{ "uniprot_canonical_ac": "Q925S8-1", "uniprot_ac": "Q925S8", "uniprot_id": "YMEL1_RAT", "mass": { "chemical_mass": 79867.0, "monoisotopic_mass": 79867.0 }, "refseq": {}, "gene_names": [ { "name": "Yme1l1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q925S8", "id": "Q925S8" } ], "protein_names": [ { "name": "ATP-dependent zinc metalloprotease YME1L1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q925S8" }, { "name": "3.4.24.-", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q925S8" }, { "name": "ATP-dependent metalloprotease FtsH1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q925S8" }, { "name": "Meg-4", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q925S8" }, { "name": "YME1-like protein 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q925S8" } ], "function": [ { "annotation": "ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region (By similarity). Plays an important role in regulating mitochondrial morphology and function by cleaving OPA1 at position S2, giving rise to a form of OPA1 that promotes maintenance of normal mitochondrial structure (By similarity). Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins (By similarity). Required for normal, constitutive degradation of PRELID1 (By similarity). Catalyzes the degradation of OMA1 in response to membrane depolarization. Required to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1) (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "Q925S8", "url": "https://www.uniprot.org/uniprot/Q925S8#function" }, { "database": "UniProtKB", "id": "O88967", "url": "https://www.uniprot.org/uniprot/O88967#function" }, { "database": "UniProtKB", "id": "Q96TA2", "url": "https://www.uniprot.org/uniprot/Q96TA2#function" } ] } ], "disease": [ { "disease_id": "DOID:0050861", "recommended_name": { "id": "DOID:0050861", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050861", "name": "colorectal adenocarcinoma", "description": "A colorectal carcinoma that derives_from epithelial cells of glandular origin." }, "synonyms": [], "evidence": [ { "id": "0050861", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0050861" } ] }, { "disease_id": "DOID:0111436", "recommended_name": { "id": "DOID:0111436", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111436", "name": "optic atrophy 11", "description": "An optic atrophy characterized by delayed psychomotor development, intellectual disability, ataxia, optic atrophy, and leukoencephalopathy consistent with mitochondrial dysfunction that has_material_basis_in homozygous or compound heterozygous mutation in the YME1L1 gene on chromosome 10p12.1." }, "synonyms": [ { "id": "DOID:0111436", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111436", "name": "OPA11", "description": "" }, { "id": "MONDO:0015011", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0015011", "name": "optic atrophy 11", "description": "Any autosomal recessive isolated optic atrophy in which the cause of the disease is a mutation in the YME1L1 gene." }, { "id": "MONDO:0015011", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0015011", "name": "OPA11", "description": "" }, { "id": "MONDO:0015011", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0015011", "name": "YME1L1 autosomal recessive isolated optic atrophy", "description": "" }, { "id": "MONDO:0015011", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0015011", "name": "autosomal recessive isolated optic atrophy caused by mutation in YME1L1", "description": "" }, { "id": "MONDO:0015011", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0015011", "name": "optic atrophy 11", "description": "" }, { "id": "MONDO:0015011", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0015011", "name": "optic atrophy type 11", "description": "" }, { "id": "MIM:617302", "resource": "MIM", "url": "https://www.omim.org/entry/617302", "name": "Optic atrophy 11", "description": "Optic atrophy 11" } ], "evidence": [ { "id": "0111436", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:0111436" } ] }, { "disease_id": "DOID:12930", "recommended_name": { "id": "DOID:12930", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:12930", "name": "dilated cardiomyopathy", "description": "An intrinsic cardiomyopathy that is characterized by an an enlarged heart and damage to the myocardium causing the heart to pump blood inefficiently." }, "synonyms": [ { "id": "DOID:12930", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:12930", "name": "primary dilated cardiomyopathy", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "dilated cardiomyopathy 1A", "description": "Familial dilated cardiomyopathy with conduction defect due to LMNA mutation is a rare familial dilated cardiomyopathy characterized by left ventricular enlargement and/or reduced systolic function preceded or accompanied by significant conduction system disease and/or arrhythmias including bradyarrhythmias, supraventricular or ventricular arrhythmias. Disease onset is usually in early to mid-adulthood. Sudden cardiac death may occur and may be the presenting symptom. In some cases, it is associated with skeletal myopathy and elevated serum creatine kinase." }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "CDCD1", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "LMNA familial isolated dilated cardiomyopathy", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "cardiomyopathy dilated with conduction defect type 1", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "cardiomyopathy, dilated, type 1A", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "dilated cardiomyopathy 1A", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "dilated cardiomyopathy type 1A", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "dilated cardiomyopathy with conduction defect 1", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "familial dilated cardiomyopathy with conduction defect due to LMNA mutation", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "familial isolated dilated cardiomyopathy caused by mutation in LMNA", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "cardiomyopathy, congestive", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "cardiomyopathy, dilated, 1A", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "cardiomyopathy, dilated, with conduction defect 1", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "cardiomyopathy, familial idiopathic", "description": "" }, { "id": "MONDO:0007269", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007269", "name": "cardiomyopathy, idiopathic dilated", "description": "" }, { "id": "MIM:115200", "resource": "MIM", "url": "https://www.omim.org/entry/115200", "name": "Cardiomyopathy, dilated, 1A", "description": "Cardiomyopathy, dilated, 1A" } ], "evidence": [ { "id": "12930", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:12930" } ] }, { "disease_id": "DOID:700", "recommended_name": { "id": "DOID:700", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:700", "name": "mitochondrial metabolism disease", "description": "An inherited metabolic disorder that involves mitochondrial metabolism dysfunction." }, "synonyms": [], "evidence": [ { "id": "700", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:700" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "Q925S8", "url": "https://www.uniprot.org/uniprot/Q925S8" } ], "common_name": "Rat" } ], "gene": [ { "name": "Yme1l1", "url": "https://www.uniprot.org/uniprot/Q925S8", "locus": { "chromosome": "17", "start_pos": 85326335, "end_pos": 85287554, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSRNOG00000055012", "url": "https://www.ensembl.org/id/ENSRNOG00000055012" } ] } } ], "crossref": [ { "id": "ENSRNOG00000017100", "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000017100", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd19501", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd19501", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "114217", "url": "https://www.ncbi.nlm.nih.gov/gene/114217", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "G3V886", "url": "https://www.ebi.ac.uk/intact/interactors/id:G3V886*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "Q925S8", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q925S8*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000642", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000642", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003593", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003593", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003959", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003959", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003960", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003960", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR005936", "url": "https://www.ebi.ac.uk/interpro/entry/IPR005936", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR037219", "url": "https://www.ebi.ac.uk/interpro/entry/IPR037219", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041569", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041569", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "RCWPVYV", "url": "https://omabrowser.org/oma/group/RCWPVYV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR23076", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23076", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR23076:SF97", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23076:SF97", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00004", "url": "http://pfam.xfam.org/family/PF00004", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF01434", "url": "http://pfam.xfam.org/family/PF01434", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF17862", "url": "http://pfam.xfam.org/family/PF17862", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q925S8", "url": "http://purl.obolibrary.org/obo/PR_Q925S8", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-RNO-8949664", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8949664", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "620764", "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=620764", "database": "RGD", "categories": [ "Organism-specific" ] }, { "id": "A0A0G2K0B5", "url": "https://www.uniprot.org/uniprot/A0A0G2K0B5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0G2K0B5-1", "url": "https://www.uniprot.org/uniprot/A0A0G2K0B5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZQI4", "url": "https://www.uniprot.org/uniprot/A0A8I5ZQI4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5ZQI4-1", "url": "https://www.uniprot.org/uniprot/A0A8I5ZQI4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3V886", "url": "https://www.uniprot.org/uniprot/G3V886", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "G3V886-1", "url": "https://www.uniprot.org/uniprot/G3V886-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q925S8", "url": "https://www.uniprot.org/uniprot/Q925S8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q925S8-1", "url": "https://www.uniprot.org/uniprot/Q925S8-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFSLSSTVQPQVTVPLSHLINAFHSPKNISVSVNTSASPKQHRDTVAEHEAPSSEPVLNLRDLGLSELKIGQIDKLVENLLPGFYKDKRVSSCWHTSHISAQSFFENKYGHLDMFSTLRSSSLYRQHPKTLQSICSDLQNFPVFIQSRGFKTLKSRTRRLQSTSERLAEAQNIAPSFVKGFLLRDRGTDLESLDKLMKTKNIPEAHQDAFKTGFAEGFLKAQALTQKTNDSLRRTRLILFVLLLFGIYGLLKNPFLSVRFRTTTGLDSAVDPVQMKNVTFEHVKGVEEAKQELQEVVEFLKNPQKFTVLGGKLPKGILLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIEFPMHPYSRQTIIQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKGRTEILKWYLNKIKFDKSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMVTMKELEFSKDKILMGPERRSVEIDNKNKTITAYHESGHAIIAYYTKDAMPINKATIMPRGPTLGHVSLLPENDRWNEIRAQLLAQMDVSMGGRVAEELIFGTDHITTGASSDFDNATKIAKRMVTKFGMSEKLGVMTYSDTGKLSPETQSAIEQEIRILLRESYERAKHILKTHAKEHKNLAEALLTYETLDAKEIQIVLEGKKLEVR", "length": 715, "header": "sp|Q925S8-1|YMEL1_RAT Isoform 1 of ATP-dependent zinc metalloprotease YME1L1 OS=Rattus norvegicus OX=10116 GN=Yme1l1 PE=2 SV=1 CANONICAL=Q925S8-1" }, "isoforms": [ { "isoform_ac": "A0A0G2K0B5-1", "url": "", "sequence": { "sequence": "MFSLSSTVQPQFLSVISSMPSIHQKIYPFPSIHLLLQNSIEIQLLSMKLPPVLNLRDLGLSELKIGQIDKLVENLLPGFYKDKRVSSCWHTSHISAQSFFENKYGHLDMFSTLRSSSLYRQHPKTLQSICSDLQNFPVFIQSRGFKTLKSRTRRLQSTSERLAEAQNIAPSFVKGFLLRDRGTDLESLDKLMKTKNIPEAHQDAFKTGFAEGFLKAQALTQKTNDSLRRTRLILFVLLLFGIYGLLKNPFLSVRFRTTTGLDSAVDPVQMKNVTFEHVKGVEEAKQELQEVVEFLKNPQKFTVLGGKLPKVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIESPMHPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKGRTEILKWYLNKIKFDKSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMVTMKELEFSKDKILMGPERRSVEIDNKNKTITAYHESGHAIIAYYTKDAMPINKATIMPRGPTLGHVSLLPENDRWNETRAQLLAQMDVSMGGRVAEELIFGTDHITTGASSDFDNATKIAKRMVTKFGMSEKLGVMTYSDTGKLSPETQSAIEQEIRILLRESYERAKHILKTHAKEHKNLAEALLTYETLDAKEIQIVLEGKKLEVR", "length": 706, "header": "tr|A0A0G2K0B5-1|YMEL1_RAT Computationally mapped isoform of ATP-dependent zinc metalloprotease YME1L1 OS=Rattus norvegicus OX=10116 GN=Yme1l1 PE=2 SV=1 CANONICAL=Q925S8-1" }, "locus": { "chromosome": "17", "start_pos": 85325398, "end_pos": 85288182, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000081249.2", "url": "https://www.ensembl.org/id/ENSRNOT00000081249.2" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000071378.2", "url": "https://www.ensembl.org/id/ENSRNOP00000071378.2" } ] } }, { "isoform_ac": "A0A8I5ZQI4-1", "url": "", "sequence": { "sequence": "MFSLSSTVQPQVTVPLSHLINAFHSPKNISVSVNTSASPKQHRDTVAEHEAPSSEPVLNLRDLGLSELKIGQIDKLVENLLPGFYKDKRVSSCWHTSHISAQSFFENKYGHLDMFSTLRSSSLYRQHPKTLQSICSDLQNFPVFIQSRGFKTLKSRTRRLQSTSERLAEAQNIAPSFVKGFLLRDRGTDLESLDKLMKTKNIPEAHQDAFKTGFAEGFLKAQALTQKTNDSLRRTRLILFVLLLFGIYGLLKNPFLSVRFRTTTGLDSAVDPVQMKNVTFEHVKGVEEAKQELQEVVEFLKNPQKFTVLGGKLPKGILLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIESPMHPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKGRTEILKWYLNKIKFDKSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMVTMKELEFSKDKILMGPERRSVEIDNKNKTITAYHESGHAIIAYYTKDAMPINKATIMPRGPTLGHVSLLPENDRWNETRAQLLAQMDVSMGGRVAEELIFGTDHITTGASSDFDNATKIAKRMVTKFGMSEKLGVMTYSDTGKLSPETQSAIEQEIRILLRVILF", "length": 672, "header": "tr|A0A8I5ZQI4-1|A0A8I5ZQI4_RAT Computationally mapped isoform of ATP-dependent zinc metalloprotease YME1L1 OS=Rattus norvegicus OX=10116 GN=Yme1l1 PE=1 SV=1 CANONICAL=Q925S8-1" }, "locus": { "chromosome": "17", "start_pos": 85324030, "end_pos": 85288182, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000108331.1", "url": "https://www.ensembl.org/id/ENSRNOT00000108331.1" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000080549.1", "url": "https://www.ensembl.org/id/ENSRNOP00000080549.1" } ] } }, { "isoform_ac": "G3V886-1", "url": "", "sequence": { "sequence": "MWRTWVTVPLSHLINAFHSPKNISVSVNTSASPKQHRDTVAEHEAPSSEPVLNLRDLGLSELKIGQIDKLVENLLPGFYKDKRVSSCWHTSHISAQSFFENKYGHLDMFSTLRSSSLYRQHPKTLQSICSDLQNFPVFIQSRGFKTLKSRTRRLQSTSERLAEAQNIAPSFVKGFLLRDRGTDLESLDKLMKTKNIPEAHQDAFKTGFAEGFLKAQALTQKTNDSLRRTRLILFVLLLFGIYGLLKNPFLSVRFRTTTGLDSAVDPVQMKNVTFEHVKGVEEAKQELQEVVEFLKNPQKFTVLGGKLPKGILLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIESPMHPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKGRTEILKWYLNKIKFDKSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMVTMKELEFSKDKILMGPERRSVEIDNKNKTITAYHESGHAIIAYYTKDAMPINKATIMPRGPTLGHVSLLPENDRWNETRAQLLAQMDVSMGGRVAEELIFGTDHITTGASSDFDNATKIAKRMVTKFGMSEKLGVMTYSDTGKLSPETQSAIEQEIRILLRESYERAKHILKTHAKEHKNLAEALLTYETLDAKEIQIVLEGKKLEVR", "length": 709, "header": "tr|G3V886-1|YMEL1_RAT Computationally mapped isoform of ATP-dependent zinc metalloprotease YME1L1 OS=Rattus norvegicus OX=10116 GN=Yme1l1 PE=2 SV=2 CANONICAL=Q925S8-1" }, "locus": { "chromosome": "17", "start_pos": 85325398, "end_pos": 85287755, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSRNOT00000023395.7", "url": "https://www.ensembl.org/id/ENSRNOT00000023395.7" }, { "database": "Ensembl Peptide", "id": "ENSRNOP00000023395.5", "url": "https://www.ensembl.org/id/ENSRNOP00000023395.5" } ] } }, { "isoform_ac": "Q925S8-1", "url": "", "sequence": { "sequence": "MFSLSSTVQPQVTVPLSHLINAFHSPKNISVSVNTSASPKQHRDTVAEHEAPSSEPVLNLRDLGLSELKIGQIDKLVENLLPGFYKDKRVSSCWHTSHISAQSFFENKYGHLDMFSTLRSSSLYRQHPKTLQSICSDLQNFPVFIQSRGFKTLKSRTRRLQSTSERLAEAQNIAPSFVKGFLLRDRGTDLESLDKLMKTKNIPEAHQDAFKTGFAEGFLKAQALTQKTNDSLRRTRLILFVLLLFGIYGLLKNPFLSVRFRTTTGLDSAVDPVQMKNVTFEHVKGVEEAKQELQEVVEFLKNPQKFTVLGGKLPKGILLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIEFPMHPYSRQTIIQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKGRTEILKWYLNKIKFDKSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMVTMKELEFSKDKILMGPERRSVEIDNKNKTITAYHESGHAIIAYYTKDAMPINKATIMPRGPTLGHVSLLPENDRWNEIRAQLLAQMDVSMGGRVAEELIFGTDHITTGASSDFDNATKIAKRMVTKFGMSEKLGVMTYSDTGKLSPETQSAIEQEIRILLRESYERAKHILKTHAKEHKNLAEALLTYETLDAKEIQIVLEGKKLEVR", "length": 715, "header": "sp|Q925S8-1|YMEL1_RAT Isoform 1 of ATP-dependent zinc metalloprotease YME1L1 OS=Rattus norvegicus OX=10116 GN=Yme1l1 PE=2 SV=1 CANONICAL=Q925S8-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [], "pathway": [ { "id": "R-RNO-8949664", "name": "Processing of SMDT1", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8949664", "resource": "Reactome", "description": "Processing of SMDT1" } ], "orthologs": [ { "uniprot_canonical_ac": "O88967-1", "protein_name": "ATP-dependent zinc metalloprotease YME1L1", "gene_name": "Yme1l1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MFSLSSTVQPQVTIPLSHLINAFHSPKNISVSVNTPVSQKQHRDTVPEHEAPSSEPVLNLRDLGLSELKIGQIDKMVENLLPGFYKDKRVSSCWHTSHISAQSFFENKYGHLDMFSTLRSSSLYRQHPKTLRSICSDLQYFPVFIQSRGFKTLKSRTRRLQSTSERLVEAQNIAPSFVKGFLLRDRGTDLESLDKLMKTKNIPEAHQDAFKTGFAEGFLKAQALTQKTNDSLRRTRLILFVLLLFGIYGLLKNPFLSVRFRTTTGLDSAVDPVQMKNVTFEHVKGVEEAKQELQEVVEFLKNPQKFTVLGGKLPKGILLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIESPMHPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKGRTEILKWYLNKIKFDKSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMVTMKELEFSKDKILMGPERRSVEIDNKNKTITAYHESGHAIIAYYTKDAMPINKATIMPRGPTLGHVSLLPENDRWNETRAQLLAQMDVSMGGRVAEELIFGTDHITTGASSDFDNATKIAKRMVTKFGMSEKLGVMTYSDTGKLSPETQSAIEQEIRILLRESYERAKHILKTHAKEHKNLAEALLTYETLDAKEIQIVLEGKKLEVR", "length": 715 }, "evidence": [ { "id": "45235463", "url": "http://www.informatics.jax.org/homology/45235463", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "metalloendopeptidase activity", "id": "GO:0004222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004222", "evidence": [ { "database": "UniProtKB", "id": "Q925S8", "url": "https://www.uniprot.org/uniprot/Q925S8" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "Q925S8", "url": "https://www.uniprot.org/uniprot/Q925S8" } ], "pmid": "" }, { "name": "ATP hydrolysis activity", "id": "GO:0016887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", "evidence": [ { "database": "UniProtKB", "id": "Q925S8", "url": "https://www.uniprot.org/uniprot/Q925S8" } ], "pmid": "" }, { "name": "ATP-dependent peptidase activity", "id": "GO:0004176", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004176", "evidence": [ { "database": "UniProtKB", "id": "Q925S8", "url": "https://www.uniprot.org/uniprot/Q925S8" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "Q925S8", "url": "https://www.uniprot.org/uniprot/Q925S8" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "Q925S8", "url": "https://www.uniprot.org/uniprot/Q925S8" } ], "pmid": "" }, { "name": "cell population proliferation", "id": "GO:0008283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008283", "evidence": [ { "database": "UniProtKB", "id": "Q925S8", "url": "https://www.uniprot.org/uniprot/Q925S8" } ], "pmid": "" }, { "name": "negative regulation of apoptotic process", "id": "GO:0043066", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", "evidence": [ { "database": "UniProtKB", "id": "Q925S8", "url": "https://www.uniprot.org/uniprot/Q925S8" } ], "pmid": "" }, { "name": "mitochondrion organization", "id": "GO:0007005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007005", "evidence": [ { "database": "UniProtKB", "id": "Q925S8", "url": "https://www.uniprot.org/uniprot/Q925S8" } ], "pmid": "" }, { "name": "mitochondrial protein processing", "id": "GO:0034982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034982", "evidence": [ { "database": "UniProtKB", "id": "Q925S8", "url": "https://www.uniprot.org/uniprot/Q925S8" } ], "pmid": "" }, { "name": "mitochondrial protein catabolic process", "id": "GO:0035694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035694", "evidence": [ { "database": "UniProtKB", "id": "Q925S8", "url": "https://www.uniprot.org/uniprot/Q925S8" } ], "pmid": "" }, { "name": "protein quality control for misfolded or incompletely synthesized proteins", "id": "GO:0006515", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006515", "evidence": [ { "database": "UniProtKB", "id": "Q925S8", "url": "https://www.uniprot.org/uniprot/Q925S8" } ], "pmid": "" }, { "name": "protein hexamerization", "id": "GO:0034214", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034214", "evidence": [ { "database": "UniProtKB", "id": "Q925S8", "url": "https://www.uniprot.org/uniprot/Q925S8" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q925S8", "url": "https://www.uniprot.org/uniprot/Q925S8" } ], "pmid": "" }, { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "Q925S8", "url": "https://www.uniprot.org/uniprot/Q925S8" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "Q925S8", "url": "https://www.uniprot.org/uniprot/Q925S8" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 229, "end_pos": 231, "annotation": "n_glycosylation_sequon" }, { "start_pos": 277, "end_pos": 279, "annotation": "n_glycosylation_sequon" }, { "start_pos": 28, "end_pos": 30, "annotation": "n_glycosylation_sequon" }, { "start_pos": 34, "end_pos": 36, "annotation": "n_glycosylation_sequon" }, { "start_pos": 534, "end_pos": 536, "annotation": "n_glycosylation_sequon" }, { "start_pos": 622, "end_pos": 624, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Proteolytically processed by mitochondrial processing peptidase (MPP) to generate the mature form.", "evidence": [ { "database": "UniProtKB", "id": "Q925S8", "url": "https://www.uniprot.org/uniprot/Q925S8" }, { "database": "PubMed", "id": "Q96TA2", "url": "https://glygen.org/publication/PubMed/Q96TA2" } ] } ], "interactions": [], "reactions": [ { "id": "R-RNO-8949668", "name": "YME1L1 proteolyzes unassembled proSMDT1", "equation": "", "summary": "This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.

More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp", "cellular_location": "mitochondrial inner membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q3B8P0-1", "Q925S8-1" ], "evidence": [ { "id": "R-RNO-8949668", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8949668" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "Q3B8P0", "gene_name": "Parl", "activity": [ { "ec_number": "3.4.21.105", "activity": "Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.", "evidence": [ { "id": "Q3B8P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3B8P0" } ] }, { "ec_number": "3.4.21.105", "activity": "", "evidence": [ { "id": "Q3B8P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3B8P0" } ] } ] }, { "uniprot_ac": "Q925S8", "gene_name": "Yme1l1", "activity": [ { "ec_number": "3.4.24.-", "activity": "", "evidence": [ { "id": "Q925S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q925S8" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] } ] }