYLPAVLPPQAPQDGHHLPQPPPPPYGHKRYRQKGREGHSPLKAPHAQPATVEHEVVRDLPPTPAGEGYAVPVIQRHEHHHHHEHHHHHHHHHFHPS", "length": 451, "header": "sp|Q969F2-1|NKD2_HUMAN Isoform 1 of Protein naked cuticle homolog 2 OS=Homo sapiens OX=9606 GN=NKD2 PE=1 SV=1 CANONICAL=Q969F2-1" }, "locus": { "chromosome": "5", "start_pos": 1038370, "end_pos": 1009058, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000296849.10", "url": "https://www.ensembl.org/id/ENST00000296849.10" }, { "database": "Ensembl Peptide", "id": "ENSP00000296849.5", "url": "https://www.ensembl.org/id/ENSP00000296849.5" } ] } }, { "isoform_ac": "Q969F2-2", "url": "", "sequence": { "sequence": "MGKLQSKHAAAARKRRESPEGDSFVASAYASGRKGAEEAERRARDKQELPNGDPKEGPFREDQCPLQVALPAEKAEGREHPGQLLSADDGERAANREGPRGPGGQRLNIDALQCDVSVEEDDRQEWTFTLYDFDNCGKVTREDMSSLMHTIYEVVDASVNHSSGSSKTLRVKLTVSPEPSSKRKEGPPAGQDREPTRCRMEGELAEEPRVADRRLSAHVRRPSTDPQPCSERGPYCVDENTERRNHYLDLAGIENYTSRFGPGSQLCEKRSSAPRTHSGDKARGVGLCRELWSQAGHPQWPGPFPSGLVAV", "length": 311, "header": "sp|Q969F2-2|NKD2_HUMAN Isoform 2 of Protein naked cuticle homolog 2 OS=Homo sapiens OX=9606 GN=NKD2 PE=1 SV=1 CANONICAL=Q969F2-1" }, "locus": { "chromosome": "CHR_HSCHR5_4_CTG1", "start_pos": 1037665, "end_pos": 1009058, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000610777.2", "url": "https://www.ensembl.org/id/ENST00000610777.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000482896.1", "url": "https://www.ensembl.org/id/ENSP00000482896.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Vertebrate proteins related to Drosophila Naked Cuticle bind Dishevelled and antagonize Wnt signaling.", "journal": "Dev. Biol.", "date": "2001", "authors": "Wharton KA Jr, Zimmermann G, Rousset R, Scott MP", "evidence": [ { "database": "UniProtKB", "id": "Q969F2", "url": "https://www.uniprot.org/uniprot/Q969F2" } ], "reference": [ { "type": "PubMed", "id": "11356022", "url": "https://glygen.org/publication/PubMed/11356022" } ] }, { "title": "Molecular cloning, gene structure, and expression analyses of NKD1 and NKD2.", "journal": "Int. J. Oncol.", "date": "2001", "authors": "Katoh M.", "evidence": [ { "database": "UniProtKB", "id": "Q969F2", "url": "https://www.uniprot.org/uniprot/Q969F2" } ], "reference": [ { "type": "PubMed", "id": "11604995", "url": "https://glygen.org/publication/PubMed/11604995" } ] }, { "title": "Myristoylated Naked2 escorts transforming growth factor alpha to the basolateral plasma membrane of polarized epithelial cells.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2004", "authors": "Li C, Franklin JL, Graves-Deal R, Jerome WG, Cao Z, Coffey RJ", "evidence": [ { "database": "UniProtKB", "id": "Q969F2", "url": "https://www.uniprot.org/uniprot/Q969F2" } ], "reference": [ { "type": "PubMed", "id": "15064403", "url": "https://glygen.org/publication/PubMed/15064403" } ] }, { "title": "Frequent amplifications and abundant expression of TRIO, NKD2, and IRX2 in soft tissue sarcomas.", "journal": "Genes, chromosomes & cancer", "date": "2006", "authors": "Adamowicz M, Radlwimmer B, Rieker RJ, Mertens D, Schwarzbach M, Schraml P, Benner A, Lichter P, Mechtersheimer G, Joos S", "evidence": [ { "database": "RefSeq", "id": "NP_001258011", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258011" } ], "reference": [ { "type": "PubMed", "id": "16752383", "url": "https://glygen.org/publication/PubMed/16752383" } ] }, { "title": "Structural studies of human Naked2: a biologically active intrinsically unstructured protein.", "journal": "Biochem. Biophys. Res. Commun.", "date": "2006", "authors": "Li C., Krezel A.M., Hu T., Coffey R.J.", "evidence": [ { "database": "UniProtKB", "id": "Q969F2", "url": "https://www.uniprot.org/uniprot/Q969F2" } ], "reference": [ { "type": "PubMed", "id": "17045239", "url": "https://glygen.org/publication/PubMed/17045239" } ] }, { "title": "Naked2 acts as a cargo recognition and targeting protein to ensure proper delivery and fusion of TGF-{alpha} containing exocytic vesicles at the lower lateral membrane of polarized MDCK cells.", "journal": "Mol. Biol. Cell", "date": "2007", "authors": "Li C., Hu J., Ding W., Cao Z., Coffey R.J., Hao M., Piston D.W., Graves-Deal R.", "evidence": [ { "database": "UniProtKB", "id": "Q969F2", "url": "https://www.uniprot.org/uniprot/Q969F2" } ], "reference": [ { "type": "PubMed", "id": "17553928", "url": "https://glygen.org/publication/PubMed/17553928" } ] }, { "title": "EGF receptor-independent action of TGF-alpha protects Naked2 from AO7-mediated ubiquitylation and proteasomal degradation.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2008", "authors": "Ding W, Li C, Hu T, Graves-Deal R, Fotia AB, Weissman AM, Coffey RJ", "evidence": [ { "database": "UniProtKB", "id": "Q969F2", "url": "https://www.uniprot.org/uniprot/Q969F2" } ], "reference": [ { "type": "PubMed", "id": "18757723", "url": "https://glygen.org/publication/PubMed/18757723" } ] }, { "title": "ZFAS1 functions as an oncogenic long non-coding RNA in bladder cancer.", "journal": "Bioscience reports", "date": "2018", "authors": "Yang H, Li G, Cheng B, Jiang R", "evidence": [ { "database": "RefSeq", "id": "NP_001258011", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258011" } ], "reference": [ { "type": "PubMed", "id": "29678899", "url": "https://glygen.org/publication/PubMed/29678899" } ] }, { "title": "Protein kinase A-mediated phosphorylation of naked cuticle homolog 2 stimulates cell-surface delivery of transforming growth factor-alpha for epidermal growth factor receptor transactivation.", "journal": "Traffic (Copenhagen, Denmark)", "date": "2019", "authors": "Cao Z, Singh B, Li C, Markham NO, Carrington LJ, Franklin JL, Graves-Deal R, Kennedy EJ, Goldenring JR, Coffey RJ", "evidence": [ { "database": "RefSeq", "id": "NP_001258011", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258011" } ], "reference": [ { "type": "PubMed", "id": "30941853", "url": "https://glygen.org/publication/PubMed/30941853" } ] }, { "title": "LINC00922 regulates epithelial-mesenchymal transition, invasive and migratory capacities in breast cancer through promoting NKD2 methylation.", "journal": "Cellular signalling", "date": "2021", "authors": "Wang Y, Dong T, Wang P, Li S, Wu G, Zhou J, Wang Z", "evidence": [ { "database": "RefSeq", "id": "NP_001258011", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258011" } ], "reference": [ { "type": "PubMed", "id": "33045317", "url": "https://glygen.org/publication/PubMed/33045317" } ] }, { "title": "NKD2 mediates stimulation-dependent ORAI1 trafficking to augment Ca(2+) entry in T cells.", "journal": "Cell reports", "date": "2021", "authors": "Wu B, Woo JS, Vila P, Jew M, Leung J, Sun Z, Srikanth S, Gwack Y", "evidence": [ { "database": "RefSeq", "id": "NP_001258011", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258011" } ], "reference": [ { "type": "PubMed", "id": "34433025", "url": "https://glygen.org/publication/PubMed/34433025" } ] }, { "title": "NKD2 Trigger NF-\u03baB Signaling Pathway and Facilitates Thyroid Cancer Cell Proliferation.", "journal": "Molecular biotechnology", "date": "2023-11", "authors": "Ke Shaoying, Pan Qunxiong, Wang Congren, Su Zijian, Li Mingzhu, Liu Xiaoyu", "evidence": [ { "database": "RefSeq", "id": "NP_001258011", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258011" } ], "reference": [ { "type": "PubMed", "id": "36820951", "url": "https://glygen.org/publication/PubMed/36820951" } ] } ], "pathway": [ { "id": "hsa:85409", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:85409", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D4A182-1", "protein_name": "Protein naked cuticle homolog", "gene_name": "Nkd2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGKFQSKHACKRRESPEGDSFVVSAYASGRKGAEETDRRAGSGVEHRARDKQELPNGDPKEGPFWEDKGSLEVVLPPEKSEGHEGQLFSVDDGEKAANREGPLRLSKKHLNIDALQCDVSVEEDNRQEWTFTLYDFDNSGKVTREDMSSLMHTIYEVVDASVNHSSGSSKTLRVKLTVSPEPSSKKEWLPPGQEREPTRGRTESELPDDPRVADRRLSAYSRKPNTDPQPCPVRVPYCVDENTERRNHYLDLAGIENYTSKFGPGSPPEQARQEHHGRATHIPSRSRSQESDAHAIHHRRSQVLAEHIVPANEPAPRALAAQPRLKGQEKQFLRSPKGPGKPLGAPSGSKPGKSLSHCLQAVPLSQGAQDGHHLPQPPPQPPPQPYGHKRYRQKSREGHSPLKGHGQPTMVEHEVVRDLPPMLGPEGYVVPMIQRHEHHHHHEHHHHHHHHHFHPNAS", "length": 458 }, "evidence": [ { "id": "45229461", "url": "http://www.informatics.jax.org/homology/45229461", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8VE28-1", "protein_name": "Protein naked cuticle homolog 2", "gene_name": "Nkd2", "tax_id": 10090, "organism": "Mus musculus", 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