{ "uniprot_canonical_ac": "Q93008-1", "uniprot_ac": "Q93008", "uniprot_id": "USP9X_HUMAN", "mass": { "chemical_mass": 290463.0, "monoisotopic_mass": 290463.0 }, "refseq": { "ac": "XP_005272732", "name": "probable ubiquitin carboxyl-terminal hydrolase FAF-X isoform X1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005272732" }, "gene_names": [ { "name": "USP9X", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q93008", "id": "Q93008" }, { "name": "DFFRX; FAF; FAM; hFAM; MRX99; MRXS99F; XLID99", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005272733", "id": "XP_005272733" }, { "name": "DFFRX", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q93008", "id": "Q93008" }, { "name": "FAM", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q93008", "id": "Q93008" }, { "name": "USP9X", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005272733", "id": "XP_005272733" }, { "name": "USP9", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q93008", "id": "Q93008" } ], "protein_names": [ { "name": "Probable ubiquitin carboxyl-terminal hydrolase FAF-X", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q93008" }, { "name": "3.4.19.12", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q93008" }, { "name": "Deubiquitinating enzyme FAF-X", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q93008" }, { "name": "Drosophila fat facets related, X-linked; ubiquitin specific protease 9, X chromosome (fat facets-like Drosophila); ubiquitin thiolesterase FAF-X; ubiquitin-specific processing protease FAF-X; deubiquitinating enzyme FAF-X; fat facets protein related, X-linked; probable ubiquitin carboxyl-terminal hydrolase FAF-X; fat facets in mammals; ubiquitin thioesterase FAF-X; ubiquitin-specific protease 9, X chromosome", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034679", "id": "NP_001034679" }, { "name": "Fat facets in mammals", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q93008" }, { "name": "Fat facets protein-related, X-linked", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q93008" }, { "name": "Ubiquitin thioesterase FAF-X", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q93008" }, { "name": "Ubiquitin-specific protease 9, X chromosome", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q93008" }, { "name": "Ubiquitin-specific-processing protease FAF-X", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q93008" }, { "name": "hFAM", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q93008" }, { "name": "probable ubiquitin carboxyl-terminal hydrolase FAF-X isoform 3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034679", "id": "NP_001034679" }, { "name": "probable ubiquitin carboxyl-terminal hydrolase FAF-X isoform X1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005272732", "id": "XP_005272732" }, { "name": "probable ubiquitin carboxyl-terminal hydrolase FAF-X isoform X3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005272733", "id": "XP_005272733" } ], "function": [ { "annotation": "Deubiquitinase USP9X loss sensitizes renal cancer cells to mTOR inhibition.", "evidence": [ { "database": "RefSeq", "id": "NP_001034679", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034679" }, { "database": "PubMed", "id": "37260183", "url": "https://glygen.org/publication/PubMed/37260183" } ] }, { "annotation": "Deubiquitinase USP9X stabilizes RNA m[6]A demethylase ALKBH5 and promotes acute myeloid leukemia cell survival.", "evidence": [ { "database": "RefSeq", "id": "NP_001034679", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034679" }, { "database": "PubMed", "id": "37454738", "url": "https://glygen.org/publication/PubMed/37454738" } ] }, { "annotation": "Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins (PubMed:19135894, PubMed:25944111, PubMed:18254724, PubMed:22371489, PubMed:29626158). May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin (PubMed:19135894, PubMed:25944111, PubMed:22371489, PubMed:18254724, PubMed:29626158). Specifically hydrolyzes 'Lys-63'-, 'Lys-48'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains (PubMed:25944111, PubMed:18254724, PubMed:33378666). Essential component of TGF-beta/BMP signaling cascade (PubMed:19135894). Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33 (PubMed:19135894). Deubiquitinates alkylation repair enzyme ALKBH3 (PubMed:25944111). OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111). Deubiquitinates mTORC2 complex component RICTOR at 'Lys-294' by removing 'Lys-63'-linked polyubiquitin chains, stabilizing RICTOR and enhancing its binding to MTOR, thus promoting mTORC2 complex assembly (PubMed:33378666). Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres (PubMed:16322459). Involved in axonal growth and neuronal cell migration (PubMed:24607389). Regulates cellular clock function by enhancing the protein stability and transcriptional activity of the core circadian protein BMAL1 via its deubiquitinating activity (PubMed:29626158). Acts as a regulator of peroxisome import by mediating deubiquitination of PEX5: specifically deubiquitinates PEX5 monoubiquitinated at 'Cys-11' following its retrotranslocation into the cytosol, resetting PEX5 for a subsequent import cycle (PubMed:22371489). Deubiquitinates PEG10 (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008#function" }, { "database": "PubMed", "id": "19135894", "url": "https://glygen.org/publication/PubMed/19135894" }, { "database": "PubMed", "id": "24607389", "url": "https://glygen.org/publication/PubMed/24607389" }, { "database": "PubMed", "id": "16322459", "url": "https://glygen.org/publication/PubMed/16322459" }, { "database": "PubMed", "id": "25944111", "url": "https://glygen.org/publication/PubMed/25944111" }, { "database": "PubMed", "id": "18254724", "url": "https://glygen.org/publication/PubMed/18254724" }, { "database": "PubMed", "id": "33378666", "url": "https://glygen.org/publication/PubMed/33378666" }, { "database": "UniProtKB", "id": "P70398", "url": "https://www.uniprot.org/uniprot/P70398#function" }, { "database": "PubMed", "id": "22371489", "url": "https://glygen.org/publication/PubMed/22371489" }, { "database": "PubMed", "id": "29626158", "url": "https://glygen.org/publication/PubMed/29626158" } ] }, { "annotation": "FAM associates with E-cadherin and beta-catenin during trafficking to the plasma membrane", "evidence": [ { "database": "RefSeq", "id": "NP_001034679", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034679" }, { "database": "PubMed", "id": "14742711", "url": "https://glygen.org/publication/PubMed/14742711" } ] }, { "annotation": "KSHV Viral Protein Kinase Interacts with USP9X to Modulate the Viral Lifecycle.", "evidence": [ { "database": "RefSeq", "id": "NP_001034679", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034679" }, { "database": "PubMed", "id": "36995092", "url": "https://glygen.org/publication/PubMed/36995092" } ] }, { "annotation": "This gene is a member of the peptidase C19 family and encodes a protein that is similar to ubiquitin-specific proteases. Though this gene is located on the X chromosome, it escapes X-inactivation. Mutations in this gene have been associated with Turner syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001034679", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034679" } ] }, { "annotation": "USP9X deubiquitinates and stabilizes CDC123 to promote breast carcinogenesis through regulating cell cycle.", "evidence": [ { "database": "RefSeq", "id": "NP_001034679", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034679" }, { "database": "PubMed", "id": "37314216", "url": "https://glygen.org/publication/PubMed/37314216" } ] }, { "annotation": "USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities.", "evidence": [ { "database": "RefSeq", "id": "NP_001034679", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034679" }, { "database": "PubMed", "id": "37030295", "url": "https://glygen.org/publication/PubMed/37030295" } ] } ], "disease": [ { "disease_id": "DOID:0112025", "recommended_name": { "id": "DOID:0112025", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112025", "name": "female-restricted syndromic X-linked intellectual disability 99", "description": "A syndromic X-linked intellectual disability characterized by delayed psychomotor development, mild to moderate intellectual disability, and a wide range of additional congenital anomalies that has_material_basis_in heterozygous mutation in the USP9X gene on chromosome Xp11.4." }, "synonyms": [ { "id": "DOID:0112025", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112025", "name": "X-linked female restricted facial dysmorphism-short stature-choanal atresia-intellectual disability", "description": "" }, { "id": "DOID:0112025", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112025", "name": "MRXS99F", "description": "" }, { "id": "DOID:0112025", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112025", "name": "female-restricted syndromic X-linked mental retardation 99", "description": "" }, { "id": "MONDO:0010502", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010502", "name": "intellectual disability, X-linked 99, syndromic, female-restricted", "description": "Any X-linked syndromic intellectual disability in which the cause of the disease is a mutation in the USP9X gene." }, { "id": "MONDO:0010502", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010502", "name": "MRXS99F", "description": "" }, { "id": "MONDO:0010502", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010502", "name": "USP9X X-linked syndromic intellectual disability", "description": "" }, { "id": "MONDO:0010502", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010502", "name": "X-linked syndromic intellectual disability caused by mutation in USP9X", "description": "" }, { "id": "MONDO:0010502", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010502", "name": "intellectual developmental disorder, X-linked 99, syndromic, female-restricted, X-linked dominant", "description": "" }, { "id": "MONDO:0010502", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010502", "name": "intellectual disability, X-linked 99, syndromic, female-restricted", "description": "" }, { "id": "MONDO:0010502", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010502", "name": "mental retardation, X-linked 99, syndromic, female-restricted", "description": "" }, { "id": "MIM:300968", "resource": "MIM", "url": "https://www.omim.org/entry/300968", "name": "Intellectual developmental disorder, X-linked 99, syndromic, female-restricted", "description": "Intellectual developmental disorder, X-linked 99, syndromic, female-restricted" } ], "evidence": [ { "id": "300968", "database": "MIM", "url": "https://www.omim.org/entry/300968" } ] }, { "disease_id": "DOID:0112026", "recommended_name": { "id": "DOID:0112026", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112026", "name": "non-syndromic X-linked intellectual disability 99", "description": "A non-syndromic X-linked intellectual disability characterized by developmental delay, hypotonia, and variable behavioral abnormalities that has_material_basis_in hemizygous mutation in the USP9X gene on chromosome Xp11.4." }, "synonyms": [ { "id": "DOID:0112026", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112026", "name": "MRX99", "description": "" }, { "id": "DOID:0112026", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0112026", "name": "X-linked mental retardation 99", "description": "" }, { "id": "MONDO:0010487", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010487", "name": "intellectual disability, X-linked 99", "description": "Any non-syndromic X-linked intellectual disability in which the cause of the disease is a mutation in the USP9X gene." }, { "id": "MONDO:0010487", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010487", "name": "USP9X non-syndromic X-linked intellectual disability", "description": "" }, { "id": "MONDO:0010487", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010487", "name": "intellectual developmental disorder, X-linked 99, X-linked recessive", "description": "" }, { "id": "MONDO:0010487", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010487", "name": "intellectual disability, X-linked 99", "description": "" }, { "id": "MONDO:0010487", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010487", "name": "intellectual disability, X-linked type 99", "description": "" }, { "id": "MONDO:0010487", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010487", "name": "mental retardation, X-linked type 99", "description": "" }, { "id": "MONDO:0010487", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010487", "name": "non-syndromic X-linked intellectual disability caused by mutation in USP9X", "description": "" }, { "id": "MONDO:0010487", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010487", "name": "MRX99", "description": "" }, { "id": "MONDO:0010487", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010487", "name": "mental retardation, X-linked 99", "description": "" }, { "id": "MIM:300919", "resource": "MIM", "url": "https://www.omim.org/entry/300919", "name": "Intellectual developmental disorder, X-linked 99", "description": "Intellectual developmental disorder, X-linked 99" } ], "evidence": [ { "id": "300919", "database": "MIM", "url": "https://www.omim.org/entry/300919" } ] } ], "snv": [ { "evidence": [ { "id": "Q93008", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/Q93008" } ], "glycoeffect": [], "start_pos": 1896, "end_pos": 1896, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "R", "sequence_mut": "C", "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (3).", "chr_id": "X", "chr_pos": "41216253", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "R1896", "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] }, { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", 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"name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, 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"http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "Q93008", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q93008" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ] } ] }, { "significant": "No", "trend": "down", "name": "Head and neck cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "Q93008", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q93008" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Lung cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1324", "evidence": [ { "database": "BioXpress", "id": "Q93008", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/Q93008" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": 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"A0A994J4R6-1", "url": "https://www.uniprot.org/uniprot/A0A994J4R6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A994J4T3", "url": "https://www.uniprot.org/uniprot/A0A994J4T3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A994J4T3-1", "url": "https://www.uniprot.org/uniprot/A0A994J4T3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A994J4T8", "url": "https://www.uniprot.org/uniprot/A0A994J4T8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A994J4T8-1", "url": "https://www.uniprot.org/uniprot/A0A994J4T8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A994J583", "url": "https://www.uniprot.org/uniprot/A0A994J583", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A994J583-1", "url": "https://www.uniprot.org/uniprot/A0A994J583-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A994J588", "url": "https://www.uniprot.org/uniprot/A0A994J588", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A994J588-1", "url": "https://www.uniprot.org/uniprot/A0A994J588-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A994J6S4", "url": "https://www.uniprot.org/uniprot/A0A994J6S4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A994J6S4-1", "url": "https://www.uniprot.org/uniprot/A0A994J6S4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A994J766", "url": "https://www.uniprot.org/uniprot/A0A994J766", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A994J766-1", "url": "https://www.uniprot.org/uniprot/A0A994J766-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A994J7K1", "url": "https://www.uniprot.org/uniprot/A0A994J7K1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A994J7K1-1", "url": "https://www.uniprot.org/uniprot/A0A994J7K1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q93008-1", "url": "https://www.uniprot.org/uniprot/Q93008-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q93008-3", "url": "https://www.uniprot.org/uniprot/Q93008-3", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MTATTRGSPVGGNDNQGQAPDGQSQPPLQQNQTSSPDSSNENSPATPPDEQGQGDAPPQLEDEEPAFPHTDLAKLDDMINRPRWVVPVLPKGELEVLLEAAIDLSKKGLDVKSEACQRFFRDGLTISFTKILTDEAVSGWKFEIHRCIINNTHRLVELCVAKLSQDWFPLLELLAMALNPHCKFHIYNGTRPCESVSSSVQLPEDELFARSPDPRSPKGWLVDLLNKFGTLNGFQILHDRFINGSALNVQIIAALIKPFGQCYEFLTLHTVKKYFLPIIEMVPQFLENLTDEELKKEAKNEAKNDALSMIIKSLKNLASRVPGQEETVKNLEIFRLKMILRLLQISSFNGKMNALNEVNKVISSVSYYTHRHGNPEEEEWLTAERMAEWIQQNNILSIVLRDSLHQPQYVEKLEKILRFVIKEKALTLQDLDNIWAAQAGKHEAIVKNVHDLLAKLAWDFSPEQLDHLFDCFKASWTNASKKQREKLLELIRRLAEDDKDGVMAHKVLNLLWNLAHSDDVPVDIMDLALSAHIKILDYSCSQDRDTQKIQWIDRFIEELRTNDKWVIPALKQIREICSLFGEAPQNLSQTQRSPHVFYRHDLINQLQHNHALVTLVAENLATYMESMRLYARDHEDYDPQTVRLGSRYSHVQEVQERLNFLRFLLKDGQLWLCAPQAKQIWKCLAENAVYLCDREACFKWYSKLMGDEPDLDPDINKDFFESNVLQLDPSLLTENGMKCFERFFKAVNCREGKLVAKRRAYMMDDLELIGLDYLWRVVIQSNDDIASRAIDLLKEIYTNLGPRLQVNQVVIHEDFIQSCFDRLKASYDTLCVLDGDKDSVNCARQEAVRMVRVLTVLREYINECDSDYHEERTILPMSRAFRGKHLSFVVRFPNQGRQVDDLEVWSHTNDTIGSVRRCILNRIKANVAHTKIELFVGGELIDPADDRKLIGQLNLKDKSLITAKLTQISSNMPSSPDSSSDSSTGSPGNHGNHYSDGPNPEVESCLPGVIMSLHPRYISFLWQVADLGSSLNMPPLRDGARVLMKLMPPDSTTIEKLRAICLDHAKLGESSLSPSLDSLFFGPSASQVLYLTEVVYALLMPAGAPLADDSSDFQFHFLKSGGLPLVLSMLTRNNFLPNADMETRRGAYLNALKIAKLLLTAIGYGHVRAVAEACQPGVEGVNPMTQINQVTHDQAVVLQSALQSIPNPSSECMLRNVSVRLAQQISDEASRYMPDICVIRAIQKIIWASGCGSLQLVFSPNEEITKIYEKTNAGNEPDLEDEQVCCEALEVMTLCFALIPTALDALSKEKAWQTFIIDLLLHCHSKTVRQVAQEQFFLMCTRCCMGHRPLLFFITLLFTVLGSTARERAKHSGDYFTLLRHLLNYAYNSNINVPNAEVLLNNEIDWLKRIRDDVKRTGETGIEETILEGHLGVTKELLAFQTSEKKFHIGCEKGGANLIKELIDDFIFPASNVYLQYMRNGELPAEQAIPVCGSPPTINAGFELLVALAVGCVRNLKQIVDSLTEMYYIGTAITTCEALTEWEYLPPVGPRPPKGFVGLKNAGATCYMNSVIQQLYMIPSIRNGILAIEGTGSDVDDDMSGDEKQDNESNVDPRDDVFGYPQQFEDKPALSKTEDRKEYNIGVLRHLQVIFGHLAASRLQYYVPRGFWKQFRLWGEPVNLREQHDALEFFNSLVDSLDEALKALGHPAMLSKVLGGSFADQKICQGCPHRYECEESFTTLNVDIRNHQNLLDSLEQYVKGDLLEGANAYHCEKCNKKVDTVKRLLIKKLPPVLAIQLKRFDYDWERECAIKFNDYFEFPRELDMEPYTVAGVAKLEGDNVNPESQLIQQSEQSESETAGSTKYRLVGVLVHSGQASGGHYYSYIIQRNGGDGERNRWYKFDDGDVTECKMDDDEEMKNQCFGGEYMGEVFDHMMKRMSYRRQKRWWNAYILFYERMDTIDQDDELIRYISELAITTRPHQIIMPSAIERSVRKQNVQFMHNRMQYSMEYFQFMKKLLTCNGVYLNPPPGQDHLLPEAEEITMISIQLAARFLFTTGFHTKKVVRGSASDWYDALCILLRHSKNVRFWFAHNVLFNVSNRFSEYLLECPSAEVRGAFAKLIVFIAHFSLQDGPCPSPFASPGPSSQAYDNLSLSDHLLRAVLNLLRREVSEHGRHLQQYFNLFVMYANLGVAEKTQLLKLSVPATFMLVSLDEGPGPPIKYQYAELGKLYSVVSQLIRCCNVSSRMQSSINGNPPLPNPFGDPNLSQPIMPIQQNVADILFVRTSYVKKIIEDCSNSEETVKLLRFCCWENPQFSSTVLSELLWQVAYSYTYELRPYLDLLLQILLIEDSWQTHRIHNALKGIPDDRDGLFDTIQRSKNHYQKRAYQCIKCMVALFSNCPVAYQILQGNGDLKRKWTWAVEWLGDELERRPYTGNPQYTYNNWSPPVQSNETSNGYFLERSHSARMTLAKACELCPEEEPDDQDAPDEHESPPPEDAPLYPHSPGSQYQQNNHVHGQPYTGPAAHHMNNPQRTGQRAQENYEGSEEVSPPQTKDQ", "length": 2554, "header": "sp|Q93008-1|USP9X_HUMAN Isoform 1 of Probable ubiquitin carboxyl-terminal hydrolase FAF-X OS=Homo sapiens OX=9606 GN=USP9X PE=1 SV=4 CANONICAL=Q93008-1" }, "isoforms": [ { "isoform_ac": "A0A994J4K9-1", "url": "", "sequence": { "sequence": "PEQLDHLFDCFKASWTNASKKQREKLLELIRRLAEDDKDGVMAHKVLNLLWNLAHSDDVPVDIMDLALSAHIKILDYSCSQSNSAKSPCVLSP", "length": 93, "header": "tr|A0A994J4K9-1|USP9X_HUMAN Computationally mapped isoform of Probable ubiquitin carboxyl-terminal hydrolase FAF-X OS=Homo sapiens OX=9606 GN=USP9X PE=1 SV=1 CANONICAL=Q93008-1" }, "locus": { "chromosome": "X", "start_pos": 41152983, "end_pos": 41144591, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000704653.1", "url": "https://www.ensembl.org/id/ENST00000704653.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000515978.1", "url": "https://www.ensembl.org/id/ENSP00000515978.1" } ] } }, { "isoform_ac": "A0A994J4R6-1", "url": "", "sequence": { "sequence": "MTATTRGSPVGGNDNQGQAPDGQSQPPLQQNQTSSPDSSNENSPATPPDEQGQGDAPPQLEDEEPAFPHTDLAKLDDMINRPRWVVPVLPKGELEVLLEAAIDLSKKGLDVKSEACQRFFRDGLTISFTKILTDEAVSGWKFEIHRCIINNTHRLVELCVAKLSQDWFPLLELLAMALNPHCKFHIYNGTRPCESVSSSVQLPEDELFARSPDPRSPKGWLVDLLNKFGTLNGFQILHDRFINGSALNVQIIAALIKPFGQCYEFLTLHTVKKYFLPIIEMVPQFLENLTDEELKKEAKNEAKNDALSMIIKSLKNLASRVPGQEETVKNLEIFRLKMILRLLQISSFNGKMNALNEVNKVISSVSYYTHRHGNPEEEEWLTAERMAEWIQQNNILSIVLRDSLHQPQYVEKLEKILRFVIKEKALTLQDLDNIWAAQAGKHEAIVKNVHDLLAKLAWDFSPEQLDHLFDCFKASWTNASKKQREKLLELIRRLAEDDKDGVMAHKVLNLLWNLAHSDDVPVDIMDLALSAHIKILDYSCSQDRDTQKIQWIDRFIEELRTNDKWVIPALKQIREICSLFGEAPQNLSSSRFSQTQRSPHVFYRHDLINQLQHNHALVTLVAENLATYMESMRLYARDHEDYDPQTVRLGSRYSHVQEVQERLNFLRFLLKDGQLWLCAPQAKQIWKCLAENAVYLCDREACFKWYSKLMGDEPDLDPDINKDFFESNVLQLDPSLLTENGMKCFERFFKAVNCREGKLVAKRRAYMMDDLELIGLDYLWRVVIQSNDDIASRAIDLLKEIYTNLGPRLQVNQVVIHEDFIQSCFDRLKASYDTLCVLDGDKDSVNCARQEAVRMVRVLTVLREYINECDSDYHEERTILPMSRAFRGKHLSFVVRFPNQGRQVDDLEVWSHTNDTIGSVRRCILNRIKANVAHTKIELFVGGELIDPADDRKLIGQLNLKDKSLITAKLTQISSNMPSSPDSSSDSSTGSPGNHGNHYSDGPNPEVESCLPGVIMSLHPRYISFLWQVADLGSSLNMPPLRDGARVLMKLMPPDSTTIEKLRAICLDHAKLGESSLSPSLDSLFFGPSASQVLYLTEVVYALLMPAGAPLADDSSDFQFHFLKSGGLPLVLSMLTRNNFLPNADMETRRGAYLNALKIAKLLLTAIGYGHVRAVAEACQPGVEGVNPMTQINQVTHDQAVVLQSALQSIPNPSSECMLRNVSVRLAQQISDEASRYMPDICVIRAIQKIIWASGCGSLQLVFSPNEEITKIYEKTNAGNEPDLEDEQVCCEALEVMTLCFALIPTALDALSKEKAWQTFIIDLLLHCHSKTVRQVAQEQFFLMCTRCCMGHRPLLFFITLLFTVLGSTARERAKHSGDYFTLLRHLLNYAYNSNINVPNAEVLLNNEIDWLKRIRDDVKRTGETGIEETILEGHLGVTKELLAFQTSEKKFHIGCEKGGANLIKELIDDFIFPASNVYLQYMRNGELPAEQAIPVCGSPPTINAGFELLVALAVGCVRNLKQIVDSLTEMYYIGTAITTCEALTEWEYLPPVGPRPPKGFVGLKNAGATCYMNSVIQQLYMIPSIRNGILAIEGTGSDVDDDMSGDEKQDNESNVDPRDDVFGYPQQFEDKPALSKTEDRKEYNIGVLRHLQVIFGHLAASRLQYYVPRGFWKQFRLWGEPVNLREQHDALEFFNSLVDSLDEALKALGHPAMLSKVLGGSFADQKICQGCPHRYECEESFTTLNVDIRNHQNLLDSLEQYVKGDLLEGANAYHCEKCNKKVDTVKRLLIKKLPPVLAIQLKRFDYDWERECAIKFNDYFEFPRELDMEPYTVAGVAKLEGDNVNPESQLIQQSEQSESETAGSTKYRLVGVLVHSGQASGGHYYSYIIQRNGGDGERNRWYKFDDGDVTECKMDDDEEMKNQCFGGEYMGEVFDHMMKRMSYRRQKRWWNAYILFYERMDTIDQDDELIRYISELAITTRPHQIIMPSAIERSVRKQNVQFMHNRMQYSMEYFQFMKKLLTCNGVYLNPPPGQDHLLPEAEEITMISIQLAARFLFTTGFHTKKVVRGSASDWYDALCILLRHSKNVRFWFAHNVLFNVSNRFSEYLLECPSAEVRGAFAKLIVFIAHFSLQDGPCPSPFASPGPSSQAYDNLSLSDHLLRAVLNLLRREVSEHGRHLQQYFNLFVMYANLGVAEKTQLLKLSVPATFMLVSLDEGPGPPIKYQYAELGKLYSVVSQLIRCCNVSSRMQSSINGNPPLPNPFGDPNLSQPIMPIQQNVADILFVRTSYVKKIIEDCSNSEETVKLLRFCCWENPQFSSTVLSELLWQVAYSYTYELRPYLDLLLQILLIEDSWQTHRIHNALKGIPDDRDGLFDTIQRSKNHYQKRAYQCIKCMVALFSNCPVAYQILQGNGDLKRKWTWAVEWLGDELERRPYTGNPQYTYNNWSPPVQSNETSNGYFLERSHSARMTLAKACELCPEEVKKATSVQQIEMEESKEPDDQDAPDEHESPPPEDAPLYPHSPGSQYQQNNHVHGQPYTGPAAHHMNNPQRTGQRAQENYEGSEEVSPPQTKDQ", "length": 2575, "header": "tr|A0A994J4R6-1|USP9X_HUMAN Computationally mapped isoform of Probable ubiquitin carboxyl-terminal hydrolase FAF-X OS=Homo sapiens OX=9606 GN=USP9X PE=1 SV=1 CANONICAL=Q93008-1" }, "locus": { "chromosome": "X", "start_pos": 41232521, "end_pos": 41123629, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000703987.1", "url": "https://www.ensembl.org/id/ENST00000703987.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000515604.1", "url": "https://www.ensembl.org/id/ENSP00000515604.1" } ] } }, { "isoform_ac": "A0A994J4T3-1", "url": "", "sequence": { "sequence": "MTATTRGSPVGGNDNQGQAPDGQSQPPLQQNQTSSPDSSNENSPATPPDEQGQGDAPPQLEDEEPAFPHTDLAKLDDMINRPRWVVPVLPKGELEVLLEAAIDLSKKGLDVKSEACQRFFRDGLTISFTKILTDEAVSGWKFEIHRCIINNTHRLVELCVAKLSQDWFPLLELLAMALNPHCKFHIYNGTRPCESVSSSVQLPEDELFARSPDPRSPKGWLVDLLNKFGTLNGFQILHDRFINGSALNVQIIAALIKPFGQCYEFLTLHTVKKYFLPIIEMVPQFLENLTDEELKKEAKNEAKNDALSMIIKSLKNLASRVPGQEETVKNLEIFRLKMILRLLQISSFNGKMNALNEVNKVISSVSYYTHRHGNPEEEEWLTAERMAAGKHEAIVKNVHDLLAKLAWDFSPEQLDHLFDCFKASWTNASKKQREKLLELIRRLAEDDKDGVMAHKVLNLLWNLAHSDDVPVDIMDLALSAHIKILDYSCSQDRDTQKIQWIDRFIEELRTNDKWVIPALKQIREICSLFGEAPQNLSQTQRSPHVFYRHDLINQLQHNHALVTLVAENLATYMESMRLYARDHEDYDPQTVRLGSRYSHVQEVQERLNFLRFLLKDGQLWLCAPQAKQIWKCLAENAVYLCDREACFKWYSKLMGDEPDLDPDINKDFFESNVLQLDPSLLTENGMKCFERFFKAVNCREGKLVAKRRAYMMDDLELIGLDYLWRVVIQSNDDIASRAIDLLKEIYTNLGPRLQVNQVVIHEDFIQSCFDRLKASYDTLCVLDGDKDSVNCARQEAVRMVRVLTVLREYINECDSDYHEERTILPMSRAFRGKHLSFVVRFPNQGRQVDDLEVWSHTNDTIGSVRRCILNRIKANVAHTKIELFVGGELIDPADDRKLIGQLNLKDKSLITAKLTQISSNMPSSPDSSSDSSTGSPGNHGNHYSDGPNPEVESCLPGVIMSLHPRYISFLWQVADLGSSLNMPPLRDGARVLMKLMPPDSTTIEKLRAICLDHAKLGESSLSPSLDSLFFGPSASQVLYLTEVVYALLMPAGAPLADDSSDFQFHFLKSGGLPLVLSMLTRNNFLPNADMETRRGAYLNALKIAKLLLTAIGYGHVRAVAEACQPGVEGVNPMTQINQVTHDQAVVLQSALQSIPNPSSECMLRNVSVRLAQQISDEASRYMPDICVIRAIQKIIWASGCGSLQLVFSPNEEITKIYEKTNAGNEPDLEDEQVCCEALEVMTLCFALIPTALDALSKEKAWQTFIIDLLLHCHSKTVRQVAQEQFFLMCTRCCMGHRPLLFFITLLFTVLGSTARERAKHSGDYFTLLRHLLNYAYNSNINVPNAEVLLNNEIDWLKRIRDDVKRTGETGIEETILEGHLGVTKELLAFQTSEKKFHIGCEKGGANLIKELIDDFIFPASNVYLQYMRNGELPAEQAIPVCGSPPTINAGFELLVALAVGCVRNLKQIVDSLTEMYYIGTAITTCEALTEWEYLPPVGPRPPKGFVGLKNAGATCYMNSVIQQLYMIPSIRNGILAIEGTGSDVDDDMSGDEKQDNESNVDPRDDVFGYPQQFEDKPALSKTEDRKEYNIGVLRHLQVIFGHLAASRLQYYVPRGFWKQFRLWGEPVNLREQHDALEFFNSLVDSLDEALKALGHPAMLSKVLGGSFADQKICQGCPHRYECEESFTTLNVDIRNHQNLLDSLEQYVKGDLLEGANAYHCEKCNKKVDTVKRLLIKKLPPVLAIQLKRFDYDWERECAIKFNDYFEFPRELDMEPYTVAGVAKLEGDNVNPESQLIQQSEQSESETAGSTKYRLVGVLVHSGQASGGHYYSYIIQRNGGDGERNRWYKFDDGDVTECKMDDDEEMKNQCFGGEYMGEVFDHMMKRMSYRRQKRWWNAYILFYERMDTIDQDDELIRYISELAITTRPHQIIMPSAIERSVRKQNVQFMHNRMQYSMEYFQFMKKLLTCNGVYLNPPPGQDHLLPEAEEITMISIQLAARFLFTTGFHTKKVVRGSASDWYDALCILLRHSKNVRFWFAHNVLFNVSNRFSEYLLECPSAEVRGAFAKLIVFIAHFSLQDGPCPSPFASPGPSSQAYDNLSLSDHLLRAVLNLLRREVSEHGRHLQQYFNLFVMYANLGVAEKTQLLKLSVPATFMLVSLDEGPGPPIKYQYAELGKLYSVVSQLIRCCNVSSRMQSSINGNPPLPNPFGDPNLSQPIMPIQQNVADILFVRTSYVKKIIEDCSNSEETVKLLRFCCWENPQFSSTVLSELLWQVAYSYTYELRPYLDLLLQILLIEDSWQTHRIHNALKGIPDDRDGLFDTIQRSKNHYQKRAYQCIKCMVALFSNCPVAYQILQGNGDLKRKWTWAVEWLGDELERRPYTGNPQYTYNNWSPPVQSNETSNGYFLERSHSARMTLAKACELCPEEEPDDQDAPDEHESPPPEDAPLYPHSPGSQYQQNNHVHGQPYTGPAAHHMNNPQRTGQRAQENYEGSEEVSPPQTKDQ", "length": 2503, "header": "tr|A0A994J4T3-1|USP9X_HUMAN Computationally mapped isoform of Probable ubiquitin carboxyl-terminal hydrolase FAF-X OS=Homo sapiens OX=9606 GN=USP9X PE=1 SV=1 CANONICAL=Q93008-1" }, "locus": { "chromosome": "X", "start_pos": 41232521, "end_pos": 41123629, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000704651.1", "url": "https://www.ensembl.org/id/ENST00000704651.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000515976.1", "url": "https://www.ensembl.org/id/ENSP00000515976.1" } ] } }, { "isoform_ac": "A0A994J4T8-1", "url": "", "sequence": { "sequence": "DDVKRTGETGIEETILEGHLGVTKELLAFQTSEKKFHIGCEKGGANLIKELIDDFIFPASNVYLQYMRNGELPAEQAIPVCGSPPTINAGFELLVALAVGCVRNLKQIVDSLTEMYYIGTAITTCEALTEWEYLPPVGPRPPKGFVGLKNAGATCYMNSVIQQLYMIPSIRNGILAIEGTGSDVDDDMSGDEKQDNESNVDPRDDVFGYPQQFEDKPALSKTEDRKEYNIGVLRHLQVIFGHLAASRLQYYVPRGFWKQFRLIP", "length": 264, "header": "tr|A0A994J4T8-1|A0A994J4T8_HUMAN Computationally mapped isoform of Ubiquitin specific peptidase 9 X-linked OS=Homo sapiens OX=9606 GN=USP9X PE=1 SV=1 CANONICAL=Q93008-1" }, "locus": { "chromosome": "X", "start_pos": 41215908, "end_pos": 41197364, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000704656.1", "url": "https://www.ensembl.org/id/ENST00000704656.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000515981.1", "url": "https://www.ensembl.org/id/ENSP00000515981.1" } ] } }, { "isoform_ac": "A0A994J583-1", "url": "", "sequence": { "sequence": "MTATTRGSPVGGNDNQGQAPDGQSQPPLQQNQTSSPDSSNENSPATPPDEQGQGDAPPQLEDEEPAFPHTDLAKLDDMINRPRWVVPVLPKGELEVLLEAAIDLSKKGLDVKSEACQRFFRDGLTISFTKILTDEAVSGWKFEIHRCIINNTHRLVELCVAKLSQDWFPLLELLAMALNPHCKFHIYNGTRPCESVSSSVQLPEDELFARSPDPRSPKGWLVDLLNKFGTLNGFQILHDRFINGSALNVQIIAALIKPFGQCYEFLTLHTVKKYFLPIIEMVPQFLENLTDEELKKEAKNEAKNDALSMIIKSLKNLASRVPGQEETVKNLEIFRLKMILRLLQISSFNGKMNALNEVNKVISSVSYYTHRHGNPEEEEWLTAERMAEWIQQNNILSIVLRDSLHQPQYVEKLEKILRFVIKEKALTLQDLDNIWAAQAGKHEAIVKNVHDLLAKLAWDFSPEQLDHLFDCFKASWTNASKKQREKLLELIRRLAEDDKDGVMAHKVLNLLWNLAHSDDVPVDIMDLALSAHIKILDYSCSQDRDTQKIQWIDRFIEELRTNDKWVIPALKQIREICSLFGEAPQNLSQTQRSPHVFYRHDLINQLQHNHALVTLVAENLATYMESMRLYARDHEDYDPQTVRLGSRYSHVQEVQERLNFLRFLLKDGQLWLCAPQAKQIWKCLAENAVYLCDREACFKWYSKLMGDEPDLDPDINKDFFESNVLQLDPSLLTENGMKCFERFFKAVNCREGKLVAKRRAYMMDDLELIGLDYLWRVVIQSNDDIASRAIDLLKEIYTNLGPRLQVNQVVIHEDFIQSCFDRLKASYDTLCVLDGDKDSVNCARQEAVRMVRVLTVLREYINECDSDYHEERTILPMSRAFRGKHLSFVVRFPNQGRQVDDLEVWSHTNDTIGSVRRCILNRIKANVAHTKIELFVGGELIDPADDRKLIGQLNLKDKSLITAKLTQISSNMPSSPDSSSDSSTGSPGNHGNHYSDGPNPEVESCLPGVIMSLHPRYISFLWQVADLGSSLNMPPLRDGARVLMKLMPPDSTTIEKLRAICLDHAKLGESSLSPSLDSLFFGPSASQVLYLTEVVYALLMPAGAPLADDSSDFQFHFLKSGGLPLVLSMLTRNNFLPNADMETRRGAYLNALKIAKLLLTAIGYGHVRAVAEACQPGVEGVNPMTQINQVTHDQAVVLQSALQSIPNPSSECMLRNVSVRLAQQISDENNHVHGQPYTGPAAHHMNNPQRTGQRAQENYEGSEEVSPPQTKDQ", "length": 1273, "header": "tr|A0A994J583-1|USP9X_HUMAN Computationally mapped isoform of Probable ubiquitin carboxyl-terminal hydrolase FAF-X OS=Homo sapiens OX=9606 GN=USP9X PE=1 SV=1 CANONICAL=Q93008-1" }, "locus": { "chromosome": "X", "start_pos": 41232521, "end_pos": 41123629, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000704649.1", "url": "https://www.ensembl.org/id/ENST00000704649.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000515974.1", "url": "https://www.ensembl.org/id/ENSP00000515974.1" } ] } }, { "isoform_ac": "A0A994J588-1", "url": "", "sequence": { "sequence": "TNAGNEPDLEDEQVCCEALEVMTLCFALIPTALDALSKEKAWQTFIIDLLLHCHSKTVRQVAQEQFFLMCTRCCMGHRPLLFFITLLFTVLGSTARERAKHSGDYFTLLRHLLNYAYNSNINVPNAEVLLNNEIDWLKRIRDDVKRTGETGIEETILEGHLGVTKELLAFQTSEKKFHIGCEKGGANLIKELIDDFIFPASNVYLQYMRNGELPAEQAIPVCGSPPTINAGFELLVALAVGCVRNLKQIVDSLTEMYYIGTAITTCEALTEWEYLPPVGPRPPKGFVGLKNAGATCYMNSVIQQLYMIPSIRNGILAIEGTGSDVDDDMSGDEKQDNESNVDPRDDVFGYPQQFEDKPALSKTEDRKEYNIGVLRHLQVIFGHLAASRLQYYVPRGFWKQFRIF", "length": 404, "header": "tr|A0A994J588-1|USP9X_HUMAN Computationally mapped isoform of Probable ubiquitin carboxyl-terminal hydrolase FAF-X OS=Homo sapiens OX=9606 GN=USP9X PE=1 SV=1 CANONICAL=Q93008-1" }, "locus": { "chromosome": "X", "start_pos": 41210562, "end_pos": 41189309, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000704655.1", "url": "https://www.ensembl.org/id/ENST00000704655.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000515980.1", "url": "https://www.ensembl.org/id/ENSP00000515980.1" } ] } }, { "isoform_ac": "A0A994J6S4-1", "url": "", "sequence": { "sequence": "MTATTRGSPVGGNDNQGQAPDGQSQPPLQQNQTSSPDSSNENSPATPPDEQGQGDAPPQLEDEEPAFPHTDLAKLDDMINRPRWVVPVLPKGELEVLLEAAIDLSKKGLDVKSEACQRFFRDGLTISFTKILTDEAVSGWKFEIHRCIINNTHRLVELCVAKLSQDWFPLLELLAMALNPHCKFHIYNGTRPCESVSSSVQLPEDELFARSPDPRSPKGWLVDLLNKFGTLNGFQILHDRFINGSALNVQIIAALIKPFGQCYEFLTLHTVKKYFLPIIEMVPQFLENLTDEELKKEAKNEAKNDALSMIIKSLKNLASRVPGQEETVKNLEIFRLKMILRLLQISSFNGKMNALNEVNKVISSVSYYTHRHGNPEEEEWLTAERMAEWIQQNNILSIVLRDSLHQPQYVEKLEKILRFVIKEKALTLQDLDNIWAAQAGKHEAIVKNVHDLLAKLAWDFSPEQLDHLFDCFKASWTNASKKQREKLLELIRRLAEDDKDGVMAHKVLNLLWNLAHSDDVPVDIMDLALSAHIKILDYSCSQDRDTQKIQWIDRFIEELRTNDKWVIPALKQIREICSLFGEAPQNLSSSRFSQTQRSPHVFYRHDLINQLQHNHALVTLVAENLATYMESMRLYARDHEDYDPQTVRLGSRYSHVQEVQERLNFLRFLLKDGQLWLCAPQAKQIWKCLAENAVYLCDREACFKWYSKLMGDEPDLDPDINKDFFESNVLQLDPSLLTENGMKCFERFFKAVNCREGKLVAKRRAYMMDDLELIGLDYLWRVVIQSNDDIASRAIDLLKEIYTNLGPRLQVNQVVIHEDFIQSCFDRLKASYDTLCVLDGDKDSVNCARQEAVRMVRVLTVLREYINECDSDYHEERTILPMSRAFRGKHLSFVVRFPNQGRQVDDLEVWSHTNDTIGSVRRCILNRIKANVAHTKIELFVGGELIDPADDRKLIGQLNLKDKSLITAKLTQISSNMPSSPDSSSDSSTGSPGNHGNHYSDGPNPEVESCLPGVIMSLHPRYISFLWQVADLGSSLNMPPLRDGARVLMKLMPPDSTTIEKLRAICLDHAKLGESSLSPSLDSLFFGPSASQVLYLTEVVYALLMPAGAPLADDSSDFQFHFLKSGGLPLVLSMLTRNNFLPNADMETRRGAYLNALKIAKLLLTAIGYGHVRAVAEACQPGVEGVNPMTQINQVTHDQAVVLQSALQSIPNPSSECMLRNVSVRLAQQISDEASRYMPDICVIRAIQKIIWASGCGSLQLVFSPNEEITKIYEKTNAGNEPDLEDEQVCCEALEVMTLCFALIPTALDALSKEKAWQTFIIDLLLHCHSKTVRQVAQEQFFLMCTRCCMGHRPLLFFITLLFTVLGSTARERAKHSGDYFTLLRHLLNYAYNSNINVPNAEVLLNNEIDWLKRIRDDVKRTGETGIEETILEGHLGVTKELLAFQTSEKKFHIGCEKGGANLIKELIDDFIFPASNVYLQYMRNGELPAEQAIPVCGSPPTINAGFELLVALAVGCVRNLKQIVDSLTEMYYIGTAITTCEALTEWEYLPPVGPRPPKGFVGLKNAGATCYMNSVIQQLYMIPSIRNGILAIEGTGSDVDDDMSGDEKQDNESNVDPRDDVFGYPQQFEDKPALSKTEDRKEYNIGVLRHLQVIFGHLAASRLQYYVPRGFWKQFRLWGEPVNLREQHDALEFFNSLVDSLDEALKALGHPAMLSKVLGGSFADQKICQGCPHRYECEESFTTLNVDIRNHQNLLDSLEQYVKGDLLEGANAYHCEKCNKKVDTVKRLLIKKLPPVLAIQLKRFDYDWERECAIKFNDYFEFPRELDMEPYTVAGVAKLEGDNVNPESQLIQQSEQSESETAGSTKYRLVGVLVHSGQASGGHYYSYIIQRNGGDGERNRWYKFDDGDVTECKMDDDEEMKNQCFGGEYMGEVFDHMMKRMSYRRQKRWWNAYILFYERMDTIDQDDELIRYISELAITTRPHQIIMPSAIERSVRKQNVQFMHNRMQYSMEYFQFMKKLLTCNGVYLNPPPGQDHLLPEAEEITMISIQLAARFLFTTGFHTKKVVRGSASDWYDALCILLRHSKNVRFWFAHNVLFNVSNRFSEYLLECPSAEVRGAFAKLIVFIAHFSLQDGPCPSPFASPGPSSQAYDNLSLSDHLLRAVLNLLRREVSEHGRHLQQYFNLFVMYANLGVAEKTQLLKLSVPATFMLVSLDEGPGPPIKYQYAELGKLYSVVSQLIRCCNVSSRMQSSINGNPPLPNPFGDPNLSQPIMPIQQNVADILFVRTSYVKKIIEDCSNSEETVKLLRFCCWENPQFSSTVLSELLWQVAYSYTYELRPYLDLLLQILLIEDSWQTHRIHNALKGIPDDRDGLFDTIQRSKNHYQKRAYQCIKCMVALFSNCPVAYQILQGNGDLKRKWTWAVEWLGDELERRPYTGNPQYTYNNWSPPVQSNETSNGYFLERSHSARMTLAKACELCPEEEPDDQDAPDEHESPPPEDAPLYPHSPGSQYQQNNHVHGQPYTGPAAHHMNNPQRTGQRAQENYEGSEEVSPPQTKDQ", "length": 2559, "header": "tr|A0A994J6S4-1|USP9X_HUMAN Computationally mapped isoform of Probable ubiquitin carboxyl-terminal hydrolase FAF-X OS=Homo sapiens OX=9606 GN=USP9X PE=1 SV=1 CANONICAL=Q93008-1" }, "locus": { "chromosome": "X", "start_pos": 41232521, "end_pos": 41123629, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000703986.1", "url": "https://www.ensembl.org/id/ENST00000703986.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000515603.1", "url": "https://www.ensembl.org/id/ENSP00000515603.1" } ] } }, { "isoform_ac": "A0A994J766-1", "url": "", "sequence": { "sequence": "XYISFLWQVADLGSSLNMPPLRDGARVLMKLMPPDSTTIEKLRAICLDHAKLGESSLSPSLDSLFFGPSASQVLYLTEVVYALLMPAGAPLADDSSDFQFHFLKSGGLPLVLSMLTRNNFLPNADMETRRGAYLNALKIAKLLLTAIGYGHVRAVAEACQPGVEGVNPMTQINQVTHDQAVVLQSALQSIPNPSSECMLRNVSVRLAQQISDEASRYMPDICVIRAIQKIIWASGCGSLQLVFSPNEEITKIYEKTNAGNEPDLEDEQVCCEALEVMTLCFALIPTALDALSKEKAWQTFIIDLLLHCHSKTVRQVAQEQFFLMCTRCCMGHRPLLFFITLLFTVLGSTARERAKHSGDYFTLLRHLLNYAYNSNINVPNAEVLLNNEIDWLKRIRDDVKRTGETGIEETILEGHLGVTKELLAFQTSEKKFHIGCEKGGANLIKELIDDFIFPASNVYLQYMRNGELPAEQAIPVCGSPPTINAGFELLVALAVGCVRNLKQIVDSLTEMYYIGTAITTCEALTEWEYLPPVGPRPPKGFVGLKNAGATCYMNSVIQQLYMIPSIRNGILAIEGTGSDVDDDMSGDEKQDNESNVDPRDDVFGYPQQFEDKPALSKTEDRKEYNIGVLRHLQVIFGHLAASRLQYYVPRGFWKQFRLWGEPVNLREQHDALEFFNSLVDSLDEALKALGHPAMLSKVLGGSFADQKICQGCPHRYECEESFTTLNVDIRNHQNLLDSLEQYVKGDLLEGANAYHCEKCNKKVDTVKRLLIKKLPPVLAIQLKRFDYDWERECAIKFNDYFEFPRELDMEPYTVAGVAKLEGDNVNPESQLIQQSEQSESETAGSTKYRLVGVLVHSGQASGGHYYSYIIQRNGGDGERNRWYKFDDGDVTECKMDDDEEMKNQCFGGEYMGEVFDHMMKRMSYRRQKRWWNAYILFYERMDTIDQDDELIRYISELAITTRPHQIIMPSAIERSVRKQNVQFMHNRMQYSMEYFQFMKKLLTCNGVYLNPPPGQDHLLPEAEEITMISIQLAARFLFTTGFHTKKVVRGSASDWYDALCILLRHSKNVRFWFAHNVLFNVSNRFSEYLLECPSAEVRGAFAKLIVFIAHFSLQDGPCPSPFASPGPSSQAYDNLSLSDHLLRAVLNLLRREVSEHGRHLQQYFNLFVMYANLGVAEKTQLLKLSVPATFMLVSLDEGPGPPIKYQYAELGNPPLPNPFGDPNLSQPIMPIQQNVADILFVRTSYVKKIIEDCSNSEETVKLLRFCCWENPQFSSTVLSELLWQVAYSYTYELRPYLDLLLQILLIEDSWQTHRIHNALKGIPDDRDGLFDTIQRSKNHYQKRAYQCIKCMVALFSNCPVAYQILQGNGDLKRKWTWAVEWLGDELERRPYTGNPQYTYNNWSPPVQSNETSNGYFLERSHSARMTLAKACELCPEEEPDDQDAPDEHESPPPEDAPLYPHSPGSQYQQNNHVHGQPYTGPAAHHMNNPQRTGQRAQENYEGSEEVSPPQTKDQ", "length": 1514, "header": "tr|A0A994J766-1|USP9X_HUMAN Computationally mapped isoform of Probable ubiquitin carboxyl-terminal hydrolase FAF-X OS=Homo sapiens OX=9606 GN=USP9X PE=1 SV=1 CANONICAL=Q93008-1" }, "locus": { "chromosome": "X", "start_pos": 41232522, "end_pos": 41171857, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000704654.1", "url": "https://www.ensembl.org/id/ENST00000704654.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000515979.1", "url": "https://www.ensembl.org/id/ENSP00000515979.1" } ] } }, { "isoform_ac": "A0A994J7K1-1", "url": "", "sequence": { "sequence": "XPFGQCYEFLTLHTVKKYFLPIIEMVPQFLENLTDEELKKEAKNEAKNDALSMIIKSLKNLASRVPGQEETVKNLEIFRLKMILRLLQISSFNGKMNALNEVNKVISSVSYYTHRHGNPEEEEWLTAERMAEWIQQNNILSIVLRDSLHQPQYVEKLEKILRFVIKEKALTLQDLDNIWAAQAGKHEAIVKNVHDLLAKLAWDFSPEQLDHLFDCFKASWTNASKKQREKLLELIRRLAEDDKDGVMAHKVLNLLWNLAHSDDVPVDIMDLALSAHIKILDYSCSQDRDTQKIQWIDRFIEELRTNDKWVIPALKQIREICSLFGEAPQNLSQTQRSPHVFYRHDLINQLQHNHALVTLVAENLATYMESMRLYARDHEDYDPQTVRLGSRYSHVQEVQERLNFLRFLLKDGQLWLCAPQAKQIWKCLAENAVYLCDREACFKWYSKLMGDEPDLDPDINKDFFESNVLQLDPSLLTENGMKCFERFFKAVNCREGKLVAKRRAYMMDDLELIGLDYLWRVVIQSNDDIASRAIDLLKEIYTNLGPRLQVNQVVIHEDFIQSCFDRLKASYDTLCVLDGDKDSVNCARQEAVRMVRVLTVLREYINECDSDYHEERTILPMSRAFRGKHLSFVVRFPNQGRQVDDLEVWSHTNDTIGSVRRCILNRIKANVAHTKIELFVGGELIDPADDRKLIGQLNLKDKSLITAKLTQISSNMPSSPDSSSDSSTGSPGNHGNHYSDGPNPEVESCLPGVIMSLHPRYISFLWQVADLGSSLNMPPLRDGARVLMKLMPPGSLCLVNACWCTSG", "length": 807, "header": "tr|A0A994J7K1-1|USP9X_HUMAN Computationally mapped isoform of Probable ubiquitin carboxyl-terminal hydrolase FAF-X OS=Homo sapiens OX=9606 GN=USP9X PE=1 SV=1 CANONICAL=Q93008-1" }, "locus": { "chromosome": "X", "start_pos": 41184439, "end_pos": 41140966, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000704652.1", "url": "https://www.ensembl.org/id/ENST00000704652.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000515977.1", "url": "https://www.ensembl.org/id/ENSP00000515977.1" } ] } }, { "isoform_ac": "Q93008-1", "url": "", "sequence": { "sequence": "MTATTRGSPVGGNDNQGQAPDGQSQPPLQQNQTSSPDSSNENSPATPPDEQGQGDAPPQLEDEEPAFPHTDLAKLDDMINRPRWVVPVLPKGELEVLLEAAIDLSKKGLDVKSEACQRFFRDGLTISFTKILTDEAVSGWKFEIHRCIINNTHRLVELCVAKLSQDWFPLLELLAMALNPHCKFHIYNGTRPCESVSSSVQLPEDELFARSPDPRSPKGWLVDLLNKFGTLNGFQILHDRFINGSALNVQIIAALIKPFGQCYEFLTLHTVKKYFLPIIEMVPQFLENLTDEELKKEAKNEAKNDALSMIIKSLKNLASRVPGQEETVKNLEIFRLKMILRLLQISSFNGKMNALNEVNKVISSVSYYTHRHGNPEEEEWLTAERMAEWIQQNNILSIVLRDSLHQPQYVEKLEKILRFVIKEKALTLQDLDNIWAAQAGKHEAIVKNVHDLLAKLAWDFSPEQLDHLFDCFKASWTNASKKQREKLLELIRRLAEDDKDGVMAHKVLNLLWNLAHSDDVPVDIMDLALSAHIKILDYSCSQDRDTQKIQWIDRFIEELRTNDKWVIPALKQIREICSLFGEAPQNLSQTQRSPHVFYRHDLINQLQHNHALVTLVAENLATYMESMRLYARDHEDYDPQTVRLGSRYSHVQEVQERLNFLRFLLKDGQLWLCAPQAKQIWKCLAENAVYLCDREACFKWYSKLMGDEPDLDPDINKDFFESNVLQLDPSLLTENGMKCFERFFKAVNCREGKLVAKRRAYMMDDLELIGLDYLWRVVIQSNDDIASRAIDLLKEIYTNLGPRLQVNQVVIHEDFIQSCFDRLKASYDTLCVLDGDKDSVNCARQEAVRMVRVLTVLREYINECDSDYHEERTILPMSRAFRGKHLSFVVRFPNQGRQVDDLEVWSHTNDTIGSVRRCILNRIKANVAHTKIELFVGGELIDPADDRKLIGQLNLKDKSLITAKLTQISSNMPSSPDSSSDSSTGSPGNHGNHYSDGPNPEVESCLPGVIMSLHPRYISFLWQVADLGSSLNMPPLRDGARVLMKLMPPDSTTIEKLRAICLDHAKLGESSLSPSLDSLFFGPSASQVLYLTEVVYALLMPAGAPLADDSSDFQFHFLKSGGLPLVLSMLTRNNFLPNADMETRRGAYLNALKIAKLLLTAIGYGHVRAVAEACQPGVEGVNPMTQINQVTHDQAVVLQSALQSIPNPSSECMLRNVSVRLAQQISDEASRYMPDICVIRAIQKIIWASGCGSLQLVFSPNEEITKIYEKTNAGNEPDLEDEQVCCEALEVMTLCFALIPTALDALSKEKAWQTFIIDLLLHCHSKTVRQVAQEQFFLMCTRCCMGHRPLLFFITLLFTVLGSTARERAKHSGDYFTLLRHLLNYAYNSNINVPNAEVLLNNEIDWLKRIRDDVKRTGETGIEETILEGHLGVTKELLAFQTSEKKFHIGCEKGGANLIKELIDDFIFPASNVYLQYMRNGELPAEQAIPVCGSPPTINAGFELLVALAVGCVRNLKQIVDSLTEMYYIGTAITTCEALTEWEYLPPVGPRPPKGFVGLKNAGATCYMNSVIQQLYMIPSIRNGILAIEGTGSDVDDDMSGDEKQDNESNVDPRDDVFGYPQQFEDKPALSKTEDRKEYNIGVLRHLQVIFGHLAASRLQYYVPRGFWKQFRLWGEPVNLREQHDALEFFNSLVDSLDEALKALGHPAMLSKVLGGSFADQKICQGCPHRYECEESFTTLNVDIRNHQNLLDSLEQYVKGDLLEGANAYHCEKCNKKVDTVKRLLIKKLPPVLAIQLKRFDYDWERECAIKFNDYFEFPRELDMEPYTVAGVAKLEGDNVNPESQLIQQSEQSESETAGSTKYRLVGVLVHSGQASGGHYYSYIIQRNGGDGERNRWYKFDDGDVTECKMDDDEEMKNQCFGGEYMGEVFDHMMKRMSYRRQKRWWNAYILFYERMDTIDQDDELIRYISELAITTRPHQIIMPSAIERSVRKQNVQFMHNRMQYSMEYFQFMKKLLTCNGVYLNPPPGQDHLLPEAEEITMISIQLAARFLFTTGFHTKKVVRGSASDWYDALCILLRHSKNVRFWFAHNVLFNVSNRFSEYLLECPSAEVRGAFAKLIVFIAHFSLQDGPCPSPFASPGPSSQAYDNLSLSDHLLRAVLNLLRREVSEHGRHLQQYFNLFVMYANLGVAEKTQLLKLSVPATFMLVSLDEGPGPPIKYQYAELGKLYSVVSQLIRCCNVSSRMQSSINGNPPLPNPFGDPNLSQPIMPIQQNVADILFVRTSYVKKIIEDCSNSEETVKLLRFCCWENPQFSSTVLSELLWQVAYSYTYELRPYLDLLLQILLIEDSWQTHRIHNALKGIPDDRDGLFDTIQRSKNHYQKRAYQCIKCMVALFSNCPVAYQILQGNGDLKRKWTWAVEWLGDELERRPYTGNPQYTYNNWSPPVQSNETSNGYFLERSHSARMTLAKACELCPEEEPDDQDAPDEHESPPPEDAPLYPHSPGSQYQQNNHVHGQPYTGPAAHHMNNPQRTGQRAQENYEGSEEVSPPQTKDQ", "length": 2554, "header": "sp|Q93008-1|USP9X_HUMAN Isoform 1 of Probable ubiquitin carboxyl-terminal hydrolase FAF-X OS=Homo sapiens OX=9606 GN=USP9X PE=1 SV=4 CANONICAL=Q93008-1" }, "locus": { "chromosome": "X", "start_pos": 41232521, "end_pos": 41123629, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000704650.1", "url": "https://www.ensembl.org/id/ENST00000704650.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000515975.1", "url": "https://www.ensembl.org/id/ENSP00000515975.1" } ] } }, { "isoform_ac": "Q93008-3", "url": "", "sequence": { "sequence": "MTATTRGSPVGGNDNQGQAPDGQSQPPLQQNQTSSPDSSNENSPATPPDEQGQGDAPPQLEDEEPAFPHTDLAKLDDMINRPRWVVPVLPKGELEVLLEAAIDLSKKGLDVKSEACQRFFRDGLTISFTKILTDEAVSGWKFEIHRCIINNTHRLVELCVAKLSQDWFPLLELLAMALNPHCKFHIYNGTRPCESVSSSVQLPEDELFARSPDPRSPKGWLVDLLNKFGTLNGFQILHDRFINGSALNVQIIAALIKPFGQCYEFLTLHTVKKYFLPIIEMVPQFLENLTDEELKKEAKNEAKNDALSMIIKSLKNLASRVPGQEETVKNLEIFRLKMILRLLQISSFNGKMNALNEVNKVISSVSYYTHRHGNPEEEEWLTAERMAEWIQQNNILSIVLRDSLHQPQYVEKLEKILRFVIKEKALTLQDLDNIWAAQAGKHEAIVKNVHDLLAKLAWDFSPEQLDHLFDCFKASWTNASKKQREKLLELIRRLAEDDKDGVMAHKVLNLLWNLAHSDDVPVDIMDLALSAHIKILDYSCSQDRDTQKIQWIDRFIEELRTNDKWVIPALKQIREICSLFGEAPQNLSQTQRSPHVFYRHDLINQLQHNHALVTLVAENLATYMESMRLYARDHEDYDPQTVRLGSRYSHVQEVQERLNFLRFLLKDGQLWLCAPQAKQIWKCLAENAVYLCDREACFKWYSKLMGDEPDLDPDINKDFFESNVLQLDPSLLTENGMKCFERFFKAVNCREGKLVAKRRAYMMDDLELIGLDYLWRVVIQSNDDIASRAIDLLKEIYTNLGPRLQVNQVVIHEDFIQSCFDRLKASYDTLCVLDGDKDSVNCARQEAVRMVRVLTVLREYINECDSDYHEERTILPMSRAFRGKHLSFVVRFPNQGRQVDDLEVWSHTNDTIGSVRRCILNRIKANVAHTKIELFVGGELIDPADDRKLIGQLNLKDKSLITAKLTQISSNMPSSPDSSSDSSTGSPGNHGNHYSDGPNPEVESCLPGVIMSLHPRYISFLWQVADLGSSLNMPPLRDGARVLMKLMPPDSTTIEKLRAICLDHAKLGESSLSPSLDSLFFGPSASQVLYLTEVVYALLMPAGAPLADDSSDFQFHFLKSGGLPLVLSMLTRNNFLPNADMETRRGAYLNALKIAKLLLTAIGYGHVRAVAEACQPGVEGVNPMTQINQVTHDQAVVLQSALQSIPNPSSECMLRNVSVRLAQQISDEASRYMPDICVIRAIQKIIWASGCGSLQLVFSPNEEITKIYEKTNAGNEPDLEDEQVCCEALEVMTLCFALIPTALDALSKEKAWQTFIIDLLLHCHSKTVRQVAQEQFFLMCTRCCMGHRPLLFFITLLFTVLGSTARERAKHSGDYFTLLRHLLNYAYNSNINVPNAEVLLNNEIDWLKRIRDDVKRTGETGIEETILEGHLGVTKELLAFQTSEKKFHIGCEKGGANLIKELIDDFIFPASNVYLQYMRNGELPAEQAIPVCGSPPTINAGFELLVALAVGCVRNLKQIVDSLTEMYYIGTAITTCEALTEWEYLPPVGPRPPKGFVGLKNAGATCYMNSVIQQLYMIPSIRNGILAIEGTGSDVDDDMSGDEKQDNESNVDPRDDVFGYPQQFEDKPALSKTEDRKEYNIGVLRHLQVIFGHLAASRLQYYVPRGFWKQFRLWGEPVNLREQHDALEFFNSLVDSLDEALKALGHPAMLSKVLGGSFADQKICQGCPHRYECEESFTTLNVDIRNHQNLLDSLEQYVKGDLLEGANAYHCEKCNKKVDTVKRLLIKKLPPVLAIQLKRFDYDWERECAIKFNDYFEFPRELDMEPYTVAGVAKLEGDNVNPESQLIQQSEQSESETAGSTKYRLVGVLVHSGQASGGHYYSYIIQRNGGDGERNRWYKFDDGDVTECKMDDDEEMKNQCFGGEYMGEVFDHMMKRMSYRRQKRWWNAYILFYERMDTIDQDDELIRYISELAITTRPHQIIMPSAIERSVRKQNVQFMHNRMQYSMEYFQFMKKLLTCNGVYLNPPPGQDHLLPEAEEITMISIQLAARFLFTTGFHTKKVVRGSASDWYDALCILLRHSKNVRFWFAHNVLFNVSNRFSEYLLECPSAEVRGAFAKLIVFIAHFSLQDGPCPSPFASPGPSSQAYDNLSLSDHLLRAVLNLLRREVSEHGRHLQQYFNLFVMYANLGVAEKTQLLKLSVPATFMLVSLDEGPGPPIKYQYAELGKLYSVVSQLIRCCNVSSRMQSSINGNPPLPNPFGDPNLSQPIMPIQQNVADILFVRTSYVKKIIEDCSNSEETVKLLRFCCWENPQFSSTVLSELLWQVAYSYTYELRPYLDLLLQILLIEDSWQTHRIHNALKGIPDDRDGLFDTIQRSKNHYQKRAYQCIKCMVALFSNCPVAYQILQGNGDLKRKWTWAVEWLGDELERRPYTGNPQYTYNNWSPPVQSNETSNGYFLERSHSARMTLAKACELCPEEVKKATSVQQIEMEESKEPDDQDAPDEHESPPPEDAPLYPHSPGSQYQQNNHVHGQPYTGPAAHHMNNPQRTGQRAQENYEGSEEVSPPQTKDQ", "length": 2570, "header": "sp|Q93008-3|USP9X_HUMAN Isoform 3 of Probable ubiquitin carboxyl-terminal hydrolase FAF-X OS=Homo sapiens OX=9606 GN=USP9X PE=1 SV=4 CANONICAL=Q93008-1" }, "locus": { "chromosome": "X", "start_pos": 41232521, "end_pos": 41123629, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000324545.9", "url": "https://www.ensembl.org/id/ENST00000324545.9" }, { "database": "Ensembl Peptide", "id": "ENSP00000316357.6", "url": "https://www.ensembl.org/id/ENSP00000316357.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "Q93008", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=Q93008" }, { "id": "35138101", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35138101" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "34725712", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34725712" }, { "id": "37217939", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37217939" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "28510447", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28510447" } ] } ], "phosphorylation": [ { "start_pos": 1593, "end_pos": 1593, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q93008", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q93008" }, { "database": "PubMed", "id": "18452278", "url": "https://glygen.org/publication/PubMed/18452278" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" }, { "database": "phospho.ELM", "id": "Q93008", "url": "http://phospho.elm.eu.org/byAccession/Q93008.html" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ], "site_lbl": "Ser1593" }, { "start_pos": 1600, "end_pos": 1600, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "18691976", "url": "https://glygen.org/publication/PubMed/18691976" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "PubMed", "id": "21406692", "url": "https://glygen.org/publication/PubMed/21406692" }, { "database": "PubMed", "id": "19690332", "url": "https://glygen.org/publication/PubMed/19690332" }, { "database": "iPTMnet", "id": "Q93008", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q93008" }, { "database": "PubMed", "id": "17322306", "url": "https://glygen.org/publication/PubMed/17322306" }, { "database": "PubMed", "id": "18452278", "url": "https://glygen.org/publication/PubMed/18452278" }, { "database": "PubMed", "id": "18767875", "url": "https://glygen.org/publication/PubMed/18767875" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" } ], "site_lbl": "Ser1600" }, { "start_pos": 1609, "end_pos": 1609, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q93008", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q93008" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ], "site_lbl": "Ser1609" }, { "start_pos": 2402, "end_pos": 2402, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q93008", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q93008" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Tyr2402" }, { "start_pos": 2443, "end_pos": 2443, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "PubMed", "id": "21406692", "url": "https://glygen.org/publication/PubMed/21406692" }, { "database": "PubMed", "id": "17693683", "url": "https://glygen.org/publication/PubMed/17693683" }, { "database": "iPTMnet", "id": "Q93008", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q93008" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" } ], "site_lbl": "Ser2443" }, { "start_pos": 2448, "end_pos": 2448, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q93008", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q93008" }, { "database": "PubMed", "id": "18691976", "url": "https://glygen.org/publication/PubMed/18691976" } ], "site_lbl": "Ser2448" }, { "start_pos": 2540, "end_pos": 2540, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008" }, { "database": "PubMed", "id": "15592455", "url": "https://glygen.org/publication/PubMed/15592455" }, { "database": "iPTMnet", "id": "Q93008", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q93008" } ], "site_lbl": "Tyr2540" }, { "start_pos": 2547, "end_pos": 2547, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "PubMed", "id": "16964243", "url": "https://glygen.org/publication/PubMed/16964243" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "Q93008", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q93008" }, { "database": "PubMed", "id": "18452278", "url": "https://glygen.org/publication/PubMed/18452278" }, { "database": "PubMed", "id": "18691976", "url": "https://glygen.org/publication/PubMed/18691976" }, { "database": "PubMed", "id": "19413330", "url": "https://glygen.org/publication/PubMed/19413330" }, { "database": "PubMed", "id": "19664994", "url": "https://glygen.org/publication/PubMed/19664994" } ], "site_lbl": "Ser2547" }, { "start_pos": 2551, "end_pos": 2551, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "iPTMnet", "id": "Q93008", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q93008" } ], "site_lbl": "Thr2551" }, { "start_pos": 313, "end_pos": 313, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q93008", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q93008" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Ser313" }, { "start_pos": 588, "end_pos": 588, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "Q93008", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q93008" } ], "site_lbl": "Ser588" }, { "start_pos": 590, "end_pos": 590, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "Q93008", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q93008" }, { "database": "PubMed", "id": "18691976", "url": "https://glygen.org/publication/PubMed/18691976" } ], "site_lbl": "Thr590" }, { "start_pos": 701, "end_pos": 701, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q93008", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q93008" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Tyr701" }, { "start_pos": 702, "end_pos": 702, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q93008", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q93008" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Ser702" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Identification and characterization of the human orthologue of yeast Pex14p.", "journal": "Molecular and cellular biology", "date": "1999", "authors": "Will GK, Soukupova M, Hong X, Erdmann KS, Kiel JA, Dodt G, Kunau WH, Erdmann R", "evidence": [ { "database": "Reactome", "id": "R-HSA-9033241", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9033241" } ], "reference": [ { "type": "PubMed", "id": "10022913", "url": "https://glygen.org/publication/PubMed/10022913" } ] }, { "title": "Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1999", "authors": "Lammich S, Kojro E, Postina R, Gilbert S, Pfeiffer R, Jasionowski M, Haass C, Fahrenholz F", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "10097139", "url": "https://glygen.org/publication/PubMed/10097139" } ] }, { "title": "A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras.", "journal": "Genes & development", "date": "1999", "authors": "Kretzschmar M, Doody J, Timokhina I, Massague J", "evidence": [ { "database": "Reactome", "id": "R-HSA-2173795", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2173795" } ], "reference": [ { "type": "PubMed", "id": "10197981", "url": "https://glygen.org/publication/PubMed/10197981" } ] }, { "title": "A Smad transcriptional corepressor.", "journal": "Cell", "date": "1999", "authors": "Wotton D, Lo RS, Lee S, Massague J", "evidence": [ { "database": "Reactome", "id": "R-HSA-2173795", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2173795" } ], "reference": [ { "type": "PubMed", "id": "10199400", "url": "https://glygen.org/publication/PubMed/10199400" } ] }, { "title": "Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions.", "journal": "Nature genetics", "date": "1999", "authors": "Engelender S, Kaminsky Z, Guo X, Sharp AH, Amaravi RK, Kleiderlein JJ, Margolis RL, Troncoso JC, Lanahan AA, Worley PF, Dawson VL, Dawson TM, Ross CA", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "10319874", "url": "https://glygen.org/publication/PubMed/10319874" } ] }, { "title": "A stop-codon mutation in the BRI 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Mol. Genet.", "date": "1996", "authors": "Affara N.A., Jones M.H., Brown G.M., Furlong R.A., Khwaja O., Chalmers I.J., Burkin H.", "evidence": [ { "database": "UniProtKB", "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008" } ], "reference": [ { "type": "PubMed", "id": "8922996", "url": "https://glygen.org/publication/PubMed/8922996" } ] }, { "title": "Multiple PEX genes are required for proper subcellular distribution and stability of Pex5p, the PTS1 receptor: evidence that PTS1 protein import is mediated by a cycling receptor.", "journal": "The Journal of cell biology", "date": "1996", "authors": "Dodt G, Gould SJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-9033241", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9033241" } ], "reference": [ { "type": "PubMed", "id": "8991089", "url": "https://glygen.org/publication/PubMed/8991089" } ] }, { "title": "Prolactin-derived amyloid in the aging pituitary gland.", "journal": "The American journal of pathology", "date": "1997", "authors": "Westermark P, Eriksson L, Engstrom U, Enestrom S, Sletten K", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "9006323", "url": "https://glygen.org/publication/PubMed/9006323" } ] }, { "title": "Kerato-epithelin mutations in four 5q31-linked corneal dystrophies.", "journal": "Nature genetics", "date": "1997", "authors": "Munier FL, Korvatska E, Djemai A, Le Paslier D, Zografos L, Pescia G, Schorderet DF", "evidence": [ { "database": "Reactome", "id": "R-HSA-977225", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-977225" } ], "reference": [ { "type": "PubMed", "id": "9054935", "url": "https://glygen.org/publication/PubMed/9054935" } ] }, { "title": "Human PEX7 encodes the peroxisomal PTS2 receptor and is responsible for rhizomelic chondrodysplasia punctata.", "journal": "Nature genetics", "date": "1997", "authors": "Braverman N, Steel G, Obie C, Moser A, Moser H, Gould SJ, Valle D", "evidence": [ { "database": "Reactome", "id": "R-HSA-9033241", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9033241" } ], "reference": [ { "type": "PubMed", "id": "9090381", "url": "https://glygen.org/publication/PubMed/9090381" } ] }, { "title": "Rhizomelic chondrodysplasia punctata is a peroxisomal protein targeting disease caused by a non-functional PTS2 receptor.", "journal": "Nature genetics", "date": "1997", "authors": "Motley AM, Hettema EH, Hogenhout EM, Brites P, ten Asbroek AL, Wijburg FA, Baas F, Heijmans HS, Tabak HF, Wanders RJ, Distel B", "evidence": [ { "database": "Reactome", "id": "R-HSA-9033241", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9033241" } ], "reference": [ { "type": "PubMed", "id": "9090382", "url": "https://glygen.org/publication/PubMed/9090382" } ] }, { "title": "Rhizomelic chondrodysplasia punctata is caused by deficiency of human PEX7, a homologue of the yeast PTS2 receptor.", 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"length": 2778 }, "evidence": [ { "id": "Q93008", "url": "https://omabrowser.org/oma/group/Q93008/", "database": "OMA" } ], "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "P70398-1", "protein_name": "Probable ubiquitin carboxyl-terminal hydrolase FAF-X", "gene_name": "Usp9x", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTATTRGSPVGGNDNQGQAPDGQSQPPLQQNQTSSPDSSNENSPATPPDEQGQGDAPPQIEDEEPAFPHTDLAKLDDMINRPRWVVPVLPKGELEVLLEAAIDLSKKGLDVKSEACQRFFRDGLTISFTKILTDEAVSGWKFEIHRCIINNTHRLVELCVAKLAQDWFPLLELLAMALNPHCKFHIYNGTRPCESVSSSVQLPEDELFARSPDPRSPKGWLVDLLNKFGTLNGFQILHDRFINGSALNVQIIAALIKPFGQCYEFLTLHTVKKYFLPIIEMVPQFLENLTDEELKKEAKNEAKNDALSMIIKSLKNLASRVPGQEETVKNLEIFRLKMILRLLQISSFNGKMNALNEVNKVISSVSYYTHRHGSSEDEEWLTAERMAEWIQQNNILSIVLRDSLHQPQYVEKLEKILRFVIKEKALTLQDLDNIWAAQAGKHEAIVKNVHDLLAKLAWDFSPEQLDHLFDCFKASWTNASKKQREKLLELIRRLAEDDKDGVMAHKVLNLLWNLAHSDDVPVDIMDLALSAHIKILDYSCSQDRDTQKIQWIDRFIEELRTNDKWVIPALKQIREICSLFGEAPQNLSQSQRSPHVFYRHDLINQLQHNHALVTLVAENLATYMESMRMYGRDNEDYDPQTVRLGSRYSHVQEVQERLNFLRFLLKDGQLWLCAPQAKQIWKCLAENAVYLCDREACFKWYSKLMGDEPDLDPDINKDFFESNVLQLDPSLLTENGMKCFERFFKAVNCREGKLVAKRRAYMMDDLELIGLDYLWRVVIQSNDDIACRAIDLLKEIYTNLGPRLQVNQVVIHEDFIQSCFDRLKASYDTLCVLDGDKDSINCARQEAVRMVRVLTVLREYINECDSDYHEERTILPMSRAFRGKHLSFIVRFPNQGRQVDDLEVWSHTNDTIGSVRRCILNRIKANVAHTKIELFVGGELIDPGDDRKLIGQLNLKDKSLITAKLTQISSNMPSSPDSSSDSSTGSPGNHGNHYSDGPNPEVESCLPGVIMSLHPRYISFLWQVADLGSSLNMPPLRDGARVLMKLMPPDSTTIEKLRAICLDHAKLGESSLSPSLDSLFFGPSASQVLYLTEVVYALLMPAGAPLTDDSSDFQFHFLKSGGLPLVLSMLTRNNFLPNADMETRRGAYLNALKIAKLLLTAIGYGHVRAVAEACQPGVEGVNPMTSVNQVTHDQAVVLQSALQSIPNPSSECMLRNVSVRLAQQISDEASRYMPDICVIRAIQKIIWTSGCGGLQLVFSPNEEVTKIYEKTNAGNEPDLEDEQVCCEALEVMTLCFALIPTALDALSKEKAWQTFIIDLLLHCHSKTVRQVAQEQFFLMCTRCCMGHRPLLFFITLLFTVLGSTARERAKHSGDYFTLLRHLLNYAYNSNINVPNAEVLLNNEIDWLKRIRDDVKRTGETGVEETILEGHLGVTKELLAFQTPEKKFHIGCEKGGANLIKELIDDFIFPASNVYLQYMRNGELPAEQAIPVCGSPATINAGFELLVALAVGCVRNLKQIVDSLTEMYYIGTAITTCEALTEWEYLPPVGPRPPKGFVGLKNAGATCYMNSVIQQLYMIPSIRNGILAIEGTGSDVDDDMSGDEKQDNESNVDPRDDVFGYPQQFEDKPPLSKTEDRKEYNIGVLRHLQVIFGHLAASRLQYYVPRGFWKQFRLWGEPVNLREQHDALEFFNSLVDSLDEALKALGHPAMLSKVLGGSFADQKICQGCPHRYECEESFTTLNVDIRNHQNLLDSLEQYVKGDLLEGANAYHCEKCNKKVDTVKRLLIKKLPPVLAIQLKRFDYDWERECAIKFNDYFEFPRELDMEPYTVAGVAKLEGDNVNPESQLIQQNEQSESEKAGSTKYRLVGVLVHSGQASGGHYYSYIIQRNGGDGEKNRWYKFDDGDVTECKMDDDEEMKNQCFGGEYMGEVFDHMMKRMSYRRQKRWWNAYILFYERMDTIGHDDEVIRYISEIAITTRPHQIVMPSAIERSVRKQNVQFMHNRMQYSLEYFQFMKKLLTCNGVYLNPPPGQDHLSPEAEEITMISIQLAARFLFTTGFHTKKIVRGSASDWYDALCILLRHSKNVRFWFAHNVLFNVSNRFSEYLLECPSAEVRGAFAKLIVFIAHFSLQDGPCPSPFASPGPSSQAYDNLSLSDHLLRAVLNLLRREVSEHGRHLQQYFNLFVMYANLGVAEKTQLLKLSVPATFMLVSLDEGPGPPIKYQYAELGKLYSVVSQLIRCCNVSSRMQSSINGNPSLPNPFGDPNLSQPIMPIQQNVVDILFVRTSYVKKIIEDCSNSDETVKLLRFCCWENPQFSSTVLSELLWQVAYSYTYELRPYLDLLLQILLIEDSWQTHRIHNALKGIPDDRDGLFDTIQRSKNHYQKRAYQCIKCMVALFSSCPVAYQILQGNGDLKRKWTWAVEWLGDELERRPYTGNPQYTYNNWSPPVQSNETSNGYFLERSHSARMTLAKACELCPEEEPDDQDAPDEHESPPPEDAPLYPHSPGSQYQQNNHVHGQPYTGPAAHHMNNPQRTGQRAQENYEGGEEVSPPQTKGSVKCTY", "length": 2559 }, "evidence": [ { "id": "45228227", "url": "http://www.informatics.jax.org/homology/45228227", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 7, "go_terms": [ { "name": "co-SMAD binding", "id": "GO:0070410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070410", "evidence": [ { "database": "UniProtKB", "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008" } ], "pmid": "" }, { "name": "cysteine-type endopeptidase activity", "id": "GO:0004197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004197", "evidence": [ { "database": "UniProtKB", "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008" } ], "pmid": "" }, { "name": "cysteine-type peptidase activity", "id": "GO:0008234", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008234", "evidence": [ { "database": "UniProtKB", "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008" } ], "pmid": "" }, { "name": "cysteine-type deubiquitinase activity", "id": "GO:0004843", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004843", "evidence": [ { "database": "UniProtKB", "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008" } ], "pmid": "" }, { "name": "K63-linked deubiquitinase activity", "id": "GO:0061578", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061578", "evidence": [ { "database": "UniProtKB", "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008" } ], "pmid": "" }, { "name": "K48-linked deubiquitinase activity", "id": "GO:1990380", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990380", "evidence": [ { "database": "UniProtKB", "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008" } ], "pmid": "" }, { "name": "deubiquitinase activity", "id": "GO:0101005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0101005", "evidence": [ { "database": "UniProtKB", "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 24, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008" } ], "pmid": "" }, { "name": "chromosome segregation", "id": "GO:0007059", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007059", "evidence": [ { "database": "UniProtKB", "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008" } ], "pmid": "" }, { "name": "cell migration", "id": "GO:0016477", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016477", "evidence": [ { "database": "UniProtKB", "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008" } ], "pmid": "" }, { "name": "protein deubiquitination", "id": "GO:0016579", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016579", "evidence": [ { "database": "UniProtKB", "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008" } ], "pmid": "" }, { "name": "positive regulation of protein binding", "id": "GO:0032092", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032092", "evidence": [ { "database": "UniProtKB", "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008" } ], "pmid": "" }, { "name": "cell division", "id": "GO:0051301", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "evidence": [ { "database": "UniProtKB", "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008" } ], "pmid": "" }, { "name": "protein K63-linked deubiquitination", "id": "GO:0070536", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070536", "evidence": [ { "database": "UniProtKB", "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008" } ], "pmid": "" }, { "name": "amyloid fibril formation", "id": "GO:1990000", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990000", "evidence": [ { "database": "UniProtKB", "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008" } ], "pmid": "" }, { "name": "neuron migration", "id": "GO:0001764", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001764", "evidence": [ { "database": "UniProtKB", "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008" } ], "pmid": "" }, { "name": "transforming growth factor beta receptor signaling pathway", "id": "GO:0007179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007179", "evidence": [ { "database": "UniProtKB", "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008" } ], "pmid": "" }, { "name": "protein stabilization", "id": "GO:0050821", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050821", "evidence": [ { "database": "UniProtKB", "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008" } ], "pmid": "" }, { "name": "BMP signaling pathway", "id": "GO:0030509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030509", "evidence": [ { "database": "UniProtKB", "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008" } ], "pmid": "" }, { "name": "protein ubiquitination", "id": "GO:0016567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "evidence": [ { "database": "UniProtKB", "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008" } ], "pmid": "" }, { "name": "regulation of circadian rhythm", "id": "GO:0042752", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042752", "evidence": [ { "database": "UniProtKB", "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008" } ], "pmid": "" }, { "name": "rhythmic process", "id": "GO:0048511", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048511", "evidence": [ { "database": "UniProtKB", "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008" } ], "pmid": "" }, { "name": "protein localization", "id": "GO:0008104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008104", "evidence": [ { "database": "UniProtKB", "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008" } ], "pmid": "" }, { "name": "negative regulation of proteasomal ubiquitin-dependent protein catabolic process", "id": "GO:0032435", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032435", "evidence": [ { "database": "UniProtKB", "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008" } ], "pmid": "" }, { "name": "axon extension", "id": "GO:0048675", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048675", "evidence": [ { "database": "UniProtKB", "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008" } ], "pmid": "" }, { "name": "positive regulation of DNA demethylation", "id": "GO:1901537", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901537", "evidence": [ { "database": "UniProtKB", "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008" } ], "pmid": "" }, { "name": "female gamete generation", "id": "GO:0007292", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007292", "evidence": [ { "database": "UniProtKB", "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008" } ], "pmid": "" }, { "name": "monoubiquitinated protein deubiquitination", "id": "GO:0035520", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035520", "evidence": [ { "database": "UniProtKB", "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008" } ], "pmid": "" }, { "name": "protein deubiquitination involved in ubiquitin-dependent protein catabolic process", "id": "GO:0071947", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071947", "evidence": [ { "database": "UniProtKB", "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008" } ], "pmid": "" }, { "name": "positive regulation of TORC2 signaling", "id": "GO:1904515", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904515", "evidence": [ { "database": "UniProtKB", "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008" } ], "pmid": "" }, { "name": "protein import into peroxisome matrix, receptor recycling", "id": "GO:0016562", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016562", "evidence": [ { "database": "UniProtKB", "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008" } ], "pmid": "" }, { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008" } ], "pmid": "" }, { "name": "cilium", "id": "GO:0005929", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "evidence": [ { "database": "UniProtKB", "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008" } ], "pmid": "" }, { "name": "growth cone", "id": "GO:0030426", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030426", "evidence": [ { "database": "UniProtKB", "id": "Q93008", "url": "https://www.uniprot.org/uniprot/Q93008" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1216, "end_pos": 1218, "annotation": "n_glycosylation_sequon" }, { "start_pos": 150, "end_pos": 152, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1607, "end_pos": 1609, "annotation": "n_glycosylation_sequon" }, { "start_pos": 188, "end_pos": 190, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2095, "end_pos": 2097, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2149, "end_pos": 2151, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2240, "end_pos": 2242, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2263, "end_pos": 2265, "annotation": "n_glycosylation_sequon" }, { "start_pos": 243, "end_pos": 245, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2441, "end_pos": 2443, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2449, "end_pos": 2451, "annotation": "n_glycosylation_sequon" }, { "start_pos": 288, "end_pos": 290, "annotation": "n_glycosylation_sequon" }, { "start_pos": 31, "end_pos": 33, "annotation": "n_glycosylation_sequon" }, { "start_pos": 478, "end_pos": 480, "annotation": "n_glycosylation_sequon" }, { "start_pos": 586, "end_pos": 588, "annotation": "n_glycosylation_sequon" }, { "start_pos": 909, "end_pos": 911, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-HSA-5660752", "name": "USP9X deubiquitinates Ub-SNCA", "equation": "", "summary": "The deubiquitinase USP9X binds and deubiquitinates alpha-synuclein (SNCA) in vitro and in vivo, showing co-accumulation with SNCA in Lewy Bodies. Knockdown of USP9X expression in conditions of proteolytic inhibition leads to the accumulation of monoubiquitinated SNCA and increases the aggregation of SNCA into toxic inclusions, strengthening the connection between monoubiquitination, inclusion formation, and toxicity of SNCA. USP9X cytosolic levels are lower in Diffuse Lewy Body disease and Parkinson's Disease tissues, which may contribute to the accumulation and aggregation of monoubiquitinated SNCA (Rott et al. 2011).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q93008-1" ], "evidence": [ { "id": "R-HSA-5660752", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5660752" } ] }, { "id": "R-HSA-5661157", "name": "USP9X binds Ub-SNCA", "equation": "", "summary": "The deubiquitinase USP9X binds and deubiquitinates alpha-synuclein (SNCA) in vitro and in vivo, showing co-accumulation with SNCA in Lewy Bodies. Knockdown of USP9X expression in conditions of proteolytic inhibition leads to the accumulation of monoubiquitinated SNCA and increases the aggregation of SNCA into toxic inclusions, strengthening the connection between monoubiquitination, inclusion formation, and toxicity of SNCA. USP9X cytosolic levels are lower in Diffuse Lewy Body disease and Parkinson's Disease tissues, which may contribute to the accumulation and aggregation of monoubiquitinated SNCA (Rott et al. 2011).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q93008-1" ], "evidence": [ { "id": "R-HSA-5661157", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5661157" } ] }, { "id": "R-HSA-5661161", "name": "USP9X:SNCA dissociates", "equation": "", "summary": "Following the removal of ubiquitin, SNCA is released by USP9X (Rott et al. 2011).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q93008-1" ], "evidence": [ { "id": "R-HSA-5661161", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5661161" } ] }, { "id": "R-HSA-870437", "name": "USP9X (FAM) deubiquitinates SMAD4", "equation": "", "summary": "USP9X (FAM) deubiquitinates SMAD4, thereby opposing the negative regulatory activity of TRIM33 (Ectodermin) (Dupont et al. 2009).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-HSA-170862", "R-HSA-870499" ], "enzyme_list": [ "Q93008-1" ], "evidence": [ { "id": "R-HSA-870437", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-870437" } ] }, { "id": "R-HSA-870479", "name": "USP9X (FAM) binds to ubiquitinated SMAD4", "equation": "", "summary": "In the cytosol, a ubiquitin hydrolase USP9X (FAM) binds to ubiquitinated SMAD4 (Dupont et al. 2009).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q93008-1" ], "evidence": [ { "id": "R-HSA-870479", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-870479" } ] }, { "id": "R-HSA-8853503", "name": "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin", "equation": "", "summary": "The RPS27A precursor protein contains the ribosomal protein L40 and ubiquitin (RPS27A residues 1 to 76) which are released by proteolysis. Any of the proteases UCHL3, USP7, or USP9X can catalyze the proteolysis reaction (Larsen et al. 1998, Grou et al. 2015).", "cellular_location": "cytosol", "input_participant_list": [ "R-HSA-8853524" ], "output_participant_list": [ "R-HSA-72363", "R-HSA-939205" ], "enzyme_list": [ "P15374-1", "Q93009-1", "Q93008-1" ], "evidence": [ { "id": "R-HSA-8853503", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8853503" } ] }, { "id": "R-HSA-8853514", "name": "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin", "equation": "", "summary": "The UBA52 precursor protein contains the ribosomal protein L40 and ubiquitin (UBA52 residues 1 to 76) which are released by proteolysis. Any of the proteases UCHL3, USP7, or USP9X can catalyze the proteolysis reaction (Larsen et al. 1998, Grou et al. 2015).", "cellular_location": "cytosol", "input_participant_list": [ "R-HSA-8853517" ], "output_participant_list": [ "R-HSA-72476", "R-HSA-939203" ], "enzyme_list": [ "P15374-1", "Q93009-1", "Q93008-1" ], "evidence": [ { "id": "R-HSA-8853514", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8853514" } ] }, { "id": "R-HSA-9018766", "name": "RHOU binds effectors at the plasma membrane", "equation": "", "summary": "In its active GTP bound form, RHOU binds the following effectors:
ARHGAP30 (Naji et al. 2011; protein with GAP activity)
ARHGAP31 (Naji et al. 2011; protein with GAP activity)
GRB2 (Zhang et al. 2011; Bagci et al. 2020: weak binding)
ITSN2 (Gubar et al. 2020)
NCK2 (Saras et al. 2004; Bagci et al. 2020)
PAK1 (Tao et al. 2001; Shutes et al. 2004; Saras et al. 2004; Bagci et al. 2020)
PAK4 (Dart et al. 2015)
PAR6 (Brady et al. 2009)
PIK3R1 (Chuang et al. 2007; Bagci et al. 2020; protein with GAP activity)
PTK2B (Ruusala and Aspenstr\u00f6m 2008)


The following candidate RHOU effectors were identified in the high throughput screen by Bagci et al. 2020:
ARHGEF6 (Bagci et al. 2020)
ARHGEF7 (Bagci et al. 2020)
CDC42 (Bagci et al. 2020)
CLTC (Bagci et al. 2020)
DEPDC1B (Bagci et al. 2020; protein with GAP activity)
DLG5 (Bagci et al. 2020)
DST (Bagci et al. 2020)
EPHA2 (Bagci et al. 2020)
GIT1 (Bagci et al. 2020)
GIT2 (Bagci et al. 2020)
HGS (Bagci et al. 2020)
IQGAP1 (Bagci et al. 2020)
MYO6 (Bagci et al. 2020)
NCK1 (Bagci et al. 2020)
PAK2 (Bagci et al. 2020)
PAK3 (Bagci et al. 2020)
PIK3R2 (Bagci et al. 2020; protein with GAP activity)
PEAK1 (Bagci et al. 2020)
SPTAN1 (Bagci et al. 2020)
SPTBN1 (Bagci et al. 2020)
SRGAP2 (Bagci et al. 2020; protein with GAP activity)
STAM (Bagci et al. 2020)
STAM2 (Bagci et al. 2020)
TXNL1 (Bagci et al. 2020)
USP9X (Bagci et al. 2020)
VANGL1 (Bagci et al. 2020)
WDR6 (Bagci et al. 2020)
WWP2 (Bagci et al. 2020)

RHOU does not bind WASL, a component of the WIP WASP complex (Bagci et al. 2020) and also does not bind:
CCP110 (Bagci et al. 2020)
CEP97 (Bagci et al. 2020)
MAP3K21 (Bagci et al. 2020)
MYH11 (Bagci et al. 2020)
MYL12B (Bagci et al. 2020)
SH3RF1 (Bagci et al. 2020)
TPM3 (Bagci et al. 2020)
TPM4 (Bagci et al. 2020)
ZNF512B (Bagci et al. 2020)", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P60953-2", "O00308-1", "Q13153-1", "Q13177-1", "O75914-1", "O96013-1", "P29317-1", "Q14289-1", "Q93008-1" ], "evidence": [ { "id": "R-HSA-9018766", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9018766" } ] }, { "id": "R-HSA-9018794", "name": "RHOV binds effectors at the plasma membrane", "equation": "", "summary": "In its active GTP bound form, RHOV activates the following effectors:
PAK1 (Weisz Hubsman et al. 2007; Bagci et al. 2020)
PAK2 (Aronheim et al. 1998; Bagci et al. 2020)
PAK6 (Shepelev and Korobko 2012)
The functional consequences of the interaction have only been established for RHOV and PAK1 (Weisz Hubsman et a. 2007).

The following candidate RHOV effectors were identified in the high throughput screens by Aspenstr\u00f6m et al. 2004 and Bagci et al. 2020; the biological roles of these interactions have not been characterized:
ARHGEF7 (Bagci et al. 2020)
CCP110 (Bagci et al. 2020)
CDC42 (Bagci et al. 2020)
CEP97 (Bagci et al. 2020)
CLTC (Bagci et al. 2020)
DEPDC1B (Bagci et al. 2020)
DLG5 (Bagci et al. 2020)
DST (Bagci et al. 2020)
EPHA2 (Bagci et al. 2020)
GIT1 (Bagci et al. 2020)
GIT2 (Bagci et al. 2020)
IQGAP1 (Bagci et al. 2020)
MAP3K11 (Aspenstr\u00f6m et al. 2004)
MAP3K21 (Bagci et al. 2020)
MYH11 (Bagci et al. 2020)
MYL12B (Bagci et al. 2020)
MYO6 (Bagci et al. 2020)
NCK1 (Bagci et al. 2020)
NCK2 (Bagci et al. 2020);
PAK4 (Aspenstr\u00f6m et al. 2004; Bagci et al. 2020: weak interaction)
PARD6A (Aspenstr\u00f6m et al. 2004)
PARD6B (Bagci et al. 2020: weak interaction)
PEAK1 (Bagci et al. 2020)
SH3RF1 (Bagci et al. 2020)
SPTAN1 (Bagci et al. 2020)
SPTBN1 (Bagci et al. 2020)
TPM3 (Bagci et al. 2020)
TPM4 (Bagci et al. 2020)
TXNL1 (Bagci et al. 2020)
USP9X (Bagci et al. 2020)
VANGL1 (Bagci et al. 2020)
WASL (Aspenstr\u00f6m et al. 2004; Bagci et al. 2020)
WDR6 (Bagci et al. 2020)
ZNF512B (Bagci et al. 2020)

Active RHOV does not bind the following putative effector proteins which do bind active RHOU:
HGS (Bagci et al. 2020)
PAK3 (Bagci et al. 2020)
STAM (Bagci et al. 2020)
STAM2 (Bagci et al. 2020)
WWP2 (Bagci et al. 2020)", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P60953-2", "Q13153-1", "Q13177-1", "O96013-1", "Q16584-1", "P29317-1", "Q9NQU5-1", "Q93008-1", "Q7Z6J0-1" ], "evidence": [ { "id": "R-HSA-9018794", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9018794" } ] }, { "id": "R-HSA-9033478", "name": "USP9X hydrolyzes Ub:PEX5S yielding PEX5S and Ubiquitin", "equation": "", "summary": "The deubiquitinating enzyme USP9X hydrolyzes the thioester bond between the carboxyl terminus of ubiquitin and cysteine-11 of PEX5S (inferred from the large isoform of PEX5L in Grou et al. 2012). The thioester bond is unstable and appears also to be spontaneously disrupted by nucleophilic attack of small metabolites such as reduced glutathione (Grou et al. 2009).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-HSA-9033154" ], "enzyme_list": [ "Q93008-1" ], "evidence": [ { "id": "R-HSA-9033478", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9033478" } ] }, { "id": "R-HSA-9033491", "name": "USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin", "equation": "", "summary": "The deubiquitinating enzyme USP9X hydrolyzes the thioester bond between the carboxyl terminus of ubiquitin and cysteine-11 of PEX5L (Grou et al. 2012). The thioester bond is unstable and appears to be also spontaneously (non-enzymatically) disrupted by nucleophilic attack of small metabolites such as reduced glutathione (Grou et al. 2009).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-HSA-9033103" ], "enzyme_list": [ "Q93008-1" ], "evidence": [ { "id": "R-HSA-9033491", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9033491" } ] }, { "id": "R-HSA-9033509", "name": "USP9X binds Ub:PEX5L", "equation": "", "summary": "The deubiquitinating enzyme USP9X binds ubiquitinated PEX5L (ubiquitin conjugated to the large isoform of PEX5, Ub:PEX5L) and then hydrolyzes the thioester bond between the carboxyl terminus of ubiquitin and cysteine-11 of PEX5L (Grou et al. 2012).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q93008-1" ], "evidence": [ { "id": "R-HSA-9033509", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9033509" } ] }, { "id": "R-HSA-9033526", "name": "USP9X binds Ub:PEX5S", "equation": "", "summary": "The deubiquitinating enzyme USP9X binds cytosolic ubiquitinated PEX5S (Ub:PEX5S) and then hydrolyzes the thioester bond between the carboxyl terminus of ubiquitin and cysteine-11 of PEX5S (inferred from the large isoform of PEX5 in Grou et al. 2012).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q93008-1" ], "evidence": [ { "id": "R-HSA-9033526", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9033526" } ] } ], "reaction_participants": [ { "participant_id": "R-HSA-170862", "participant_name": "SMAD4 [cytosol]", "crossref": [ { "id": "Q13485", "database": "UniProt", "url": "" }, { "id": "15524", "database": "Orphanet", "url": "" }, { "id": "1MR1", "database": "PDB", "url": "" }, { "id": "5MEY", "database": "PDB", "url": "" }, { "id": "ENST00000342988", "database": "Ensembl", "url": "" }, { "id": "ENSG00000141646", "database": "Ensembl", "url": "" }, { "id": "1DD1", "database": "PDB", "url": "" }, { "id": "1YGS", "database": "PDB", "url": "" }, { "id": "ENST00000398417", "database": "Ensembl", "url": "" }, { "id": "ENSG00000141646", "database": "OpenTargets", "url": "" }, { "id": "6YIC", "database": "PDB", "url": "" }, { "id": "Q13485", "database": "PRO", "url": "" }, { "id": "1G88", "database": "PDB", "url": "" }, { "id": "5C4V", "database": "PDB", "url": "" }, { "id": "ENSP00000341551", "database": "Ensembl", "url": "" }, { "id": "ENSP00000381452", "database": "Ensembl", "url": "" }, { "id": "ENSG00000141646-SMAD4", "database": "HPA", "url": "" }, { "id": "NP_005350.1", "database": "RefSeq", "url": "" }, { "id": "HMDBP14469", "database": "HMDB Protein", "url": "" }, { "id": "1U7V", "database": "PDB", "url": "" }, { "id": "5UWU", "database": "PDB", "url": "" }, { "id": "Q13485", "database": "GeneCards", "url": "" }, { "id": "5MEZ", "database": "PDB", "url": "" }, { "id": "1U7F", "database": "PDB", "url": "" }, { "id": "Q13485", "database": "Pharos - Targets", "url": "" }, { "id": "5MF0", "database": "PDB", "url": "" } ] }, { "participant_id": "R-HSA-72363", "participant_name": "RPS27A(77-156) [cytosol]", "crossref": [ { "id": "P62979", "database": "UniProt", "url": "" }, { "id": "7WTT", "database": "PDB", "url": "" }, { "id": "5LKS", "database": "PDB", "url": "" }, { "id": "6Z6M", "database": "PDB", "url": "" }, { "id": "5FLX", "database": "PDB", "url": "" }, { "id": "6Z6L", "database": "PDB", "url": "" }, { "id": "7TQL", "database": "PDB", "url": "" }, { "id": "7WTW", "database": "PDB", "url": "" }, { "id": "6ZM7", "database": "PDB", "url": "" }, { "id": "7WTV", "database": "PDB", "url": "" }, { "id": "6ZLW", "database": "PDB", "url": "" }, { "id": "5T2C", "database": "PDB", "url": "" }, { "id": "5WVO", "database": "PDB", "url": "" }, { "id": "7WTU", "database": "PDB", "url": "" }, { "id": "6Z6N", "database": "PDB", "url": "" }, { "id": "7WU0", "database": "PDB", "url": "" }, { "id": "7WTZ", "database": "PDB", "url": "" }, { "id": "6ZMO", "database": "PDB", "url": "" }, { "id": "7WTX", "database": "PDB", "url": "" }, { "id": "6ZMI", "database": "PDB", "url": "" }, { "id": "5YDK", "database": "PDB", "url": "" }, { "id": "6DC6", "database": "PDB", "url": "" }, { "id": "6ZME", "database": "PDB", "url": "" }, { "id": "6ZMW", "database": "PDB", "url": "" }, { "id": "6FEC", "database": "PDB", "url": "" }, { "id": "6ZMT", "database": "PDB", "url": "" }, { "id": "6G18", "database": "PDB", "url": "" }, { "id": "7K5I", "database": "PDB", "url": "" }, { "id": "6OM7", "database": "PDB", "url": "" }, { "id": "3NS8", "database": "PDB", "url": "" }, { "id": "6OM0", "database": "PDB", "url": "" }, { "id": "3PHD", "database": "PDB", "url": "" }, { "id": "3NOB", "database": "PDB", "url": "" }, { "id": "7JQC", "database": "PDB", "url": "" }, { "id": "7MQA", "database": "PDB", "url": "" }, { "id": "NP_002945.1", "database": "RefSeq", "url": "" }, { "id": "6SQO", "database": "PDB", "url": "" }, { "id": "3TBL", "database": "PDB", "url": "" }, { "id": "6QZP", "database": "PDB", "url": "" }, { "id": "3PHW", "database": "PDB", "url": "" }, { "id": "NP_001170884.1", "database": "RefSeq", "url": "" }, { "id": "7MQ9", "database": "PDB", "url": "" }, { "id": "NP_001129064.1", "database": "RefSeq", "url": "" }, { "id": "7QP7", "database": "PDB", "url": "" }, { "id": "6XA1", "database": "PDB", "url": "" }, { "id": "4UG0", "database": "PDB", "url": "" }, { "id": "4R62", "database": "PDB", "url": "" }, { "id": "7QP6", "database": "PDB", "url": "" }, { "id": "6SQS", "database": "PDB", "url": "" }, { "id": "3VDZ", "database": "PDB", "url": "" }, { "id": "7OOJ", "database": "PDB", "url": "" }, { "id": "6SQR", "database": "PDB", "url": "" }, { "id": "7R4X", "database": "PDB", "url": "" }, { "id": "6YBS", "database": "PDB", "url": "" }, { "id": "5A2Q", "database": "PDB", "url": "" }, { "id": "6Y57", "database": "PDB", "url": "" }, { "id": "5AJ0", "database": "PDB", "url": "" }, { "id": "ENST00000404735", "database": "Ensembl", "url": "" }, { "id": "ENSP00000272317", "database": "Ensembl", "url": "" }, { "id": "ENSG00000143947", "database": "Ensembl", "url": "" }, { "id": "4V6X", "database": "PDB", "url": "" }, { "id": "ENSP00000383981", "database": "Ensembl", "url": "" }, { "id": "ENST00000402285", "database": "Ensembl", "url": "" }, { "id": "ENSP00000385659", "database": "Ensembl", "url": "" }, { "id": "6Y0G", "database": "PDB", "url": "" }, { "id": "ENST00000272317", "database": "Ensembl", "url": "" }, { "id": "P62979", "database": "Pharos - Targets", "url": "" }, { "id": "6KIV", "database": "PDB", "url": "" }, { "id": "2XK5", "database": "PDB", "url": "" }, { "id": "6ZXE", "database": "PDB", "url": "" }, { "id": "6KIU", "database": "PDB", "url": "" }, { "id": "2L0T", "database": "PDB", "url": "" }, { "id": "6KG6", "database": "PDB", "url": "" }, { "id": "6ZXG", "database": "PDB", "url": "" }, { "id": "6KIW", "database": "PDB", "url": "" }, { "id": "3I3T", "database": "PDB", "url": "" }, { "id": "6OLE", "database": "PDB", "url": "" }, { "id": "P62979", "database": "PRO", "url": "" }, { "id": "3AXC", "database": "PDB", "url": "" }, { "id": "6ZXF", "database": "PDB", "url": "" }, { "id": "6OLF", "database": "PDB", "url": "" }, { "id": "3N30", "database": "PDB", "url": "" }, { "id": "6OLG", "database": "PDB", "url": "" }, { "id": "3K9P", "database": "PDB", "url": "" }, { "id": "6ZXH", "database": "PDB", "url": "" }, { "id": "24875", "database": "Orphanet", "url": "" }, { "id": "6OLI", "database": "PDB", "url": "" }, { "id": "6J99", "database": "PDB", "url": "" }, { "id": "2KWU", "database": "PDB", "url": "" }, { "id": "6ZVJ", "database": "PDB", "url": "" }, { "id": "6KFP", "database": "PDB", "url": "" }, { "id": "6ZXD", "database": "PDB", "url": "" }, { "id": "2KWV", "database": "PDB", "url": "" }, { "id": "2L0F", "database": "PDB", "url": "" }, 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