{ "uniprot_canonical_ac": "Q924X6-1", "uniprot_ac": "Q924X6", "uniprot_id": "LRP8_MOUSE", "mass": { "chemical_mass": 109818.0, "monoisotopic_mass": 109818.0 }, "refseq": { "ac": "XP_011238762", "name": "low-density lipoprotein receptor-related protein 8 isoform X7", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_011238762" }, "gene_names": [ { "name": "Lrp8", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/Q924X6", "id": "Q924X6" }, { "name": "4932703M08Rik; ApoER2; Lr8b", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074395", "id": "NP_001074395" }, { "name": "Apoer2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/Q924X6", "id": "Q924X6" }, { "name": "Lrp8", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074395", "id": "NP_001074395" } ], "protein_names": [ { "name": "Low-density lipoprotein receptor-related protein 8", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "Q924X6" }, { "name": "Apolipoprotein E receptor 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q924X6" }, { "name": "LRP-8", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "Q924X6" }, { "name": "low density lipoprotein receptor relative, 8 ligand binding repeats, brain; low-density lipoprotein receptor-related protein 8; apolipoprotein E receptor 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074395", "id": "NP_001074395" }, { "name": "low-density lipoprotein receptor-related protein 8 isoform X14", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_011238764", "id": "XP_011238764" }, { "name": "low-density lipoprotein receptor-related protein 8 isoform X21", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_011238768", "id": "XP_011238768" }, { "name": "low-density lipoprotein receptor-related protein 8 isoform X7", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_011238762", "id": "XP_011238762" }, { "name": "low-density lipoprotein receptor-related protein 8 isoform b precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074395", "id": "NP_001074395" } ], "function": [ { "annotation": "Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation (PubMed:12695510). May also function as an endocytic receptor. Not required for endocytic uptake of SEPP1 in the kidney which is mediated by LRP2 (PubMed:18174160). Together with its ligand, apolipoprotein E (apoE), may indirectly play a role in the suppression of the innate immune response by controlling the survival of myeloid-derived suppressor cells (PubMed:29336888).", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6#function" }, { "database": "PubMed", "id": "12695510", "url": "https://glygen.org/publication/PubMed/12695510" }, { "database": "PubMed", "id": "18174160", "url": "https://glygen.org/publication/PubMed/18174160" }, { "database": "PubMed", "id": "29336888", "url": "https://glygen.org/publication/PubMed/29336888" } ] }, { "annotation": "Different sensitivity to diet-induced hyperinsulinemia and hyperglycemia between mice with global or bone marrow-specific apoE receptor-2 deficiency.", "evidence": [ { "database": "RefSeq", "id": "NP_001074395", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074395" }, { "database": "PubMed", "id": "37212552", "url": "https://glygen.org/publication/PubMed/37212552" } ] }, { "annotation": "Regulation of the hippocampal translatome by Apoer2-ICD release. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001074395", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074395" }, { "database": "PubMed", "id": "37726747", "url": "https://glygen.org/publication/PubMed/37726747" } ] }, { "annotation": "Single molecule, long-read Apoer2 sequencing identifies conserved and species-specific splicing patterns.", "evidence": [ { "database": "RefSeq", "id": "NP_001074395", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074395" }, { "database": "PubMed", "id": "35192893", "url": "https://glygen.org/publication/PubMed/35192893" } ] }, { "annotation": "VLDLR and ApoER2 are receptors for multiple alphaviruses.", "evidence": [ { "database": "RefSeq", "id": "NP_001074395", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074395" }, { "database": "PubMed", "id": "34929721", "url": "https://glygen.org/publication/PubMed/34929721" } ] } ], "disease": [ { "disease_id": "DOID:10652", "recommended_name": { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimer's disease", "description": "A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid." }, "synonyms": [ { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimer disease", "description": "" }, { "id": "DOID:10652", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10652", "name": "Alzheimers dementia", "description": "" } ], "evidence": [ { "id": "10652", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:10652" } ] }, { "disease_id": "DOID:1307", "recommended_name": { "id": "DOID:1307", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1307", "name": "dementia", "description": "A cognitive disorder resulting from a loss of brain function affecting memory, thinking, language, judgement and behavior." }, "synonyms": [], "evidence": [ { "id": "1307", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:1307" } ] }, { "disease_id": "DOID:3393", "recommended_name": { "id": "DOID:3393", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3393", "name": "coronary artery disease", "description": "An artery disease that is characterized by plaque building up along the inner walls of the arteries of the heart resulting in a narrowing of the arteries and a reduced blood supply to the cardiac muscles." }, "synonyms": [ { "id": "DOID:3393", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3393", "name": "CHD", "description": "" }, { "id": "DOID:3393", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3393", "name": "Coronary disease", "description": "" }, { "id": "DOID:3393", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3393", "name": "coronary arteriosclerosis", "description": "" }, { "id": "DOID:3393", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3393", "name": "coronary heart disease", "description": "" }, { "id": "MONDO:0012010", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012010", "name": "coronary heart disease, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012010", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012010", "name": "coronary heart disease, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012010", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012010", "name": "coronary heart disease, susceptibility to, type 4", "description": "" }, { "id": "MONDO:0012010", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012010", "name": "Chds4", "description": "" }, { "id": "MONDO:0012009", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012009", "name": "coronary heart disease, susceptibility to, 2", "description": "" }, { "id": "MONDO:0012009", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012009", "name": "coronary heart disease, susceptibility to, 2", "description": "" }, { "id": "MONDO:0012009", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012009", "name": "coronary heart disease, susceptibility to, type 2", "description": "" }, { "id": "MONDO:0012009", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012009", "name": "Chds2", "description": "" }, { "id": "MONDO:0013671", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013671", "name": "hydatidiform mole, recurrent, 2", "description": "Any complete hydatidiform mole in which the cause of the disease is a mutation in the KHDC3L gene." }, { "id": "MONDO:0013671", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013671", "name": "KHDC3L complete hydatidiform mole", "description": "" }, { "id": "MONDO:0013671", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013671", "name": "complete hydatidiform mole caused by mutation in KHDC3L", "description": "" }, { "id": "MONDO:0013671", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013671", "name": "hydatidiform Mole, recurrent, type 2", "description": "" }, { "id": "MONDO:0013671", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013671", "name": "hydatidiform mole, recurrent, 2", "description": "" }, { "id": "MONDO:0013671", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013671", "name": "HYDM2", "description": "" }, { "id": "MONDO:0013671", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013671", "name": "hydatidiform MOLE, recurrent, 2", "description": "" }, { "id": "MONDO:0013671", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013671", "name": "hydatidiform Mole, complete", "description": "" }, { "id": "MONDO:0011817", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011817", "name": "coronary heart disease, susceptibility to, 1", "description": "Any coronary artery disease in which the cause of the disease is a mutation in the CX3CR1 gene." }, { "id": "MONDO:0011817", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011817", "name": "CX3CR1 coronary artery disease", "description": "" }, { "id": "MONDO:0011817", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011817", "name": "coronary artery disease caused by mutation in CX3CR1", "description": "" }, { "id": "MONDO:0011817", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011817", "name": "coronary artery disease, resistance to", "description": "" }, { "id": "MONDO:0011817", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011817", "name": "coronary heart disease, susceptibility to", "description": "" }, { "id": "MONDO:0011817", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011817", "name": "coronary heart disease, susceptibility to, 1", "description": "" }, { "id": "MONDO:0011817", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011817", "name": "coronary heart disease, susceptibility to, type 1", "description": "" }, { "id": "MONDO:0011817", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011817", "name": "Chds1", "description": "" }, { "id": "MONDO:0012011", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012011", "name": "coronary artery disease, autosomal dominant, 1", "description": "Any coronary artery disease in which the cause of the disease is a mutation in the MEF2A gene." }, { "id": "MONDO:0012011", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012011", "name": "MEF2A coronary artery disease", "description": "" }, { "id": "MONDO:0012011", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012011", "name": "coronary artery disease caused by mutation in MEF2A", "description": "" }, { "id": "MONDO:0012011", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012011", "name": "coronary artery disease, autosomal dominant, 1", "description": "" }, { "id": "MONDO:0012011", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012011", "name": "coronary artery disease, autosomal dominant, type 1", "description": "" }, { "id": "MONDO:0012011", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012011", "name": "ADCAD1", "description": "" }, { "id": "MONDO:0012011", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012011", "name": "coronary artery disease with myocardial infarction", "description": "" }, { "id": "MONDO:0012586", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012586", "name": "coronary artery disease, autosomal dominant 2", "description": "Any coronary artery disease in which the cause of the disease is a mutation in the LRP6 gene." }, { "id": "MONDO:0012586", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012586", "name": "LRP6 coronary artery disease", "description": "" }, { "id": "MONDO:0012586", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012586", "name": "coronary artery disease caused by mutation in LRP6", "description": "" }, { "id": "MONDO:0012586", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012586", "name": "coronary artery disease, autosomal dominant 2", "description": "" }, { "id": "MONDO:0012586", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012586", "name": "coronary artery disease, autosomal dominant type 2", "description": "" }, { "id": "MONDO:0012586", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012586", "name": "coronary artery disease, autosomal dominant, 2", "description": "" }, { "id": "MONDO:0012586", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012586", "name": "ADCAD2", "description": "" }, { "id": "MONDO:0012788", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012788", "name": "coronary heart disease, susceptibility to, 9", "description": "" }, { "id": "MONDO:0012788", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012788", "name": "CHDS9", "description": "" }, { "id": "MONDO:0012788", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012788", "name": "coronary heart disease, susceptibility to, 9", "description": "" }, { "id": "MONDO:0010331", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010331", "name": "coronary heart disease, susceptibility to, 3", "description": "" }, { "id": "MONDO:0010331", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010331", "name": "coronary heart disease, susceptibility to, 3", "description": "" }, { "id": "MONDO:0010331", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010331", "name": "coronary heart disease, susceptibility to, type 3", "description": "" }, { "id": "MONDO:0010331", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010331", "name": "Chds3", "description": "" }, { "id": "MONDO:0012628", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012628", "name": "coronary heart disease, susceptibility to, 8", "description": "" }, { "id": "MONDO:0012628", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012628", "name": "CHDS8", "description": "" }, { "id": "MONDO:0012628", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012628", "name": "coronary heart disease, susceptibility to, 8", "description": "" }, { "id": "MIM:614293", "resource": "MIM", "url": "https://www.omim.org/entry/614293", "name": "Hydatidiform mole, recurrent, 2", "description": "Hydatidiform mole, recurrent, 2" }, { "id": "MIM:608320", "resource": "MIM", "url": "https://www.omim.org/entry/608320", "name": "Coronary artery disease, autosomal dominant, 1", "description": "Coronary artery disease, autosomal dominant, 1" }, { "id": "MIM:610947", "resource": "MIM", "url": "https://www.omim.org/entry/610947", "name": "Coronary artery disease, autosomal dominant, 2", "description": "Coronary artery disease, autosomal dominant, 2" } ], "evidence": [ { "id": "3393", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:3393" } ] }, { "disease_id": "DOID:5419", "recommended_name": { "id": "DOID:5419", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5419", "name": "schizophrenia", "description": "A psychotic disorder that is characterized by a disintegration of thought processes and of emotional responsiveness." }, "synonyms": [ { "id": "DOID:5419", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5419", "name": "schizophrenia-1", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizophrenia", "description": "A major psychotic disorder characterized by abnormalities in the perception or expression of reality. It affects the cognitive and psychomotor functions. Common clinical signs and symptoms include delusions, hallucinations, disorganized thinking, and retreat from reality." }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizophrenia 12", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizophrenia", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizophrenia (disease)", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizophrenia-1", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "SCZD", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizoaffective disorder", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizophrenia with or without an affective disorder", "description": "" }, { "id": "MONDO:0005090", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005090", "name": "schizophrenia, susceptibility to", "description": "" }, { "id": "MIM:181500", "resource": "MIM", "url": "https://www.omim.org/entry/181500", "name": "Schizophrenia", "description": "Schizophrenia" } ], "evidence": [ { "id": "5419", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:5419" } ] }, { "disease_id": "DOID:5844", "recommended_name": { "id": "DOID:5844", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5844", "name": "myocardial infarction", "description": "A coronary artery disease characterized by myocardial cell death (myocardial necrosis) due to prolonged ischaemia." }, "synonyms": [ { "id": "DOID:5844", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5844", "name": "Myocardial infarct", "description": "" }, { "id": "DOID:5844", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5844", "name": "heart attack", "description": "" }, { "id": "MONDO:0012058", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012058", "name": "myocardial infarction, susceptibility to, 2", "description": "" }, { "id": "MONDO:0012058", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012058", "name": "myocardial infarction, susceptibility to, 2", "description": "" }, { "id": "MONDO:0012058", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012058", "name": "myocardial infarction, susceptibility to, type 2", "description": "" }, { "id": "MONDO:0012058", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012058", "name": "Mci2", "description": "" } ], "evidence": [ { "id": "5844", "database": "Alliance of Genome Resources", "url": "https://www.alliancegenome.org/disease/DOID:5844" } ] } ], "snv": [ { "evidence": [ { "id": "rs213514492", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs213514492" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 107, "end_pos": 107, "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DGS->NGS).", "chr_id": "4", "chr_pos": "107712803", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D107", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [ { "start_pos": 102, "end_pos": 102, "sequence_org": "E", "sequence_mut": "Q", "comment": "Same affinity for RAP. Same affinity for Reelin.", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" }, { "database": "PubMed", "id": "12899622", "url": "https://glygen.org/publication/PubMed/12899622" } ] }, { "start_pos": 145, "end_pos": 145, "sequence_org": "E", "sequence_mut": "Q", "comment": "Same affinity for RAP. Lower affinity for Reelin.", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" }, { "database": "PubMed", "id": "12899622", "url": "https://glygen.org/publication/PubMed/12899622" } ] }, { "start_pos": 61, "end_pos": 61, "sequence_org": "D", "sequence_mut": "N", "comment": "Lower affinity for RAP. Abolishes binding to Reelin.", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" }, { "database": "PubMed", "id": "12899622", "url": "https://glygen.org/publication/PubMed/12899622" } ] } ], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Mus musculus", "taxid": 10090, "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "common_name": "Mouse" } ], "gene": [ { "name": "Lrp8", "url": "https://www.uniprot.org/uniprot/Q924X6", "locus": { "chromosome": "4", "start_pos": 107734037, "end_pos": 107659066, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSMUSG00000028613", "url": "https://www.ensembl.org/id/ENSMUSG00000028613" } ] } } ], "crossref": [ { "id": "ENSMUSG00000028613", "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000028613", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00054", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00054", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00112", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00112", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "16975", "url": "https://www.ncbi.nlm.nih.gov/gene/16975", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "2487", "url": "https://glyconnect.expasy.org/browser/proteins/2487", "database": "GlyConnect", "categories": [ "Glycan", "Glycoproteomics" ] }, { "id": "Q924X6", "url": "https://www.ebi.ac.uk/intact/interactors/id:Q924X6*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000033", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000033", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000152", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000152", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001881", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001881", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002172", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002172", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011042", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011042", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018097", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018097", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023415", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023415", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036055", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036055", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "mmu:16975", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:16975", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "1340044", "url": "http://www.informatics.jax.org/marker/MGI:1340044", "database": "MGI", "categories": [ "Organism-specific" ] }, { "id": "XLNECLH", "url": "https://omabrowser.org/oma/group/XLNECLH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "3918101at2759", "url": "http://www.orthodb.org/?query=3918101at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22722", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22722", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22722:SF11", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22722:SF11", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46513", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46513", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46513:SF13", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46513:SF13", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00057", "url": "http://pfam.xfam.org/family/PF00057", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00058", "url": "http://pfam.xfam.org/family/PF00058", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF07645", "url": "http://pfam.xfam.org/family/PF07645", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF14670", "url": "http://pfam.xfam.org/family/PF14670", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_Q924X6", "url": "http://purl.obolibrary.org/obo/PR_Q924X6", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-MMU-432142", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-432142", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-MMU-975634", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-975634", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_011238759", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_011238759", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A571BDC7", "url": "https://www.uniprot.org/uniprot/A0A571BDC7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A571BDC7-1", "url": "https://www.uniprot.org/uniprot/A0A571BDC7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A571BDQ2", "url": "https://www.uniprot.org/uniprot/A0A571BDQ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A571BDQ2-1", "url": "https://www.uniprot.org/uniprot/A0A571BDQ2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A571BE60", "url": "https://www.uniprot.org/uniprot/A0A571BE60", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A571BE60-1", "url": "https://www.uniprot.org/uniprot/A0A571BE60-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A571BE80", "url": "https://www.uniprot.org/uniprot/A0A571BE80", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A571BE80-1", "url": "https://www.uniprot.org/uniprot/A0A571BE80-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A571BEC8", "url": "https://www.uniprot.org/uniprot/A0A571BEC8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A571BEC8-1", "url": "https://www.uniprot.org/uniprot/A0A571BEC8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A571BEF2", "url": "https://www.uniprot.org/uniprot/A0A571BEF2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A571BEF2-1", "url": "https://www.uniprot.org/uniprot/A0A571BEF2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A571BGD2", "url": "https://www.uniprot.org/uniprot/A0A571BGD2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A571BGD2-1", "url": "https://www.uniprot.org/uniprot/A0A571BGD2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B1AXJ3", "url": "https://www.uniprot.org/uniprot/B1AXJ3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B1AXJ3-1", "url": "https://www.uniprot.org/uniprot/B1AXJ3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B1AXJ4", "url": "https://www.uniprot.org/uniprot/B1AXJ4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B1AXJ4-1", "url": "https://www.uniprot.org/uniprot/B1AXJ4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B1AXJ5", "url": "https://www.uniprot.org/uniprot/B1AXJ5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B1AXJ5-1", "url": "https://www.uniprot.org/uniprot/B1AXJ5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B1AXJ6", "url": "https://www.uniprot.org/uniprot/B1AXJ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B1AXJ6-1", "url": "https://www.uniprot.org/uniprot/B1AXJ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6YZZ8", "url": "https://www.uniprot.org/uniprot/F6YZZ8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6YZZ8-1", "url": "https://www.uniprot.org/uniprot/F6YZZ8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q924X6-1", "url": "https://www.uniprot.org/uniprot/Q924X6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q924X6-2", "url": "https://www.uniprot.org/uniprot/Q924X6-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGRPELGALRPLALLLLLLLQLQHLSAADPLPGGQGPVKECEEDQFRCRNERCIPLVWRCDEDNDCSDNSDEDDCPKRTCADSDFTCDNGHCIPERWKCDGEEECPDGSDESKATCSSEECPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCPTLCAPHEFQCSNRSCLASVFVCDGDDDCGDGSDERGCSDPACPPREFRCGGGGTCIPERWVCDRQFDCEDRSDEAAELCGRAGQGTTATPAACAPTAQFTCRSGECIHLGWRCDGDRDCKDKSDEADCSPGPCRENEFQCGDGTCVLAIKRCNQERDCPDGSDEAGCLQESTCEGPRRFQCKSGECVDGGKVCDDQRDCRDWSDEPQKVCGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECQDPDACSQICVNYKGYFKCECHPGYEMDTLTKNCKAVAGKSPSLIFTNRHEVRRIDLVKRDYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAHMDKASIPDEQVVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATTDGRRRCTLFSRELSEPRAIAVDPLRGFMYWSDWGFQAKIEKAGLNGADRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFNGGNRKMLIFSTDFLSHPFGVAVFEDKVFWTDLENEAIFSANRLNGLEIAILAENLNNPHDIVIFHELKQPKAADACDLSAQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASAMTRTVPATTRAPGTTIHDPTYQNHSTETPSQTAAAPHSVNVPRAPSTSPSTPSPATSNHSQHYGNEGSQMGSTVTAAVIGVIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEEEDELHIGRTAQIGHVYPAAISNYDRPLWAEPCLGETRDLEDPAPALKELFVLPGEPRSQLHQLPKNPLSELPVVKCKRVALSLEDDGLP", "length": 996, "header": "sp|Q924X6-1|LRP8_MOUSE Isoform 1 of Low-density lipoprotein receptor-related protein 8 OS=Mus musculus OX=10090 GN=Lrp8 PE=1 SV=2 CANONICAL=Q924X6-1" }, "isoforms": [ { "isoform_ac": "A0A571BDC7-1", "url": "", "sequence": { "sequence": "XEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRDGNEGSQMGSTVTAAVIGVIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEEEDELHIGRTAQIGHVYPAAISNYDRPLWAEPCLGETRDLEDPAPALKELFVLPGEPRSQLHQLPKNPLSELPVVKCKRVALSLEDDGLP", "length": 189, "header": "tr|A0A571BDC7-1|LRP8_MOUSE Computationally mapped isoform of Low-density lipoprotein receptor-related protein 8 OS=Mus musculus OX=10090 GN=Lrp8 PE=1 SV=1 CANONICAL=Q924X6-1" }, "locus": { "chromosome": "4", "start_pos": 107729507, "end_pos": 107717172, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000238255.2", "url": "https://www.ensembl.org/id/ENSMUST00000238255.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000158681.2", "url": "https://www.ensembl.org/id/ENSMUSP00000158681.2" } ] } }, { "isoform_ac": "A0A571BDQ2-1", "url": "", "sequence": { "sequence": "XVKRDYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAHMDKASIPDEQVVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATTDGRRRCTLFSRELSEPRAIAVDPLRGLAEPAFVLGGLQAAPTIQH", "length": 135, "header": "tr|A0A571BDQ2-1|A0A571BDQ2_MOUSE Computationally mapped isoform of Low density lipoprotein receptor-related protein 8, apolipoprotein e receptor OS=Mus musculus OX=10090 GN=Lrp8 PE=1 SV=1 CANONICAL=Q924X6-1" }, "locus": { "chromosome": "4", "start_pos": 107714437, "end_pos": 107711504, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000238658.2", "url": "https://www.ensembl.org/id/ENSMUST00000238658.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000158812.2", "url": "https://www.ensembl.org/id/ENSMUSP00000158812.2" } ] } }, { "isoform_ac": "A0A571BE60-1", "url": "", "sequence": { "sequence": "MGRPELGALRPLALLLLLLLQLQHLSAADPLPGGQGPVKECEEDQFRCRNERCIPLVWRCDEDNDCSDNSDEDDCPKRTCADSDFTCDNGHCIPERWKCDGEEECPDGSDESKATCSSEECPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCPTSPGPCRENEFQCGDGTCVLAIKRCNQERDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECQDPDACSQICVNYKGYFKCECHPGYEMDTLTKNCKAVAGKSPSLIFTNRHEVRRIDLVKRDYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAHMDKASIPDEQVVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATTDGRRRCTLFSRELSEPRAIAVDPLRGFMYWSDWGFQAKIEKAGLNGADRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFNGGNRKMLIFSTDFLSHPFGVAVFEDKVFWTDLENEAIFSANRLNGLEIAILAENLNNPHDIVIFHELKQPKAADACDLSAQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASAMTRTVPATTRAPGTTIHDPTYQNHSTETPSQTAAAPHSVNVPRAPSTSPSTPSPATSNHSQHYGNEGSQMGSTVTAAVIGVIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEEEDELHIGRTAQIGHVYPAAISNYDRPLWAEPCLGETRDLEDPAPALKELFVLPGEPRSQLHQLPKNPLSELPVVKCKRVALSLEDDGLP", "length": 828, "header": "tr|A0A571BE60-1|A0A571BE60_MOUSE Computationally mapped isoform of Low density lipoprotein receptor-related protein 8, apolipoprotein e receptor OS=Mus musculus OX=10090 GN=Lrp8 PE=1 SV=1 CANONICAL=Q924X6-1" }, "locus": { "chromosome": "4", "start_pos": 107729505, "end_pos": 107659610, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000238584.2", "url": "https://www.ensembl.org/id/ENSMUST00000238584.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000158610.2", "url": "https://www.ensembl.org/id/ENSMUSP00000158610.2" } ] } }, { "isoform_ac": "A0A571BE80-1", "url": "", "sequence": { "sequence": "MGRPELGALRPLALLLLLLLQLQHLSAADPLPGGQGPVKECEEDQFRCRNERCIPLVWRCDEDNDCSDNSDEDDCPKRTCADSDFTCDNGHCIPERWKCDGEEECPDGSDESKATCSSEECPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCPTWLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECQDPDACSQICVNYKGYFKCECHPGYEMDTLTKNCKAVAGKSPSLIFTNRHEVRRIDLVKRDYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAHMDKASIPDEQVVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATTDGRRRCTLFSRELSEPRAIAVDPLRGFMYWSDWGFQAKIEKAGLNGADRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFNGGNRKMLIFSTDFLSHPFGVAVFEDKVFWTDLENEAIFSANRLNGLEIAILAENLNNPHDIVIFHELKQPKAADACDLSAQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASAMTRTVPATTRAPGTTIHDPTYQNHSTETPSQTAAAPHSVNVPRAPSTSPSTPSPATSNHSQHYGNEGSQMGSTVTAAVIGVIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEEEDELHIGRTAQIGHVYPAAISNYDRPLWAEPCLGETRDLEDPAPALKELFVLPGEPRSQLHQLPKNPLSELPVVKCKRVALSLEDDGLP", "length": 787, "header": "tr|A0A571BE80-1|A0A571BE80_MOUSE Computationally mapped isoform of Low density lipoprotein receptor-related protein 8, apolipoprotein e receptor OS=Mus musculus OX=10090 GN=Lrp8 PE=1 SV=1 CANONICAL=Q924X6-1" }, "locus": { "chromosome": "4", "start_pos": 107729505, "end_pos": 107659610, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000238421.2", "url": "https://www.ensembl.org/id/ENSMUST00000238421.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000158608.2", "url": "https://www.ensembl.org/id/ENSMUSP00000158608.2" } ] } }, { "isoform_ac": "A0A571BEC8-1", "url": "", "sequence": { "sequence": "MGRPELGALRPLALLLLLLLQLQHLSAADPLPGGQGPVKECEEDQFRCRNERCIPLVWRCDEDNDCSDNSDEDDCPKRTCADSDFTCDNGHCIPERWKCDGEEECPDGSDESKATCSPGPCRENEFQCGDGTCVLAIKRCNQERDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECQDPDACSQICVNYKGYFKCECHPGYEMDTLTKNCKAVAGKSPSLIFTNRHEVRRIDLVKRDYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAHMDKASIPDEQVVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATTDGRRRCTLFSRELSEPRAIAVDPLRGFMYWSDWGFQAKIEKAGLNGADRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFNGGNRKMLIFSTDFLSHPFGVAVFEDKVFWTDLENEAIFSANRLNGLEIAILAENLNNPHDIVIFHELKQPKAADACDLSAQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASAMTRTVPATTRAPGTTIHDPTYQNHSTETPSQTAAAPHSVNVPRAPSTSPSTPSPATSNHSQHYGNEGSQMGSTVTAAVIGVIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEEEDELHIGRTAQIGHVYPARVALSLEDDGLP", "length": 726, "header": "tr|A0A571BEC8-1|LRP8_MOUSE Computationally mapped isoform of Low-density lipoprotein receptor-related protein 8 OS=Mus musculus OX=10090 GN=Lrp8 PE=1 SV=1 CANONICAL=Q924X6-1" }, "locus": { "chromosome": "4", "start_pos": 107729505, "end_pos": 107659610, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000238651.2", "url": "https://www.ensembl.org/id/ENSMUST00000238651.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000158650.2", "url": "https://www.ensembl.org/id/ENSMUSP00000158650.2" } ] } }, { "isoform_ac": "A0A571BEF2-1", "url": "", "sequence": { "sequence": "STSPSTPSPATSNHSQHYGNEGSQMGSTVTAAVIGVIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEEEDELHIGRTAQIGHVYPAVTASPTPEEPSFRAACRQVQASGIKS", "length": 124, "header": "tr|A0A571BEF2-1|A0A571BEF2_MOUSE Computationally mapped isoform of Low density lipoprotein receptor-related protein 8, apolipoprotein e receptor OS=Mus musculus OX=10090 GN=Lrp8 PE=1 SV=1 CANONICAL=Q924X6-1" }, "locus": { "chromosome": "4", "start_pos": 107729486, "end_pos": 107718503, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000238693.2", "url": "https://www.ensembl.org/id/ENSMUST00000238693.2" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000158682.2", "url": "https://www.ensembl.org/id/ENSMUSP00000158682.2" } ] } }, { "isoform_ac": "A0A571BGD2-1", "url": "", "sequence": { "sequence": "DEADCSPGPCRENEFQCGDGTCVLAIKRCNQERDCPDGTGKSPSLIFTNRHEVRRIDLVKRDYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAHMDKASIPDEQVVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATTDGRRRCTLFS", "length": 157, "header": "tr|A0A571BGD2-1|A0A571BGD2_MOUSE Computationally mapped isoform of Low density lipoprotein receptor-related protein 8, apolipoprotein e receptor OS=Mus musculus OX=10090 GN=Lrp8 PE=1 SV=1 CANONICAL=Q924X6-1" }, "locus": { "chromosome": "4", "start_pos": 107712955, "end_pos": 107703801, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000135022.3", "url": "https://www.ensembl.org/id/ENSMUST00000135022.3" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000158799.2", "url": "https://www.ensembl.org/id/ENSMUSP00000158799.2" } ] } }, { "isoform_ac": "B1AXJ3-1", "url": "", "sequence": { "sequence": "RPLALLLLLLLQLQHLSAADPLPGGQGPVKECEEDQFRCRNERCIPLVWRCDEDNDCSDNSDEDDCPKRTCADSDFTCDNGHCIPERWKCDGEEECPDGSDESKATCSSEECPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCPTSPGPCRENEFQCGDGTCVLAIKRCNQERDCPDGSDEAGCLQVAPSFPGNRRHPRGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECQDPDACSQICVNYKGYFKCECHPGYEMDTLTKNCKAVAGKSPSLIFTNRHEVRRIDLVKRDYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAHMDKASIPDEQVVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATTDGRRRCTLFSRELSEPRAIAVDPLRGFMYWSDWGFQAKIEKAGLNGADRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFNGGNRKMLIFSTDFLSHPFGVAVFEDKVFWTDLENEAIFSANRLNGLEIAILAENLNNPHDIVIFHELKQPKAADACDLSAQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASAMTRTVPATTRAPGTTIHDPTYQNHSTETPSQTAAAPHSVNVPRAPSTSPSTPSPATSNHSQHYGNEGSQMGSTVTAAVIGVIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEEEDELHIGRTAQIGHVYPAAISNYDRPLWAEPCLGETRDLEDPAPALKELFVLPGEPRSQLHQLPKNPLSELPVVKCKRVALSLEDDGLP", "length": 832, "header": "tr|B1AXJ3-1|LRP8_MOUSE Computationally mapped isoform of Low-density lipoprotein receptor-related protein 8 OS=Mus musculus OX=10090 GN=Lrp8 PE=1 SV=2 CANONICAL=Q924X6-1" }, "locus": { "chromosome": "4", "start_pos": 107729505, "end_pos": 107659637, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000106732.10", "url": "https://www.ensembl.org/id/ENSMUST00000106732.10" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000102343.4", "url": "https://www.ensembl.org/id/ENSMUSP00000102343.4" } ] } }, { "isoform_ac": "B1AXJ4-1", "url": "", "sequence": { "sequence": "MGRPELGALRPLALLLLLLLQLQHLSAADPLPGGQGPVKECEEDQFRCRNERCIPLVWRCDEDNDCSDNSDEDDCPKRTCADSDFTCDNGHCIPERWKCDGEEECPDGSDESKATCSSEECPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCPTLCAPHEFQCSNRSCLASVFVCDGDDDCGDGSDERGCSDPACPPREFRCGGGGTCIPERWVCDRQFDCEDRSDEAAELCGRAGQGTTATPAACAPTAQFTCRSGECIHLGWRCDGDRDCKDKSDEADCSPGPCRENEFQCGDGTCVLAIKRCNQERDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECQDPDACSQICVNYKGYFKCECHPGYEMDTLTKNCKAVAGKSPSLIFTNRHEVRRIDLVKRDYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAHMDKASIPDEQVVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATTDGRRRCTLFSRELSEPRAIAVDPLRGFMYWSDWGFQAKIEKAGLNGADRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFNGGNRKMLIFSTDFLSHPFGVAVFEDKVFWTDLENEAIFSANRLNGLEIAILAENLNNPHDIVIFHELKQPKAADACDLSAQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASAMTRTVPATTRAPGTTIHDPTYQNHSTETPSQTAAAPHSVNVPRAPSTSPSTPSPATSNHSQHYGNEGSQMGSTVTAAVIGVIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEEEDELHIGRTAQIGHVYPAAISNYDRPLWAEPCLGETRDLEDPAPALKELFVLPGEPRSQLHQLPKNPLSELPVVKCKRVALSLEDDGLP", "length": 955, "header": "tr|B1AXJ4-1|LRP8_MOUSE Computationally mapped isoform of Low-density lipoprotein receptor-related protein 8 OS=Mus musculus OX=10090 GN=Lrp8 PE=1 SV=1 CANONICAL=Q924X6-1" }, "locus": { "chromosome": "4", "start_pos": 107729505, "end_pos": 107659610, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000030356.10", "url": "https://www.ensembl.org/id/ENSMUST00000030356.10" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000030356.4", "url": "https://www.ensembl.org/id/ENSMUSP00000030356.4" } ] } }, { "isoform_ac": "B1AXJ5-1", "url": "", "sequence": { "sequence": "MGRPELGALRPLALLLLLLLQLQHLSAADPLPGGQGPVKECEEDQFRCRNERCIPLVWRCDEDNDCSDNSDEDDCPKRTCADSDFTCDNGHCIPERWKCDGEEECPDGSDESKATCSSEECPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCPTLCAPHEFQCSNRSCLASVFVCDGDDDCGDGSDERGCSDPACPPREFRCGGGGTCIPERWVCDRQFDCEDRSDEAAELCGRAGQGTTATPAACAPTAQFTCRSGECIHLGWRCDGDRDCKDKSDEADCSPGPCRENEFQCGDGTCVLAIKRCNQERDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECQDPDACSQICVNYKGYFKCECHPGYEMDTLTKNCKAVAGKSPSLIFTNRHEVRRIDLVKRDYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAHMDKASIPDEQVVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATTDGRRRCTLFSRELSEPRAIAVDPLRGFMYWSDWGFQAKIEKAGLNGADRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFNGGNRKMLIFSTDFLSHPFGVAVFEDKVFWTDLENEAIFSANRLNGLEIAILAENLNNPHDIVIFHELKQPKAADACDLSAQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASAMTRTVPATTRAPGTTIHDPTYQNHSTETPSQTAAAPHSVNVPRAPSTSPSTPSPATSNHSQHYGNEGSQMGSTVTAAVIGVIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEEEDELHIGRTAQIGHVYPARVALSLEDDGLP", "length": 896, "header": "tr|B1AXJ5-1|B1AXJ5_MOUSE Computationally mapped isoform of Low density lipoprotein receptor-related protein 8, apolipoprotein e receptor OS=Mus musculus OX=10090 GN=Lrp8 PE=1 SV=1 CANONICAL=Q924X6-1" }, "locus": { "chromosome": "4", "start_pos": 107729505, "end_pos": 107659610, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000106733.10", "url": "https://www.ensembl.org/id/ENSMUST00000106733.10" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000102344.3", "url": "https://www.ensembl.org/id/ENSMUSP00000102344.3" } ] } }, { "isoform_ac": "B1AXJ6-1", "url": "", "sequence": { "sequence": "MGRPELGALRPLALLLLLLLQLQHLSAADPLPGGQGPVKECEEDQFRCRNERCIPLVWRCDEDNDCSDNSDEDDCPKRTCADSDFTCDNGHCIPERWKCDGEEECPDGSDESKATCSSEECPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCPTSPGPCRENEFQCGDGTCVLAIKRCNQERDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECQDPDACSQICVNYKGYFKCECHPGYEMDTLTKNCKAVAGKSPSLIFTNRHEVRRIDLVKRDYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAHMDKASIPDEQVVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATTDGRRRCTLFSRELSEPRAIAVDPLRGFMYWSDWGFQAKIEKAGLNGADRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFNGGNRKMLIFSTDFLSHPFGVAVFEDKVFWTDLENEAIFSANRLNGLEIAILAENLNNPHDIVIFHELKQPKAADACDLSAQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRDGNEGSQMGSTVTAAVIGVIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEEEDELHIGRTAQIGHVYPARVALSLEDDGLP", "length": 694, "header": "tr|B1AXJ6-1|B1AXJ6_MOUSE Computationally mapped isoform of Low density lipoprotein receptor-related protein 8, apolipoprotein e receptor OS=Mus musculus OX=10090 GN=Lrp8 PE=1 SV=1 CANONICAL=Q924X6-1" }, "locus": { "chromosome": "4", "start_pos": 107729505, "end_pos": 107659610, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000126573.8", "url": "https://www.ensembl.org/id/ENSMUST00000126573.8" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000118020.2", "url": "https://www.ensembl.org/id/ENSMUSP00000118020.2" } ] } }, { "isoform_ac": "F6YZZ8-1", "url": "", "sequence": { "sequence": "MGRPELGALRPLALLLLLLLQLQHLSAADPLPGGQGPVKECEEDQFRCRNERCIPLVWRCDEDNDCSDNSDEDDCPKRTCADSDFTCDNGHCIPERWKCDGEEECPDGSDESKATCSSEECPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCPTSAPGPCRENEFQCGDGTCVLAIKRCNQERDCPDGSDEAGCLQESTCEGPRRFQCKSGECVDGGKVCDDQRDCRDWSDEPQKVCGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECQDPDACSQICVNYKGYFKCECHPGYEMDTLTKNCKAVAGKSPSLIFTNRHEVRRIDLVKRDYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAHMDKASIPDEQVVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATTDGRRRCTLFSRELSEPRAIAVDPLRGFMYWSDWGFQAKIEKAGLNGADRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFNGGNRKMLIFSTDFLSHPFGVAVFEDKVFWTDLENEAIFSANRLNGLEIAILAENLNNPHDIVIFHELKQPKAADACDLSAQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASAMTRTVPATTRAPGTTIHDPTYQNHSTETPSQTAAAPHSVNVPRAPSTSPSTPSPATSNHSQHYGNEGSQMGSTVTAAVIGVIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEEEDELHIGRTAQIGHVYPAAISNYDRPLWAEPCLGETRDLEDPAPALKELFVLPGEPRSQLHQLPKNPLSELPVVKCKRVALSLEDDGLP", "length": 870, "header": "tr|F6YZZ8-1|F6YZZ8_MOUSE Computationally mapped isoform of Low density lipoprotein receptor-related protein 8, apolipoprotein e receptor OS=Mus musculus OX=10090 GN=Lrp8 PE=1 SV=2 CANONICAL=Q924X6-1" }, "locus": { "chromosome": "4", "start_pos": 107729505, "end_pos": 107659610, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000106731.4", "url": "https://www.ensembl.org/id/ENSMUST00000106731.4" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000102342.4", "url": "https://www.ensembl.org/id/ENSMUSP00000102342.4" } ] } }, { "isoform_ac": "Q924X6-1", "url": "", "sequence": { "sequence": "MGRPELGALRPLALLLLLLLQLQHLSAADPLPGGQGPVKECEEDQFRCRNERCIPLVWRCDEDNDCSDNSDEDDCPKRTCADSDFTCDNGHCIPERWKCDGEEECPDGSDESKATCSSEECPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCPTLCAPHEFQCSNRSCLASVFVCDGDDDCGDGSDERGCSDPACPPREFRCGGGGTCIPERWVCDRQFDCEDRSDEAAELCGRAGQGTTATPAACAPTAQFTCRSGECIHLGWRCDGDRDCKDKSDEADCSPGPCRENEFQCGDGTCVLAIKRCNQERDCPDGSDEAGCLQESTCEGPRRFQCKSGECVDGGKVCDDQRDCRDWSDEPQKVCGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECQDPDACSQICVNYKGYFKCECHPGYEMDTLTKNCKAVAGKSPSLIFTNRHEVRRIDLVKRDYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAHMDKASIPDEQVVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATTDGRRRCTLFSRELSEPRAIAVDPLRGFMYWSDWGFQAKIEKAGLNGADRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFNGGNRKMLIFSTDFLSHPFGVAVFEDKVFWTDLENEAIFSANRLNGLEIAILAENLNNPHDIVIFHELKQPKAADACDLSAQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASAMTRTVPATTRAPGTTIHDPTYQNHSTETPSQTAAAPHSVNVPRAPSTSPSTPSPATSNHSQHYGNEGSQMGSTVTAAVIGVIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEEEDELHIGRTAQIGHVYPAAISNYDRPLWAEPCLGETRDLEDPAPALKELFVLPGEPRSQLHQLPKNPLSELPVVKCKRVALSLEDDGLP", "length": 996, "header": "sp|Q924X6-1|LRP8_MOUSE Isoform 1 of Low-density lipoprotein receptor-related protein 8 OS=Mus musculus OX=10090 GN=Lrp8 PE=1 SV=2 CANONICAL=Q924X6-1" }, "locus": { "chromosome": "4", "start_pos": 107729505, "end_pos": 107659610, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENSMUST00000238569", "url": "https://www.ensembl.org/id/ENSMUST00000238569" }, { "database": "Ensembl Peptide", "id": "ENSMUSP00000158644", "url": "https://www.ensembl.org/id/ENSMUSP00000158644" } ] } }, { "isoform_ac": "Q924X6-2", "url": "", "sequence": { "sequence": "MGRPELGALRPLALLLLLLLQLQHLSAADPLPGGQGPVKECEEDQFRCRNERCIPLVWRCDEDNDCSDNSDEDDCPKRTCADSDFTCDNGHCIPERWKCDGEEECPDGSDESKATCSSEECPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCPTCSPGPCRENEFQCGDGTCVLAIKRCNQERDCPDGSDEAGCLQESTCEGPRRFQCKSGECVDGGKVCDDQRDCRDWSDEPQKVCGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECQDPDACSQICVNYKGYFKCECHPGYEMDTLTKNCKAVAGKSPSLIFTNRHEVRRIDLVKRDYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAHMDKASIPDEQVVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATTDGRRRCTLFSRELSEPRAIAVDPLRGFMYWSDWGFQAKIEKAGLNGADRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFNGGNRKMLIFSTDFLSHPFGVAVFEDKVFWTDLENEAIFSANRLNGLEIAILAENLNNPHDIVIFHELKQPKAADACDLSAQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASAMTRTVPATTRAPGTTIHDPTYQNHSTETPSQTAAAPHSVNVPRAPSTSPSTPSPATSNHSQHYGNEGSQMGSTVTAAVIGVIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEEEDELHIGRTAQIGHVYPAAISNYDRPLWAEPCLGETRDLEDPAPALKELFVLPGEPRSQLHQLPKNPLSELPVVKCKRVALSLEDDGLP", "length": 870, "header": "sp|Q924X6-2|LRP8_MOUSE Isoform 2 of Low-density lipoprotein receptor-related protein 8 OS=Mus musculus OX=10090 GN=Lrp8 PE=1 SV=2 CANONICAL=Q924X6-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 170, "start_aa": "Asn", "end_pos": 170, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn170", "evidence": [ { "id": "Q924X6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q924X6#ptm_processing" } ] }, { "glytoucan_ac": "G06110VR", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 551, "start_aa": "Asn", "end_pos": 551, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn551", "evidence": [ { "id": "2487", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2487" }, { "id": "30899004", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30899004" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 551, "start_aa": "Asn", "end_pos": 551, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn551", "evidence": [ { "id": "Q924X6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q924X6#ptm_processing" } ] }, { "glytoucan_ac": "G14260UH", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 805, "start_aa": "Asn", "end_pos": 805, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn805", "evidence": [ { "id": "2487", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/2487" }, { "id": "30899004", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30899004" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 805, "start_aa": "Asn", "end_pos": 805, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn805", "evidence": [ { "id": "Q924X6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q924X6#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 840, "start_aa": "Asn", "end_pos": 840, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn840", "evidence": [ { "id": "Q924X6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q924X6#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted", "glycoprotein_reported", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2.", "journal": "Cell", "date": "1999", "authors": "Gotthardt M., Richardson J.A., Shelton J., Herz J., Nimpf J., Stockinger W., Hammer R.E., Trommsdorff M., Hiesberger T.", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "reference": [ { "type": "PubMed", "id": "10380922", "url": "https://glygen.org/publication/PubMed/10380922" } ] }, { "title": "The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and -2.", "journal": "J. Biol. Chem.", "date": "2000", "authors": "Gotthardt M., Hermann M., Herz J., Schneider W.J., Nimpf J., Stockinger W., Brandes C., Fasching D.", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "reference": [ { "type": "PubMed", "id": "10827199", "url": "https://glygen.org/publication/PubMed/10827199" } ] }, { "title": "Alternative splicing in the ligand binding domain of mouse ApoE receptor-2 produces receptor variants binding reelin but not alpha2-macroglobulin.", "journal": "J. Biol. Chem.", "date": "2001", "authors": "Schneider W.J., Nimpf J., Stockinger W., Brandes C., Kahr L., Hiesberger T.", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "reference": [ { "type": "PubMed", "id": "11294845", "url": "https://glygen.org/publication/PubMed/11294845" } ] }, { "title": "The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor.", "journal": "EMBO J.", "date": "2002", "authors": "Schneider W.J., Nimpf J., Stockinger W., Fasching D., Kahr L., Recheis B., Sailler B., Strasser V.", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "reference": [ { "type": "PubMed", "id": "12169628", "url": "https://glygen.org/publication/PubMed/12169628" } ] }, { "title": "A secreted soluble form of ApoE receptor 2 acts as a dominant-negative receptor and inhibits Reelin signaling.", "journal": "EMBO J.", "date": "2002", "authors": "Koch S, Strasser V, Hauser C, Fasching D, Brandes C, Bajari TM, Schneider WJ, Nimpf J", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "reference": [ { "type": "PubMed", "id": "12426372", "url": "https://glygen.org/publication/PubMed/12426372" } ] }, { "title": "Receptor-type protein tyrosine phosphatase zeta as a component of the signaling receptor complex for midkine-dependent survival of embryonic neurons.", "journal": "Neurosci. Res.", "date": "2003", "authors": "Noda M., Yamamoto T., Maeda N., Muramatsu H., Sakaguchi N., Muramatsu T., Ichihara-Tanaka K., Sakuma S., Ikematsu S., Michikawa M.", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "reference": [ { "type": "PubMed", "id": "12573468", "url": "https://glygen.org/publication/PubMed/12573468" } ] }, { "title": "Essential role of the apolipoprotein E receptor-2 in sperm development.", "journal": "J. Biol. Chem.", "date": "2003", "authors": "Andersen O.M., Willnow T.E., Vorum H., Otto A., Yeung C.H., Erdmann B., Herz J., Andreassen T.K., Wellner M., Cooper T.G., Mueller E.C.", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "reference": [ { "type": "PubMed", "id": "12695510", "url": "https://glygen.org/publication/PubMed/12695510" } ] }, { "title": "Differential glycosylation regulates processing of lipoprotein receptors by gamma-secretase.", "journal": "J. Biol. Chem.", "date": "2003", "authors": "May P, Bock HH, Nimpf J, Herz J", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "reference": [ { "type": "PubMed", "id": "12871934", "url": "https://glygen.org/publication/PubMed/12871934" } ] }, { "title": "Differential binding of ligands to the apolipoprotein E receptor 2.", "journal": "Biochemistry", "date": "2003", "authors": "Andersen OM, Benhayon D, Curran T, Willnow TE", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "reference": [ { "type": "PubMed", "id": "12899622", "url": "https://glygen.org/publication/PubMed/12899622" } ] }, { "title": "Megalin mediates selenoprotein P uptake by kidney proximal tubule epithelial cells.", "journal": "J. Biol. Chem.", "date": "2008", "authors": "Olson G.E., Winfrey V.P., Burk R.F., Hill K.E.", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "reference": [ { "type": "PubMed", "id": "18174160", "url": "https://glygen.org/publication/PubMed/18174160" } ] }, { "title": "LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer.", "journal": "Cell", "date": "2018", "authors": "Tavazoie MF, Pollack I, Tanqueco R, Ostendorf BN, Reis BS, Gonsalves FC, Kurth I, Andreu-Agullo C, Derbyshire ML, Posada J, Takeda S, Tafreshian KN, Rowinsky E, Szarek M, Waltzman RJ, Mcmillan EA, Zhao C, Mita M, Mita A, Chmielowski B, Postow MA, Ribas A, Mucida D, Tavazoie SF", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "reference": [ { "type": "PubMed", "id": "29336888", "url": "https://glygen.org/publication/PubMed/29336888" } ] }, { "title": "Capturing site-specific heterogeneity with large-scale N-glycoproteome analysis.", "journal": "Nature communications", "date": "2019", "authors": "Riley NM, Hebert AS, Westphall MS, Coon JJ", "evidence": [ { "database": "GlyConnect", "id": "2487", "url": "https://glyconnect.expasy.org/browser/proteins/2487" } ], "reference": [ { "type": "PubMed", "id": "30899004", "url": "https://glygen.org/publication/PubMed/30899004" } ] }, { "title": "VLDLR and ApoER2 are receptors for multiple alphaviruses.", "journal": "Nature", "date": "2022", "authors": "Clark LE, Clark SA, Lin C, Liu J, Coscia A, Nabel KG, Yang P, Neel DV, Lee H, Brusic V, Stryapunina I, Plante KS, Ahmed AA, Catteruccia F, Young-Pearse TL, Chiu IM, Llopis PM, Weaver SC, Abraham J", "evidence": [ { "database": "RefSeq", "id": "NP_001074395", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074395" } ], "reference": [ { "type": "PubMed", "id": "34929721", "url": "https://glygen.org/publication/PubMed/34929721" } ] }, { "title": "Single molecule, long-read Apoer2 sequencing identifies conserved and species-specific splicing patterns.", "journal": "Genomics", "date": "2022", "authors": "Gallo CM, Labadorf AT, Ho A, Beffert U", "evidence": [ { "database": "RefSeq", "id": "NP_001074395", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074395" } ], "reference": [ { "type": "PubMed", "id": "35192893", "url": "https://glygen.org/publication/PubMed/35192893" } ] }, { "title": "Different sensitivity to diet-induced hyperinsulinemia and hyperglycemia between mice with global or bone marrow-specific apoE receptor-2 deficiency.", "journal": "American journal of physiology. Regulatory, integrative and comparative physiology", "date": "2023-05-22", "authors": "Wolfkiel Patrick R, Haller April M, Kirby Jillian, Jaeschke Anja, Hui David Y", "evidence": [ { "database": "RefSeq", "id": "NP_001074395", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074395" } ], "reference": [ { "type": "PubMed", "id": "37212552", "url": "https://glygen.org/publication/PubMed/37212552" } ] }, { "title": "Regulation of the hippocampal translatome by Apoer2-ICD release.", "journal": "Molecular neurodegeneration", "date": "2023-09-19", "authors": "Wasser Catherine R, Werthmann Gordon C, Hall Eric M, Kuhbandner Kristina, Wong Connie H, Durakoglugil Murat S, Herz Joachim", "evidence": [ { "database": "RefSeq", "id": "NP_001074395", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074395" } ], "reference": [ { "type": "PubMed", "id": "37726747", "url": "https://glygen.org/publication/PubMed/37726747" } ] }, { "title": "Evolution of the apolipoprotein E receptor 2 gene by exon loss.", "journal": "J. Biochem.", "date": "1998", "authors": "Yamamoto T., Magoori K., Kim D.-H., Kim H.-J., Saeki S.", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "reference": [ { "type": "PubMed", "id": "9685741", "url": "https://glygen.org/publication/PubMed/9685741" } ] } ], "pathway": [ { "id": "mmu:16975", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:16975", "resource": "KEGG Pathway" }, { "id": "R-MMU-432142", "name": "Platelet sensitization by LDL", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-432142", "resource": "Reactome", "description": "Platelet sensitization by LDL" }, { "id": "R-MMU-975634", "name": "Retinoid metabolism and transport", "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-975634", "resource": "Reactome", "description": "Retinoid metabolism and transport" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5ZTA7-1", "protein_name": "LDL receptor related protein 8", 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"id": "45231474", "url": "http://www.informatics.jax.org/homology/45231474", "database": "MGI" } ], "common_name": "Human" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 20, "go_terms": [ { "name": "endocytosis", "id": "GO:0006897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006897", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "pmid": "" }, { "name": "positive regulation of protein tyrosine kinase activity", "id": "GO:0061098", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061098", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "pmid": "" }, { "name": "cellular response to cholesterol", "id": "GO:0071397", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071397", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "pmid": "" }, { "name": "chemical synaptic transmission", "id": "GO:0007268", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007268", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "pmid": "" }, { "name": "hippocampus development", "id": "GO:0021766", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021766", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "pmid": "" }, { "name": "positive regulation of protein kinase activity", "id": "GO:0045860", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045860", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "pmid": "" }, { "name": "cellular response to growth factor stimulus", "id": "GO:0071363", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071363", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "pmid": "" }, { "name": "positive regulation of peptidyl-tyrosine phosphorylation", "id": "GO:0050731", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050731", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "pmid": "" }, { "name": "regulation of apoptotic process", "id": "GO:0042981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042981", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "pmid": "" }, { "name": "dendrite morphogenesis", "id": "GO:0048813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048813", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "pmid": "" }, { "name": "modulation of chemical synaptic transmission", "id": "GO:0050804", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050804", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "pmid": "" }, { "name": "layer formation in cerebral cortex", "id": "GO:0021819", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021819", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "pmid": "" }, { "name": "response to xenobiotic stimulus", "id": "GO:0009410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009410", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "pmid": "" }, { "name": "positive regulation of dendritic spine morphogenesis", "id": "GO:0061003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061003", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "pmid": "" }, { "name": "positive regulation of CREB transcription factor activity", "id": "GO:0032793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032793", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "pmid": "" }, { "name": "reelin-mediated signaling pathway", "id": "GO:0038026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038026", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "pmid": "" }, { "name": "positive regulation of dendrite development", "id": "GO:1900006", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900006", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "pmid": "" }, { "name": "regulation of innate immune response", "id": "GO:0045088", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045088", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "pmid": "" }, { "name": "ammon gyrus development", "id": "GO:0021541", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021541", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "pmid": "" }, { "name": "ventral spinal cord development", "id": "GO:0021517", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021517", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 11, "go_terms": [ { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "pmid": "" }, { "name": "axon", "id": "GO:0030424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "pmid": "" }, { "name": "dendrite", "id": "GO:0030425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "pmid": "" }, { "name": "neuronal cell body", "id": "GO:0043025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "pmid": "" }, { "name": "receptor complex", "id": "GO:0043235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043235", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "pmid": "" }, { "name": "caveola", "id": "GO:0005901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005901", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "pmid": "" }, { "name": "microtubule associated complex", "id": "GO:0005875", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005875", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 9, "go_terms": [ { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "pmid": "" }, { "name": "apolipoprotein binding", "id": "GO:0034185", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034185", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "pmid": "" }, { "name": "calcium-dependent protein binding", "id": "GO:0048306", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048306", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "pmid": "" }, { "name": "amyloid-beta binding", "id": "GO:0001540", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001540", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "pmid": "" }, { "name": "kinesin binding", "id": "GO:0019894", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019894", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "pmid": "" }, { "name": "high-density lipoprotein particle binding", "id": "GO:0008035", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008035", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "pmid": "" }, { "name": "very-low-density lipoprotein particle receptor activity", "id": "GO:0030229", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030229", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "pmid": "" }, { "name": "low-density lipoprotein particle receptor activity", "id": "GO:0005041", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005041", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "pmid": "" }, { "name": "reelin receptor activity", "id": "GO:0038025", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038025", "evidence": [ { "database": "UniProtKB", "id": "Q924X6", "url": "https://www.uniprot.org/uniprot/Q924X6" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 170, "end_pos": 172, "annotation": "n_glycosylation_sequon" }, { "start_pos": 551, "end_pos": 553, "annotation": "n_glycosylation_sequon" }, { "start_pos": 805, "end_pos": 807, "annotation": "n_glycosylation_sequon" }, { "start_pos": 840, "end_pos": 842, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "O-glycosylated. 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