{ "uniprot_canonical_ac": "Q960X8-1", "uniprot_ac": "Q960X8", "uniprot_id": "HRS_DROME", "mass": { "chemical_mass": 85415.0, "monoisotopic_mass": 85415.0 }, "refseq": { "ac": "NP_525099", "name": "hepatocyte growth factor regulated tyrosine kinase substrate, isoform B", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_525099" }, "gene_names": [ { "name": "Hrs", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q960X8", "id": "Q960X8" }, { "name": "CG2903; dHrs; Dmel\\CG2903; DmHRS; hrs; HRS; HRS-2; l(2)23AB5; l(2)23Ad; l(2)23Ad(Hrs); vps27; Vps27", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_525099", "id": "NP_525099" }, { "name": "CG2903", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q960X8", "id": "Q960X8" }, { "name": "Hrs", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_525099", "id": "NP_525099" } ], "protein_names": [ { "name": "Hepatocyte growth factor-regulated tyrosine kinase substrate", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q960X8" }, { "name": "CG2903-PB; Hrs-PB; F[[1]]F[[0]] ATPase; hepatocyte growth factor regulated tyrosine kinase; HGF-regulated tyrosine kinase substrate; hepatocyte growth factor-regulated tyrosine kinase substrate; hepatocyte growth-factor-regulated substrate; hepatocyte growth factor-regulated tyrosine substrate", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_525099", "id": "NP_525099" }, { "name": "hepatocyte growth factor regulated tyrosine kinase substrate, isoform B", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_525099", "id": "NP_525099" } ], "function": [ { "annotation": "Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.", "evidence": [ { "database": "UniProtKB", "id": "Q960X8", "url": "https://www.uniprot.org/uniprot/Q960X8#function" }, { "database": "PubMed", "id": "11832215", "url": "https://glygen.org/publication/PubMed/11832215" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Drosophila melanogaster", "taxid": 7227, "evidence": [ { "database": "UniProtKB", "id": "Q960X8", "url": "https://www.uniprot.org/uniprot/Q960X8" } ], "common_name": "Fruit fly" } ], "gene": [ { "name": "Hrs", "url": "https://www.uniprot.org/uniprot/Q960X8", "locus": { "chromosome": "2L", "start_pos": 2743377, "end_pos": 2739986, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "FBgn0031450", "url": "https://www.ensembl.org/id/FBgn0031450" } ] } } ], "crossref": [ { "id": "FBgn0031450", "url": "https://bgee.org/?page=gene&gene_id=FBgn0031450", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd03569", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd03569", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd15720", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd15720", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd21387", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd21387", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "FBgn0031450", "url": "https://flybase.org/reports/FBgn0031450", "database": "FlyBase", "categories": [ "Organism-specific" ] }, { "id": "33458", "url": "https://www.ncbi.nlm.nih.gov/gene/33458", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "Q960X8", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q960X8*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000306", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000306", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002014", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002014", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003903", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003903", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008942", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008942", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011011", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011011", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013083", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017073", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017073", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017455", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017455", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024641", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024641", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "dme:Dmel_CG2903", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG2903", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "DQQCSAK", "url": "https://omabrowser.org/oma/group/DQQCSAK/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "922060at2759", "url": "http://www.orthodb.org/?query=922060at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR46275", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46275", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46275:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46275:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "1DVP", "url": "https://www.rcsb.org/structure/1DVP", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00790", "url": "http://pfam.xfam.org/family/PF00790", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF01363", "url": "http://pfam.xfam.org/family/PF01363", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF12210", "url": "http://pfam.xfam.org/family/PF12210", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q960X8", "url": "http://purl.obolibrary.org/obo/PR_Q960X8", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-DME-182971", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-182971", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DME-432720", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-432720", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DME-5689880", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-5689880", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DME-8856825", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-8856825", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DME-8856828", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-8856828", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DME-9013420", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-9013420", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-DME-917729", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-917729", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_525099", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_525099", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "Q960X8", "url": "https://www.uniprot.org/uniprot/Q960X8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q960X8-1", "url": "https://www.uniprot.org/uniprot/Q960X8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q960X8-2", "url": "https://www.uniprot.org/uniprot/Q960X8-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFRSSFDKNLENATSHLRLEPDWPSILLICDEINQKDVTPKNAFAAIKKKMNSPNPHSSCYSLLVLESIVKNCGAPVHEEVFTKENCEMFSSFLESTPHENVRQKMLELVQTWAYAFRSSDKYQAIKDTMTILKAKGHTFPELREADAMFTADTAPNWADGRVCHRCRVEFTFTNRKHHCRNCGQVFCGQCTAKQCPLPKYGIEKEVRVCDGCFAALQRPTSGSGGAKSGPRPADSELPAEYLNSTLAQQVQTPARKTEQELKEEEELQLALALSQSEAEQQKPKLQSLPPAAYRMQQRSPSPEAPPEPKEYHQQPEEATNPELAKYLNRSYWEQRKISESSSMASPSAPSPMPPTPQPQQIMPLQVKSADEVQIDEFAANMRTQVEIFVNRMKSNSSRGRSISNDSSVQTLFMTLTSLHSQQLSYIKEMDDKRMWYEQLQDKLTQIKDSRAALDQLRQEHVEKLRRIAEEQERQRQMQMAQKLDIMRKKKQEYLQYQRQLALQRIQEQEREMQLRQEQQKAQYLMGQSAPPFPYMPPSAVPQHGSPSHQLNNVYNPYAAGVPGYLPQGPAPAPNGHGQFQAIPPGMYNPAIQQPMPPNLQPGGLMQQPAPPGNPQMMPPMPENQFANNPAAILQLPQQHSIAQPPQIPFQPQPQQIPGQQPQQIPGQQPQQIPGQQPQQIPGQQPQQIPVQQPQPQPQMGHVMLQQHQAPPAAQAPPVTEIANNQVQAVAAAPAPPQNEPGPAPVKAEEPATAELISFD", "length": 760, "header": "sp|Q960X8-1|HRS_DROME Isoform 1 of Hepatocyte growth factor-regulated tyrosine kinase substrate OS=Drosophila melanogaster OX=7227 GN=Hrs PE=1 SV=1 CANONICAL=Q960X8-1" }, "isoforms": [ { "isoform_ac": "Q960X8-1", "url": "", "sequence": { "sequence": "MFRSSFDKNLENATSHLRLEPDWPSILLICDEINQKDVTPKNAFAAIKKKMNSPNPHSSCYSLLVLESIVKNCGAPVHEEVFTKENCEMFSSFLESTPHENVRQKMLELVQTWAYAFRSSDKYQAIKDTMTILKAKGHTFPELREADAMFTADTAPNWADGRVCHRCRVEFTFTNRKHHCRNCGQVFCGQCTAKQCPLPKYGIEKEVRVCDGCFAALQRPTSGSGGAKSGPRPADSELPAEYLNSTLAQQVQTPARKTEQELKEEEELQLALALSQSEAEQQKPKLQSLPPAAYRMQQRSPSPEAPPEPKEYHQQPEEATNPELAKYLNRSYWEQRKISESSSMASPSAPSPMPPTPQPQQIMPLQVKSADEVQIDEFAANMRTQVEIFVNRMKSNSSRGRSISNDSSVQTLFMTLTSLHSQQLSYIKEMDDKRMWYEQLQDKLTQIKDSRAALDQLRQEHVEKLRRIAEEQERQRQMQMAQKLDIMRKKKQEYLQYQRQLALQRIQEQEREMQLRQEQQKAQYLMGQSAPPFPYMPPSAVPQHGSPSHQLNNVYNPYAAGVPGYLPQGPAPAPNGHGQFQAIPPGMYNPAIQQPMPPNLQPGGLMQQPAPPGNPQMMPPMPENQFANNPAAILQLPQQHSIAQPPQIPFQPQPQQIPGQQPQQIPGQQPQQIPGQQPQQIPGQQPQQIPVQQPQPQPQMGHVMLQQHQAPPAAQAPPVTEIANNQVQAVAAAPAPPQNEPGPAPVKAEEPATAELISFD", "length": 760, "header": "sp|Q960X8-1|HRS_DROME Isoform 1 of Hepatocyte growth factor-regulated tyrosine kinase substrate OS=Drosophila melanogaster OX=7227 GN=Hrs PE=1 SV=1 CANONICAL=Q960X8-1" }, "locus": { "chromosome": "2L", "start_pos": 2743082, "end_pos": 2740181, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0089750", "url": "https://www.ensembl.org/id/FBtr0089750" }, { "database": "Ensembl Peptide", "id": "FBpp0088691", "url": "https://www.ensembl.org/id/FBpp0088691" } ] } }, { "isoform_ac": "Q960X8-2", "url": "", "sequence": { "sequence": "MSSEEELSIEEESLDTMTILKAKGHTFPELREADAMFTADTAPNWADGRVCHRCRVEFTFTNRKHHCRNCGQVFCGQCTAKQCPLPKYGIEKEVRVCDGCFAALQRPTSGSGGAKSGPRPADSELPAEYLNSTLAQQVQTPARKTEQELKEEEELQLALALSQSEAEQQKPKLQSLPPAAYRMQQRSPSPEAPPEPKEYHQQPEEATNPELAKYLNRSYWEQRKISESSSMASPSAPSPMPPTPQPQQIMPLQVKSADEVQIDEFAANMRTQVEIFVNRMKSNSSRGRSISNDSSVQTLFMTLTSLHSQQLSYIKEMDDKRMWYEQLQDKLTQIKDSRAALDQLRQEHVEKLRRIAEEQERQRQMQMAQKLDIMRKKKQEYLQYQRQLALQRIQEQEREMQLRQEQQKAQYLMGQSAPPFPYMPPSAVPQHGSPSHQLNNVYNPYAAGVPGYLPQGPAPAPNGHGQFQAIPPGMYNPAIQQPMPPNLQPGGLMQQPAPPGNPQMMPPMPENQFANNPAAILQLPQQHSIAQPPQIPFQPQPQQIPGQQPQQIPGQQPQQIPGQQPQQIPGQQPQQIPVQQPQPQPQMGHVMLQQHQAPPAAQAPPVTEIANNQVQAVAAAPAPPQNEPGPAPVKAEEPATAELISFD", "length": 647, "header": "sp|Q960X8-2|HRS_DROME Isoform 2 of Hepatocyte growth factor-regulated tyrosine kinase substrate OS=Drosophila melanogaster OX=7227 GN=Hrs PE=1 SV=1 CANONICAL=Q960X8-1" }, "locus": { "chromosome": "2L", "start_pos": 2743082, "end_pos": 2741010, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "FBtr0089749", "url": "https://www.ensembl.org/id/FBtr0089749" }, { "database": "Ensembl Peptide", "id": "FBpp0088690", "url": "https://www.ensembl.org/id/FBpp0088690" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 300, "end_pos": 300, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q960X8", "url": "https://www.uniprot.org/uniprot/Q960X8" }, { "database": "PubMed", "id": "18327897", "url": "https://glygen.org/publication/PubMed/18327897" }, { "database": "phospho.ELM", "id": "Q960X8", "url": "http://phospho.elm.eu.org/byAccession/Q960X8.html" }, { "database": "iPTMnet", "id": "Q960X8", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q960X8" } ], "site_lbl": "Ser300" }, { "start_pos": 302, "end_pos": 302, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q960X8", "url": "https://www.uniprot.org/uniprot/Q960X8" }, { "database": "PubMed", "id": "18327897", "url": "https://glygen.org/publication/PubMed/18327897" }, { "database": "phospho.ELM", "id": "Q960X8", "url": "http://phospho.elm.eu.org/byAccession/Q960X8.html" }, { "database": "iPTMnet", "id": "Q960X8", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q960X8" } ], "site_lbl": "Ser302" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Crystal structure of the VHS and FYVE tandem domains of Hrs, a protein involved in membrane trafficking and signal transduction.", "journal": "Cell", "date": "2000", "authors": "Mao Y., Quiocho F.A., Duan X., Lloyd T.E., Bellen H., Wu M.N., Nickitenko A.", "evidence": [ { "database": "UniProtKB", "id": "Q960X8", "url": "https://www.uniprot.org/uniprot/Q960X8" } ], "reference": [ { "type": "PubMed", "id": "10693761", "url": "https://glygen.org/publication/PubMed/10693761" } ] }, { "title": "The genome sequence of Drosophila melanogaster.", "journal": "Science", "date": "2000", "authors": "Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA, Galle RF, George RA, Lewis SE, Richards S, Ashburner M, Henderson SN, Sutton GG, Wortman JR, Yandell MD, Zhang Q, Chen LX, Brandon RC, Rogers YH, Blazej RG, Champe M, Pfeiffer BD, Wan KH, Doyle C, Baxter EG, Helt G, Nelson CR, Gabor GL, Abril JF, Agbayani A, An HJ, Andrews-Pfannkoch C, Baldwin D, Ballew RM, Basu A, Baxendale J, Bayraktaroglu L, Beasley EM, Beeson KY, Benos PV, Berman BP, Bhandari D, Bolshakov S, Borkova D, Botchan MR, Bouck J, Brokstein P, Brottier P, Burtis KC, Busam DA, Butler H, Cadieu E, Center A, Chandra I, Cherry JM, Cawley S, Dahlke C, Davenport LB, Davies P, de Pablos B, Delcher A, Deng Z, Mays AD, Dew I, Dietz SM, Dodson K, Doup LE, Downes M, Dugan-Rocha S, Dunkov BC, Dunn P, Durbin KJ, Evangelista CC, Ferraz C, Ferriera S, Fleischmann W, Fosler C, Gabrielian AE, Garg NS, Gelbart WM, Glasser K, Glodek A, Gong F, Gorrell JH, Gu Z, Guan P, Harris M, Harris NL, Harvey D, Heiman TJ, Hernandez JR, Houck J, Hostin D, Houston KA, Howland TJ, Wei MH, Ibegwam C, Jalali M, Kalush F, Karpen GH, Ke Z, Kennison JA, Ketchum KA, Kimmel BE, Kodira CD, Kraft C, Kravitz S, Kulp D, Lai Z, Lasko P, Lei Y, Levitsky AA, Li J, Li Z, Liang Y, Lin X, Liu X, Mattei B, McIntosh TC, McLeod MP, McPherson D, Merkulov G, Milshina NV, Mobarry C, Morris J, Moshrefi A, Mount SM, Moy M, Murphy B, Murphy L, Muzny DM, Nelson DL, Nelson DR, Nelson KA, Nixon K, Nusskern DR, Pacleb JM, Palazzolo M, Pittman GS, Pan S, Pollard J, Puri V, Reese MG, Reinert K, Remington K, Saunders RD, Scheeler F, Shen H, Shue BC, Siden-Kiamos I, Simpson M, Skupski MP, Smith T, Spier E, Spradling AC, Stapleton M, Strong R, Sun E, Svirskas R, Tector C, Turner R, Venter E, Wang AH, Wang X, Wang ZY, Wassarman DA, Weinstock GM, Weissenbach J, Williams SM, WoodageT, Worley KC, Wu D, Yang S, Yao QA, Ye J, Yeh RF, Zaveri JS, Zhan M, Zhang G, Zhao Q, Zheng L, Zheng XH, Zhong FN, Zhong W, Zhou X, Zhu S, Zhu X, Smith HO, Gibbs RA, Myers EW, Rubin GM, Venter JC", "evidence": [ { "database": "UniProtKB", "id": "Q960X8", "url": "https://www.uniprot.org/uniprot/Q960X8" } ], "reference": [ { "type": "PubMed", "id": "10731132", "url": "https://glygen.org/publication/PubMed/10731132" } ] }, { "title": "Hrs regulates endosome membrane invagination and tyrosine kinase receptor signaling in Drosophila.", "journal": "Cell", "date": "2002", "authors": "Zhou Y., Bellen H.J., Lloyd T.E., Pennetta G., Atkinson R., Wu M.N.", "evidence": [ { "database": "UniProtKB", "id": "Q960X8", "url": "https://www.uniprot.org/uniprot/Q960X8" } ], "reference": [ { "type": "PubMed", "id": "11832215", "url": "https://glygen.org/publication/PubMed/11832215" } ] }, { "title": "A Drosophila full-length cDNA resource.", "journal": "Genome Biol.", "date": "2002", "authors": "Stapleton M, Carlson J, Brokstein P, Yu C, Champe M, George R, Guarin H, Kronmiller B, Pacleb J, Park S, Wan K, Rubin GM, Celniker SE", "evidence": [ { "database": "UniProtKB", "id": "Q960X8", "url": "https://www.uniprot.org/uniprot/Q960X8" } ], "reference": [ { "type": "PubMed", "id": "12537569", "url": "https://glygen.org/publication/PubMed/12537569" } ] }, { "title": "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.", "journal": "Genome Biol.", "date": "2002", "authors": "Misra S, Crosby MA, Mungall CJ, Matthews BB, Campbell KS, Hradecky P, Huang Y, Kaminker JS, Millburn GH, Prochnik SE, Smith CD, Tupy JL, Whitfied EJ, Bayraktaroglu L, Berman BP, Bettencourt BR, Celniker SE, de Grey AD, Drysdale RA, Harris NL, Richter J, Russo S, Schroeder AJ, Shu SQ, Stapleton M, Yamada C, Ashburner M, Gelbart WM, Rubin GM, Lewis SE", "evidence": [ { "database": "UniProtKB", "id": "Q960X8", "url": "https://www.uniprot.org/uniprot/Q960X8" } ], "reference": [ { "type": "PubMed", "id": "12537572", "url": "https://glygen.org/publication/PubMed/12537572" } ] }, { "title": "Phosphoproteome analysis of Drosophila melanogaster embryos.", "journal": "Journal of proteome research", "date": "2008", "authors": "Zhai B, Villen J, Beausoleil SA, Mintseris J, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "Q960X8", "url": "https://www.uniprot.org/uniprot/Q960X8" }, { "database": "iPTMnet", "id": "Q960X8", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q960X8" } ], "reference": [ { "type": "PubMed", "id": "18327897", "url": "https://glygen.org/publication/PubMed/18327897" } ] } ], "pathway": [ { "id": "dme:Dmel_CG2903", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+dme:Dmel_CG2903", "resource": "KEGG Pathway" }, { "id": "R-DME-182971", "name": "EGFR downregulation", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-182971", "resource": "Reactome", "description": "EGFR downregulation" }, { "id": "R-DME-432720", "name": "Lysosome Vesicle Biogenesis", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-432720", "resource": "Reactome", "description": "Lysosome Vesicle Biogenesis" }, { "id": "R-DME-5689880", "name": "Ub-specific processing proteases", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-5689880", "resource": "Reactome", "description": "Ub-specific processing proteases" }, { "id": "R-DME-8856825", "name": "Cargo recognition for clathrin-mediated endocytosis", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-8856825", "resource": "Reactome", "description": "Cargo recognition for clathrin-mediated endocytosis" }, { "id": "R-DME-8856828", "name": "Clathrin-mediated endocytosis", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-8856828", "resource": "Reactome", "description": "Clathrin-mediated endocytosis" }, { "id": "R-DME-9013420", "name": "RHOU GTPase cycle", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-9013420", "resource": "Reactome", "description": "RHOU GTPase cycle" }, { "id": "R-DME-917729", "name": "Endosomal Sorting Complex Required For Transport (ESCRT)", "url": "https://www.reactome.org/PathwayBrowser/#R-DME-917729", "resource": "Reactome", "description": "Endosomal Sorting Complex Required For Transport (ESCRT)" } ], "orthologs": [ { "uniprot_canonical_ac": "O14964-1", "protein_name": "Hepatocyte growth factor-regulated tyrosine kinase substrate", "gene_name": "HGS", "tax_id": 9606, "organism": "Homo sapiens", "sequence": { "sequence": 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